locus-tag	class	description
Igni_0001	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Igni_0002	ENOG4105CQB	FAD linked oxidase domain protein
Igni_0007	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Igni_0009	ENOG4105CY0	Metallo-Beta-Lactamase
Igni_0011	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
Igni_0013	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Igni_0018	ENOG4105D49	3-dehydroquinate synthase
Igni_0020	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
Igni_0022	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
Igni_0029	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Igni_0030	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
Igni_0036	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
Igni_0038	ENOG4108JJB	ABC transporter
Igni_0040	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
Igni_0041	ENOG4108MGF	sugar kinase
Igni_0042	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
Igni_0043	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
Igni_0044	ENOG4105CXT	aspartate transcarbamylase
Igni_0047	ENOG41060IM	Heme exporter protein
Igni_0051	ENOG4105DR4	Methyltransferase
Igni_0056	ENOG4105D64	Mechanosensitive ion channel
Igni_0057	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Igni_0065	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Igni_0067	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Igni_0077	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Igni_0079	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
Igni_0085	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Igni_0086	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Igni_0087	ENOG4106Z6D	Molecular chaperone capable of stabilizing a range of proteins (By similarity)
Igni_0089	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Igni_0092	ENOG4108T9Q	UPF0278 protein
Igni_0096	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Igni_0104	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
Igni_0107	ENOG4105E2Z	phosphate ABC transporter (Permease
Igni_0108	ENOG4105C8U	phosphate abc transporter
Igni_0109	ENOG4108Z4T	Peptidase M50
Igni_0110	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Igni_0111	ENOG4105DGU	Histone deacetylase
Igni_0118	ENOG4105DIK	(ABC) transporter
Igni_0122	ENOG4105F7P	transcriptional regulator AsnC family
Igni_0127	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
Igni_0128	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
Igni_0129	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
Igni_0132	ENOG4105C0A	alcohol dehydrogenase
Igni_0146	ENOG4105CJ1	ABC, transporter
Igni_0150	ENOG4105C8T	Leucyl-tRNA synthetase
Igni_0155	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
Igni_0156	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
Igni_0158	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
Igni_0160	ENOG4107Y49	methyltransferase
Igni_0161	ENOG4105CIG	ABC transporter
Igni_0162	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Igni_0163	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Igni_0165	ENOG4105C12	Phosphoribosylglycinamide synthetase
Igni_0167	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
Igni_0168	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Igni_0171	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Igni_0177	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Igni_0179	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Igni_0180	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Igni_0181	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Igni_0182	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Igni_0184	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Igni_0185	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Igni_0186	ENOG4108UJD	30S ribosomal protein S9
Igni_0188	ENOG4105CE9	30S ribosomal protein S2
Igni_0191	ENOG4107QRT	dEAD DEAH box helicase
Igni_0196	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Igni_0198	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Igni_0199	ENOG4105CFH	Aspartokinase
Igni_0201	ENOG4107RB3	L-asparaginase
Igni_0205	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Igni_0210	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Igni_0215	ENOG4105E2X	shikimate dehydrogenase
Igni_0220	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Igni_0227	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
Igni_0229	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
Igni_0230	ENOG4105XPM	ribosomal protein
Igni_0231	ENOG4105CAG	UPF0210 protein
Igni_0233	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Igni_0243	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Igni_0244	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Igni_0246	ENOG4105CHV	Transcription elongation factor NusA
Igni_0249	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Igni_0252	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Igni_0255	ENOG4107YZX	Universal stress protein
Igni_0256	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Igni_0257	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Igni_0260	ENOG4108ZAF	Molybdopterin
Igni_0261	ENOG4107SDT	Homocitrate synthase
Igni_0266	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Igni_0273	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Igni_0274	ENOG4105BZA	Phosphoglycerate kinase
Igni_0278	ENOG4107VRP	DNA repair exonuclease
Igni_0283	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Igni_0289	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
Igni_0293	ENOG4105EHU	Circadian clock protein KaiC
Igni_0294	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Igni_0301	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Igni_0303	ENOG4105VUC	UPF0237 protein
Igni_0304	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Igni_0306	ENOG4105EHU	Circadian clock protein KaiC
Igni_0307	ENOG4105CQC	Prephenate dehydratase
Igni_0311	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Igni_0313	ENOG4105C22	threonyL-tRNA synthetase
Igni_0315	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Igni_0323	ENOG4105EM7	Selenocysteine-specific translation elongation factor
Igni_0324	ENOG4105D52	delta-aminolevulinic acid dehydratase
Igni_0327	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
Igni_0331	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Igni_0334	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Igni_0337	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
Igni_0340	ENOG4105CSA	Coproporphyrinogen iii oxidase
Igni_0341	ENOG4108MYP	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
Igni_0343	ENOG4108MWI	inositol mono-phosphatase
Igni_0346	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Igni_0347	ENOG4105C31	Tryptophanyl-tRNA synthetase
Igni_0354	ENOG4105PW4	Sugar fermentation stimulation protein homolog
Igni_0362	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Igni_0363	ENOG4107NFR	Fructose-1,6-bisphosphatase
Igni_0368	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Igni_0374	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
Igni_0376	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Igni_0383	ENOG4108JQ1	Dehydrogenase
Igni_0384	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
Igni_0386	ENOG4105CD5	CoA-binding domain protein
Igni_0388	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
Igni_0392	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Igni_0395	ENOG4108Z0Z	intracellular protease Pfpi family
Igni_0400	ENOG4105C83	adenylosuccinate lyase
Igni_0401	ENOG4105VF7	tolerance protein
Igni_0402	ENOG41084A9	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Igni_0407	ENOG4105EYU	Glutamine amido-transferase
Igni_0408	ENOG4105CBC	glutamate synthase
Igni_0410	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Igni_0412	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
Igni_0413	ENOG4105CQS	hydrogenase expression formation protein HypD
Igni_0418	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
Igni_0420	ENOG41086B8	CoB-CoM heterodisulfide reductase
Igni_0428	ENOG4105E66	phosphoriboisomerase A
Igni_0431	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
Igni_0436	ENOG4105D9P	serine threonine protein kinase
Igni_0438	ENOG4108UVJ	appr-1-p processing domain protein
Igni_0440	ENOG4105CKK	Glycosyl transferase, family 2
Igni_0448	ENOG4105CV8	reductase
Igni_0456	ENOG4107YZX	Universal stress protein
Igni_0457	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
Igni_0459	ENOG4105D3R	alkyl hydroperoxide reductase
Igni_0460	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
Igni_0465	ENOG4105DK7	lysyl-tRNA synthetase
Igni_0466	ENOG4105DDQ	anthranilate synthase
Igni_0472	ENOG4105C8W	ABC transporter
Igni_0479	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Igni_0483	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Igni_0489	ENOG4105E5G	Alpha beta hydrolase fold
Igni_0490	ENOG4105C45	hydrogenase expression formation protein (HypE)
Igni_0495	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Igni_0506	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Igni_0512	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
Igni_0516	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
Igni_0519	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
Igni_0521	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Igni_0529	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
Igni_0531	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
Igni_0532	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
Igni_0536	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Igni_0539	ENOG4107R3E	Citrate transporter
Igni_0542	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Igni_0543	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Igni_0545	ENOG4105C8S	subunit m
Igni_0546	ENOG4105D65	subunit l
Igni_0548	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Igni_0550	ENOG4108JJB	ABC transporter
Igni_0559	ENOG4105CEV	competence damage-inducible protein
Igni_0560	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
Igni_0564	ENOG4107YZX	Universal stress protein
Igni_0568	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
Igni_0570	ENOG4105CAQ	asparagine synthetase
Igni_0571	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
Igni_0572	ENOG4105X9Y	Hydrogenase assembly chaperone hypC hupF
Igni_0573	ENOG4107RY6	amino acid
Igni_0580	ENOG4105C6T	cysteine synthase
Igni_0582	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Igni_0585	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Igni_0586	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Igni_0587	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Igni_0588	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Igni_0589	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Igni_0590	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Igni_0591	ENOG41082SA	50s ribosomal protein l29
Igni_0596	ENOG4105CD3	dihydroorotase
Igni_0598	ENOG4105C2X	Arabinose 5-phosphate isomerase
Igni_0600	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
Igni_0601	ENOG4107SVV	electron transport complex, RnfABCDGE type, B subunit
Igni_0604	ENOG4105CY0	Metallo-Beta-Lactamase
Igni_0606	ENOG4105NBF	ammecr1 domain protein
Igni_0607	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Igni_0608	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
Igni_0611	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Igni_0617	ENOG4105C3M	thioredoxin reductase
Igni_0620	ENOG4107YFT	Nadph-dependent fmn reductase
Igni_0621	ENOG4105CAS	nag kinase
Igni_0623	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
Igni_0628	ENOG4105CPQ	Dehydrogenase
Igni_0631	ENOG4105E0R	Deoxyhypusine synthase
Igni_0632	ENOG4105EUJ	GTP cyclohydrolase i
Igni_0633	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
Igni_0635	ENOG4105CDH	Citrulline--aspartate ligase
Igni_0637	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Igni_0645	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Igni_0648	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Igni_0649	ENOG4105DSU	hydrolase
Igni_0651	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Igni_0655	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Igni_0664	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Igni_0671	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
Igni_0674	ENOG4105C8H	hydrogenase maturation protein Hypf
Igni_0679	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
Igni_0683	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Igni_0684	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
Igni_0686	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Igni_0690	ENOG4105CQ2	DNA polymerase
Igni_0691	ENOG4105C2M	dna polymerase I
Igni_0693	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Igni_0696	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Igni_0704	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
Igni_0706	ENOG4108VVK	transcriptional Regulator, AsnC
Igni_0707	ENOG4107R56	PP-loop domain protein
Igni_0725	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
Igni_0728	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
Igni_0731	ENOG4105C0Z	ABC transporter
Igni_0732	ENOG4108IV0	ABC, transporter
Igni_0733	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
Igni_0738	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Igni_0747	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
Igni_0752	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
Igni_0754	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Igni_0756	ENOG4105CAT	Cytidine monophosphate kinase
Igni_0757	ENOG4105D1F	ATP-binding protein
Igni_0758	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
Igni_0765	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Igni_0766	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Igni_0773	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
Igni_0775	ENOG4105ESV	Glycosyl transferase, family 4
Igni_0788	ENOG41080HJ	6-phospho 3-hexuloisomerase
Igni_0796	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Igni_0799	ENOG4105D0M	Protease HtpX homolog
Igni_0801	ENOG4105QAX	Iron-sulfur
Igni_0802	ENOG4105DB1	molybdopterin oxidoreductase
Igni_0804	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
Igni_0805	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
Igni_0818	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
Igni_0825	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
Igni_0829	ENOG4107R3E	Citrate transporter
Igni_0843	ENOG4105C8V	SAICAR synthetase
Igni_0845	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
Igni_0853	ENOG4105C22	threonyL-tRNA synthetase
Igni_0857	ENOG4107QPI	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
Igni_0859	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Igni_0860	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Igni_0867	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
Igni_0868	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
Igni_0872	ENOG4105C9A	Phoh family
Igni_0873	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Igni_0875	ENOG4105E63	Pfam:DUF178
Igni_0877	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Igni_0879	ENOG4105CUT	histidyl-tRNA synthetase
Igni_0880	ENOG4105F0N	pyrophosphate phospho-hydrolase
Igni_0885	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Igni_0886	ENOG4107PBV	potassium channel
Igni_0888	ENOG4107ZCS	Phosphomethylpyrimidine kinase
Igni_0889	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Igni_0891	ENOG4108IUS	Transketolase
Igni_0892	ENOG4105CQC	Prephenate dehydratase
Igni_0900	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Igni_0904	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
Igni_0911	ENOG4105C3M	thioredoxin reductase
Igni_0916	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Igni_0921	ENOG41084I6	Protein CrcB homolog
Igni_0924	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Igni_0925	ENOG4105CRQ	synthase (Component I)
Igni_0926	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
Igni_0931	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Igni_0934	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Igni_0936	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
Igni_0938	ENOG4105C8T	Leucyl-tRNA synthetase
Igni_0942	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
Igni_0944	ENOG4105C8Y	Acetylornithine aminotransferase
Igni_0946	ENOG4105C5R	Aminotransferase
Igni_0947	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
Igni_0948	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Igni_0949	ENOG4105VG1	fes assembly suf system protein
Igni_0960	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
Igni_0961	ENOG4105C01	Dihydroxy-acid dehydratase
Igni_0962	ENOG4108I9W	Membrane
Igni_0963	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Igni_0964	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Igni_0966	ENOG41082UH	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Igni_0968	ENOG4107T1U	Catalyzes the synthesis of activated sulfate (By similarity)
Igni_0970	ENOG4107RIQ	Sulfate adenylate transferase
Igni_0975	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
Igni_0980	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
Igni_0982	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Igni_0983	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Igni_0990	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Igni_0991	ENOG4105C8N	cysteinyl-tRNA synthetase
Igni_0992	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
Igni_1002	ENOG4105CE1	Ferrous iron transport protein b
Igni_1007	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Igni_1017	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Igni_1021	ENOG4108J59	Extracellular solute-binding protein, family 5
Igni_1027	ENOG4108ZB6	transcriptional regulator AsnC family
Igni_1037	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
Igni_1040	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
Igni_1044	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Igni_1046	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Igni_1047	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Igni_1056	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Igni_1058	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Igni_1059	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Igni_1062	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Igni_1064	ENOG4108HMX	isocitrate dehydrogenase (NADP)
Igni_1077	ENOG4105DQU	oxidoreductase, subunit beta
Igni_1078	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Igni_1079	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
Igni_1084	ENOG4108SDH	ABC, transporter
Igni_1085	ENOG4105CJ1	ABC, transporter
Igni_1086	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
Igni_1087	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Igni_1091	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Igni_1092	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
Igni_1094	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Igni_1097	ENOG4105C7K	acetolactate synthase
Igni_1099	ENOG4105K59	histidine triad (HIT) protein
Igni_1100	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Igni_1102	ENOG4105C28	cystathionine
Igni_1103	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
Igni_1107	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Igni_1108	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
Igni_1110	ENOG4105CX6	glutaminyL-tRNA synthetase
Igni_1113	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Igni_1117	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
Igni_1137	ENOG4105CB5	ATP-dependent DNA helicase recG
Igni_1144	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Igni_1145	ENOG4108RG7	formate hydrogenlyase complex iron-sulfur subunit
Igni_1148	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Igni_1150	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Igni_1155	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Igni_1159	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
Igni_1172	ENOG4107QRT	dEAD DEAH box helicase
Igni_1177	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
Igni_1180	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Igni_1184	ENOG4108K3F	N(2),N(2)-dimethylguanosine tRNA methyltransferase
Igni_1186	ENOG4105CNW	domain protein
Igni_1194	ENOG4108D32	Methyltransferase
Igni_1200	ENOG4105DGU	Histone deacetylase
Igni_1202	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Igni_1205	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
Igni_1207	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
Igni_1208	ENOG4107RDY	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
Igni_1212	ENOG4105CJW	magnesium transporter
Igni_1219	ENOG4105C3K	feS assembly ATPase SufC
Igni_1220	ENOG4105DIW	FeS assembly protein SUFB
Igni_1226	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Igni_1228	ENOG4105C5F	glutamine synthetase
Igni_1248	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Igni_1249	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Igni_1251	ENOG4107JTW	chlorite dismutase
Igni_1252	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
Igni_1254	ENOG4105E8R	UPF0173 metal-dependent hydrolase
Igni_1256	ENOG4105EJ5	oxidoreductase gamma subunit
Igni_1258	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Igni_1259	ENOG4105DDK	oxidoreductase, beta subunit
Igni_1260	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
Igni_1262	ENOG4105S1Z	Stage IV sporulation protein B
Igni_1263	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
Igni_1265	ENOG4105DR4	Methyltransferase
Igni_1267	ENOG4108HHA	Transketolase
Igni_1270	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Igni_1273	ENOG4105D1E	Undecaprenyl pyrophosphate phosphatase
Igni_1274	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Igni_1276	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Igni_1277	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Igni_1280	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Igni_1281	ENOG4108ZJT	translation initiation factor, Sui1
Igni_1293	ENOG4105BZU	Histidine kinase
Igni_1294	ENOG4108YZA	Nitrogen regulatory protein pii
Igni_1299	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Igni_1300	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Igni_1305	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
Igni_1317	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Igni_1319	ENOG4105C2X	Arabinose 5-phosphate isomerase
Igni_1324	ENOG4105D22	carbon starvation protein
Igni_1329	ENOG4105DK0	Indole-3-glycerol phosphate synthase
Igni_1330	ENOG4108JQ7	(ABC) transporter
Igni_1333	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Igni_1335	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
Igni_1337	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Igni_1338	ENOG4105C3U	ABC transporter
Igni_1339	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
Igni_1345	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Igni_1346	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Igni_1347	ENOG4107QRT	dEAD DEAH box helicase
Igni_1348	ENOG4108YZ8	Superoxide reductase
Igni_1349	ENOG4108Q27	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity)
Igni_1361	ENOG4105EVU	fructokinase
Igni_1364	ENOG4108IG5	Transcriptional regulator
Igni_1365	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Igni_1371	ENOG4105CYW	agmatinase
Igni_1374	ENOG4105E3H	phosphoglycerate mutase
Igni_1377	ENOG4105HEE	Binding Domain protein
Igni_1379	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
Igni_1383	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Igni_1385	ENOG4105EYH	Exonuclease
Igni_1387	ENOG4105DBV	ornithine carbamoyltransferase
Igni_1390	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Igni_1391	ENOG4105C4K	Nad synthetase
Igni_1399	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
Igni_1400	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Igni_1403	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Igni_1407	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Igni_1408	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Igni_1409	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Igni_1411	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Igni_1413	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Igni_1414	ENOG4108IJ8	ABC transporter
Igni_1416	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
Igni_1417	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
Igni_1419	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Igni_1422	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
Igni_1430	ENOG4105CH7	arginosuccinase
Igni_1431	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Igni_1435	ENOG4105C5S	asparaginyl-tRNA synthetase
Igni_1436	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
Igni_1440	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
Igni_1442	ENOG4108I0Q	anthranilate phosphoribosyltransferase