locus-tag	class	description
FXF46_00040	COG0583	DNA-binding transcription factor activity
FXF46_00050	COG0776	regulation of translation
FXF46_00055	COG0616	signal peptide processing
FXF46_00060	COG4957	zinc ion binding
FXF46_00065	COG1573	uracil-dna glycosylase
FXF46_00070	COG1289	transmembrane transporter activity
FXF46_00095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FXF46_00100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FXF46_00105	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FXF46_00110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FXF46_00120	COG3750	Belongs to the UPF0335 family
FXF46_00125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FXF46_00145	COG2001	Belongs to the MraZ family
FXF46_00150	COG0275	rRNA processing
FXF46_00165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FXF46_00170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FXF46_00175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FXF46_00180	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FXF46_00190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FXF46_00195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FXF46_00200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FXF46_00205	COG1181	Belongs to the D-alanine--D-alanine ligase family
FXF46_00210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FXF46_00215	COG0849	cell division
FXF46_00225	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FXF46_00230	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FXF46_00235	COG0497	DNA recombination
FXF46_00240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FXF46_00245	COG1253	flavin adenine dinucleotide binding
FXF46_00250	COG1335	isochorismatase
FXF46_00275	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FXF46_00290	COG0328	RNA-DNA hybrid ribonuclease activity
FXF46_00295	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FXF46_00300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FXF46_00315	COG1297	OPT oligopeptide transporter protein
FXF46_00325	COG2096	Adenosyltransferase
FXF46_00365	COG0473	3-isopropylmalate dehydrogenase activity
FXF46_00370	COG0066	3-isopropylmalate dehydratase activity
FXF46_00375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FXF46_00380	COG0335	large ribosomal subunit rRNA binding
FXF46_00385	COG0336	Belongs to the RNA methyltransferase TrmD family
FXF46_00390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FXF46_00395	COG0228	four-way junction DNA binding
FXF46_00400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FXF46_00425	COG2336	PFAM SpoVT AbrB
FXF46_00430	COG2337	Toxic component of a toxin-antitoxin (TA) module
FXF46_00505	COG0513	Belongs to the DEAD box helicase family
FXF46_00515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FXF46_00515	COG2813	Specifically methylates the guanine in position
FXF46_00520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FXF46_00540	COG3676	manually curated
FXF46_00545	COG3706	GGDEF domain
FXF46_00585	COG1408	metallophosphoesterase
FXF46_00595	COG1309	transcriptional regulator
FXF46_00610	COG1733	regulation of RNA biosynthetic process
FXF46_00620	COG0583	DNA-binding transcription factor activity
FXF46_00625	COG0583	DNA-binding transcription factor activity
FXF46_00645	COG1335	isochorismatase
FXF46_00650	COG0477	Major facilitator Superfamily
FXF46_00715	COG1692	metallophosphoesterase
FXF46_00720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FXF46_00745	COG0352	thiamine-phosphate diphosphorylase activity
FXF46_00775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FXF46_00780	COG0483	inositol monophosphate 1-phosphatase activity
FXF46_00800	COG0481	GTPase activity
FXF46_00820	COG2252	PERMEase
FXF46_00845	COG1722	exodeoxyribonuclease VII activity
FXF46_00850	COG0142	geranyltranstransferase activity
FXF46_00855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FXF46_00860	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FXF46_00865	COG1309	transcriptional regulator
FXF46_00875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FXF46_00880	COG0137	argininosuccinate synthase activity
FXF46_00885	COG0545	Peptidyl-prolyl cis-trans isomerase
FXF46_00905	COG0180	Tryptophanyl-tRNA synthetase
FXF46_00910	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FXF46_00915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FXF46_00915	COG0072	phenylalanine-tRNA ligase activity
FXF46_00920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FXF46_00925	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FXF46_00930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FXF46_00935	COG4993	Dehydrogenase
FXF46_00955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FXF46_00960	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FXF46_00970	COG4191	Histidine kinase
FXF46_00985	COG2884	Cell division ATP-binding protein ftsE
FXF46_01010	COG1271	oxidase subunit
FXF46_01015	COG1294	oxidase, subunit
FXF46_01025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXF46_01035	COG0688	phosphatidylethanolamine metabolic process
FXF46_01040	COG1183	phosphatidylcholine synthase activity
FXF46_01045	COG1940	carbohydrate kinase activity
FXF46_01050	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXF46_01055	COG0649	NAD binding
FXF46_01055	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXF46_01055	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXF46_01080	COG0656	L-ascorbic acid biosynthetic process
FXF46_01090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FXF46_01105	COG0009	L-threonylcarbamoyladenylate synthase
FXF46_01125	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FXF46_01130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXF46_01135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FXF46_01140	COG2818	Glycosylase
FXF46_01145	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FXF46_01150	COG0359	binds to the 23S rRNA
FXF46_01155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FXF46_01160	COG0360	Binds together with S18 to 16S ribosomal RNA
FXF46_01170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FXF46_01175	COG0358	DNA primase activity
FXF46_01185	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FXF46_01190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FXF46_01195	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FXF46_01215	COG0840	transmembrane signaling receptor activity
FXF46_01225	COG0505	Belongs to the CarA family
FXF46_01230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FXF46_01235	COG3655	Transcriptional regulator
FXF46_01245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXF46_01250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FXF46_01265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FXF46_01270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FXF46_01280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FXF46_01290	COG0793	Belongs to the peptidase S41A family
FXF46_01300	COG0494	nUDIX hydrolase
FXF46_01305	COG1132	(ABC) transporter
FXF46_01310	COG0617	tRNA 3'-terminal CCA addition
FXF46_01320	COG0714	Associated with various cellular activities
FXF46_01345	COG0596	Alpha beta hydrolase
FXF46_01355	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FXF46_01360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FXF46_01380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FXF46_01390	COG1538	Outer membrane efflux protein
FXF46_01405	COG2814	Major facilitator Superfamily
FXF46_01410	COG0203	ribosomal protein L17
FXF46_01415	COG0202	RNA polymerase activity
FXF46_01420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FXF46_01425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FXF46_01430	COG0563	adenylate kinase activity
FXF46_01440	COG0200	Binds to the 23S rRNA
FXF46_01445	COG1841	ribosomal large subunit assembly
FXF46_01450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FXF46_01455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FXF46_01460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FXF46_01465	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FXF46_01470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FXF46_01475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FXF46_01480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FXF46_01485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FXF46_01490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FXF46_01495	COG0255	Belongs to the universal ribosomal protein uL29 family
FXF46_01500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FXF46_01505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FXF46_01510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FXF46_01515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FXF46_01520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FXF46_01525	COG0089	rRNA binding
FXF46_01530	COG0088	Forms part of the polypeptide exit tunnel
FXF46_01535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FXF46_01540	COG0051	transcription antitermination factor activity, RNA binding
FXF46_01545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FXF46_01550	COG0049	tRNA binding
FXF46_01555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FXF46_01560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FXF46_01565	COG0085	RNA polymerase activity
FXF46_01570	COG0222	ribosome binding
FXF46_01575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FXF46_01580	COG0081	regulation of translation
FXF46_01585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FXF46_01590	COG1538	Outer membrane efflux protein
FXF46_01605	COG2205	protein histidine kinase activity
FXF46_01610	COG0745	RESPONSE REGULATOR receiver
FXF46_01625	COG2081	HI0933 family
FXF46_01635	COG0850	regulation of cytokinetic process
FXF46_01640	COG2894	cell division
FXF46_01645	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FXF46_01660	COG4771	TonB-dependent receptor
FXF46_01665	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_01680	COG0495	leucyl-tRNA aminoacylation
FXF46_01700	COG0679	Auxin Efflux Carrier
FXF46_01705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FXF46_01710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXF46_01720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FXF46_01725	COG0455	bacterial-type flagellum organization
FXF46_01730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FXF46_01735	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FXF46_01740	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FXF46_01750	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FXF46_01755	COG1766	The M ring may be actively involved in energy transduction
FXF46_01775	COG0138	bifunctional purine biosynthesis protein purh
FXF46_01785	COG0800	Aldolase
FXF46_01790	COG0129	dihydroxy-acid dehydratase activity
FXF46_01825	COG0439	Biotin carboxylase
FXF46_01830	COG0511	ligase activity, forming carbon-carbon bonds
FXF46_01835	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FXF46_01845	COG1295	ribonuclease BN
FXF46_01855	COG3585	molybdate ion transport
FXF46_01870	COG0314	molybdopterin synthase activity
FXF46_01875	COG0315	cyclic pyranopterin monophosphate synthase activity
FXF46_01875	COG0746	molybdenum cofactor guanylyltransferase activity
FXF46_01885	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FXF46_01890	COG0303	'Molybdopterin
FXF46_01895	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FXF46_01905	COG0662	Cupin 2, conserved barrel domain protein
FXF46_01905	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FXF46_01915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FXF46_01920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FXF46_01925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FXF46_01940	COG0697	spore germination
FXF46_01955	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_01960	COG0659	secondary active sulfate transmembrane transporter activity
FXF46_01980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FXF46_01985	COG1923	regulation of RNA biosynthetic process
FXF46_01990	COG2204	response regulator
FXF46_02010	COG2267	carboxylic ester hydrolase activity
FXF46_02020	COG0167	dihydroorotate dehydrogenase activity
FXF46_02030	COG3264	Mechanosensitive ion channel
FXF46_02030	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FXF46_02045	COG0604	alcohol dehydrogenase
FXF46_02050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FXF46_02055	COG0778	Nitroreductase
FXF46_02060	COG0131	Imidazoleglycerol-phosphate dehydratase
FXF46_02070	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FXF46_02075	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FXF46_02080	COG0107	imidazoleglycerol-phosphate synthase activity
FXF46_02085	COG0140	phosphoribosyl-ATP diphosphatase activity
FXF46_02110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FXF46_02175	COG4774	siderophore transport
FXF46_02180	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXF46_02185	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXF46_02190	COG0649	NAD binding
FXF46_02190	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXF46_02205	COG1034	ATP synthesis coupled electron transport
FXF46_02210	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FXF46_02215	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXF46_02225	COG0713	ATP synthesis coupled electron transport
FXF46_02230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FXF46_02240	COG1007	ATP synthesis coupled electron transport
FXF46_02260	COG1657	PFAM Prenyltransferase squalene oxidase
FXF46_02270	COG3961	Belongs to the TPP enzyme family
FXF46_02275	COG0583	DNA-binding transcription factor activity
FXF46_02280	COG4774	siderophore transport
FXF46_02300	COG0038	chloride channel
FXF46_02340	COG0473	3-isopropylmalate dehydrogenase activity
FXF46_02345	COG1473	amidohydrolase
FXF46_02350	COG1012	belongs to the aldehyde dehydrogenase family
FXF46_02355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FXF46_02360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXF46_02375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXF46_02405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FXF46_02415	COG1522	sequence-specific DNA binding
FXF46_02420	COG1012	belongs to the aldehyde dehydrogenase family
FXF46_02430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FXF46_02510	COG0477	Major facilitator Superfamily
FXF46_02510	COG2814	Major facilitator Superfamily
FXF46_02515	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
FXF46_02520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXF46_02530	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXF46_02535	COG1129	ABC transporter
FXF46_02540	COG1879	ABC-type sugar transport system periplasmic component
FXF46_02565	COG0596	Alpha beta hydrolase
FXF46_02570	COG1335	isochorismatase
FXF46_02575	COG2309	aminopeptidase activity
FXF46_02580	COG2233	PERMEase
FXF46_02585	COG2010	Cytochrome c
FXF46_02585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FXF46_02590	COG2080	2 iron, 2 sulfur cluster binding
FXF46_02595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FXF46_02600	COG1846	Transcriptional regulator
FXF46_02655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FXF46_02660	COG1126	abc transporter atp-binding protein
FXF46_02670	COG0765	amino acid transport
FXF46_02680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXF46_02685	COG1126	abc transporter atp-binding protein
FXF46_02690	COG0765	amino acid transport
FXF46_02695	COG0765	amino acid transport
FXF46_02715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXF46_02810	COG0542	response to heat
FXF46_02815	COG0667	Aldo Keto reductase
FXF46_02825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FXF46_02830	COG2999	glutathione oxidoreductase activity
FXF46_02835	COG1678	Uncharacterized ACR, COG1678
FXF46_02840	COG4221	oxidoreductase activity
FXF46_02845	COG2326	polyphosphate kinase activity
FXF46_02850	COG0513	Belongs to the DEAD box helicase family
FXF46_02860	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FXF46_02865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FXF46_02870	COG0552	protein localization to endoplasmic reticulum
FXF46_02885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FXF46_02890	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FXF46_02905	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FXF46_02910	COG3956	TIGRFAM MazG family protein
FXF46_02930	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FXF46_02935	COG0343	queuine tRNA-ribosyltransferase activity
FXF46_02945	COG1285	pathogenesis
FXF46_02955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FXF46_02960	COG0384	phenazine biosynthesis protein PhzF
FXF46_02965	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FXF46_02980	COG0484	heat shock protein binding
FXF46_02985	COG0246	Mannitol dehydrogenase
FXF46_02995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FXF46_03000	COG0489	protein tyrosine kinase activity
FXF46_03015	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
FXF46_03085	COG3104	oligopeptide transport
FXF46_03090	COG0484	heat shock protein binding
FXF46_03100	COG1538	Outer membrane efflux protein
FXF46_03105	COG1566	PFAM secretion protein HlyD family protein
FXF46_03140	COG2983	Belongs to the UPF0260 family
FXF46_03165	COG3896	Chloramphenicol phosphotransferase-like protein
FXF46_03205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FXF46_03245	COG3177	Filamentation induced by cAMP protein fic
FXF46_03255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FXF46_03305	COG2169	Transcriptional regulator
FXF46_03305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FXF46_03325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FXF46_03335	COG1902	pentaerythritol trinitrate reductase activity
FXF46_03340	COG0640	Transcriptional regulator
FXF46_03355	COG0564	pseudouridine synthase activity
FXF46_03360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FXF46_03380	COG1476	TRANSCRIPTIONal
FXF46_03385	COG0126	phosphoglycerate kinase activity
FXF46_03415	COG1113	amino acid transport
FXF46_03420	COG1522	sequence-specific DNA binding
FXF46_03450	COG1393	Belongs to the ArsC family
FXF46_03455	COG0584	glycerophosphoryl diester phosphodiesterase
FXF46_03460	COG3142	Participates in the control of copper homeostasis
FXF46_03490	COG2814	Major facilitator Superfamily
FXF46_03495	COG2032	superoxide dismutase activity
FXF46_03505	COG2308	Evidence 4 Homologs of previously reported genes of
FXF46_03520	COG0583	DNA-binding transcription factor activity
FXF46_03525	COG0473	3-isopropylmalate dehydrogenase activity
FXF46_03530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FXF46_03545	COG1280	lysine exporter protein (LysE YggA)
FXF46_03555	COG0450	alkyl hydroperoxide reductase
FXF46_03560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FXF46_03565	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_03570	COG0583	DNA-binding transcription factor activity
FXF46_03605	COG0482	sulfurtransferase activity
FXF46_03620	COG1104	cysteine desulfurase activity
FXF46_03625	COG2945	thiolester hydrolase activity
FXF46_03630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FXF46_03655	COG4771	TonB-dependent receptor
FXF46_03665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FXF46_03675	COG4585	Histidine kinase
FXF46_03680	COG2197	response regulator
FXF46_03690	COG0438	transferase activity, transferring glycosyl groups
FXF46_03745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FXF46_03755	COG1538	Outer membrane efflux protein
FXF46_03765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXF46_03815	COG0745	RESPONSE REGULATOR receiver
FXF46_03820	COG0704	Plays a role in the regulation of phosphate uptake
FXF46_03825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FXF46_03830	COG0581	inorganic phosphate transmembrane transporter activity
FXF46_03840	COG0438	transferase activity, transferring glycosyl groups
FXF46_03840	COG1216	Glycosyl transferase, family 2
FXF46_03845	COG0783	Belongs to the Dps family
FXF46_03870	COG1216	Glycosyl transferase, family 2
FXF46_03890	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FXF46_03905	COG0156	8-amino-7-oxononanoate synthase activity
FXF46_03920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FXF46_03920	COG4106	trans-aconitate 2-methyltransferase activity
FXF46_03925	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FXF46_03930	COG2943	transferase activity, transferring hexosyl groups
FXF46_03935	COG1733	regulation of RNA biosynthetic process
FXF46_03940	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
FXF46_03990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FXF46_04015	COG4974	Belongs to the 'phage' integrase family
FXF46_04030	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_04045	COG0004	ammonium transporteR
FXF46_04050	COG0347	Belongs to the P(II) protein family
FXF46_04060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FXF46_04065	COG1045	serine acetyltransferase
FXF46_04100	COG0488	(ABC) transporter
FXF46_04110	COG1289	transmembrane transporter activity
FXF46_04120	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FXF46_04160	COG2835	tetraacyldisaccharide 4'-kinase activity
FXF46_04165	COG0840	transmembrane signaling receptor activity
FXF46_04180	COG1396	sequence-specific DNA binding
FXF46_04185	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FXF46_04200	COG4957	zinc ion binding
FXF46_04220	COG0778	Nitroreductase
FXF46_04230	COG2205	protein histidine kinase activity
FXF46_04235	COG0745	RESPONSE REGULATOR receiver
FXF46_04240	COG0191	fructose-bisphosphate aldolase activity
FXF46_04255	COG2814	Major facilitator Superfamily
FXF46_04260	COG1566	PFAM secretion protein HlyD family protein
FXF46_04265	COG1573	uracil-dna glycosylase
FXF46_04275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FXF46_04295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FXF46_04310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FXF46_04320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FXF46_04325	COG0590	tRNA wobble adenosine to inosine editing
FXF46_04325	COG0037	tRNA processing
FXF46_04330	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FXF46_04335	COG1187	pseudouridine synthase activity
FXF46_04340	COG0742	ribosomal rna small subunit methyltransferase
FXF46_04345	COG1674	ftsk spoiiie
FXF46_04350	COG0564	pseudouridine synthase activity
FXF46_04370	COG2814	Major facilitator Superfamily
FXF46_04385	COG0735	belongs to the Fur family
FXF46_04395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXF46_04400	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXF46_04405	COG1660	Displays ATPase and GTPase activities
FXF46_04410	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FXF46_04425	COG0642	Histidine kinase
FXF46_04430	COG0745	RESPONSE REGULATOR receiver
FXF46_04435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FXF46_04440	COG0859	PFAM glycosyl transferase family 9
FXF46_04450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FXF46_04455	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FXF46_04490	COG2205	protein histidine kinase activity
FXF46_04495	COG0745	RESPONSE REGULATOR receiver
FXF46_04505	COG2259	Doxx family
FXF46_04515	COG1643	Atp-dependent helicase
FXF46_04520	COG0778	Nitroreductase
FXF46_04525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FXF46_04535	COG2814	Major facilitator Superfamily
FXF46_04545	COG1695	Transcriptional regulator
FXF46_04565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FXF46_04575	COG2814	Major facilitator Superfamily
FXF46_04585	COG1956	GAF domain-containing protein
FXF46_04590	COG0625	glutathione transferase activity
FXF46_04595	COG0246	Mannitol dehydrogenase
FXF46_04610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FXF46_04615	COG0717	Belongs to the dCTP deaminase family
FXF46_04650	COG0443	Heat shock 70 kDa protein
FXF46_04655	COG0484	heat shock protein binding
FXF46_04665	COG1304	FMN binding
FXF46_04670	COG0406	alpha-ribazole phosphatase activity
FXF46_04670	COG0328	RNA-DNA hybrid ribonuclease activity
FXF46_04675	COG3588	fructose-bisphosphate aldolase
FXF46_04685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FXF46_04685	COG1017	nitric oxide dioxygenase activity
FXF46_04690	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FXF46_04695	COG1733	regulation of RNA biosynthetic process
FXF46_04700	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FXF46_04710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FXF46_04715	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FXF46_04725	COG2086	electron transfer activity
FXF46_04735	COG0681	Belongs to the peptidase S26 family
FXF46_04755	COG1621	beta-fructofuranosidase activity
FXF46_04770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FXF46_04785	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FXF46_04790	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FXF46_04795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FXF46_04825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FXF46_04840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FXF46_04845	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FXF46_04850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FXF46_04855	COG2226	methyltransferase
FXF46_04865	COG0454	-acetyltransferase
FXF46_04875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FXF46_04900	COG0402	S-adenosylhomocysteine deaminase activity
FXF46_04905	COG2233	PERMEase
FXF46_04910	COG2351	hydroxyisourate hydrolase activity
FXF46_04925	COG2072	flavoprotein involved in K transport
FXF46_04950	COG1733	regulation of RNA biosynthetic process
FXF46_04955	COG0668	transmembrane transport
FXF46_04980	COG2814	Major facilitator Superfamily
FXF46_04985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FXF46_05005	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FXF46_05010	COG2814	Major facilitator Superfamily
FXF46_05020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXF46_05030	COG0175	sulfate reduction
FXF46_05035	COG0175	sulfate reduction
FXF46_05040	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FXF46_05045	COG1842	Phage shock protein A
FXF46_05065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FXF46_05070	COG1127	ABC transporter
FXF46_05125	COG0446	pyridine nucleotide-disulphide oxidoreductase
FXF46_05145	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_05150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FXF46_05160	COG4786	Flagellar basal body rod
FXF46_05165	COG4786	Flagellar basal body rod
FXF46_05185	COG0596	Alpha beta hydrolase
FXF46_05190	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FXF46_05215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FXF46_05220	COG0588	phosphoglycerate mutase activity
FXF46_05235	COG3300	MHYT domain
FXF46_05235	COG5001	Diguanylate cyclase
FXF46_05270	COG3047	cAMP biosynthetic process
FXF46_05275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FXF46_05285	COG0415	Belongs to the DNA photolyase family
FXF46_05295	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FXF46_05295	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FXF46_05300	COG0307	riboflavin synthase, alpha
FXF46_05305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FXF46_05305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FXF46_05310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FXF46_05330	COG0535	radical SAM domain protein
FXF46_05340	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FXF46_05345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FXF46_05360	COG0194	GDP metabolic process
FXF46_05370	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_05375	COG0583	DNA-binding transcription factor activity
FXF46_05380	COG0330	HflC and HflK could
FXF46_05390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FXF46_05395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FXF46_05400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FXF46_05405	COG0424	maF-like protein
FXF46_05415	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FXF46_05430	COG1621	beta-fructofuranosidase activity
FXF46_05475	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FXF46_05475	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FXF46_05480	COG0326	Molecular chaperone. Has ATPase activity
FXF46_05495	COG1749	Flagellar hook protein flgE
FXF46_05505	COG0667	Aldo Keto reductase
FXF46_05530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FXF46_05545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FXF46_05550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FXF46_05555	COG0424	maF-like protein
FXF46_05590	COG1121	(ABC) transporter
FXF46_05605	COG2814	Major facilitator Superfamily
FXF46_05620	COG1091	dTDP-4-dehydrorhamnose reductase activity
FXF46_05625	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FXF46_05710	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FXF46_05725	COG1475	DNA binding
FXF46_05730	COG1192	Involved in chromosome partitioning
FXF46_05735	COG0357	Ribosomal RNA small subunit methyltransferase G
FXF46_05740	COG0445	tRNA wobble uridine modification
FXF46_05745	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FXF46_05750	COG2010	Cytochrome c
FXF46_05755	COG2010	Cytochrome c
FXF46_05755	COG4993	Dehydrogenase
FXF46_05760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FXF46_05765	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FXF46_05780	COG0508	dehydrogenase complex catalyzes the overall conversion of
FXF46_05805	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FXF46_05840	COG0673	inositol 2-dehydrogenase activity
FXF46_05850	COG1194	a g-specific adenine glycosylase
FXF46_05865	COG0560	Phosphoserine phosphatase
FXF46_05870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FXF46_05875	COG0028	Belongs to the TPP enzyme family
FXF46_05885	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FXF46_05895	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FXF46_05920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FXF46_05930	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FXF46_05930	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FXF46_05950	COG5212	phosphodiesterase
FXF46_05960	COG0174	glutamine synthetase
FXF46_05970	COG0436	Aminotransferase
FXF46_05975	COG0312	modulator of DNA gyrase
FXF46_06010	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FXF46_06015	COG0463	Glycosyl transferase, family 2
FXF46_06020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FXF46_06025	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FXF46_06030	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FXF46_06035	COG0356	it plays a direct role in the translocation of protons across the membrane
FXF46_06045	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXF46_06070	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FXF46_06080	COG5487	UPF0391 membrane protein
FXF46_06090	COG1012	belongs to the aldehyde dehydrogenase family
FXF46_06095	COG1215	transferase activity, transferring glycosyl groups
FXF46_06140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXF46_06145	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FXF46_06155	COG0402	S-adenosylhomocysteine deaminase activity
FXF46_06160	COG0753	catalase activity
FXF46_06165	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_06175	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FXF46_06180	COG0193	aminoacyl-tRNA hydrolase activity
FXF46_06200	COG0012	GTP binding
FXF46_06205	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FXF46_06210	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FXF46_06215	COG0799	negative regulation of ribosome biogenesis
FXF46_06220	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FXF46_06235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXF46_06300	COG1522	sequence-specific DNA binding
FXF46_06305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FXF46_06310	COG1959	2 iron, 2 sulfur cluster binding
FXF46_06320	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FXF46_06330	COG0598	Magnesium transport protein CorA
FXF46_06335	COG0133	tryptophan synthase activity
FXF46_06340	COG0159	tryptophan synthase activity
FXF46_06350	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FXF46_06355	COG0285	dihydrofolate synthase activity
FXF46_06365	COG0305	Participates in initiation and elongation during chromosome replication
FXF46_06520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FXF46_06525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FXF46_06530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FXF46_06535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FXF46_06540	COG2137	regulation of response to DNA damage stimulus
FXF46_06550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FXF46_06555	COG0235	Class ii aldolase
FXF46_06560	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FXF46_06565	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FXF46_06570	COG0196	riboflavin kinase activity
FXF46_06595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FXF46_06600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FXF46_06615	COG0277	FAD linked oxidase domain protein
FXF46_06620	COG1063	alcohol dehydrogenase
FXF46_06630	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_06635	COG1879	ABC-type sugar transport system periplasmic component
FXF46_06640	COG1129	ABC transporter
FXF46_06645	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXF46_06660	COG0187	DNA topoisomerase II activity
FXF46_06675	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FXF46_06675	COG2885	chlorophyll binding
FXF46_06685	COG0793	Belongs to the peptidase S41A family
FXF46_06690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FXF46_06695	COG0758	DNA mediated transformation
FXF46_06700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FXF46_06705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FXF46_06710	COG0540	Belongs to the ATCase OTCase family
FXF46_06715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FXF46_06735	COG2333	competence protein COMEC
FXF46_06735	COG0658	competence protein
FXF46_06740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FXF46_06745	COG5265	(ABC) transporter
FXF46_06760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FXF46_06765	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FXF46_06770	COG1420	regulation of RNA biosynthetic process
FXF46_06775	COG0667	Aldo Keto reductase
FXF46_06780	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FXF46_06815	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FXF46_06825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXF46_06830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FXF46_06835	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FXF46_06845	COG0363	glucosamine-6-phosphate deaminase activity
FXF46_06865	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
FXF46_06880	COG1349	DNA-binding transcription factor activity
FXF46_06915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FXF46_06930	COG2995	paraquat-inducible protein a
FXF46_06935	COG3008	intermembrane lipid transfer
FXF46_06950	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FXF46_06965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FXF46_06970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FXF46_06975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FXF46_06980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FXF46_06985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FXF46_07080	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FXF46_07080	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FXF46_07080	COG0506	proline dehydrogenase activity
FXF46_07090	COG0006	proline dipeptidase activity
FXF46_07095	COG0477	Major facilitator Superfamily
FXF46_07120	COG1937	Protein conserved in bacteria
FXF46_07135	COG2132	Multicopper oxidase
FXF46_07145	COG2217	Heavy metal translocating P-type atpase
FXF46_07155	COG4178	(ABC) transporter
FXF46_07170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FXF46_07195	COG0444	Belongs to the ABC transporter superfamily
FXF46_07200	COG4608	Belongs to the ABC transporter superfamily
FXF46_07210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FXF46_07225	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FXF46_07240	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FXF46_07245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FXF46_07250	COG0297	glycogen (starch) synthase activity
FXF46_07265	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_07270	COG0784	Response regulator, receiver
FXF46_07270	COG4191	Histidine kinase
FXF46_07305	COG2746	aminoglycoside 3-N-acetyltransferase activity
FXF46_07310	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FXF46_07325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXF46_07330	COG0492	ferredoxin-NADP+ reductase activity
FXF46_07345	COG0802	atpase or kinase
FXF46_07365	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FXF46_07380	COG1538	Outer membrane efflux protein
FXF46_07405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXF46_07440	COG1253	flavin adenine dinucleotide binding
FXF46_07455	COG1706	bacterial-type flagellum-dependent cell motility
FXF46_07460	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FXF46_07470	COG2801	Transposase and inactivated derivatives
FXF46_07510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FXF46_07540	COG1309	transcriptional regulator
FXF46_07545	COG1012	belongs to the aldehyde dehydrogenase family
FXF46_07565	COG1960	acyl-CoA dehydrogenase activity
FXF46_07570	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_07600	COG2814	Major facilitator Superfamily
FXF46_07630	COG0024	Methionine aminopeptidase
FXF46_07645	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FXF46_07650	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FXF46_07655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FXF46_07660	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_07665	COG3161	chorismate lyase activity
FXF46_07675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FXF46_07680	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FXF46_07685	COG0539	negative regulation of cytoplasmic translation
FXF46_07695	COG1215	transferase activity, transferring glycosyl groups
FXF46_07710	COG0612	Peptidase, M16
FXF46_07720	COG0438	transferase activity, transferring glycosyl groups
FXF46_07735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FXF46_07775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FXF46_07775	COG2010	Cytochrome c
FXF46_07785	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FXF46_07795	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FXF46_07805	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FXF46_07820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FXF46_07830	COG1609	Transcriptional regulator
FXF46_07840	COG0640	Transcriptional regulator
FXF46_07845	COG0450	alkyl hydroperoxide reductase
FXF46_07865	COG3620	sequence-specific DNA binding
FXF46_07890	COG5001	Diguanylate cyclase
FXF46_07915	COG4774	siderophore transport
FXF46_07930	COG3128	pkhd-type hydroxylase
FXF46_07940	COG0848	biopolymer transport protein
FXF46_07955	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FXF46_07970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FXF46_07970	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FXF46_07975	COG1494	fructose-1,6-bisphosphatase
FXF46_07985	COG0436	Aminotransferase
FXF46_07995	COG0740	serine-type endopeptidase activity
FXF46_08005	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FXF46_08015	COG1684	flagellar biosynthetic protein fliR
FXF46_08020	COG1987	bacterial-type flagellum assembly
FXF46_08025	COG1677	Flagellar hook-basal body complex protein FliE
FXF46_08030	COG1558	bacterial-type flagellum-dependent cell motility
FXF46_08035	COG1815	bacterial-type flagellum-dependent cell motility
FXF46_08045	COG1338	Plays a role in the flagellum-specific transport system
FXF46_08050	COG0405	Gamma-glutamyltransferase
FXF46_08060	COG5001	Diguanylate cyclase
FXF46_08065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FXF46_08070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FXF46_08085	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FXF46_08090	COG0602	queuosine metabolic process
FXF46_08120	COG0840	transmembrane signaling receptor activity
FXF46_08135	COG2198	Histidine kinase
FXF46_08135	COG0643	Histidine kinase
FXF46_08140	COG0835	chemotaxis
FXF46_08145	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FXF46_08150	COG2201	protein-glutamate methylesterase activity
FXF46_08155	COG0745	RESPONSE REGULATOR receiver
FXF46_08170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FXF46_08185	COG0741	lytic transglycosylase activity
FXF46_08195	COG1238	metal cluster binding
FXF46_08205	COG0793	Belongs to the peptidase S41A family
FXF46_08205	COG3409	Peptidoglycan-binding domain 1 protein
FXF46_08215	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FXF46_08220	COG4133	protoheme IX ABC transporter activity
FXF46_08230	COG0765	amino acid transport
FXF46_08240	COG0542	response to heat
FXF46_08250	COG0779	Required for maturation of 30S ribosomal subunits
FXF46_08265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FXF46_08270	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FXF46_08275	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FXF46_08280	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FXF46_08285	COG1185	polyribonucleotide nucleotidyltransferase activity
FXF46_08320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FXF46_08325	COG3158	transport of potassium into the cell
FXF46_08330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FXF46_08340	COG2205	protein histidine kinase activity
FXF46_08345	COG0745	RESPONSE REGULATOR receiver
FXF46_08350	COG2186	Transcriptional regulator
FXF46_08355	COG1131	(ABC) transporter
FXF46_08365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FXF46_08370	COG2205	protein histidine kinase activity
FXF46_08400	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FXF46_08410	COG0438	transferase activity, transferring glycosyl groups
FXF46_08415	COG0667	Aldo Keto reductase
FXF46_08425	COG0523	cobalamin synthesis protein
FXF46_08440	COG2318	DinB family
FXF46_08450	COG0671	phosphoesterase, PA-phosphatase related
FXF46_08460	COG1760	l-serine dehydratase
FXF46_08465	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FXF46_08470	COG1230	cation diffusion facilitator family transporter
FXF46_08490	COG1131	(ABC) transporter
FXF46_08505	COG2862	Uncharacterized protein family, UPF0114
FXF46_08510	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FXF46_08520	COG3706	GGDEF domain
FXF46_08520	COG4251	negative regulation of phosphorylation
FXF46_08520	COG5001	Diguanylate cyclase
FXF46_08520	COG2203	Gaf domain
FXF46_08530	COG1741	Belongs to the pirin family
FXF46_08535	COG0583	DNA-binding transcription factor activity
FXF46_08540	COG0156	8-amino-7-oxononanoate synthase activity
FXF46_08560	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FXF46_08565	COG0140	phosphoribosyl-ATP diphosphatase activity
FXF46_08575	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FXF46_08580	COG3706	GGDEF domain
FXF46_08595	COG0114	fumarate hydratase activity
FXF46_08610	COG3088	subunit of a heme lyase
FXF46_08615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXF46_08620	COG1138	Cytochrome C-type biogenesis protein
FXF46_08625	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FXF46_08630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FXF46_08655	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FXF46_08675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FXF46_08685	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FXF46_08690	COG0564	pseudouridine synthase activity
FXF46_08705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FXF46_08705	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FXF46_08735	COG1252	NADH dehydrogenase
FXF46_08740	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FXF46_08745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXF46_08750	COG0653	protein targeting
FXF46_08755	COG0217	transcriptional regulatory protein
FXF46_08760	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FXF46_08765	COG0632	four-way junction helicase activity
FXF46_08770	COG2255	four-way junction helicase activity
FXF46_08775	COG0824	Thioesterase
FXF46_08780	COG0811	peptide transport
FXF46_08785	COG0848	biopolymer transport protein
FXF46_08795	COG0823	Involved in the tonB-independent uptake of proteins
FXF46_08800	COG2885	chlorophyll binding
FXF46_08810	COG0037	tRNA processing
FXF46_08820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FXF46_08825	COG0352	thiamine-phosphate diphosphorylase activity
FXF46_08825	COG0351	phosphomethylpyrimidine kinase
FXF46_08830	COG0745	RESPONSE REGULATOR receiver
FXF46_08835	COG1157	protein secretion by the type III secretion system
FXF46_08855	COG2309	aminopeptidase activity
FXF46_08875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FXF46_08895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FXF46_08900	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FXF46_08905	COG0561	phosphatase activity
FXF46_08910	COG0363	glucosamine-6-phosphate deaminase activity
FXF46_08915	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FXF46_08920	COG3265	gluconokinase activity
FXF46_08925	COG1671	Belongs to the UPF0178 family
FXF46_08930	COG0583	DNA-binding transcription factor activity
FXF46_08935	COG1012	belongs to the aldehyde dehydrogenase family
FXF46_08940	COG0693	protein deglycase activity
FXF46_08950	COG0584	glycerophosphoryl diester phosphodiesterase
FXF46_08975	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FXF46_08980	COG5510	response to toxic substance
FXF46_08985	COG2814	Major facilitator Superfamily
FXF46_09005	COG1704	LemA family
FXF46_09010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FXF46_09030	COG0215	cysteine-tRNA ligase activity
FXF46_09040	COG2814	Major facilitator Superfamily
FXF46_09050	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FXF46_09070	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
FXF46_09090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FXF46_09100	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FXF46_09100	COG2885	chlorophyll binding
FXF46_09105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FXF46_09115	COG4974	Belongs to the 'phage' integrase family
FXF46_09120	COG0825	malonyl-CoA metabolic process
FXF46_09165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FXF46_09175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FXF46_09180	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FXF46_09195	COG1758	RNA polymerase activity
FXF46_09200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FXF46_09205	COG0736	holo-[acyl-carrier-protein] synthase activity
FXF46_09210	COG0681	Belongs to the peptidase S26 family
FXF46_09220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FXF46_09225	COG0528	UMP kinase activity
FXF46_09230	COG0233	cytoplasmic translational termination
FXF46_09235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FXF46_09245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FXF46_09250	COG0750	zinc metalloprotease
FXF46_09255	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FXF46_09265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FXF46_09270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FXF46_09275	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FXF46_09280	COG3494	Protein of unknown function (DUF1009)
FXF46_09285	COG0346	lactoylglutathione lyase activity
FXF46_09295	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FXF46_09300	COG0594	ribonuclease P activity
FXF46_09305	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FXF46_09310	COG0706	membrane insertase activity
FXF46_09315	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FXF46_09320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FXF46_09330	COG2171	N-acyltransferase activity
FXF46_09335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FXF46_09345	COG0101	tRNA pseudouridine synthase activity
FXF46_09350	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FXF46_09355	COG0242	peptide deformylase activity
FXF46_09370	COG0251	oxidation-reduction process
FXF46_09385	COG0738	Major facilitator superfamily
FXF46_09390	COG0488	(ABC) transporter
FXF46_09415	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FXF46_09420	COG1137	ATPase activity
FXF46_09435	COG0517	IMP dehydrogenase activity
FXF46_09435	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FXF46_09465	COG0431	NADPH-dependent FMN reductase
FXF46_09495	COG0668	transmembrane transport
FXF46_09505	COG2267	carboxylic ester hydrolase activity
FXF46_09510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FXF46_09510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FXF46_09535	COG1570	exodeoxyribonuclease VII activity
FXF46_09545	COG2824	Alkylphosphonate utilization operon protein PhnA
FXF46_09555	COG1530	ribonuclease E activity
FXF46_09570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FXF46_09575	COG0730	response to heat
FXF46_09605	COG0768	penicillin binding
FXF46_09610	COG0772	Belongs to the SEDS family
FXF46_09615	COG1063	alcohol dehydrogenase
FXF46_09630	COG0752	glycyl-tRNA synthetase alpha subunit
FXF46_09655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FXF46_09670	COG0708	Exodeoxyribonuclease III
FXF46_09675	COG0316	Belongs to the HesB IscA family
FXF46_09680	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FXF46_09685	COG0018	arginyl-trna synthetase
FXF46_09695	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FXF46_09700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FXF46_09705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FXF46_09710	COG0805	protein transport
FXF46_09715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FXF46_09745	COG1289	transmembrane transporter activity
FXF46_09750	COG2267	carboxylic ester hydrolase activity
FXF46_09765	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FXF46_09785	COG1683	Conserved Protein
FXF46_09790	COG1164	Oligoendopeptidase f
FXF46_09795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FXF46_09815	COG0556	nucleotide-excision repair
FXF46_09820	COG2017	converts alpha-aldose to the beta-anomer
FXF46_09835	COG0189	ligase activity
FXF46_09840	COG2226	methyltransferase
FXF46_09850	COG0109	protoheme IX farnesyltransferase activity
FXF46_09860	COG0312	modulator of DNA gyrase
FXF46_09865	COG0612	Peptidase, M16
FXF46_09890	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FXF46_09895	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FXF46_09900	COG0728	peptidoglycan biosynthetic process
FXF46_09915	COG0386	Belongs to the glutathione peroxidase family
FXF46_09920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FXF46_09930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FXF46_09935	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FXF46_09940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FXF46_09945	COG0181	hydroxymethylbilane synthase activity
FXF46_09955	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FXF46_09975	COG1858	cytochrome C peroxidase
FXF46_09985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FXF46_09990	COG1518	maintenance of DNA repeat elements
FXF46_10005	COG1857	crispr-associated protein
FXF46_10020	COG1203	CRISPR-associated helicase, Cas3
FXF46_10040	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FXF46_10050	COG4221	oxidoreductase activity
FXF46_10055	COG0412	Dienelactone hydrolase
FXF46_10065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FXF46_10070	COG0459	protein refolding
FXF46_10085	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FXF46_10095	COG2095	MarC family integral membrane protein
FXF46_10100	COG1573	uracil-dna glycosylase
FXF46_10105	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FXF46_10110	COG0670	Belongs to the BI1 family
FXF46_10125	COG1845	cytochrome c oxidase, subunit III
FXF46_10130	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FXF46_10140	COG0564	pseudouridine synthase activity
FXF46_10140	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FXF46_10150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FXF46_10195	COG0488	(ABC) transporter
FXF46_10200	COG0105	UTP biosynthetic process
FXF46_10205	COG0463	Glycosyl transferase, family 2
FXF46_10210	COG0398	Pfam SNARE associated Golgi protein
FXF46_10220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FXF46_10225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FXF46_10230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FXF46_10235	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FXF46_10250	COG2814	Major facilitator Superfamily
FXF46_10265	COG0019	diaminopimelate decarboxylase activity
FXF46_10270	COG0295	cytidine deaminase activity
FXF46_10280	COG0784	Response regulator, receiver
FXF46_10280	COG4191	Histidine kinase
FXF46_10300	COG0519	Catalyzes the synthesis of GMP from XMP
FXF46_10300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FXF46_10315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FXF46_10320	COG0165	Argininosuccinate lyase
FXF46_10325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXF46_10330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXF46_10345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FXF46_10350	COG0237	dephospho-CoA kinase activity
FXF46_10355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FXF46_10365	COG0438	transferase activity, transferring glycosyl groups
FXF46_10370	COG0367	asparagine synthase
FXF46_10375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FXF46_10400	COG1160	GTP binding
FXF46_10405	COG2814	Major facilitator Superfamily
FXF46_10410	COG2814	Major facilitator Superfamily
FXF46_10420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FXF46_10430	COG3572	ergothioneine biosynthetic process
FXF46_10440	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FXF46_10460	COG1663	tetraacyldisaccharide 4'-kinase activity
FXF46_10465	COG1519	Transferase
FXF46_10480	COG0259	pyridoxamine-phosphate oxidase activity
FXF46_10485	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FXF46_10490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FXF46_10495	COG1764	response to oxidative stress
FXF46_10500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FXF46_10500	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXF46_10510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXF46_10520	COG0142	geranyltranstransferase activity
FXF46_10525	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FXF46_10530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FXF46_10550	COG0406	alpha-ribazole phosphatase activity
FXF46_10555	COG1605	Chorismate mutase
FXF46_10555	COG0287	Prephenate dehydrogenase
FXF46_10565	COG1196	nuclear chromosome segregation
FXF46_10570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXF46_10580	COG1253	flavin adenine dinucleotide binding
FXF46_10585	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FXF46_10590	COG1702	phosphate starvation-inducible protein PhoH
FXF46_10595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FXF46_10605	COG0729	surface antigen
FXF46_10620	COG2204	response regulator
FXF46_10625	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_10630	COG1329	Transcriptional regulator
FXF46_10635	COG3781	membrane
FXF46_10640	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FXF46_10645	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FXF46_10655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FXF46_10675	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FXF46_10690	COG0443	Heat shock 70 kDa protein
FXF46_10695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FXF46_10730	COG2226	methyltransferase
FXF46_10750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FXF46_10755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXF46_10760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FXF46_10770	COG0483	inositol monophosphate 1-phosphatase activity
FXF46_10810	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FXF46_10830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FXF46_10835	COG0318	PFAM AMP-dependent synthetase and ligase
FXF46_10865	COG1648	precorrin-2 dehydrogenase activity
FXF46_10865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FXF46_10870	COG2066	Belongs to the glutaminase family
FXF46_10875	COG4774	siderophore transport
FXF46_10905	COG1914	H( )-stimulated, divalent metal cation uptake system
FXF46_10910	COG1321	iron dependent repressor
FXF46_10920	COG1349	DNA-binding transcription factor activity
FXF46_10925	COG1070	Carbohydrate kinase
FXF46_10930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FXF46_10945	COG1349	DNA-binding transcription factor activity
FXF46_10955	COG4771	TonB-dependent receptor
FXF46_10965	COG4558	Periplasmic binding protein
FXF46_10970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXF46_10975	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FXF46_11000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FXF46_11005	COG0579	oxidoreductase
FXF46_11010	COG0277	FAD linked oxidase domain protein
FXF46_11020	COG0646	methionine synthase
FXF46_11020	COG1410	methionine synthase
FXF46_11035	COG0583	DNA-binding transcription factor activity
FXF46_11040	COG3384	dioxygenase
FXF46_11045	COG2353	YceI-like domain
FXF46_11070	COG1309	transcriptional regulator
FXF46_11075	COG0659	secondary active sulfate transmembrane transporter activity
FXF46_11080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FXF46_11085	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
FXF46_11100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXF46_11115	COG1127	ABC transporter
FXF46_11120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FXF46_11130	COG3706	GGDEF domain
FXF46_11195	COG4335	DNA alkylation repair
FXF46_11220	COG2755	lipolytic protein G-D-S-L family
FXF46_11220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FXF46_11245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXF46_11350	COG3876	Protein conserved in bacteria
FXF46_11380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FXF46_11400	COG3104	oligopeptide transport
FXF46_11410	COG0531	amino acid
FXF46_11425	COG0006	proline dipeptidase activity
FXF46_11435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXF46_11455	COG1802	Transcriptional regulator
FXF46_11465	COG4771	TonB-dependent receptor
FXF46_11495	COG2272	Belongs to the type-B carboxylesterase lipase family
FXF46_11505	COG4948	Mandelate Racemase Muconate Lactonizing
FXF46_11510	COG0145	ligase activity
FXF46_11520	COG2124	cytochrome p450
FXF46_11525	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_11535	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FXF46_11540	COG1304	FMN binding
FXF46_11545	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FXF46_11550	COG0747	negative chemotaxis
FXF46_11555	COG1414	Transcriptional regulator
FXF46_11635	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FXF46_11645	COG1012	belongs to the aldehyde dehydrogenase family
FXF46_11650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FXF46_11655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FXF46_11655	COG0596	Alpha beta hydrolase
FXF46_11655	COG2226	methyltransferase
FXF46_11665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FXF46_11670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FXF46_11685	COG0446	pyridine nucleotide-disulphide oxidoreductase
FXF46_11685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FXF46_11690	COG4311	Sarcosine oxidase, delta subunit
FXF46_11695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXF46_11700	COG0583	DNA-binding transcription factor activity
FXF46_11710	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FXF46_11715	COG2218	PFAM glutamate synthase alpha subunit domain protein
FXF46_11720	COG0069	glutamate synthase activity
FXF46_11765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FXF46_11785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FXF46_11815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FXF46_11820	COG4172	Belongs to the ABC transporter superfamily
FXF46_11835	COG1793	dna ligase
FXF46_11845	COG1201	RNA secondary structure unwinding
FXF46_11860	COG0784	Response regulator, receiver
FXF46_11860	COG4191	Histidine kinase
FXF46_11880	COG3046	protein related to deoxyribodipyrimidine photolyase
FXF46_11920	COG1215	transferase activity, transferring glycosyl groups
FXF46_11930	COG1012	belongs to the aldehyde dehydrogenase family
FXF46_11935	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_11940	COG1309	transcriptional regulator
FXF46_11945	COG3177	Filamentation induced by cAMP protein fic
FXF46_11975	COG0625	glutathione transferase activity
FXF46_11980	COG0625	glutathione transferase activity
FXF46_11990	COG1902	pentaerythritol trinitrate reductase activity
FXF46_11995	COG0625	glutathione transferase activity
FXF46_12000	COG0583	DNA-binding transcription factor activity
FXF46_12060	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FXF46_12090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FXF46_12140	COG1609	Transcriptional regulator
FXF46_12145	COG4771	TonB-dependent receptor
FXF46_12155	COG1082	Xylose isomerase domain protein TIM barrel
FXF46_12200	COG4993	Dehydrogenase
FXF46_12220	COG2205	protein histidine kinase activity
FXF46_12280	COG0583	DNA-binding transcription factor activity
FXF46_12295	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FXF46_12300	COG1984	allophanate hydrolase subunit 2
FXF46_12305	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FXF46_12330	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FXF46_12355	COG1289	transmembrane transporter activity
FXF46_12390	COG0477	Major facilitator Superfamily
FXF46_12410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FXF46_12415	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FXF46_12490	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_12505	COG1063	alcohol dehydrogenase
FXF46_12510	COG1917	Cupin 2, conserved barrel domain protein
FXF46_12510	COG4977	sequence-specific DNA binding
FXF46_12515	COG2814	Major facilitator Superfamily
FXF46_12520	COG3659	wide pore channel activity
FXF46_12525	COG2080	2 iron, 2 sulfur cluster binding
FXF46_12535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FXF46_12540	COG2814	Major facilitator Superfamily
FXF46_12580	COG1522	sequence-specific DNA binding
FXF46_12595	COG1538	Outer membrane efflux protein
FXF46_12600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXF46_12615	COG2207	Transcriptional regulator
FXF46_12655	COG0149	triose-phosphate isomerase activity
FXF46_12660	COG1349	DNA-binding transcription factor activity
FXF46_12675	COG1129	ABC transporter
FXF46_12680	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXF46_12685	COG2376	Dihydroxyacetone kinase
FXF46_12730	COG1116	anion transmembrane transporter activity
FXF46_12730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FXF46_12735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FXF46_12745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FXF46_12755	COG0583	DNA-binding transcription factor activity
FXF46_12765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FXF46_12785	COG1960	acyl-CoA dehydrogenase activity
FXF46_12790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FXF46_12795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FXF46_12800	COG1116	anion transmembrane transporter activity
FXF46_12815	COG4774	siderophore transport
FXF46_12840	COG1301	dicarboxylic acid transport
FXF46_12860	COG0402	S-adenosylhomocysteine deaminase activity
FXF46_12920	COG0583	DNA-binding transcription factor activity
FXF46_12940	COG0778	Nitroreductase
FXF46_12955	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FXF46_12960	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FXF46_13005	COG2099	Precorrin-6x reductase
FXF46_13025	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FXF46_13030	COG1797	cobyrinic acid a,c-diamide synthase activity
FXF46_13040	COG1492	cobalamin metabolic process
FXF46_13045	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FXF46_13090	COG3459	Glycosyltransferase 36 associated
FXF46_13095	COG0058	SHG alpha-glucan phosphorylase activity
FXF46_13115	COG4774	siderophore transport
FXF46_13130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXF46_13135	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_13145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FXF46_13160	COG3191	aminopeptidase activity
FXF46_13165	COG4608	Belongs to the ABC transporter superfamily
FXF46_13185	COG0747	negative chemotaxis
FXF46_13195	COG4771	TonB-dependent receptor
FXF46_13210	COG2814	Major facilitator Superfamily
FXF46_13225	COG4302	ethanolamine ammonia-lyase activity
FXF46_13230	COG4303	Ethanolamine ammonia lyase large subunit
FXF46_13240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FXF46_13250	COG0339	signal peptide processing
FXF46_13255	COG1858	cytochrome C peroxidase
FXF46_13265	COG0306	phosphate transporter
FXF46_13270	COG4774	siderophore transport
FXF46_13275	COG3511	phospholipase C
FXF46_13280	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_13285	COG3842	ATPase activity
FXF46_13305	COG1069	ribulokinase activity
FXF46_13330	COG1335	isochorismatase
FXF46_13345	COG0402	S-adenosylhomocysteine deaminase activity
FXF46_13350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FXF46_13355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FXF46_13355	COG1116	anion transmembrane transporter activity
FXF46_13380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FXF46_13390	COG2249	NAD(P)H dehydrogenase (quinone) activity
FXF46_13400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FXF46_13430	COG1064	alcohol dehydrogenase
FXF46_13445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FXF46_13470	COG0523	cobalamin synthesis protein
FXF46_13475	COG0723	plastoquinol--plastocyanin reductase activity
FXF46_13480	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FXF46_13495	COG1858	cytochrome C peroxidase
FXF46_13505	COG2321	neutral zinc metallopeptidase
FXF46_13525	COG0420	3'-5' exonuclease activity
FXF46_13550	COG1252	NADH dehydrogenase
FXF46_13555	COG0477	Major facilitator Superfamily
FXF46_13570	COG1473	amidohydrolase
FXF46_13575	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FXF46_13585	COG2252	PERMEase
FXF46_13600	COG0840	transmembrane signaling receptor activity
FXF46_13605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FXF46_13630	COG1278	Cold shock
FXF46_13680	COG0697	spore germination
FXF46_13700	COG0135	phosphoribosylanthranilate isomerase activity
FXF46_13705	COG0284	orotidine-5'-phosphate decarboxylase activity
FXF46_13720	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FXF46_13735	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FXF46_13740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FXF46_13760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FXF46_13775	COG0469	pyruvate kinase activity
FXF46_13780	COG0287	Prephenate dehydrogenase
FXF46_13790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXF46_13795	COG1215	transferase activity, transferring glycosyl groups
FXF46_13800	COG1562	ergosterol biosynthetic process
FXF46_13805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FXF46_13815	COG1562	ergosterol biosynthetic process
FXF46_13820	COG1233	COG1233 Phytoene dehydrogenase and related
FXF46_13825	COG1657	PFAM Prenyltransferase squalene oxidase
FXF46_13840	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FXF46_13860	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FXF46_13860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FXF46_13880	COG0745	RESPONSE REGULATOR receiver
FXF46_13895	COG0322	excinuclease ABC activity
FXF46_13900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FXF46_13910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FXF46_13915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FXF46_13925	COG0148	phosphopyruvate hydratase activity
FXF46_13935	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FXF46_13940	COG0504	CTP synthase activity
FXF46_13950	COG0149	triose-phosphate isomerase activity
FXF46_13960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FXF46_13970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FXF46_13975	COG0134	indole-3-glycerol-phosphate synthase activity
FXF46_13980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FXF46_13985	COG0022	dehydrogenase e1 component
FXF46_13985	COG0508	dehydrogenase complex catalyzes the overall conversion of
FXF46_13990	COG0508	dehydrogenase complex catalyzes the overall conversion of
FXF46_13995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FXF46_14000	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FXF46_14005	COG2867	negative regulation of translational initiation
FXF46_14015	COG1546	Belongs to the CinA family
FXF46_14015	COG1058	Belongs to the CinA family
FXF46_14025	COG0861	Integral membrane protein TerC family
FXF46_14030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FXF46_14035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FXF46_14040	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FXF46_14050	COG0047	phosphoribosylformylglycinamidine synthase activity
FXF46_14055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FXF46_14060	COG0271	Belongs to the BolA IbaG family
FXF46_14065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FXF46_14075	COG0792	nuclease activity
FXF46_14080	COG0113	porphobilinogen synthase activity
FXF46_14085	COG0531	amino acid
FXF46_14090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FXF46_14100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FXF46_14110	COG0438	transferase activity, transferring glycosyl groups
FXF46_14115	COG0513	Belongs to the DEAD box helicase family
FXF46_14340	COG3728	DNA packaging
FXF46_14340	COG5484	DNA packaging
FXF46_14370	COG1598	PFAM Uncharacterised protein family UPF0150
FXF46_14395	COG0305	Participates in initiation and elongation during chromosome replication
FXF46_14530	COG3706	GGDEF domain
FXF46_14535	COG2271	Major facilitator Superfamily
FXF46_14550	COG1070	Carbohydrate kinase
FXF46_14580	COG1278	Cold shock
FXF46_14595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FXF46_14600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FXF46_14605	COG0154	amidase activity
FXF46_14610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FXF46_14635	COG0577	efflux transmembrane transporter activity
FXF46_14635	COG1136	(ABC) transporter
FXF46_14640	COG0577	efflux transmembrane transporter activity
FXF46_14645	COG1136	(ABC) transporter
FXF46_14645	COG0577	efflux transmembrane transporter activity
FXF46_14655	COG2204	response regulator
FXF46_14660	COG5000	phosphorelay sensor kinase activity
FXF46_14695	COG2264	protein methyltransferase activity
FXF46_14705	COG2003	Belongs to the UPF0758 family
FXF46_14715	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FXF46_14720	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FXF46_14735	COG0071	Belongs to the small heat shock protein (HSP20) family
FXF46_14740	COG0254	rRNA binding
FXF46_14745	COG1970	mechanosensitive ion channel activity
FXF46_14760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FXF46_14775	COG0784	Response regulator, receiver
FXF46_14795	COG4988	ABC transporter
FXF46_14800	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FXF46_14810	COG0514	ATP-dependent DNA helicase (RecQ)
FXF46_14820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FXF46_14825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FXF46_14830	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FXF46_14845	COG0837	glucose binding
FXF46_14865	COG0525	valine-tRNA ligase activity
FXF46_14875	COG0129	dihydroxy-acid dehydratase activity
FXF46_14885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FXF46_14890	COG1116	anion transmembrane transporter activity
FXF46_14900	COG0756	dUTP diphosphatase activity
FXF46_14905	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FXF46_14910	COG2226	methyltransferase
FXF46_14915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FXF46_14920	COG0268	Binds directly to 16S ribosomal RNA
FXF46_14925	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FXF46_14930	COG0592	DNA-directed DNA polymerase activity
FXF46_14935	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FXF46_14940	COG0187	DNA topoisomerase II activity
FXF46_14950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FXF46_14955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FXF46_14960	COG0247	lactate metabolic process
FXF46_14960	COG0277	FAD linked oxidase domain protein
FXF46_14980	COG2022	thiamine diphosphate biosynthetic process
FXF46_14985	COG0352	thiamine-phosphate diphosphorylase activity
FXF46_15005	COG1234	tRNA 3'-trailer cleavage
FXF46_15010	COG0084	hydrolase, TatD family'
FXF46_15015	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FXF46_15025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FXF46_15030	COG1686	Belongs to the peptidase S11 family
FXF46_15040	COG2951	lytic endotransglycosylase activity
FXF46_15060	COG1968	undecaprenyl-diphosphatase activity
FXF46_15065	COG0531	amino acid
FXF46_15090	COG2890	protein-(glutamine-N5) methyltransferase activity
FXF46_15100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FXF46_15105	COG0124	histidyl-tRNA synthetase
FXF46_15110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FXF46_15120	COG2070	2-Nitropropane dioxygenase
FXF46_15130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FXF46_15135	COG2706	6-phosphogluconolactonase activity
FXF46_15145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FXF46_15175	COG0321	lipoyl(octanoyl) transferase activity
FXF46_15190	COG0484	heat shock protein binding
FXF46_15220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FXF46_15230	COG3300	MHYT domain
FXF46_15230	COG5001	Diguanylate cyclase
FXF46_15240	COG1278	Cold shock
FXF46_15245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FXF46_15250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXF46_15260	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FXF46_15270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FXF46_15285	COG0626	cystathionine gamma-synthase activity
FXF46_15290	COG2897	thiosulfate sulfurtransferase activity
FXF46_15295	COG0628	permease
FXF46_15305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FXF46_15310	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FXF46_15315	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FXF46_15325	COG1381	Involved in DNA repair and RecF pathway recombination
FXF46_15330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FXF46_15335	COG0052	Belongs to the universal ribosomal protein uS2 family
FXF46_15340	COG0587	DNA-directed DNA polymerase activity
FXF46_15345	COG1136	(ABC) transporter
FXF46_15355	COG0442	prolyl-tRNA aminoacylation
FXF46_15365	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FXF46_15370	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FXF46_15370	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FXF46_15380	COG0776	regulation of translation
FXF46_15390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FXF46_15395	COG0740	serine-type endopeptidase activity
FXF46_15400	COG0544	peptidyl-prolyl cis-trans isomerase activity
FXF46_15410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FXF46_15410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FXF46_15425	COG0513	Belongs to the DEAD box helicase family
FXF46_15430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FXF46_15435	COG0316	Belongs to the HesB IscA family
FXF46_15440	COG2151	metal-sulfur cluster biosynthetic enzyme
FXF46_15445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FXF46_15450	COG0719	Fe-S assembly protein
FXF46_15455	COG0396	ATPase activity
FXF46_15460	COG0719	Fe-S assembly protein
FXF46_15470	COG2733	membrane
FXF46_15485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FXF46_15490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FXF46_15495	COG5265	(ABC) transporter
FXF46_15510	COG0628	permease
FXF46_15525	COG0776	regulation of translation
FXF46_15530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FXF46_15535	COG0416	fatty acid biosynthetic process
FXF46_15540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FXF46_15555	COG2205	protein histidine kinase activity
FXF46_15560	COG0745	RESPONSE REGULATOR receiver
FXF46_15570	COG0242	peptide deformylase activity
FXF46_15575	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FXF46_15710	COG0587	DNA-directed DNA polymerase activity
FXF46_15720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FXF46_15755	COG3177	Filamentation induced by cAMP protein fic
FXF46_15760	COG1309	transcriptional regulator
FXF46_15765	COG1028	Short-chain dehydrogenase reductase Sdr
FXF46_15770	COG1012	belongs to the aldehyde dehydrogenase family
FXF46_15780	COG1215	transferase activity, transferring glycosyl groups
FXF46_15820	COG0789	Transcriptional regulator
FXF46_15880	COG4771	TonB-dependent receptor
FXF46_15885	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FXF46_15895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FXF46_15905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FXF46_15930	COG0596	Alpha beta hydrolase
FXF46_15935	COG2267	carboxylic ester hydrolase activity
FXF46_15945	COG1802	Transcriptional regulator
FXF46_15950	COG1979	alcohol dehydrogenase
FXF46_15965	COG0477	Major facilitator Superfamily
FXF46_15980	COG0583	DNA-binding transcription factor activity
FXF46_15990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXF46_16070	COG4957	zinc ion binding
FXF46_16135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FXF46_16155	COG0583	DNA-binding transcription factor activity
FXF46_16160	COG2149	membrane
FXF46_16185	COG1475	DNA binding
FXF46_16195	COG2337	Toxic component of a toxin-antitoxin (TA) module
FXF46_16280	COG0210	DNA helicase
FXF46_16330	COG3750	Belongs to the UPF0335 family
FXF46_16370	COG0629	single-stranded DNA binding
FXF46_16540	COG1061	Type III restriction enzyme res subunit
FXF46_16545	COG1002	Type II restriction enzyme, methylase subunits
FXF46_16550	COG0587	DNA-directed DNA polymerase activity
FXF46_16600	COG1104	cysteine desulfurase activity
FXF46_16610	COG2161	toxin-antitoxin pair type II binding
FXF46_16615	COG1475	DNA binding
FXF46_16645	COG0629	single-stranded DNA binding
FXF46_16670	COG4957	zinc ion binding
FXF46_16705	COG0629	single-stranded DNA binding
FXF46_16805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FXF46_16925	COG0640	Transcriptional regulator
FXF46_16935	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs