locus-tag	class	description
G4Z02_00010	COG1309	transcriptional regulator
G4Z02_00035	COG0280	phosphate acetyltransferase
G4Z02_00040	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
G4Z02_00055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4Z02_00060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G4Z02_00065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4Z02_00075	COG0436	Aminotransferase
G4Z02_00090	COG1509	lysine 2,3-aminomutase activity
G4Z02_00100	COG2364	Membrane
G4Z02_00110	COG0737	Belongs to the 5'-nucleotidase family
G4Z02_00115	COG2356	endonuclease I
G4Z02_00125	COG0572	uridine kinase
G4Z02_00150	COG0737	Belongs to the 5'-nucleotidase family
G4Z02_00160	COG0366	Alpha amylase catalytic
G4Z02_00165	COG0395	ABC-type sugar transport system, permease component
G4Z02_00185	COG0395	ABC-type sugar transport system, permease component
G4Z02_00190	COG1175	transmembrane transport
G4Z02_00210	COG1523	belongs to the glycosyl hydrolase 13 family
G4Z02_00225	COG2119	membrane
G4Z02_00230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G4Z02_00245	COG2356	endonuclease I
G4Z02_00265	COG2608	mercury ion transmembrane transporter activity
G4Z02_00280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4Z02_00295	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4Z02_00305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G4Z02_00330	COG2217	Heavy metal translocating P-type atpase
G4Z02_00370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Z02_00440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G4Z02_00445	COG0557	exoribonuclease II activity
G4Z02_00470	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
G4Z02_00485	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G4Z02_00490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4Z02_00490	COG0574	Belongs to the PEP-utilizing enzyme family
G4Z02_00495	COG2878	Part of a membrane complex involved in electron transport
G4Z02_00505	COG4657	Part of a membrane complex involved in electron transport
G4Z02_00525	COG4656	Part of a membrane complex involved in electron transport
G4Z02_00530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4Z02_00535	COG0450	alkyl hydroperoxide reductase
G4Z02_00540	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
G4Z02_00545	COG2878	Part of a membrane complex involved in electron transport
G4Z02_00550	COG4657	Part of a membrane complex involved in electron transport
G4Z02_00555	COG4660	Part of a membrane complex involved in electron transport
G4Z02_00560	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
G4Z02_00575	COG1271	oxidase subunit
G4Z02_00590	COG0058	SHG alpha-glucan phosphorylase activity
G4Z02_00595	COG0297	glycogen (starch) synthase activity
G4Z02_00600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G4Z02_00610	COG2137	regulation of response to DNA damage stimulus
G4Z02_00615	COG0793	Belongs to the peptidase S41A family
G4Z02_00615	COG3409	Peptidoglycan-binding domain 1 protein
G4Z02_00620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4Z02_00625	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G4Z02_00630	COG0653	protein targeting
G4Z02_00655	COG3426	butyrate kinase activity
G4Z02_00695	COG0495	leucyl-tRNA aminoacylation
G4Z02_00705	COG1242	4 iron, 4 sulfur cluster binding
G4Z02_00710	COG0667	Aldo Keto reductase
G4Z02_00715	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
G4Z02_00720	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
G4Z02_00725	COG3051	citrate lyase alpha subunit
G4Z02_00735	COG3052	prosthetic group binding
G4Z02_00755	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G4Z02_00775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G4Z02_00780	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G4Z02_00785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G4Z02_00795	COG0561	phosphatase activity
G4Z02_00800	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G4Z02_00805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G4Z02_00810	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G4Z02_00825	COG0604	alcohol dehydrogenase
G4Z02_00830	COG3246	L-lysine catabolic process to acetate
G4Z02_00835	COG1607	acyl-coa hydrolase
G4Z02_00845	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G4Z02_00850	COG2030	dehydratase
G4Z02_00870	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
G4Z02_00875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G4Z02_00880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
G4Z02_00885	COG1609	Transcriptional regulator
G4Z02_00915	COG0534	Mate efflux family protein
G4Z02_00925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G4Z02_00930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G4Z02_00940	COG2740	Nucleic-acid-binding protein implicated in transcription termination
G4Z02_00945	COG0195	Participates in both transcription termination and antitermination
G4Z02_00950	COG0779	Required for maturation of 30S ribosomal subunits
G4Z02_00955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4Z02_00965	COG0301	tRNA thio-modification
G4Z02_00970	COG1956	GAF domain-containing protein
G4Z02_00985	COG0083	homoserine kinase activity
G4Z02_01015	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G4Z02_01035	COG2361	Protein of unknown function DUF86
G4Z02_01050	COG2832	Protein of unknown function (DUF454)
G4Z02_01065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4Z02_01085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4Z02_01090	COG5646	InterPro IPR014922
G4Z02_01095	COG1970	mechanosensitive ion channel activity
G4Z02_01100	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G4Z02_01105	COG0590	tRNA wobble adenosine to inosine editing
G4Z02_01110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4Z02_01115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Z02_01120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4Z02_01125	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G4Z02_01130	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G4Z02_01145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4Z02_01150	COG0167	dihydroorotate dehydrogenase activity
G4Z02_01155	COG0402	S-adenosylhomocysteine deaminase activity
G4Z02_01180	COG2080	2 iron, 2 sulfur cluster binding
G4Z02_01180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4Z02_01210	COG0149	triose-phosphate isomerase activity
G4Z02_01215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4Z02_01220	COG0126	phosphoglycerate kinase activity
G4Z02_01230	COG3842	ATPase activity
G4Z02_01235	COG2508	Transcriptional regulator
G4Z02_01245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G4Z02_01255	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Z02_01260	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Z02_01275	COG3833	ABC-type maltose transport systems, permease component
G4Z02_01295	COG0395	ABC-type sugar transport system, permease component
G4Z02_01300	COG4209	transmembrane transport
G4Z02_01345	COG1609	Transcriptional regulator
G4Z02_01350	COG0719	Fe-S assembly protein
G4Z02_01355	COG0822	iron-sulfur transferase activity
G4Z02_01360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4Z02_01365	COG0719	Fe-S assembly protein
G4Z02_01370	COG0396	ATPase activity
G4Z02_01400	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G4Z02_01410	COG3481	metal-dependent phosphohydrolase, HD sub domain
G4Z02_01415	COG1523	belongs to the glycosyl hydrolase 13 family
G4Z02_01420	COG0617	tRNA 3'-terminal CCA addition
G4Z02_01425	COG1739	Uncharacterized protein family UPF0029
G4Z02_01450	COG4657	Part of a membrane complex involved in electron transport
G4Z02_01460	COG4659	FMN binding
G4Z02_01465	COG4658	electron transport chain
G4Z02_01520	COG1846	Transcriptional regulator
G4Z02_01525	COG1307	EDD domain protein, DegV family
G4Z02_01530	COG0493	'glutamate synthase
G4Z02_01570	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G4Z02_01615	COG1136	(ABC) transporter
G4Z02_01615	COG0577	efflux transmembrane transporter activity
G4Z02_01620	COG4591	ABC-type transport system involved in lipoprotein release permease component
G4Z02_01620	COG1136	(ABC) transporter
G4Z02_01650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4Z02_01675	COG0671	phosphoesterase, PA-phosphatase related
G4Z02_01680	COG0457	Tetratricopeptide repeat
G4Z02_01680	COG0705	Rhomboid family
G4Z02_01690	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G4Z02_01700	COG0653	protein targeting
G4Z02_01705	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G4Z02_01710	COG1482	cell wall glycoprotein biosynthetic process
G4Z02_01715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G4Z02_01720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G4Z02_01735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4Z02_01740	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
G4Z02_01750	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G4Z02_01770	COG2089	acid synthase
G4Z02_01780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G4Z02_01785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G4Z02_01790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4Z02_01800	COG1216	Glycosyl transferase, family 2
G4Z02_01835	COG0489	protein tyrosine kinase activity
G4Z02_01855	COG0071	Belongs to the small heat shock protein (HSP20) family
G4Z02_01910	COG2096	Adenosyltransferase
G4Z02_01935	COG1131	(ABC) transporter
G4Z02_01955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4Z02_01970	COG1077	Cell shape determining protein MreB Mrl
G4Z02_01975	COG1077	Cell shape determining protein MreB Mrl
G4Z02_01980	COG1077	Cell shape determining protein MreB Mrl
G4Z02_01990	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
G4Z02_02005	COG0613	PHP domain protein
G4Z02_02010	COG0154	amidase activity
G4Z02_02020	COG4399	Belongs to the UPF0754 family
G4Z02_02025	COG2203	Gaf domain
G4Z02_02025	COG2199	diguanylate cyclase activity
G4Z02_02040	COG2816	NAD+ diphosphatase activity
G4Z02_02050	COG0494	nUDIX hydrolase
G4Z02_02055	COG1811	Na channel or pump
G4Z02_02070	COG0205	6-phosphofructokinase activity
G4Z02_02075	COG2814	Major facilitator Superfamily
G4Z02_02090	COG0475	glutathione-regulated potassium exporter activity
G4Z02_02090	COG0589	response to stress
G4Z02_02110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G4Z02_02120	COG0436	Aminotransferase
G4Z02_02125	COG4221	oxidoreductase activity
G4Z02_02145	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G4Z02_02150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G4Z02_02155	COG0116	Belongs to the methyltransferase superfamily
G4Z02_02180	COG1194	a g-specific adenine glycosylase
G4Z02_02185	COG1620	l-lactate permease
G4Z02_02215	COG1126	abc transporter atp-binding protein
G4Z02_02220	COG0765	amino acid transport
G4Z02_02225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4Z02_02230	COG0656	L-ascorbic acid biosynthetic process
G4Z02_02240	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G4Z02_02250	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G4Z02_02255	COG3639	organic phosphonate transmembrane transporter activity
G4Z02_02260	COG3639	organic phosphonate transmembrane transporter activity
G4Z02_02270	COG2514	catechol 2,3-dioxygenase activity
G4Z02_02275	COG1733	regulation of RNA biosynthetic process
G4Z02_02310	COG2309	aminopeptidase activity
G4Z02_02340	COG0640	Transcriptional regulator
G4Z02_02355	COG0004	ammonium transporteR
G4Z02_02380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G4Z02_02385	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G4Z02_02395	COG0366	Alpha amylase catalytic
G4Z02_02400	COG2190	(PTS) system
G4Z02_02400	COG2211	Major facilitator Superfamily
G4Z02_02405	COG1968	undecaprenyl-diphosphatase activity
G4Z02_02410	COG0708	Exodeoxyribonuclease III
G4Z02_02420	COG0493	'glutamate synthase
G4Z02_02435	COG0577	efflux transmembrane transporter activity
G4Z02_02435	COG1136	(ABC) transporter
G4Z02_02445	COG1254	Belongs to the acylphosphatase family
G4Z02_02450	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G4Z02_02460	COG1288	antiporter activity
G4Z02_02470	COG2212	antiporter activity
G4Z02_02485	COG2111	Na H antiporter
G4Z02_02490	COG1006	Multisubunit Na H antiporter MnhC subunit
G4Z02_02495	COG0651	ATP synthesis coupled electron transport
G4Z02_02510	COG0432	Pfam Uncharacterised protein family UPF0047
G4Z02_02520	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Z02_02555	COG1476	TRANSCRIPTIONal
G4Z02_02585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G4Z02_02610	COG1253	flavin adenine dinucleotide binding
G4Z02_02630	COG2200	EAL domain
G4Z02_02655	COG0534	Mate efflux family protein
G4Z02_02660	COG0321	lipoyl(octanoyl) transferase activity
G4Z02_02690	COG2814	Major facilitator Superfamily
G4Z02_02715	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G4Z02_02720	COG0798	PFAM Bile acid sodium symporter
G4Z02_02730	COG3590	peptidase
G4Z02_02735	COG0306	phosphate transporter
G4Z02_02750	COG5001	Diguanylate cyclase
G4Z02_02755	COG2361	Protein of unknown function DUF86
G4Z02_02780	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G4Z02_02790	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G4Z02_02815	COG4177	L-phenylalanine transmembrane transporter activity
G4Z02_02830	COG0367	asparagine synthase
G4Z02_02835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Z02_02840	COG4974	Belongs to the 'phage' integrase family
G4Z02_02850	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
G4Z02_02860	COG0366	Alpha amylase catalytic
G4Z02_02865	COG1609	Transcriptional regulator
G4Z02_02875	COG1309	transcriptional regulator
G4Z02_02885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4Z02_02895	COG0432	Pfam Uncharacterised protein family UPF0047
G4Z02_02900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4Z02_02920	COG0501	Belongs to the peptidase M48B family
G4Z02_02955	COG0556	nucleotide-excision repair
G4Z02_02960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4Z02_02970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4Z02_02980	COG1695	Transcriptional regulator
G4Z02_02990	COG0205	6-phosphofructokinase activity
G4Z02_02995	COG0587	DNA-directed DNA polymerase activity
G4Z02_03005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G4Z02_03015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G4Z02_03020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G4Z02_03030	COG0475	glutathione-regulated potassium exporter activity
G4Z02_03035	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G4Z02_03055	COG1368	sulfuric ester hydrolase activity
G4Z02_03075	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G4Z02_03085	COG0133	tryptophan synthase activity
G4Z02_03090	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G4Z02_03095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G4Z02_03100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G4Z02_03105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G4Z02_03110	COG0131	Imidazoleglycerol-phosphate dehydratase
G4Z02_03115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G4Z02_03120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G4Z02_03125	COG0107	imidazoleglycerol-phosphate synthase activity
G4Z02_03130	COG0140	phosphoribosyl-ATP diphosphatase activity
G4Z02_03130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G4Z02_03140	COG1307	EDD domain protein, DegV family
G4Z02_03145	COG1307	EDD domain protein, DegV family
G4Z02_03150	COG1272	protein, Hemolysin III
G4Z02_03185	COG1609	Transcriptional regulator
G4Z02_03200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4Z02_03220	COG1228	amidohydrolase
G4Z02_03230	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G4Z02_03235	COG2986	histidine ammonia-lyase
G4Z02_03240	COG0824	Thioesterase
G4Z02_03260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G4Z02_03260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G4Z02_03275	COG1595	DNA-templated transcription, initiation
G4Z02_03280	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G4Z02_03290	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G4Z02_03330	COG1744	ABC transporter substrate-binding protein PnrA-like
G4Z02_03345	COG2130	NADP-dependent
G4Z02_03400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G4Z02_03410	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G4Z02_03450	COG2217	Heavy metal translocating P-type atpase
G4Z02_03455	COG0640	Transcriptional regulator
G4Z02_03465	COG0667	Aldo Keto reductase
G4Z02_03470	COG1803	Methylglyoxal synthase
G4Z02_03495	COG0393	Putative heavy-metal-binding
G4Z02_03530	COG1280	lysine exporter protein (LysE YggA)
G4Z02_03560	COG3885	ferrous iron binding
G4Z02_03560	COG2078	PFAM AMMECR1 domain protein
G4Z02_03570	COG2211	Major facilitator Superfamily
G4Z02_03600	COG2183	response to ionizing radiation
G4Z02_03610	COG0736	holo-[acyl-carrier-protein] synthase activity
G4Z02_03615	COG1481	regulation of sporulation
G4Z02_03620	COG0492	ferredoxin-NADP+ reductase activity
G4Z02_03625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G4Z02_03630	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G4Z02_03640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4Z02_03645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G4Z02_03650	COG0210	DNA helicase
G4Z02_03655	COG3695	enzyme binding
G4Z02_03660	COG1278	Cold shock
G4Z02_03690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G4Z02_03715	COG0577	efflux transmembrane transporter activity
G4Z02_03715	COG1136	(ABC) transporter
G4Z02_03720	COG1136	(ABC) transporter
G4Z02_03720	COG0577	efflux transmembrane transporter activity
G4Z02_03725	COG0577	efflux transmembrane transporter activity
G4Z02_03725	COG1136	(ABC) transporter
G4Z02_03730	COG0577	efflux transmembrane transporter activity
G4Z02_03730	COG1136	(ABC) transporter
G4Z02_03735	COG1214	PFAM Peptidase M22, glycoprotease
G4Z02_03740	COG0802	atpase or kinase
G4Z02_03745	COG1597	lipid kinase activity
G4Z02_03755	COG0166	Belongs to the GPI family
G4Z02_03760	COG1098	S1 RNA binding domain
G4Z02_03765	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G4Z02_03775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G4Z02_03780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G4Z02_03795	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
G4Z02_03805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G4Z02_03810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4Z02_03815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G4Z02_03835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G4Z02_03850	COG2252	PERMEase
G4Z02_03860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G4Z02_03865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G4Z02_03875	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
G4Z02_03900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G4Z02_03905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G4Z02_03910	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G4Z02_03915	COG1605	Chorismate mutase
G4Z02_03915	COG0287	Prephenate dehydrogenase
G4Z02_03920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G4Z02_03925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G4Z02_03930	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G4Z02_03935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G4Z02_03940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G4Z02_03945	COG0193	aminoacyl-tRNA hydrolase activity
G4Z02_03955	COG0706	membrane insertase activity
G4Z02_03960	COG0594	ribonuclease P activity
G4Z02_03965	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G4Z02_03970	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G4Z02_03975	COG0592	DNA-directed DNA polymerase activity
G4Z02_03985	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G4Z02_03990	COG0187	DNA topoisomerase II activity
G4Z02_03995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4Z02_04000	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G4Z02_04020	COG0537	adenosine 5'-monophosphoramidase activity
G4Z02_04025	COG0546	phosphoglycolate phosphatase activity
G4Z02_04030	COG0280	phosphate acetyltransferase
G4Z02_04035	COG1597	lipid kinase activity
G4Z02_04050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G4Z02_04055	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G4Z02_04060	COG2088	sporulation resulting in formation of a cellular spore
G4Z02_04065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G4Z02_04075	COG0017	Asparaginyl-tRNA synthetase
G4Z02_04100	COG0037	tRNA processing
G4Z02_04115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G4Z02_04120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G4Z02_04125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G4Z02_04135	COG3842	ATPase activity
G4Z02_04140	COG1175	transmembrane transport
G4Z02_04145	COG3833	ABC-type maltose transport systems, permease component
G4Z02_04175	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G4Z02_04180	COG1283	sodium-dependent phosphate transmembrane transporter activity
G4Z02_04185	COG0745	RESPONSE REGULATOR receiver
G4Z02_04195	COG0573	inorganic phosphate transmembrane transporter activity
G4Z02_04200	COG0581	inorganic phosphate transmembrane transporter activity
G4Z02_04205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G4Z02_04210	COG0704	Plays a role in the regulation of phosphate uptake
G4Z02_04215	COG5002	protein histidine kinase activity
G4Z02_04225	COG3343	RNA polymerase activity
G4Z02_04230	COG0504	CTP synthase activity
G4Z02_04235	COG0312	modulator of DNA gyrase
G4Z02_04240	COG0312	modulator of DNA gyrase
G4Z02_04260	COG1045	serine acetyltransferase
G4Z02_04265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4Z02_04270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4Z02_04280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G4Z02_04285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4Z02_04290	COG0037	tRNA processing
G4Z02_04290	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
G4Z02_04305	COG2270	Major facilitator Superfamily
G4Z02_04325	COG0281	malic enzyme
G4Z02_04350	COG3655	Transcriptional regulator
G4Z02_04400	COG1435	thymidine kinase activity
G4Z02_04405	COG0590	tRNA wobble adenosine to inosine editing
G4Z02_04420	COG0561	phosphatase activity
G4Z02_04425	COG5002	protein histidine kinase activity
G4Z02_04430	COG0745	RESPONSE REGULATOR receiver
G4Z02_04435	COG0445	tRNA wobble uridine modification
G4Z02_04440	COG0357	Ribosomal RNA small subunit methyltransferase G
G4Z02_04455	COG1192	Involved in chromosome partitioning
G4Z02_04460	COG1475	DNA binding
G4Z02_04465	COG0668	transmembrane transport
G4Z02_04470	COG4481	Protein conserved in bacteria
G4Z02_04560	COG0516	GMP reductase activity
G4Z02_04560	COG0517	IMP dehydrogenase activity
G4Z02_04565	COG0138	bifunctional purine biosynthesis protein purh
G4Z02_04570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G4Z02_04570	COG0519	Catalyzes the synthesis of GMP from XMP
G4Z02_04575	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G4Z02_04580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4Z02_04610	COG0765	amino acid transport
G4Z02_04620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4Z02_04630	COG0641	radical SAM
G4Z02_04650	COG3459	Glycosyltransferase 36 associated
G4Z02_04655	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Z02_04665	COG0395	ABC-type sugar transport system, permease component
G4Z02_04680	COG0395	ABC-type sugar transport system, permease component
G4Z02_04720	COG0673	inositol 2-dehydrogenase activity
G4Z02_04725	COG0673	inositol 2-dehydrogenase activity
G4Z02_04740	COG2211	Major facilitator Superfamily
G4Z02_04745	COG3250	beta-galactosidase activity
G4Z02_04765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Z02_04770	COG0386	Belongs to the glutathione peroxidase family
G4Z02_04785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4Z02_04800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Z02_04805	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G4Z02_04815	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z02_04820	COG1904	glucuronate isomerase
G4Z02_04830	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
G4Z02_04830	COG2199	diguanylate cyclase activity
G4Z02_04935	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G4Z02_04940	COG4268	DNA restriction-modification system
G4Z02_04945	COG1401	restriction endodeoxyribonuclease activity
G4Z02_04980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4Z02_04990	COG3037	sugar-specific permease SgaT UlaA
G4Z02_05015	COG2226	methyltransferase
G4Z02_05020	COG3339	Conserved Protein
G4Z02_05040	COG0519	Catalyzes the synthesis of GMP from XMP
G4Z02_05055	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G4Z02_05070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G4Z02_05080	COG0513	Belongs to the DEAD box helicase family
G4Z02_05135	COG0584	glycerophosphoryl diester phosphodiesterase
G4Z02_05145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G4Z02_05170	COG3804	dihydrodipicolinate reductase
G4Z02_05175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4Z02_05185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4Z02_05195	COG5012	cobalamin binding
G4Z02_05205	COG3457	Alanine racemase
G4Z02_05210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G4Z02_05220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4Z02_05250	COG0107	imidazoleglycerol-phosphate synthase activity
G4Z02_05260	COG0051	transcription antitermination factor activity, RNA binding
G4Z02_05265	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G4Z02_05270	COG0088	Forms part of the polypeptide exit tunnel
G4Z02_05275	COG0089	rRNA binding
G4Z02_05280	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G4Z02_05285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G4Z02_05295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G4Z02_05305	COG0255	Belongs to the universal ribosomal protein uL29 family
G4Z02_05325	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G4Z02_05335	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G4Z02_05340	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G4Z02_05345	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G4Z02_05350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G4Z02_05355	COG1841	ribosomal large subunit assembly
G4Z02_05360	COG0200	Binds to the 23S rRNA
G4Z02_05365	COG0201	protein transport
G4Z02_05370	COG0563	adenylate kinase activity
G4Z02_05375	COG0024	Methionine aminopeptidase
G4Z02_05380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G4Z02_05385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G4Z02_05390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G4Z02_05395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G4Z02_05405	COG0203	ribosomal protein L17
G4Z02_05425	COG1131	(ABC) transporter
G4Z02_05440	COG1122	ATPase activity
G4Z02_05445	COG1122	ATPase activity
G4Z02_05455	COG0101	tRNA pseudouridine synthase activity
G4Z02_05475	COG0006	proline dipeptidase activity
G4Z02_05515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4Z02_05520	COG1121	(ABC) transporter
G4Z02_05530	COG0470	DNA polymerase III
G4Z02_05535	COG1774	PSP1 C-terminal conserved region
G4Z02_05540	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
G4Z02_05545	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G4Z02_05560	COG2226	methyltransferase
G4Z02_05575	COG2217	Heavy metal translocating P-type atpase
G4Z02_05590	COG0745	RESPONSE REGULATOR receiver
G4Z02_05615	COG2217	Heavy metal translocating P-type atpase
G4Z02_05620	COG2217	Heavy metal translocating P-type atpase
G4Z02_05630	COG0745	RESPONSE REGULATOR receiver
G4Z02_05635	COG2205	protein histidine kinase activity
G4Z02_05710	COG2003	Belongs to the UPF0758 family
G4Z02_05725	COG0813	purine-nucleoside phosphorylase activity
G4Z02_05735	COG0456	acetyltransferase
G4Z02_05740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G4Z02_05810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4Z02_05825	COG2814	Major facilitator Superfamily
G4Z02_05830	COG1695	Transcriptional regulator
G4Z02_05875	COG2199	diguanylate cyclase activity
G4Z02_05885	COG1131	(ABC) transporter
G4Z02_05915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G4Z02_05920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G4Z02_05935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Z02_05940	COG3437	response regulator, receiver
G4Z02_05940	COG0784	Response regulator, receiver
G4Z02_05945	COG5001	Diguanylate cyclase
G4Z02_05975	COG1940	carbohydrate kinase activity
G4Z02_05985	COG1187	pseudouridine synthase activity
G4Z02_05995	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z02_06000	COG1473	amidohydrolase
G4Z02_06005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4Z02_06010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4Z02_06010	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
G4Z02_06020	COG0215	cysteine-tRNA ligase activity
G4Z02_06025	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
G4Z02_06050	COG0784	Response regulator, receiver
G4Z02_06050	COG5002	protein histidine kinase activity
G4Z02_06050	COG2205	protein histidine kinase activity
G4Z02_06055	COG0745	RESPONSE REGULATOR receiver
G4Z02_06065	COG0745	RESPONSE REGULATOR receiver
G4Z02_06085	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
G4Z02_06095	COG4166	transmembrane transport
G4Z02_06100	COG0601	transmembrane transport
G4Z02_06105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Z02_06115	COG0444	Belongs to the ABC transporter superfamily
G4Z02_06120	COG4608	Belongs to the ABC transporter superfamily
G4Z02_06140	COG3681	Belongs to the UPF0597 family
G4Z02_06155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G4Z02_06170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G4Z02_06175	COG0081	regulation of translation
G4Z02_06180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G4Z02_06185	COG0222	ribosome binding
G4Z02_06190	COG2813	Specifically methylates the guanine in position
G4Z02_06195	COG0085	RNA polymerase activity
G4Z02_06200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G4Z02_06225	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G4Z02_06230	COG0049	tRNA binding
G4Z02_06240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G4Z02_06290	COG3706	GGDEF domain
G4Z02_06300	COG1840	ABC-type Fe3 transport system, periplasmic component
G4Z02_06310	COG3842	ATPase activity
G4Z02_06320	COG0084	hydrolase, TatD family'
G4Z02_06325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4Z02_06330	COG0012	GTP binding
G4Z02_06335	COG0384	phenazine biosynthesis protein PhzF
G4Z02_06340	COG1058	Belongs to the CinA family
G4Z02_06340	COG1546	Belongs to the CinA family
G4Z02_06355	COG0360	Binds together with S18 to 16S ribosomal RNA
G4Z02_06360	COG0629	single-stranded DNA binding
G4Z02_06365	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G4Z02_06370	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
G4Z02_06375	COG0305	Participates in initiation and elongation during chromosome replication
G4Z02_06380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G4Z02_06390	COG1027	Aspartate ammonia-lyase
G4Z02_06395	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G4Z02_06405	COG0534	Mate efflux family protein
G4Z02_06410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G4Z02_06420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4Z02_06425	COG0552	protein localization to endoplasmic reticulum
G4Z02_06430	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
G4Z02_06435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G4Z02_06445	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
G4Z02_06450	COG3239	Fatty acid desaturase
G4Z02_06455	COG0561	phosphatase activity
G4Z02_06465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4Z02_06470	COG1674	ftsk spoiiie
G4Z02_06475	COG0681	Belongs to the peptidase S26 family
G4Z02_06480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G4Z02_06485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G4Z02_06495	COG1132	(ABC) transporter
G4Z02_06500	COG0698	ribose 5-phosphate isomerase
G4Z02_06505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G4Z02_06520	COG0356	it plays a direct role in the translocation of protons across the membrane
G4Z02_06525	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4Z02_06535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4Z02_06540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G4Z02_06545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G4Z02_06550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G4Z02_06555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G4Z02_06565	COG1268	BioY protein
G4Z02_06575	COG0511	ligase activity, forming carbon-carbon bonds
G4Z02_06580	COG0439	Biotin carboxylase
G4Z02_06585	COG0825	malonyl-CoA metabolic process
G4Z02_06585	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G4Z02_06590	COG0825	malonyl-CoA metabolic process
G4Z02_06595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4Z02_06600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G4Z02_06605	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z02_06610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4Z02_06615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G4Z02_06630	COG0756	dUTP diphosphatase activity
G4Z02_06650	COG0052	Belongs to the universal ribosomal protein uS2 family
G4Z02_06655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G4Z02_06660	COG0528	UMP kinase activity
G4Z02_06675	COG4589	Belongs to the CDS family
G4Z02_06680	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G4Z02_06685	COG0750	zinc metalloprotease
G4Z02_06690	COG0442	prolyl-tRNA aminoacylation
G4Z02_06750	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
G4Z02_06760	COG4658	electron transport chain
G4Z02_06765	COG0251	oxidation-reduction process
G4Z02_06770	COG2033	superoxide reductase activity
G4Z02_06835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4Z02_06840	COG0765	amino acid transport
G4Z02_06850	COG0009	L-threonylcarbamoyladenylate synthase
G4Z02_06855	COG0428	transporter
G4Z02_06885	COG0534	Mate efflux family protein
G4Z02_06905	COG0170	dolichyl monophosphate biosynthetic process
G4Z02_06935	COG1979	alcohol dehydrogenase
G4Z02_06945	COG0598	Magnesium transport protein CorA
G4Z02_06955	COG0745	RESPONSE REGULATOR receiver
G4Z02_06975	COG0194	GDP metabolic process
G4Z02_06980	COG1228	amidohydrolase
G4Z02_06990	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4Z02_06990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G4Z02_07000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4Z02_07000	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4Z02_07010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4Z02_07015	COG1012	belongs to the aldehyde dehydrogenase family
G4Z02_07025	COG3290	protein histidine kinase activity
G4Z02_07030	COG4565	transcriptional regulatory protein
G4Z02_07035	COG1063	alcohol dehydrogenase
G4Z02_07040	COG0156	8-amino-7-oxononanoate synthase activity
G4Z02_07065	COG0546	phosphoglycolate phosphatase activity
G4Z02_07080	COG0798	PFAM Bile acid sodium symporter
G4Z02_07095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4Z02_07100	COG0242	peptide deformylase activity
G4Z02_07110	COG4476	Belongs to the UPF0223 family
G4Z02_07120	COG1187	pseudouridine synthase activity
G4Z02_07125	COG1104	cysteine desulfurase activity
G4Z02_07140	COG3679	Belongs to the UPF0342 family
G4Z02_07155	COG1837	Belongs to the UPF0109 family
G4Z02_07160	COG0456	acetyltransferase
G4Z02_07165	COG4555	ABC transporter
G4Z02_07170	COG1668	transmembrane transport
G4Z02_07175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G4Z02_07180	COG0336	Belongs to the RNA methyltransferase TrmD family
G4Z02_07190	COG0335	large ribosomal subunit rRNA binding
G4Z02_07195	COG1609	Transcriptional regulator
G4Z02_07205	COG0640	Transcriptional regulator
G4Z02_07210	COG2217	Heavy metal translocating P-type atpase
G4Z02_07220	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
G4Z02_07220	COG2199	diguanylate cyclase activity
G4Z02_07230	COG1363	Peptidase, m42
G4Z02_07240	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G4Z02_07245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4Z02_07250	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4Z02_07250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4Z02_07255	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G4Z02_07270	COG0237	dephospho-CoA kinase activity
G4Z02_07280	COG3611	Membrane attachment protein
G4Z02_07285	COG1484	DNA-dependent DNA replication
G4Z02_07290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G4Z02_07295	COG1293	RNA-binding protein homologous to eukaryotic snRNP
G4Z02_07300	COG0194	GDP metabolic process
G4Z02_07305	COG1758	RNA polymerase activity
G4Z02_07310	COG2176	DNA-directed DNA polymerase activity
G4Z02_07335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4Z02_07335	COG0072	phenylalanine-tRNA ligase activity
G4Z02_07350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4Z02_07355	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
G4Z02_07365	COG2135	peptidase activity
G4Z02_07410	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
G4Z02_07440	COG1162	GTPase activity
G4Z02_07455	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G4Z02_07460	COG2226	methyltransferase
G4Z02_07465	COG1461	Dihydroxyacetone kinase
G4Z02_07470	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G4Z02_07475	COG0416	fatty acid biosynthetic process
G4Z02_07480	COG0571	ribonuclease III activity
G4Z02_07485	COG3935	DnaD domain protein
G4Z02_07490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G4Z02_07500	COG0489	protein tyrosine kinase activity
G4Z02_07550	COG2239	Acts as a magnesium transporter
G4Z02_07555	COG2153	protein acetylation
G4Z02_07565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4Z02_07585	COG0180	Tryptophanyl-tRNA synthetase
G4Z02_07595	COG1393	Belongs to the ArsC family
G4Z02_07605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G4Z02_07610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G4Z02_07615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G4Z02_07625	COG4122	O-methyltransferase activity
G4Z02_07640	COG0572	uridine kinase
G4Z02_07645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4Z02_07650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G4Z02_07670	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G4Z02_07675	COG1713	HD superfamily hydrolase involved in NAD metabolism
G4Z02_07680	COG0799	negative regulation of ribosome biogenesis
G4Z02_07685	COG2226	methyltransferase
G4Z02_07695	COG1596	polysaccharide export
G4Z02_07695	COG1555	photosystem II stabilization
G4Z02_07700	COG0658	competence protein
G4Z02_07700	COG2333	competence protein COMEC
G4Z02_07705	COG1466	dna polymerase III delta subunit
G4Z02_07710	COG0268	Binds directly to 16S ribosomal RNA
G4Z02_07715	COG1671	Belongs to the UPF0178 family
G4Z02_07725	COG2996	Protein conserved in bacteria
G4Z02_07740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4Z02_07745	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G4Z02_07760	COG1418	mRNA catabolic process
G4Z02_07760	COG4372	Transposase
G4Z02_07765	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
G4Z02_07770	COG1692	metallophosphoesterase
G4Z02_07775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4Z02_07790	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G4Z02_07815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G4Z02_07820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G4Z02_07835	COG1902	pentaerythritol trinitrate reductase activity
G4Z02_07855	COG1131	(ABC) transporter
G4Z02_07865	COG0405	Gamma-glutamyltransferase
G4Z02_07875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G4Z02_07880	COG4536	flavin adenine dinucleotide binding
G4Z02_07885	COG1187	pseudouridine synthase activity
G4Z02_07890	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G4Z02_07895	COG0539	negative regulation of cytoplasmic translation
G4Z02_07905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G4Z02_07910	COG0776	regulation of translation
G4Z02_07930	COG0569	domain protein
G4Z02_07940	COG1592	Rubrerythrin
G4Z02_07960	COG0366	Alpha amylase catalytic
G4Z02_07970	COG3842	ATPase activity
G4Z02_07975	COG1176	ABC-type spermidine putrescine transport system, permease component I
G4Z02_07980	COG1177	transmembrane transport
G4Z02_07990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4Z02_07995	COG1570	exodeoxyribonuclease VII activity
G4Z02_08000	COG1722	exodeoxyribonuclease VII activity
G4Z02_08005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G4Z02_08010	COG0497	DNA recombination
G4Z02_08030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G4Z02_08035	COG0513	Belongs to the DEAD box helicase family
G4Z02_08055	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G4Z02_08060	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G4Z02_08090	COG1363	Peptidase, m42
G4Z02_08095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G4Z02_08100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G4Z02_08100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4Z02_08105	COG0482	sulfurtransferase activity
G4Z02_08110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4Z02_08130	COG1131	(ABC) transporter
G4Z02_08140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4Z02_08145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4Z02_08150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G4Z02_08155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G4Z02_08165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G4Z02_08185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4Z02_08190	COG1846	Transcriptional regulator
G4Z02_08195	COG1363	Peptidase, m42
G4Z02_08200	COG0742	ribosomal rna small subunit methyltransferase
G4Z02_08205	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G4Z02_08235	COG1368	sulfuric ester hydrolase activity
G4Z02_08275	COG3177	Filamentation induced by cAMP protein fic
G4Z02_08325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4Z02_08370	COG0544	peptidyl-prolyl cis-trans isomerase activity
G4Z02_08375	COG3037	sugar-specific permease SgaT UlaA
G4Z02_08380	COG0561	phosphatase activity
G4Z02_08385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4Z02_08420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4Z02_08430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G4Z02_08485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G4Z02_08495	COG1609	Transcriptional regulator
G4Z02_08505	COG2160	L-arabinose isomerase activity
G4Z02_08510	COG0235	Class ii aldolase
G4Z02_08525	COG4214	carbohydrate transport
G4Z02_08535	COG0285	dihydrofolate synthase activity
G4Z02_08540	COG2003	Belongs to the UPF0758 family
G4Z02_08550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G4Z02_08570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G4Z02_08575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G4Z02_08580	COG0632	four-way junction helicase activity
G4Z02_08625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G4Z02_08635	COG1342	Belongs to the UPF0251 family
G4Z02_08655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G4Z02_08660	COG1328	CTP reductase activity
G4Z02_08665	COG1744	ABC transporter substrate-binding protein PnrA-like
G4Z02_08670	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G4Z02_08680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G4Z02_08685	COG0297	glycogen (starch) synthase activity
G4Z02_08715	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G4Z02_08720	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G4Z02_08730	COG0629	single-stranded DNA binding
G4Z02_08745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G4Z02_08755	COG0612	Peptidase, M16
G4Z02_08765	COG0813	purine-nucleoside phosphorylase activity
G4Z02_08785	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G4Z02_08800	COG1799	cell septum assembly
G4Z02_08805	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G4Z02_08815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G4Z02_08820	COG0343	queuine tRNA-ribosyltransferase activity
G4Z02_08830	COG2207	Transcriptional regulator
G4Z02_08830	COG3708	Transcriptional regulator
G4Z02_08835	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G4Z02_08840	COG3033	Beta-eliminating lyase
G4Z02_08850	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G4Z02_08855	COG2255	four-way junction helicase activity
G4Z02_08875	COG4974	Belongs to the 'phage' integrase family
G4Z02_08880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4Z02_08885	COG0481	GTPase activity
G4Z02_08890	COG3022	response to hydroperoxide
G4Z02_08910	COG1185	polyribonucleotide nucleotidyltransferase activity
G4Z02_08920	COG0628	permease
G4Z02_08925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G4Z02_08930	COG0196	riboflavin kinase activity
G4Z02_08935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G4Z02_08940	COG3118	belongs to the thioredoxin family
G4Z02_08945	COG1193	negative regulation of DNA recombination
G4Z02_08965	COG1979	alcohol dehydrogenase
G4Z02_08980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4Z02_08990	COG0564	pseudouridine synthase activity
G4Z02_08995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G4Z02_09005	COG3480	Lon protease (S16) C-terminal proteolytic domain
G4Z02_09020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Z02_09030	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G4Z02_09040	COG0628	permease
G4Z02_09050	COG0124	histidyl-tRNA synthetase
G4Z02_09070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4Z02_09075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G4Z02_09080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G4Z02_09080	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
G4Z02_09085	COG0018	arginyl-trna synthetase
G4Z02_09100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4Z02_09105	COG0187	DNA topoisomerase II activity
G4Z02_09110	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G4Z02_09120	COG3763	UPF0154 protein
G4Z02_09130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G4Z02_09140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4Z02_09145	COG0358	DNA primase activity
G4Z02_09150	COG0423	glycine-tRNA ligase activity
G4Z02_09155	COG1381	Involved in DNA repair and RecF pathway recombination
G4Z02_09160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G4Z02_09165	COG0295	cytidine deaminase activity
G4Z02_09170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G4Z02_09175	COG1702	phosphate starvation-inducible protein PhoH
G4Z02_09180	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G4Z02_09190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4Z02_09195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G4Z02_09205	COG0443	Heat shock 70 kDa protein
G4Z02_09210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G4Z02_09215	COG1420	regulation of RNA biosynthetic process
G4Z02_09220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4Z02_09225	COG1940	carbohydrate kinase activity
G4Z02_09230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G4Z02_09235	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G4Z02_09255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G4Z02_09265	COG1459	type II secretion system
G4Z02_09295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4Z02_09300	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G4Z02_09305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G4Z02_09310	COG0509	glycine decarboxylation via glycine cleavage system
G4Z02_09315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G4Z02_09320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G4Z02_09325	COG0776	regulation of translation
G4Z02_09340	COG0789	Transcriptional regulator
G4Z02_09350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4Z02_09355	COG4496	protein, YerC YecD
G4Z02_09360	COG1595	DNA-templated transcription, initiation
G4Z02_09365	COG4447	cellulose binding
G4Z02_09370	COG0493	'glutamate synthase
G4Z02_09375	COG0649	NAD binding
G4Z02_09385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Z02_09390	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G4Z02_09400	COG0651	ATP synthesis coupled electron transport
G4Z02_09420	COG1320	monovalent cation:proton antiporter activity
G4Z02_09425	COG2212	antiporter activity
G4Z02_09440	COG1132	(ABC) transporter
G4Z02_09445	COG1132	(ABC) transporter
G4Z02_09450	COG0488	(ABC) transporter
G4Z02_09460	COG1132	(ABC) transporter
G4Z02_09465	COG1132	(ABC) transporter
G4Z02_09475	COG0052	Belongs to the universal ribosomal protein uS2 family
G4Z02_09490	COG0656	L-ascorbic acid biosynthetic process
G4Z02_09500	COG1132	(ABC) transporter
G4Z02_09505	COG1132	(ABC) transporter
G4Z02_09530	COG2267	carboxylic ester hydrolase activity
G4Z02_09535	COG0596	Alpha beta hydrolase
G4Z02_09540	COG0427	acetyl-CoA hydrolase
G4Z02_09555	COG0411	ABC transporter
G4Z02_09570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4Z02_09575	COG1028	Short-chain dehydrogenase reductase Sdr