locus-tag	class	description
IGS75_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IGS75_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IGS75_00030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IGS75_00035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IGS75_00040	COG0247	lactate metabolic process
IGS75_00040	COG0277	FAD linked oxidase domain protein
IGS75_00055	COG3104	oligopeptide transport
IGS75_00070	COG0321	lipoyl(octanoyl) transferase activity
IGS75_00070	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IGS75_00075	COG0084	hydrolase, TatD family'
IGS75_00080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGS75_00090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IGS75_00095	COG1686	Belongs to the peptidase S11 family
IGS75_00100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IGS75_00105	COG2951	lytic endotransglycosylase activity
IGS75_00125	COG1968	undecaprenyl-diphosphatase activity
IGS75_00130	COG0531	amino acid
IGS75_00155	COG2890	protein-(glutamine-N5) methyltransferase activity
IGS75_00165	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IGS75_00170	COG0124	histidyl-tRNA synthetase
IGS75_00175	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IGS75_00185	COG2070	2-Nitropropane dioxygenase
IGS75_00195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IGS75_00210	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IGS75_00240	COG0321	lipoyl(octanoyl) transferase activity
IGS75_00250	COG0271	Belongs to the BolA IbaG family
IGS75_00255	COG0484	heat shock protein binding
IGS75_00285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IGS75_00295	COG3300	MHYT domain
IGS75_00295	COG5001	Diguanylate cyclase
IGS75_00305	COG1278	Cold shock
IGS75_00310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IGS75_00315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS75_00325	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IGS75_00335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IGS75_00340	COG0606	chelatase, subunit chli
IGS75_00345	COG0626	cystathionine gamma-synthase activity
IGS75_00350	COG2897	thiosulfate sulfurtransferase activity
IGS75_00355	COG0628	permease
IGS75_00365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IGS75_00370	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IGS75_00375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IGS75_00385	COG1381	Involved in DNA repair and RecF pathway recombination
IGS75_00390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IGS75_00395	COG0052	Belongs to the universal ribosomal protein uS2 family
IGS75_00405	COG1136	(ABC) transporter
IGS75_00410	COG4591	ABC-type transport system involved in lipoprotein release permease component
IGS75_00415	COG0442	prolyl-tRNA aminoacylation
IGS75_00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IGS75_00440	COG0776	regulation of translation
IGS75_00450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IGS75_00455	COG0740	serine-type endopeptidase activity
IGS75_00460	COG0544	peptidyl-prolyl cis-trans isomerase activity
IGS75_00470	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IGS75_00470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IGS75_00480	COG0513	Belongs to the DEAD box helicase family
IGS75_00485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IGS75_00490	COG0316	Belongs to the HesB IscA family
IGS75_00495	COG2151	metal-sulfur cluster biosynthetic enzyme
IGS75_00500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IGS75_00505	COG0719	Fe-S assembly protein
IGS75_00510	COG0396	ATPase activity
IGS75_00515	COG0719	Fe-S assembly protein
IGS75_00520	COG1959	2 iron, 2 sulfur cluster binding
IGS75_00525	COG2733	membrane
IGS75_00540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IGS75_00545	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IGS75_00550	COG5265	(ABC) transporter
IGS75_00565	COG0628	permease
IGS75_00580	COG0776	regulation of translation
IGS75_00585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS75_00590	COG0416	fatty acid biosynthetic process
IGS75_00595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IGS75_00615	COG0745	RESPONSE REGULATOR receiver
IGS75_00625	COG0242	peptide deformylase activity
IGS75_00630	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IGS75_00635	COG1505	serine-type exopeptidase activity
IGS75_00640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IGS75_00660	COG1522	sequence-specific DNA binding
IGS75_00665	COG0492	ferredoxin-NADP+ reductase activity
IGS75_00675	COG0776	regulation of translation
IGS75_00680	COG0616	signal peptide processing
IGS75_00685	COG4957	zinc ion binding
IGS75_00700	COG1289	transmembrane transporter activity
IGS75_00705	COG3622	Belongs to the hyi family
IGS75_00710	COG2610	gluconate transmembrane transporter activity
IGS75_00715	COG0235	Class ii aldolase
IGS75_00720	COG3395	kinase activity
IGS75_00725	COG2084	Dehydrogenase
IGS75_00780	COG2706	6-phosphogluconolactonase activity
IGS75_00795	COG2271	Major facilitator Superfamily
IGS75_00830	COG3081	Nucleoid-associated protein
IGS75_00850	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IGS75_00860	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IGS75_00885	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IGS75_00890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IGS75_00895	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IGS75_00900	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IGS75_00910	COG3750	Belongs to the UPF0335 family
IGS75_00915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IGS75_00925	COG0657	acetylesterase activity
IGS75_00935	COG2001	Belongs to the MraZ family
IGS75_00940	COG0275	rRNA processing
IGS75_00955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IGS75_00960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IGS75_00965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IGS75_00970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IGS75_00980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IGS75_00985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IGS75_00990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IGS75_00995	COG1181	Belongs to the D-alanine--D-alanine ligase family
IGS75_01000	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IGS75_01005	COG0849	cell division
IGS75_01015	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IGS75_01020	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IGS75_01030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IGS75_01035	COG1253	flavin adenine dinucleotide binding
IGS75_01040	COG1335	isochorismatase
IGS75_01060	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IGS75_01065	COG2814	Major facilitator Superfamily
IGS75_01075	COG0328	RNA-DNA hybrid ribonuclease activity
IGS75_01080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IGS75_01085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IGS75_01095	COG1297	OPT oligopeptide transporter protein
IGS75_01105	COG2096	Adenosyltransferase
IGS75_01135	COG0436	Aminotransferase
IGS75_01145	COG0473	3-isopropylmalate dehydrogenase activity
IGS75_01150	COG0066	3-isopropylmalate dehydratase activity
IGS75_01155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IGS75_01160	COG0335	large ribosomal subunit rRNA binding
IGS75_01165	COG0336	Belongs to the RNA methyltransferase TrmD family
IGS75_01170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IGS75_01175	COG0228	four-way junction DNA binding
IGS75_01180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IGS75_01210	COG1733	regulation of RNA biosynthetic process
IGS75_01265	COG0513	Belongs to the DEAD box helicase family
IGS75_01270	COG0778	Nitroreductase
IGS75_01275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IGS75_01275	COG2813	Specifically methylates the guanine in position
IGS75_01280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IGS75_01470	COG1196	nuclear chromosome segregation
IGS75_01470	COG0739	heme binding
IGS75_01470	COG0741	lytic transglycosylase activity
IGS75_01590	COG0435	Glutathione S-transferase
IGS75_01595	COG0400	carboxylic ester hydrolase activity
IGS75_01600	COG0583	DNA-binding transcription factor activity
IGS75_01640	COG1692	metallophosphoesterase
IGS75_01645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IGS75_01685	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IGS75_01690	COG1509	lysine 2,3-aminomutase activity
IGS75_01700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IGS75_01705	COG0483	inositol monophosphate 1-phosphatase activity
IGS75_01725	COG0481	GTPase activity
IGS75_01735	COG2252	PERMEase
IGS75_01760	COG1722	exodeoxyribonuclease VII activity
IGS75_01770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IGS75_01775	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IGS75_01780	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IGS75_01785	COG0137	argininosuccinate synthase activity
IGS75_01790	COG0545	Peptidyl-prolyl cis-trans isomerase
IGS75_01805	COG0180	Tryptophanyl-tRNA synthetase
IGS75_01810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IGS75_01815	COG0072	phenylalanine-tRNA ligase activity
IGS75_01815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGS75_01820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IGS75_01825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IGS75_01830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IGS75_01835	COG4993	Dehydrogenase
IGS75_01850	COG2166	iron-sulfur cluster assembly
IGS75_01875	COG2884	Cell division ATP-binding protein ftsE
IGS75_01900	COG1271	oxidase subunit
IGS75_01905	COG1294	oxidase, subunit
IGS75_01915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGS75_01925	COG0688	phosphatidylethanolamine metabolic process
IGS75_01930	COG1183	phosphatidylcholine synthase activity
IGS75_01935	COG1940	carbohydrate kinase activity
IGS75_01940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS75_01945	COG0649	NAD binding
IGS75_01970	COG0656	L-ascorbic acid biosynthetic process
IGS75_01985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IGS75_01995	COG1218	3'(2'),5'-bisphosphate nucleotidase
IGS75_02000	COG0009	L-threonylcarbamoyladenylate synthase
IGS75_02020	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IGS75_02025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IGS75_02030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IGS75_02035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IGS75_02040	COG0359	binds to the 23S rRNA
IGS75_02045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IGS75_02050	COG0360	Binds together with S18 to 16S ribosomal RNA
IGS75_02060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IGS75_02065	COG0358	DNA primase activity
IGS75_02075	COG2202	Pas domain
IGS75_02075	COG3920	Histidine kinase
IGS75_02090	COG2084	Dehydrogenase
IGS75_02105	COG0505	Belongs to the CarA family
IGS75_02110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IGS75_02120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IGS75_02125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IGS75_02135	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IGS75_02140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGS75_02145	COG3237	CsbD-like
IGS75_02150	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IGS75_02160	COG0793	Belongs to the peptidase S41A family
IGS75_02170	COG0494	nUDIX hydrolase
IGS75_02175	COG1132	(ABC) transporter
IGS75_02190	COG0714	Associated with various cellular activities
IGS75_02215	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IGS75_02220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IGS75_02240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IGS75_02265	COG2814	Major facilitator Superfamily
IGS75_02270	COG0203	ribosomal protein L17
IGS75_02275	COG0202	RNA polymerase activity
IGS75_02280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IGS75_02285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IGS75_02290	COG0563	adenylate kinase activity
IGS75_02300	COG0200	Binds to the 23S rRNA
IGS75_02305	COG1841	ribosomal large subunit assembly
IGS75_02310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IGS75_02315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IGS75_02320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IGS75_02325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IGS75_02330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IGS75_02335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IGS75_02340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IGS75_02345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IGS75_02350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IGS75_02355	COG0255	Belongs to the universal ribosomal protein uL29 family
IGS75_02360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IGS75_02365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IGS75_02370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IGS75_02375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IGS75_02380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IGS75_02385	COG0089	rRNA binding
IGS75_02390	COG0088	Forms part of the polypeptide exit tunnel
IGS75_02395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IGS75_02400	COG0051	transcription antitermination factor activity, RNA binding
IGS75_02405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IGS75_02410	COG0049	tRNA binding
IGS75_02415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IGS75_02420	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IGS75_02425	COG0085	RNA polymerase activity
IGS75_02430	COG0222	ribosome binding
IGS75_02435	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IGS75_02440	COG0081	regulation of translation
IGS75_02445	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IGS75_02475	COG1322	Protein conserved in bacteria
IGS75_02485	COG2081	HI0933 family
IGS75_02495	COG0850	regulation of cytokinetic process
IGS75_02505	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IGS75_02540	COG0495	leucyl-tRNA aminoacylation
IGS75_02555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IGS75_02565	COG0679	Auxin Efflux Carrier
IGS75_02570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IGS75_02575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IGS75_02590	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IGS75_02595	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IGS75_02605	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IGS75_02610	COG1766	The M ring may be actively involved in energy transduction
IGS75_02615	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IGS75_02630	COG0138	bifunctional purine biosynthesis protein purh
IGS75_02635	COG1988	membrane-bound metal-dependent
IGS75_02640	COG0800	Aldolase
IGS75_02645	COG0129	dihydroxy-acid dehydratase activity
IGS75_02660	COG0439	Biotin carboxylase
IGS75_02665	COG0511	ligase activity, forming carbon-carbon bonds
IGS75_02670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IGS75_02680	COG1295	ribonuclease BN
IGS75_02705	COG0314	molybdopterin synthase activity
IGS75_02710	COG0315	cyclic pyranopterin monophosphate synthase activity
IGS75_02710	COG0746	molybdenum cofactor guanylyltransferase activity
IGS75_02715	COG0315	cyclic pyranopterin monophosphate synthase activity
IGS75_02720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IGS75_02725	COG0303	'Molybdopterin
IGS75_02740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IGS75_02745	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IGS75_02750	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IGS75_02770	COG0697	spore germination
IGS75_02785	COG0659	secondary active sulfate transmembrane transporter activity
IGS75_02795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IGS75_02800	COG1923	regulation of RNA biosynthetic process
IGS75_02805	COG2204	response regulator
IGS75_02830	COG0167	dihydroorotate dehydrogenase activity
IGS75_02835	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IGS75_02835	COG3264	Mechanosensitive ion channel
IGS75_02860	COG0131	Imidazoleglycerol-phosphate dehydratase
IGS75_02870	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IGS75_02875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IGS75_02880	COG0107	imidazoleglycerol-phosphate synthase activity
IGS75_02885	COG0140	phosphoribosyl-ATP diphosphatase activity
IGS75_02910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IGS75_02920	COG2072	flavoprotein involved in K transport
IGS75_02950	COG0789	Transcriptional regulator
IGS75_02950	COG4978	Transcriptional regulator
IGS75_02995	COG2207	Transcriptional regulator
IGS75_03015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGS75_03025	COG0583	DNA-binding transcription factor activity
IGS75_03045	COG3038	cytochrome b561
IGS75_03060	COG0583	DNA-binding transcription factor activity
IGS75_03065	COG1902	pentaerythritol trinitrate reductase activity
IGS75_03105	COG1012	belongs to the aldehyde dehydrogenase family
IGS75_03110	COG1252	NADH dehydrogenase
IGS75_03130	COG2308	Evidence 4 Homologs of previously reported genes of
IGS75_03140	COG1349	DNA-binding transcription factor activity
IGS75_03175	COG0583	DNA-binding transcription factor activity
IGS75_03180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IGS75_03195	COG0402	S-adenosylhomocysteine deaminase activity
IGS75_03205	COG0765	amino acid transport
IGS75_03210	COG1126	abc transporter atp-binding protein
IGS75_03215	COG4948	Mandelate Racemase Muconate Lactonizing
IGS75_03235	COG4172	Belongs to the ABC transporter superfamily
IGS75_03240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS75_03245	COG0601	transmembrane transport
IGS75_03255	COG2072	flavoprotein involved in K transport
IGS75_03260	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_03290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IGS75_03295	COG1902	pentaerythritol trinitrate reductase activity
IGS75_03300	COG0640	Transcriptional regulator
IGS75_03315	COG0564	pseudouridine synthase activity
IGS75_03325	COG0126	phosphoglycerate kinase activity
IGS75_03355	COG1522	sequence-specific DNA binding
IGS75_03370	COG4993	Dehydrogenase
IGS75_03380	COG1393	Belongs to the ArsC family
IGS75_03390	COG0659	secondary active sulfate transmembrane transporter activity
IGS75_03395	COG2824	Alkylphosphonate utilization operon protein PhnA
IGS75_03405	COG0848	biopolymer transport protein
IGS75_03435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGS75_03460	COG3128	pkhd-type hydroxylase
IGS75_03465	COG5001	Diguanylate cyclase
IGS75_03480	COG1309	transcriptional regulator
IGS75_03510	COG3620	sequence-specific DNA binding
IGS75_03525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGS75_03525	COG3453	Protein conserved in bacteria
IGS75_03535	COG0450	alkyl hydroperoxide reductase
IGS75_03550	COG1609	Transcriptional regulator
IGS75_03565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IGS75_03570	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IGS75_03575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS75_03580	COG2010	Cytochrome c
IGS75_03580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS75_03600	COG0297	glycogen (starch) synthase activity
IGS75_03610	COG0612	Peptidase, M16
IGS75_03620	COG1215	transferase activity, transferring glycosyl groups
IGS75_03630	COG0539	negative regulation of cytoplasmic translation
IGS75_03635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IGS75_03640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IGS75_03650	COG3161	chorismate lyase activity
IGS75_03655	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_03660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IGS75_03665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IGS75_03670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IGS75_03685	COG0024	Methionine aminopeptidase
IGS75_03690	COG1686	Belongs to the peptidase S11 family
IGS75_03695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IGS75_03715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS75_03720	COG3394	polysaccharide catabolic process
IGS75_03725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IGS75_03740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IGS75_03750	COG1253	flavin adenine dinucleotide binding
IGS75_03765	COG1706	bacterial-type flagellum-dependent cell motility
IGS75_03790	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IGS75_03810	COG0802	atpase or kinase
IGS75_03815	COG0438	transferase activity, transferring glycosyl groups
IGS75_03820	COG0492	ferredoxin-NADP+ reductase activity
IGS75_03825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS75_03840	COG1217	gtp-binding protein TYPA
IGS75_03845	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IGS75_03850	COG2746	aminoglycoside 3-N-acetyltransferase activity
IGS75_03855	COG4774	siderophore transport
IGS75_03860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IGS75_03870	COG0656	L-ascorbic acid biosynthetic process
IGS75_03875	COG0784	Response regulator, receiver
IGS75_03875	COG4191	Histidine kinase
IGS75_03880	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_03885	COG1289	transmembrane transporter activity
IGS75_03890	COG0583	DNA-binding transcription factor activity
IGS75_03895	COG2814	Major facilitator Superfamily
IGS75_03915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS75_03925	COG4608	Belongs to the ABC transporter superfamily
IGS75_03930	COG0444	Belongs to the ABC transporter superfamily
IGS75_03935	COG0601	transmembrane transport
IGS75_03940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS75_03950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IGS75_03960	COG2217	Heavy metal translocating P-type atpase
IGS75_03970	COG2217	Heavy metal translocating P-type atpase
IGS75_03980	COG2132	Multicopper oxidase
IGS75_03995	COG1937	Protein conserved in bacteria
IGS75_04020	COG0500	methyltransferase
IGS75_04025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IGS75_04035	COG2814	Major facilitator Superfamily
IGS75_04065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGS75_04120	COG0745	RESPONSE REGULATOR receiver
IGS75_04130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IGS75_04135	COG0581	inorganic phosphate transmembrane transporter activity
IGS75_04140	COG0573	inorganic phosphate transmembrane transporter activity
IGS75_04145	COG0783	Belongs to the Dps family
IGS75_04200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IGS75_04215	COG0156	8-amino-7-oxononanoate synthase activity
IGS75_04225	COG4106	trans-aconitate 2-methyltransferase activity
IGS75_04230	COG4106	trans-aconitate 2-methyltransferase activity
IGS75_04230	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IGS75_04235	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IGS75_04240	COG2943	transferase activity, transferring hexosyl groups
IGS75_04270	COG1566	PFAM secretion protein HlyD family protein
IGS75_04290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IGS75_04310	COG4974	Belongs to the 'phage' integrase family
IGS75_04330	COG0004	ammonium transporteR
IGS75_04335	COG0347	Belongs to the P(II) protein family
IGS75_04345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IGS75_04380	COG0488	(ABC) transporter
IGS75_04390	COG1289	transmembrane transporter activity
IGS75_04400	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IGS75_04430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IGS75_04435	COG2835	tetraacyldisaccharide 4'-kinase activity
IGS75_04440	COG0840	transmembrane signaling receptor activity
IGS75_04455	COG1396	sequence-specific DNA binding
IGS75_04460	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IGS75_04475	COG4957	zinc ion binding
IGS75_04495	COG0778	Nitroreductase
IGS75_04515	COG0191	fructose-bisphosphate aldolase activity
IGS75_04530	COG2814	Major facilitator Superfamily
IGS75_04535	COG1566	PFAM secretion protein HlyD family protein
IGS75_04540	COG1573	uracil-dna glycosylase
IGS75_04550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IGS75_04570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IGS75_04580	COG1760	l-serine dehydratase
IGS75_04595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGS75_04605	COG0666	response to abiotic stimulus
IGS75_04605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IGS75_04610	COG1187	pseudouridine synthase activity
IGS75_04615	COG0742	ribosomal rna small subunit methyltransferase
IGS75_04625	COG0564	pseudouridine synthase activity
IGS75_04645	COG2814	Major facilitator Superfamily
IGS75_04660	COG0735	belongs to the Fur family
IGS75_04665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IGS75_04680	COG1660	Displays ATPase and GTPase activities
IGS75_04685	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IGS75_04700	COG2205	protein histidine kinase activity
IGS75_04705	COG0745	RESPONSE REGULATOR receiver
IGS75_04710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IGS75_04715	COG0859	PFAM glycosyl transferase family 9
IGS75_04725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IGS75_04730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IGS75_04755	COG2205	protein histidine kinase activity
IGS75_04760	COG0745	RESPONSE REGULATOR receiver
IGS75_04775	COG1643	Atp-dependent helicase
IGS75_04780	COG1278	Cold shock
IGS75_04785	COG0778	Nitroreductase
IGS75_04790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IGS75_04800	COG2814	Major facilitator Superfamily
IGS75_04810	COG1695	Transcriptional regulator
IGS75_04830	COG1054	Belongs to the UPF0176 family
IGS75_04840	COG0402	S-adenosylhomocysteine deaminase activity
IGS75_04855	COG2351	hydroxyisourate hydrolase activity
IGS75_04870	COG2072	flavoprotein involved in K transport
IGS75_04910	COG0668	transmembrane transport
IGS75_04945	COG2814	Major facilitator Superfamily
IGS75_04950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IGS75_04965	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IGS75_04970	COG2814	Major facilitator Superfamily
IGS75_04975	COG0529	Catalyzes the synthesis of activated sulfate
IGS75_04975	COG2895	sulfate adenylyltransferase (ATP) activity
IGS75_04980	COG0175	sulfate reduction
IGS75_04985	COG0175	sulfate reduction
IGS75_04995	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IGS75_05000	COG1842	Phage shock protein A
IGS75_05020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IGS75_05025	COG1127	ABC transporter
IGS75_05095	COG0534	Mate efflux family protein
IGS75_05100	COG1749	Flagellar hook protein flgE
IGS75_05115	COG0326	Molecular chaperone. Has ATPase activity
IGS75_05135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IGS75_05150	COG1956	GAF domain-containing protein
IGS75_05160	COG0246	Mannitol dehydrogenase
IGS75_05165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IGS75_05170	COG0717	Belongs to the dCTP deaminase family
IGS75_05185	COG0438	transferase activity, transferring glycosyl groups
IGS75_05190	COG4993	Dehydrogenase
IGS75_05195	COG4993	Dehydrogenase
IGS75_05205	COG0443	Heat shock 70 kDa protein
IGS75_05210	COG0484	heat shock protein binding
IGS75_05215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IGS75_05220	COG1959	2 iron, 2 sulfur cluster binding
IGS75_05225	COG1017	nitric oxide dioxygenase activity
IGS75_05225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IGS75_05230	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IGS75_05235	COG1733	regulation of RNA biosynthetic process
IGS75_05240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IGS75_05250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IGS75_05255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IGS75_05275	COG0681	Belongs to the peptidase S26 family
IGS75_05290	COG1621	beta-fructofuranosidase activity
IGS75_05295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IGS75_05305	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IGS75_05310	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IGS75_05315	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IGS75_05330	COG0657	acetylesterase activity
IGS75_05355	COG1957	nucleoside hydrolase
IGS75_05370	COG0300	oxidoreductase activity
IGS75_05375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IGS75_05385	COG4786	Flagellar basal body rod
IGS75_05420	COG5001	Diguanylate cyclase
IGS75_05425	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IGS75_05440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IGS75_05465	COG1538	Outer membrane efflux protein
IGS75_05475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGS75_05480	COG3047	cAMP biosynthetic process
IGS75_05485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGS75_05495	COG0415	Belongs to the DNA photolyase family
IGS75_05505	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IGS75_05505	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IGS75_05510	COG0307	riboflavin synthase, alpha
IGS75_05515	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGS75_05515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGS75_05520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IGS75_05530	COG0535	radical SAM domain protein
IGS75_05540	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IGS75_05545	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IGS75_05560	COG0194	GDP metabolic process
IGS75_05565	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IGS75_05570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IGS75_05590	COG0513	Belongs to the DEAD box helicase family
IGS75_05595	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IGS75_05600	COG0424	maF-like protein
IGS75_05605	COG1530	ribonuclease E activity
IGS75_05610	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IGS75_05640	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IGS75_05675	COG0420	3'-5' exonuclease activity
IGS75_05680	COG4717	serine-type aminopeptidase activity
IGS75_05695	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_05735	COG0667	Aldo Keto reductase
IGS75_05740	COG0656	L-ascorbic acid biosynthetic process
IGS75_05750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IGS75_05755	COG0629	single-stranded DNA binding
IGS75_05765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IGS75_05770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IGS75_05810	COG0697	spore germination
IGS75_05830	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_05835	COG1981	membrane
IGS75_05840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IGS75_05845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IGS75_05850	COG0424	maF-like protein
IGS75_05890	COG2814	Major facilitator Superfamily
IGS75_05920	COG1091	dTDP-4-dehydrorhamnose reductase activity
IGS75_05925	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IGS75_05980	COG0357	Ribosomal RNA small subunit methyltransferase G
IGS75_05985	COG0445	tRNA wobble uridine modification
IGS75_05990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IGS75_05995	COG2010	Cytochrome c
IGS75_06000	COG2010	Cytochrome c
IGS75_06000	COG4993	Dehydrogenase
IGS75_06005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IGS75_06010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IGS75_06025	COG0508	dehydrogenase complex catalyzes the overall conversion of
IGS75_06050	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IGS75_06065	COG3961	Belongs to the TPP enzyme family
IGS75_06075	COG1194	a g-specific adenine glycosylase
IGS75_06090	COG0560	Phosphoserine phosphatase
IGS75_06095	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IGS75_06100	COG0028	Belongs to the TPP enzyme family
IGS75_06105	COG0440	acetolactate synthase activity
IGS75_06110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IGS75_06115	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IGS75_06120	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IGS75_06140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IGS75_06145	COG0509	glycine decarboxylation via glycine cleavage system
IGS75_06150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IGS75_06150	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IGS75_06160	COG2608	mercury ion transmembrane transporter activity
IGS75_06170	COG0174	glutamine synthetase
IGS75_06185	COG0312	modulator of DNA gyrase
IGS75_06205	COG0438	transferase activity, transferring glycosyl groups
IGS75_06205	COG1216	Glycosyl transferase, family 2
IGS75_06215	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IGS75_06220	COG1215	transferase activity, transferring glycosyl groups
IGS75_06225	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IGS75_06230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IGS75_06235	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IGS75_06240	COG0356	it plays a direct role in the translocation of protons across the membrane
IGS75_06250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IGS75_06275	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IGS75_06285	COG5487	UPF0391 membrane protein
IGS75_06295	COG1012	belongs to the aldehyde dehydrogenase family
IGS75_06300	COG1215	transferase activity, transferring glycosyl groups
IGS75_06315	COG3754	Rhamnan synthesis protein F
IGS75_06320	COG0776	regulation of translation
IGS75_06355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS75_06360	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IGS75_06375	COG0753	catalase activity
IGS75_06380	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_06385	COG0477	Major facilitator Superfamily
IGS75_06390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IGS75_06395	COG0193	aminoacyl-tRNA hydrolase activity
IGS75_06400	COG0012	GTP binding
IGS75_06405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IGS75_06410	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IGS75_06415	COG0799	negative regulation of ribosome biogenesis
IGS75_06420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IGS75_06435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGS75_06485	COG0604	alcohol dehydrogenase
IGS75_06485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IGS75_06485	COG3321	synthase
IGS75_06485	COG4221	oxidoreductase activity
IGS75_06500	COG2188	Transcriptional regulator
IGS75_06505	COG1228	amidohydrolase
IGS75_06510	COG0402	S-adenosylhomocysteine deaminase activity
IGS75_06520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IGS75_06525	COG2986	histidine ammonia-lyase
IGS75_06540	COG0277	FAD linked oxidase domain protein
IGS75_06545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IGS75_06555	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IGS75_06565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS75_06580	COG1522	sequence-specific DNA binding
IGS75_06585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IGS75_06590	COG1959	2 iron, 2 sulfur cluster binding
IGS75_06600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IGS75_06615	COG0133	tryptophan synthase activity
IGS75_06620	COG0159	tryptophan synthase activity
IGS75_06630	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IGS75_06635	COG0285	dihydrofolate synthase activity
IGS75_06640	COG0305	Participates in initiation and elongation during chromosome replication
IGS75_06795	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IGS75_06800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IGS75_06805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IGS75_06810	COG2137	regulation of response to DNA damage stimulus
IGS75_06820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IGS75_06825	COG0235	Class ii aldolase
IGS75_06830	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IGS75_06835	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IGS75_06840	COG0196	riboflavin kinase activity
IGS75_06860	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IGS75_06865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IGS75_06875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IGS75_06880	COG0277	FAD linked oxidase domain protein
IGS75_06900	COG0187	DNA topoisomerase II activity
IGS75_06915	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IGS75_06915	COG2885	chlorophyll binding
IGS75_06925	COG0793	Belongs to the peptidase S41A family
IGS75_06930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IGS75_06935	COG0758	DNA mediated transformation
IGS75_06940	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IGS75_06945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IGS75_06950	COG0540	Belongs to the ATCase OTCase family
IGS75_06955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IGS75_06970	COG2333	competence protein COMEC
IGS75_06970	COG0658	competence protein
IGS75_06980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IGS75_06985	COG5265	(ABC) transporter
IGS75_06990	COG1228	amidohydrolase
IGS75_07025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IGS75_07030	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IGS75_07035	COG1420	regulation of RNA biosynthetic process
IGS75_07075	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IGS75_07095	COG1301	dicarboxylic acid transport
IGS75_07115	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IGS75_07125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IGS75_07135	COG2995	paraquat-inducible protein a
IGS75_07140	COG3008	intermembrane lipid transfer
IGS75_07155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IGS75_07175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IGS75_07180	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IGS75_07185	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IGS75_07190	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IGS75_07195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IGS75_07240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IGS75_07265	COG2207	Transcriptional regulator
IGS75_07270	COG0300	oxidoreductase activity
IGS75_07280	COG0363	glucosamine-6-phosphate deaminase activity
IGS75_07285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IGS75_07295	COG2971	BadF BadG BcrA BcrD
IGS75_07300	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
IGS75_07310	COG1349	DNA-binding transcription factor activity
IGS75_07335	COG0583	DNA-binding transcription factor activity
IGS75_07350	COG0583	DNA-binding transcription factor activity
IGS75_07380	COG0765	amino acid transport
IGS75_07385	COG0765	amino acid transport
IGS75_07395	COG1126	abc transporter atp-binding protein
IGS75_07400	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_07425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS75_07430	COG0601	transmembrane transport
IGS75_07435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS75_07440	COG0444	Belongs to the ABC transporter superfamily
IGS75_07450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS75_07455	COG0747	negative chemotaxis
IGS75_07460	COG4221	oxidoreductase activity
IGS75_07465	COG2271	Major facilitator Superfamily
IGS75_07515	COG2271	Major facilitator Superfamily
IGS75_07535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS75_07545	COG0656	L-ascorbic acid biosynthetic process
IGS75_07555	COG0583	DNA-binding transcription factor activity
IGS75_07565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IGS75_07590	COG0697	spore germination
IGS75_07595	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IGS75_07600	COG1984	allophanate hydrolase subunit 2
IGS75_07605	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IGS75_07610	COG4221	oxidoreductase activity
IGS75_07615	COG0511	ligase activity, forming carbon-carbon bonds
IGS75_07630	COG0436	Aminotransferase
IGS75_07660	COG1902	pentaerythritol trinitrate reductase activity
IGS75_07670	COG0047	phosphoribosylformylglycinamidine synthase activity
IGS75_07680	COG0583	DNA-binding transcription factor activity
IGS75_07695	COG1280	lysine exporter protein (LysE YggA)
IGS75_07700	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IGS75_07705	COG0473	3-isopropylmalate dehydrogenase activity
IGS75_07715	COG0628	permease
IGS75_07735	COG0840	transmembrane signaling receptor activity
IGS75_07765	COG0438	transferase activity, transferring glycosyl groups
IGS75_07775	COG0247	lactate metabolic process
IGS75_07780	COG1139	Iron-sulfur cluster binding protein
IGS75_07805	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IGS75_07810	COG2197	response regulator
IGS75_07815	COG4585	Histidine kinase
IGS75_07820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IGS75_07830	COG1131	(ABC) transporter
IGS75_07835	COG2945	thiolester hydrolase activity
IGS75_07845	COG1104	cysteine desulfurase activity
IGS75_07855	COG0482	sulfurtransferase activity
IGS75_07925	COG1609	Transcriptional regulator
IGS75_07955	COG4774	siderophore transport
IGS75_07960	COG3511	phospholipase C
IGS75_07970	COG1999	signal sequence binding
IGS75_08025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IGS75_08040	COG1335	isochorismatase
IGS75_08060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IGS75_08065	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IGS75_08115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IGS75_08125	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IGS75_08170	COG2983	Belongs to the UPF0260 family
IGS75_08205	COG1566	PFAM secretion protein HlyD family protein
IGS75_08230	COG0484	heat shock protein binding
IGS75_08240	COG3104	oligopeptide transport
IGS75_08275	COG0741	lytic transglycosylase activity
IGS75_08310	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IGS75_08330	COG0489	protein tyrosine kinase activity
IGS75_08345	COG0246	Mannitol dehydrogenase
IGS75_08355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IGS75_08370	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IGS75_08375	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IGS75_08395	COG0343	queuine tRNA-ribosyltransferase activity
IGS75_08400	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IGS75_08410	COG3956	TIGRFAM MazG family protein
IGS75_08415	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IGS75_08430	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IGS75_08435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IGS75_08450	COG0552	protein localization to endoplasmic reticulum
IGS75_08455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IGS75_08460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IGS75_08470	COG0513	Belongs to the DEAD box helicase family
IGS75_08480	COG2326	polyphosphate kinase activity
IGS75_08485	COG4221	oxidoreductase activity
IGS75_08490	COG1678	Uncharacterized ACR, COG1678
IGS75_08495	COG2999	glutathione oxidoreductase activity
IGS75_08505	COG0667	Aldo Keto reductase
IGS75_08510	COG0542	response to heat
IGS75_08560	COG0483	inositol monophosphate 1-phosphatase activity
IGS75_08580	COG2267	carboxylic ester hydrolase activity
IGS75_08615	COG0583	DNA-binding transcription factor activity
IGS75_08620	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IGS75_08630	COG1811	Na channel or pump
IGS75_08675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS75_08690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS75_08695	COG0765	amino acid transport
IGS75_08700	COG0765	amino acid transport
IGS75_08705	COG1126	abc transporter atp-binding protein
IGS75_08710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS75_08720	COG0765	amino acid transport
IGS75_08730	COG1126	abc transporter atp-binding protein
IGS75_08735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS75_08790	COG3511	phospholipase C
IGS75_08865	COG0745	RESPONSE REGULATOR receiver
IGS75_08890	COG1012	belongs to the aldehyde dehydrogenase family
IGS75_08895	COG4993	Dehydrogenase
IGS75_08895	COG2010	Cytochrome c
IGS75_08900	COG4771	TonB-dependent receptor
IGS75_08905	COG1960	acyl-CoA dehydrogenase activity
IGS75_08910	COG4638	Rieske (2fe-2S)
IGS75_08930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IGS75_08935	COG0235	Class ii aldolase
IGS75_09040	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IGS75_09040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IGS75_09045	COG1494	fructose-1,6-bisphosphatase
IGS75_09055	COG0436	Aminotransferase
IGS75_09065	COG0740	serine-type endopeptidase activity
IGS75_09075	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IGS75_09080	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IGS75_09085	COG1684	flagellar biosynthetic protein fliR
IGS75_09090	COG1987	bacterial-type flagellum assembly
IGS75_09095	COG1677	Flagellar hook-basal body complex protein FliE
IGS75_09100	COG1558	bacterial-type flagellum-dependent cell motility
IGS75_09105	COG1815	bacterial-type flagellum-dependent cell motility
IGS75_09120	COG1338	Plays a role in the flagellum-specific transport system
IGS75_09125	COG0405	Gamma-glutamyltransferase
IGS75_09135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IGS75_09140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IGS75_09145	COG0302	gtp cyclohydrolase
IGS75_09160	COG3588	fructose-bisphosphate aldolase
IGS75_09170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IGS75_09175	COG0602	queuosine metabolic process
IGS75_09205	COG0840	transmembrane signaling receptor activity
IGS75_09215	COG0745	RESPONSE REGULATOR receiver
IGS75_09220	COG0643	Histidine kinase
IGS75_09220	COG2198	Histidine kinase
IGS75_09225	COG0835	chemotaxis
IGS75_09230	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IGS75_09235	COG2201	protein-glutamate methylesterase activity
IGS75_09240	COG0745	RESPONSE REGULATOR receiver
IGS75_09250	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IGS75_09265	COG0741	lytic transglycosylase activity
IGS75_09275	COG1238	metal cluster binding
IGS75_09285	COG0793	Belongs to the peptidase S41A family
IGS75_09285	COG3409	Peptidoglycan-binding domain 1 protein
IGS75_09290	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IGS75_09295	COG4133	protoheme IX ABC transporter activity
IGS75_09300	COG1126	abc transporter atp-binding protein
IGS75_09305	COG0765	amino acid transport
IGS75_09315	COG0542	response to heat
IGS75_09325	COG0779	Required for maturation of 30S ribosomal subunits
IGS75_09340	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IGS75_09345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IGS75_09350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IGS75_09355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IGS75_09360	COG1185	polyribonucleotide nucleotidyltransferase activity
IGS75_09395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IGS75_09400	COG3158	transport of potassium into the cell
IGS75_09405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IGS75_09415	COG0667	Aldo Keto reductase
IGS75_09445	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IGS75_09475	COG3300	MHYT domain
IGS75_09475	COG5001	Diguanylate cyclase
IGS75_09485	COG0667	Aldo Keto reductase
IGS75_09495	COG0523	cobalamin synthesis protein
IGS75_09505	COG3920	Histidine kinase
IGS75_09505	COG2202	Pas domain
IGS75_09510	COG0784	Response regulator, receiver
IGS75_09510	COG4191	Histidine kinase
IGS75_09520	COG0671	phosphoesterase, PA-phosphatase related
IGS75_09530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IGS75_09540	COG0693	protein deglycase activity
IGS75_09545	COG2862	Uncharacterized protein family, UPF0114
IGS75_09550	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IGS75_09570	COG1741	Belongs to the pirin family
IGS75_09575	COG0156	8-amino-7-oxononanoate synthase activity
IGS75_09600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IGS75_09605	COG4251	negative regulation of phosphorylation
IGS75_09615	COG0114	fumarate hydratase activity
IGS75_09635	COG3088	subunit of a heme lyase
IGS75_09640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IGS75_09645	COG1138	Cytochrome C-type biogenesis protein
IGS75_09650	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IGS75_09660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IGS75_09685	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IGS75_09705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IGS75_09715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IGS75_09720	COG0564	pseudouridine synthase activity
IGS75_09740	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IGS75_09740	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IGS75_09770	COG1252	NADH dehydrogenase
IGS75_09775	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IGS75_09780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IGS75_09785	COG0653	protein targeting
IGS75_09790	COG0217	transcriptional regulatory protein
IGS75_09795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IGS75_09800	COG0632	four-way junction helicase activity
IGS75_09805	COG2255	four-way junction helicase activity
IGS75_09810	COG0824	Thioesterase
IGS75_09820	COG0848	biopolymer transport protein
IGS75_09830	COG0823	Involved in the tonB-independent uptake of proteins
IGS75_09835	COG2885	chlorophyll binding
IGS75_09845	COG0037	tRNA processing
IGS75_09850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IGS75_09855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGS75_09860	COG0745	RESPONSE REGULATOR receiver
IGS75_09885	COG2309	aminopeptidase activity
IGS75_09900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IGS75_09920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IGS75_09925	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IGS75_09930	COG0561	phosphatase activity
IGS75_09935	COG0363	glucosamine-6-phosphate deaminase activity
IGS75_09940	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IGS75_09945	COG3265	gluconokinase activity
IGS75_09950	COG1671	Belongs to the UPF0178 family
IGS75_09960	COG1012	belongs to the aldehyde dehydrogenase family
IGS75_09965	COG0584	glycerophosphoryl diester phosphodiesterase
IGS75_09985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IGS75_09990	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IGS75_10005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IGS75_10005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IGS75_10015	COG0747	negative chemotaxis
IGS75_10030	COG1570	exodeoxyribonuclease VII activity
IGS75_10040	COG1530	ribonuclease E activity
IGS75_10055	COG0730	response to heat
IGS75_10085	COG0768	penicillin binding
IGS75_10090	COG0772	Belongs to the SEDS family
IGS75_10105	COG0752	glycyl-tRNA synthetase alpha subunit
IGS75_10120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IGS75_10135	COG0708	Exodeoxyribonuclease III
IGS75_10140	COG0316	Belongs to the HesB IscA family
IGS75_10145	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IGS75_10150	COG0018	arginyl-trna synthetase
IGS75_10165	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IGS75_10170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IGS75_10175	COG0805	protein transport
IGS75_10180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IGS75_10185	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IGS75_10210	COG1289	transmembrane transporter activity
IGS75_10215	COG2267	carboxylic ester hydrolase activity
IGS75_10225	COG3145	DNA-N1-methyladenine dioxygenase activity
IGS75_10230	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IGS75_10245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IGS75_10260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IGS75_10265	COG0215	cysteine-tRNA ligase activity
IGS75_10275	COG2814	Major facilitator Superfamily
IGS75_10285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IGS75_10315	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IGS75_10325	COG2885	chlorophyll binding
IGS75_10325	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IGS75_10330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IGS75_10340	COG4974	Belongs to the 'phage' integrase family
IGS75_10345	COG0825	malonyl-CoA metabolic process
IGS75_10350	COG1058	Belongs to the CinA family
IGS75_10350	COG1546	Belongs to the CinA family
IGS75_10360	COG0494	nUDIX hydrolase
IGS75_10380	COG1862	Preprotein translocase
IGS75_10395	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IGS75_10400	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IGS75_10420	COG1758	RNA polymerase activity
IGS75_10430	COG0736	holo-[acyl-carrier-protein] synthase activity
IGS75_10435	COG0681	Belongs to the peptidase S26 family
IGS75_10445	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IGS75_10450	COG0528	UMP kinase activity
IGS75_10455	COG0233	cytoplasmic translational termination
IGS75_10460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IGS75_10470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IGS75_10475	COG0750	zinc metalloprotease
IGS75_10490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IGS75_10495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IGS75_10500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IGS75_10505	COG3494	Protein of unknown function (DUF1009)
IGS75_10510	COG0346	lactoylglutathione lyase activity
IGS75_10520	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IGS75_10525	COG0594	ribonuclease P activity
IGS75_10530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IGS75_10535	COG0706	membrane insertase activity
IGS75_10540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IGS75_10545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IGS75_10555	COG2171	N-acyltransferase activity
IGS75_10560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS75_10570	COG0101	tRNA pseudouridine synthase activity
IGS75_10575	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IGS75_10580	COG0242	peptide deformylase activity
IGS75_10595	COG0251	oxidation-reduction process
IGS75_10610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IGS75_10615	COG1137	ATPase activity
IGS75_10630	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IGS75_10630	COG0517	IMP dehydrogenase activity
IGS75_10660	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IGS75_10660	COG2755	lipolytic protein G-D-S-L family
IGS75_10665	COG1164	Oligoendopeptidase f
IGS75_10670	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IGS75_10685	COG0556	nucleotide-excision repair
IGS75_10695	COG0189	ligase activity
IGS75_10705	COG2226	methyltransferase
IGS75_10710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IGS75_10715	COG0109	protoheme IX farnesyltransferase activity
IGS75_10725	COG0312	modulator of DNA gyrase
IGS75_10730	COG0612	Peptidase, M16
IGS75_10745	COG0457	Tetratricopeptide repeat
IGS75_10750	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IGS75_10755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IGS75_10775	COG0386	Belongs to the glutathione peroxidase family
IGS75_10780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IGS75_10785	COG2032	superoxide dismutase activity
IGS75_10790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IGS75_10795	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IGS75_10800	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IGS75_10805	COG0181	hydroxymethylbilane synthase activity
IGS75_10815	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IGS75_10835	COG1858	cytochrome C peroxidase
IGS75_10865	COG0408	coproporphyrinogen oxidase activity
IGS75_10870	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IGS75_10880	COG4221	oxidoreductase activity
IGS75_10885	COG0412	Dienelactone hydrolase
IGS75_10895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IGS75_10900	COG0459	protein refolding
IGS75_10915	COG1199	ATP-dependent helicase activity
IGS75_10930	COG2095	MarC family integral membrane protein
IGS75_10935	COG1573	uracil-dna glycosylase
IGS75_10945	COG0670	Belongs to the BI1 family
IGS75_10965	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IGS75_10985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IGS75_11025	COG0488	(ABC) transporter
IGS75_11030	COG0105	UTP biosynthetic process
IGS75_11035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IGS75_11040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IGS75_11050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IGS75_11065	COG2814	Major facilitator Superfamily
IGS75_11080	COG0019	diaminopimelate decarboxylase activity
IGS75_11085	COG0295	cytidine deaminase activity
IGS75_11095	COG4191	Histidine kinase
IGS75_11095	COG0784	Response regulator, receiver
IGS75_11115	COG0519	Catalyzes the synthesis of GMP from XMP
IGS75_11115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IGS75_11140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IGS75_11145	COG0165	Argininosuccinate lyase
IGS75_11150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IGS75_11170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IGS75_11175	COG0237	dephospho-CoA kinase activity
IGS75_11180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IGS75_11190	COG0438	transferase activity, transferring glycosyl groups
IGS75_11225	COG1160	GTP binding
IGS75_11230	COG2814	Major facilitator Superfamily
IGS75_11235	COG2814	Major facilitator Superfamily
IGS75_11240	COG2264	protein methyltransferase activity
IGS75_11245	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IGS75_11255	COG3572	ergothioneine biosynthetic process
IGS75_11265	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IGS75_11270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IGS75_11290	COG1663	tetraacyldisaccharide 4'-kinase activity
IGS75_11295	COG1519	Transferase
IGS75_11310	COG0259	pyridoxamine-phosphate oxidase activity
IGS75_11320	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IGS75_11325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IGS75_11330	COG1764	response to oxidative stress
IGS75_11335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IGS75_11335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IGS75_11340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IGS75_11350	COG0142	geranyltranstransferase activity
IGS75_11355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IGS75_11360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IGS75_11380	COG0287	Prephenate dehydrogenase
IGS75_11380	COG1605	Chorismate mutase
IGS75_11385	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IGS75_11390	COG1196	nuclear chromosome segregation
IGS75_11395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IGS75_11400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IGS75_11410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IGS75_11415	COG1702	phosphate starvation-inducible protein PhoH
IGS75_11420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IGS75_11440	COG0859	PFAM glycosyl transferase family 9
IGS75_11440	COG0457	Tetratricopeptide repeat
IGS75_11450	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_11455	COG1329	Transcriptional regulator
IGS75_11460	COG3781	membrane
IGS75_11465	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IGS75_11470	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IGS75_11480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IGS75_11500	COG1136	(ABC) transporter
IGS75_11520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IGS75_11560	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IGS75_11570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS75_11575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGS75_11580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IGS75_11590	COG0483	inositol monophosphate 1-phosphatase activity
IGS75_11605	COG0438	transferase activity, transferring glycosyl groups
IGS75_11630	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IGS75_11645	COG0156	8-amino-7-oxononanoate synthase activity
IGS75_11650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS75_11655	COG0318	PFAM AMP-dependent synthetase and ligase
IGS75_11690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IGS75_11690	COG1648	precorrin-2 dehydrogenase activity
IGS75_11695	COG2066	Belongs to the glutaminase family
IGS75_11700	COG1914	H( )-stimulated, divalent metal cation uptake system
IGS75_11710	COG1349	DNA-binding transcription factor activity
IGS75_11715	COG0579	oxidoreductase
IGS75_11720	COG0277	FAD linked oxidase domain protein
IGS75_11735	COG1410	methionine synthase
IGS75_11735	COG0646	methionine synthase
IGS75_11775	COG1289	transmembrane transporter activity
IGS75_11820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IGS75_11860	COG0583	DNA-binding transcription factor activity
IGS75_11865	COG2249	NAD(P)H dehydrogenase (quinone) activity
IGS75_11870	COG1979	alcohol dehydrogenase
IGS75_11880	COG1012	belongs to the aldehyde dehydrogenase family
IGS75_11895	COG1566	PFAM secretion protein HlyD family protein
IGS75_11910	COG1289	transmembrane transporter activity
IGS75_11915	COG1802	Transcriptional regulator
IGS75_11920	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IGS75_11920	COG0506	proline dehydrogenase activity
IGS75_11920	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IGS75_11925	COG3191	aminopeptidase activity
IGS75_11930	COG4172	Belongs to the ABC transporter superfamily
IGS75_11935	COG0444	Belongs to the ABC transporter superfamily
IGS75_11940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS75_11945	COG0601	transmembrane transport
IGS75_11950	COG0747	negative chemotaxis
IGS75_11965	COG1127	ABC transporter
IGS75_11970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IGS75_11975	COG0463	Glycosyl transferase, family 2
IGS75_11980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IGS75_12005	COG0339	signal peptide processing
IGS75_12025	COG0583	DNA-binding transcription factor activity
IGS75_12030	COG3384	dioxygenase
IGS75_12035	COG2353	YceI-like domain
IGS75_12050	COG0488	(ABC) transporter
IGS75_12060	COG0038	chloride channel
IGS75_12110	COG4555	ABC transporter
IGS75_12115	COG1522	sequence-specific DNA binding
IGS75_12125	COG2855	membrane
IGS75_12135	COG1278	Cold shock
IGS75_12140	COG0306	phosphate transporter
IGS75_12155	COG3511	phospholipase C
IGS75_12175	COG4774	siderophore transport
IGS75_12180	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_12185	COG3842	ATPase activity
IGS75_12190	COG0395	ABC-type sugar transport system, permease component
IGS75_12205	COG1069	ribulokinase activity
IGS75_12210	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_12240	COG4172	Belongs to the ABC transporter superfamily
IGS75_12245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS75_12250	COG0601	transmembrane transport
IGS75_12255	COG0747	negative chemotaxis
IGS75_12275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS75_12290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGS75_12300	COG2207	Transcriptional regulator
IGS75_12310	COG4221	oxidoreductase activity
IGS75_12370	COG1472	Belongs to the glycosyl hydrolase 3 family
IGS75_12385	COG1846	Transcriptional regulator
IGS75_12390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IGS75_12395	COG2080	2 iron, 2 sulfur cluster binding
IGS75_12400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS75_12400	COG2010	Cytochrome c
IGS75_12405	COG2233	PERMEase
IGS75_12410	COG2309	aminopeptidase activity
IGS75_12415	COG1335	isochorismatase
IGS75_12420	COG0596	Alpha beta hydrolase
IGS75_12430	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IGS75_12445	COG2022	thiamine diphosphate biosynthetic process
IGS75_12455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IGS75_12520	COG4558	Periplasmic binding protein
IGS75_12525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS75_12530	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IGS75_12545	COG4774	siderophore transport
IGS75_12565	COG0583	DNA-binding transcription factor activity
IGS75_12600	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_12645	COG0135	phosphoribosylanthranilate isomerase activity
IGS75_12650	COG0284	orotidine-5'-phosphate decarboxylase activity
IGS75_12660	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IGS75_12675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IGS75_12680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IGS75_12700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IGS75_12715	COG0469	pyruvate kinase activity
IGS75_12720	COG0287	Prephenate dehydrogenase
IGS75_12730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS75_12735	COG1215	transferase activity, transferring glycosyl groups
IGS75_12740	COG1562	ergosterol biosynthetic process
IGS75_12745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IGS75_12755	COG1562	ergosterol biosynthetic process
IGS75_12760	COG1233	COG1233 Phytoene dehydrogenase and related
IGS75_12765	COG1657	PFAM Prenyltransferase squalene oxidase
IGS75_12775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGS75_12780	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IGS75_12800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IGS75_12800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IGS75_12820	COG0745	RESPONSE REGULATOR receiver
IGS75_12835	COG0322	excinuclease ABC activity
IGS75_12840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IGS75_12850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IGS75_12855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IGS75_12865	COG0148	phosphopyruvate hydratase activity
IGS75_12875	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IGS75_12880	COG0504	CTP synthase activity
IGS75_12890	COG0149	triose-phosphate isomerase activity
IGS75_12900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IGS75_12910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IGS75_12915	COG0134	indole-3-glycerol-phosphate synthase activity
IGS75_12920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IGS75_12925	COG0508	dehydrogenase complex catalyzes the overall conversion of
IGS75_12925	COG0022	dehydrogenase e1 component
IGS75_12930	COG0508	dehydrogenase complex catalyzes the overall conversion of
IGS75_12935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IGS75_12940	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IGS75_12945	COG2867	negative regulation of translational initiation
IGS75_12965	COG0861	Integral membrane protein TerC family
IGS75_12970	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IGS75_12975	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IGS75_12980	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IGS75_12990	COG0047	phosphoribosylformylglycinamidine synthase activity
IGS75_12995	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IGS75_13005	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IGS75_13020	COG0113	porphobilinogen synthase activity
IGS75_13025	COG0531	amino acid
IGS75_13030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IGS75_13045	COG0438	transferase activity, transferring glycosyl groups
IGS75_13050	COG0513	Belongs to the DEAD box helicase family
IGS75_13080	COG0346	lactoylglutathione lyase activity
IGS75_13090	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_13150	COG0582	viral genome integration into host DNA
IGS75_13160	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IGS75_13165	COG0154	amidase activity
IGS75_13170	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IGS75_13175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IGS75_13190	COG1247	-acetyltransferase
IGS75_13195	COG2264	protein methyltransferase activity
IGS75_13205	COG2003	Belongs to the UPF0758 family
IGS75_13210	COG2003	Belongs to the UPF0758 family
IGS75_13215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IGS75_13235	COG0071	Belongs to the small heat shock protein (HSP20) family
IGS75_13240	COG0254	rRNA binding
IGS75_13245	COG1970	mechanosensitive ion channel activity
IGS75_13260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IGS75_13270	COG0488	(ABC) transporter
IGS75_13275	COG0784	Response regulator, receiver
IGS75_13300	COG4988	ABC transporter
IGS75_13305	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IGS75_13325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IGS75_13330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IGS75_13335	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IGS75_13350	COG0837	glucose binding
IGS75_13370	COG0525	valine-tRNA ligase activity
IGS75_13380	COG0129	dihydroxy-acid dehydratase activity
IGS75_13390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGS75_13400	COG1116	anion transmembrane transporter activity
IGS75_13410	COG0756	dUTP diphosphatase activity
IGS75_13415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IGS75_13420	COG2226	methyltransferase
IGS75_13425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IGS75_13430	COG0268	Binds directly to 16S ribosomal RNA
IGS75_13460	COG1475	DNA binding
IGS75_13470	COG2337	Toxic component of a toxin-antitoxin (TA) module
IGS75_13550	COG0210	DNA helicase
IGS75_13580	COG3750	Belongs to the UPF0335 family
IGS75_13595	COG3437	response regulator, receiver
IGS75_13610	COG0629	single-stranded DNA binding
IGS75_13720	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IGS75_13745	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
IGS75_13760	COG3961	Belongs to the TPP enzyme family
IGS75_13765	COG0583	DNA-binding transcription factor activity
IGS75_13770	COG0583	DNA-binding transcription factor activity
IGS75_13775	COG0281	malic enzyme
IGS75_13780	COG0114	fumarate hydratase activity
IGS75_13835	COG1475	DNA binding
IGS75_13840	COG2161	toxin-antitoxin pair type II binding
IGS75_13850	COG0628	permease
IGS75_13860	COG3631	Ketosteroid isomerase-related protein
IGS75_13865	COG2814	Major facilitator Superfamily
IGS75_13870	COG1335	isochorismatase
IGS75_13930	COG3415	Transposase
IGS75_13980	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_14000	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IGS75_14020	COG0071	Belongs to the small heat shock protein (HSP20) family
IGS75_14065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS75_14080	COG5564	TIM-barrel signal transduction protein
IGS75_14085	COG0778	Nitroreductase
IGS75_14090	COG2814	Major facilitator Superfamily
IGS75_14100	COG0625	glutathione transferase activity
IGS75_14105	COG0583	DNA-binding transcription factor activity
IGS75_14115	COG3634	alkyl hydroperoxide reductase activity
IGS75_14120	COG2814	Major facilitator Superfamily
IGS75_14130	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_14140	COG0667	Aldo Keto reductase
IGS75_14205	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IGS75_14210	COG0523	cobalamin synthesis protein
IGS75_14215	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IGS75_14220	COG0302	gtp cyclohydrolase
IGS75_14235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IGS75_14245	COG0521	Mo-molybdopterin cofactor biosynthetic process
IGS75_14310	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_14330	COG1408	metallophosphoesterase
IGS75_14360	COG1192	Involved in chromosome partitioning
IGS75_14365	COG1475	DNA binding
IGS75_14495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IGS75_14545	COG1902	pentaerythritol trinitrate reductase activity
IGS75_14555	COG0300	oxidoreductase activity
IGS75_14560	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_14570	COG0300	oxidoreductase activity
IGS75_14575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGS75_14585	COG3550	peptidyl-serine autophosphorylation
IGS75_14600	COG1802	Transcriptional regulator
IGS75_14625	COG2801	Transposase and inactivated derivatives
IGS75_14630	COG1733	regulation of RNA biosynthetic process
IGS75_14670	COG0300	oxidoreductase activity
IGS75_14685	COG4221	oxidoreductase activity
IGS75_14725	COG3631	Ketosteroid isomerase-related protein
IGS75_14730	COG0477	Major facilitator Superfamily
IGS75_14735	COG1335	isochorismatase
IGS75_14740	COG1309	transcriptional regulator
IGS75_14750	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IGS75_14755	COG0583	DNA-binding transcription factor activity
IGS75_14765	COG0587	DNA-directed DNA polymerase activity
IGS75_14830	COG2161	toxin-antitoxin pair type II binding
IGS75_14835	COG1475	DNA binding
IGS75_14865	COG0629	single-stranded DNA binding
IGS75_14895	COG4957	zinc ion binding
IGS75_14925	COG1028	Short-chain dehydrogenase reductase Sdr
IGS75_14930	COG0583	DNA-binding transcription factor activity
IGS75_14970	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IGS75_14975	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IGS75_14975	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IGS75_14980	COG2942	2-epimerase
IGS75_15005	COG1476	TRANSCRIPTIONal
IGS75_15025	COG2176	DNA-directed DNA polymerase activity
IGS75_15040	COG1192	Involved in chromosome partitioning
IGS75_15220	COG1192	Involved in chromosome partitioning
IGS75_15275	COG2337	Toxic component of a toxin-antitoxin (TA) module
IGS75_15280	COG4974	Belongs to the 'phage' integrase family