locus-tag	class	description
RN84_00010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RN84_00015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RN84_00020	COG0049	tRNA binding
RN84_00025	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RN84_00045	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
RN84_00110	COG2827	Endonuclease containing a URI domain
RN84_00115	COG0470	DNA polymerase III
RN84_00125	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
RN84_00130	COG0215	cysteine-tRNA ligase activity
RN84_00135	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RN84_00140	COG1193	negative regulation of DNA recombination
RN84_00165	COG4948	Mandelate Racemase Muconate Lactonizing
RN84_00185	COG1245	4Fe-4S binding domain
RN84_00185	COG2878	Part of a membrane complex involved in electron transport
RN84_00190	COG4657	Part of a membrane complex involved in electron transport
RN84_00195	COG4660	Part of a membrane complex involved in electron transport
RN84_00200	COG4659	FMN binding
RN84_00205	COG4658	electron transport chain
RN84_00210	COG4656	Part of a membrane complex involved in electron transport
RN84_00215	COG0193	aminoacyl-tRNA hydrolase activity
RN84_00230	COG0101	tRNA pseudouridine synthase activity
RN84_00240	COG1683	Conserved Protein
RN84_00255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RN84_00260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RN84_00260	COG1519	Transferase
RN84_00265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RN84_00270	COG2264	protein methyltransferase activity
RN84_00275	COG1692	metallophosphoesterase
RN84_00280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RN84_00290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RN84_00295	COG2805	Type II/IV secretion system protein
RN84_00300	COG0606	chelatase, subunit chli
RN84_00305	COG1971	Probably functions as a manganese efflux pump
RN84_00310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RN84_00330	COG0052	Belongs to the universal ribosomal protein uS2 family
RN84_00335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RN84_00340	COG0528	UMP kinase activity
RN84_00345	COG0233	cytoplasmic translational termination
RN84_00355	COG0200	Binds to the 23S rRNA
RN84_00360	COG1841	ribosomal large subunit assembly
RN84_00365	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RN84_00370	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RN84_00375	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RN84_00380	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RN84_00385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RN84_00390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RN84_00400	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RN84_00405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RN84_00410	COG0255	Belongs to the universal ribosomal protein uL29 family
RN84_00415	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RN84_00420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RN84_00425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RN84_00430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RN84_00435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RN84_00440	COG0089	rRNA binding
RN84_00445	COG0088	Forms part of the polypeptide exit tunnel
RN84_00450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RN84_00455	COG0051	transcription antitermination factor activity, RNA binding
RN84_00465	COG4608	Belongs to the ABC transporter superfamily
RN84_00475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RN84_00480	COG0601	transmembrane transport
RN84_00485	COG0747	negative chemotaxis
RN84_00490	COG0534	Mate efflux family protein
RN84_00505	COG0501	Belongs to the peptidase M48B family
RN84_00510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RN84_00515	COG0360	Binds together with S18 to 16S ribosomal RNA
RN84_00520	COG0442	prolyl-tRNA aminoacylation
RN84_00525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RN84_00530	COG0217	transcriptional regulatory protein
RN84_00565	COG1088	dTDP-glucose 4,6-dehydratase activity
RN84_00645	COG2089	acid synthase
RN84_00655	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
RN84_00660	COG1028	Short-chain dehydrogenase reductase Sdr
RN84_00670	COG1086	Polysaccharide biosynthesis protein
RN84_00685	COG1216	Glycosyl transferase, family 2
RN84_00730	COG1968	undecaprenyl-diphosphatase activity
RN84_00735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RN84_00740	COG1752	Esterase of the alpha-beta hydrolase superfamily
RN84_00750	COG2017	converts alpha-aldose to the beta-anomer
RN84_00755	COG1185	polyribonucleotide nucleotidyltransferase activity
RN84_00760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RN84_00770	COG0275	rRNA processing
RN84_00780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RN84_00805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RN84_00810	COG0653	protein targeting
RN84_00820	COG0357	Ribosomal RNA small subunit methyltransferase G
RN84_00825	COG0445	tRNA wobble uridine modification
RN84_00830	COG0569	domain protein
RN84_00835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RN84_00840	COG0534	Mate efflux family protein
RN84_00850	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RN84_00860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RN84_00865	COG0512	Glutamine amidotransferase of anthranilate synthase
RN84_00875	COG1394	ATPase activity, coupled to movement of substances
RN84_00880	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
RN84_00890	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
RN84_00895	COG1527	subunit (C
RN84_00900	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
RN84_00905	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RN84_00910	COG1269	ATP hydrolysis coupled proton transport
RN84_00920	COG0352	thiamine-phosphate diphosphorylase activity
RN84_00930	COG2022	thiamine diphosphate biosynthetic process
RN84_00945	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RN84_00950	COG0352	thiamine-phosphate diphosphorylase activity
RN84_00970	COG3022	response to hydroperoxide
RN84_00980	COG0148	phosphopyruvate hydratase activity
RN84_00985	COG0469	pyruvate kinase activity
RN84_01050	COG1185	polyribonucleotide nucleotidyltransferase activity
RN84_01050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RN84_01050	COG0539	negative regulation of cytoplasmic translation
RN84_01060	COG4820	ethanolamine utilization protein (EutJ)
RN84_01075	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RN84_01075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RN84_01080	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RN84_01085	COG0534	Mate efflux family protein
RN84_01095	COG1051	belongs to the nudix hydrolase family
RN84_01105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RN84_01110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN84_01125	COG3842	ATPase activity
RN84_01130	COG1176	ABC-type spermidine putrescine transport system, permease component I
RN84_01135	COG1177	transmembrane transport
RN84_01145	COG0786	glutamate:sodium symporter activity
RN84_01150	COG1309	transcriptional regulator
RN84_01155	COG2195	Cleaves the N-terminal amino acid of tripeptides
RN84_01200	COG0803	Belongs to the bacterial solute-binding protein 9 family
RN84_01225	COG2831	hemolysin activation secretion protein
RN84_01230	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
RN84_01240	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RN84_01250	COG0731	radical SAM domain protein
RN84_01250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RN84_01290	COG0484	heat shock protein binding
RN84_01295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RN84_01300	COG0443	Heat shock 70 kDa protein
RN84_01305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RN84_01310	COG1420	regulation of RNA biosynthetic process
RN84_01320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RN84_01330	COG1619	proteins homologs of microcin C7 resistance protein MccF
RN84_01335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RN84_01355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RN84_01360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RN84_01370	COG2871	sodium ion transport
RN84_01375	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RN84_01400	COG0813	purine-nucleoside phosphorylase activity
RN84_01405	COG1984	allophanate hydrolase subunit 2
RN84_01420	COG3118	belongs to the thioredoxin family
RN84_01440	COG3192	ethanolamine utilization protein
RN84_01465	COG1454	alcohol dehydrogenase
RN84_01465	COG1012	belongs to the aldehyde dehydrogenase family
RN84_01470	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RN84_01480	COG4816	utilization protein
RN84_01485	COG4302	ethanolamine ammonia-lyase activity
RN84_01490	COG4303	Ethanolamine ammonia lyase large subunit
RN84_01515	COG4810	utilization protein
RN84_01520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RN84_01525	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RN84_01525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RN84_01530	COG0302	gtp cyclohydrolase
RN84_01535	COG0751	glycine-tRNA ligase activity
RN84_01540	COG0752	glycyl-tRNA synthetase alpha subunit
RN84_01545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RN84_01550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RN84_01555	COG2205	protein histidine kinase activity
RN84_01560	COG2183	response to ionizing radiation
RN84_01580	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
RN84_01590	COG0822	iron-sulfur transferase activity
RN84_01595	COG1104	cysteine desulfurase activity
RN84_01600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RN84_01615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RN84_01620	COG1114	Component of the transport system for branched-chain amino acids
RN84_01625	COG1393	Belongs to the ArsC family
RN84_01630	COG1053	succinate dehydrogenase
RN84_01640	COG0647	UMP catabolic process
RN84_01645	COG0708	Exodeoxyribonuclease III
RN84_01655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RN84_01660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RN84_01675	COG0772	Belongs to the SEDS family
RN84_01685	COG0017	Asparaginyl-tRNA synthetase
RN84_01690	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
RN84_01770	COG1288	antiporter activity
RN84_01775	COG2088	sporulation resulting in formation of a cellular spore
RN84_01780	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RN84_01785	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RN84_01790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RN84_01830	COG1827	regulation of RNA biosynthetic process
RN84_01835	COG0157	Belongs to the NadC ModD family
RN84_01845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RN84_01850	COG0445	tRNA wobble uridine modification
RN84_01855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RN84_01860	COG1847	R3H domain protein
RN84_01865	COG0706	membrane insertase activity
RN84_01870	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RN84_01875	COG0594	ribonuclease P activity
RN84_01895	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RN84_01905	COG0187	DNA topoisomerase II activity
RN84_01910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RN84_01920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RN84_01925	COG0072	phenylalanine-tRNA ligase activity
RN84_01925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RN84_01990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RN84_01995	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
RN84_02000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RN84_02005	COG1288	antiporter activity
RN84_02020	COG3181	Tripartite tricarboxylate transporter family receptor
RN84_02025	COG0488	(ABC) transporter
RN84_02030	COG0697	spore germination
RN84_02040	COG2832	Protein of unknown function (DUF454)
RN84_02060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RN84_02065	COG1459	type II secretion system
RN84_02105	COG1450	Type ii and iii secretion system protein
RN84_02125	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RN84_02135	COG4120	Belongs to the binding-protein-dependent transport system permease family
RN84_02140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RN84_02170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RN84_02195	COG1115	amino acid carrier protein
RN84_02200	COG1078	dGTPase activity
RN84_02205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RN84_02265	COG0166	Belongs to the GPI family
RN84_02270	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
RN84_02335	COG1263	PTS System
RN84_02335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RN84_02340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RN84_02350	COG0644	oxidoreductase
RN84_02365	COG0142	geranyltranstransferase activity
RN84_02375	COG1556	Lactate utilization protein
RN84_02380	COG0003	Pfam Anion-transporting ATPase
RN84_02385	COG0003	Pfam Anion-transporting ATPase
RN84_02390	COG0277	FAD linked oxidase domain protein
RN84_02395	COG1960	acyl-CoA dehydrogenase activity
RN84_02405	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RN84_02410	COG1380	Effector of murein hydrolase LrgA
RN84_02440	COG4608	Belongs to the ABC transporter superfamily
RN84_02445	COG0444	Belongs to the ABC transporter superfamily
RN84_02450	COG0747	negative chemotaxis
RN84_02455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RN84_02465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RN84_02470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RN84_02475	COG1595	DNA-templated transcription, initiation
RN84_02480	COG0495	leucyl-tRNA aminoacylation
RN84_02515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RN84_02515	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RN84_02530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RN84_02530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RN84_02535	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RN84_02540	COG0747	negative chemotaxis
RN84_02545	COG0601	transmembrane transport
RN84_02550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RN84_02555	COG0444	Belongs to the ABC transporter superfamily
RN84_02575	COG2814	Major facilitator Superfamily
RN84_02580	COG1792	Involved in formation and maintenance of cell shape
RN84_02595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RN84_02595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RN84_02595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN84_02600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RN84_02605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RN84_02610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RN84_02615	COG4492	Belongs to the UPF0735 family
RN84_02635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RN84_02640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RN84_02645	COG0343	queuine tRNA-ribosyltransferase activity
RN84_02650	COG2239	Acts as a magnesium transporter
RN84_02670	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
RN84_02675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RN84_02685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RN84_02685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RN84_02690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RN84_02700	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
RN84_02740	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
RN84_02745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RN84_02750	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RN84_02760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RN84_02765	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RN84_02770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RN84_02775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RN84_02780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RN84_02785	COG1181	Belongs to the D-alanine--D-alanine ligase family
RN84_02800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RN84_02805	COG2985	domain, Protein
RN84_02805	COG0569	domain protein
RN84_02815	COG4804	nuclease activity
RN84_02865	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RN84_02870	COG0519	Catalyzes the synthesis of GMP from XMP
RN84_02870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RN84_02875	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RN84_02875	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RN84_02875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN84_02880	COG1105	Belongs to the carbohydrate kinase PfkB family
RN84_02885	COG1349	DNA-binding transcription factor activity
RN84_02895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RN84_02915	COG4221	oxidoreductase activity
RN84_02925	COG0559	Belongs to the binding-protein-dependent transport system permease family
RN84_02935	COG0411	ABC transporter
RN84_02940	COG0410	ABC transporter
RN84_02945	COG0384	phenazine biosynthesis protein PhzF
RN84_02955	COG0006	proline dipeptidase activity
RN84_02970	COG1960	acyl-CoA dehydrogenase activity
RN84_02975	COG0426	domain, Protein
RN84_02975	COG1773	rubredoxin
RN84_02995	COG0626	cystathionine gamma-synthase activity
RN84_03000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RN84_03005	COG0235	Class ii aldolase
RN84_03010	COG0436	Aminotransferase
RN84_03015	COG1979	alcohol dehydrogenase
RN84_03030	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
RN84_03035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RN84_03045	COG2195	Cleaves the N-terminal amino acid of tripeptides
RN84_03055	COG2986	histidine ammonia-lyase
RN84_03070	COG2056	Na+-H+ antiporter family
RN84_03080	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RN84_03085	COG3629	intracellular signal transduction
RN84_03095	COG1115	amino acid carrier protein
RN84_03100	COG2066	Belongs to the glutaminase family
RN84_03110	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
RN84_03115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RN84_03120	COG0228	four-way junction DNA binding
RN84_03150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RN84_03170	COG1373	ATPase (AAA superfamily
RN84_03190	COG3052	prosthetic group binding
RN84_03215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RN84_03220	COG0564	pseudouridine synthase activity
RN84_03225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RN84_03230	COG0792	nuclease activity
RN84_03240	COG1040	competence protein
RN84_03250	COG0149	triose-phosphate isomerase activity
RN84_03260	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RN84_03265	COG4608	Belongs to the ABC transporter superfamily
RN84_03270	COG0444	Belongs to the ABC transporter superfamily
RN84_03275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RN84_03285	COG0747	negative chemotaxis
RN84_03305	COG0577	efflux transmembrane transporter activity
RN84_03310	COG0577	efflux transmembrane transporter activity
RN84_03310	COG1136	(ABC) transporter
RN84_03315	COG1136	(ABC) transporter
RN84_03335	COG1136	(ABC) transporter
RN84_03365	COG0084	hydrolase, TatD family'
RN84_03370	COG0736	holo-[acyl-carrier-protein] synthase activity
RN84_03395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RN84_03425	COG4974	Belongs to the 'phage' integrase family
RN84_03430	COG3645	SOS response
RN84_03575	COG3728	DNA packaging
RN84_03680	COG3299	homolog of phage Mu protein gp47
RN84_03755	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RN84_03760	COG2890	protein-(glutamine-N5) methyltransferase activity
RN84_03765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RN84_03770	COG0742	ribosomal rna small subunit methyltransferase
RN84_03790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RN84_03795	COG4589	Belongs to the CDS family
RN84_03800	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RN84_03810	COG0750	zinc metalloprotease
RN84_03815	COG2204	response regulator
RN84_03825	COG0358	DNA primase activity
RN84_03830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RN84_03835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RN84_03855	COG4166	transmembrane transport
RN84_03860	COG0811	peptide transport
RN84_03865	COG0848	biopolymer transport protein
RN84_03880	COG4589	Belongs to the CDS family
RN84_03885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RN84_03890	COG2267	carboxylic ester hydrolase activity
RN84_03900	COG0629	single-stranded DNA binding
RN84_03905	COG2096	Adenosyltransferase
RN84_03915	COG0488	(ABC) transporter
RN84_03925	COG0563	adenylate kinase activity
RN84_03975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RN84_03985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RN84_03990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RN84_03995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RN84_04000	COG0202	RNA polymerase activity
RN84_04005	COG0203	ribosomal protein L17
RN84_04015	COG1864	DNA RNA non-specific endonuclease
RN84_04015	COG3591	Belongs to the peptidase S1B family
RN84_04030	COG2195	Cleaves the N-terminal amino acid of tripeptides
RN84_04050	COG1538	Outer membrane efflux protein
RN84_04060	COG0616	signal peptide processing
RN84_04075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RN84_04075	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RN84_04090	COG2885	chlorophyll binding
RN84_04115	COG3850	Histidine kinase
RN84_04115	COG5002	protein histidine kinase activity
RN84_04120	COG1573	uracil-dna glycosylase
RN84_04125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RN84_04135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RN84_04145	COG0778	Nitroreductase
RN84_04160	COG0672	)-iron permease
RN84_04165	COG2252	PERMEase
RN84_04170	COG2378	regulation of single-species biofilm formation
RN84_04180	COG0859	PFAM glycosyl transferase family 9
RN84_04185	COG3475	LICD family
RN84_04195	COG0726	polysaccharide deacetylase
RN84_04200	COG1216	Glycosyl transferase, family 2
RN84_04230	COG4750	Nucleotidyl transferase
RN84_04250	COG2249	NAD(P)H dehydrogenase (quinone) activity
RN84_04255	COG1733	regulation of RNA biosynthetic process
RN84_04260	COG0517	IMP dehydrogenase activity
RN84_04260	COG0516	GMP reductase activity
RN84_04280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RN84_04285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RN84_04290	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RN84_04320	COG4399	Belongs to the UPF0754 family
RN84_04325	COG2255	four-way junction helicase activity
RN84_04335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RN84_04340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RN84_04355	COG0768	penicillin binding
RN84_04360	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RN84_04365	COG1534	Rna-binding protein
RN84_04370	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RN84_04380	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
RN84_04385	COG3409	Peptidoglycan-binding domain 1 protein
RN84_04385	COG0793	Belongs to the peptidase S41A family
RN84_04390	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RN84_04395	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RN84_04400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RN84_04415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RN84_04470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RN84_04480	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RN84_04520	COG1518	maintenance of DNA repeat elements
RN84_04525	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
RN84_04540	COG0280	phosphate acetyltransferase
RN84_04545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RN84_04550	COG0674	pyruvate-flavodoxin oxidoreductase activity
RN84_04550	COG1013	pyruvate-flavodoxin oxidoreductase activity
RN84_04550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RN84_04550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RN84_04555	COG0039	L-malate dehydrogenase activity
RN84_04565	COG4211	Belongs to the binding-protein-dependent transport system permease family
RN84_04570	COG1129	ABC transporter
RN84_04580	COG1940	carbohydrate kinase activity
RN84_04590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RN84_04595	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RN84_04605	COG1494	fructose-1,6-bisphosphatase
RN84_04615	COG0242	peptide deformylase activity
RN84_04620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RN84_04625	COG0768	penicillin binding
RN84_04630	COG1295	ribonuclease BN
RN84_04645	COG0534	Mate efflux family protein
RN84_04655	COG0210	DNA helicase
RN84_04665	COG3681	Belongs to the UPF0597 family
RN84_04685	COG0363	glucosamine-6-phosphate deaminase activity
RN84_04690	COG1242	4 iron, 4 sulfur cluster binding
RN84_04695	COG2116	formate transmembrane transporter activity
RN84_04715	COG3639	organic phosphonate transmembrane transporter activity
RN84_04720	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RN84_04725	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RN84_04730	COG2731	YhcH YjgK YiaL family protein
RN84_04735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RN84_04740	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RN84_04755	COG1196	nuclear chromosome segregation
RN84_04760	COG4946	Tricorn protease homolog
RN84_04760	COG1506	peptidase
RN84_04760	COG0823	Involved in the tonB-independent uptake of proteins
RN84_04775	COG1704	LemA family
RN84_04780	COG2885	chlorophyll binding
RN84_04785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RN84_04790	COG1022	Amp-dependent synthetase and ligase
RN84_04795	COG4868	Belongs to the UPF0371 family
RN84_04800	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RN84_04805	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RN84_04815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RN84_04825	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
RN84_04835	COG0601	transmembrane transport
RN84_04840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RN84_04845	COG0747	negative chemotaxis
RN84_04850	COG0444	Belongs to the ABC transporter superfamily
RN84_04870	COG1760	l-serine dehydratase
RN84_04880	COG0632	four-way junction helicase activity
RN84_04890	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
RN84_04935	COG3872	metal-dependent enzyme
RN84_04940	COG2208	phosphoserine phosphatase activity
RN84_04945	COG0322	excinuclease ABC activity
RN84_04950	COG1660	Displays ATPase and GTPase activities
RN84_04955	COG0446	pyridine nucleotide-disulphide oxidoreductase
RN84_04995	COG1132	(ABC) transporter
RN84_05025	COG0552	protein localization to endoplasmic reticulum
RN84_05035	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RN84_05040	COG4974	Belongs to the 'phage' integrase family
RN84_05045	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RN84_05050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RN84_05055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RN84_05055	COG0758	DNA mediated transformation
RN84_05065	COG1570	exodeoxyribonuclease VII activity
RN84_05080	COG1473	amidohydrolase
RN84_05100	COG4884	unkown
RN84_05100	COG3831	ATPase activity
RN84_05105	COG1114	Component of the transport system for branched-chain amino acids
RN84_05125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RN84_05155	COG0346	lactoylglutathione lyase activity
RN84_05190	COG2996	Protein conserved in bacteria
RN84_05200	COG1687	branched-chain amino acid
RN84_05205	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RN84_05255	COG0612	Peptidase, M16
RN84_05260	COG0756	dUTP diphosphatase activity
RN84_05265	COG0772	Belongs to the SEDS family
RN84_05275	COG2252	PERMEase
RN84_05280	COG0776	regulation of translation
RN84_05290	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RN84_05300	COG1024	Enoyl-CoA hydratase
RN84_05305	COG1250	3-hydroxyacyl-CoA dehydrogenase
RN84_05320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RN84_05335	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RN84_05340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RN84_05400	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RN84_05405	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RN84_05410	COG1363	Peptidase, m42
RN84_05415	COG0747	negative chemotaxis
RN84_05425	COG5522	Integral membrane protein (intg_mem_TP0381)
RN84_05450	COG1183	phosphatidylcholine synthase activity
RN84_05455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RN84_05460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RN84_05465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RN84_05470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RN84_05475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RN84_05480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RN84_05495	COG0138	bifunctional purine biosynthesis protein purh
RN84_05500	COG0151	Belongs to the GarS family
RN84_05515	COG1757	Na H antiporter
RN84_05535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RN84_05540	COG1797	cobyrinic acid a,c-diamide synthase activity
RN84_05545	COG3177	Filamentation induced by cAMP protein fic
RN84_05570	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
RN84_05585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RN84_05625	COG2875	Belongs to the precorrin methyltransferase family
RN84_05680	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
RN84_05710	COG0745	RESPONSE REGULATOR receiver
RN84_05715	COG3852	Histidine kinase
RN84_05720	COG0405	Gamma-glutamyltransferase
RN84_05755	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RN84_05770	COG0494	nUDIX hydrolase
RN84_05775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RN84_05775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RN84_05780	COG0802	atpase or kinase
RN84_05785	COG1214	PFAM Peptidase M22, glycoprotease
RN84_05815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RN84_05825	COG0501	Belongs to the peptidase M48B family
RN84_05845	COG2190	(PTS) system
RN84_05860	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RN84_05865	COG0406	alpha-ribazole phosphatase activity
RN84_05870	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RN84_05875	COG2003	Belongs to the UPF0758 family
RN84_05880	COG1774	PSP1 C-terminal conserved region
RN84_05885	COG2890	protein-(glutamine-N5) methyltransferase activity
RN84_05890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RN84_05905	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
RN84_05910	COG0517	IMP dehydrogenase activity
RN84_05910	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RN84_05925	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RN84_05930	COG1028	Short-chain dehydrogenase reductase Sdr
RN84_05990	COG1164	Oligoendopeptidase f
RN84_06005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN84_06010	COG1120	ATPase activity
RN84_06020	COG4555	ABC transporter
RN84_06030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RN84_06035	COG0494	nUDIX hydrolase
RN84_06040	COG0616	signal peptide processing
RN84_06050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RN84_06050	COG0248	Ppx GppA phosphatase
RN84_06060	COG0561	phosphatase activity
RN84_06065	COG0037	tRNA processing
RN84_06070	COG0318	PFAM AMP-dependent synthetase and ligase
RN84_06115	COG0058	SHG alpha-glucan phosphorylase activity
RN84_06120	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RN84_06125	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RN84_06130	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RN84_06135	COG0297	glycogen (starch) synthase activity
RN84_06140	COG0500	methyltransferase
RN84_06220	COG4771	TonB-dependent receptor
RN84_06235	COG0577	efflux transmembrane transporter activity
RN84_06240	COG1136	(ABC) transporter
RN84_06245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RN84_06260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RN84_06265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RN84_06275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RN84_06285	COG0776	regulation of translation
RN84_06295	COG2030	dehydratase
RN84_06300	COG2610	gluconate transmembrane transporter activity
RN84_06305	COG4670	ketone body catabolic process
RN84_06310	COG1309	transcriptional regulator
RN84_06340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RN84_06345	COG0406	alpha-ribazole phosphatase activity
RN84_06350	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RN84_06355	COG2385	sporulation resulting in formation of a cellular spore
RN84_06370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN84_06375	COG3976	FMN-binding domain protein
RN84_06375	COG1053	succinate dehydrogenase
RN84_06375	COG0431	NADPH-dependent FMN reductase
RN84_06385	COG1122	ATPase activity
RN84_06400	COG0310	cobalt ion transport
RN84_06405	COG0785	Cytochrome C biogenesis protein
RN84_06415	COG0765	amino acid transport
RN84_06420	COG1126	abc transporter atp-binding protein
RN84_06425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RN84_06435	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
RN84_06445	COG0574	Belongs to the PEP-utilizing enzyme family
RN84_06445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RN84_06450	COG0517	IMP dehydrogenase activity
RN84_06460	COG0786	glutamate:sodium symporter activity
RN84_06465	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RN84_06470	COG2986	histidine ammonia-lyase
RN84_06475	COG1940	carbohydrate kinase activity
RN84_06480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RN84_06490	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RN84_06495	COG2086	electron transfer activity
RN84_06500	COG1960	acyl-CoA dehydrogenase activity
RN84_06510	COG2966	Psort location CytoplasmicMembrane, score
RN84_06520	COG0523	cobalamin synthesis protein
RN84_06530	COG0481	GTPase activity
RN84_06535	COG2502	aspartate--ammonia ligase
RN84_06540	COG1362	aminopeptidase activity
RN84_06560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RN84_06565	COG1120	ATPase activity
RN84_06570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN84_06575	COG4206	TonB-dependent receptor
RN84_06580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RN84_06585	COG1970	mechanosensitive ion channel activity
RN84_06590	COG0482	sulfurtransferase activity
RN84_06605	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RN84_06620	COG1077	Cell shape determining protein MreB Mrl
RN84_06625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RN84_06630	COG1187	pseudouridine synthase activity
RN84_06635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RN84_06640	COG0154	amidase activity
RN84_06645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RN84_06655	COG0252	asparaginase activity
RN84_06695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RN84_06700	COG1480	7TM receptor with intracellular HD hydrolase
RN84_06710	COG1199	ATP-dependent helicase activity
RN84_06715	COG4807	Protein conserved in bacteria
RN84_06725	COG1228	amidohydrolase
RN84_06730	COG3404	Formiminotransferase-cyclodeaminase
RN84_06750	COG5295	Hep Hag repeat protein
RN84_06755	COG1032	radical SAM domain protein
RN84_06760	COG2195	Cleaves the N-terminal amino acid of tripeptides
RN84_06765	COG1323	Belongs to the UPF0348 family
RN84_06775	COG0588	phosphoglycerate mutase activity
RN84_06780	COG0588	phosphoglycerate mutase activity
RN84_06785	COG3177	Filamentation induced by cAMP protein fic
RN84_06800	COG3177	Filamentation induced by cAMP protein fic
RN84_06805	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RN84_06810	COG0716	FMN binding
RN84_06830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RN84_06845	COG1187	pseudouridine synthase activity
RN84_06875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RN84_06885	COG0728	peptidoglycan biosynthetic process
RN84_06890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RN84_06895	COG0196	riboflavin kinase activity
RN84_06905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RN84_06905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RN84_06920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RN84_06920	COG4797	methyltransferase
RN84_06925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RN84_06930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RN84_06935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RN84_06940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RN84_06950	COG1137	ATPase activity
RN84_06960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RN84_07000	COG4145	pantothenate transmembrane transporter activity
RN84_07005	COG1151	hydroxylamine reductase activity
RN84_07025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RN84_07030	COG1162	GTPase activity
RN84_07045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RN84_07050	COG0459	protein refolding
RN84_07060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RN84_07065	COG1373	ATPase (AAA superfamily
RN84_07070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RN84_07075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RN84_07080	COG1121	(ABC) transporter
RN84_07085	COG0803	Belongs to the bacterial solute-binding protein 9 family
RN84_07125	COG0010	Belongs to the arginase family
RN84_07135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RN84_07140	COG2011	ABC-type metal ion transport system permease component
RN84_07165	COG0126	phosphoglycerate kinase activity
RN84_07180	COG0564	pseudouridine synthase activity
RN84_07190	COG1574	metal-dependent hydrolase with the TIM-barrel fold
RN84_07205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RN84_07210	COG0181	hydroxymethylbilane synthase activity
RN84_07260	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RN84_07285	COG3715	PTS system
RN84_07290	COG3716	PTS system mannose fructose sorbose family IID component
RN84_07300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RN84_07310	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RN84_07315	COG1757	Na H antiporter
RN84_07325	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
RN84_07330	COG0427	acetyl-CoA hydrolase
RN84_07340	COG0668	transmembrane transport
RN84_07350	COG0592	DNA-directed DNA polymerase activity
RN84_07360	COG1132	(ABC) transporter
RN84_07380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RN84_07390	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RN84_07395	COG0557	exoribonuclease II activity
RN84_07400	COG1713	HD superfamily hydrolase involved in NAD metabolism
RN84_07415	COG1301	dicarboxylic acid transport
RN84_07420	COG0583	DNA-binding transcription factor activity
RN84_07450	COG1132	(ABC) transporter
RN84_07455	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RN84_07465	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RN84_07470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RN84_07485	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RN84_07495	COG1733	regulation of RNA biosynthetic process
RN84_07510	COG3850	Histidine kinase
RN84_07510	COG5002	protein histidine kinase activity
RN84_07530	COG1136	(ABC) transporter
RN84_07540	COG4953	penicillin-binding protein 1C
RN84_07555	COG0514	ATP-dependent DNA helicase (RecQ)
RN84_07565	COG2304	oxidoreductase activity
RN84_07580	COG0758	DNA mediated transformation
RN84_07605	COG0482	sulfurtransferase activity
RN84_07610	COG1799	cell septum assembly
RN84_07615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RN84_07620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RN84_07625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RN84_07655	COG2610	gluconate transmembrane transporter activity
RN84_07660	COG3048	D-serine ammonia-lyase activity
RN84_07680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RN84_07685	COG2137	regulation of response to DNA damage stimulus
RN84_07690	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RN84_07705	COG0859	PFAM glycosyl transferase family 9
RN84_07715	COG0463	Glycosyl transferase, family 2
RN84_07720	COG0726	polysaccharide deacetylase
RN84_07725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RN84_07730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RN84_07730	COG1648	precorrin-2 dehydrogenase activity
RN84_07740	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RN84_07760	COG2855	membrane
RN84_07780	COG0426	domain, Protein
RN84_07825	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RN84_07840	COG0210	DNA helicase
RN84_07845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RN84_07850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RN84_07860	COG1278	Cold shock
RN84_07870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RN84_07875	COG4667	esterase of the alpha-beta hydrolase superfamily
RN84_07885	COG0018	arginyl-trna synthetase
RN84_07890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RN84_07900	COG0583	DNA-binding transcription factor activity
RN84_07905	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RN84_07920	COG1982	Orn Lys Arg decarboxylase major
RN84_07925	COG2342	PFAM TM1410 hypothetical-related protein
RN84_07945	COG0183	Belongs to the thiolase family
RN84_07950	COG1028	Short-chain dehydrogenase reductase Sdr
RN84_07965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RN84_07975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RN84_07985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RN84_07995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RN84_08000	COG0254	rRNA binding
RN84_08020	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RN84_08025	COG0739	heme binding
RN84_08030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RN84_08035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RN84_08045	COG1309	transcriptional regulator
RN84_08060	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RN84_08070	COG1346	cytolysis
RN84_08080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RN84_08095	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RN84_08100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RN84_08105	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RN84_08110	COG0113	porphobilinogen synthase activity
RN84_08135	COG1592	Rubrerythrin
RN84_08150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RN84_08170	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RN84_08175	COG1914	H( )-stimulated, divalent metal cation uptake system
RN84_08180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RN84_08185	COG1984	allophanate hydrolase subunit 2
RN84_08190	COG0813	purine-nucleoside phosphorylase activity
RN84_08215	COG0813	purine-nucleoside phosphorylase activity
RN84_08220	COG1984	allophanate hydrolase subunit 2
RN84_08225	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RN84_08230	COG1914	H( )-stimulated, divalent metal cation uptake system
RN84_08240	COG0335	large ribosomal subunit rRNA binding
RN84_08250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RN84_08255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RN84_08260	COG0284	orotidine-5'-phosphate decarboxylase activity
RN84_08270	COG0167	dihydroorotate dehydrogenase activity
RN84_08275	COG0543	2 iron, 2 sulfur cluster binding
RN84_08285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RN84_08290	COG0505	Belongs to the CarA family
RN84_08295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RN84_08300	COG0540	Belongs to the ATCase OTCase family
RN84_08305	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RN84_08320	COG4804	nuclease activity
RN84_08355	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RN84_08360	COG2926	Belongs to the UPF0265 family
RN84_08365	COG0205	6-phosphofructokinase activity
RN84_08370	COG0825	malonyl-CoA metabolic process
RN84_08375	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RN84_08385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RN84_08390	COG0180	Tryptophanyl-tRNA synthetase
RN84_08415	COG4608	Belongs to the ABC transporter superfamily
RN84_08420	COG0444	Belongs to the ABC transporter superfamily
RN84_08435	COG0747	negative chemotaxis
RN84_08450	COG0726	polysaccharide deacetylase
RN84_08460	COG0561	phosphatase activity
RN84_08475	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
RN84_08485	COG2342	PFAM TM1410 hypothetical-related protein
RN84_08500	COG0438	transferase activity, transferring glycosyl groups
RN84_08520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RN84_08525	COG1176	ABC-type spermidine putrescine transport system, permease component I
RN84_08530	COG3842	ATPase activity
RN84_08535	COG1840	ABC-type Fe3 transport system, periplasmic component
RN84_08540	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RN84_08540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RN84_08555	COG0681	Belongs to the peptidase S26 family
RN84_08565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RN84_08575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RN84_08590	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RN84_08595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RN84_08600	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RN84_08605	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RN84_08610	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RN84_08615	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RN84_08620	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RN84_08630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RN84_08665	COG1490	D-aminoacyl-tRNA deacylase activity
RN84_08670	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RN84_08675	COG0688	phosphatidylethanolamine metabolic process
RN84_08690	COG0116	Belongs to the methyltransferase superfamily
RN84_08700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RN84_08705	COG2056	Na+-H+ antiporter family
RN84_08745	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RN84_08750	COG0598	Magnesium transport protein CorA
RN84_08760	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RN84_08765	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RN84_08770	COG1115	amino acid carrier protein
RN84_08775	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RN84_08780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RN84_08785	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RN84_08800	COG3588	fructose-bisphosphate aldolase
RN84_08805	COG0326	Molecular chaperone. Has ATPase activity
RN84_08815	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
RN84_08820	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
RN84_08825	COG2337	Toxic component of a toxin-antitoxin (TA) module
RN84_08865	COG0133	tryptophan synthase activity
RN84_08870	COG2207	Transcriptional regulator
RN84_08870	COG3708	Transcriptional regulator
RN84_08880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RN84_08880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RN84_08885	COG0602	queuosine metabolic process
RN84_08890	COG1328	CTP reductase activity
RN84_08890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RN84_08895	COG3842	ATPase activity
RN84_08900	COG1176	ABC-type spermidine putrescine transport system, permease component I
RN84_08930	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
RN84_08940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN84_08945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RN84_08950	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RN84_08955	COG0124	histidyl-tRNA synthetase
RN84_08960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RN84_08980	COG3958	Transketolase
RN84_08985	COG3959	Transketolase, thiamine diphosphate binding domain
RN84_09000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RN84_09010	COG1837	Belongs to the UPF0109 family
RN84_09015	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RN84_09020	COG0336	Belongs to the RNA methyltransferase TrmD family
RN84_09025	COG4752	Belongs to the RNA methyltransferase TrmD family
RN84_09045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RN84_09055	COG1283	sodium-dependent phosphate transmembrane transporter activity
RN84_09065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RN84_09070	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RN84_09075	COG1024	Enoyl-CoA hydratase
RN84_09080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RN84_09090	COG0497	DNA recombination
RN84_09095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RN84_09130	COG0640	Transcriptional regulator
RN84_09140	COG2217	Heavy metal translocating P-type atpase
RN84_09145	COG1288	antiporter activity
RN84_09210	COG2217	Heavy metal translocating P-type atpase
RN84_09215	COG2217	Heavy metal translocating P-type atpase
RN84_09230	COG0569	domain protein
RN84_09240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RN84_09255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RN84_09260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RN84_09265	COG1116	anion transmembrane transporter activity
RN84_09290	COG1349	DNA-binding transcription factor activity
RN84_09295	COG3395	kinase activity
RN84_09300	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RN84_09305	COG2610	gluconate transmembrane transporter activity
RN84_09310	COG0556	nucleotide-excision repair
RN84_09320	COG2211	Major facilitator Superfamily
RN84_09325	COG1966	Carbon starvation protein
RN84_09330	COG3275	phosphorelay sensor kinase activity
RN84_09335	COG3279	Response regulator of the LytR AlgR family
RN84_09340	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RN84_09350	COG4221	oxidoreductase activity
RN84_09355	COG1285	pathogenesis
RN84_09360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RN84_09365	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RN84_09390	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
RN84_09395	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
RN84_09400	COG1924	4 iron, 4 sulfur cluster binding
RN84_09405	COG0786	glutamate:sodium symporter activity
RN84_09410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RN84_09415	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RN84_09420	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RN84_09425	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
RN84_09430	COG0511	ligase activity, forming carbon-carbon bonds
RN84_09430	COG5016	pyruvate
RN84_09455	COG4172	Belongs to the ABC transporter superfamily
RN84_09460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RN84_09465	COG0601	transmembrane transport
RN84_09470	COG0747	negative chemotaxis
RN84_09480	COG2972	Histidine kinase
RN84_09490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RN84_09490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RN84_09495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RN84_09500	COG0785	Cytochrome C biogenesis protein
RN84_09520	COG0579	oxidoreductase
RN84_09550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RN84_09555	COG2894	cell division
RN84_09560	COG0850	regulation of cytokinetic process
RN84_09565	COG2070	2-Nitropropane dioxygenase
RN84_09590	COG1160	GTP binding
RN84_09620	COG3023	N-Acetylmuramoyl-L-alanine amidase
RN84_09625	COG0646	methionine synthase
RN84_09625	COG1410	methionine synthase
RN84_09630	COG0534	Mate efflux family protein
RN84_09635	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
RN84_09640	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RN84_09645	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RN84_09660	COG1242	4 iron, 4 sulfur cluster binding
RN84_09665	COG0571	ribonuclease III activity
RN84_09670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RN84_09675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RN84_09680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RN84_09685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RN84_09690	COG0416	fatty acid biosynthetic process
RN84_09710	COG2831	hemolysin activation secretion protein
RN84_09715	COG4988	ABC transporter
RN84_09720	COG1132	(ABC) transporter
RN84_09750	COG0305	Participates in initiation and elongation during chromosome replication
RN84_09755	COG0359	binds to the 23S rRNA
RN84_09765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RN84_09780	COG0848	biopolymer transport protein
RN84_09785	COG0811	peptide transport
RN84_09805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RN84_09810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RN84_09815	COG2376	Dihydroxyacetone kinase
RN84_09850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RN84_09865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RN84_09870	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RN84_09880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RN84_09890	COG4865	methylaspartate mutase activity
RN84_09900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RN84_09905	COG2031	fatty acid transporter
RN84_09915	COG1757	Na H antiporter
RN84_09925	COG5012	cobalamin binding
RN84_09930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RN84_09945	COG1509	lysine 2,3-aminomutase activity
RN84_09950	COG0604	alcohol dehydrogenase
RN84_09955	COG3246	L-lysine catabolic process to acetate
RN84_09960	COG1607	acyl-coa hydrolase
RN84_10000	COG0537	adenosine 5'-monophosphoramidase activity
RN84_10005	COG0698	ribose 5-phosphate isomerase
RN84_10015	COG0504	CTP synthase activity
RN84_10020	COG2252	PERMEase
RN84_10030	COG0268	Binds directly to 16S ribosomal RNA
RN84_10050	COG1272	protein, Hemolysin III
RN84_10070	COG0584	glycerophosphoryl diester phosphodiesterase
RN84_10080	COG2992	FlgJ-related protein
RN84_10100	COG1129	ABC transporter
RN84_10125	COG0446	pyridine nucleotide-disulphide oxidoreductase
RN84_10130	COG1733	regulation of RNA biosynthetic process
RN84_10140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RN84_10145	COG1739	Uncharacterized protein family UPF0029
RN84_10150	COG0584	glycerophosphoryl diester phosphodiesterase
RN84_10155	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RN84_10165	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RN84_10175	COG1418	mRNA catabolic process
RN84_10195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RN84_10200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RN84_10205	COG2226	methyltransferase
RN84_10210	COG0482	sulfurtransferase activity
RN84_10230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RN84_10235	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RN84_10240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN84_10240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN84_10240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RN84_10245	COG1461	Dihydroxyacetone kinase
RN84_10255	COG1546	Belongs to the CinA family
RN84_10255	COG1058	Belongs to the CinA family
RN84_10260	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RN84_10270	COG0237	dephospho-CoA kinase activity
RN84_10320	COG0534	Mate efflux family protein
RN84_10325	COG0542	response to heat
RN84_10330	COG2964	Protein conserved in bacteria
RN84_10340	COG0733	neurotransmitter:sodium symporter activity
RN84_10360	COG0006	proline dipeptidase activity
RN84_10370	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RN84_10380	COG1115	amino acid carrier protein
RN84_10450	COG1120	ATPase activity
RN84_10455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN84_10465	COG4206	TonB-dependent receptor
RN84_10470	COG0494	nUDIX hydrolase
RN84_10475	COG0251	oxidation-reduction process
RN84_10485	COG0513	Belongs to the DEAD box helicase family
RN84_10490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RN84_10495	COG0037	tRNA processing
RN84_10500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RN84_10505	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RN84_10525	COG0450	alkyl hydroperoxide reductase
RN84_10535	COG4452	Inner membrane protein CreD
RN84_10545	COG1802	Transcriptional regulator
RN84_10550	COG3033	Beta-eliminating lyase
RN84_10555	COG0733	neurotransmitter:sodium symporter activity
RN84_10565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RN84_10570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RN84_10575	COG0009	L-threonylcarbamoyladenylate synthase
RN84_10590	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RN84_10615	COG1268	BioY protein
RN84_10620	COG1122	ATPase activity
RN84_10625	COG1122	ATPase activity
RN84_10635	COG0386	Belongs to the glutathione peroxidase family
RN84_10640	COG1125	glycine betaine transport
RN84_10645	COG1174	glycine betaine transport
RN84_10655	COG0525	valine-tRNA ligase activity
RN84_10680	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RN84_10685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RN84_10690	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RN84_10695	COG0740	serine-type endopeptidase activity
RN84_10700	COG0544	peptidyl-prolyl cis-trans isomerase activity
RN84_10705	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RN84_10705	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RN84_10710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RN84_10715	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RN84_10725	COG0195	Participates in both transcription termination and antitermination
RN84_10730	COG0779	Required for maturation of 30S ribosomal subunits
RN84_10750	COG0813	purine-nucleoside phosphorylase activity
RN84_10755	COG1984	allophanate hydrolase subunit 2
RN84_10760	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RN84_10765	COG1914	H( )-stimulated, divalent metal cation uptake system
RN84_10770	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RN84_10775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RN84_10775	COG2755	lipolytic protein G-D-S-L family
RN84_10780	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
RN84_10795	COG0194	GDP metabolic process
RN84_10805	COG1561	YicC-like family, N-terminal region
RN84_10810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RN84_10815	COG0085	RNA polymerase activity
RN84_10820	COG0222	ribosome binding
RN84_10825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RN84_10830	COG0081	regulation of translation
RN84_10835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RN84_10840	COG0250	Participates in transcription elongation, termination and antitermination
RN84_10855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RN84_10860	COG0735	belongs to the Fur family