locus-tag	class	description
Igni_0001	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Igni_0002	COG0277	FAD linked oxidase domain protein
Igni_0007	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Igni_0009	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Igni_0013	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Igni_0018	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Igni_0020	COG0432	Pfam Uncharacterised protein family UPF0047
Igni_0022	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Igni_0029	COG0140	phosphoribosyl-ATP diphosphatase activity
Igni_0029	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Igni_0030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Igni_0038	COG1129	ABC transporter
Igni_0040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Igni_0041	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Igni_0042	COG0543	2 iron, 2 sulfur cluster binding
Igni_0043	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Igni_0044	COG0540	Belongs to the ATCase OTCase family
Igni_0047	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Igni_0051	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Igni_0056	COG0668	transmembrane transport
Igni_0057	COG0189	ligase activity
Igni_0065	COG0051	transcription antitermination factor activity, RNA binding
Igni_0066	COG1252	NADH dehydrogenase
Igni_0067	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Igni_0067	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Igni_0069	COG0730	response to heat
Igni_0077	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Igni_0079	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Igni_0087	COG1730	sister chromatid segregation
Igni_0089	COG1648	precorrin-2 dehydrogenase activity
Igni_0089	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Igni_0096	COG0459	protein refolding
Igni_0104	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Igni_0107	COG0581	inorganic phosphate transmembrane transporter activity
Igni_0108	COG0573	inorganic phosphate transmembrane transporter activity
Igni_0109	COG1994	Peptidase M50
Igni_0110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Igni_0110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Igni_0118	COG1121	(ABC) transporter
Igni_0122	COG1522	sequence-specific DNA binding
Igni_0127	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Igni_0128	COG2095	MarC family integral membrane protein
Igni_0129	COG1444	tRNA N-acetyltransferase activity
Igni_0132	COG1454	alcohol dehydrogenase
Igni_0146	COG1131	(ABC) transporter
Igni_0150	COG0495	leucyl-tRNA aminoacylation
Igni_0155	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Igni_0156	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Igni_0158	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
Igni_0160	COG2813	Specifically methylates the guanine in position
Igni_0162	COG0303	'Molybdopterin
Igni_0163	COG1136	(ABC) transporter
Igni_0165	COG0151	Belongs to the GarS family
Igni_0168	COG0189	ligase activity
Igni_0171	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Igni_0177	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Igni_0179	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Igni_0180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Igni_0181	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Igni_0182	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Igni_0184	COG0200	Binds to the 23S rRNA
Igni_0185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Igni_0186	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Igni_0188	COG0052	Belongs to the universal ribosomal protein uS2 family
Igni_0191	COG1201	RNA secondary structure unwinding
Igni_0196	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Igni_0198	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Igni_0199	COG0527	aspartate kinase activity
Igni_0201	COG0252	asparaginase activity
Igni_0205	COG0714	Associated with various cellular activities
Igni_0210	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Igni_0215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Igni_0220	COG0525	valine-tRNA ligase activity
Igni_0227	COG0167	dihydroorotate dehydrogenase activity
Igni_0229	COG0602	queuosine metabolic process
Igni_0230	COG1358	cellular component organization or biogenesis
Igni_0231	COG2848	UPF0210 protein
Igni_0233	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Igni_0243	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Igni_0244	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Igni_0249	COG0049	tRNA binding
Igni_0252	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Igni_0255	COG0589	response to stress
Igni_0256	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Igni_0257	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Igni_0260	COG0314	molybdopterin synthase activity
Igni_0261	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Igni_0266	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Igni_0269	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
Igni_0273	COG0402	S-adenosylhomocysteine deaminase activity
Igni_0274	COG0126	phosphoglycerate kinase activity
Igni_0278	COG0420	3'-5' exonuclease activity
Igni_0283	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Igni_0293	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Igni_0294	COG2264	protein methyltransferase activity
Igni_0301	COG1573	uracil-dna glycosylase
Igni_0303	COG3830	Belongs to the UPF0237 family
Igni_0304	COG0066	3-isopropylmalate dehydratase activity
Igni_0306	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Igni_0307	COG0077	Prephenate dehydratase
Igni_0307	COG1605	Chorismate mutase
Igni_0311	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Igni_0313	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Igni_0315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Igni_0324	COG0113	porphobilinogen synthase activity
Igni_0327	COG1337	RAMP superfamily
Igni_0331	COG0504	CTP synthase activity
Igni_0334	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Igni_0340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Igni_0341	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
Igni_0343	COG0483	inositol monophosphate 1-phosphatase activity
Igni_0346	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Igni_0347	COG0180	Tryptophanyl-tRNA synthetase
Igni_0348	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Igni_0354	COG1489	DNA binding
Igni_0362	COG0442	prolyl-tRNA aminoacylation
Igni_0363	COG1980	fructose-bisphosphate aldolase activity
Igni_0368	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Igni_0374	COG0805	protein transport
Igni_0376	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Igni_0383	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Igni_0384	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Igni_0386	COG0045	succinate-CoA ligase (ADP-forming) activity
Igni_0386	COG1042	CoA-binding domain protein
Igni_0386	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Igni_0388	COG0163	prenyltransferase activity
Igni_0392	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Igni_0395	COG0693	protein deglycase activity
Igni_0400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Igni_0401	COG1324	tolerance protein
Igni_0402	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Igni_0406	COG0436	Aminotransferase
Igni_0407	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Igni_0408	COG0069	glutamate synthase activity
Igni_0412	COG0301	tRNA thio-modification
Igni_0413	COG0409	Hydrogenase expression formation protein
Igni_0418	COG1110	DNA topoisomerase II activity
Igni_0420	COG2048	Heterodisulfide reductase, subunit B
Igni_0428	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Igni_0431	COG0159	tryptophan synthase activity
Igni_0436	COG0515	serine threonine protein kinase
Igni_0438	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Igni_0440	COG0463	Glycosyl transferase, family 2
Igni_0448	COG0656	L-ascorbic acid biosynthetic process
Igni_0454	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Igni_0456	COG0589	response to stress
Igni_0457	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Igni_0459	COG0450	alkyl hydroperoxide reductase
Igni_0460	COG1337	RAMP superfamily
Igni_0465	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Igni_0466	COG0512	Glutamine amidotransferase of anthranilate synthase
Igni_0466	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Igni_0472	COG2998	abc-type tungstate transport system, permease component
Igni_0479	COG0577	efflux transmembrane transporter activity
Igni_0479	COG1136	(ABC) transporter
Igni_0483	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Igni_0483	COG1648	precorrin-2 dehydrogenase activity
Igni_0489	COG2267	carboxylic ester hydrolase activity
Igni_0490	COG0309	Hydrogenase expression formation protein (HypE)
Igni_0494	COG1522	sequence-specific DNA binding
Igni_0495	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Igni_0506	COG0037	tRNA processing
Igni_0512	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Igni_0516	COG1110	DNA topoisomerase II activity
Igni_0519	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Igni_0521	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Igni_0531	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Igni_0532	COG0430	RNA-3'-phosphate cyclase activity
Igni_0536	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Igni_0539	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Igni_0543	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Igni_0546	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Igni_0550	COG1122	ATPase activity
Igni_0554	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Igni_0559	COG1058	Belongs to the CinA family
Igni_0559	COG1546	Belongs to the CinA family
Igni_0560	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Igni_0564	COG0589	response to stress
Igni_0568	COG0423	glycine-tRNA ligase activity
Igni_0570	COG0367	asparagine synthase
Igni_0571	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Igni_0573	COG0531	amino acid
Igni_0578	COG1214	PFAM Peptidase M22, glycoprotease
Igni_0578	COG0456	acetyltransferase
Igni_0580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Igni_0582	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Igni_0585	COG0756	dUTP diphosphatase activity
Igni_0586	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Igni_0587	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Igni_0588	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Igni_0589	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Igni_0590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Igni_0591	COG0255	Belongs to the universal ribosomal protein uL29 family
Igni_0596	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Igni_0598	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Igni_0598	COG0517	IMP dehydrogenase activity
Igni_0600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Igni_0601	COG1245	4Fe-4S binding domain
Igni_0601	COG2878	Part of a membrane complex involved in electron transport
Igni_0604	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Igni_0606	COG2078	PFAM AMMECR1 domain protein
Igni_0607	COG0704	Plays a role in the regulation of phosphate uptake
Igni_0608	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Igni_0611	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Igni_0617	COG0492	ferredoxin-NADP+ reductase activity
Igni_0620	COG0431	NADPH-dependent FMN reductase
Igni_0621	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Igni_0622	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Igni_0628	COG1063	alcohol dehydrogenase
Igni_0630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Igni_0631	COG1899	peptidyl-lysine modification to peptidyl-hypusine
Igni_0632	COG0302	gtp cyclohydrolase
Igni_0633	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Igni_0635	COG0137	argininosuccinate synthase activity
Igni_0637	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Igni_0637	COG0519	Catalyzes the synthesis of GMP from XMP
Igni_0645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Igni_0648	COG0517	IMP dehydrogenase activity
Igni_0648	COG0516	GMP reductase activity
Igni_0649	COG0647	UMP catabolic process
Igni_0651	COG0085	RNA polymerase activity
Igni_0655	COG0516	GMP reductase activity
Igni_0664	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Igni_0671	COG0446	pyridine nucleotide-disulphide oxidoreductase
Igni_0679	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Igni_0683	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Igni_0684	COG0181	hydroxymethylbilane synthase activity
Igni_0686	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Igni_0690	COG0417	DNA replication proofreading
Igni_0691	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Igni_0691	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Igni_0693	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Igni_0696	COG2022	thiamine diphosphate biosynthetic process
Igni_0704	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Igni_0705	COG0492	ferredoxin-NADP+ reductase activity
Igni_0706	COG1522	sequence-specific DNA binding
Igni_0707	COG0037	tRNA processing
Igni_0725	COG0105	UTP biosynthetic process
Igni_0728	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Igni_0732	COG0410	ABC transporter
Igni_0733	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Igni_0738	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Igni_0741	COG3206	protein involved in exopolysaccharide biosynthesis
Igni_0741	COG0489	protein tyrosine kinase activity
Igni_0747	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Igni_0752	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Igni_0754	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Igni_0756	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Igni_0757	COG0489	protein tyrosine kinase activity
Igni_0758	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Igni_0766	COG0563	adenylate kinase activity
Igni_0773	COG0107	imidazoleglycerol-phosphate synthase activity
Igni_0775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Igni_0788	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Igni_0799	COG0501	Belongs to the peptidase M48B family
Igni_0801	COG0437	4 iron, 4 sulfur cluster binding
Igni_0802	COG0243	molybdopterin cofactor binding
Igni_0805	COG0131	Imidazoleglycerol-phosphate dehydratase
Igni_0818	COG0116	Belongs to the methyltransferase superfamily
Igni_0818	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Igni_0829	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Igni_0843	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Igni_0853	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Igni_0857	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Igni_0859	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Igni_0860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Igni_0867	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Igni_0868	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Igni_0872	COG1702	phosphate starvation-inducible protein PhoH
Igni_0873	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Igni_0875	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Igni_0877	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Igni_0879	COG0124	histidyl-tRNA synthetase
Igni_0880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Igni_0885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Igni_0886	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Igni_0888	COG0351	phosphomethylpyrimidine kinase
Igni_0888	COG1992	Thiamine-phosphate synthase
Igni_0889	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Igni_0891	COG3958	Transketolase
Igni_0892	COG1605	Chorismate mutase
Igni_0892	COG0077	Prephenate dehydratase
Igni_0900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Igni_0900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Igni_0902	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Igni_0904	COG0301	tRNA thio-modification
Igni_0909	COG0312	modulator of DNA gyrase
Igni_0911	COG0492	ferredoxin-NADP+ reductase activity
Igni_0916	COG0154	amidase activity
Igni_0921	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Igni_0924	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Igni_0925	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Igni_0931	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Igni_0934	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Igni_0936	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Igni_0938	COG0495	leucyl-tRNA aminoacylation
Igni_0942	COG1793	dna ligase
Igni_0944	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Igni_0946	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Igni_0948	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Igni_0949	COG2151	metal-sulfur cluster biosynthetic enzyme
Igni_0956	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Igni_0956	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Igni_0960	COG1151	hydroxylamine reductase activity
Igni_0962	COG2409	Drug exporters of the RND superfamily
Igni_0963	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Igni_0964	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Igni_0966	COG0089	rRNA binding
Igni_0970	COG2046	Belongs to the sulfate adenylyltransferase family
Igni_0975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Igni_0980	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Igni_0982	COG0473	3-isopropylmalate dehydrogenase activity
Igni_0983	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Igni_0990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Igni_0991	COG0215	cysteine-tRNA ligase activity
Igni_0992	COG1355	regulation of microtubule-based process
Igni_1002	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Igni_1007	COG0148	phosphopyruvate hydratase activity
Igni_1017	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Igni_1021	COG4166	transmembrane transport
Igni_1027	COG1522	sequence-specific DNA binding
Igni_1037	COG1234	tRNA 3'-trailer cleavage
Igni_1040	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Igni_1040	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Igni_1044	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Igni_1046	COG0402	S-adenosylhomocysteine deaminase activity
Igni_1047	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Igni_1056	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Igni_1056	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Igni_1058	COG1250	3-hydroxyacyl-CoA dehydrogenase
Igni_1062	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Igni_1064	COG0538	isocitrate dehydrogenase activity
Igni_1068	COG2442	InterPro IPR007367
Igni_1077	COG1013	pyruvate-flavodoxin oxidoreductase activity
Igni_1078	COG0674	pyruvate-flavodoxin oxidoreductase activity
Igni_1079	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Igni_1084	COG1668	transmembrane transport
Igni_1085	COG1131	(ABC) transporter
Igni_1086	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Igni_1087	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Igni_1091	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Igni_1092	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Igni_1094	COG0517	IMP dehydrogenase activity
Igni_1094	COG0516	GMP reductase activity
Igni_1097	COG0028	Belongs to the TPP enzyme family
Igni_1099	COG0537	adenosine 5'-monophosphoramidase activity
Igni_1100	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Igni_1102	COG0626	cystathionine gamma-synthase activity
Igni_1103	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Igni_1107	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Igni_1108	COG0644	oxidoreductase
Igni_1110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Igni_1113	COG0574	Belongs to the PEP-utilizing enzyme family
Igni_1113	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Igni_1137	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Igni_1144	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Igni_1145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Igni_1148	COG1007	ATP synthesis coupled electron transport
Igni_1150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Igni_1155	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Igni_1159	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Igni_1172	COG1201	RNA secondary structure unwinding
Igni_1177	COG0552	protein localization to endoplasmic reticulum
Igni_1180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Igni_1184	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
Igni_1186	COG1773	rubredoxin
Igni_1186	COG0426	domain, Protein
Igni_1194	COG2226	methyltransferase
Igni_1202	COG0315	cyclic pyranopterin monophosphate synthase activity
Igni_1205	COG1192	Involved in chromosome partitioning
Igni_1207	COG1335	isochorismatase
Igni_1208	COG0083	homoserine kinase activity
Igni_1212	COG2239	Acts as a magnesium transporter
Igni_1219	COG0396	ATPase activity
Igni_1220	COG0719	Fe-S assembly protein
Igni_1226	COG0072	phenylalanine-tRNA ligase activity
Igni_1226	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Igni_1248	COG0066	3-isopropylmalate dehydratase activity
Igni_1249	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Igni_1252	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Igni_1254	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Igni_1256	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Igni_1258	COG0674	pyruvate-flavodoxin oxidoreductase activity
Igni_1259	COG1013	pyruvate-flavodoxin oxidoreductase activity
Igni_1260	COG0585	pseudouridine synthase activity
Igni_1262	COG0750	zinc metalloprotease
Igni_1263	COG0039	L-malate dehydrogenase activity
Igni_1265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Igni_1267	COG3959	Transketolase, thiamine diphosphate binding domain
Igni_1270	COG1136	(ABC) transporter
Igni_1273	COG0671	phosphoesterase, PA-phosphatase related
Igni_1274	COG0200	Binds to the 23S rRNA
Igni_1276	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Igni_1277	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Igni_1280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Igni_1281	COG0023	Translation Initiation Factor
Igni_1284	COG0561	phosphatase activity
Igni_1293	COG0004	ammonium transporteR
Igni_1294	COG0347	Belongs to the P(II) protein family
Igni_1299	COG2255	four-way junction helicase activity
Igni_1300	COG2255	four-way junction helicase activity
Igni_1305	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Igni_1317	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Igni_1317	COG0072	phenylalanine-tRNA ligase activity
Igni_1319	COG0517	IMP dehydrogenase activity
Igni_1319	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Igni_1324	COG1966	Carbon starvation protein
Igni_1329	COG0134	indole-3-glycerol-phosphate synthase activity
Igni_1330	COG4608	Belongs to the ABC transporter superfamily
Igni_1333	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Igni_1336	COG0601	transmembrane transport
Igni_1338	COG0444	Belongs to the ABC transporter superfamily
Igni_1345	COG0519	Catalyzes the synthesis of GMP from XMP
Igni_1345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Igni_1346	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Igni_1347	COG1201	RNA secondary structure unwinding
Igni_1348	COG2033	superoxide reductase activity
Igni_1349	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
Igni_1361	COG1940	carbohydrate kinase activity
Igni_1364	COG1309	transcriptional regulator
Igni_1374	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Igni_1377	COG0348	domain, Protein
Igni_1379	COG0243	molybdopterin cofactor binding
Igni_1383	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Igni_1385	COG0419	ATPase involved in DNA repair
Igni_1387	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Igni_1390	COG0303	'Molybdopterin
Igni_1391	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Igni_1399	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Igni_1400	COG0505	Belongs to the CarA family
Igni_1401	COG0183	Belongs to the thiolase family
Igni_1403	COG0189	ligase activity
Igni_1407	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Igni_1408	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Igni_1409	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Igni_1411	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Igni_1413	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Igni_1414	COG0517	IMP dehydrogenase activity
Igni_1414	COG1125	glycine betaine transport
Igni_1416	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Igni_1419	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Igni_1422	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Igni_1430	COG0165	Argininosuccinate lyase
Igni_1431	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Igni_1435	COG0017	Asparaginyl-tRNA synthetase
Igni_1436	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Igni_1440	COG1988	membrane-bound metal-dependent
Igni_1442	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)