locus-tag class description CH621_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CH621_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CH621_00035 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CH621_00040 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CH621_00045 ENOG4105C79 DNA protecting protein DprA CH621_00050 ENOG4105D1Q UPF0246 protein CH621_00075 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CH621_00085 ENOG4105MZU cell filamentation protein CH621_00095 ENOG4108IA2 Sodium pantothenate symporter CH621_00100 ENOG4105RG0 Membrane CH621_00105 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CH621_00110 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CH621_00120 ENOG4105DNI Converts SHCHC to OSB (By similarity) CH621_00125 ENOG4108IPT Naphthoate synthase CH621_00150 ENOG4105CJR Integral membrane protein (MviN CH621_00155 ENOG4105DTN riboflavin biosynthesis protein ribF CH621_00165 ENOG4105K59 histidine triad (HIT) protein CH621_00175 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) CH621_00180 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) CH621_00185 ENOG4107RYR Transcriptional regulator, Crp Fnr family CH621_00205 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CH621_00225 ENOG4108JPW Aminotransferase CH621_00240 ENOG4105DY8 decarboxylase CH621_00250 ENOG4105C0H protease CH621_00255 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CH621_00265 ENOG4105DSY exodeoxyribonuclease V, gamma CH621_00290 ENOG4105ECY inositol monophosphatase CH621_00295 ENOG4105DA4 cytochrome c-type biogenesis protein CH621_00300 ENOG4107QX9 Thiol disulfide interChange protein CH621_00305 ENOG4108DMF Cytochrome C biogenesis protein CH621_00310 ENOG4105CBX hi0933 family CH621_00320 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) CH621_00330 ENOG4106032 Glutathionylspermidine synthase CH621_00335 ENOG4105CH6 catalase CH621_00345 ENOG41063VX Inherit from COG: glutaredoxin-related protein CH621_00350 ENOG4105WDY DNA (cytosine-5-)-methyltransferase CH621_00370 ENOG4105DJF DNA polymerase III, delta' subunit CH621_00385 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CH621_00390 ENOG4105KNE Phosphatidate cytidylyltransferase CH621_00395 ENOG4105DZP Membrane-associated zinc metalloprotease CH621_00400 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CH621_00425 ENOG4105DMQ Methyltransferase CH621_00430 ENOG4105CKD glutathione-regulated potassium-efflux system protein CH621_00435 ENOG4105M6F mutator MutT protein CH621_00440 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CH621_00455 ENOG4108Z6B deaminase CH621_00460 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CH621_00470 ENOG4105HF0 Membrane CH621_00485 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CH621_00490 ENOG4105CW7 secretion protein, HlyD family CH621_00495 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH621_00500 ENOG41063M6 Cell Division Protein CH621_00505 ENOG4105BZS acriflavin resistance protein CH621_00510 ENOG410624X efflux transporter, rnd family, mfp subunit CH621_00515 ENOG4105Y7M Transcriptional regulator, TetR family CH621_00545 ENOG4105C12 Phosphoribosylglycinamide synthetase CH621_00550 ENOG4105DC1 bifunctional purine biosynthesis protein purh CH621_00555 ENOG4105MGM doxx family CH621_00560 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) CH621_00565 ENOG41065U4 response regulator CH621_00570 ENOG4105BZG amino acid carrier protein CH621_00575 ENOG4105WPN DNA integration recombination invertion protein CH621_00580 ENOG4105EAH synthase CH621_00595 ENOG4105QYV Membrane CH621_00615 ENOG4105C1B dTDP-glucose 4-6-dehydratase CH621_00620 ENOG4105C5F glutamine synthetase CH621_00625 ENOG4105I85 Bifunctional alpha-2,3 -2,8-sialyltransferase CH621_00630 ENOG4105CI3 gtp-binding protein typa CH621_00640 ENOG4105EX9 Membrane CH621_00655 ENOG41068D6 Glycosyltransferase CH621_00665 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CH621_00670 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein CH621_00675 ENOG4108W0P ABC transporter CH621_00695 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CH621_00700 ENOG4105C2N RNA methyltransferase TrmH family group 3 CH621_00705 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CH621_00710 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CH621_00725 ENOG4105C2M dna polymerase I CH621_00735 ENOG4108WHG pyridoxamine 5'-phosphate CH621_00740 ENOG4105DEF Extracellular solute-binding protein, family 5 CH621_00745 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH621_00750 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b CH621_00760 ENOG4105WMJ Positive regulator of sigma E, RseC MucC CH621_00775 ENOG4108WFC UPF0438 protein yifE CH621_00780 ENOG4108Z33 Thiol disulfide Interchange Protein CH621_00800 ENOG4105E68 Sulfatase CH621_00815 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CH621_00820 ENOG4105E3W Two component transcriptional regulator (Winged helix family CH621_00830 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) CH621_00835 ENOG4105E33 succinate dehydrogenase CH621_00840 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) CH621_00845 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) CH621_00850 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase CH621_00860 ENOG4107SC1 transglycosylase CH621_00865 ENOG4105K9H YciI-like protein CH621_00870 ENOG4105NAU thioesterase Superfamily protein CH621_00885 ENOG4108HWV )-transporter CH621_00895 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator CH621_00900 ENOG41060NJ transcriptional regulator CH621_00905 ENOG4105F0Z galactose-1-phosphate uridylyltransferase CH621_00910 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CH621_00915 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CH621_00925 ENOG4107RAQ aminopeptidase CH621_00930 ENOG4108M6U Universal stress protein A CH621_00945 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CH621_01020 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CH621_01030 ENOG4105VPB 50S ribosomal protein L30 CH621_01070 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CH621_01075 ENOG4108W2W CH621_01105 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CH621_01135 ENOG4105CMU LysR family (Transcriptional regulator CH621_01140 ENOG4107QP7 CoA-transferase subunit A CH621_01145 ENOG4107QNJ CoA-transferase subunit B CH621_01150 ENOG4105CRW Short chain fatty acid transporter CH621_01155 ENOG4105CHU acetyl-coa acetyltransferase CH621_01160 ENOG4105CRP Part of the ABC transporter FtsEX involved in CH621_01165 ENOG4105CAK Cell division ATP-binding protein ftsE CH621_01170 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CH621_01175 ENOG4106H78 methyltransferase CH621_01180 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CH621_01195 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase CH621_01200 ENOG4108VVQ metallophosphoesterase CH621_01225 ENOG4105CEN a g-specific adenine glycosylase CH621_01240 ENOG41063SB peptidase CH621_01245 ENOG4105PXI polysaccharide deacetylase CH621_01270 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CH621_01290 ENOG4105CEP NADH dehydrogenase CH621_01295 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CH621_01300 ENOG4107YZP Rhodanese domain protein CH621_01310 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain CH621_01315 ENOG4105C0B DNA polymerase III (alpha subunit) CH621_01320 ENOG4105C7B Threonine dehydratase CH621_01340 ENOG4105C8J )-transporter CH621_01355 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase CH621_01375 ENOG4105C9U ATP-dependent DNA helicase RecQ CH621_01390 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CH621_01395 ENOG4105WH1 Two component transcriptional regulator luxr family CH621_01400 ENOG4105XCT Protein of unknown function (DUF2489) CH621_01435 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CH621_01450 ENOG4105D01 (LipO)protein CH621_01455 ENOG4105E98 transcriptional regulator DeoR family CH621_01460 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) CH621_01465 ENOG4105D3G Pseudouridine synthase CH621_01475 ENOG4107EDW L-fucose operon activator CH621_01480 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) CH621_01485 ENOG4105CMG Carbohydrate kinase CH621_01495 ENOG4107W7X Aldolase CH621_01520 ENOG4105C8P )-transporter CH621_01525 ENOG4105F9E Shikimate 5-dehydrogenase CH621_01530 ENOG4105D7W serine acetyltransferase CH621_01540 ENOG4107T0K Adenylate cyclase CH621_01545 ENOG4105ECF c-methyltransferase CH621_01550 ENOG410601J HemY protein CH621_01600 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) CH621_01605 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CH621_01620 ENOG4105KME endoribonuclease L-psp CH621_01625 ENOG410903C (LipO)protein CH621_01630 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CH621_01635 ENOG4105PM1 preprotein translocase subunit SecE CH621_01640 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CH621_01670 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) CH621_01680 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CH621_01685 ENOG4105CIC tryptophan-specific transport protein CH621_01700 ENOG4108K5P (LipO)protein CH621_01710 ENOG4108UM1 dedA family CH621_01725 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) CH621_01730 ENOG4108YZY peptidylprolyl cis-trans isomerase CH621_01735 ENOG4105CFU surface antigen CH621_01740 ENOG4105MA0 exported protein CH621_01745 ENOG4105C9X ppx gppa phosphatase CH621_01750 ENOG4108R99 pseudouridine synthase CH621_01755 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family CH621_01760 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase CH621_01780 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase CH621_01785 ENOG4105CXY transporter CH621_01790 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A CH621_01800 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CH621_01810 ENOG4105EMY transcriptional regulator CH621_01815 ENOG4105DTR rard protein CH621_01830 ENOG4108HYK gCN5-related N-acetyltransferase CH621_01840 ENOG4105CIN aminoacyl-histidine dipeptidase CH621_01870 ENOG4105QTB Flavodoxin CH621_01880 ENOG4105CBT Fructose-1,6-bisphosphatase CH621_01885 ENOG4105BZ1 (ABC) transporter CH621_01890 ENOG4108JJ9 ABC, transporter CH621_01905 ENOG4105C5H ABC transporter CH621_01910 ENOG4108WI1 Dna topoisomerase CH621_01915 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CH621_01930 ENOG4108R3E Dna-3-methyladenine glycosylase i CH621_01935 ENOG4106WTF Glycosyl transferase, family 2 CH621_01940 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase CH621_01955 ENOG4105C4R Atp-dependent dna helicase CH621_01960 ENOG4105HEI LysR family (Transcriptional regulator CH621_01965 ENOG4105NF4 modulator of drug activity CH621_01970 ENOG4105KT7 mgtC SapB transporter CH621_01975 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CH621_01980 ENOG4108EUD Lysophospholipase CH621_01985 ENOG4105CUW cytochrome C-TYPE protein CH621_01990 ENOG4107QY8 reductase CH621_02030 ENOG4107QTF adenylosuccinate lyase CH621_02040 ENOG4105C31 Tryptophanyl-tRNA synthetase CH621_02045 ENOG4105KZW UPF0381 protein CH621_02050 ENOG4108MVK Receptor CH621_02060 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CH621_02095 ENOG4105CS9 pantothenic acid kinase CH621_02100 ENOG4105VQK sigma E regulatory protein, MucB RseB CH621_02105 ENOG41069PW sigma-e factor negative regulatory protein CH621_02110 ENOG4105EMN RNA polymerase sigma factor CH621_02115 ENOG4105Y75 tpr repeat protein CH621_02125 ENOG4105C1A potassium transporter peripheral membrane CH621_02130 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CH621_02135 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CH621_02195 ENOG4105DQF Hydrolase CH621_02200 ENOG4105DBV ornithine carbamoyltransferase CH621_02205 ENOG4105C5B carbamate kinase CH621_02210 ENOG4105CSX c4-dicarboxylate anaerobic carrier CH621_02250 ENOG4105CH2 amidohydrolase CH621_02255 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic CH621_02260 ENOG4105W1Y Transcriptional regulator CH621_02265 ENOG4105PGM cation diffusion facilitator family transporter CH621_02275 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CH621_02300 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) CH621_02305 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) CH621_02310 ENOG4105WWK YheO domain protein CH621_02315 ENOG4108V1T peptidylprolyl cis-trans isomerase CH621_02325 ENOG4105EHV domain protein CH621_02330 ENOG4105C5Q Transcriptional regulator CH621_02335 ENOG4105EJ2 Transcriptional regulator CH621_02340 ENOG4108RRZ Transcription elongation factor GreB CH621_02345 ENOG4105BZM domain protein CH621_02350 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH621_02355 ENOG4105DJV ribulose-phosphate 3-epimerase CH621_02360 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CH621_02365 ENOG4105CU9 asparagine synthetase A CH621_02370 ENOG4108VVK transcriptional Regulator, AsnC CH621_02375 ENOG4105VEJ Heat shock protein CH621_02380 ENOG4105EPD Oligopeptide transporter, Opt family CH621_02395 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CH621_02405 ENOG41090HT Inherit from COG: transposase CH621_02410 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CH621_02415 ENOG4105WV0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) CH621_02520 ENOG4108IJ0 Aspartate ammonia-lyase CH621_02525 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CH621_02530 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CH621_02540 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CH621_02550 ENOG4105E0U tyrosine-specific transport protein CH621_02555 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding CH621_02560 ENOG41083KI ribonuclease, T2 CH621_02570 ENOG4105D2N Aldolase CH621_02575 ENOG4105M5K heptosyltransferase CH621_02580 ENOG4108VW9 Membrane CH621_02585 ENOG4105G0K glycine radical enzyme YjjI family CH621_02590 ENOG41076CZ activating enzyme CH621_02595 ENOG4105D9N nucleoside CH621_02640 ENOG4108R96 Methyltransferase, YaeB family CH621_02645 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CH621_02660 ENOG4105ETE Transcriptional regulator (LacI family CH621_02665 ENOG4108RVA ribokinase CH621_02670 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CH621_02675 ENOG4105CNN ABC, transporter CH621_02690 ENOG4105CGY Dna recombination protein CH621_02695 ENOG4105CJP fad dependent oxidoreductase CH621_02700 ENOG4107RUE extracellular solute-binding protein family 1 CH621_02715 ENOG4105F0S class B acid phosphatase CH621_02730 ENOG4105W39 Membrane CH621_02735 ENOG4107VXZ Hydrolase CH621_02795 ENOG4105E0U tyrosine-specific transport protein CH621_02805 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CH621_02830 ENOG4105CIH Imidazole acetol-phosphate transaminase CH621_02845 ENOG4105DSJ YicC domain protein CH621_02850 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CH621_02855 ENOG4108JQ1 Dehydrogenase CH621_02860 ENOG4105E66 phosphoriboisomerase A CH621_02865 ENOG4105CSA Coproporphyrinogen iii oxidase CH621_02870 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CH621_02875 ENOG4108MJ5 VirK protein CH621_02880 ENOG4105DXN mazG family CH621_02890 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) CH621_02895 ENOG4105HHA aminodeoxychorismate lyase CH621_02910 ENOG4107QRG dna polymerase iii CH621_02915 ENOG4105F8V Hydrolase, tatD family CH621_02920 ENOG4105RX8 Protein of unknown function (DUF1523) CH621_02925 ENOG4105C37 (CBS) domain CH621_02930 ENOG41063ES CH621_02935 ENOG4105K60 Virulence-associated protein D CH621_02945 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CH621_02950 ENOG4105DE4 1-phosphofructokinase CH621_02955 ENOG4105DM4 PTS System CH621_02970 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CH621_02980 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CH621_02985 ENOG4105D6S protein involved in catabolism of external DNA CH621_02990 ENOG4108JQC penicillin-binding protein 1A CH621_03015 ENOG4105E4G Type IV pilus CH621_03020 ENOG4105MJ2 Competence protein CH621_03035 ENOG4105R2J Conserved Protein CH621_03040 ENOG4105K70 DNA-binding protein CH621_03045 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CH621_03055 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CH621_03065 ENOG4105JIM Phosphatidylserine synthase CH621_03070 ENOG4105EIB trna rrna methyltransferase CH621_03080 ENOG4105C1J atp-dependent rna helicase CH621_03085 ENOG4105CFP Peptidase U32 CH621_03090 ENOG4105CSH Transporter CH621_03100 ENOG4105DWF phosphomethylpyrimidine kinase CH621_03115 ENOG4105C03 ribonuclease CH621_03120 ENOG4105EI2 Pseudouridine synthase CH621_03125 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CH621_03130 ENOG4108JU8 Transcriptional regulator CH621_03135 ENOG4105DR5 peptidase CH621_03140 ENOG4105FDK ABC transporter CH621_03145 ENOG4105FAV ABC, transporter CH621_03150 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CH621_03155 ENOG4107G57 functions in a salvage pathway. Uses pyridoxamine (By similarity) CH621_03170 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CH621_03180 ENOG4105KZW UPF0381 protein CH621_03185 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) CH621_03190 ENOG41087AY ADP-Ribose pyrophosphatase CH621_03200 ENOG4105EZE Cupin 4 family protein CH621_03215 ENOG4105C3G gtp-binding protein CH621_03225 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) CH621_03230 ENOG4105CEY Amp-dependent synthetase and ligase CH621_03235 ENOG4105R8X Outer membrane lipoprotein Slp CH621_03240 ENOG41072GX Peptidase M22 Glycoprotease CH621_03245 ENOG4105DVT helicase CH621_03250 ENOG4107YD3 Thioesterase CH621_03255 ENOG4105E02 MotA TolQ exbB proton channel CH621_03275 ENOG4105KCK Peptidoglycan-associated lipoprotein CH621_03320 ENOG4107V6I Cytosine-specific methyltransferase CH621_03320 ENOG4107V6I Cytosine-specific methyltransferase CH621_03355 ENOG4108PNI recT protein CH621_03370 ENOG4105CEC DNA methylase N-4 N-6 CH621_03400 ENOG4107EPN Domain of unknown function (DUF1508) CH621_03420 ENOG4105XB7 anti-repressor protein CH621_03500 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CH621_03570 ENOG4105WXW Antirepressor CH621_03615 ENOG4105CVS RNA methyltransferase TrmH family, group 1 CH621_03630 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins CH621_03635 ENOG4108Z4V iron-sulfur cluster assembly CH621_03640 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) CH621_03645 ENOG4108RF1 Protein of unknown function DUF2625 CH621_03650 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB CH621_03655 ENOG4108ZIT Ferredoxin, 2FE-2S CH621_03660 ENOG4105WVQ Fe-S assembly protein IscX CH621_03665 ENOG4105N21 Membrane CH621_03675 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CH621_03680 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) CH621_03685 ENOG41090FY type IV pilus biogenesis stability protein PilW CH621_03695 ENOG41061WM D-Alanyl-D-Alanine CH621_03710 ENOG4105DIK (ABC) transporter CH621_03715 ENOG4105CC5 ABC transporter CH621_03720 ENOG4105CC5 ABC transporter CH621_03725 ENOG4105ETU transcriptional activator (TenA CH621_03730 ENOG4107Z6I Thiamine biosynthesis protein CH621_03735 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component CH621_03740 ENOG4108YI8 ABC transporter CH621_03745 ENOG4105I85 Bifunctional alpha-2,3 -2,8-sialyltransferase CH621_03750 ENOG4105CMR udp-glucose 4-epimerase CH621_03755 ENOG4105EYM Major Facilitator superfamily CH621_03765 ENOG4105CUW cytochrome C-TYPE protein CH621_03770 ENOG4105IYZ Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) CH621_03775 ENOG4105GXZ Ferredoxin-type protein NapH CH621_03780 ENOG4108BGM Quinol dehydrogenase periplasmic component CH621_03800 ENOG41090ED Protein with unknown function (DUF469) CH621_03810 ENOG4105C25 Primosomal protein n' CH621_03815 ENOG4105DSF transport protein CH621_03820 ENOG4108YZA Nitrogen regulatory protein pii CH621_03825 ENOG4108RIR Molybdenum cofactor biosynthesis protein CH621_03830 ENOG41080IJ Diacylglycerol kinase CH621_03835 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CH621_03840 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CH621_03845 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) CH621_03855 ENOG4108UBT opacity-associated protein CH621_03860 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CH621_03880 ENOG4105D3Y Na H antiporter CH621_03890 ENOG4108UYE Lactoylglutathione lyase CH621_03910 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase CH621_03915 ENOG4105C9M aspartyl-trna synthetase CH621_03920 ENOG4108TIT dATP pyrophosphohydrolase CH621_03950 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CH621_03955 ENOG4105D8G Major Facilitator superfamily CH621_03960 ENOG4105II7 pyrroline-5-carboxylate reductase CH621_03995 ENOG4105DFP Integrase CH621_04015 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CH621_04020 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) CH621_04025 ENOG4108JU5 Magnesium and cobalt efflux protein CH621_04030 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CH621_04040 ENOG4107QHF type ii secretion system protein e CH621_04045 ENOG4105D7Q type ii secretion system CH621_04055 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CH621_04065 ENOG4108Z6Z Transcriptional regulator CH621_04080 ENOG4105C59 p-type ATPase CH621_04085 ENOG4105C44 Serine transporter CH621_04090 ENOG4105EJQ L-serine dehydratase CH621_04095 ENOG4105CIC tryptophan-specific transport protein CH621_04100 ENOG4105CHM Aminotransferase CH621_04110 ENOG4105E4F Isochorismate synthase CH621_04120 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CH621_04125 ENOG4105CSH Transporter CH621_04130 ENOG4108I5U Uridine phosphorylase CH621_04150 ENOG4107T7U Sulfatase CH621_04195 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) CH621_04205 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CH621_04225 ENOG4107ZVW dihydroneopterin aldolase CH621_04230 ENOG4105IB0 filamentous hemagglutinin family outer membrane protein CH621_04235 ENOG4108D1Y Polypeptide-transport-associated domain protein, ShlB-type CH621_04245 ENOG4105DKP glycosyl transferase, family 9 CH621_04250 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) CH621_04255 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CH621_04265 ENOG4105X1N Glycosyl transferase family 8 CH621_04275 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA CH621_04290 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CH621_04295 ENOG4105M8K biopolymer transport protein CH621_04300 ENOG4105M15 transport protein ExbD CH621_04305 ENOG4108DNJ Pfam:TonB CH621_04310 ENOG4108UUM single-stranded DNA-binding protein CH621_04315 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CH621_04335 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CH621_04340 ENOG4105NSG hemerythrin hhe cation binding domain protein CH621_04350 ENOG4105VIE preprotein translocase, subunit YajC CH621_04355 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CH621_04360 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CH621_04370 ENOG4105K89 arsenate reductase CH621_04390 ENOG4105C1J atp-dependent rna helicase CH621_04395 ENOG4105RT1 May be involved in cell division (By similarity) CH621_04410 ENOG4108R66 Conserved Protein CH621_04415 ENOG4105CWM branched-chain amino acid transport system II carrier protein CH621_04425 ENOG4105FKN transcriptional regulator, AsnC family CH621_04430 ENOG4106KPZ rard protein CH621_04440 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CH621_04445 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CH621_04470 ENOG4108RG0 uracil-dna glycosylase CH621_04480 ENOG4108KBJ Inner membrane protein YkgB CH621_04500 ENOG41082EK Restriction modification system DNA (Specificity CH621_04510 ENOG4105DGW oligopeptidase A CH621_04515 ENOG4105WD1 Membrane CH621_04520 ENOG4107TSG Extracellular solute-binding protein, family 5 CH621_04530 ENOG4105EYK Phosphatidylglycerophosphatase B CH621_04535 ENOG4105DFE Dna adenine methylase CH621_04550 ENOG4105CGH 5'-nucleotidase CH621_04555 ENOG4106W3N CH621_04585 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase CH621_04590 ENOG4105EJ9 Membrane CH621_04595 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) CH621_04605 ENOG4105EGS Mechanosensitive ion channel CH621_04610 ENOG4105CEY Amp-dependent synthetase and ligase CH621_04615 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) CH621_04620 ENOG4105EV9 Alpha Beta Hydrolase CH621_04625 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) CH621_04630 ENOG41090R7 Ferric uptake CH621_04635 ENOG4105D82 Glutamate dehydrogenase CH621_04640 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CH621_04655 ENOG4105VUF Transcriptional regulator CH621_04660 ENOG4107QPD alcohol dehydrogenase CH621_04665 ENOG4105C4W S-formylglutathione hydrolase CH621_04670 ENOG4105BZG amino acid carrier protein CH621_04680 ENOG4105TMB Formate nitrite transporter CH621_04685 ENOG4105C6N Formate acetyltransferase CH621_04690 ENOG4105F1A Pyruvate formate-lyase CH621_04700 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CH621_04705 ENOG4105C34 Pseudouridine synthase CH621_04710 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CH621_04725 ENOG4105CJ2 (LipO)protein CH621_04745 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CH621_04765 ENOG4105IEY (LipO)protein CH621_04770 ENOG4105DC8 reductase CH621_04775 ENOG4105DJ4 phosphatidylserine decarboxylase CH621_04780 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein CH621_04785 ENOG4105VGS 50s ribosomal protein l32 CH621_04800 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CH621_04805 ENOG4105CHR reductase CH621_04815 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CH621_04825 ENOG4107QJR hflk protein CH621_04830 ENOG4105EPW hflc protein CH621_04845 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH621_04855 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) CH621_04865 ENOG4105QEK Transcriptional regulator CH621_04870 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CH621_04880 ENOG4105CE4 GlcNAc 6-P deacetylase CH621_04895 ENOG4107RZZ dna polymerase iii epsilon subunit CH621_04910 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CH621_04915 ENOG4105F27 Major Facilitator CH621_04935 ENOG4105C7N Xanthine uracil vitamin C permease CH621_04940 ENOG4105F0N pyrophosphate phospho-hydrolase CH621_04960 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CH621_04965 ENOG4105C28 cystathionine CH621_04975 ENOG4105DFU Cell wall formation (By similarity) CH621_04985 ENOG4105NXV High-affinity zinc uptake system protein CH621_04990 ENOG4105CUZ uba thif-type nad fad binding protein CH621_04995 ENOG4105CA3 membrane-bound lytic murein transglycosylase CH621_05055 ENOG4108K3A Glutathione S-transferase CH621_05070 ENOG4107XM3 UPF0442 protein CH621_05075 ENOG4107XM3 UPF0442 protein CH621_05080 ENOG4108JU6 CBS domain protein CH621_05085 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY CH621_05110 ENOG4105HVQ Regulatory factor of maltose metabolism CH621_05115 ENOG4106YXT transposase CH621_05120 ENOG4108WTW DNA transposition protein CH621_05130 ENOG4105IKI host-nuclease inhibitor protein CH621_05150 ENOG4105ZIA Phage protein gp16 CH621_05330 ENOG4107H6E CH621_05350 ENOG4105CVR type I restriction-modification system CH621_05355 ENOG4107QNR UPF0135 protein CH621_05360 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CH621_05365 ENOG4105KUZ arsenate reductase CH621_05380 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CH621_05385 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component CH621_05390 ENOG4107QKW extracellular solute-binding protein family 1 CH621_05400 ENOG4105DFA alanine racemase domain protein CH621_05405 ENOG4105CFH Aspartokinase CH621_05415 ENOG4105D98 threonine synthase CH621_05440 ENOG4105C28 cystathionine CH621_05445 ENOG4105C5I Dehydrogenase CH621_05450 ENOG4105K63 Thioredoxin CH621_05460 ENOG4105EYA deoxyribonuclease CH621_05465 ENOG4105UIH PemK-like protein CH621_05470 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CH621_05480 ENOG4105C29 acyl-CoA thioesterase CH621_05485 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CH621_05490 ENOG41062MS nucleotidyltransferase substrate binding protein CH621_05495 ENOG41060A7 DNA polymerase beta domain protein region CH621_05500 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CH621_05510 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CH621_05515 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) CH621_05530 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CH621_05535 ENOG4105K8N protein family UPF0079, ATPase CH621_05540 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CH621_05545 ENOG4105DJ0 Poly(A) Polymerase CH621_05550 ENOG4105SVQ Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression (By similarity) CH621_05555 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 CH621_05560 ENOG4105BZ1 (ABC) transporter CH621_05565 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) CH621_05580 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CH621_05585 ENOG4105EE5 Membrane protein terC CH621_05595 ENOG4107YCY Transcriptional regulator CH621_05600 ENOG4105CPQ Dehydrogenase CH621_05605 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit CH621_05610 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter CH621_05615 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH621_05620 ENOG4107SS6 2-dehydro-3-deoxygluconokinase CH621_05625 ENOG4105DMW Dehydrogenase reductase CH621_05630 ENOG4108UHU Aldolase CH621_05635 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CH621_05640 ENOG4108UUE Transcriptional regulator CH621_05650 ENOG4108MN8 Membrane CH621_05660 ENOG4108W1A pseudouridine synthase CH621_05665 ENOG4105CGK Exodeoxyribonuclease III CH621_05670 ENOG4105GXY Family of unknown function (DUF695) CH621_05680 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CH621_05685 ENOG4105DFF Rod shape-determining protein mreb CH621_05690 ENOG4105CQ0 ABC transporter CH621_05695 ENOG4105D0C transport protein CH621_05700 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) CH621_05710 ENOG4105CJN penicillin-binding protein CH621_05715 ENOG4105CNI cell division protein FtsW CH621_05720 ENOG4105K6T rare lipoprotein A CH621_05725 ENOG4105DZ1 carboxypeptidase CH621_05730 ENOG4108D64 Protein of unknown function (DUF493) CH621_05745 ENOG4105DUA (citrate (pro-3S)-lyase ligase CH621_05755 ENOG4105CI0 Citrate lyase CH621_05760 ENOG4105CHY citrate lyase, alpha CH621_05765 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase CH621_05770 ENOG4107QPK )-transporter CH621_05795 ENOG4105C3F Signal peptidase i CH621_05800 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CH621_05815 ENOG4108WPU DNA polymerase III subunit psi CH621_05820 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CH621_05830 ENOG4108MG3 formate dehydrogenase CH621_05835 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CH621_05850 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CH621_05860 ENOG410667J hydrolase CH621_05865 ENOG4108IQE Amp-dependent synthetase and ligase CH621_05870 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CH621_05885 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CH621_05890 ENOG4105CB5 ATP-dependent DNA helicase recG CH621_05930 ENOG4105DZ2 Transcriptional regulator CH621_05935 ENOG4108UMN azlc family CH621_05940 ENOG4105KMT branched-chain amino acid CH621_05945 ENOG4106CC8 Bacterial inner membrane protein CH621_05955 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CH621_05965 ENOG4105P4J Allophanate hydrolase, subunit 1 CH621_05970 ENOG4107R7A Allophanate hydrolase subunit 2 CH621_05980 ENOG4105C5A transporter CH621_05995 ENOG4105BZ4 penicillin-binding protein CH621_06000 ENOG4108ZIG UPF0231 protein CH621_06010 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CH621_06020 ENOG4105ESV Glycosyl transferase, family 4 CH621_06040 ENOG4105KZ7 phosphocarrier protein hpr CH621_06045 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CH621_06050 ENOG4105C5Y PTS System CH621_06060 ENOG4105WXI Bacterial OB fold (BOF) protein CH621_06070 ENOG4105DHQ Histidine kinase CH621_06075 ENOG4105C94 Transporter CH621_06085 ENOG4108M8S permease YjgP YjgQ family protein CH621_06090 ENOG4108K5H permease YjgP YjgQ family protein CH621_06100 ENOG41080C8 DUF218 domain CH621_06105 ENOG4108MY6 biosynthesis protein CH621_06110 ENOG4105P7J Transfers sialic acid from the substrate CMP-sialic acid donor to the terminal beta-D-galactosyl-1,4-acetyl-beta-D- glucosamine on the lacto-N-neotetraose branch of the lipooligosaccharide CH621_06115 ENOG4105CG5 Glycosyl transferase (Group 1 CH621_06120 ENOG41068D6 Glycosyltransferase CH621_06125 ENOG4108RJ9 Glycosyl transferase, family 2 CH621_06130 ENOG4108RYC glycosyltransferase CH621_06135 ENOG4105F4R Transcriptional regulator mode CH621_06140 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CH621_06145 ENOG4105E0C molybdate abc transporter CH621_06155 ENOG4105C8J )-transporter CH621_06160 ENOG4105CSM endonuclease III CH621_06180 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) CH621_06180 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) CH621_06190 ENOG4105DGN Electron transport complex CH621_06200 ENOG4105ERU peptidase CH621_06210 ENOG4105EM2 membrane CH621_06215 ENOG4106YJS accessory processing protein CH621_06230 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase CH621_06235 ENOG4105C2X Arabinose 5-phosphate isomerase CH621_06245 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) CH621_06260 ENOG4105M00 molybdopterin converting factor, subunit 1 CH621_06265 ENOG4108ZAF Molybdopterin CH621_06270 ENOG4105DY2 Paraquat-inducible protein b CH621_06275 ENOG4105H2K paraquat-inducible protein a CH621_06285 ENOG4105CN1 protease CH621_06290 ENOG4105DIT ErfK YbiS YcfS YnhG family protein CH621_06300 ENOG4108RE7 deoxyribonuclease CH621_06305 ENOG4105C5X domain protein CH621_06310 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CH621_06315 ENOG4105C7S Dehydrogenase CH621_06320 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CH621_06325 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CH621_06330 ENOG4105W4M Transport-associated protein CH621_06335 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CH621_06345 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) CH621_06350 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CH621_06355 ENOG4105D1U peptidase U62 modulator of DNA gyrase CH621_06360 ENOG4107TT5 NLP P60 protein CH621_06380 ENOG4105CXG d-lactate dehydrogenase CH621_06395 ENOG4105CAT Cytidine monophosphate kinase CH621_06400 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CH621_06410 ENOG4105Q4A inner membrane protein yciS CH621_06415 ENOG4105CFV Tetratricopeptide repeat protein CH621_06425 ENOG4108ZJT translation initiation factor, Sui1 CH621_06430 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) CH621_06435 ENOG4105C2W permease CH621_06445 ENOG4107QMP dna polymerase iii subunits gamma and tau CH621_06455 ENOG4107QN2 dihydrolipoyl dehydrogenase CH621_06460 ENOG4107QSN dihydrolipoamide acetyltransferase CH621_06465 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CH621_06495 ENOG4105EN6 Membrane CH621_06505 ENOG4105C2C drug resistance transporter, Bcr CflA CH621_06510 ENOG4105I08 Pseudouridine synthase CH621_06515 ENOG4105TWJ Domain of unknown function (DUF1919) CH621_06520 ENOG4105C6K Malic enzyme CH621_06525 ENOG4105E0M Sulfatase CH621_06540 ENOG4105D7X high-affinity nickel-transporter CH621_06545 ENOG41065CD Exported protein CH621_06550 ENOG41080ET plasmid maintenance system killer protein CH621_06555 ENOG4105VDM plasmid maintenance system antidote protein, xre family CH621_06560 ENOG4105C5H ABC transporter CH621_06575 ENOG4108JA2 transcriptioN-repair coupling factor CH621_06580 ENOG4105C0H protease CH621_06590 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CH621_06595 ENOG4107GZ4 SanA protein CH621_06605 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH621_06615 ENOG4105DDY UPF0142 protein ycaO CH621_06620 ENOG4106ZKY CH621_06630 ENOG4105EHG Permease protein CH621_06640 ENOG4108BSC Methyltransferase CH621_06645 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CH621_06660 ENOG4105D1F ATP-binding protein CH621_06665 ENOG4108RCM Nitroreductase CH621_06670 ENOG4105F0R Cytidylyltransferase CH621_06720 ENOG4105KUS lysozyme CH621_06870 ENOG4105CHV Transcription elongation factor NusA CH621_06875 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CH621_06880 ENOG4105DZR Type I site-specific deoxyribonuclease CH621_06890 ENOG4105EKX Restriction modification system DNA (Specificity CH621_06895 ENOG4105CVR type I restriction-modification system CH621_06910 ENOG4105EHE chorismate mutase- prephenate dehydrogenase CH621_06920 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein CH621_06925 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) CH621_06930 ENOG4105C9B Cysteine desulfurase CH621_06935 ENOG4105KK6 nuclease CH621_06945 ENOG41067MG lrgb family CH621_06955 ENOG4105C5H ABC transporter CH621_06960 ENOG4107RUE extracellular solute-binding protein family 1 CH621_06965 ENOG4105D38 putrescine abc transporter CH621_06970 ENOG4105F38 ABC transporter, permease CH621_06975 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CH621_06985 ENOG4108RMU ferritin dps family protein CH621_07000 ENOG4105CK7 Sodium proline symporter CH621_07005 ENOG4105C03 ribonuclease CH621_07020 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) CH621_07030 ENOG4108ESZ Glycogen debranching enzyme CH621_07045 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CH621_07050 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CH621_07055 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CH621_07060 ENOG4105CC0 LysR family Transcriptional regulator CH621_07065 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CH621_07075 ENOG4105C22 threonyL-tRNA synthetase CH621_07080 ENOG4107RAN Peptidase, M16 CH621_07090 ENOG4105X1Q TOBE domain protein CH621_07095 ENOG4108Z0T Part of a sulfur-relay system (By similarity) CH621_07100 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) CH621_07105 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) CH621_07120 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) CH621_07130 ENOG4108HFV CH621_07135 ENOG4108TZV Membrane CH621_07140 ENOG4105CJB Exodeoxyribonuclease I CH621_07145 ENOG4105BZU Histidine kinase CH621_07150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CH621_07160 ENOG4105E2Z phosphate ABC transporter (Permease CH621_07165 ENOG4105C8U phosphate abc transporter CH621_07170 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) CH621_07175 ENOG41090A1 ferritin CH621_07180 ENOG41090A1 ferritin CH621_07190 ENOG4105CRQ synthase (Component I) CH621_07195 ENOG4105DDQ anthranilate synthase CH621_07200 ENOG4108V5Q transglutaminase-like protein CH621_07210 ENOG4105DK0 Indole-3-glycerol phosphate synthase CH621_07215 ENOG41082MF Hydrogenase assembly chaperone hypC hupF CH621_07220 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CH621_07245 ENOG4105MYG DNA polymerase iii, chi subunit CH621_07250 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CH621_07255 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CH621_07265 ENOG4105C9Q fumarate hydratase class II CH621_07270 ENOG4105RHG CH621_07275 ENOG4105DB7 PHP domain protein CH621_07285 ENOG41090AG Bacteriophage protein CH621_07290 ENOG4108C66 Inherit from COG: DNA primase CH621_07295 ENOG4107ZQ5 Phage-associated protein, HI1409 family CH621_07300 ENOG4108N0N Phage Terminase Large Subunit CH621_07305 ENOG41061CV Terminase small subunit CH621_07325 ENOG4105NVB glycoside hydrolase, family 19 CH621_07335 ENOG4105WXW Antirepressor CH621_07440 ENOG4105XB7 anti-repressor protein CH621_07455 ENOG4105DS0 Transcriptional regulator, Crp Fnr family CH621_07460 ENOG4105Q9Y Universal stress protein CH621_07470 ENOG4108V3E phosphoribosylglycinamide formyltransferase CH621_07480 ENOG4105EMU Dehydrogenase CH621_07495 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CH621_07500 ENOG4108Z66 YbaK ebsC protein CH621_07505 ENOG4105VEQ Cold shock protein CH621_07520 ENOG4105WP7 tRNA pseudouridine synthase C CH621_07535 ENOG4105CTB Polyprenyl synthetase CH621_07545 ENOG4105KB2 stringent starvation protein b CH621_07550 ENOG4107MKT Stringent starvation protein a CH621_07565 ENOG4105SYT Methylenetetrahydrofolate reductase CH621_07570 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CH621_07580 ENOG4105EUJ GTP cyclohydrolase i CH621_07585 ENOG4105CVM Molybdenum cofactor synthesis domain protein CH621_07590 ENOG4105D06 uba thif-type nad fad binding protein CH621_07595 ENOG4105XW2 UPF0263 protein CH621_07600 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CH621_07605 ENOG4107QIV Cytochrome c biogenesis protein CH621_07610 ENOG4105E0X reductase CH621_07625 ENOG4108WQI RNA Polymerase CH621_07645 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CH621_07650 ENOG4106DNW CH621_07655 ENOG4108BY2 phosphohistidine phosphatase CH621_07665 ENOG4105EEI dihydropteroate synthase CH621_07670 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CH621_07675 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) CH621_07680 ENOG4105HBR Rna-binding protein CH621_07685 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CH621_07690 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase CH621_07710 ENOG4105XTM Inherit from NOG: Mn2 dependent serine threonine protein kinase CH621_07720 ENOG4105DAN ATP-dependent protease CH621_07730 ENOG4107QYX exodeoxyribonuclease v alpha CH621_07735 ENOG4107QKA exodeoxyribonuclease V beta CH621_07740 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CH621_07745 ENOG41082NX 50s ribosomal protein l35 CH621_07750 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CH621_07755 ENOG4105DSB aldose 1-epimerase CH621_07765 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CH621_07775 ENOG4108ZF3 Phosphatase CH621_07780 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CH621_07785 ENOG4105CNU cell division protein FtsK CH621_07795 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CH621_07810 ENOG4108QBX (LipO)protein CH621_07830 ENOG4106HX4 CH621_07835 ENOG4105XPH Ferredoxin CH621_07845 ENOG4105CCF Lysine exporter protein (Lyse ygga) CH621_07850 ENOG4108ZAI phosphatidylglycerophosphatase a CH621_07855 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CH621_07875 ENOG41077A9 carbonic anhydrase CH621_07880 ENOG4105C5H ABC transporter CH621_07885 ENOG4105C5H ABC transporter CH621_07890 ENOG4105C5H ABC transporter CH621_07910 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) CH621_07915 ENOG4105D1S lipid A biosynthesis CH621_07920 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH621_07925 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH621_07930 ENOG4105D6U Sodium Glutamate Symporter CH621_07940 ENOG41090BQ Glutaredoxin CH621_07945 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH621_07950 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) CH621_07960 ENOG4108KN0 Choline kinase CH621_07965 ENOG4106MCE EamA-like transporter family CH621_07975 ENOG4105KPE licD family CH621_07980 ENOG4105D07 Signal peptide peptidase, SppA CH621_07985 ENOG41069NU Nitroreductase CH621_07990 ENOG4107XHZ cytoplasmic chaperone TorD family protein CH621_07995 ENOG4105DYS nad(p)h dehydrogenase (quinone) CH621_08010 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CH621_08015 ENOG4105D60 lipoprotein releasing system transmembrane protein CH621_08025 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CH621_08030 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CH621_08035 ENOG4105HSA Protein of unknown function (DUF452) CH621_08045 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CH621_08050 ENOG4105D60 lipoprotein releasing system transmembrane protein CH621_08055 ENOG4105C5I Dehydrogenase CH621_08065 ENOG41063JG Transcriptional regulator CH621_08070 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CH621_08085 ENOG4108UQD Sel1 domain protein repeat-containing protein CH621_08090 ENOG4108UQD Sel1 domain protein repeat-containing protein CH621_08095 ENOG41082ND Uncharacterized protein yjcO CH621_08100 ENOG4108BPE -transporting atpase CH621_08130 ENOG4105CA9 Pyruvate kinase CH621_08135 ENOG4105CDU Replicative dna helicase CH621_08140 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CH621_08155 ENOG4107S6X Glycosyl transferase, family 2 CH621_08160 ENOG4108XTF Outer Membrane Lipoprotein CH621_08170 ENOG4105NBI YecM protein CH621_08180 ENOG4108ZP8 Acetolactate synthase small subunit CH621_08185 ENOG4105C7K acetolactate synthase CH621_08195 ENOG4107S6Z Na H antiporter CH621_08200 ENOG4108SAU DNA-binding protein H-ns CH621_08205 ENOG4105CIY formyltetrahydrofolate deformylase CH621_08215 ENOG4105D1H recombination factor protein RarA CH621_08230 ENOG4105EW9 transcriptional regulator AsnC family CH621_08235 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CH621_08240 ENOG4105I7R Adenylate cyclase CH621_08255 ENOG4106YJS accessory processing protein CH621_08295 ENOG4105E18 UPF0276 protein CH621_08305 ENOG4109045 doxx family CH621_08310 ENOG4107IX6 phosphate transport regulator CH621_08315 ENOG4105CJ3 phosphate transporter CH621_08330 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) CH621_08340 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CH621_08355 ENOG4107QI1 Mate efflux family protein CH621_08360 ENOG4108R6K riboflavin synthase, subunit alpha CH621_08365 ENOG4105CD8 aminopeptidase N CH621_08380 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CH621_08385 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CH621_08390 ENOG4105CGF Aromatic amino acid aminotransferase CH621_08395 ENOG4108JJB ABC transporter CH621_08405 ENOG4107XQ1 cobalamin (vitamin B12) biosynthesis CbiM protein CH621_08410 ENOG4108A51 CH621_08415 ENOG4105UZ0 ABC-type Co2 transport system, periplasmic component CH621_08420 ENOG4105W1Y Transcriptional regulator CH621_08430 ENOG4108VTV Inherit from NOG: Membrane CH621_08435 ENOG4105M4H endoribonuclease L-psp CH621_08440 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III CH621_08500 ENOG4105CM6 amino acid regulated cytosolic protein CH621_08505 ENOG4108EVY peptide transport periplasmic protein CH621_08515 ENOG4108EU3 peptide transport system, permease CH621_08520 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein CH621_08530 ENOG4105HMI Membrane CH621_08550 ENOG4105DAA L-lactate CH621_08570 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CH621_08575 ENOG4105T95 Thiol disulfide interChange protein CH621_08590 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CH621_08600 ENOG4105ECP epimerase CH621_08605 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CH621_08610 ENOG4105E96 Colicin v production protein CH621_08615 ENOG4105PQ6 UPF0208 membrane protein CH621_08625 ENOG4108DNC Involved in acetate metabolism (By similarity) CH621_08630 ENOG4108DG9 Smr protein MutS2 CH621_08635 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) CH621_08640 ENOG4107R11 Transcriptional regulator CH621_08645 ENOG4105FE9 pseudouridine synthase CH621_08650 ENOG4107RTD sua5 ycio yrdc ywlc family protein CH621_08655 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CH621_08665 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) CH621_08670 ENOG4105ETT transcriptional Regulator, LysR family CH621_08675 ENOG4105CM2 brancheD-chain amino acid aminotransferase CH621_08690 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CH621_08695 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CH621_08705 ENOG4105C4R Atp-dependent dna helicase CH621_08710 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CH621_08715 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CH621_08720 ENOG4105C3U ABC transporter CH621_08725 ENOG4108JQ7 (ABC) transporter CH621_08740 ENOG4105E5Z arginine transporter ATP-binding subunit CH621_08745 ENOG4106PMH Extracellular solute-binding protein family 3 CH621_08750 ENOG4105GBT ABC transporter CH621_08755 ENOG4105DMR ABC, transporter CH621_08765 ENOG41065S8 Opacity family porin protein CH621_08770 ENOG4105GPY SprT protein CH621_08780 ENOG4105DDQ anthranilate synthase CH621_08795 ENOG41090HJ UPF0265 protein CH621_08800 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CH621_08815 ENOG4105W44 ompa motb domain protein CH621_08820 ENOG4105CQB FAD linked oxidase domain protein CH621_08825 ENOG4105KA0 thioesterase Superfamily protein CH621_08830 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CH621_08835 ENOG4107QR8 Thioredoxin CH621_08840 ENOG4105C3M thioredoxin reductase CH621_08845 ENOG4108JJ9 ABC, transporter CH621_08850 ENOG4108JJ8 (ABC) transporter CH621_08860 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) CH621_08865 ENOG4107R6U sodium dicarboxylate symporter CH621_08870 ENOG4105CCF Lysine exporter protein (Lyse ygga) CH621_08875 ENOG4108UGV hypoxanthine phosphoribosyltransferase CH621_08880 ENOG4105CMS peptidase U62, modulator of DNA gyrase CH621_08885 ENOG4105N42 UPF0307 protein CH621_08890 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) CH621_08895 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA CH621_08900 ENOG4108IUZ ABC transporter CH621_08905 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN CH621_08910 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CH621_08915 ENOG4105CQC Prephenate dehydratase CH621_08925 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CH621_08930 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CH621_08935 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) CH621_08955 ENOG4105CNI cell division protein FtsW CH621_08970 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) CH621_08980 ENOG4105CJN penicillin-binding protein CH621_09015 ENOG4108J59 Extracellular solute-binding protein, family 5 CH621_09020 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CH621_09025 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CH621_09030 ENOG4105C3U ABC transporter CH621_09035 ENOG4108JQ7 (ABC) transporter CH621_09040 ENOG4108MJ5 VirK protein CH621_09050 ENOG4105C0P Mg chelatase subunit ChlI CH621_09060 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CH621_09070 ENOG4105CMG Carbohydrate kinase CH621_09080 ENOG4105C87 Aminotransferase class I and II CH621_09085 ENOG4105DFD Na H antiporter CH621_09090 ENOG4105T16 Transcriptional regulator (AraC family) CH621_09095 ENOG4105XA0 heptosyltransferase ii CH621_09100 ENOG4107RGD Major Facilitator superfamily CH621_09105 ENOG4105C6T cysteine synthase CH621_09135 ENOG4108M1T Cytochrome c-type biogenesis protein CH621_09140 ENOG4108M1T Cytochrome c-type biogenesis protein CH621_09145 ENOG4107QX9 Thiol disulfide interChange protein CH621_09150 ENOG4105DA4 cytochrome c-type biogenesis protein CH621_09160 ENOG4105X3C heme exporter protein CH621_09165 ENOG41060IM Heme exporter protein CH621_09170 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) CH621_09180 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CH621_09185 ENOG4105DHJ ABC, transporter CH621_09190 ENOG4105CY3 ABC transporter, permease CH621_09195 ENOG4107PE3 Mammalian cell entry related domain protein CH621_09200 ENOG4105E3I toluene tolerance CH621_09210 ENOG4105VFK BolA family CH621_09220 ENOG4105EAB amino acid AbC transporter CH621_09225 ENOG4105E5Q amino acid AbC transporter CH621_09230 ENOG4105CDA abc transporter atp-binding protein CH621_09250 ENOG4105C4M (Ubiquinol oxidase) subunit I CH621_09255 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CH621_09265 ENOG4105M08 Membrane CH621_09270 ENOG4105CQ7 ATP-dependent helicase CH621_09280 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit CH621_09285 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CH621_09290 ENOG4105DVI reductase, NrfD CH621_09300 ENOG4108I6E Sulfatase CH621_09305 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CH621_09330 ENOG4107QMH DNA methylase CH621_09335 ENOG4107J0C type IIi CH621_09345 ENOG4105E7U AraC family transcriptional regulator CH621_09350 ENOG4105BZ1 (ABC) transporter CH621_09355 ENOG410681U heavy metal transport detoxification protein CH621_09365 ENOG4108KS2 transglutaminase domain protein CH621_09370 ENOG4107QY8 reductase CH621_09375 ENOG4105QAX Iron-sulfur CH621_09380 ENOG4107KGK dmso reductase anchor subunit CH621_09385 ENOG4108NEM leader-binding protein dmsD CH621_09390 ENOG4105N1P Ferredoxin-type protein CH621_09410 ENOG4105E4P ATPase (AAA CH621_09415 ENOG4105E7A Glutamine amidotransferase CH621_09420 ENOG4108VIA integral membrane protein CH621_09430 ENOG4108VPT UPF0234 protein CH621_09435 ENOG4105EAC phosphoserine phosphatase CH621_09440 ENOG41069M3 Transcriptional regulator CH621_09445 ENOG4105DG4 malate L-lactate dehydrogenase CH621_09450 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter CH621_09455 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH621_09460 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CH621_09465 ENOG4105CMG Carbohydrate kinase CH621_09470 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase CH621_09475 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase CH621_09485 ENOG4105CV1 Transketolase (EC 2.2.1.1) CH621_09495 ENOG4107T0D ABC, transporter CH621_09500 ENOG4106SMU thiamine transporter membrane protein CH621_09505 ENOG4105DP9 ABC transporter CH621_09510 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein CH621_09525 ENOG4108I6E Sulfatase CH621_09530 ENOG4105EIN peptidylprolyl cis-trans isomerase CH621_09535 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CH621_09555 ENOG4105VG0 50S ribosomal protein l34 CH621_09570 ENOG4108MVK Receptor