locus-tag class description BV122_1 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BV122_1000 ENOG4105S10 periplasmic binding protein BV122_1001 ENOG4105S10 periplasmic binding protein BV122_1002 ENOG4105EHG Permease protein BV122_1003 ENOG4105EHG Permease protein BV122_1004 ENOG4108W0P ABC transporter BV122_1005 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein BV122_1006 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BV122_1008 ENOG41068D6 Glycosyltransferase BV122_1009 ENOG4105W1T Glycosyl Transferase BV122_101 ENOG4105DVA methyltransferase BV122_1010 ENOG4105EX9 Membrane BV122_1012 ENOG4105CI3 gtp-binding protein typa BV122_1013 ENOG4105I85 Bifunctional alpha-2,3 -2,8-sialyltransferase BV122_1015 ENOG4105C5F glutamine synthetase BV122_1016 ENOG4105C1B dTDP-glucose 4-6-dehydratase BV122_1020 ENOG4105QYV Membrane BV122_1022 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BV122_1024 ENOG4105EAH synthase BV122_1025 ENOG4105WPN DNA integration recombination invertion protein BV122_1026 ENOG4105BZG amino acid carrier protein BV122_1027 ENOG41065U4 response regulator BV122_1029 ENOG4105MGM doxx family BV122_103 ENOG4107QKW extracellular solute-binding protein family 1 BV122_1030 ENOG4105DC1 bifunctional purine biosynthesis protein purh BV122_1031 ENOG4105C12 Phosphoribosylglycinamide synthetase BV122_1034 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BV122_1037 ENOG4105Y7M Transcriptional regulator, TetR family BV122_1038 ENOG4105Y7M Transcriptional regulator, TetR family BV122_1039 ENOG410624X efflux transporter, rnd family, mfp subunit BV122_104 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component BV122_1040 ENOG4105BZS acriflavin resistance protein BV122_1041 ENOG41063M6 Cell Division Protein BV122_1042 ENOG4105C0R drug resistance transporter emrb qaca subfamily BV122_1043 ENOG4105CW7 secretion protein, HlyD family BV122_1045 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BV122_1048 ENOG4105HF0 Membrane BV122_1049 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BV122_105 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BV122_1051 ENOG4108Z6B deaminase BV122_1054 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BV122_1055 ENOG4105M6F mutator MutT protein BV122_1056 ENOG4105CKD glutathione-regulated potassium-efflux system protein BV122_1057 ENOG4105DMQ Methyltransferase BV122_1062 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BV122_1063 ENOG4105DZP Membrane-associated zinc metalloprotease BV122_1064 ENOG4105KNE Phosphatidate cytidylyltransferase BV122_1065 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BV122_1069 ENOG4105DJF DNA polymerase III, delta' subunit BV122_1072 ENOG4105WDY DNA (cytosine-5-)-methyltransferase BV122_1073 ENOG41063VX Inherit from COG: glutaredoxin-related protein BV122_1075 ENOG4105CH6 catalase BV122_1076 ENOG4106032 Glutathionylspermidine synthase BV122_1078 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) BV122_108 ENOG4105KUZ arsenate reductase BV122_1080 ENOG4105CBX hi0933 family BV122_1081 ENOG4108DMF Cytochrome C biogenesis protein BV122_1082 ENOG4107QX9 Thiol disulfide interChange protein BV122_1083 ENOG4105DA4 cytochrome c-type biogenesis protein BV122_1084 ENOG4105ECY inositol monophosphatase BV122_1089 ENOG4105DSY exodeoxyribonuclease V, gamma BV122_109 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BV122_1091 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BV122_1092 ENOG4105C0H protease BV122_1094 ENOG4105DY8 decarboxylase BV122_1097 ENOG4108JPW Aminotransferase BV122_11 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BV122_110 ENOG4107QNR UPF0135 protein BV122_1101 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BV122_1105 ENOG4107RYR Transcriptional regulator, Crp Fnr family BV122_1106 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) BV122_1107 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) BV122_1109 ENOG4105K59 histidine triad (HIT) protein BV122_111 ENOG4105CVR type I restriction-modification system BV122_1111 ENOG4105DTN riboflavin biosynthesis protein ribF BV122_1112 ENOG4105CJR Integral membrane protein (MviN BV122_1115 ENOG4108IPT Naphthoate synthase BV122_1116 ENOG4105DNI Converts SHCHC to OSB (By similarity) BV122_1118 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein BV122_1119 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BV122_1120 ENOG4105RG0 Membrane BV122_1121 ENOG4108IA2 Sodium pantothenate symporter BV122_1123 ENOG4105MZU cell filamentation protein BV122_1125 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BV122_1131 ENOG4105C79 DNA protecting protein DprA BV122_1132 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BV122_1133 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BV122_1135 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BV122_1138 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BV122_1139 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BV122_1140 ENOG4108MVK Receptor BV122_1143 ENOG4105VG0 50S ribosomal protein l34 BV122_1144 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BV122_1148 ENOG4105EIN peptidylprolyl cis-trans isomerase BV122_1149 ENOG4108I6E Sulfatase BV122_115 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY BV122_1150 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BV122_1152 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein BV122_1153 ENOG4105DP9 ABC transporter BV122_1154 ENOG4106SMU thiamine transporter membrane protein BV122_1155 ENOG4107T0D ABC, transporter BV122_1157 ENOG4105CV1 Transketolase (EC 2.2.1.1) BV122_1159 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase BV122_1160 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase BV122_1161 ENOG4105CMG Carbohydrate kinase BV122_1162 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BV122_1163 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BV122_1164 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter BV122_1165 ENOG4105DG4 malate L-lactate dehydrogenase BV122_1166 ENOG41069M3 Transcriptional regulator BV122_1167 ENOG4105EAC phosphoserine phosphatase BV122_1168 ENOG4108VPT UPF0234 protein BV122_117 ENOG4108JU6 CBS domain protein BV122_1170 ENOG4108VIA integral membrane protein BV122_1171 ENOG4105E7A Glutamine amidotransferase BV122_1172 ENOG4105E4P ATPase (AAA BV122_1177 ENOG4105N1P Ferredoxin-type protein BV122_1178 ENOG4108NEM leader-binding protein dmsD BV122_1179 ENOG4107KGK dmso reductase anchor subunit BV122_118 ENOG4107XM3 UPF0442 protein BV122_1180 ENOG4105QAX Iron-sulfur BV122_1181 ENOG4105QAX Iron-sulfur BV122_1182 ENOG4107QY8 reductase BV122_1183 ENOG4108KS2 transglutaminase domain protein BV122_1185 ENOG410681U heavy metal transport detoxification protein BV122_1186 ENOG4105BZ1 (ABC) transporter BV122_1187 ENOG4105E7U AraC family transcriptional regulator BV122_1189 ENOG4107J0C type IIi BV122_119 ENOG4107XM3 UPF0442 protein BV122_1190 ENOG4107QMH DNA methylase BV122_1192 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BV122_1193 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BV122_1194 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BV122_1195 ENOG4108I6E Sulfatase BV122_1197 ENOG4105DVI reductase, NrfD BV122_1198 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BV122_1199 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit BV122_12 ENOG4108WPU DNA polymerase III subunit psi BV122_1200 ENOG4105EAU Plays a role in nitrite reduction (By similarity) BV122_1201 ENOG4105CQ7 ATP-dependent helicase BV122_1202 ENOG4105M08 Membrane BV122_1204 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BV122_1205 ENOG4105C4M (Ubiquinol oxidase) subunit I BV122_1208 ENOG4105CDA abc transporter atp-binding protein BV122_1209 ENOG4105E5Q amino acid AbC transporter BV122_1210 ENOG4105EAB amino acid AbC transporter BV122_1212 ENOG4105VFK BolA family BV122_1214 ENOG4105E3I toluene tolerance BV122_1215 ENOG4107PE3 Mammalian cell entry related domain protein BV122_1216 ENOG4105CY3 ABC transporter, permease BV122_1217 ENOG4105DHJ ABC, transporter BV122_1218 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BV122_1219 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) BV122_122 ENOG4108K3A Glutathione S-transferase BV122_1220 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) BV122_1221 ENOG41060IM Heme exporter protein BV122_1222 ENOG4105X3C heme exporter protein BV122_1223 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) BV122_1224 ENOG4105DA4 cytochrome c-type biogenesis protein BV122_1225 ENOG4107QX9 Thiol disulfide interChange protein BV122_1226 ENOG4108M1T Cytochrome c-type biogenesis protein BV122_1227 ENOG4108M1T Cytochrome c-type biogenesis protein BV122_123 ENOG4105X58 receptor BV122_1234 ENOG4105C6T cysteine synthase BV122_1235 ENOG4107RGD Major Facilitator superfamily BV122_1236 ENOG4105XA0 heptosyltransferase ii BV122_1237 ENOG4105T16 Transcriptional regulator (AraC family) BV122_1238 ENOG4105DFD Na H antiporter BV122_1239 ENOG4105C87 Aminotransferase class I and II BV122_1241 ENOG4105CMG Carbohydrate kinase BV122_1243 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BV122_1245 ENOG4105C0P Mg chelatase subunit ChlI BV122_1247 ENOG4108MJ5 VirK protein BV122_1248 ENOG4108JQ7 (ABC) transporter BV122_1249 ENOG4105C3U ABC transporter BV122_1250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BV122_1251 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BV122_1253 ENOG4108J59 Extracellular solute-binding protein, family 5 BV122_1257 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BV122_1259 ENOG4105CJN penicillin-binding protein BV122_1261 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) BV122_1264 ENOG4105CNI cell division protein FtsW BV122_1269 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) BV122_1270 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BV122_1271 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BV122_1273 ENOG4105CQC Prephenate dehydratase BV122_1275 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN BV122_1276 ENOG4108IUZ ABC transporter BV122_1277 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA BV122_1278 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) BV122_1279 ENOG4105N42 UPF0307 protein BV122_1280 ENOG4105CMS peptidase U62, modulator of DNA gyrase BV122_1281 ENOG4108UGV hypoxanthine phosphoribosyltransferase BV122_1282 ENOG4105CCF Lysine exporter protein (Lyse ygga) BV122_1283 ENOG4107R6U sodium dicarboxylate symporter BV122_1284 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) BV122_1286 ENOG4108JJ8 (ABC) transporter BV122_1287 ENOG4108JJ9 ABC, transporter BV122_1288 ENOG4105C3M thioredoxin reductase BV122_1289 ENOG4107QR8 Thioredoxin BV122_1290 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BV122_1291 ENOG4105KA0 thioesterase Superfamily protein BV122_1292 ENOG4105CQB FAD linked oxidase domain protein BV122_1296 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BV122_1297 ENOG41090HJ UPF0265 protein BV122_1300 ENOG4105DDQ anthranilate synthase BV122_1302 ENOG4105GPY SprT protein BV122_1303 ENOG41065S8 Opacity family porin protein BV122_1306 ENOG4105DMR ABC, transporter BV122_1307 ENOG4105GBT ABC transporter BV122_1308 ENOG4106PMH Extracellular solute-binding protein family 3 BV122_1309 ENOG4105E5Z arginine transporter ATP-binding subunit BV122_1313 ENOG4108JQ7 (ABC) transporter BV122_1314 ENOG4105C3U ABC transporter BV122_1315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BV122_1316 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BV122_1318 ENOG4105C4R Atp-dependent dna helicase BV122_1319 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BV122_1320 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BV122_1323 ENOG4105CM2 brancheD-chain amino acid aminotransferase BV122_1324 ENOG4105ETT transcriptional Regulator, LysR family BV122_1325 ENOG4105ETT transcriptional Regulator, LysR family BV122_1328 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BV122_1329 ENOG4107RTD sua5 ycio yrdc ywlc family protein BV122_133 ENOG4105CA3 membrane-bound lytic murein transglycosylase BV122_1330 ENOG4105FE9 pseudouridine synthase BV122_1331 ENOG4107R11 Transcriptional regulator BV122_1332 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) BV122_1333 ENOG4108DG9 Smr protein MutS2 BV122_1334 ENOG4108DNC Involved in acetate metabolism (By similarity) BV122_1336 ENOG4105PQ6 UPF0208 membrane protein BV122_1337 ENOG4105E96 Colicin v production protein BV122_1338 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase BV122_1339 ENOG4105ECP epimerase BV122_134 ENOG4105CUZ uba thif-type nad fad binding protein BV122_1344 ENOG4105T95 Thiol disulfide interChange protein BV122_1345 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BV122_1349 ENOG4105DAA L-lactate BV122_135 ENOG4105NXV High-affinity zinc uptake system protein BV122_1350 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 BV122_1352 ENOG4105HMI Membrane BV122_1354 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein BV122_1355 ENOG4108EU3 peptide transport system, permease BV122_1357 ENOG4108EVY peptide transport periplasmic protein BV122_1358 ENOG4105CM6 amino acid regulated cytosolic protein BV122_137 ENOG4105DFU Cell wall formation (By similarity) BV122_1371 ENOG4108VD1 dedA family BV122_1372 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III BV122_1373 ENOG4105M4H endoribonuclease L-psp BV122_1374 ENOG4108VTV Inherit from NOG: Membrane BV122_1376 ENOG4105W1Y Transcriptional regulator BV122_1377 ENOG4105UZ0 ABC-type Co2 transport system, periplasmic component BV122_1378 ENOG4108A51 BV122_1379 ENOG4107XQ1 cobalamin (vitamin B12) biosynthesis CbiM protein BV122_138 ENOG4105C28 cystathionine BV122_1381 ENOG4108JJB ABC transporter BV122_1382 ENOG4105CGF Aromatic amino acid aminotransferase BV122_1383 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BV122_1384 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BV122_1387 ENOG4105CD8 aminopeptidase N BV122_1388 ENOG4108R6K riboflavin synthase, subunit alpha BV122_1389 ENOG4107QI1 Mate efflux family protein BV122_139 ENOG4105D3R alkyl hydroperoxide reductase BV122_1392 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BV122_1397 ENOG4105CJ3 phosphate transporter BV122_1398 ENOG4107IX6 phosphate transport regulator BV122_1399 ENOG4109045 doxx family BV122_140 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BV122_1405 ENOG4105CC5 ABC transporter BV122_1406 ENOG4105CC5 ABC transporter BV122_1409 ENOG4106YJS accessory processing protein BV122_1412 ENOG4105I7R Adenylate cyclase BV122_1413 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BV122_1414 ENOG4105EW9 transcriptional regulator AsnC family BV122_1416 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) BV122_1417 ENOG4105D1H recombination factor protein RarA BV122_1419 ENOG4105CIY formyltetrahydrofolate deformylase BV122_1420 ENOG4108SAU DNA-binding protein H-ns BV122_1421 ENOG4107S6Z Na H antiporter BV122_1422 ENOG4105C7K acetolactate synthase BV122_1423 ENOG4108ZP8 Acetolactate synthase small subunit BV122_1424 ENOG4105C75 arginyL-tRNA synthetase BV122_1425 ENOG4105NBI YecM protein BV122_1427 ENOG4108XTF Outer Membrane Lipoprotein BV122_1428 ENOG4107S6X Glycosyl transferase, family 2 BV122_1431 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BV122_1432 ENOG4105CDU Replicative dna helicase BV122_1433 ENOG4105CA9 Pyruvate kinase BV122_144 ENOG4105F0N pyrophosphate phospho-hydrolase BV122_1442 ENOG4108BPE -transporting atpase BV122_1443 ENOG41082ND Uncharacterized protein yjcO BV122_1449 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BV122_145 ENOG4105C7N Xanthine uracil vitamin C permease BV122_1450 ENOG41063JG Transcriptional regulator BV122_1452 ENOG4105C5I Dehydrogenase BV122_1453 ENOG4105D60 lipoprotein releasing system transmembrane protein BV122_1454 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BV122_1456 ENOG4105HSA Protein of unknown function (DUF452) BV122_1457 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BV122_1458 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BV122_1460 ENOG4105D60 lipoprotein releasing system transmembrane protein BV122_1461 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BV122_1464 ENOG4105DYS nad(p)h dehydrogenase (quinone) BV122_1465 ENOG4107XHZ cytoplasmic chaperone TorD family protein BV122_1466 ENOG41069NU Nitroreductase BV122_1467 ENOG4105D07 Signal peptide peptidase, SppA BV122_1468 ENOG4105KPE licD family BV122_1470 ENOG4106MCE EamA-like transporter family BV122_1471 ENOG4108KN0 Choline kinase BV122_1473 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BV122_1474 ENOG41090BQ Glutaredoxin BV122_1476 ENOG4105D6U Sodium Glutamate Symporter BV122_1477 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BV122_1478 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BV122_1479 ENOG4105D1S lipid A biosynthesis BV122_1480 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) BV122_1483 ENOG4105C5H ABC transporter BV122_1485 ENOG4105C5H ABC transporter BV122_1486 ENOG41077A9 carbonic anhydrase BV122_1491 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BV122_1492 ENOG4108ZAI phosphatidylglycerophosphatase a BV122_1493 ENOG4105CCF Lysine exporter protein (Lyse ygga) BV122_1494 ENOG4105XPH Ferredoxin BV122_1496 ENOG4106HX4 BV122_15 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BV122_1500 ENOG4108QBX (LipO)protein BV122_1502 ENOG4106210 phosphatase activity BV122_1503 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BV122_1505 ENOG4105CNU cell division protein FtsK BV122_1506 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BV122_1507 ENOG4108ZF3 Phosphatase BV122_1509 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BV122_151 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BV122_1511 ENOG4105DSB aldose 1-epimerase BV122_1512 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BV122_1513 ENOG41082NX 50s ribosomal protein l35 BV122_1514 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BV122_1515 ENOG4107QKA exodeoxyribonuclease V beta BV122_1516 ENOG4107QYX exodeoxyribonuclease v alpha BV122_1518 ENOG4105DAN ATP-dependent protease BV122_1520 ENOG4105XTM Inherit from NOG: Mn2 dependent serine threonine protein kinase BV122_1526 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase BV122_1527 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BV122_1528 ENOG4105HBR Rna-binding protein BV122_1529 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) BV122_1530 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BV122_1531 ENOG4105EEI dihydropteroate synthase BV122_1533 ENOG4108BY2 phosphohistidine phosphatase BV122_1534 ENOG4106DNW BV122_1535 ENOG4105ENJ RND efflux system, outer membrane lipoprotein BV122_1539 ENOG4108WQI RNA Polymerase BV122_154 ENOG4107RZZ dna polymerase iii epsilon subunit BV122_1543 ENOG4105E0X reductase BV122_1544 ENOG4107QIV Cytochrome c biogenesis protein BV122_1545 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BV122_1546 ENOG4105XW2 UPF0263 protein BV122_1547 ENOG4105D06 uba thif-type nad fad binding protein BV122_1548 ENOG4105CVM Molybdenum cofactor synthesis domain protein BV122_1549 ENOG4105EUJ GTP cyclohydrolase i BV122_1551 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BV122_1552 ENOG4105SYT Methylenetetrahydrofolate reductase BV122_1555 ENOG4107MKT Stringent starvation protein a BV122_1556 ENOG4105KB2 stringent starvation protein b BV122_1559 ENOG4105CTB Polyprenyl synthetase BV122_1562 ENOG4105WP7 tRNA pseudouridine synthase C BV122_1565 ENOG4105VEQ Cold shock protein BV122_1566 ENOG4108Z66 YbaK ebsC protein BV122_1567 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BV122_1568 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BV122_1570 ENOG4105EMU Dehydrogenase BV122_1571 ENOG4105CXB phosphoribosylaminoimidazole synthetase BV122_1572 ENOG4108V3E phosphoribosylglycinamide formyltransferase BV122_1574 ENOG4105Q9Y Universal stress protein BV122_1575 ENOG4105DS0 Transcriptional regulator, Crp Fnr family BV122_158 ENOG4105CE4 GlcNAc 6-P deacetylase BV122_1586 ENOG4105DH7 May be involved in recombination (By similarity) BV122_1591 ENOG4108PNI recT protein BV122_1598 ENOG4105NI8 Cytosine-specific methyltransferase BV122_16 ENOG4105C3F Signal peptidase i BV122_160 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BV122_161 ENOG4105QEK Transcriptional regulator BV122_1622 ENOG41061CV Terminase small subunit BV122_1623 ENOG4108N0N Phage Terminase Large Subunit BV122_1624 ENOG4108N0N Phage Terminase Large Subunit BV122_1625 ENOG4107ZQ5 Phage-associated protein, HI1409 family BV122_1626 ENOG4108C66 Inherit from COG: DNA primase BV122_1627 ENOG41090AG Bacteriophage protein BV122_1629 ENOG4105DB7 PHP domain protein BV122_163 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) BV122_1630 ENOG4105RHG BV122_1631 ENOG4105C9Q fumarate hydratase class II BV122_1633 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BV122_1634 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BV122_1635 ENOG4105MYG DNA polymerase iii, chi subunit BV122_1642 ENOG41082MF Hydrogenase assembly chaperone hypC hupF BV122_1643 ENOG4105DK0 Indole-3-glycerol phosphate synthase BV122_1644 ENOG4107QYG anthranilate phosphoribosyltransferase BV122_1645 ENOG4108V5Q transglutaminase-like protein BV122_1646 ENOG4105DDQ anthranilate synthase BV122_1647 ENOG4105CRQ synthase (Component I) BV122_1649 ENOG41090A1 ferritin BV122_165 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BV122_1650 ENOG41090A1 ferritin BV122_1651 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) BV122_1652 ENOG4105C8U phosphate abc transporter BV122_1653 ENOG4105E2Z phosphate ABC transporter (Permease BV122_1655 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BV122_1656 ENOG4105BZU Histidine kinase BV122_1657 ENOG4105CJB Exodeoxyribonuclease I BV122_1658 ENOG4108TZV Membrane BV122_1659 ENOG4108HFV BV122_1661 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) BV122_1664 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) BV122_1665 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) BV122_1666 ENOG4108Z0T Part of a sulfur-relay system (By similarity) BV122_1667 ENOG4105X1Q TOBE domain protein BV122_1668 ENOG4105PE1 Receptor BV122_1669 ENOG4107RAN Peptidase, M16 BV122_1673 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BV122_1674 ENOG4105CC0 LysR family Transcriptional regulator BV122_1675 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BV122_1676 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BV122_1677 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BV122_168 ENOG4105EPW hflc protein BV122_1681 ENOG4108ESZ Glycogen debranching enzyme BV122_1683 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) BV122_1686 ENOG4105C03 ribonuclease BV122_1687 ENOG4105CK7 Sodium proline symporter BV122_169 ENOG4107QJR hflk protein BV122_1690 ENOG4108RMU ferritin dps family protein BV122_1693 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BV122_1694 ENOG4105F38 ABC transporter, permease BV122_1695 ENOG4105D38 putrescine abc transporter BV122_1696 ENOG4107RUE extracellular solute-binding protein family 1 BV122_1697 ENOG4105C5H ABC transporter BV122_1699 ENOG41067MG lrgb family BV122_1701 ENOG4105KK6 nuclease BV122_1702 ENOG4105C9B Cysteine desulfurase BV122_1703 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) BV122_1704 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein BV122_1706 ENOG4105EHE chorismate mutase- prephenate dehydrogenase BV122_1709 ENOG4105CVR type I restriction-modification system BV122_171 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BV122_1710 ENOG4105EKX Restriction modification system DNA (Specificity BV122_1712 ENOG4105DZR Type I site-specific deoxyribonuclease BV122_1713 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BV122_1714 ENOG4105CHV Transcription elongation factor NusA BV122_173 ENOG4105CHR reductase BV122_174 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BV122_176 ENOG4105VGS 50s ribosomal protein l32 BV122_1768 ENOG4105KUS lysozyme BV122_177 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein BV122_1776 ENOG4105ED4 portal protein BV122_1777 ENOG4105F0R Cytidylyltransferase BV122_1778 ENOG4108RCM Nitroreductase BV122_1779 ENOG4105D1F ATP-binding protein BV122_178 ENOG4105DJ4 phosphatidylserine decarboxylase BV122_1783 ENOG4108BSC Methyltransferase BV122_1784 ENOG4106ZKY BV122_1785 ENOG4105DDY UPF0142 protein ycaO BV122_1786 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BV122_1788 ENOG4107GZ4 SanA protein BV122_1789 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BV122_179 ENOG4105DC8 reductase BV122_1791 ENOG4105C0H protease BV122_1792 ENOG4108JA2 transcriptioN-repair coupling factor BV122_1796 ENOG4105C5H ABC transporter BV122_1797 ENOG4105VDM plasmid maintenance system antidote protein, xre family BV122_1798 ENOG41080ET plasmid maintenance system killer protein BV122_1799 ENOG41065CD Exported protein BV122_180 ENOG4105IEY (LipO)protein BV122_1800 ENOG4105D7X high-affinity nickel-transporter BV122_1803 ENOG4105E0M Sulfatase BV122_1804 ENOG4105C6K Malic enzyme BV122_1805 ENOG4105TWJ Domain of unknown function (DUF1919) BV122_1806 ENOG4105I08 Pseudouridine synthase BV122_1807 ENOG4105C2C drug resistance transporter, Bcr CflA BV122_1809 ENOG4105EN6 Membrane BV122_181 ENOG4105M85 Bola protein BV122_1815 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BV122_1816 ENOG4107QSN dihydrolipoamide acetyltransferase BV122_1817 ENOG4107QN2 dihydrolipoyl dehydrogenase BV122_1819 ENOG4107QMP dna polymerase iii subunits gamma and tau BV122_1821 ENOG4105C2W permease BV122_1822 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) BV122_1823 ENOG4108ZJT translation initiation factor, Sui1 BV122_1825 ENOG4105CFV Tetratricopeptide repeat protein BV122_1826 ENOG4105Q4A inner membrane protein yciS BV122_1828 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BV122_1829 ENOG4105CAT Cytidine monophosphate kinase BV122_1832 ENOG4105CXG d-lactate dehydrogenase BV122_1834 ENOG4107TT5 NLP P60 protein BV122_1835 ENOG4105D1U peptidase U62 modulator of DNA gyrase BV122_1836 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BV122_1837 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) BV122_1839 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BV122_184 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BV122_1840 ENOG4105W4M Transport-associated protein BV122_1841 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BV122_1842 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BV122_1843 ENOG4105C7S Dehydrogenase BV122_1844 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BV122_1845 ENOG4105C5X domain protein BV122_1846 ENOG4108RE7 deoxyribonuclease BV122_1848 ENOG4105DIT ErfK YbiS YcfS YnhG family protein BV122_1849 ENOG4105CN1 protease BV122_1850 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) BV122_1852 ENOG4105H2K paraquat-inducible protein a BV122_1853 ENOG4105DY2 Paraquat-inducible protein b BV122_1854 ENOG4108ZAF Molybdopterin BV122_1855 ENOG4105M00 molybdopterin converting factor, subunit 1 BV122_1857 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BV122_1858 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BV122_1859 ENOG4105C2X Arabinose 5-phosphate isomerase BV122_1860 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase BV122_1863 ENOG4106YJS accessory processing protein BV122_1864 ENOG4105EM2 membrane BV122_1867 ENOG4105ERU peptidase BV122_1870 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) BV122_1870 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) BV122_1873 ENOG4105DZB Electron transport complex BV122_1874 ENOG4105CSM endonuclease III BV122_1875 ENOG4105C8J )-transporter BV122_1876 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) BV122_1877 ENOG4105E0C molybdate abc transporter BV122_1878 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BV122_1879 ENOG4105F4R Transcriptional regulator mode BV122_188 ENOG4105CJ2 (LipO)protein BV122_1880 ENOG4108RYC glycosyltransferase BV122_1881 ENOG4108RJ9 Glycosyl transferase, family 2 BV122_1882 ENOG41068D6 Glycosyltransferase BV122_1883 ENOG4105CG5 Glycosyl transferase (Group 1 BV122_1884 ENOG4105P7J Transfers sialic acid from the substrate CMP-sialic acid donor to the terminal beta-D-galactosyl-1,4-acetyl-beta-D- glucosamine on the lacto-N-neotetraose branch of the lipooligosaccharide BV122_1885 ENOG4108MY6 biosynthesis protein BV122_1886 ENOG41080C8 DUF218 domain BV122_1888 ENOG4108K5H permease YjgP YjgQ family protein BV122_1889 ENOG4108M8S permease YjgP YjgQ family protein BV122_1891 ENOG4105C94 Transporter BV122_1892 ENOG4105DHQ Histidine kinase BV122_1893 ENOG4105XJC Two component transcriptional regulator (Winged helix family BV122_1894 ENOG4105WXI Bacterial OB fold (BOF) protein BV122_1896 ENOG4105C5Y PTS System BV122_1897 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BV122_1898 ENOG4105KZ7 phosphocarrier protein hpr BV122_1903 ENOG4105ESV Glycosyl transferase, family 4 BV122_1905 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BV122_1907 ENOG4108ZIG UPF0231 protein BV122_1908 ENOG4105BZ4 penicillin-binding protein BV122_191 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BV122_1911 ENOG4105C5A transporter BV122_1913 ENOG4107R7A Allophanate hydrolase subunit 2 BV122_1914 ENOG4105P4J Allophanate hydrolase, subunit 1 BV122_1916 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BV122_1918 ENOG4106CC8 Bacterial inner membrane protein BV122_192 ENOG4105C34 Pseudouridine synthase BV122_1920 ENOG4105KMT branched-chain amino acid BV122_1921 ENOG4108UMN azlc family BV122_1922 ENOG4105DZ2 Transcriptional regulator BV122_193 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BV122_1930 ENOG4105CB5 ATP-dependent DNA helicase recG BV122_1931 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BV122_195 ENOG4105F1A Pyruvate formate-lyase BV122_196 ENOG4105C6N Formate acetyltransferase BV122_197 ENOG4105TMB Formate nitrite transporter BV122_199 ENOG4105BZG amino acid carrier protein BV122_2 ENOG4108IQE Amp-dependent synthetase and ligase BV122_200 ENOG4105C4W S-formylglutathione hydrolase BV122_201 ENOG4107QPD alcohol dehydrogenase BV122_202 ENOG4105VUF Transcriptional regulator BV122_205 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BV122_206 ENOG4105D82 Glutamate dehydrogenase BV122_207 ENOG41090R7 Ferric uptake BV122_208 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) BV122_209 ENOG4105EV9 Alpha Beta Hydrolase BV122_210 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) BV122_211 ENOG4105CEY Amp-dependent synthetase and ligase BV122_212 ENOG4105EGS Mechanosensitive ion channel BV122_214 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) BV122_215 ENOG4105EJ9 Membrane BV122_216 ENOG4105EJ9 Membrane BV122_217 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase BV122_22 ENOG4107QPK )-transporter BV122_223 ENOG4106W3N BV122_224 ENOG4105CGH 5'-nucleotidase BV122_227 ENOG4105DFE Dna adenine methylase BV122_228 ENOG4105EYK Phosphatidylglycerophosphatase B BV122_23 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase BV122_230 ENOG4107TSG Extracellular solute-binding protein, family 5 BV122_231 ENOG4105WD1 Membrane BV122_232 ENOG4105DGW oligopeptidase A BV122_238 ENOG4108KBJ Inner membrane protein YkgB BV122_24 ENOG4105CHY citrate lyase, alpha BV122_240 ENOG4108RG0 uracil-dna glycosylase BV122_246 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BV122_247 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BV122_249 ENOG4106KPZ rard protein BV122_25 ENOG4105CI0 Citrate lyase BV122_250 ENOG4105FKN transcriptional regulator, AsnC family BV122_253 ENOG4105CWM branched-chain amino acid transport system II carrier protein BV122_254 ENOG4108R66 Conserved Protein BV122_257 ENOG4105RT1 May be involved in cell division (By similarity) BV122_258 ENOG4105C1J atp-dependent rna helicase BV122_264 ENOG4105K89 arsenate reductase BV122_266 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BV122_267 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BV122_268 ENOG4105VIE preprotein translocase, subunit YajC BV122_27 ENOG4105DUA (citrate (pro-3S)-lyase ligase BV122_270 ENOG4105NSG hemerythrin hhe cation binding domain protein BV122_271 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BV122_275 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BV122_276 ENOG4108UUM single-stranded DNA-binding protein BV122_277 ENOG4108DNJ Pfam:TonB BV122_278 ENOG4105M15 transport protein ExbD BV122_280 ENOG4105M8K biopolymer transport protein BV122_281 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BV122_284 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA BV122_287 ENOG4105X1N Glycosyl transferase family 8 BV122_288 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BV122_290 ENOG4105DKP glycosyl transferase, family 9 BV122_291 ENOG4107ENK receptor BV122_292 ENOG4108D1Y Polypeptide-transport-associated domain protein, ShlB-type BV122_293 ENOG4105IB0 filamentous hemagglutinin family outer membrane protein BV122_294 ENOG4107ZVW dihydroneopterin aldolase BV122_296 ENOG4105BZU Histidine kinase BV122_297 ENOG4105D4A Cell wall formation (By similarity) BV122_298 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BV122_299 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) BV122_3 ENOG410667J hydrolase BV122_30 ENOG4108D64 Protein of unknown function (DUF493) BV122_300 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) BV122_309 ENOG4107T7U Sulfatase BV122_31 ENOG4105DZ1 carboxypeptidase BV122_311 ENOG4105K5B UPF0225 protein BV122_313 ENOG4108I5U Uridine phosphorylase BV122_314 ENOG4105CSH Transporter BV122_315 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BV122_317 ENOG4105E4F Isochorismate synthase BV122_318 ENOG4105CHM Aminotransferase BV122_319 ENOG4105CIC tryptophan-specific transport protein BV122_32 ENOG4105K6T rare lipoprotein A BV122_320 ENOG4105EJQ L-serine dehydratase BV122_321 ENOG4105C44 Serine transporter BV122_322 ENOG4105C59 p-type ATPase BV122_327 ENOG4108Z6Z Transcriptional regulator BV122_329 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BV122_33 ENOG4105CNI cell division protein FtsW BV122_331 ENOG4105D7Q type ii secretion system BV122_332 ENOG4107QHF type ii secretion system protein e BV122_334 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase BV122_335 ENOG4108JU5 Magnesium and cobalt efflux protein BV122_336 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) BV122_337 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BV122_34 ENOG4105CJN penicillin-binding protein BV122_342 ENOG4105II7 pyrroline-5-carboxylate reductase BV122_343 ENOG4105D8G Major Facilitator superfamily BV122_344 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BV122_350 ENOG4108TIT dATP pyrophosphohydrolase BV122_353 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase BV122_357 ENOG4108UYE Lactoylglutathione lyase BV122_359 ENOG4105D3Y Na H antiporter BV122_36 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) BV122_363 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BV122_364 ENOG4108UBT opacity-associated protein BV122_366 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) BV122_367 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BV122_368 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BV122_369 ENOG41080IJ Diacylglycerol kinase BV122_37 ENOG4105D0C transport protein BV122_370 ENOG4108RIR Molybdenum cofactor biosynthesis protein BV122_371 ENOG4108YZA Nitrogen regulatory protein pii BV122_372 ENOG4105DSF transport protein BV122_373 ENOG4105C25 Primosomal protein n' BV122_375 ENOG41090ED Protein with unknown function (DUF469) BV122_379 ENOG4108BGM Quinol dehydrogenase periplasmic component BV122_38 ENOG4105CQ0 ABC transporter BV122_380 ENOG4105GXZ Ferredoxin-type protein NapH BV122_381 ENOG4105IYZ Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) BV122_382 ENOG4105CUW cytochrome C-TYPE protein BV122_384 ENOG4105EYM Major Facilitator superfamily BV122_386 ENOG4105CMR udp-glucose 4-epimerase BV122_387 ENOG4105I85 Bifunctional alpha-2,3 -2,8-sialyltransferase BV122_388 ENOG4108YI8 ABC transporter BV122_389 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component BV122_39 ENOG4105DFF Rod shape-determining protein mreb BV122_390 ENOG4107Z6I Thiamine biosynthesis protein BV122_391 ENOG4105ETU transcriptional activator (TenA BV122_392 ENOG4105CC5 ABC transporter BV122_393 ENOG4105CC5 ABC transporter BV122_394 ENOG4105DIK (ABC) transporter BV122_396 ENOG41061WM D-Alanyl-D-Alanine BV122_399 ENOG41090FY type IV pilus biogenesis stability protein PilW BV122_40 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BV122_400 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) BV122_403 ENOG4105N21 Membrane BV122_404 ENOG4105WVQ Fe-S assembly protein IscX BV122_405 ENOG4108ZIT Ferredoxin, 2FE-2S BV122_407 ENOG4108RF1 Protein of unknown function DUF2625 BV122_408 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) BV122_409 ENOG4108Z4V iron-sulfur cluster assembly BV122_410 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins BV122_412 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family BV122_413 ENOG4105CVS RNA methyltransferase TrmH family, group 1 BV122_42 ENOG4105GXY Family of unknown function (DUF695) BV122_423 ENOG4105WXW Antirepressor BV122_43 ENOG4105CGK Exodeoxyribonuclease III BV122_44 ENOG4108W1A pseudouridine synthase BV122_445 ENOG4105NVB glycoside hydrolase, family 19 BV122_46 ENOG4108MN8 Membrane BV122_460 ENOG4105WXW Antirepressor BV122_463 ENOG4108PNI recT protein BV122_470 ENOG4107V6I Cytosine-specific methyltransferase BV122_472 ENOG4108KU3 Integrase BV122_474 ENOG4105KCK Peptidoglycan-associated lipoprotein BV122_478 ENOG4105E02 MotA TolQ exbB proton channel BV122_479 ENOG4107YD3 Thioesterase BV122_48 ENOG4108UUE Transcriptional regulator BV122_480 ENOG4105DVT helicase BV122_481 ENOG41072GX Peptidase M22 Glycoprotease BV122_482 ENOG4105R8X Outer membrane lipoprotein Slp BV122_483 ENOG4105CEY Amp-dependent synthetase and ligase BV122_484 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) BV122_486 ENOG4105EXC Acyl-transferase BV122_487 ENOG4105C3G gtp-binding protein BV122_488 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BV122_49 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BV122_490 ENOG4105EZE Cupin 4 family protein BV122_492 ENOG41087AY ADP-Ribose pyrophosphatase BV122_493 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) BV122_494 ENOG4105KZW UPF0381 protein BV122_496 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BV122_498 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BV122_50 ENOG4108UHU Aldolase BV122_501 ENOG4105FAV ABC, transporter BV122_502 ENOG4105FDK ABC transporter BV122_503 ENOG4105DR5 peptidase BV122_504 ENOG4108JU8 Transcriptional regulator BV122_505 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BV122_506 ENOG4105EI2 Pseudouridine synthase BV122_508 ENOG4105C03 ribonuclease BV122_51 ENOG4105DMW Dehydrogenase reductase BV122_511 ENOG4105DWF phosphomethylpyrimidine kinase BV122_513 ENOG4105CSH Transporter BV122_514 ENOG4105CFP Peptidase U32 BV122_515 ENOG4105C1J atp-dependent rna helicase BV122_517 ENOG4105EIB trna rrna methyltransferase BV122_518 ENOG4105JIM Phosphatidylserine synthase BV122_52 ENOG4107SS6 2-dehydro-3-deoxygluconokinase BV122_522 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BV122_523 ENOG4105K70 DNA-binding protein BV122_524 ENOG4105R2J Conserved Protein BV122_527 ENOG4105MJ2 Competence protein BV122_528 ENOG4105E4G Type IV pilus BV122_53 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BV122_533 ENOG4108JQC penicillin-binding protein 1A BV122_534 ENOG4105D6S protein involved in catabolism of external DNA BV122_536 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BV122_538 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BV122_54 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter BV122_541 ENOG4105DM4 PTS System BV122_542 ENOG4105DE4 1-phosphofructokinase BV122_543 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein BV122_545 ENOG4105C37 (CBS) domain BV122_546 ENOG4105RX8 Protein of unknown function (DUF1523) BV122_547 ENOG4105F8V Hydrolase, tatD family BV122_548 ENOG4107QRG dna polymerase iii BV122_55 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit BV122_555 ENOG4105HHA aminodeoxychorismate lyase BV122_556 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) BV122_558 ENOG4105DXN mazG family BV122_559 ENOG4108MJ5 VirK protein BV122_56 ENOG4105CPQ Dehydrogenase BV122_560 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BV122_561 ENOG4105CSA Coproporphyrinogen iii oxidase BV122_562 ENOG4105E66 phosphoriboisomerase A BV122_563 ENOG4108JQ1 Dehydrogenase BV122_564 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) BV122_565 ENOG4105DSJ YicC domain protein BV122_57 ENOG4107YCY Transcriptional regulator BV122_573 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BV122_574 ENOG4105E0U tyrosine-specific transport protein BV122_587 ENOG4107VXZ Hydrolase BV122_588 ENOG4105W39 Membrane BV122_59 ENOG4105EE5 Membrane protein terC BV122_590 ENOG4105F0S class B acid phosphatase BV122_593 ENOG4107RUE extracellular solute-binding protein family 1 BV122_594 ENOG4105CJP fad dependent oxidoreductase BV122_595 ENOG4105CGY Dna recombination protein BV122_598 ENOG4105CNN ABC, transporter BV122_599 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BV122_600 ENOG4108RVA ribokinase BV122_601 ENOG4105ETE Transcriptional regulator (LacI family BV122_604 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BV122_605 ENOG4108R96 Methyltransferase, YaeB family BV122_612 ENOG4105D9N nucleoside BV122_613 ENOG41076CZ activating enzyme BV122_614 ENOG4105G0K glycine radical enzyme YjjI family BV122_615 ENOG4105M5K heptosyltransferase BV122_616 ENOG4108VW9 Membrane BV122_617 ENOG4105D2N Aldolase BV122_619 ENOG41083KI ribonuclease, T2 BV122_620 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding BV122_621 ENOG4105E0U tyrosine-specific transport protein BV122_622 ENOG4107104 thymidine kinase BV122_623 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BV122_625 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BV122_626 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BV122_628 ENOG4108IJ0 Aspartate ammonia-lyase BV122_63 ENOG4105BZ1 (ABC) transporter BV122_630 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) BV122_631 ENOG4107Z51 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) BV122_633 ENOG4105CQM Urea amidohydrolase subunit alpha BV122_64 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 BV122_645 ENOG4105XA0 heptosyltransferase ii BV122_646 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BV122_647 ENOG4105W1T Glycosyl Transferase BV122_648 ENOG4105W1T Glycosyl Transferase BV122_65 ENOG4105SVQ Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression (By similarity) BV122_650 ENOG4105WV0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) BV122_651 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BV122_652 ENOG41090HT Inherit from COG: transposase BV122_654 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BV122_657 ENOG4105EPD Oligopeptide transporter, Opt family BV122_658 ENOG4105VEJ Heat shock protein BV122_659 ENOG4108VVK transcriptional Regulator, AsnC BV122_66 ENOG4105DJ0 Poly(A) Polymerase BV122_661 ENOG4105DQ6 Transposase BV122_666 ENOG4105DJV ribulose-phosphate 3-epimerase BV122_667 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BV122_668 ENOG4105BZM domain protein BV122_669 ENOG4108RRZ Transcription elongation factor GreB BV122_67 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BV122_670 ENOG4105EJ2 Transcriptional regulator BV122_671 ENOG4105C5Q Transcriptional regulator BV122_672 ENOG4105EHV domain protein BV122_673 ENOG41069P5 Protein slyX homolog BV122_674 ENOG4108V1T peptidylprolyl cis-trans isomerase BV122_675 ENOG4105WWK YheO domain protein BV122_676 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) BV122_677 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) BV122_68 ENOG4105K8N protein family UPF0079, ATPase BV122_682 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BV122_685 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BV122_686 ENOG4105CH2 amidohydrolase BV122_69 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BV122_690 ENOG4105CSX c4-dicarboxylate anaerobic carrier BV122_691 ENOG4105C5B carbamate kinase BV122_692 ENOG4105DBV ornithine carbamoyltransferase BV122_693 ENOG4105DQF Hydrolase BV122_706 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BV122_707 ENOG4105C1A potassium transporter peripheral membrane BV122_709 ENOG4105Y75 tpr repeat protein BV122_71 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BV122_710 ENOG4105EMN RNA polymerase sigma factor BV122_711 ENOG41069PW sigma-e factor negative regulatory protein BV122_712 ENOG4105VQK sigma E regulatory protein, MucB RseB BV122_713 ENOG4105CS9 pantothenic acid kinase BV122_72 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BV122_722 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BV122_723 ENOG4105KZW UPF0381 protein BV122_724 ENOG4105C31 Tryptophanyl-tRNA synthetase BV122_726 ENOG4107QTF adenylosuccinate lyase BV122_73 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BV122_734 ENOG4107QY8 reductase BV122_735 ENOG4105CUW cytochrome C-TYPE protein BV122_736 ENOG4108EUD Lysophospholipase BV122_737 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BV122_738 ENOG4105KT7 mgtC SapB transporter BV122_739 ENOG4105NF4 modulator of drug activity BV122_740 ENOG4105HEI LysR family (Transcriptional regulator BV122_741 ENOG4105C4R Atp-dependent dna helicase BV122_744 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase BV122_745 ENOG4108R3E Dna-3-methyladenine glycosylase i BV122_746 ENOG4106WTF Glycosyl transferase, family 2 BV122_749 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BV122_75 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BV122_750 ENOG4108WI1 Dna topoisomerase BV122_751 ENOG4105C5H ABC transporter BV122_755 ENOG4108JJ9 ABC, transporter BV122_756 ENOG4105BZ1 (ABC) transporter BV122_757 ENOG4108KSB HipA-like N-terminal domain BV122_758 ENOG4105MHH HipA N-terminal domain protein BV122_759 ENOG4107A4G HTH_XRE BV122_76 ENOG41060A7 DNA polymerase beta domain protein region BV122_760 ENOG4105CBT Fructose-1,6-bisphosphatase BV122_762 ENOG4105QTB Flavodoxin BV122_763 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BV122_768 ENOG4105CIN aminoacyl-histidine dipeptidase BV122_77 ENOG41062MS nucleotidyltransferase substrate binding protein BV122_770 ENOG4108HYK gCN5-related N-acetyltransferase BV122_771 ENOG4105CP7 Triose-phosphate isomerase BV122_774 ENOG4105DTR rard protein BV122_775 ENOG4105EMY transcriptional regulator BV122_777 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BV122_779 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A BV122_78 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BV122_780 ENOG4105CXY transporter BV122_781 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase BV122_782 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BV122_783 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BV122_785 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase BV122_786 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BV122_787 ENOG4108R99 pseudouridine synthase BV122_788 ENOG4105C9X ppx gppa phosphatase BV122_789 ENOG4105MA0 exported protein BV122_79 ENOG4105C29 acyl-CoA thioesterase BV122_790 ENOG4105CFU surface antigen BV122_791 ENOG4108YZY peptidylprolyl cis-trans isomerase BV122_792 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) BV122_795 ENOG4108UM1 dedA family BV122_798 ENOG4108K5P (LipO)protein BV122_8 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BV122_801 ENOG4105CIC tryptophan-specific transport protein BV122_802 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BV122_804 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) BV122_805 ENOG4105EM7 Selenocysteine-specific translation elongation factor BV122_807 ENOG4108MVK Receptor BV122_81 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BV122_810 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BV122_811 ENOG4105PM1 preprotein translocase subunit SecE BV122_812 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BV122_813 ENOG410903C (LipO)protein BV122_814 ENOG4105KME endoribonuclease L-psp BV122_817 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BV122_818 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) BV122_828 ENOG410601J HemY protein BV122_829 ENOG4105ECF c-methyltransferase BV122_83 ENOG4105UIH PemK-like protein BV122_830 ENOG4107T0K Adenylate cyclase BV122_832 ENOG4105D7W serine acetyltransferase BV122_833 ENOG4105F9E Shikimate 5-dehydrogenase BV122_834 ENOG4105C8P )-transporter BV122_838 ENOG4105EDR glucose galactose transporter BV122_839 ENOG4107W7X Aldolase BV122_84 ENOG4105EYA deoxyribonuclease BV122_841 ENOG4105CMG Carbohydrate kinase BV122_842 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) BV122_843 ENOG4107EDW L-fucose operon activator BV122_845 ENOG4105D3G Pseudouridine synthase BV122_846 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) BV122_847 ENOG4105E98 transcriptional regulator DeoR family BV122_848 ENOG4105D01 (LipO)protein BV122_85 ENOG4105K63 Thioredoxin BV122_851 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BV122_857 ENOG4105XCT Protein of unknown function (DUF2489) BV122_858 ENOG4105WH1 Two component transcriptional regulator luxr family BV122_859 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BV122_862 ENOG4105C9U ATP-dependent DNA helicase RecQ BV122_866 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase BV122_869 ENOG4105C8J )-transporter BV122_87 ENOG4105C5I Dehydrogenase BV122_872 ENOG4105C7B Threonine dehydratase BV122_873 ENOG4105C0B DNA polymerase III (alpha subunit) BV122_874 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain BV122_876 ENOG4107YZP Rhodanese domain protein BV122_877 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BV122_878 ENOG4105CEP NADH dehydrogenase BV122_88 ENOG4105C28 cystathionine BV122_882 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BV122_883 ENOG4105R3P Inner membrane protein yagU BV122_885 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BV122_886 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BV122_887 ENOG4105PXI polysaccharide deacetylase BV122_888 ENOG41063SB peptidase BV122_889 ENOG41063SB peptidase BV122_893 ENOG4105CEN a g-specific adenine glycosylase BV122_898 ENOG4108VVQ metallophosphoesterase BV122_899 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase BV122_9 ENOG4108MG3 formate dehydrogenase BV122_901 ENOG4105W1T Glycosyl Transferase BV122_902 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BV122_903 ENOG4106H78 methyltransferase BV122_904 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BV122_905 ENOG4105CAK Cell division ATP-binding protein ftsE BV122_906 ENOG4105CRP Part of the ABC transporter FtsEX involved in BV122_907 ENOG4105CHU acetyl-coa acetyltransferase BV122_908 ENOG4105CRW Short chain fatty acid transporter BV122_909 ENOG4107QNJ CoA-transferase subunit B BV122_910 ENOG4107QP7 CoA-transferase subunit A BV122_911 ENOG4105CMU LysR family (Transcriptional regulator BV122_917 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BV122_923 ENOG4108W2W BV122_924 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BV122_93 ENOG4105D98 threonine synthase BV122_932 ENOG4105VPB 50S ribosomal protein L30 BV122_934 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BV122_942 ENOG4105C4X radical SAM domain protein BV122_943 ENOG4105C4X radical SAM domain protein BV122_95 ENOG4105CFH Aspartokinase BV122_950 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BV122_953 ENOG4108M6U Universal stress protein A BV122_954 ENOG4107RAQ aminopeptidase BV122_956 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BV122_957 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BV122_958 ENOG4105F0Z galactose-1-phosphate uridylyltransferase BV122_959 ENOG41060NJ transcriptional regulator BV122_96 ENOG4105DFA alanine racemase domain protein BV122_960 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator BV122_962 ENOG4108HWV )-transporter BV122_965 ENOG4105NAU thioesterase Superfamily protein BV122_966 ENOG4105K9H YciI-like protein BV122_967 ENOG4107SC1 transglycosylase BV122_969 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase BV122_97 ENOG4105BZW Glycerate kinase BV122_970 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) BV122_971 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) BV122_972 ENOG4105E33 succinate dehydrogenase BV122_973 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) BV122_975 ENOG4105E3W Two component transcriptional regulator (Winged helix family BV122_976 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BV122_979 ENOG4105E68 Sulfatase BV122_98 ENOG4107QQ0 gntp family BV122_983 ENOG4108Z33 Thiol disulfide Interchange Protein BV122_984 ENOG4108WFC UPF0438 protein yifE BV122_987 ENOG4105WMJ Positive regulator of sigma E, RseC MucC BV122_988 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b BV122_989 ENOG4105C0R drug resistance transporter emrb qaca subfamily BV122_99 ENOG4107VHA regulatoR BV122_990 ENOG4105DEF Extracellular solute-binding protein, family 5 BV122_991 ENOG4108WHG pyridoxamine 5'-phosphate BV122_993 ENOG4105C2M dna polymerase I BV122_995 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BV122_996 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BV122_997 ENOG4105C2N RNA methyltransferase TrmH family group 3 BV122_998 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)