locus-tag	class	description
CV728_00020	COG0708	Exodeoxyribonuclease III
CV728_00035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CV728_00070	COG0195	Participates in both transcription termination and antitermination
CV728_00095	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CV728_00100	COG0348	domain, Protein
CV728_00110	COG0786	glutamate:sodium symporter activity
CV728_00120	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CV728_00165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CV728_00175	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CV728_00180	COG0306	phosphate transporter
CV728_00185	COG1253	flavin adenine dinucleotide binding
CV728_00195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CV728_00210	COG1739	Uncharacterized protein family UPF0029
CV728_00220	COG2226	methyltransferase
CV728_00235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CV728_00255	COG0163	prenyltransferase activity
CV728_00260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CV728_00300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CV728_00300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CV728_00310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CV728_00320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CV728_00325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CV728_00350	COG0587	DNA-directed DNA polymerase activity
CV728_00355	COG1187	pseudouridine synthase activity
CV728_00360	COG3118	belongs to the thioredoxin family
CV728_00400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CV728_00410	COG0706	membrane insertase activity
CV728_00430	COG0848	biopolymer transport protein
CV728_00435	COG0811	peptide transport
CV728_00445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CV728_00450	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CV728_00455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CV728_00500	COG0788	formyltetrahydrofolate deformylase activity
CV728_00520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CV728_00525	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CV728_00530	COG0517	IMP dehydrogenase activity
CV728_00530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CV728_00555	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CV728_00565	COG4962	Type ii secretion system protein e
CV728_00570	COG1157	protein secretion by the type III secretion system
CV728_00575	COG1987	bacterial-type flagellum assembly
CV728_00580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CV728_00595	COG0793	Belongs to the peptidase S41A family
CV728_00605	COG0204	Acyl-transferase
CV728_00620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CV728_00625	COG0126	phosphoglycerate kinase activity
CV728_00630	COG0598	Magnesium transport protein CorA
CV728_00635	COG0861	Integral membrane protein TerC family
CV728_00645	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CV728_00650	COG0848	biopolymer transport protein
CV728_00655	COG0811	peptide transport
CV728_00665	COG0864	Transcriptional regulator
CV728_00670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CV728_00680	COG0482	sulfurtransferase activity
CV728_00690	COG0484	heat shock protein binding
CV728_00695	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CV728_00700	COG1687	branched-chain amino acid
CV728_00705	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CV728_00710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CV728_00725	COG0114	fumarate hydratase activity
CV728_00735	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CV728_00750	COG0051	transcription antitermination factor activity, RNA binding
CV728_00755	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CV728_00760	COG0088	Forms part of the polypeptide exit tunnel
CV728_00780	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CV728_00785	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CV728_00805	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CV728_00835	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CV728_00850	COG0201	protein transport
CV728_00855	COG0024	Methionine aminopeptidase
CV728_00880	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CV728_00885	COG0202	RNA polymerase activity
CV728_00915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CV728_00920	COG2353	YceI-like domain
CV728_00930	COG0859	PFAM glycosyl transferase family 9
CV728_00935	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CV728_00940	COG0512	Glutamine amidotransferase of anthranilate synthase
CV728_00950	COG0135	phosphoribosylanthranilate isomerase activity
CV728_00950	COG0134	indole-3-glycerol-phosphate synthase activity
CV728_00955	COG0133	tryptophan synthase activity
CV728_00960	COG0159	tryptophan synthase activity
CV728_00980	COG1007	ATP synthesis coupled electron transport
CV728_00990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CV728_01000	COG0839	Belongs to the complex I subunit 6 family
CV728_01005	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CV728_01035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CV728_01045	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CV728_01050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CV728_01060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CV728_01065	COG0233	cytoplasmic translational termination
CV728_01070	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CV728_01080	COG0180	Tryptophanyl-tRNA synthetase
CV728_01090	COG4174	ABC transporter (Permease)
CV728_01105	COG0557	exoribonuclease II activity
CV728_01110	COG1466	dna polymerase III delta subunit
CV728_01125	COG0629	single-stranded DNA binding
CV728_01150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CV728_01155	COG0424	maF-like protein
CV728_01165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CV728_01170	COG0505	Belongs to the CarA family
CV728_01185	COG0697	spore germination
CV728_01195	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CV728_01210	COG0527	aspartate kinase activity
CV728_01220	COG2863	cytochrome
CV728_01225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CV728_01250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CV728_01255	COG1131	(ABC) transporter
CV728_01280	COG0151	Belongs to the GarS family
CV728_01320	COG1045	serine acetyltransferase
CV728_01350	COG1132	(ABC) transporter
CV728_01375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CV728_01395	COG0250	Participates in transcription elongation, termination and antitermination
CV728_01435	COG0049	tRNA binding
CV728_01445	COG0667	Aldo Keto reductase
CV728_01460	COG0859	PFAM glycosyl transferase family 9
CV728_01465	COG0124	histidyl-tRNA synthetase
CV728_01470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CV728_01500	COG0569	domain protein
CV728_01500	COG0475	glutathione-regulated potassium exporter activity
CV728_01505	COG0037	tRNA processing
CV728_01510	COG2814	Major facilitator Superfamily
CV728_01520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CV728_01530	COG0813	purine-nucleoside phosphorylase activity
CV728_01545	COG2252	PERMEase
CV728_01550	COG0738	Major facilitator superfamily
CV728_01565	COG1126	abc transporter atp-binding protein
CV728_01570	COG0765	amino acid transport
CV728_01580	COG1966	Carbon starvation protein
CV728_01605	COG0492	ferredoxin-NADP+ reductase activity
CV728_01620	COG0716	FMN binding
CV728_01630	COG2184	nucleotidyltransferase activity
CV728_01635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CV728_01650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CV728_01655	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CV728_01660	COG0525	valine-tRNA ligase activity
CV728_01665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CV728_01680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CV728_01685	COG0336	Belongs to the RNA methyltransferase TrmD family
CV728_01740	COG1192	Involved in chromosome partitioning
CV728_01745	COG1475	DNA binding
CV728_01785	COG0811	peptide transport
CV728_01790	COG0848	biopolymer transport protein
CV728_01800	COG0823	Involved in the tonB-independent uptake of proteins
CV728_01805	COG2885	chlorophyll binding
CV728_01815	COG1047	Peptidyl-prolyl cis-trans
CV728_01845	COG0405	Gamma-glutamyltransferase
CV728_01885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CV728_01890	COG1013	pyruvate-flavodoxin oxidoreductase activity
CV728_01895	COG0674	pyruvate-flavodoxin oxidoreductase activity
CV728_01905	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CV728_01935	COG1064	alcohol dehydrogenase
CV728_01945	COG0363	glucosamine-6-phosphate deaminase activity
CV728_01950	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CV728_01955	COG0129	dihydroxy-acid dehydratase activity
CV728_01960	COG0800	Aldolase
CV728_01965	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CV728_01970	COG4221	oxidoreductase activity
CV728_02010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CV728_02020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CV728_02040	COG0439	Biotin carboxylase
CV728_02045	COG0511	ligase activity, forming carbon-carbon bonds
CV728_02060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CV728_02070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CV728_02080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CV728_02080	COG1333	cytochrome c biogenesis protein
CV728_02090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CV728_02095	COG2890	protein-(glutamine-N5) methyltransferase activity
CV728_02100	COG0501	Belongs to the peptidase M48B family
CV728_02125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CV728_02135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CV728_02140	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CV728_02150	COG2198	Histidine kinase
CV728_02150	COG0643	Histidine kinase
CV728_02155	COG0784	Response regulator, receiver
CV728_02155	COG0835	chemotaxis
CV728_02165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CV728_02170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CV728_02175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CV728_02185	COG1185	polyribonucleotide nucleotidyltransferase activity
CV728_02185	COG0539	negative regulation of cytoplasmic translation
CV728_02200	COG0072	phenylalanine-tRNA ligase activity
CV728_02200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CV728_02205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CV728_02210	COG0537	adenosine 5'-monophosphoramidase activity
CV728_02215	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CV728_02270	COG0668	transmembrane transport
CV728_02275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CV728_02280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CV728_02280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CV728_02290	COG0500	methyltransferase
CV728_02305	COG1166	arginine decarboxylase activity
CV728_02370	COG0668	transmembrane transport
CV728_02390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CV728_02395	COG0849	cell division
CV728_02405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CV728_02410	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CV728_02415	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CV728_02475	COG0752	glycyl-tRNA synthetase alpha subunit
CV728_02480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CV728_02490	COG1519	Transferase
CV728_02495	COG0564	pseudouridine synthase activity
CV728_02500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CV728_02505	COG0778	Nitroreductase
CV728_02515	COG1058	Belongs to the CinA family
CV728_02515	COG1546	Belongs to the CinA family
CV728_02525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CV728_02545	COG1757	Na H antiporter
CV728_02575	COG0251	oxidation-reduction process
CV728_02580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CV728_02585	COG1115	amino acid carrier protein
CV728_02595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CV728_02600	COG0765	amino acid transport
CV728_02630	COG0602	queuosine metabolic process
CV728_02635	COG0720	synthase
CV728_02650	COG0142	geranyltranstransferase activity
CV728_02660	COG0501	Belongs to the peptidase M48B family
CV728_02665	COG0585	pseudouridine synthase activity
CV728_02675	COG1942	4-Oxalocrotonate Tautomerase
CV728_02690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CV728_02695	COG0670	Belongs to the BI1 family
CV728_02700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CV728_02745	COG1749	Flagellar hook protein flgE
CV728_02745	COG1749	Flagellar hook protein flgE
CV728_02750	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CV728_02780	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CV728_02785	COG0298	carbon dioxide binding
CV728_02790	COG0409	Hydrogenase expression formation protein
CV728_02825	COG3309	Virulence-associated protein D
CV728_02830	COG1607	acyl-coa hydrolase
CV728_02835	COG0300	oxidoreductase activity
CV728_02840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CV728_02845	COG1120	ATPase activity
CV728_02855	COG0215	cysteine-tRNA ligase activity
CV728_02860	COG0728	peptidoglycan biosynthetic process
CV728_02870	COG0632	four-way junction helicase activity
CV728_02920	COG0824	Thioesterase
CV728_02925	COG0733	neurotransmitter:sodium symporter activity
CV728_02930	COG0733	neurotransmitter:sodium symporter activity
CV728_02940	COG0592	DNA-directed DNA polymerase activity
CV728_02945	COG0187	DNA topoisomerase II activity
CV728_02960	COG0741	lytic transglycosylase activity
CV728_02960	COG1196	nuclear chromosome segregation
CV728_02960	COG0739	heme binding
CV728_02975	COG0277	FAD linked oxidase domain protein
CV728_02980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CV728_03000	COG3451	type IV secretory pathway VirB4
CV728_03090	COG2948	multi-organism process
CV728_03140	COG0174	glutamine synthetase
CV728_03150	COG0359	binds to the 23S rRNA
CV728_03155	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CV728_03165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CV728_03215	COG1842	Phage shock protein A
CV728_03235	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CV728_03240	COG0254	rRNA binding
CV728_03245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CV728_03250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CV728_03280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CV728_03290	COG1028	Short-chain dehydrogenase reductase Sdr
CV728_03320	COG0628	permease
CV728_03355	COG0698	ribose 5-phosphate isomerase
CV728_03360	COG1994	Peptidase M50
CV728_03365	COG0681	Belongs to the peptidase S26 family
CV728_03405	COG1776	CheC inhibitor of MCP methylation
CV728_03405	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CV728_03410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CV728_03415	COG1918	ferrous iron import across plasma membrane
CV728_03435	COG0674	pyruvate-flavodoxin oxidoreductase activity
CV728_03435	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CV728_03440	COG1013	pyruvate-flavodoxin oxidoreductase activity
CV728_03475	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CV728_03480	COG0156	8-amino-7-oxononanoate synthase activity
CV728_03485	COG0840	transmembrane signaling receptor activity
CV728_03500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CV728_03515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CV728_03540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CV728_03550	COG1131	(ABC) transporter
CV728_03560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CV728_03565	COG0745	RESPONSE REGULATOR receiver
CV728_03575	COG0563	adenylate kinase activity
CV728_03590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CV728_03595	COG1193	negative regulation of DNA recombination
CV728_03610	COG0436	Aminotransferase
CV728_03620	COG2171	N-acyltransferase activity
CV728_03635	COG2249	NAD(P)H dehydrogenase (quinone) activity
CV728_03640	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CV728_03645	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CV728_03650	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CV728_03655	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CV728_03660	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CV728_03690	COG2084	Dehydrogenase
CV728_03695	COG0778	Nitroreductase
CV728_03705	COG0762	integral membrane protein
CV728_03730	COG1027	Aspartate ammonia-lyase
CV728_03745	COG0560	Phosphoserine phosphatase
CV728_03750	COG1528	Iron-storage protein
CV728_03755	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CV728_03760	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CV728_03765	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CV728_03775	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CV728_03790	COG0328	RNA-DNA hybrid ribonuclease activity
CV728_03810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CV728_03840	COG4974	Belongs to the 'phage' integrase family
CV728_03850	COG0730	response to heat
CV728_03860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CV728_03885	COG1338	Plays a role in the flagellum-specific transport system
CV728_03895	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CV728_03905	COG0183	Belongs to the thiolase family
CV728_03910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CV728_03915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CV728_03920	COG2031	fatty acid transporter
CV728_03930	COG0145	ligase activity
CV728_03935	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CV728_03940	COG4647	ligase activity
CV728_03950	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CV728_03955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CV728_03965	COG2204	response regulator
CV728_03980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CV728_04000	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
CV728_04015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CV728_04020	COG1137	ATPase activity
CV728_04035	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CV728_04040	COG1279	arginine transmembrane transporter activity
CV728_04060	COG0252	asparaginase activity
CV728_04065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CV728_04080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CV728_04085	COG0037	tRNA processing
CV728_04125	COG3451	type IV secretory pathway VirB4
CV728_04130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CV728_04165	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CV728_04195	COG3041	Addiction module toxin RelE StbE family
CV728_04265	COG1943	Transposase
CV728_04280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CV728_04285	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CV728_04290	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CV728_04295	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CV728_04310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CV728_04320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CV728_04330	COG0772	Belongs to the SEDS family
CV728_04340	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CV728_04350	COG0564	pseudouridine synthase activity
CV728_04360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CV728_04365	COG2884	Cell division ATP-binding protein ftsE
CV728_04400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CV728_04415	COG2056	Na+-H+ antiporter family
CV728_04420	COG0534	Mate efflux family protein
CV728_04440	COG0552	protein localization to endoplasmic reticulum
CV728_04460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CV728_04465	COG0746	molybdenum cofactor guanylyltransferase activity
CV728_04470	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CV728_04480	COG0860	N-Acetylmuramoyl-L-alanine amidase
CV728_04490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CV728_04500	COG1758	RNA polymerase activity
CV728_04505	COG0528	UMP kinase activity
CV728_04545	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CV728_04550	COG0653	protein targeting
CV728_04580	COG2217	Heavy metal translocating P-type atpase
CV728_04585	COG0606	chelatase, subunit chli
CV728_04620	COG0521	Mo-molybdopterin cofactor biosynthetic process
CV728_04625	COG0314	molybdopterin synthase activity
CV728_04645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CV728_04645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CV728_04670	COG1580	Controls the rotational direction of flagella during chemotaxis
CV728_04690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CV728_04695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CV728_04700	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CV728_04705	COG1360	Flagellar Motor Protein
CV728_04715	COG1732	Glycine betaine
CV728_04720	COG1125	glycine betaine transport
CV728_04720	COG0517	IMP dehydrogenase activity
CV728_04735	COG0322	excinuclease ABC activity
CV728_04740	COG0460	homoserine dehydrogenase
CV728_04750	COG3118	belongs to the thioredoxin family
CV728_04755	COG0492	ferredoxin-NADP+ reductase activity
CV728_04765	COG0724	RNA recognition motif
CV728_04775	COG0517	IMP dehydrogenase activity
CV728_04775	COG0516	GMP reductase activity
CV728_04780	COG0154	amidase activity
CV728_04785	COG0237	dephospho-CoA kinase activity
CV728_04790	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CV728_04805	COG0776	regulation of translation
CV728_04830	COG1086	Polysaccharide biosynthesis protein
CV728_04835	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CV728_04845	COG0352	thiamine-phosphate diphosphorylase activity
CV728_04850	COG0351	phosphomethylpyrimidine kinase
CV728_04855	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CV728_04880	COG0671	phosphoesterase, PA-phosphatase related
CV728_04890	COG0488	(ABC) transporter
CV728_04905	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CV728_04905	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CV728_04910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CV728_04915	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CV728_04925	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CV728_04940	COG0756	dUTP diphosphatase activity
CV728_04945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CV728_04960	COG0375	protein maturation
CV728_04965	COG1749	Flagellar hook protein flgE
CV728_04970	COG2134	cdp-diacylglycerol pyrophosphatase
CV728_04980	COG2824	Alkylphosphonate utilization operon protein PhnA
CV728_04995	COG0753	catalase activity
CV728_05170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CV728_05175	COG0167	dihydroorotate dehydrogenase activity
CV728_05185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CV728_05190	COG1028	Short-chain dehydrogenase reductase Sdr
CV728_05200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CV728_05205	COG0833	amino acid
CV728_05220	COG0745	RESPONSE REGULATOR receiver
CV728_05235	COG0484	heat shock protein binding
CV728_05240	COG0789	Transcriptional regulator
CV728_05245	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CV728_05245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CV728_05250	COG0735	belongs to the Fur family
CV728_05265	COG1776	CheC inhibitor of MCP methylation
CV728_05265	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CV728_05270	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CV728_05275	COG1191	sigma factor activity
CV728_05285	COG0455	bacterial-type flagellum organization
CV728_05290	COG1419	protein localization to endoplasmic reticulum
CV728_05295	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CV728_05300	COG0006	proline dipeptidase activity
CV728_05320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CV728_05325	COG2404	hydrolase activity, acting on ester bonds
CV728_05330	COG0745	RESPONSE REGULATOR receiver
CV728_05335	COG1408	metallophosphoesterase
CV728_05365	COG0083	homoserine kinase activity
CV728_05420	COG0805	protein transport
CV728_05430	COG0357	Ribosomal RNA small subunit methyltransferase G
CV728_05465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CV728_05475	COG1183	phosphatidylcholine synthase activity
CV728_05485	COG2608	mercury ion transmembrane transporter activity
CV728_05505	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CV728_05530	COG1132	(ABC) transporter
CV728_05540	COG0540	Belongs to the ATCase OTCase family
CV728_05550	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CV728_05555	COG0196	riboflavin kinase activity
CV728_05560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CV728_05575	COG0477	Major facilitator Superfamily
CV728_05580	COG4786	Flagellar basal body rod
CV728_05620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CV728_05630	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CV728_05635	COG1766	The M ring may be actively involved in energy transduction
CV728_05645	COG0504	CTP synthase activity
CV728_05650	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CV728_05650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CV728_05655	COG0564	pseudouridine synthase activity
CV728_05700	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CV728_05710	COG0758	DNA mediated transformation
CV728_05710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CV728_05715	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CV728_05720	COG2894	cell division
CV728_05740	COG1663	tetraacyldisaccharide 4'-kinase activity
CV728_05745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CV728_05755	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CV728_05780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CV728_05790	COG0748	coenzyme F420 binding
CV728_05810	COG3309	Virulence-associated protein D
CV728_05835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CV728_05870	COG4608	Belongs to the ABC transporter superfamily
CV728_05875	COG0444	Belongs to the ABC transporter superfamily
CV728_05880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CV728_05885	COG0601	transmembrane transport
CV728_05890	COG0747	negative chemotaxis
CV728_05915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CV728_05930	COG0019	diaminopimelate decarboxylase activity
CV728_05950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CV728_05955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CV728_05985	COG0859	PFAM glycosyl transferase family 9
CV728_05990	COG0248	Ppx GppA phosphatase
CV728_06000	COG0134	indole-3-glycerol-phosphate synthase activity
CV728_06010	COG0727	PFAM Uncharacterised protein family (UPF0153)
CV728_06035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CV728_06045	COG0402	S-adenosylhomocysteine deaminase activity
CV728_06050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CV728_06055	COG0785	Cytochrome C biogenesis protein
CV728_06060	COG0542	response to heat
CV728_06095	COG0750	zinc metalloprotease
CV728_06135	COG4172	Belongs to the ABC transporter superfamily
CV728_06160	COG3951	Flagellar rod assembly protein muramidase FlgJ
CV728_06170	COG0783	Belongs to the Dps family
CV728_06195	COG0442	prolyl-tRNA aminoacylation
CV728_06210	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CV728_06220	COG0754	glutathionylspermidine amidase activity
CV728_06235	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CV728_06250	COG0659	secondary active sulfate transmembrane transporter activity
CV728_06265	COG0730	response to heat
CV728_06270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CV728_06270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CV728_06275	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CV728_06305	COG1881	PFAM PEBP family protein
CV728_06320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CV728_06325	COG0575	Belongs to the CDS family
CV728_06330	COG0471	metal ion transport
CV728_06345	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CV728_06360	COG4974	Belongs to the 'phage' integrase family
CV728_06365	COG3177	Filamentation induced by cAMP protein fic
CV728_06415	COG1192	Involved in chromosome partitioning
CV728_06425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CV728_06450	COG4962	Type ii secretion system protein e
CV728_06490	COG3451	type IV secretory pathway VirB4
CV728_06540	COG0489	protein tyrosine kinase activity
CV728_06570	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CV728_06595	COG0582	viral genome integration into host DNA
CV728_06615	COG1943	Transposase
CV728_06635	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CV728_06640	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CV728_06655	COG1053	succinate dehydrogenase
CV728_06660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CV728_06665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CV728_06705	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CV728_06710	COG1136	(ABC) transporter
CV728_06715	COG2089	acid synthase
CV728_06725	COG0191	fructose-bisphosphate aldolase activity
CV728_06730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CV728_06750	COG0303	'Molybdopterin
CV728_06785	COG2205	protein histidine kinase activity
CV728_06790	COG0113	porphobilinogen synthase activity
CV728_06795	COG0217	transcriptional regulatory protein
CV728_06805	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CV728_06835	COG0148	phosphopyruvate hydratase activity
CV728_06885	COG3278	Belongs to the heme-copper respiratory oxidase family
CV728_06895	COG1194	a g-specific adenine glycosylase
CV728_06905	COG1620	l-lactate permease
CV728_06910	COG1620	l-lactate permease
CV728_06915	COG0247	lactate metabolic process
CV728_06920	COG1139	Iron-sulfur cluster binding protein
CV728_06930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CV728_06940	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CV728_06945	COG0814	amino acid
CV728_06950	COG1760	l-serine dehydratase
CV728_06975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CV728_06985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CV728_07000	COG0574	Belongs to the PEP-utilizing enzyme family
CV728_07000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CV728_07015	COG0731	radical SAM domain protein
CV728_07020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CV728_07020	COG0551	DNA topoisomerase type I activity
CV728_07025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CV728_07045	COG1420	regulation of RNA biosynthetic process
CV728_07065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CV728_07070	COG0626	cystathionine gamma-synthase activity
CV728_07080	COG0737	Belongs to the 5'-nucleotidase family
CV728_07090	COG1216	Glycosyl transferase, family 2
CV728_07100	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CV728_07105	COG0840	transmembrane signaling receptor activity
CV728_07110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CV728_07120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CV728_07155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CV728_07160	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CV728_07165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CV728_07195	COG0840	transmembrane signaling receptor activity
CV728_07235	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CV728_07250	COG0804	urea catabolic process
CV728_07265	COG0830	nickel cation binding
CV728_07320	COG0745	RESPONSE REGULATOR receiver
CV728_07330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CV728_07330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CV728_07335	COG0305	Participates in initiation and elongation during chromosome replication
CV728_07345	COG0109	protoheme IX farnesyltransferase activity
CV728_07365	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CV728_07370	COG0157	Belongs to the NadC ModD family
CV728_07420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CV728_07425	COG0506	proline dehydrogenase activity
CV728_07425	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CV728_07425	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CV728_07470	COG1598	PFAM Uncharacterised protein family UPF0150
CV728_07490	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CV728_07495	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CV728_07510	COG1077	Cell shape determining protein MreB Mrl
CV728_07515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CV728_07525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CV728_07535	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CV728_07540	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CV728_07545	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CV728_07550	COG0287	Prephenate dehydrogenase
CV728_07565	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CV728_07570	COG3421	Type III restriction
CV728_07580	COG1295	ribonuclease BN
CV728_07625	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CV728_07630	COG0799	negative regulation of ribosome biogenesis
CV728_07635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CV728_07660	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CV728_07675	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CV728_07720	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CV728_07725	COG0542	response to heat
CV728_07730	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CV728_07735	COG0589	response to stress
CV728_07755	COG0538	isocitrate dehydrogenase activity
CV728_07760	COG0372	Belongs to the citrate synthase family
CV728_07785	COG2194	sulfuric ester hydrolase activity
CV728_07790	COG0671	phosphoesterase, PA-phosphatase related
CV728_07800	COG0745	RESPONSE REGULATOR receiver
CV728_07835	COG0482	sulfurtransferase activity
CV728_07840	COG0358	DNA primase activity
CV728_07895	COG0284	orotidine-5'-phosphate decarboxylase activity
CV728_07900	COG0288	reversible hydration of carbon dioxide
CV728_07905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CV728_07925	COG4735	regulation of single-species biofilm formation
CV728_07940	COG4735	regulation of single-species biofilm formation
CV728_07950	COG4786	Flagellar basal body rod
CV728_07970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CV728_07975	COG0671	phosphoesterase, PA-phosphatase related
CV728_07985	COG2011	ABC-type metal ion transport system permease component
CV728_08000	COG0307	riboflavin synthase, alpha
CV728_08005	COG0084	hydrolase, TatD family'
CV728_08010	COG0741	lytic transglycosylase activity
CV728_08010	COG1388	LysM domain
CV728_08015	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CV728_08020	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CV728_08045	COG0768	penicillin binding
CV728_08060	COG0450	alkyl hydroperoxide reductase
CV728_08075	COG0772	Belongs to the SEDS family
CV728_08080	COG1815	bacterial-type flagellum-dependent cell motility
CV728_08085	COG1558	bacterial-type flagellum-dependent cell motility
CV728_08100	COG0768	penicillin binding
CV728_08105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CV728_08115	COG1074	ATP-dependent DNA helicase activity
CV728_08125	COG1862	Preprotein translocase
CV728_08135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CV728_08155	COG0285	dihydrofolate synthase activity
CV728_08165	COG0739	heme binding
CV728_08175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CV728_08180	COG0723	plastoquinol--plastocyanin reductase activity
CV728_08210	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CV728_08215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CV728_08225	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CV728_08355	COG0358	DNA primase activity
CV728_08410	COG0497	DNA recombination
CV728_08430	COG1064	alcohol dehydrogenase
CV728_08435	COG0686	Belongs to the AlaDH PNT family
CV728_08440	COG0010	Belongs to the arginase family
CV728_08455	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CV728_08475	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CV728_08480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity