locus-tag class description GIY02_00035 ENOG4105GVR general secretion pathway protein D GIY02_00035 ENOG4105GVR general secretion pathway protein D GIY02_00095 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) GIY02_00105 ENOG4105BZU Histidine kinase GIY02_00120 ENOG4105JHE Major Facilitator Superfamily GIY02_00135 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain GIY02_00140 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GIY02_00145 ENOG4105VPI YqaE family transport protein GIY02_00150 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GIY02_00155 ENOG4107EFN gluconate transport system permease 3 GIY02_00175 ENOG4105C28 cystathionine GIY02_00185 ENOG4108YDI single-species biofilm formation on inanimate substrate GIY02_00195 ENOG4108QY0 Membrane GIY02_00200 ENOG4108N8X transition metal ion binding GIY02_00205 ENOG4108Z9Z response to DNA damage stimulus GIY02_00215 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GIY02_00225 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GIY02_00240 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions GIY02_00245 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GIY02_00255 ENOG4105D01 (LipO)protein GIY02_00265 ENOG4108UMI ABC transporter, permease GIY02_00270 ENOG4105EA8 2-Nitropropane dioxygenase GIY02_00275 ENOG4105EGI Transcriptional regulator GIY02_00280 ENOG4105CBP Major Facilitator GIY02_00285 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GIY02_00290 ENOG4105T38 integral membrane protein GIY02_00300 ENOG4105F9N Major Facilitator Superfamily GIY02_00320 ENOG4105MVE transcriptional regulator GIY02_00325 ENOG4105G63 Type III effector Hrp-dependent GIY02_00330 ENOG4105FB2 class II Aldolase GIY02_00335 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GIY02_00340 ENOG4105CSP Major Facilitator Superfamily GIY02_00345 ENOG4105EXW epimerase dehydratase GIY02_00370 ENOG4105BZU Histidine kinase GIY02_00375 ENOG4105M0C cytoplasmic protein GIY02_00380 ENOG4105CSV Glutaminase GIY02_00385 ENOG4105C26 Dehydrogenase GIY02_00395 ENOG4105MVE transcriptional regulator GIY02_00400 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GIY02_00405 ENOG4107S2N Type III effector Hrp-dependent GIY02_00410 ENOG4105C0A alcohol dehydrogenase GIY02_00415 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GIY02_00435 ENOG4105CHR reductase GIY02_00440 ENOG4105JAB phenazine biosynthesis protein, phzf family GIY02_00445 ENOG4105F27 Major Facilitator GIY02_00455 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GIY02_00465 ENOG4106DNR multiple antibiotic resistance protein GIY02_00470 ENOG4108594 Permease of the drug metabolite transporter GIY02_00475 ENOG4105E5W Transporter GIY02_00510 ENOG410620I Diguanylate cyclase GIY02_00520 ENOG4105ETE Transcriptional regulator (LacI family GIY02_00525 ENOG4105CNT hydrolase family 2 GIY02_00530 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GIY02_00535 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GIY02_00545 ENOG4105DGW oligopeptidase A GIY02_00550 ENOG4105EMU Dehydrogenase GIY02_00555 ENOG4107XBN GntR Family Transcriptional Regulator GIY02_00560 ENOG4108U51 Universal stress protein GIY02_00565 ENOG4105DEI Mannitol dehydrogenase GIY02_00575 ENOG4105CPQ Dehydrogenase GIY02_00580 ENOG4105CXK mandelate racemase muconate lactonizing GIY02_00585 ENOG4108I5G Major Facilitator superfamily GIY02_00590 ENOG4105KK4 UPF0060 membrane protein GIY02_00600 ENOG4108MK9 spermidine N(1)-acetyltransferase GIY02_00610 ENOG4105KBG Protein of unknown function (DUF1161) GIY02_00620 ENOG4105QAX Iron-sulfur GIY02_00625 ENOG4107KGK dmso reductase anchor subunit GIY02_00630 ENOG4108NEM leader-binding protein dmsD GIY02_00635 ENOG4105CMQ Chloride channel GIY02_00640 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GIY02_00645 ENOG4105DAG ROK family GIY02_00650 ENOG4106NZI LysR family Transcriptional regulator GIY02_00655 ENOG4105D94 Major Facilitator Superfamily GIY02_00660 ENOG4105CTD carboxy-peptidase GIY02_00680 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap GIY02_00690 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) GIY02_00695 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) GIY02_00705 ENOG4105DSF transport protein GIY02_00735 ENOG4107TT2 Auxin Efflux Carrier GIY02_00740 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase GIY02_00745 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GIY02_00750 ENOG4108K70 Transcriptional regulator GIY02_00755 ENOG4105DWT malate dehydrogenase (quinone) GIY02_00760 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GIY02_00765 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GIY02_00770 ENOG4108MRH transcriptional regulatory protein GIY02_00795 ENOG4107GFK fumarate GIY02_00805 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GIY02_00810 ENOG4105F2Z 3-oxoadipate enol-lactonase GIY02_00815 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase GIY02_00820 ENOG4105CHU acetyl-coa acetyltransferase GIY02_00825 ENOG4107QNJ CoA-transferase subunit B GIY02_00835 ENOG4107HP6 Transcriptional regulator GIY02_00840 ENOG4108DG9 Smr protein MutS2 GIY02_00845 ENOG4106KR7 LysR family Transcriptional regulator GIY02_00855 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B GIY02_00860 ENOG4105CFC Transporter GIY02_00865 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GIY02_00870 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GIY02_00875 ENOG4105Q9Y Universal stress protein GIY02_00880 ENOG410671Z uncharacterized protein ydiH GIY02_00885 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GIY02_00890 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GIY02_00895 ENOG4105C5D exported protein GIY02_00900 ENOG4105D5Q Arginine ornithine antiporter GIY02_00905 ENOG410642E Short chain dehydrogenase GIY02_00910 ENOG4105RA2 Membrane GIY02_00915 ENOG4107EXC regulatoR GIY02_00995 ENOG4107R08 Integrase GIY02_01000 ENOG4105JJR Histidine kinase GIY02_01010 ENOG4105C9Q fumarate hydratase class II GIY02_01020 ENOG4107GFK fumarate GIY02_01025 ENOG4105EIP mannose-6-phosphate isomerase GIY02_01030 ENOG4106J39 exported protein GIY02_01035 ENOG4107P2S Transcriptional regulator GIY02_01040 ENOG4105CI1 PTS System GIY02_01045 ENOG4105C87 Aminotransferase class I and II GIY02_01050 ENOG41061EV selenium-binding protein YdfZ GIY02_01055 ENOG41066VF YeeE YedE family protein GIY02_01060 ENOG4105KSU Redox protein GIY02_01070 ENOG4108Z6Z Transcriptional regulator GIY02_01075 ENOG4105D01 (LipO)protein GIY02_01080 ENOG41064WM Uncharacterized protein YcgX GIY02_01090 ENOG4105D9R oxidoreductase GIY02_01100 ENOG4105CS2 ec 3.2.1.21 GIY02_01110 ENOG4105M9B inner membrane protein ydgK GIY02_01135 ENOG4108UQQ Electron transport complex GIY02_01145 ENOG4105CSM endonuclease III GIY02_01160 ENOG4108K3A Glutathione S-transferase GIY02_01165 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) GIY02_01170 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GIY02_01180 ENOG410642K Lysozyme inhibitor GIY02_01190 ENOG4108XTF Outer Membrane Lipoprotein GIY02_01195 ENOG4105BZU Histidine kinase GIY02_01210 ENOG4105Y49 secretion protein, HlyD family GIY02_01215 ENOG4105DSW Fusaric acid resistance protein GIY02_01220 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GIY02_01225 ENOG4107RGM aldo keto reductase GIY02_01230 ENOG4105XZD Fe-S protein GIY02_01235 ENOG4108WUH Transcriptional regulator, TetR family GIY02_01240 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GIY02_01245 ENOG4108UYE Lactoylglutathione lyase GIY02_01250 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) GIY02_01255 ENOG4105M2J Glutaredoxin GIY02_01260 ENOG4105K4H Nlp p60 protein GIY02_01265 ENOG41086D8 Transcriptional regulator GIY02_01270 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GIY02_01275 ENOG4105F27 Major Facilitator GIY02_01290 ENOG4105F52 Transcriptional regulator GIY02_01295 ENOG4105CZQ inner membrane transport protein YdhC GIY02_01300 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GIY02_01305 ENOG4108R6K riboflavin synthase, subunit alpha GIY02_01310 ENOG4107QI1 Mate efflux family protein GIY02_01315 ENOG4108URH decarboxylase GIY02_01365 ENOG4107B2H carbonic anhydrase GIY02_01380 ENOG4108JUB Transcriptional regulator GIY02_01385 ENOG4105IW6 Carbamoyltransferase GIY02_01390 ENOG4107RCH Diaminopropionate ammonia-lyase GIY02_01395 ENOG4107S4Y M20 DapE family protein YgeY GIY02_01405 ENOG4105C5B carbamate kinase GIY02_01410 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family GIY02_01415 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC GIY02_01440 ENOG4106NZI LysR family Transcriptional regulator GIY02_01450 ENOG4107QNJ CoA-transferase subunit B GIY02_01455 ENOG4105CHU acetyl-coa acetyltransferase GIY02_01460 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) GIY02_01465 ENOG4105CY2 Citrate transporter GIY02_01470 ENOG4105DTD Dehydrogenase GIY02_01490 ENOG4105C7K acetolactate synthase GIY02_01495 ENOG4105CHR reductase GIY02_01500 ENOG4105DA4 cytochrome c-type biogenesis protein GIY02_01530 ENOG4107Z33 ABC transporter, permease GIY02_01550 ENOG4105DG4 malate L-lactate dehydrogenase GIY02_01555 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GIY02_01595 ENOG4105K5X acetyltransferase GIY02_01600 ENOG4108JCI Transcriptional regulator GIY02_01605 ENOG4105CVJ phosphoglycerate mutase GIY02_01630 ENOG4108UQ8 endoribonuclease L-psp GIY02_01655 ENOG4105C26 Dehydrogenase GIY02_01660 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GIY02_01665 ENOG4105RPH Inner membrane protein YddG GIY02_01670 ENOG4105C54 Major Facilitator superfamily GIY02_01685 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GIY02_01690 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GIY02_01700 ENOG4108MEJ flavin reductase domain protein GIY02_01720 ENOG4105ENX hydrolase GIY02_01725 ENOG4107RTG Major Facilitator superfamily GIY02_01730 ENOG4105EQ2 LysR family Transcriptional regulator GIY02_01735 ENOG4105D29 Helix-turn-helix type 11 domain protein GIY02_01740 ENOG4105CHR reductase GIY02_01745 ENOG4105EWC Purine nucleoside phosphorylase GIY02_01750 ENOG4105CH2 amidohydrolase GIY02_01760 ENOG4105CDA abc transporter atp-binding protein GIY02_01765 ENOG4105E5Q amino acid AbC transporter GIY02_01770 ENOG4106PMH Extracellular solute-binding protein family 3 GIY02_01790 ENOG4105DQ5 transport system permease protein GIY02_01795 ENOG4105E0A ABC, transporter GIY02_01805 ENOG4108IY8 ABC, transporter GIY02_01810 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GIY02_01830 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GIY02_01835 ENOG4105EJC lysr family transcriptional regulator GIY02_01840 ENOG4108T2C cysteine dioxygenase type I GIY02_01860 ENOG4105S10 periplasmic binding protein GIY02_01865 ENOG4105EHG Permease protein GIY02_01870 ENOG4108W0P ABC transporter GIY02_01875 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein GIY02_01880 ENOG4105E2X shikimate dehydrogenase GIY02_01885 ENOG4105DJB Major Facilitator Superfamily GIY02_01900 ENOG4105RFR Protein of unknown function (DUF2767) GIY02_01905 ENOG4105CA9 Pyruvate kinase GIY02_01915 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GIY02_01920 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GIY02_01930 ENOG4105JRK feS assembly protein SufD GIY02_01935 ENOG4105C3K feS assembly ATPase SufC GIY02_01940 ENOG4105DIW FeS assembly protein SUFB GIY02_01945 ENOG4108Z4V iron-sulfur cluster assembly GIY02_01970 ENOG4105Y3U Transglycosylase-associated protein GIY02_01975 ENOG4105KWI UPF0339 protein GIY02_01980 ENOG4105KA0 thioesterase Superfamily protein GIY02_01985 ENOG4105CQB FAD linked oxidase domain protein GIY02_01990 ENOG4105IPI Membrane GIY02_02000 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GIY02_02015 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GIY02_02020 ENOG4106EDX Hemin uptake protein GIY02_02030 ENOG4108QBX (LipO)protein GIY02_02035 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) GIY02_02040 ENOG4108V06 Glutathione peroxidase GIY02_02045 ENOG4105D01 (LipO)protein GIY02_02050 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) GIY02_02060 ENOG4105RQF LysR family Transcriptional regulator GIY02_02065 ENOG4105MWK D-amino acid dehydrogenase, small subunit GIY02_02080 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GIY02_02085 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GIY02_02095 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GIY02_02105 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GIY02_02115 ENOG4108NE3 Salt-induced outer membrane protein GIY02_02120 ENOG4105DE4 1-phosphofructokinase GIY02_02125 ENOG4105P10 Uncharacterized protein ydiZ GIY02_02130 ENOG4105FGM Fructosamine kinase GIY02_02135 ENOG410822N TonB family GIY02_02140 ENOG4105K9H YciI-like protein GIY02_02150 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GIY02_02160 ENOG4105EYW Ion transport protein GIY02_02165 ENOG4108JQ7 (ABC) transporter GIY02_02170 ENOG4105C3U ABC transporter GIY02_02175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GIY02_02185 ENOG4107QSI ABC, transporter GIY02_02190 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GIY02_02195 ENOG4108EKI Dehydrogenase GIY02_02205 ENOG4108SAU DNA-binding protein H-ns GIY02_02210 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GIY02_02215 ENOG4105I93 response regulator GIY02_02220 ENOG4105D78 K07001 NTE family protein GIY02_02230 ENOG4105CIY formyltetrahydrofolate deformylase GIY02_02290 ENOG41076YT nitrate reductase, gamma subunit GIY02_02295 ENOG4105R3A Nitrate reductase GIY02_02300 ENOG4108IUE nitrate reductase beta subunit GIY02_02305 ENOG4105CRU nitrate reductase, alpha subunit GIY02_02310 ENOG4105DQQ Major facilitator superfamily MFS_1 GIY02_02315 ENOG4105BZU Histidine kinase GIY02_02320 ENOG4105WH1 Two component transcriptional regulator luxr family GIY02_02325 ENOG4105ID0 Putative invasin GIY02_02335 ENOG4107QZF nitrite reductase NADPH large subunit GIY02_02340 ENOG4105D7T ABC transporter GIY02_02360 ENOG41090EX DsrE family GIY02_02370 ENOG4108NH8 Cation transport protein GIY02_02380 ENOG4105WS7 Cation transport regulator GIY02_02385 ENOG4105EWV Sodium calcium exchanger membrane region GIY02_02395 ENOG41063JG Transcriptional regulator GIY02_02400 ENOG4108YY7 Invasion gene expression up-regulator SirB GIY02_02405 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GIY02_02415 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GIY02_02430 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GIY02_02435 ENOG4105CHH sulfate transporter GIY02_02440 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria GIY02_02450 ENOG4105C3G gtp-binding protein GIY02_02455 ENOG4105R3P Inner membrane protein yagU GIY02_02465 ENOG4105DTA methyltransferase GIY02_02470 ENOG4105YCT UPF0386 protein GIY02_02475 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme GIY02_02500 ENOG4105C1P efflux transporter, rnd family, mfp subunit GIY02_02505 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF GIY02_02515 ENOG4108XDN Transcriptional regulator GIY02_02520 ENOG4107SEY Conserved Protein GIY02_02525 ENOG4105N1F Hnh endonuclease GIY02_02535 ENOG4108HMX isocitrate dehydrogenase (NADP) GIY02_02540 ENOG4108R99 pseudouridine synthase GIY02_02560 ENOG4107QTF adenylosuccinate lyase GIY02_02575 ENOG4105EZE Cupin 4 family protein GIY02_02580 ENOG4108UK5 Transposase GIY02_02595 ENOG4105F38 ABC transporter, permease GIY02_02600 ENOG4105D38 putrescine abc transporter GIY02_02605 ENOG4107RUE extracellular solute-binding protein family 1 GIY02_02610 ENOG4105CEY Amp-dependent synthetase and ligase GIY02_02620 ENOG4105CV1 Transketolase (EC 2.2.1.1) GIY02_02625 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GIY02_02630 ENOG4108YZG isomerase GIY02_02635 ENOG4105VI0 Pts system, glucitol sorbitol-specific GIY02_02650 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) GIY02_02655 ENOG4105G63 Type III effector Hrp-dependent GIY02_02670 ENOG4105DKT Transcriptional regulator GIY02_02675 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GIY02_02680 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) GIY02_02685 ENOG4105D60 lipoprotein releasing system transmembrane protein GIY02_02695 ENOG4105D60 lipoprotein releasing system transmembrane protein GIY02_02700 ENOG4108JA2 transcriptioN-repair coupling factor GIY02_02705 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GIY02_02710 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction GIY02_02715 ENOG4108IND Tetr family transcriptional regulator GIY02_02725 ENOG4107MBR 17 kDa surface antigen GIY02_02730 ENOG4105CEP NADH dehydrogenase GIY02_02740 ENOG4105D0Y UPF0227 protein GIY02_02750 ENOG4108RUM thiamine kinase GIY02_02755 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) GIY02_02760 ENOG41090DQ Lipoprotein GIY02_02765 ENOG4105K59 histidine triad (HIT) protein GIY02_02770 ENOG4105CI1 PTS System GIY02_02775 ENOG4105F8V Hydrolase, tatD family GIY02_02780 ENOG4107QRG dna polymerase iii GIY02_02785 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GIY02_02790 ENOG4105HHA aminodeoxychorismate lyase GIY02_02795 ENOG4105YAZ 4-amino-4-deoxychorismate lyase GIY02_02800 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GIY02_02805 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GIY02_02810 ENOG4105CHR reductase GIY02_02815 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GIY02_02820 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GIY02_02825 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GIY02_02835 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein GIY02_02840 ENOG4108UHJ MAF-like protein GIY02_02845 ENOG4105EI2 Pseudouridine synthase GIY02_02850 ENOG4107QQB Ribonuclease E GIY02_02855 ENOG4105EJC lysr family transcriptional regulator GIY02_02865 ENOG4105CJR Integral membrane protein (MviN GIY02_02870 ENOG4105EP9 oxidoreductase GIY02_02875 ENOG4108YXG UPF0502 protein GIY02_02880 ENOG4105D9U N-acetyltransferase GIY02_02890 ENOG4105F3T (LipO)protein GIY02_02900 ENOG4105MEA DNA damage-inducible protein i GIY02_02905 ENOG4105PVA Biofilm formation regulatory protein BssS GIY02_02910 ENOG4105F76 Sarcosine oxidase GIY02_02915 ENOG4106974 biofilm formation GIY02_02925 ENOG4105D1S lipid A biosynthesis GIY02_02935 ENOG4108W47 Acidic protein msyB GIY02_02940 ENOG4105NAC (LipO)protein GIY02_02955 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) GIY02_02975 ENOG4108UQ5 membrane protein YcdZ GIY02_02980 ENOG4107XHZ cytoplasmic chaperone TorD family protein GIY02_03005 ENOG4105HEI LysR family (Transcriptional regulator GIY02_03010 ENOG4105EUB pirin domain protein GIY02_03015 ENOG4105CHJ isochorismatase hydrolase GIY02_03025 ENOG4105D5M phosphate starvation-inducible protein GIY02_03030 ENOG4105DBE peroxidase GIY02_03035 ENOG410650H (LipO)protein GIY02_03040 ENOG4105EKT )-iron permease GIY02_03045 ENOG4105D9N nucleoside GIY02_03055 ENOG4105IPI Membrane GIY02_03060 ENOG4105CK7 Sodium proline symporter GIY02_03065 ENOG4105C26 Dehydrogenase GIY02_03075 ENOG4108R86 Transcriptional regulator GIY02_03085 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) GIY02_03095 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GIY02_03100 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) GIY02_03110 ENOG4105C2W permease GIY02_03120 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 GIY02_03130 ENOG4105XH3 GIY02_03135 ENOG4105D6F Phosphatase GIY02_03180 ENOG4105CUB amino acid GIY02_03185 ENOG4105CFQ glutamine synthetase GIY02_03190 ENOG4108Z86 Glutamine amidotransferase GIY02_03195 ENOG4107VRI Transcriptional regulator GIY02_03200 ENOG4105C26 Dehydrogenase GIY02_03205 ENOG4105CJP fad dependent oxidoreductase GIY02_03210 ENOG4108JPW Aminotransferase GIY02_03215 ENOG4105EJC lysr family transcriptional regulator GIY02_03220 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GIY02_03225 ENOG4105C94 Transporter GIY02_03230 ENOG4105DVW rieske (2Fe-2S) GIY02_03235 ENOG4105C26 Dehydrogenase GIY02_03240 ENOG4105E3J oxidoreductase GIY02_03265 ENOG41067XB TonB family GIY02_03270 ENOG41063SR receptor GIY02_03280 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GIY02_03295 ENOG4105DTS flagellar hook-associated GIY02_03300 ENOG4105MQ3 flagellar protein FliS GIY02_03305 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) GIY02_03325 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GIY02_03330 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GIY02_03335 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GIY02_03340 ENOG41090PJ Flagellar assembly protein GIY02_03345 ENOG4108JIR Flagellum-specific ATP synthase GIY02_03350 ENOG4105GSA Flagellar export protein flij GIY02_03355 ENOG4105WF4 Flagellar hook-length control protein GIY02_03360 ENOG4107ZI8 flagellar basal body-associated protein flil GIY02_03365 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GIY02_03370 ENOG4105DD5 Flagellar motor switch protein GIY02_03380 ENOG4105CN7 Flagellar biosynthetic protein FliP GIY02_03385 ENOG4105VS8 Flagellar biosynthetic protein fliq GIY02_03390 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GIY02_03425 ENOG4105JSC dimethylmenaquinone methyltransferase GIY02_03430 ENOG4107258 Transcriptional regulator GIY02_03440 ENOG4107RGD Major Facilitator superfamily GIY02_03450 ENOG4105F27 Major Facilitator GIY02_03470 ENOG4105DTJ flagellar hook-associated protein GIY02_03475 ENOG4105E1Q flagellar hook-associated protein GIY02_03480 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GIY02_03495 ENOG4105CGA flagellar basal-body rod protein FlgG GIY02_03500 ENOG4108KPB Flagellar basal-body rod protein FlgF GIY02_03530 ENOG4105W00 Flagellar hook capping protein GIY02_03535 ENOG4108ZC9 flagellar basal-body rod protein flgc GIY02_03545 ENOG4105CKS Flagella basal body P-ring formation protein flgA GIY02_03550 ENOG4105M9M anti-sigma28 factor FlgM GIY02_03555 ENOG4105QVD Flagella synthesis protein FlgN GIY02_03570 ENOG4105D00 flagellar biosynthetic protein flhB GIY02_03575 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) GIY02_03580 ENOG4108VYJ response regulator receiver protein GIY02_03590 ENOG4105BZU Histidine kinase GIY02_03595 ENOG4105C8Q Methyl-accepting chemotaxis GIY02_03600 ENOG4105C8Q Methyl-accepting chemotaxis GIY02_03605 ENOG4108V3W Chemotaxis protein, CheW GIY02_03610 ENOG4105CBS Chea signal transduction histidine kinase GIY02_03615 ENOG4105ER2 Ompa motb domain protein GIY02_03620 ENOG4107RD7 Flagellar Motor Protein, MotA GIY02_03630 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) GIY02_03635 ENOG4105D7K pfkb domain protein GIY02_03645 ENOG4108HKT sucrose-6-phosphate hydrolase GIY02_03650 ENOG4105WBN Transcriptional regulator (LacI family GIY02_03655 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) GIY02_03660 ENOG4107B2H carbonic anhydrase GIY02_03665 ENOG4105DND Transcriptional regulator GIY02_03680 ENOG4105HEI LysR family (Transcriptional regulator GIY02_03715 ENOG4108MN8 Membrane GIY02_03725 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 GIY02_03735 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) GIY02_03755 ENOG4108JJA ABC, transporter GIY02_03770 ENOG4105K4P CoA-binding domain protein GIY02_03780 ENOG41088T4 Helicase IV GIY02_03785 ENOG410901E Membrane GIY02_03790 ENOG4105EM2 membrane GIY02_03795 ENOG4108RZ1 DNA transformation protein GIY02_03800 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) GIY02_03805 ENOG4105UYK outer membrane protein a GIY02_03810 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) GIY02_03815 ENOG4105DAN ATP-dependent protease GIY02_03825 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) GIY02_03830 ENOG4108Q2G (LipO)protein GIY02_03835 ENOG4105DY2 Paraquat-inducible protein b GIY02_03840 ENOG4105F1S paraquat-inducible protein a GIY02_03845 ENOG4105C5H ABC transporter GIY02_03855 ENOG4105QVC MOSC domain-containing protein GIY02_03860 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) GIY02_03870 ENOG4108UZX fmn reductase GIY02_03875 ENOG4105GVF (ABC) transporter GIY02_03880 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GIY02_03885 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GIY02_03895 ENOG4105CD8 aminopeptidase N GIY02_03900 ENOG4107RH7 Nicotinate phosphoribosyltransferase GIY02_03905 ENOG4105C5S asparaginyl-tRNA synthetase GIY02_03910 ENOG4105ZIT Porin Gram-negative type GIY02_03915 ENOG4105CGF Aromatic amino acid aminotransferase GIY02_03920 ENOG4105C5X domain protein GIY02_03925 ENOG4105EAQ (twin-arginine translocation) pathway signal GIY02_03930 ENOG4105DIT ErfK YbiS YcfS YnhG family protein GIY02_03940 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) GIY02_03945 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) GIY02_03950 ENOG4106371 Methyltransferase GIY02_03955 ENOG4107S90 membrAne GIY02_03960 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups GIY02_03965 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) GIY02_03970 ENOG4105W49 UPF0434 protein GIY02_03975 ENOG4105T0Z Conserved Protein GIY02_03980 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) GIY02_03985 ENOG4105BZ1 (ABC) transporter GIY02_03990 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GIY02_04000 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GIY02_04005 ENOG4105CAT Cytidine monophosphate kinase GIY02_04015 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GIY02_04025 ENOG4105DDY UPF0142 protein ycaO GIY02_04030 ENOG4105TMB Formate nitrite transporter GIY02_04035 ENOG4105C6N Formate acetyltransferase GIY02_04040 ENOG4105F1A Pyruvate formate-lyase GIY02_04045 ENOG4108ISG Major Facilitator GIY02_04050 ENOG4107KGK dmso reductase anchor subunit GIY02_04055 ENOG4105QAX Iron-sulfur GIY02_04060 ENOG4107QY8 reductase GIY02_04065 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GIY02_04070 ENOG4105D1H recombination factor protein RarA GIY02_04080 ENOG4105CNU cell division protein FtsK GIY02_04085 ENOG4105EW9 transcriptional regulator AsnC family GIY02_04090 ENOG4105C3M thioredoxin reductase GIY02_04095 ENOG4108JJ9 ABC, transporter GIY02_04100 ENOG4108JJ8 (ABC) transporter GIY02_04110 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GIY02_04115 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GIY02_04125 ENOG4105VEQ Cold shock protein GIY02_04135 ENOG4105DJY efflux transporter, rnd family, mfp subunit GIY02_04140 ENOG4105CPB ATP-dependent endonuclease of the OLD family GIY02_04145 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GIY02_04150 ENOG4105DWU Membrane GIY02_04160 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GIY02_04175 ENOG4105C7K acetolactate synthase GIY02_04180 ENOG4105C5W Aldolase GIY02_04185 ENOG4105CGD Nad-dependent epimerase dehydratase GIY02_04190 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase GIY02_04195 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GIY02_04205 ENOG4105TDT uncharacterized protein yahO GIY02_04210 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GIY02_04215 ENOG41064MM (LipO)protein GIY02_04220 ENOG4105E5Z arginine transporter ATP-binding subunit GIY02_04225 ENOG4106PMH Extracellular solute-binding protein family 3 GIY02_04230 ENOG4105GBT ABC transporter GIY02_04235 ENOG4105DMR ABC, transporter GIY02_04240 ENOG4106TNF Periplasmic binding protein GIY02_04245 ENOG4105ES5 Histidine kinase GIY02_04250 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GIY02_04255 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) GIY02_04260 ENOG4105RBQ inner membrane protein ybjO GIY02_04265 ENOG4105D38 putrescine abc transporter GIY02_04270 ENOG4105F38 ABC transporter, permease GIY02_04275 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GIY02_04280 ENOG4107RUE extracellular solute-binding protein family 1 GIY02_04285 ENOG4108RMJ sensory transduction regulator GIY02_04295 ENOG4108DBC nitroreductase GIY02_04300 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress GIY02_04305 ENOG41090BQ Glutaredoxin GIY02_04310 ENOG4105GWF inner membrane protein YbjM GIY02_04335 ENOG4108RFG Tetr family transcriptional regulator GIY02_04345 ENOG4108HCJ Hydrolase GIY02_04350 ENOG4107QF7 multi-drug GIY02_04360 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GIY02_04365 ENOG4107FB0 transcriptional regulator DeoR family GIY02_04370 ENOG4105DZ1 carboxypeptidase GIY02_04375 ENOG4108TGY Glutathione S-transferase GIY02_04380 ENOG4105D8V Glucose sorbosone dehydrogenase GIY02_04385 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway GIY02_04400 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GIY02_04405 ENOG4105DEF Extracellular solute-binding protein, family 5 GIY02_04410 ENOG4108JQ6 ABC transporter GIY02_04415 ENOG4105D44 asparaginase GIY02_04420 ENOG4105CVM Molybdenum cofactor synthesis domain protein GIY02_04425 ENOG4105D06 uba thif-type nad fad binding protein GIY02_04430 ENOG4105F1A Pyruvate formate-lyase GIY02_04435 ENOG4105C6N Formate acetyltransferase GIY02_04440 ENOG4108HCJ Hydrolase GIY02_04445 ENOG41072TH Protein of unknown function (DUF1479) GIY02_04450 ENOG4105ETE Transcriptional regulator (LacI family GIY02_04455 ENOG4105DPW Major facilitator superfamily MFS_1 GIY02_04465 ENOG4105C5H ABC transporter GIY02_04475 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GIY02_04480 ENOG4108TZY GntR Family Transcriptional Regulator GIY02_04485 ENOG4105CS2 ec 3.2.1.21 GIY02_04490 ENOG4105CPC Aldo Keto reductase GIY02_04495 ENOG4105F4P )-transporter GIY02_04500 ENOG4105KST dependent repressor GIY02_04515 ENOG4108T1M outer membrane protein x GIY02_04525 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GIY02_04530 ENOG4107R0W ABC transporter GIY02_04535 ENOG4105E5Q amino acid AbC transporter GIY02_04540 ENOG4105CDA abc transporter atp-binding protein GIY02_04545 ENOG4105D8X mechanosensitive ion channel GIY02_04550 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) GIY02_04555 ENOG4105EW6 flavin reductase domain protein, FMN-binding GIY02_04560 ENOG4105ZY9 UPF0379 protein ybiM GIY02_04565 ENOG4105KSC Transcriptional regulator, TraR DksA family GIY02_04570 ENOG4105VR4 UPF0379 protein ybiJ GIY02_04575 ENOG4108MTB glycosyl transferase family GIY02_04580 ENOG4105DVT helicase GIY02_04585 ENOG4105C1J atp-dependent rna helicase GIY02_04590 ENOG4107MVR Transcriptional regulator GIY02_04595 ENOG4105D0S secretion protein (HlyD GIY02_04600 ENOG4105CJ1 ABC, transporter GIY02_04605 ENOG4107QWP ABC-2 type transporter GIY02_04610 ENOG4107QWP ABC-2 type transporter GIY02_04615 ENOG4105I9U inner membrane protein ybhQ GIY02_04620 ENOG4105X23 Endonuclease Exonuclease phosphatase GIY02_04625 ENOG4105DZQ phospholipase D Transphosphatidylase GIY02_04630 ENOG4107UXM Membrane GIY02_04635 ENOG4105HFZ Membrane GIY02_04640 ENOG4108ZAF Molybdopterin GIY02_04645 ENOG4105M00 molybdopterin converting factor, subunit 1 GIY02_04655 ENOG4108RIR Molybdenum cofactor biosynthesis protein GIY02_04665 ENOG4105CHW UPF0052 protein GIY02_04670 ENOG4105DIJ Phosphoethanolamine transferase GIY02_04675 ENOG4105XJC Two component transcriptional regulator (Winged helix family GIY02_04680 ENOG4105ECM Sensor protein basS pmrB GIY02_04695 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GIY02_04700 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GIY02_04715 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GIY02_04720 ENOG4108V1U phospholipid-binding protein GIY02_04725 ENOG4105C85 amino acid GIY02_04755 ENOG4105NBR Pectinesterase GIY02_04765 ENOG4105EMN RNA polymerase sigma factor GIY02_04790 ENOG4108XDN Transcriptional regulator GIY02_04795 ENOG4105BZU Histidine kinase GIY02_04800 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component GIY02_04820 ENOG4108K4B hydrolase GIY02_04830 ENOG4105E0C molybdate abc transporter GIY02_04835 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GIY02_04840 ENOG410680R Protein of unknown function (DUF2592) GIY02_04845 ENOG4105F4R Transcriptional regulator mode GIY02_04850 ENOG4105DKW ABC transporter GIY02_04855 ENOG4105CMR udp-glucose 4-epimerase GIY02_04860 ENOG4105F0Z galactose-1-phosphate uridylyltransferase GIY02_04865 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GIY02_04870 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GIY02_04880 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GIY02_04885 ENOG4105JND homeobox protein GIY02_04890 ENOG4105PGM cation diffusion facilitator family transporter GIY02_04895 ENOG4106Z1T Nicotinamide Mononucleotide Transporter GIY02_04900 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GIY02_04940 ENOG4105UFD tol-pal system protein YbgF GIY02_04945 ENOG4105KCK Peptidoglycan-associated lipoprotein GIY02_04955 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA GIY02_04960 ENOG4105M8F Biopolymer transport protein exbD tolR GIY02_04965 ENOG4105E02 MotA TolQ exbB proton channel GIY02_04970 ENOG4107YD3 Thioesterase GIY02_04975 ENOG4105KJB cyd operon protein YbgE GIY02_04985 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GIY02_04990 ENOG4105C4M (Ubiquinol oxidase) subunit I GIY02_05000 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GIY02_05010 ENOG4105C7S Dehydrogenase GIY02_05015 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GIY02_05020 ENOG4105E33 succinate dehydrogenase GIY02_05025 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GIY02_05030 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein GIY02_05035 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit GIY02_05040 ENOG4105BZN citrate synthase GIY02_05045 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) GIY02_05065 ENOG4105E7W lamb ycsf family protein GIY02_05070 ENOG4107R7A Allophanate hydrolase subunit 2 GIY02_05075 ENOG4105P4J Allophanate hydrolase, subunit 1 GIY02_05080 ENOG4107QNR UPF0135 protein GIY02_05090 ENOG4105CVP deoxyribo-dipyrimidine photolyase GIY02_05095 ENOG4105XIQ Protein of unknown function (DUF2517) GIY02_05110 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GIY02_05120 ENOG4105C08 Histidine kinase GIY02_05125 ENOG4105EEX Two component transcriptional regulator (Winged helix family GIY02_05130 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 GIY02_05135 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) GIY02_05140 ENOG4105EV9 Alpha Beta Hydrolase GIY02_05145 ENOG4105NNH LexA regulated protein GIY02_05150 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) GIY02_05155 ENOG41090R7 Ferric uptake GIY02_05160 ENOG4106P55 Transcriptional regulator GIY02_05165 ENOG4107EFR Flavocytochrome c GIY02_05180 ENOG4105GX6 (LipO)protein GIY02_05195 ENOG4105CX6 glutaminyL-tRNA synthetase GIY02_05200 ENOG4105CI1 PTS System GIY02_05210 ENOG4105CE4 GlcNAc 6-P deacetylase GIY02_05215 ENOG4105E2R ROK family GIY02_05225 ENOG4105CAQ asparagine synthetase GIY02_05265 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GIY02_05270 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GIY02_05275 ENOG4105C9A Phoh family GIY02_05285 ENOG4108JU5 Magnesium and cobalt efflux protein GIY02_05290 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GIY02_05295 ENOG4107RP9 extracellular solute-binding protein, family 3 GIY02_05300 ENOG4105EAD ABC transporter GIY02_05305 ENOG4105DRP amino acid AbC transporter GIY02_05310 ENOG4105CDA abc transporter atp-binding protein GIY02_05315 ENOG4105D5K Hemolysin activator protein GIY02_05325 ENOG4107PAI alpha helical protein GIY02_05330 ENOG4105C8T Leucyl-tRNA synthetase GIY02_05340 ENOG4105DJF DNA polymerase III, delta' subunit GIY02_05345 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GIY02_05350 ENOG4108TGR phosphatase GIY02_05355 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GIY02_05365 ENOG4105CJN penicillin-binding protein GIY02_05370 ENOG4105CNI cell division protein FtsW GIY02_05375 ENOG4105K6T rare lipoprotein A GIY02_05380 ENOG4105DZ1 carboxypeptidase GIY02_05390 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GIY02_05395 ENOG41064T2 transcriptional regulator, lysR family GIY02_05405 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) GIY02_05410 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GIY02_05420 ENOG4105VEQ Cold shock protein GIY02_05425 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) GIY02_05430 ENOG4105CEE C4-dicarboxylate transporter GIY02_05435 ENOG4105KTS ribonuclease GIY02_05440 ENOG4105NXH GreA GreB family elongation factor GIY02_05445 ENOG4108U51 Universal stress protein GIY02_05450 ENOG4108JU3 Alkyl hydroperoxide reductase GIY02_05455 ENOG4105D3R alkyl hydroperoxide reductase GIY02_05460 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase GIY02_05470 ENOG4105DQS Transcriptional regulator GIY02_05475 ENOG4105BZV Phosphoadenosine phosphosulfate reductase GIY02_05480 ENOG4105GTN ParB Domain Protein Nuclease GIY02_05485 ENOG4105CHM Aminotransferase GIY02_05495 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GIY02_05510 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GIY02_05520 ENOG4105CNN ABC, transporter GIY02_05525 ENOG4105C2J ABC transporter GIY02_05530 ENOG4105CHR reductase GIY02_05545 ENOG4105VCD cytoplasmic protein GIY02_05550 ENOG4105D22 carbon starvation protein GIY02_05555 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) GIY02_05560 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GIY02_05565 ENOG4105WQI isochorismatase GIY02_05570 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GIY02_05580 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein GIY02_05590 ENOG4105E8G Major facilitator Superfamily GIY02_05595 ENOG4105DQ5 transport system permease protein GIY02_05600 ENOG4105TVJ transport system, permease GIY02_05605 ENOG4105E0A ABC, transporter GIY02_05610 ENOG4105C0W non-ribosomal peptide synthetase GIY02_05615 ENOG41085A6 mbth domain-containing protein GIY02_05620 ENOG4105E93 esterase GIY02_05625 ENOG4107RNH Outer membrane receptor FepA GIY02_05630 ENOG4108IUS Transketolase GIY02_05635 ENOG4108HHA Transketolase GIY02_05640 ENOG4105DKT Transcriptional regulator GIY02_05645 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GIY02_05650 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GIY02_05660 ENOG4105C2J ABC transporter GIY02_05665 ENOG4105CNN ABC, transporter GIY02_05685 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GIY02_05695 ENOG4105C94 Transporter GIY02_05700 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GIY02_05710 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GIY02_05725 ENOG4108T58 Mg2 transport protein CorA GIY02_05735 ENOG4105WQ6 Membrane GIY02_05740 ENOG4105HFT AraC family transcriptional regulator GIY02_05755 ENOG4105MSB protein, conserved in bacteria GIY02_05760 ENOG4108RCM Nitroreductase GIY02_05785 ENOG4105CUY Mechanosensitive ion channel GIY02_05790 ENOG4105C85 amino acid GIY02_05800 ENOG4108NS2 receptor GIY02_05805 ENOG4105CEP NADH dehydrogenase GIY02_05815 ENOG4105C26 Dehydrogenase GIY02_05820 ENOG4105CJP fad dependent oxidoreductase GIY02_05830 ENOG4105CUB amino acid GIY02_05845 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase GIY02_05850 ENOG4105DGU Histone deacetylase GIY02_05860 ENOG4108UAJ Transcriptional regulator GIY02_05870 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) GIY02_05885 ENOG4105CPC Aldo Keto reductase GIY02_05890 ENOG4105E89 ABC transporter GIY02_05895 ENOG4105CH2 amidohydrolase GIY02_05915 ENOG4105EFX secretion protein, HlyD family GIY02_05920 ENOG4105KK7 inner membrane protein YiaW GIY02_05930 ENOG4108NUU Transcriptional regulator GIY02_05935 ENOG4105SZ2 membrAne GIY02_05940 ENOG4107SNB ankyrin repeat protein YahD GIY02_05945 ENOG4105N16 Protein of unknown function (DUF2877) GIY02_05950 ENOG4107R1Q Membrane protein FdrA GIY02_05955 ENOG4107REC cytoplasmic protein GIY02_05960 ENOG4105C5B carbamate kinase GIY02_05965 ENOG4105DZC cytosine deaminase GIY02_05970 ENOG4105CRK lysyL-tRNA synthetase GIY02_05975 ENOG4105DUX Transporter GIY02_05980 ENOG4105CXN decarboxylase GIY02_05985 ENOG4105D5Q Arginine ornithine antiporter GIY02_05995 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GIY02_06005 ENOG4105D1S lipid A biosynthesis GIY02_06070 ENOG4105F04 LysR family Transcriptional regulator GIY02_06080 ENOG4105CSH Transporter GIY02_06090 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) GIY02_06115 ENOG4105WQ3 Rna-binding protein GIY02_06125 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GIY02_06130 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) GIY02_06135 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GIY02_06140 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GIY02_06155 ENOG4105CV6 ABC transporter, permease GIY02_06160 ENOG4108I0Y (ABC) transporter GIY02_06165 ENOG4108UJV acyl-CoA thioesterase i GIY02_06170 ENOG4105E1F short-chain dehydrogenase reductase GIY02_06175 ENOG4107QR8 Thioredoxin GIY02_06180 ENOG4105C4B ABC transporter, permease GIY02_06185 ENOG41083J0 (ABC) transporter GIY02_06190 ENOG4107QX8 SPFH domain, Band 7 family protein GIY02_06195 ENOG4105G5H Membrane GIY02_06200 ENOG4108Z6Z Transcriptional regulator GIY02_06205 ENOG4105C59 p-type ATPase GIY02_06210 ENOG4105MBR gumn family GIY02_06215 ENOG4108Z66 YbaK ebsC protein GIY02_06220 ENOG4105CGH 5'-nucleotidase GIY02_06225 ENOG4105EU0 Major facilitator Superfamily GIY02_06230 ENOG4105CKD glutathione-regulated potassium-efflux system protein GIY02_06235 ENOG4107RE1 Inosine-guanosine kinase GIY02_06250 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GIY02_06255 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GIY02_06265 ENOG4107QMP dna polymerase iii subunits gamma and tau GIY02_06275 ENOG4105WD1 Membrane GIY02_06280 ENOG4108URS primosomal replication protein n'' GIY02_06285 ENOG4106428 Protein of unknown function (DUF2496) GIY02_06290 ENOG4105EGS Mechanosensitive ion channel GIY02_06295 ENOG4108IG5 Transcriptional regulator GIY02_06300 ENOG4105C1P efflux transporter, rnd family, mfp subunit GIY02_06305 ENOG4105BZS acriflavin resistance protein GIY02_06310 ENOG4108UKR Biofilm formation regulator YbaJ GIY02_06320 ENOG4108UW5 maltose o-acetyltransferase GIY02_06325 ENOG4105GSJ Inner membrane protein ylaC GIY02_06340 ENOG4105YK5 50S ribosomal protein L36 GIY02_06350 ENOG41066DG (EAL) domain protein GIY02_06355 ENOG4105KCV RNA signal recognition particle 4.5S RNA GIY02_06360 ENOG4108VW9 Membrane GIY02_06390 ENOG41080UX Methyltransferase GIY02_06395 ENOG4108MNP Glycoprotein polysaccharide metabolism GIY02_06400 ENOG4105C29 acyl-CoA thioesterase GIY02_06405 ENOG4106NZI LysR family Transcriptional regulator GIY02_06410 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GIY02_06415 ENOG4105BZU Histidine kinase GIY02_06420 ENOG4108YZA Nitrogen regulatory protein pii GIY02_06425 ENOG4105BZ1 (ABC) transporter GIY02_06430 ENOG4105BZ1 (ABC) transporter GIY02_06435 ENOG4108XM1 transcriptional regulator AsnC family GIY02_06450 ENOG4108NFA extracellular solute-binding protein GIY02_06460 ENOG4108TGP Thioesterase superfamily protein GIY02_06465 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GIY02_06475 ENOG4105EIN peptidylprolyl cis-trans isomerase GIY02_06480 ENOG4105K70 DNA-binding protein GIY02_06485 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GIY02_06510 ENOG4105M85 Bola protein GIY02_06520 ENOG4105IEY (LipO)protein GIY02_06550 ENOG4105E2S oxidase) subunit II GIY02_06555 ENOG4105BZ9 Cytochrome C oxidase, subunit I GIY02_06560 ENOG4105CCU oxidase (Subunit III) GIY02_06565 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) GIY02_06570 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GIY02_06580 ENOG4107RDB Major Facilitator GIY02_06620 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GIY02_06650 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GIY02_06655 ENOG4105CHR reductase GIY02_06660 ENOG41081XD Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GIY02_06675 ENOG4108VPT UPF0234 protein GIY02_06680 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GIY02_06685 ENOG4107S0N DJ-1 family GIY02_06695 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GIY02_06705 ENOG4105CTB Polyprenyl synthetase GIY02_06710 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GIY02_06715 ENOG4105CPC Aldo Keto reductase GIY02_06720 ENOG4108ZAI phosphatidylglycerophosphatase a GIY02_06725 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GIY02_06735 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GIY02_06740 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GIY02_06750 ENOG4108KIC (LipO)protein GIY02_06755 ENOG4105DRB nucleoside-specific channel-forming protein GIY02_06770 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GIY02_06780 ENOG4105VIE preprotein translocase, subunit YajC GIY02_06785 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GIY02_06800 ENOG4105D3R alkyl hydroperoxide reductase GIY02_06805 ENOG4105EFZ amidohydrolase GIY02_06815 ENOG4105CHJ isochorismatase hydrolase GIY02_06820 ENOG4105EQ1 Transcriptional regulator GIY02_06825 ENOG4107R28 alpha amylase, catalytic region GIY02_06830 ENOG4105C85 amino acid GIY02_06835 ENOG4105CWM branched-chain amino acid transport system II carrier protein GIY02_06840 ENOG4105BZU Histidine kinase GIY02_06845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GIY02_06850 ENOG4107RH8 nuclease SbcCD subunit D GIY02_06855 ENOG4105EYH Exonuclease GIY02_06860 ENOG4105DKQ ROK family GIY02_06875 ENOG4105HBA AroM protein GIY02_06880 ENOG4105SS3 GIY02_06885 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GIY02_06890 ENOG4105G4C Periplasmic ligand-binding sensor protein GIY02_06895 ENOG4108UPT UPF0178 protein GIY02_06900 ENOG4105II7 pyrroline-5-carboxylate reductase GIY02_06905 ENOG4105VIF phosphate starvation-inducible protein GIY02_06925 ENOG4105CPF Cell wall formation (By similarity) GIY02_06930 ENOG4105UNH Membrane GIY02_06935 ENOG4105FR5 inner membrane protein YaiY GIY02_06945 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 GIY02_06955 ENOG4107R6D beta-lactam binding protein AmpH GIY02_06960 ENOG4105D52 delta-aminolevulinic acid dehydratase GIY02_06965 ENOG4108UK5 Transposase GIY02_06980 ENOG4105E2B Taurine dioxygenase GIY02_06985 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GIY02_06990 ENOG4108ETV ABC transporter GIY02_06995 ENOG4106FTQ Taurine ABC transporter, periplasmic GIY02_07000 ENOG4107QK5 Homocysteine s-methyltransferase GIY02_07005 ENOG4108IQI permease GIY02_07015 ENOG4105CT1 (ABC) transporter GIY02_07025 ENOG4105E5Q amino acid AbC transporter GIY02_07030 ENOG4105DRP amino acid AbC transporter GIY02_07035 ENOG410811B TRANSCRIPTIONal GIY02_07040 ENOG4105DJB Major Facilitator Superfamily GIY02_07055 ENOG4106PYX Receptor GIY02_07060 ENOG4108N3D putative enzyme GIY02_07065 ENOG4108NN8 Fimbrial protein GIY02_07085 ENOG4105EHI Phosphonate ABC transporter, periplasmic GIY02_07095 ENOG4105S7S phosphonate abc transporter GIY02_07120 ENOG4105FCK Membrane GIY02_07185 ENOG4108VCD Chaperone GIY02_07210 ENOG4105D5U fad dependent oxidoreductase GIY02_07215 ENOG4105C26 Dehydrogenase GIY02_07220 ENOG4108JPW Aminotransferase GIY02_07225 ENOG4105C85 amino acid GIY02_07230 ENOG4108PVQ transcriptional regulator GIY02_07245 ENOG4107RSM transcriptional regulator GIY02_07255 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GIY02_07270 ENOG4105D3Q Sugar transferase GIY02_07300 ENOG4106WTF Glycosyl transferase, family 2 GIY02_07305 ENOG4105CG5 Glycosyl transferase (Group 1 GIY02_07310 ENOG4107RA4 Glycosyl transferase (Group 1 GIY02_07325 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB GIY02_07335 ENOG4105V1F Fermentation respiration switch protein GIY02_07345 ENOG4105CIN aminoacyl-histidine dipeptidase GIY02_07350 ENOG4108HYG acetyltransferase GIY02_07355 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GIY02_07370 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) GIY02_07375 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GIY02_07380 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GIY02_07385 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GIY02_07400 ENOG4105F7V ErfK ybiS ycfS ynhG family protein GIY02_07405 ENOG4105E7A Glutamine amidotransferase GIY02_07415 ENOG4107QPN acyl-Coa dehydrogenase GIY02_07420 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GIY02_07425 ENOG4108VP3 Lysine exporter protein (LysE YggA) GIY02_07430 ENOG41090KR LysR family transcriptional Regulator GIY02_07440 ENOG4107RZZ dna polymerase iii epsilon subunit GIY02_07450 ENOG4105D1A Methyltransferase GIY02_07455 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GIY02_07460 ENOG4105E9H Lytic Murein transglycosylase GIY02_07465 ENOG4105F2W methyltransferase GIY02_07475 ENOG4105F27 Major Facilitator GIY02_07480 ENOG4105HEI LysR family (Transcriptional regulator GIY02_07485 ENOG4105CV8 reductase GIY02_07520 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GIY02_07525 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GIY02_07530 ENOG4108UMI ABC transporter, permease GIY02_07535 ENOG4105D01 (LipO)protein GIY02_07540 ENOG4108R8X outer membrane lipoprotein GIY02_07545 ENOG4108R96 Methyltransferase, YaeB family GIY02_07555 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion GIY02_07560 ENOG4108YZN class I peptide chain release factor GIY02_07565 ENOG4108VWS Yaeq family GIY02_07570 ENOG4105W1I UPF0253 protein GIY02_07575 ENOG4105M1T rho-binding antiterminator GIY02_07580 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GIY02_07585 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GIY02_07590 ENOG4105CXN decarboxylase GIY02_07600 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GIY02_07605 ENOG4105C0B DNA polymerase III (alpha subunit) GIY02_07610 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GIY02_07615 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GIY02_07645 ENOG4105DZP Membrane-associated zinc metalloprotease GIY02_07650 ENOG4105KNE Phosphatidate cytidylyltransferase GIY02_07660 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GIY02_07685 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GIY02_07690 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GIY02_07695 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GIY02_07700 ENOG4108T8E UPF0325 protein GIY02_07710 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GIY02_07715 ENOG4105C0H protease GIY02_07720 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GIY02_07725 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GIY02_07730 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GIY02_07735 ENOG4105EN6 Membrane GIY02_07745 ENOG4105CMQ Chloride channel GIY02_07755 ENOG4105S6R Iron-hydroxamate transporter permease subunit GIY02_07760 ENOG4105J76 Periplasmic binding protein GIY02_07765 ENOG4105E0A ABC, transporter GIY02_07770 ENOG4105E0K tonB-dependent siderophore receptor GIY02_07775 ENOG4105BZ4 penicillin-binding protein GIY02_07785 ENOG4105CQ7 ATP-dependent helicase GIY02_07790 ENOG4107XID 2'-5' rna ligase GIY02_07795 ENOG4105PW4 Sugar fermentation stimulation protein homolog GIY02_07800 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GIY02_07810 ENOG4105DJ0 Poly(A) Polymerase GIY02_07815 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GIY02_07830 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GIY02_07835 ENOG4107BJW polysaccharide deacetylase GIY02_07840 ENOG4108YTN IIa component GIY02_07845 ENOG4105E3A (ABC) transporter GIY02_07850 ENOG4105DA5 (ABC) transporter GIY02_07855 ENOG41077A9 carbonic anhydrase GIY02_07860 ENOG4108UGV hypoxanthine phosphoribosyltransferase GIY02_07865 ENOG4105DZG Dehydrogenase GIY02_07870 ENOG4105E3B Multicopper oxidase GIY02_07875 ENOG4108ZRK uncharacterized protein yacC GIY02_07885 ENOG4108V1T peptidylprolyl cis-trans isomerase GIY02_07890 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GIY02_07895 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GIY02_07905 ENOG4107QIJ Aconitate hydratase 2 GIY02_07910 ENOG4108NST exported protein GIY02_07925 ENOG4107QN2 dihydrolipoyl dehydrogenase GIY02_07930 ENOG4107QSN dihydrolipoamide acetyltransferase GIY02_07935 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GIY02_07940 ENOG41073TP transcriptional regulator GIY02_07945 ENOG4105C85 amino acid GIY02_07950 ENOG4105CT4 transporter GIY02_07955 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GIY02_07960 ENOG4106A72 regulatory protein AmpE GIY02_07970 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GIY02_07975 ENOG4108ZUW Major pilin subunit GIY02_07980 ENOG4107QHF type ii secretion system protein e GIY02_07985 ENOG4105D7Q type ii secretion system GIY02_07995 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GIY02_08010 ENOG4105M6F mutator MutT protein GIY02_08015 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GIY02_08020 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) GIY02_08025 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GIY02_08030 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GIY02_08035 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GIY02_08040 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) GIY02_08045 ENOG4105CPF Cell wall formation (By similarity) GIY02_08060 ENOG4105CNI cell division protein FtsW GIY02_08070 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GIY02_08075 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) GIY02_08080 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GIY02_08085 ENOG4105CJN penicillin-binding protein GIY02_08090 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GIY02_08105 ENOG4107B7Y DNA-binding transcriptional regulator FruR GIY02_08110 ENOG4108ZP8 Acetolactate synthase small subunit GIY02_08125 ENOG41064T2 transcriptional regulator, lysR family GIY02_08135 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GIY02_08145 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GIY02_08165 ENOG4105EMV Major Facilitator GIY02_08170 ENOG4105FF2 Type I DHQase GIY02_08175 ENOG4105DND Transcriptional regulator GIY02_08180 ENOG4105DJB Major Facilitator Superfamily GIY02_08185 ENOG4105S8Q sugar efflux transporter GIY02_08200 ENOG4105DP9 ABC transporter GIY02_08205 ENOG4106SMU thiamine transporter membrane protein GIY02_08215 ENOG4108KF1 Membrane GIY02_08230 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) GIY02_08235 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GIY02_08240 ENOG4105CQ2 DNA polymerase GIY02_08245 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) GIY02_08250 ENOG4105D3G Pseudouridine synthase GIY02_08260 ENOG4105D2K citrate carrier protein GIY02_08265 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GIY02_08270 ENOG4106YYS transcriptional regulatory protein GIY02_08275 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) GIY02_08280 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) GIY02_08290 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GIY02_08310 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GIY02_08330 ENOG4105M5B (LipO)protein GIY02_08335 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GIY02_08340 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GIY02_08350 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase GIY02_08355 ENOG4105CHY citrate lyase, alpha GIY02_08360 ENOG4105CI0 Citrate lyase GIY02_08375 ENOG4105D2K citrate carrier protein GIY02_08390 ENOG4105D9Q decarboxylase (Beta subunit) GIY02_08395 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GIY02_08400 ENOG4106YYS transcriptional regulatory protein GIY02_08405 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GIY02_08410 ENOG4105EXG Transcriptional regulator GIY02_08415 ENOG4107QM5 aconitate hydratase GIY02_08425 ENOG4107QPK )-transporter GIY02_08430 ENOG4105C7F AcnD-accessory protein PrpF GIY02_08440 ENOG4105F04 LysR family Transcriptional regulator GIY02_08445 ENOG4105DU0 nucleoside hydrolase GIY02_08455 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase GIY02_08460 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GIY02_08470 ENOG4105DTN riboflavin biosynthesis protein ribF GIY02_08485 ENOG41063Z6 transcriptional regulator, lysR family GIY02_08490 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GIY02_08505 ENOG4106PH7 chaperone GIY02_08520 ENOG4105MHR Fimbrial protein GIY02_08525 ENOG4105CW0 outer membrane usher protein GIY02_08530 ENOG4108AF8 Chaperone GIY02_08535 ENOG4105HMV Fimbrial protein GIY02_08540 ENOG4108PNB DNA-binding transcriptional regulator GIY02_08575 ENOG4108PTX LysR family Transcriptional regulator GIY02_08580 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GIY02_08585 ENOG4105CFG Acts as a chaperone (By similarity) GIY02_08590 ENOG4106HK8 GPR1 FUN34 yaaH family protein GIY02_08595 ENOG4105CSH Transporter GIY02_08600 ENOG4108RIR Molybdenum cofactor biosynthesis protein GIY02_08610 ENOG4105BZG amino acid carrier protein GIY02_08620 ENOG4105D98 threonine synthase GIY02_08625 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GIY02_08630 ENOG4105CFH Aspartokinase GIY02_08640 ENOG4106FVC RNA methyltransferase GIY02_08645 ENOG410759A GIY02_08650 ENOG41065U4 response regulator GIY02_08655 ENOG4105CT7 inner membrane cred family protein GIY02_08660 ENOG4105EB3 Histidine kinase GIY02_08665 ENOG4105E3W Two component transcriptional regulator (Winged helix family GIY02_08670 ENOG4108RH0 Crea protein GIY02_08675 ENOG4105UEI Transcriptional Regulator AraC Family GIY02_08680 ENOG4105CVJ phosphoglycerate mutase GIY02_08690 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) GIY02_08695 ENOG4107SC1 transglycosylase GIY02_08700 ENOG4105C5H ABC transporter GIY02_08705 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase GIY02_08710 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GIY02_08715 ENOG4105EAC phosphoserine phosphatase GIY02_08720 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) GIY02_08725 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) GIY02_08740 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GIY02_08750 ENOG4105EYA deoxyribonuclease GIY02_08755 ENOG4108NRW Phospholipase, patatin family GIY02_08765 ENOG4105K3G Periplasmic Protein GIY02_08775 ENOG4105PAD Hydrolase GIY02_08780 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GIY02_08785 ENOG4108WPU DNA polymerase III subunit psi GIY02_08810 ENOG4105YBH Protein of unknown function (DUF1435) GIY02_08815 ENOG4106TD9 Diguanylate cyclase GIY02_08820 ENOG4108819 ferric iron reductase GIY02_08825 ENOG4105CK1 PTS System GIY02_08830 ENOG4108UIN ybak prolyl-trna synthetase associated region GIY02_08835 ENOG4108T94 DNA-binding transcriptional activator BglJ GIY02_08840 ENOG4108N8T regulatoR GIY02_08850 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase GIY02_08855 ENOG4105DWK Membrane GIY02_08865 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) GIY02_08870 ENOG4106CVF DNA replication protein GIY02_08880 ENOG4107RES phosphoglycerol transferase I GIY02_08890 ENOG4105XYF acetyltransferase GIY02_08895 ENOG4105CHC glucokinase (EC 2.7.1.2) GIY02_08900 ENOG4108RTU Aldolase GIY02_08905 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 GIY02_08930 ENOG4105DG4 malate L-lactate dehydrogenase GIY02_08935 ENOG4107QTZ amino acid GIY02_08940 ENOG4105CZJ Aldehyde dehydrogenase GIY02_08945 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GIY02_08960 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GIY02_08970 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein GIY02_08980 ENOG4105ERH Fumarylacetoacetate hydrolase GIY02_08990 ENOG4105C26 Dehydrogenase GIY02_08995 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase GIY02_09010 ENOG4105CNV Aldolase GIY02_09025 ENOG4105EFA 4-hydroxyphenylacetate GIY02_09030 ENOG4107UWN reductase GIY02_09040 ENOG4105CKT filamentous hemagglutinin GIY02_09045 ENOG4105CKT filamentous hemagglutinin GIY02_09075 ENOG4105D5K Hemolysin activator protein GIY02_09085 ENOG4105VCD cytoplasmic protein GIY02_09090 ENOG4105CKI cobalamin synthesis protein GIY02_09095 ENOG4105C26 Dehydrogenase GIY02_09100 ENOG4106BRA Membrane GIY02_09105 ENOG41083G8 Multidrug resistance protein MdtM GIY02_09115 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase GIY02_09120 ENOG4105CIZ coA-substrate-specific enzyme activase GIY02_09135 ENOG4108P2H Inner membrane protein YjiG GIY02_09140 ENOG41074DU domain protein GIY02_09155 ENOG4105EFX secretion protein, HlyD family GIY02_09165 ENOG4106DIZ Domain of unknown function (DUF1127) GIY02_09170 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GIY02_09180 ENOG4105CUB amino acid GIY02_09200 ENOG4108EQA pts system GIY02_09205 ENOG4105ETZ PTS System GIY02_09210 ENOG4105F3R pts system mannose fructose sorbose family iid GIY02_09240 ENOG4105KNY Microcompartments protein GIY02_09245 ENOG4105KNY Microcompartments protein GIY02_09250 ENOG4105KNY Microcompartments protein GIY02_09255 ENOG4108EKI Dehydrogenase GIY02_09270 ENOG4105C6N Formate acetyltransferase GIY02_09275 ENOG4105F1A Pyruvate formate-lyase GIY02_09280 ENOG4105KNY Microcompartments protein GIY02_09285 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) GIY02_09310 ENOG4105BZU Histidine kinase GIY02_09315 ENOG4105D0S secretion protein (HlyD GIY02_09320 ENOG4105CJ1 ABC, transporter GIY02_09325 ENOG4105CMI transporter GIY02_09360 ENOG4105EZE Cupin 4 family protein GIY02_09365 ENOG4105GR3 Histidine kinase GIY02_09370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GIY02_09375 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GIY02_09380 ENOG410624V efflux system protein GIY02_09385 ENOG4105EP1 Efflux transporter rnd family, mfp subunit GIY02_09390 ENOG4108IJF Heavy metal efflux pump, CzcA GIY02_09545 ENOG41077A9 carbonic anhydrase GIY02_09550 ENOG4105CHH sulfate transporter GIY02_09555 ENOG4105DQ4 alcohol dehydrogenase GIY02_09565 ENOG4105DRS transport system, permease GIY02_09570 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GIY02_09575 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GIY02_09585 ENOG4107QNK )-transporter GIY02_09590 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) GIY02_09595 ENOG4105F0H myo-inositol catabolism protein GIY02_09605 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GIY02_09615 ENOG4105D7K pfkb domain protein GIY02_09620 ENOG4105CHC glucokinase (EC 2.7.1.2) GIY02_09625 ENOG4105DH8 myo-inositol catabolism GIY02_09630 ENOG4105C26 Dehydrogenase GIY02_09640 ENOG4105D7A ATP-binding protein GIY02_09645 ENOG4108K5H permease YjgP YjgQ family protein GIY02_09650 ENOG4108M8S permease YjgP YjgQ family protein GIY02_09660 ENOG4105MYG DNA polymerase iii, chi subunit GIY02_09665 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GIY02_09670 ENOG4108MJ3 acetyltransferase GIY02_09675 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase GIY02_09680 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) GIY02_09685 ENOG4105DBV ornithine carbamoyltransferase GIY02_09690 ENOG4105XEP YhcH YjgK YiaL family protein GIY02_09700 ENOG4105CXT aspartate transcarbamylase GIY02_09705 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) GIY02_09710 ENOG4105KME endoribonuclease L-psp GIY02_09715 ENOG4105E2D ec 3.2.1.52 GIY02_09725 ENOG4105D4X repressor GIY02_09730 ENOG4105C5Y PTS System GIY02_09735 ENOG4105CG3 alpha amylase, catalytic region GIY02_09740 ENOG4105CK1 PTS System GIY02_09745 ENOG4105F8D glycoside hydrolase family 4 GIY02_09760 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GIY02_09765 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GIY02_09770 ENOG4105EMD TRANSCRIPTIONal GIY02_09775 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GIY02_09790 ENOG41069H0 dihydroorotase EC 3.5.2.3 GIY02_09820 ENOG4108XVM Cytochrome b(562) GIY02_09825 ENOG4105CMS peptidase U62, modulator of DNA gyrase GIY02_09830 ENOG4105N42 UPF0307 protein GIY02_09840 ENOG4105DFU Cell wall formation (By similarity) GIY02_09850 ENOG41062B0 ABC transporter, permease GIY02_09855 ENOG4107R9N ABC transporter GIY02_09860 ENOG4105C2J ABC transporter GIY02_09865 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator GIY02_09870 ENOG4105F0N pyrophosphate phospho-hydrolase GIY02_09875 ENOG4108ZHD aig2 family GIY02_09880 ENOG4105MA0 exported protein GIY02_09885 ENOG4105CFU surface antigen GIY02_09895 ENOG4105C37 (CBS) domain GIY02_09900 ENOG41061GZ Protein of unknown function (DUF1107) GIY02_09905 ENOG4108UUE Transcriptional regulator GIY02_09910 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase GIY02_09915 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GIY02_09920 ENOG4105KVH Transcriptional regulator GIY02_09925 ENOG4105ECR NmrA family GIY02_09935 ENOG4105DXC membrane GIY02_09940 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GIY02_09950 ENOG4108V1T peptidylprolyl cis-trans isomerase GIY02_09955 ENOG4105FHY Opacity-associated protein A GIY02_09965 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GIY02_09970 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GIY02_09975 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) GIY02_09985 ENOG4105KIT UPF0379 protein yjfY GIY02_10010 ENOG4106ETB IIa component GIY02_10015 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport GIY02_10020 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GIY02_10035 ENOG4108MXZ Esterase GIY02_10040 ENOG4105WSB biofilm stress and motility protein A GIY02_10045 ENOG4105S17 UPF0379 protein yjfN GIY02_10050 ENOG4105CSU acyl-Coa dehydrogenase GIY02_10055 ENOG4105CSH Transporter GIY02_10060 ENOG4105C2N RNA methyltransferase TrmH family group 3 GIY02_10065 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GIY02_10075 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GIY02_10090 ENOG4105EPW hflc protein GIY02_10095 ENOG4107QJR hflk protein GIY02_10100 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GIY02_10105 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GIY02_10115 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GIY02_10120 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GIY02_10125 ENOG4105K8N protein family UPF0079, ATPase GIY02_10130 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GIY02_10135 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GIY02_10155 ENOG4106TNF Periplasmic binding protein GIY02_10160 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GIY02_10170 ENOG4105DJ4 phosphatidylserine decarboxylase GIY02_10175 ENOG4105EGS Mechanosensitive ion channel GIY02_10180 ENOG4107SC7 Inner membrane transporter yjeM GIY02_10195 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GIY02_10200 ENOG4105E33 succinate dehydrogenase GIY02_10220 ENOG4105KPY Small multidrug resistance protein GIY02_10225 ENOG4106BSU Entericidin B GIY02_10240 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GIY02_10260 ENOG4105CW0 outer membrane usher protein GIY02_10270 ENOG4108JJA ABC, transporter GIY02_10275 ENOG4105MTB Uncharacterized protein YjeJ GIY02_10280 ENOG4108ZVF (LipO)protein GIY02_10285 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GIY02_10295 ENOG4105DVH amino acid GIY02_10300 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 GIY02_10305 ENOG4108IJ0 Aspartate ammonia-lyase GIY02_10310 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GIY02_10320 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GIY02_10325 ENOG4108SIC Transcriptional regulator GIY02_10370 ENOG4108TUY outer membrane protein PgaA GIY02_10375 ENOG4107BJW polysaccharide deacetylase GIY02_10380 ENOG4105CND Glycosyl transferase, family 2 GIY02_10395 ENOG4108ZCF integral membrane protein GIY02_10425 ENOG4105CT4 transporter GIY02_10430 ENOG4105F8D glycoside hydrolase family 4 GIY02_10435 ENOG4108K2B transcriptional regulator GIY02_10440 ENOG4105CSH Transporter GIY02_10450 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GIY02_10455 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase GIY02_10460 ENOG4107RJJ Transcriptional regulator GIY02_10465 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG GIY02_10470 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH GIY02_10475 ENOG4105EKV Phosphonate metabolism protein GIY02_10480 ENOG4105FT8 Phosphonate metabolism GIY02_10485 ENOG4105ENV phosphonate C-P lyase system protein PhnK GIY02_10490 ENOG4105HRV phosphonate c-p lyase system protein phnl GIY02_10495 ENOG4105FD8 phosphonate metabolism protein PhnM GIY02_10500 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) GIY02_10505 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein GIY02_10510 ENOG4106ZVZ Escherichia coli IMT2125 genomic chromosome, IMT2125 GIY02_10515 ENOG4105BZU Histidine kinase GIY02_10520 ENOG4105C2J ABC transporter GIY02_10525 ENOG4105CNN ABC, transporter GIY02_10530 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GIY02_10550 ENOG41082ND Uncharacterized protein yjcO GIY02_10555 ENOG4105CK2 sodium dicarboxylate symporter GIY02_10560 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GIY02_10565 ENOG41062QD Membrane GIY02_10575 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin GIY02_10580 ENOG4108SQA Fimbrial GIY02_10585 ENOG4105CW0 outer membrane usher protein GIY02_10590 ENOG4108AF8 Chaperone GIY02_10595 ENOG4105MX3 Fimbrial GIY02_10600 ENOG41067MG lrgb family GIY02_10605 ENOG4105VAW lrga family GIY02_10610 ENOG4105CMU LysR family (Transcriptional regulator GIY02_10615 ENOG4105EEQ Na H antiporter GIY02_10620 ENOG4105C7N Xanthine uracil vitamin C permease GIY02_10625 ENOG4108K3A Glutathione S-transferase GIY02_10630 ENOG4108Z4X TRANSCRIPTIONal GIY02_10635 ENOG4108W3Q Transcriptional regulator GIY02_10645 ENOG4105PMV Membrane GIY02_10655 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GIY02_10680 ENOG4108UUM single-stranded DNA-binding protein GIY02_10685 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GIY02_10700 ENOG4105MSB protein, conserved in bacteria GIY02_10705 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GIY02_10715 ENOG4105CGF Aromatic amino acid aminotransferase GIY02_10720 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GIY02_10725 ENOG4105CDU Replicative dna helicase GIY02_10730 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GIY02_10735 ENOG4105P4Z Phage shock protein G GIY02_10740 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GIY02_10750 ENOG4105MYN Zinc uptake regulation protein GIY02_10755 ENOG4105VDW Csbd family GIY02_10760 ENOG4107R73 Mate efflux family protein GIY02_10770 ENOG41080IJ Diacylglycerol kinase GIY02_10775 ENOG4105E55 glycerol-3-phosphate acyltransferase GIY02_10780 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) GIY02_10785 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) GIY02_10790 ENOG4107W52 maltose operon periplasmic protein GIY02_10795 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GIY02_10805 ENOG4107FKK extracellular solute-binding protein family 1 GIY02_10810 ENOG4105D56 permease protein GIY02_10815 ENOG4105EG2 ABC transporter, permease GIY02_10820 ENOG4108VY7 phosphate-starvation-inducible protein PsiE GIY02_10825 ENOG4105CEM UPF0597 protein GIY02_10840 ENOG4105KME endoribonuclease L-psp GIY02_10845 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GIY02_10850 ENOG4107QP8 phosphohexose isomerase GIY02_10855 ENOG4105CFH Aspartokinase GIY02_10860 ENOG4105C09 Bile acid GIY02_10875 ENOG4108ZR5 Conserved Protein GIY02_10880 ENOG4105FE9 pseudouridine synthase GIY02_10885 ENOG4105N0E Protein of unknown function (DUF2543) GIY02_10895 ENOG4105EAM Na Pi-cotransporter GIY02_10900 ENOG4105C3R Methionine synthase GIY02_10905 ENOG41069M3 Transcriptional regulator GIY02_10910 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) GIY02_10915 ENOG4108I9X Isocitrate lyase GIY02_10920 ENOG4107QP3 malate synthase g GIY02_10925 ENOG4105CVG Homoserine O-transsuccinylase GIY02_10930 ENOG41062WK cellular response to acidity GIY02_10960 ENOG4105C12 Phosphoribosylglycinamide synthetase GIY02_10970 ENOG4105BZU Histidine kinase GIY02_10980 ENOG4108T8B Protein of unknown function (DUF1481) GIY02_10985 ENOG4105K70 DNA-binding protein GIY02_10990 ENOG4105R2J Conserved Protein GIY02_11010 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) GIY02_11020 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GIY02_11025 ENOG4105D06 uba thif-type nad fad binding protein GIY02_11030 ENOG4105WHD thiamine biosynthesis protein ThiS GIY02_11035 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GIY02_11040 ENOG4105D41 biosynthesis protein thiH GIY02_11045 ENOG4106TD9 Diguanylate cyclase GIY02_11055 ENOG4105VCP PTS System GIY02_11060 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GIY02_11065 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GIY02_11080 ENOG4108VZM 50s ribosomal protein L10 GIY02_11095 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GIY02_11100 ENOG4105PM1 preprotein translocase subunit SecE GIY02_11105 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GIY02_11135 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GIY02_11175 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) GIY02_11185 ENOG4108Y73 Membrane GIY02_11190 ENOG4105EJ2 Transcriptional regulator GIY02_11195 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) GIY02_11200 ENOG4105C5Q Transcriptional regulator GIY02_11205 ENOG4105CH7 arginosuccinase GIY02_11215 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GIY02_11220 ENOG4105CWC Acetylornithine deacetylase GIY02_11230 ENOG4108MEK Metal-binding protein YodA GIY02_11235 ENOG4106R3P AraC family transcriptional regulator GIY02_11245 ENOG4105DCT glycerol dehydrogenase GIY02_11250 ENOG4108Q5Y Membrane GIY02_11255 ENOG4105SYT Methylenetetrahydrofolate reductase GIY02_11260 ENOG4105CFH Aspartokinase GIY02_11265 ENOG4105C28 cystathionine GIY02_11275 ENOG4105VFB Binds the 23S rRNA (By similarity) GIY02_11280 ENOG4105C25 Primosomal protein n' GIY02_11285 ENOG4105ETE Transcriptional regulator (LacI family GIY02_11290 ENOG41063M6 Cell Division Protein GIY02_11300 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GIY02_11305 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GIY02_11320 ENOG41076HS cation diffusion facilitator family transporter GIY02_11325 ENOG4105FMW periplasmic GIY02_11330 ENOG4105E3W Two component transcriptional regulator (Winged helix family GIY02_11335 ENOG4105E0F Histidine kinase GIY02_11340 ENOG4108RPX mosc domain containing protein GIY02_11345 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GIY02_11355 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) GIY02_11380 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) GIY02_11385 ENOG4105C0A alcohol dehydrogenase GIY02_11400 ENOG4108R66 Conserved Protein GIY02_11405 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GIY02_11410 ENOG4108RVA ribokinase GIY02_11420 ENOG4108UMN azlc family GIY02_11435 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GIY02_11445 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GIY02_11450 ENOG4108MG3 formate dehydrogenase GIY02_11465 ENOG4105SUU thioesterase domain GIY02_11475 ENOG4107S2Z UPF0761 membrane protein GIY02_11480 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 GIY02_11490 ENOG4105C5F glutamine synthetase GIY02_11495 ENOG4105CUX Signal transduction histidine kinase GIY02_11500 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GIY02_11505 ENOG4105D4P Coproporphyrinogen iii oxidase GIY02_11510 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) GIY02_11525 ENOG4105C2M dna polymerase I GIY02_11540 ENOG4105E27 serine threonine protein kinase GIY02_11545 ENOG4105PC1 Conserved Protein GIY02_11550 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GIY02_11555 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b GIY02_11580 ENOG4108RR8 protoporphyrinogen oxidase GIY02_11585 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GIY02_11595 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) GIY02_11605 ENOG4105CHU acetyl-coa acetyltransferase GIY02_11610 ENOG4107QK7 reductase GIY02_11620 ENOG4105MDZ Transcriptional activator rfaH GIY02_11630 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GIY02_11640 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GIY02_11645 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GIY02_11650 ENOG4105JC1 sterol-binding domain protein GIY02_11655 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GIY02_11660 ENOG4105CGY Dna recombination protein GIY02_11665 ENOG4107SXA Phosphorylase GIY02_11670 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) GIY02_11680 ENOG4105DZ2 Transcriptional regulator GIY02_11685 ENOG4105EMK carboxylate amino acid amine transporter GIY02_11690 ENOG4105DQF Hydrolase GIY02_11695 ENOG4108EUD Lysophospholipase GIY02_11700 ENOG410829K Lysine exporter protein (Lyse ygga) GIY02_11710 ENOG4105CCF Lysine exporter protein (Lyse ygga) GIY02_11715 ENOG4105C9U ATP-dependent DNA helicase RecQ GIY02_11720 ENOG4105HDD phospholipase GIY02_11725 ENOG4108VUY thioesterase Superfamily protein GIY02_11730 ENOG4105FR1 rard protein GIY02_11740 ENOG4105C4R Atp-dependent dna helicase GIY02_11745 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant GIY02_11750 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GIY02_11755 ENOG4105CT0 Protein of unknown function, DUF484 GIY02_11765 ENOG4105S7Z (LipO)protein GIY02_11770 ENOG4105XQ6 frataxin-like protein GIY02_11775 ENOG4107T0K Adenylate cyclase GIY02_11785 ENOG41076E6 Uroporphyrinogen-III Synthase GIY02_11790 ENOG4105ECF c-methyltransferase GIY02_11795 ENOG410601J HemY protein GIY02_11825 ENOG4105C85 amino acid GIY02_11830 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family GIY02_11835 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) GIY02_11840 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) GIY02_11845 ENOG4105EGZ biosynthesis protein GIY02_11850 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GIY02_11855 ENOG4108WJ1 acetyltransferase GIY02_11860 ENOG4108IJ1 Dehydrogenase GIY02_11865 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GIY02_11870 ENOG4105SFE lipopolysaccharide biosynthesis protein GIY02_11875 ENOG4105ESV Glycosyl transferase, family 4 GIY02_11885 ENOG4105K63 Thioredoxin GIY02_11890 ENOG4105C1J atp-dependent rna helicase GIY02_11900 ENOG4105G2Y Transcriptional regulator GIY02_11910 ENOG4108UQV Membrane GIY02_11915 ENOG4105C4R Atp-dependent dna helicase GIY02_11920 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GIY02_11935 ENOG4105EMY transcriptional regulator GIY02_11940 ENOG4105C7B Threonine dehydratase GIY02_11950 ENOG4105CM2 brancheD-chain amino acid aminotransferase GIY02_11955 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit GIY02_11970 ENOG4105C0P Mg chelatase subunit ChlI GIY02_11975 ENOG4108WFC UPF0438 protein yifE GIY02_12020 ENOG4107EJG GntR family transcriptional regulator GIY02_12025 ENOG4105C0R drug resistance transporter emrb qaca subfamily GIY02_12030 ENOG4105ETE Transcriptional regulator (LacI family GIY02_12035 ENOG4108RVA ribokinase GIY02_12040 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GIY02_12045 ENOG4105CNN ABC, transporter GIY02_12050 ENOG4105C2J ABC transporter GIY02_12070 ENOG4105EV2 VWA domain protein interacting with AAA ATPase GIY02_12080 ENOG4108VVK transcriptional Regulator, AsnC GIY02_12085 ENOG4105QTB Flavodoxin GIY02_12090 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GIY02_12100 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation GIY02_12110 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GIY02_12125 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GIY02_12135 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GIY02_12140 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GIY02_12150 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GIY02_12160 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) GIY02_12165 ENOG4105C8U phosphate abc transporter GIY02_12170 ENOG4105E2Z phosphate ABC transporter (Permease GIY02_12190 ENOG4108P68 Outer membrane porin GIY02_12195 ENOG4105DYC esterase GIY02_12205 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 GIY02_12210 ENOG4105C7N Xanthine uracil vitamin C permease GIY02_12215 ENOG4108YYH Nadph-dependent fmn reductase GIY02_12220 ENOG4105E8Q phosphopantetheinyl transferase GIY02_12230 ENOG4105G2Y Transcriptional regulator GIY02_12245 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GIY02_12250 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GIY02_12260 ENOG4105VG0 50S ribosomal protein l34 GIY02_12270 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GIY02_12275 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GIY02_12280 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GIY02_12285 ENOG410667J hydrolase GIY02_12300 ENOG4105EMF GntR family transcriptional regulator GIY02_12305 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 GIY02_12310 ENOG4108RTU Aldolase GIY02_12315 ENOG4105CXK mandelate racemase muconate lactonizing GIY02_12320 ENOG4105DJB Major Facilitator Superfamily GIY02_12325 ENOG4105D99 atp gtp-binding protein GIY02_12330 ENOG4105R2A (LipO)protein GIY02_12345 ENOG4105D0C transport protein GIY02_12350 ENOG4105FDP GntR family transcriptional regulator GIY02_12355 ENOG4105CI1 PTS System GIY02_12360 ENOG4105F8D glycoside hydrolase family 4 GIY02_12365 ENOG4105VG5 Membrane GIY02_12370 ENOG4105JP4 Inner membrane protein yidG GIY02_12390 ENOG4105W8I Transcriptional regulator GIY02_12395 ENOG4105E5M Multidrug resistance protein D GIY02_12420 ENOG4105C7K acetolactate synthase GIY02_12425 ENOG4105M71 acetolactate synthase 1 regulatory subunit GIY02_12430 ENOG4108KX4 response regulator GIY02_12435 ENOG4105BZU Histidine kinase GIY02_12440 ENOG4105CXY transporter GIY02_12445 ENOG4105CXY transporter GIY02_12450 ENOG4108SAJ Protein of unknown function (DUF1198) GIY02_12470 ENOG4108KAZ Involved in phosphonate degradation (By similarity) GIY02_12475 ENOG4107STF Involved in phosphonate degradation (By similarity) GIY02_12480 ENOG4106S9K Transcriptional regulator GIY02_12495 ENOG4108MP3 ABC transporter, permease GIY02_12510 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GIY02_12515 ENOG4105CK1 PTS System GIY02_12525 ENOG4105DDV Transcriptional regulator (LacI family GIY02_12540 ENOG4108UZ3 Transporter GIY02_12545 ENOG4108RS6 transposase GIY02_12550 ENOG4105D7V transposase GIY02_12585 ENOG410630P Transcriptional regulator GIY02_12595 ENOG4105C1P efflux transporter, rnd family, mfp subunit GIY02_12600 ENOG4105BZS acriflavin resistance protein GIY02_12605 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GIY02_12610 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GIY02_12615 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) GIY02_12620 ENOG4105D01 (LipO)protein GIY02_12630 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein GIY02_12640 ENOG4105DQ4 alcohol dehydrogenase GIY02_12645 ENOG41067V3 Antibiotic biosynthesis monooxygenase GIY02_12685 ENOG4105CT4 transporter GIY02_12690 ENOG4105CJQ hydrolase, family 31 GIY02_12695 ENOG4105ETD TRANSCRIPTIONal GIY02_12700 ENOG4105DM4 PTS System GIY02_12705 ENOG4108YRF PTS System GIY02_12710 ENOG4105DM4 PTS System GIY02_12715 ENOG4105D2N Aldolase GIY02_12720 ENOG4105D2N Aldolase GIY02_12725 ENOG4105DKQ ROK family GIY02_12740 ENOG4105F8D glycoside hydrolase family 4 GIY02_12745 ENOG4105CI1 PTS System GIY02_12750 ENOG4105JV1 AsmA family GIY02_12755 ENOG4105C2W permease GIY02_12760 ENOG4105D6U Sodium Glutamate Symporter GIY02_12770 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GIY02_12775 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) GIY02_12780 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein GIY02_12795 ENOG4105CP7 Triose-phosphate isomerase GIY02_12800 ENOG4105EBK exported protein GIY02_12805 ENOG4108VTS Membrane GIY02_12810 ENOG4105DP0 ferredoxin-NADP reductase GIY02_12815 ENOG4105CBT Fructose-1,6-bisphosphatase GIY02_12820 ENOG4105CB5 ATP-dependent DNA helicase recG GIY02_12825 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GIY02_12830 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GIY02_12835 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GIY02_12840 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GIY02_12850 ENOG4105EN6 Membrane GIY02_12855 ENOG4105DSJ YicC domain protein GIY02_12880 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GIY02_12885 ENOG4105W5Q DNA repair protein (RadC GIY02_12890 ENOG4105KDC 50s ribosomal protein l28 GIY02_12905 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GIY02_12910 ENOG4106WTF Glycosyl transferase, family 2 GIY02_12915 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase GIY02_12920 ENOG4105K64 Glycosyl transferase, family 2 GIY02_12935 ENOG4105DKP glycosyl transferase, family 9 GIY02_12960 ENOG4105D16 lipopolysaccharide heptosyltransferase i GIY02_12965 ENOG4105XA0 heptosyltransferase ii GIY02_12975 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GIY02_12980 ENOG4105CPQ Dehydrogenase GIY02_12990 ENOG4106WTF Glycosyl transferase, family 2 GIY02_12995 ENOG4105PXI polysaccharide deacetylase GIY02_13000 ENOG41063SB peptidase GIY02_13010 ENOG4107YZP Rhodanese domain protein GIY02_13015 ENOG4105VW4 glutaredoxin 3 GIY02_13025 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GIY02_13030 ENOG4105D7W serine acetyltransferase GIY02_13035 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GIY02_13040 ENOG4105DMF Dehydrogenase GIY02_13045 ENOG41073TP transcriptional regulator GIY02_13050 ENOG4105DAA L-lactate GIY02_13055 ENOG4108YYI Protein of unknown function (DUF2810) GIY02_13060 ENOG41060ND LF82 chromosome, complete sequence GIY02_13065 ENOG4105E61 Mannitol repressor protein GIY02_13075 ENOG4105CTS PTS system mannitol-specific GIY02_13080 ENOG4105FP6 Protein of unknown function (DUF3302) GIY02_13085 ENOG4105EFX secretion protein, HlyD family GIY02_13090 ENOG4108U78 Glutathione S-transferase GIY02_13095 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) GIY02_13100 ENOG4105EM7 Selenocysteine-specific translation elongation factor GIY02_13105 ENOG4105C0A alcohol dehydrogenase GIY02_13110 ENOG4108RC0 Electron transport protein GIY02_13120 ENOG4107T9C Alpha amylase catalytic region GIY02_13125 ENOG4108UR8 BAX protein GIY02_13130 ENOG4105T16 Transcriptional regulator (AraC family) GIY02_13135 ENOG4107RNG ABC transporter GIY02_13140 ENOG4105C2J ABC transporter GIY02_13145 ENOG4105DFW ABC transporter GIY02_13150 ENOG4105C93 Xylose Isomerase GIY02_13155 ENOG4105CMG Carbohydrate kinase GIY02_13160 ENOG410688U Inner membrane protein yiaB GIY02_13165 ENOG4105MEV Acyl-transferase GIY02_13175 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit GIY02_13180 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GIY02_13190 ENOG4105VEQ Cold shock protein GIY02_13195 ENOG4105MVF Transcriptional regulator GIY02_13200 ENOG4105D2S major facilitator superfamily GIY02_13205 ENOG4106JH6 (LipO)protein GIY02_13220 ENOG4105D7K pfkb domain protein GIY02_13230 ENOG4108M60 Transcriptional regulator GIY02_13235 ENOG4108ZG0 Ompa motb domain protein GIY02_13240 ENOG4107QY8 reductase GIY02_13245 ENOG4105HNP -acetyltransferase GIY02_13250 ENOG4108R3E Dna-3-methyladenine glycosylase i GIY02_13255 ENOG4105EAX Putative lipase GIY02_13260 ENOG4105FCD Major Facilitator GIY02_13265 ENOG4105DIJ Phosphoethanolamine transferase GIY02_13280 ENOG4105DEF Extracellular solute-binding protein, family 5 GIY02_13285 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GIY02_13290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GIY02_13295 ENOG4105C3U ABC transporter GIY02_13300 ENOG4108JQ7 (ABC) transporter GIY02_13315 ENOG4105D1V cellulose synthase operon protein YhjU GIY02_13320 ENOG4105WQA Cellulose biosynthesis protein BcsF GIY02_13325 ENOG4105U74 cellulose biosynthesis protein BcsE GIY02_13330 ENOG410661M cytoplasmic protein GIY02_13335 ENOG4105UTS cellulose synthase operon protein YhjQ GIY02_13340 ENOG4107QZ7 Cellulose synthase catalytic subunit GIY02_13345 ENOG4107EEX Cellulose synthase regulator protein GIY02_13350 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) GIY02_13355 ENOG4105EJG cellulose synthase GIY02_13360 ENOG4105BZU Histidine kinase GIY02_13370 ENOG4105CS0 peptidase GIY02_13380 ENOG41066T0 asmA family GIY02_13385 ENOG4105CSH Transporter GIY02_13390 ENOG4107H3J ribonuclease GIY02_13395 ENOG4105CBN LysR family transcriptional regulator GIY02_13400 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GIY02_13405 ENOG4106S2D Transcriptional regulator GIY02_13425 ENOG4105C0A alcohol dehydrogenase GIY02_13430 ENOG4108TGY Glutathione S-transferase GIY02_13435 ENOG4105ETE Transcriptional regulator (LacI family GIY02_13440 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GIY02_13445 ENOG4105CY2 Citrate transporter GIY02_13455 ENOG4105DC8 reductase GIY02_13460 ENOG4105D6S protein involved in catabolism of external DNA GIY02_13465 ENOG4105DGW oligopeptidase A GIY02_13470 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) GIY02_13475 ENOG4105DUX Transporter GIY02_13480 ENOG4108M6U Universal stress protein A GIY02_13490 ENOG4105CJ3 phosphate transporter GIY02_13495 ENOG4105CBX hi0933 family GIY02_13500 ENOG4105CJW magnesium transporter GIY02_13525 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) GIY02_13530 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GIY02_13535 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GIY02_13540 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GIY02_13550 ENOG4105PY6 Phenolic acid decarboxylase GIY02_13560 ENOG4105CKK Glycosyl transferase, family 2 GIY02_13570 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) GIY02_13575 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) GIY02_13585 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) GIY02_13590 ENOG4107YAK holo-(acyl carrier protein) synthase 2 GIY02_13600 ENOG4105C2D reductase GIY02_13605 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GIY02_13610 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GIY02_13675 ENOG4105F9N Major Facilitator Superfamily GIY02_13680 ENOG4108W1V Lipoprotein GIY02_13685 ENOG4105EX9 Membrane GIY02_13700 ENOG4107FS9 Membrane GIY02_13710 ENOG4105MG3 Membrane GIY02_13715 ENOG4106H78 methyltransferase GIY02_13720 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GIY02_13725 ENOG4105CAK Cell division ATP-binding protein ftsE GIY02_13730 ENOG4105CRP Part of the ABC transporter FtsEX involved in GIY02_13740 ENOG4105CP9 extracellular ligand-binding receptor GIY02_13745 ENOG4105U59 -acetyltransferase GIY02_13755 ENOG4105CP9 extracellular ligand-binding receptor GIY02_13760 ENOG4105C32 Amino acid ABC transporter (Permease) GIY02_13765 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GIY02_13770 ENOG4105C0Z ABC transporter GIY02_13775 ENOG4108IV0 ABC, transporter GIY02_13780 ENOG41060M8 Pfam:PhdYeFM GIY02_13790 ENOG4105BZ7 extracellular solute-binding protein family 1 GIY02_13795 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component GIY02_13810 ENOG4107T6V glycerophosphoryl diester phosphodiesterase GIY02_13815 ENOG4105WC8 Conserved Protein GIY02_13820 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GIY02_13825 ENOG4105WCN acetyltransferase GIY02_13835 ENOG4105D9R oxidoreductase GIY02_13840 ENOG4105C2I pirin domain protein GIY02_13845 ENOG4105DIQ Transcriptional regulator GIY02_13855 ENOG4105C6Z Gluconate GIY02_13860 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GIY02_13865 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GIY02_13885 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GIY02_13890 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GIY02_13900 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) GIY02_13905 ENOG4105E98 transcriptional regulator DeoR family GIY02_13915 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GIY02_13920 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) GIY02_13925 ENOG4105C6Z Gluconate GIY02_13935 ENOG4105MJ2 Competence protein GIY02_13940 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GIY02_13950 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) GIY02_13960 ENOG4105XFK Ferrous iron transport protein A GIY02_13965 ENOG4105BZM domain protein GIY02_13970 ENOG4108RRZ Transcription elongation factor GreB GIY02_13980 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GIY02_13985 ENOG4105ERH Fumarylacetoacetate hydrolase GIY02_13990 ENOG4105DIA mandelate racemase muconate lactonizing GIY02_14005 ENOG4105QJH Domain of unknown function (DUF718) GIY02_14010 ENOG4105EDR glucose galactose transporter GIY02_14015 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GIY02_14020 ENOG4105E0F Histidine kinase GIY02_14035 ENOG4105VEJ Heat shock protein GIY02_14040 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 GIY02_14045 ENOG4105DQY intracellular growth attenuator GIY02_14050 ENOG4107RK2 ADP-ribose diphosphatase NudE GIY02_14070 ENOG4108JQC penicillin-binding protein 1A GIY02_14095 ENOG4105E4G Type IV pilus GIY02_14100 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GIY02_14110 ENOG4105EGB membrane protein DamX GIY02_14115 ENOG4105DFE Dna adenine methylase GIY02_14120 ENOG4105DJV ribulose-phosphate 3-epimerase GIY02_14130 ENOG4105C31 Tryptophanyl-tRNA synthetase GIY02_14135 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GIY02_14140 ENOG4105WZK nitrite reductase NADPH small subunit GIY02_14145 ENOG4107QZF nitrite reductase NADPH large subunit GIY02_14150 ENOG4105DZC cytosine deaminase GIY02_14155 ENOG4106DTQ Protein TsgA homolog GIY02_14160 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GIY02_14165 ENOG4106195 uncharacterized protein yhfG GIY02_14170 ENOG4105MZU cell filamentation protein GIY02_14180 ENOG4105C8Y Acetylornithine aminotransferase GIY02_14185 ENOG410613R integral membrane protein, YccS YhfK family GIY02_14195 ENOG4108UKZ OsmC family GIY02_14200 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) GIY02_14210 ENOG4105DNZ Alpha Beta Hydrolase GIY02_14215 ENOG4105C5H ABC transporter GIY02_14220 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GIY02_14230 ENOG4105VKU nucleicacid-binding protein GIY02_14235 ENOG4108YZY peptidylprolyl cis-trans isomerase GIY02_14245 ENOG4108V1T peptidylprolyl cis-trans isomerase GIY02_14250 ENOG4105WWK YheO domain protein GIY02_14255 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) GIY02_14260 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GIY02_14275 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GIY02_14280 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GIY02_14285 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GIY02_14290 ENOG4105W53 bacterioferritin-associated ferredoxin GIY02_14295 ENOG4108UQY Iron-storage protein GIY02_14310 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GIY02_14315 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GIY02_14330 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GIY02_14340 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GIY02_14345 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GIY02_14355 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GIY02_14360 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GIY02_14395 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GIY02_14400 ENOG4105VPB 50S ribosomal protein L30 GIY02_14410 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GIY02_14415 ENOG41067V7 50S ribosomal protein L36 GIY02_14425 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GIY02_14435 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GIY02_14445 ENOG4105VTS DnaJ-like, subfamily C GIY02_14450 ENOG4105W1Y Transcriptional regulator GIY02_14455 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system GIY02_14465 ENOG4105C1A potassium transporter peripheral membrane GIY02_14470 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GIY02_14475 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GIY02_14485 ENOG4105C79 DNA protecting protein DprA GIY02_14495 ENOG4108WI1 Dna topoisomerase GIY02_14500 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GIY02_14505 ENOG4105E2X shikimate dehydrogenase GIY02_14510 ENOG4105SG3 Protein of unknown function (DUF1488) GIY02_14515 ENOG4108Z0R Transferase GIY02_14545 ENOG4105XCM membrane LIPOPROTEIN GIY02_14550 ENOG4105BZS acriflavin resistance protein GIY02_14555 ENOG4105C1P efflux transporter, rnd family, mfp subunit GIY02_14560 ENOG4108XG4 DNA-binding transcriptional regulator GIY02_14565 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) GIY02_14570 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GIY02_14580 ENOG4108IA2 Sodium pantothenate symporter GIY02_14585 ENOG4105RG0 Membrane GIY02_14590 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GIY02_14595 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GIY02_14600 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GIY02_14615 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GIY02_14620 ENOG41062P1 Diguanylate cyclase phosphodiesterase GIY02_14625 ENOG4105DFF Rod shape-determining protein mreb GIY02_14630 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GIY02_14635 ENOG4105VQ7 Rod shape-determining protein MreD GIY02_14645 ENOG4105C03 ribonuclease GIY02_14650 ENOG4105QD6 exported protein GIY02_14655 ENOG4105D1U peptidase U62 modulator of DNA gyrase GIY02_14660 ENOG4105CR8 Transcriptional regulator GIY02_14675 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) GIY02_14680 ENOG4105UNR (Barnase) inhibitor GIY02_14685 ENOG4105RID UPF0379 protein yhcN GIY02_14690 ENOG4105RID UPF0379 protein yhcN GIY02_14715 ENOG4105C0H protease GIY02_14720 ENOG4105C0H protease GIY02_14725 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III GIY02_14730 ENOG4105D6Z AFG1 family ATPase GIY02_14740 ENOG4108UJD 30S ribosomal protein S9 GIY02_14745 ENOG4107MKT Stringent starvation protein a GIY02_14750 ENOG4105KB2 stringent starvation protein b GIY02_14755 ENOG4105BZ8 glutamate synthase GIY02_14760 ENOG4105CBC glutamate synthase GIY02_14765 ENOG4105N5T Radical SAM Protein GIY02_14770 ENOG4105BZU Histidine kinase GIY02_14775 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain GIY02_14785 ENOG41080Z8 PHOSPHOCARRIER protein GIY02_14795 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GIY02_14800 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA GIY02_14805 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GIY02_14810 ENOG4108IUZ ABC transporter GIY02_14815 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA GIY02_14820 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) GIY02_14825 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase GIY02_14830 ENOG4105C2X Arabinose 5-phosphate isomerase GIY02_14835 ENOG4105FEU K -dependent Na -Ca exchanger GIY02_14840 ENOG4105DHJ ABC, transporter GIY02_14845 ENOG4105CY3 ABC transporter, permease GIY02_14850 ENOG4107PE3 Mammalian cell entry related domain protein GIY02_14855 ENOG4105E3I toluene tolerance GIY02_14860 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane GIY02_14865 ENOG4105VFK BolA family GIY02_14870 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GIY02_14875 ENOG4105HVQ Regulatory factor of maltose metabolism GIY02_14880 ENOG4105EAH synthase GIY02_14895 ENOG4105QYV Membrane GIY02_14905 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase GIY02_14910 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GIY02_14915 ENOG4105HBR Rna-binding protein GIY02_14940 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GIY02_14970 ENOG4108UII YfaZ family GIY02_14975 ENOG4108PNB DNA-binding transcriptional regulator GIY02_14980 ENOG4105CDH Citrulline--aspartate ligase GIY02_14995 ENOG4105CHV Transcription elongation factor NusA GIY02_15010 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GIY02_15015 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GIY02_15035 ENOG4105C1J atp-dependent rna helicase GIY02_15040 ENOG4105CIC tryptophan-specific transport protein GIY02_15045 ENOG4105DEN Luciferase family GIY02_15050 ENOG4106RZ4 Peptidase U32 GIY02_15055 ENOG4105CFP Peptidase U32 GIY02_15060 ENOG4105XPQ lipid carrier protein GIY02_15065 ENOG4108YYD acetyltransferase GIY02_15070 ENOG41082IR Excinuclease ABC C subunit domain protein GIY02_15075 ENOG4108ZPB UPF0306 protein GIY02_15080 ENOG4107R7Y intracellular protease Pfpi family GIY02_15085 ENOG4105K4T epimerase GIY02_15090 ENOG4107S21 permease GIY02_15095 ENOG4105W4M Transport-associated protein GIY02_15110 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) GIY02_15115 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GIY02_15130 ENOG4105E70 isomerase GIY02_15135 ENOG4105CE4 GlcNAc 6-P deacetylase GIY02_15140 ENOG4108YTN IIa component GIY02_15145 ENOG4105F3R pts system mannose fructose sorbose family iid GIY02_15155 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB GIY02_15165 ENOG4105E98 transcriptional regulator DeoR family GIY02_15170 ENOG4105CTX dehydratase GIY02_15175 ENOG4105CNV Aldolase GIY02_15180 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GIY02_15185 ENOG4105BZW Glycerate kinase GIY02_15195 ENOG4105D64 Mechanosensitive ion channel GIY02_15205 ENOG4106D80 Uncharacterized protein YhaL GIY02_15210 ENOG4108CNN domain protein GIY02_15215 ENOG4105CWB LysR family transcriptional Regulator GIY02_15220 ENOG4105KAF membrAne GIY02_15225 ENOG4105CHF Glutathione S-transferase GIY02_15230 ENOG4108VBZ doxx family GIY02_15240 ENOG4105YJD GIY02_15245 ENOG41090KG Inner membrane protein YqjE GIY02_15250 ENOG4105NE1 Conserved Protein GIY02_15255 ENOG4105WAY exported protein GIY02_15260 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) GIY02_15265 ENOG4106W5V Membrane GIY02_15270 ENOG4107YCY Transcriptional regulator GIY02_15275 ENOG4105DPW Major facilitator superfamily MFS_1 GIY02_15285 ENOG4105CTX dehydratase GIY02_15295 ENOG4105DU1 integral membrane protein, terc GIY02_15300 ENOG4105EE0 oxidoreductase GIY02_15305 ENOG4108VKG metal-dependent hydrolase GIY02_15315 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GIY02_15320 ENOG4107RYS Autoinducer-2 (AI-2) kinase GIY02_15325 ENOG4105DKT Transcriptional regulator GIY02_15330 ENOG4105C2J ABC transporter GIY02_15335 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GIY02_15340 ENOG4105F5R ABC transporter GIY02_15345 ENOG4105D4B ABC, transporter GIY02_15350 ENOG41061GT Aldolase GIY02_15355 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound GIY02_15360 ENOG4107WCA isomerase GIY02_15365 ENOG4107W6W Conserved Protein GIY02_15370 ENOG4105E5D amino acid GIY02_15375 ENOG4105E5D amino acid GIY02_15380 ENOG4105FK9 beta-D-galactosidase beta subunit GIY02_15385 ENOG4105CNT hydrolase family 2 GIY02_15390 ENOG4105CQ4 Transcriptional regulator GIY02_15395 ENOG4108Y51 tRNA-binding protein GIY02_15400 ENOG4105C8Y Acetylornithine aminotransferase GIY02_15405 ENOG4105NTW Transcriptional regulator GIY02_15410 ENOG4105Q26 Siderophore-interacting protein GIY02_15425 ENOG4108UTZ Dihydroxyacetone kinase GIY02_15430 ENOG4105CMT Dihydroxyacetone kinase GIY02_15475 ENOG4105F5H Glycosyl Hydrolase Family 88 GIY02_15480 ENOG4105TW1 Carbohydrate-selective porin OprB GIY02_15485 ENOG41079KZ Major Facilitator Superfamily GIY02_15495 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GIY02_15500 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GIY02_15505 ENOG4105V2F Uncharacterized protein yoac GIY02_15515 ENOG4108VCA G U mismatch-specific DNA glycosylase GIY02_15520 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GIY02_15525 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GIY02_15530 ENOG4105VCC 30S ribosomal protein S21 GIY02_15540 ENOG4105C54 Major Facilitator superfamily GIY02_15545 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GIY02_15550 ENOG4107ZVW dihydroneopterin aldolase GIY02_15560 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GIY02_15565 ENOG4106MWK domain protein GIY02_15570 ENOG4105I7R Adenylate cyclase GIY02_15590 ENOG4105W0Z cytoplasmic protein GIY02_15600 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GIY02_15605 ENOG4106032 Glutathionylspermidine synthase GIY02_15610 ENOG4105F1G UPF0441 protein GIY02_15620 ENOG41087AY ADP-Ribose pyrophosphatase GIY02_15625 ENOG4108SX3 cytoplasmic protein GIY02_15630 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GIY02_15635 ENOG4105IPS esterase GIY02_15645 ENOG4105VRH Antibiotic biosynthesis monooxygenase GIY02_15650 ENOG4105NF4 modulator of drug activity GIY02_15655 ENOG4105DHQ Histidine kinase GIY02_15660 ENOG4105XJC Two component transcriptional regulator (Winged helix family GIY02_15665 ENOG4105H4F exported protein GIY02_15670 ENOG4105F4I Transcriptional regulator GIY02_15675 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GIY02_15680 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase GIY02_15685 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) GIY02_15690 ENOG4105CCT upf0313 protein GIY02_15700 ENOG4105CV8 reductase GIY02_15705 ENOG4108I6A alcohol dehydrogenase GIY02_15710 ENOG4105CF7 AraC family transcriptional regulator GIY02_15715 ENOG4108K81 inner membrane protein YghB GIY02_15720 ENOG4105C28 cystathionine GIY02_15725 ENOG4105CWK Biopolymer transport protein, ExbB GIY02_15730 ENOG4108ZZF transport protein (ExbD) GIY02_15735 ENOG4108TEB UPF0114 protein GIY02_15740 ENOG4105CYM Glutathione S-transferase GIY02_15750 ENOG4106032 Glutathionylspermidine synthase GIY02_15755 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GIY02_15770 ENOG4105DRR Transcriptional regulator, GntR family GIY02_15780 ENOG4108MXF Alpha Beta Hydrolase GIY02_15785 ENOG4105MXW flavin reductase domain protein, FMN-binding GIY02_15790 ENOG4108M8W Monooxygenase GIY02_15795 ENOG4105C26 Dehydrogenase GIY02_15800 ENOG4105ETS cytosine purines uracil thiamine allantoin GIY02_15810 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GIY02_15815 ENOG4105C26 Dehydrogenase GIY02_15830 ENOG4105EJC lysr family transcriptional regulator GIY02_15835 ENOG4109066 lysm domain bon superfamily protein GIY02_15840 ENOG4105VP5 Bacterial protein of unknown function (DUF937) GIY02_15845 ENOG4105ETS cytosine purines uracil thiamine allantoin GIY02_15850 ENOG4105E7U AraC family transcriptional regulator GIY02_15865 ENOG4105EP8 Glycosyl Hydrolase Family 88 GIY02_15875 ENOG4107RNH Outer membrane receptor FepA GIY02_15885 ENOG4105E93 esterase GIY02_15905 ENOG4108QBF Transcriptional regulator GIY02_15915 ENOG4105JHE Major Facilitator Superfamily GIY02_15925 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) GIY02_15930 ENOG4108R66 Conserved Protein GIY02_15935 ENOG4108WC9 type VI secretion system effector, hcp1 family GIY02_15950 ENOG4108UQV Membrane GIY02_15960 ENOG4105EAA nucleoside GIY02_15970 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) GIY02_15975 ENOG4105CEN a g-specific adenine glycosylase GIY02_15980 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GIY02_15985 ENOG41090ED Protein with unknown function (DUF469) GIY02_15990 ENOG4105K33 Periplasmic Protein GIY02_15995 ENOG4107RNG ABC transporter GIY02_16000 ENOG4105C2J ABC transporter GIY02_16010 ENOG4105CSA Coproporphyrinogen iii oxidase GIY02_16020 ENOG4105VZ9 UPF0235 protein GIY02_16025 ENOG4108VIA integral membrane protein GIY02_16030 ENOG4105DFA alanine racemase domain protein GIY02_16035 ENOG4105CZX twitching motility protein GIY02_16040 ENOG41086KC Transcriptional regulator GIY02_16050 ENOG4108UJU UPF0301 protein GIY02_16055 ENOG4105D7Z glutathione synthase GIY02_16060 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GIY02_16065 ENOG4105RWS endonuclease I GIY02_16075 ENOG4107QNK )-transporter GIY02_16080 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GIY02_16135 ENOG4105CHR reductase GIY02_16140 ENOG4108FUF Transcriptional regulator, IclR family GIY02_16150 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase GIY02_16170 ENOG4105CHR reductase GIY02_16175 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) GIY02_16190 ENOG4105J5J Outer membrane porin GIY02_16195 ENOG4108K0D peptidase, M48 GIY02_16200 ENOG4105CV1 Transketolase (EC 2.2.1.1) GIY02_16215 ENOG4105D2N Aldolase GIY02_16220 ENOG4105D64 Mechanosensitive ion channel GIY02_16225 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GIY02_16230 ENOG4105MPN Membrane GIY02_16245 ENOG4108JQ1 Dehydrogenase GIY02_16250 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GIY02_16265 ENOG4105E07 UPF0149 protein GIY02_16270 ENOG4107RAQ aminopeptidase GIY02_16275 ENOG4105D0A hydroxylase GIY02_16280 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GIY02_16285 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GIY02_16300 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GIY02_16305 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GIY02_16325 ENOG4105CS2 ec 3.2.1.21 GIY02_16330 ENOG4108Q3X Transcriptional regulator GIY02_16340 ENOG4108UT2 hemolysin iii GIY02_16350 ENOG4105Y75 tpr repeat protein GIY02_16355 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB GIY02_16360 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) GIY02_16365 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GIY02_16370 ENOG4105T95 Thiol disulfide interChange protein GIY02_16375 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GIY02_16385 ENOG4105CRK lysyL-tRNA synthetase GIY02_16415 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GIY02_16420 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GIY02_16435 ENOG4108TH4 Major fimbrial subunit GIY02_16445 ENOG4106PG1 outer membrane usher protein GIY02_16450 ENOG4108FZ9 Chaperone GIY02_16460 ENOG4108MDY Fimbrial GIY02_16475 ENOG4105CUT histidyl-tRNA synthetase GIY02_16480 ENOG4105CUT histidyl-tRNA synthetase GIY02_16485 ENOG4107SJ9 decarboxylase GIY02_16490 ENOG4105D5Q Arginine ornithine antiporter GIY02_16500 ENOG4107VGR Catalase GIY02_16505 ENOG4105ETE Transcriptional regulator (LacI family GIY02_16510 ENOG4105ECY inositol monophosphatase GIY02_16515 ENOG4105CXY transporter GIY02_16520 ENOG4105D6F Phosphatase GIY02_16545 ENOG4105WPN DNA integration recombination invertion protein GIY02_16550 ENOG41061MD high-affinity nickel-transporter GIY02_16560 ENOG4105D5Q Arginine ornithine antiporter GIY02_16565 ENOG4105CXN decarboxylase GIY02_16575 ENOG4105DUX Transporter GIY02_16580 ENOG4105ETP RND efflux system, outer membrane lipoprotein GIY02_16585 ENOG4108MI0 Resistance protein GIY02_16590 ENOG4105J12 Multidrug resistance protein mdtN GIY02_16600 ENOG4105VR1 Pfam:DUF1271 GIY02_16605 ENOG410830R acetyltransferase GIY02_16615 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin GIY02_16620 ENOG4108T65 Fimbrial GIY02_16625 ENOG4108SQA Fimbrial GIY02_16630 ENOG4105CW0 outer membrane usher protein GIY02_16635 ENOG4108NAE Fimbrial chaperone protein GIY02_16640 ENOG4108S54 Fimbrial protein GIY02_16645 ENOG4108RQP Major type 1 subunit fimbrin GIY02_16655 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off GIY02_16660 ENOG4108W9T type 1 fimbriae regulatory protein GIY02_16675 ENOG4105EW9 transcriptional regulator AsnC family GIY02_16685 ENOG41063W2 Fimbrial protein GIY02_16690 ENOG4108MQF Chaperone GIY02_16695 ENOG4105CW0 outer membrane usher protein GIY02_16710 ENOG4108VQN 4-hydroxyphenylacetate 3-monooxygenase reductase GIY02_16720 ENOG4105CHR reductase GIY02_16730 ENOG4105FUY alpha subunit GIY02_16740 ENOG4108KC1 acyl-Coa dehydrogenase GIY02_16745 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GIY02_16755 ENOG4108ZT1 Transcriptional regulator GIY02_16760 ENOG4108KTG Membrane protein, drug metabolite transporter GIY02_16775 ENOG4108ZHR arsR family transcriptional regulator GIY02_16790 ENOG4107S5I aldo keto reductase GIY02_16795 ENOG4108MHD transport protein GIY02_16805 ENOG4105DUM transcriptional regulator, lysR family GIY02_16810 ENOG4105CHU acetyl-coa acetyltransferase GIY02_16815 ENOG4105CHR reductase GIY02_16820 ENOG4107QNK )-transporter GIY02_16840 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GIY02_16845 ENOG4108HKT sucrose-6-phosphate hydrolase GIY02_16860 ENOG4105RQF LysR family Transcriptional regulator GIY02_16865 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GIY02_16870 ENOG4105DDV Transcriptional regulator (LacI family GIY02_16880 ENOG41060NJ transcriptional regulator GIY02_16890 ENOG4107S74 Lysophospholipid transporter LplT GIY02_16895 ENOG4105CPC Aldo Keto reductase GIY02_16900 ENOG4105SUV lipoprotein YgdR GIY02_16905 ENOG4105EE5 Membrane protein terC GIY02_16920 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase GIY02_16925 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GIY02_16930 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GIY02_16935 ENOG4105IPU prepilin peptidase dependent protein A GIY02_16940 ENOG4105JCS prepilin peptidase dependent protein GIY02_16945 ENOG4105SEN Protein of unknown function (DUF2509) GIY02_16955 ENOG4105DSY exodeoxyribonuclease V, gamma GIY02_16960 ENOG4107QXK peptidase GIY02_16965 ENOG4107QKA exodeoxyribonuclease V beta GIY02_16970 ENOG4107QYX exodeoxyribonuclease v alpha GIY02_16975 ENOG4107QZM n-acetylglutamate synthase GIY02_16980 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GIY02_17000 ENOG4105CA3 membrane-bound lytic murein transglycosylase GIY02_17005 ENOG4105CUZ uba thif-type nad fad binding protein GIY02_17010 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GIY02_17015 ENOG4105C9B Cysteine desulfurase GIY02_17020 ENOG4105ETT transcriptional Regulator, LysR family GIY02_17025 ENOG4105M08 Membrane GIY02_17040 ENOG4105EJQ L-serine dehydratase GIY02_17045 ENOG4105C44 Serine transporter GIY02_17050 ENOG4105EWT decarboxylase family GIY02_17060 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) GIY02_17065 ENOG4105WP7 tRNA pseudouridine synthase C GIY02_17070 ENOG4105DR9 pseudouridine synthase GIY02_17075 ENOG4105QDK Flavodoxin GIY02_17085 ENOG4105DJB Major Facilitator Superfamily GIY02_17090 ENOG4105EQX glucarate dehydratase GIY02_17095 ENOG4105EQX glucarate dehydratase GIY02_17100 ENOG4105BZW Glycerate kinase GIY02_17110 ENOG4105BZU Histidine kinase GIY02_17120 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GIY02_17125 ENOG4105DXN mazG family GIY02_17130 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GIY02_17145 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GIY02_17150 ENOG4105CHR reductase GIY02_17155 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GIY02_17160 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GIY02_17170 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GIY02_17175 ENOG4108MXK alkaline phosphatase isozyme conversion GIY02_17180 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GIY02_17200 ENOG4105N0Z inner membrane protein ygbE GIY02_17205 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GIY02_17220 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) GIY02_17230 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GIY02_17235 ENOG4108K5P (LipO)protein GIY02_17240 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GIY02_17250 ENOG4105JQN Transcriptional regulator GIY02_17260 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GIY02_17265 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GIY02_17270 ENOG4105KZM cytoplasmic protein GIY02_17280 ENOG4108VCD Chaperone GIY02_17285 ENOG4105CW0 outer membrane usher protein GIY02_17305 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GIY02_17310 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GIY02_17315 ENOG4105EHG Permease protein GIY02_17320 ENOG4107R4I Periplasmic binding protein GIY02_17325 ENOG4106QJH hemin transport protein GIY02_17345 ENOG4108N2Y auxin Efflux GIY02_17350 ENOG4107R11 Transcriptional regulator GIY02_17355 ENOG4105VXR cytoplasmic protein GIY02_17360 ENOG4105CC5 ABC transporter GIY02_17365 ENOG4105CC5 ABC transporter GIY02_17370 ENOG4105DIK (ABC) transporter GIY02_17385 ENOG4105C45 hydrogenase expression formation protein (HypE) GIY02_17390 ENOG4105CQS hydrogenase expression formation protein HypD GIY02_17395 ENOG41083WG hydrogenase assembly chaperone GIY02_17400 ENOG4107RSS Hydrogenase accessory protein HypB GIY02_17405 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) GIY02_17410 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA GIY02_17415 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) GIY02_17420 ENOG4107R30 NADH dehydrogenase GIY02_17425 ENOG4107TDF Formate hydrogenlyase subunit 4 GIY02_17430 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GIY02_17435 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit GIY02_17440 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit GIY02_17445 ENOG4105I6X formate hydrogenlyase maturation GIY02_17450 ENOG4108MG9 hydrogenase 3 maturation protease GIY02_17455 ENOG4105CS2 ec 3.2.1.21 GIY02_17460 ENOG4105C5Y PTS System GIY02_17465 ENOG4105DDV Transcriptional regulator (LacI family GIY02_17470 ENOG4108RC0 Electron transport protein GIY02_17475 ENOG4105C8H hydrogenase maturation protein Hypf GIY02_17490 ENOG4105CNW domain protein GIY02_17505 ENOG410804X Transcriptional regulator GIY02_17510 ENOG4105J92 DNA-binding transcriptional activator GutM GIY02_17515 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase GIY02_17520 ENOG4105VI0 Pts system, glucitol sorbitol-specific GIY02_17525 ENOG4105DZY Pts system, glucitol sorbitol-specific GIY02_17530 ENOG410787A Pts system, glucitol sorbitol-specific GIY02_17535 ENOG4105CVE Lytic murein transglycosylase GIY02_17545 ENOG4105DIK (ABC) transporter GIY02_17550 ENOG4105CC5 ABC transporter GIY02_17555 ENOG4105DSE periplasmic solute binding protein GIY02_17560 ENOG4107TH8 cina domain protein GIY02_17575 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GIY02_17580 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GIY02_17610 ENOG4105K3G Periplasmic Protein GIY02_17615 ENOG4107VXZ Hydrolase GIY02_17620 ENOG4105W39 Membrane GIY02_17635 ENOG4105E7U AraC family transcriptional regulator GIY02_17640 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GIY02_17645 ENOG4105C0R drug resistance transporter emrb qaca subfamily GIY02_17650 ENOG4105CW7 secretion protein, HlyD family GIY02_17655 ENOG4105NTK Transcriptional repressor Mpra GIY02_17660 ENOG4105GIJ Glycine betaine GIY02_17665 ENOG4108HQS Glycine betaine GIY02_17670 ENOG4108IJ7 Glycine betaine GIY02_17675 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GIY02_17680 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GIY02_17685 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GIY02_17690 ENOG4105WAZ (Glutaredoxin-like protein) NrdH GIY02_17695 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GIY02_17705 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) GIY02_17710 ENOG4108WMJ Protein of unknown function (DUF2002) GIY02_17715 ENOG4108RNS Exports L-alanine (By similarity) GIY02_17720 ENOG4108X73 DNA- binding protein GIY02_17735 ENOG4108V62 Rhodanese domain protein GIY02_17740 ENOG41080HT Transcriptional regulator, arsr family GIY02_17750 ENOG4105CC0 LysR family Transcriptional regulator GIY02_17755 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GIY02_17760 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GIY02_17765 ENOG4105C26 Dehydrogenase GIY02_17770 ENOG4107H6U ABC transporter GIY02_17775 ENOG4105C3U ABC transporter GIY02_17780 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GIY02_17785 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GIY02_17790 ENOG4105DEF Extracellular solute-binding protein, family 5 GIY02_17795 ENOG4108UQS dipeptidase GIY02_17825 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GIY02_17830 ENOG4105CY0 Metallo-Beta-Lactamase GIY02_17835 ENOG4105EGI Transcriptional regulator GIY02_17845 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) GIY02_17850 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GIY02_17855 ENOG41060IM Heme exporter protein GIY02_17860 ENOG4105X3C heme exporter protein GIY02_17870 ENOG4105DA4 cytochrome c-type biogenesis protein GIY02_17875 ENOG4107QX9 Thiol disulfide interChange protein GIY02_17880 ENOG4105KWW Biogenesis protein GIY02_17885 ENOG4105KWW Biogenesis protein GIY02_17890 ENOG4105CUW cytochrome C-TYPE protein GIY02_17895 ENOG4107QY8 reductase GIY02_17905 ENOG4105XDF Protein of unknown function (DUF1272) GIY02_17925 ENOG4105NAE bifunctional deaminase-reductase domain protein GIY02_17960 ENOG4105DFP Integrase GIY02_17975 ENOG4108Z1B Cyclase dehydrase GIY02_17985 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GIY02_17990 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GIY02_18000 ENOG4108JU6 CBS domain protein GIY02_18005 ENOG4106KVJ cytochrome C assembly protein GIY02_18010 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GIY02_18015 ENOG4105K5M 30s ribosomal protein S16 GIY02_18020 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GIY02_18030 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GIY02_18045 ENOG41090EK ompa motb domain protein GIY02_18050 ENOG4108KHX Diguanylate cyclase GIY02_18055 ENOG4108WS1 GIY02_18060 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GIY02_18065 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GIY02_18075 ENOG4105CQC Prephenate dehydratase GIY02_18085 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA GIY02_18090 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GIY02_18095 ENOG4105C34 Pseudouridine synthase GIY02_18100 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GIY02_18105 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GIY02_18130 ENOG4105CSH Transporter GIY02_18135 ENOG4105T42 (LipO)protein GIY02_18140 ENOG4105JIM Phosphatidylserine synthase GIY02_18145 ENOG4105CD5 CoA-binding domain protein GIY02_18150 ENOG4106IUH DTW domain containing protein GIY02_18155 ENOG4105K63 Thioredoxin GIY02_18160 ENOG4105EIB trna rrna methyltransferase GIY02_18165 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GIY02_18175 ENOG4105C1J atp-dependent rna helicase GIY02_18185 ENOG4108IYU L-aspartate oxidase GIY02_18200 ENOG41069PW sigma-e factor negative regulatory protein GIY02_18205 ENOG4105VQK sigma E regulatory protein, MucB RseB GIY02_18210 ENOG4105WMJ Positive regulator of sigma E, RseC MucC GIY02_18220 ENOG4105C3F Signal peptidase i GIY02_18230 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GIY02_18235 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) GIY02_18240 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) GIY02_18250 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding GIY02_18255 ENOG4106G6Q Transcriptional regulator GIY02_18265 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB GIY02_18270 ENOG4108Z6B deaminase GIY02_18275 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GIY02_18280 ENOG4108ETH Formylglycinamide ribotide synthetase GIY02_18285 ENOG4107WP9 Histidine kinase GIY02_18290 ENOG4108SKK alpha helix protein GIY02_18295 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GIY02_18300 ENOG4108YZA Nitrogen regulatory protein pii GIY02_18305 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GIY02_18315 ENOG4108SB3 DoxX Family GIY02_18320 ENOG4105D8G Major Facilitator superfamily GIY02_18325 ENOG4108MN2 Stationary phase inducible protein CsiE GIY02_18330 ENOG41065CD Exported protein GIY02_18335 ENOG4105D7X high-affinity nickel-transporter GIY02_18340 ENOG4105ECY inositol monophosphatase GIY02_18345 ENOG4105CVS RNA methyltransferase TrmH family, group 1 GIY02_18350 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family GIY02_18360 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GIY02_18380 ENOG4108ZIT Ferredoxin, 2FE-2S GIY02_18385 ENOG4105WVQ Fe-S assembly protein IscX GIY02_18395 ENOG4105YYA enhanced serine sensitivity protein SseB GIY02_18400 ENOG4105KHC sulfurtransferase GIY02_18405 ENOG4105DN3 alpha-2-macroglobulin domain protein GIY02_18410 ENOG4108JQB penicillin-binding protein 1C GIY02_18430 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GIY02_18440 ENOG4105N21 Membrane GIY02_18450 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GIY02_18455 ENOG4105VPD cellular component movement GIY02_18465 ENOG4105D4Y metalloprotease GIY02_18475 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GIY02_18480 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GIY02_18505 ENOG41062G3 Protein of unknown function (DUF2633) GIY02_18510 ENOG4105BZU Histidine kinase GIY02_18515 ENOG4105C9X ppx gppa phosphatase GIY02_18520 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GIY02_18530 ENOG4105F5H Glycosyl Hydrolase Family 88 GIY02_18535 ENOG4105CT4 transporter GIY02_18545 ENOG4108V3E phosphoribosylglycinamide formyltransferase GIY02_18560 ENOG4105CS2 ec 3.2.1.21 GIY02_18570 ENOG4105C2W permease GIY02_18585 ENOG4105K89 arsenate reductase GIY02_18590 ENOG4105ERG peptidase m48, ste24p GIY02_18595 ENOG4105C02 permease GIY02_18600 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GIY02_18605 ENOG4105RH4 Glycine cleavage system transcriptional repressor GIY02_18610 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GIY02_18615 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GIY02_18625 ENOG4105CGZ zinc metallopeptidase GIY02_18635 ENOG4106KED esterase YpfH GIY02_18640 ENOG4105XYK UPF0370 protein GIY02_18645 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GIY02_18650 ENOG4105KUZ arsenate reductase GIY02_18660 ENOG4105BZS acriflavin resistance protein GIY02_18665 ENOG4105BZ8 glutamate synthase GIY02_18670 ENOG4107VIJ nudix hydrolase GIY02_18675 ENOG4108PVD exported protein GIY02_18680 ENOG4105CV1 Transketolase (EC 2.2.1.1) GIY02_18690 ENOG4105C6K Malic enzyme GIY02_18695 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) GIY02_18700 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase GIY02_18710 ENOG4105QZU Inner membrane protein YfeZ GIY02_18715 ENOG4105E7K (LipO)protein GIY02_18720 ENOG4105EZR dyp-type peroxidase family protein GIY02_18725 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein GIY02_18730 ENOG4108I5D sulfate abc transporter GIY02_18735 ENOG4105ECW sulfate abc transporter GIY02_18740 ENOG4108IJ6 ABC transporter GIY02_18745 ENOG4105C6T cysteine synthase GIY02_18750 ENOG41089BK Glutamine amido-transferase GIY02_18755 ENOG4105CSW GntR family transcriptional regulator GIY02_18770 ENOG4105C5Y PTS System GIY02_18780 ENOG4105KZ7 phosphocarrier protein hpr GIY02_18785 ENOG4105C6T cysteine synthase GIY02_18790 ENOG4105EXN Sulfate transport protein CysZ GIY02_18805 ENOG4105VRT cytoplasmic protein GIY02_18810 ENOG4105DHU Bile acid GIY02_18815 ENOG4108M0I Transcriptional regulator GIY02_18860 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GIY02_18865 ENOG4105GXM Putative transcription regulator (DUF1323) GIY02_18870 ENOG4105HZG regulatoR GIY02_18885 ENOG4108KMM Diguanylate cyclase GIY02_18890 ENOG4105D9N nucleoside GIY02_18895 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GIY02_18900 ENOG4109076 Conserved Protein GIY02_18905 ENOG4105CPC Aldo Keto reductase GIY02_18910 ENOG4107RA9 decarboxylase GIY02_18920 ENOG4105CHC glucokinase (EC 2.7.1.2) GIY02_18925 ENOG4105DY9 regulatoR GIY02_18930 ENOG4108HRK Histidine kinase GIY02_18935 ENOG4105CHM Aminotransferase GIY02_18945 ENOG4105DJ2 Major Facilitator Superfamily GIY02_18950 ENOG4107Y2X deaminase GIY02_18975 ENOG4105S64 Formate nitrite transporter GIY02_18980 ENOG410903C (LipO)protein GIY02_18985 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GIY02_18990 ENOG4105KZW UPF0381 protein GIY02_18995 ENOG4105CHU acetyl-coa acetyltransferase GIY02_19005 ENOG4108BY2 phosphohistidine phosphatase GIY02_19015 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GIY02_19020 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GIY02_19025 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) GIY02_19030 ENOG4105EJ9 Membrane GIY02_19035 ENOG4108BPE -transporting atpase GIY02_19040 ENOG4105MH2 YfcL protein GIY02_19045 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GIY02_19050 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GIY02_19055 ENOG4105F9N Major Facilitator Superfamily GIY02_19060 ENOG4105FDP GntR family transcriptional regulator GIY02_19070 ENOG4105CK1 PTS System GIY02_19075 ENOG4105VCP PTS System GIY02_19085 ENOG4108HCJ Hydrolase GIY02_19090 ENOG4106WZ1 flagella biosynthesis regulator GIY02_19100 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GIY02_19110 ENOG4105DQR SNARE associated Golgi GIY02_19115 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GIY02_19120 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GIY02_19125 ENOG4108S3P Sporulation domain protein GIY02_19130 ENOG4105E96 Colicin v production protein GIY02_19135 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase GIY02_19140 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GIY02_19150 ENOG4105E89 ABC transporter GIY02_19155 ENOG4105E89 ABC transporter GIY02_19160 ENOG4105DSP amino acid AbC transporter GIY02_19165 ENOG4106YG3 ABC transporter GIY02_19170 ENOG4108JEH abc transporter atp-binding protein GIY02_19190 ENOG4105ECP epimerase GIY02_19195 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase GIY02_19200 ENOG4105CYM Glutathione S-transferase GIY02_19205 ENOG4108SHQ Glutathione S-transferase GIY02_19210 ENOG4108RE9 Phosphodiesterase GIY02_19215 ENOG4105PTV Nudix Hydrolase GIY02_19220 ENOG4105C6K Malic enzyme GIY02_19225 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GIY02_19240 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 GIY02_19245 ENOG4107QWE )-transporter GIY02_19255 ENOG4105CHM Aminotransferase GIY02_19260 ENOG4107NQ8 LysR family Transcriptional regulator GIY02_19265 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GIY02_19275 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GIY02_19280 ENOG4105GKE subunit e GIY02_19285 ENOG4107QIZ NADH dehydrogenase GIY02_19290 ENOG4107R0R NADH dehydrogenase subunit g GIY02_19305 ENOG4107UFS subunit j GIY02_19315 ENOG4105D65 subunit l GIY02_19320 ENOG4105C8S subunit m GIY02_19325 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GIY02_19340 ENOG4107YB6 acetyltransferase, (GNAT) family GIY02_19345 ENOG4105E4F Isochorismate synthase GIY02_19350 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GIY02_19360 ENOG4108IPT Naphthoate synthase GIY02_19365 ENOG4105DNI Converts SHCHC to OSB (By similarity) GIY02_19370 ENOG4105CEY Amp-dependent synthetase and ligase GIY02_19395 ENOG4105DHQ Histidine kinase GIY02_19405 ENOG4108UII YfaZ family GIY02_19415 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GIY02_19425 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A GIY02_19430 ENOG4105CXY transporter GIY02_19435 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GIY02_19440 ENOG4105XPH Ferredoxin GIY02_19445 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GIY02_19450 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GIY02_19455 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GIY02_19460 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GIY02_19465 ENOG4105BZU Histidine kinase GIY02_19470 ENOG41068CG regulatoR GIY02_19475 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC GIY02_19495 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GIY02_19500 ENOG4105CF1 Alkylated DNA repair protein GIY02_19505 ENOG4105IBP Cyclic peptide transporter GIY02_19510 ENOG4105CJW magnesium transporter GIY02_19515 ENOG4105CHH sulfate transporter GIY02_19530 ENOG4105F4G Membrane GIY02_19540 ENOG4105E68 Sulfatase GIY02_19545 ENOG4105PAN UPF0352 protein GIY02_19550 ENOG4106V8H Nucleoid-associated protein GIY02_19560 ENOG4107VIJ nudix hydrolase GIY02_19580 ENOG4105CFI type iii restriction protein res subunit GIY02_19585 ENOG4105I08 Pseudouridine synthase GIY02_19590 ENOG4105C2C drug resistance transporter, Bcr CflA GIY02_19595 ENOG4105HG6 GIY02_19600 ENOG4108JQ5 ABC transporter GIY02_19605 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GIY02_19610 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component GIY02_19615 ENOG4105E43 Extracellular solute-binding protein, family 5 GIY02_19620 ENOG4105CXC rtn protein GIY02_19625 ENOG4107TT5 NLP P60 protein GIY02_19630 ENOG41076MN Phosphoesterase, PA-phosphatase related GIY02_19635 ENOG4105CKI cobalamin synthesis protein GIY02_19645 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GIY02_19655 ENOG4105KRS Proteinase inhibitor GIY02_19660 ENOG4105S8Q sugar efflux transporter GIY02_19670 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GIY02_19675 ENOG4105DE4 1-phosphofructokinase GIY02_19680 ENOG4105DM4 PTS System GIY02_19685 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GIY02_19690 ENOG4105HMI Membrane GIY02_19695 ENOG4105DUM transcriptional regulator, lysR family GIY02_19710 ENOG4108IQI permease GIY02_19715 ENOG4105D05 Receptor GIY02_19740 ENOG4105EUJ GTP cyclohydrolase i GIY02_19745 ENOG4105DHF Membrane GIY02_19750 ENOG41060NJ transcriptional regulator GIY02_19760 ENOG4105C2J ABC transporter GIY02_19765 ENOG4107SDZ Galactoside transport system permease protein mglC GIY02_19770 ENOG4107GZ4 SanA protein GIY02_19780 ENOG41067MG lrgb family GIY02_19785 ENOG4105VAW lrga family GIY02_19790 ENOG4106KR7 LysR family Transcriptional regulator GIY02_19810 ENOG4108RXX maleylacetoacetate isomerase GIY02_19815 ENOG4105MSY salicylate hydroxylase GIY02_19820 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) GIY02_19835 ENOG4105CS2 ec 3.2.1.21 GIY02_19840 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GIY02_19850 ENOG4105KHU inner membrane protein YohD GIY02_19855 ENOG41069YE inner membrane protein yohC GIY02_19860 ENOG41061WM D-Alanyl-D-Alanine GIY02_19870 ENOG4105CXG d-lactate dehydrogenase GIY02_19875 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GIY02_19880 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system GIY02_19885 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component GIY02_19890 ENOG4108IJ8 ABC transporter GIY02_19895 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component GIY02_19905 ENOG4108XDN Transcriptional regulator GIY02_19910 ENOG4108HRK Histidine kinase GIY02_19915 ENOG4108NEV two component transcriptional regulator, LytTR family GIY02_19920 ENOG4108W15 Protein of unknown function (DUF1456) GIY02_19925 ENOG4106GP0 (LipO)protein GIY02_19940 ENOG4105D1F ATP-binding protein GIY02_19950 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly GIY02_19955 ENOG4105EJC lysr family transcriptional regulator GIY02_19960 ENOG4105C7N Xanthine uracil vitamin C permease GIY02_19965 ENOG4105CPN adenine deaminase GIY02_19980 ENOG4105EUZ Beta-lactamase domain protein GIY02_19990 ENOG4105EUZ Beta-lactamase domain protein GIY02_20010 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase GIY02_20015 ENOG4105DWF phosphomethylpyrimidine kinase GIY02_20020 ENOG4105EIE fructose-bisphosphate aldolase GIY02_20025 ENOG4105IE8 Alpha-ketoglutarate permease GIY02_20030 ENOG4105CMG Carbohydrate kinase GIY02_20045 ENOG4105DKT Transcriptional regulator GIY02_20050 ENOG4105DEI Mannitol dehydrogenase GIY02_20055 ENOG4105CMG Carbohydrate kinase GIY02_20060 ENOG4105IE8 Alpha-ketoglutarate permease GIY02_20070 ENOG4105CFP Peptidase U32 GIY02_20075 ENOG4105E3W Two component transcriptional regulator (Winged helix family GIY02_20080 ENOG4105EB3 Histidine kinase GIY02_20085 ENOG4105C0R drug resistance transporter emrb qaca subfamily GIY02_20090 ENOG4105BZS acriflavin resistance protein GIY02_20100 ENOG4105ENT Efflux transporter rnd family, mfp subunit GIY02_20110 ENOG4105R8A Heat shock protein GIY02_20115 ENOG4105D03 DNA-3-methyladenine glycosylase II GIY02_20130 ENOG4108GAE asmA family GIY02_20135 ENOG4105EE5 Membrane protein terC GIY02_20140 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GIY02_20150 ENOG4105MH5 phosphoesterase PA-phosphatase related protein GIY02_20155 ENOG4108MRJ GIY02_20160 ENOG4105DAY polysaccharide export protein GIY02_20175 ENOG4105D3Q Sugar transferase GIY02_20180 ENOG4108KBE Glycosyl transferase, family 2 GIY02_20185 ENOG41090RK glycosyl transferase GIY02_20195 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GIY02_20200 ENOG4105PSV Polysaccharide Biosynthesis Protein GIY02_20235 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GIY02_20240 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GIY02_20265 ENOG4105C1B dTDP-glucose 4-6-dehydratase GIY02_20275 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GIY02_20285 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GIY02_20300 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GIY02_20305 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GIY02_20310 ENOG4105CIH Imidazole acetol-phosphate transaminase GIY02_20315 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GIY02_20330 ENOG4108535 NAD dependent epimerase/dehydratase family GIY02_20335 ENOG4105EQ1 Transcriptional regulator GIY02_20345 ENOG4105CUB amino acid GIY02_20350 ENOG4105YVS arsR family transcriptional regulator GIY02_20355 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GIY02_20360 ENOG4105CJB Exodeoxyribonuclease I GIY02_20365 ENOG4105EXC Acyl-transferase GIY02_20375 ENOG4105DZ1 carboxypeptidase GIY02_20385 ENOG4105DR8 Membrane GIY02_20395 ENOG4108YZT Adenosylcobinamide kinase GIY02_20410 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GIY02_20420 ENOG4108KMH lipoate-protein ligase a GIY02_20425 ENOG4105CSH Transporter GIY02_20435 ENOG4105BZU Histidine kinase GIY02_20440 ENOG4108YS1 cytoplasmic protein GIY02_20450 ENOG4105ETT transcriptional Regulator, LysR family GIY02_20470 ENOG4105UQX Mate efflux family protein GIY02_20510 ENOG4105CPF Cell wall formation (By similarity) GIY02_20515 ENOG4105EV4 Multidrug resistance protein mdtH GIY02_20520 ENOG4105FYV Amp nucleosidase GIY02_20540 ENOG4108TSE Transferase GIY02_20555 ENOG4107R11 Transcriptional regulator GIY02_20560 ENOG4108PXI ErfK YbiS YcfS YnhG GIY02_20585 ENOG4105WH1 Two component transcriptional regulator luxr family GIY02_20600 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GIY02_20605 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) GIY02_20610 ENOG4105C1G acyl-Coa dehydrogenase GIY02_20640 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GIY02_20665 ENOG4108VTW Thioesterase GIY02_20715 ENOG4108PCE TRANSFER protein GIY02_20795 ENOG4107ZSV Receptor GIY02_20800 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GIY02_20820 ENOG4105C0W non-ribosomal peptide synthetase GIY02_20835 ENOG4105BZ1 (ABC) transporter GIY02_20840 ENOG4105EYM Major Facilitator superfamily GIY02_20865 ENOG4105EHG Permease protein GIY02_20870 ENOG4105MYN Zinc uptake regulation protein GIY02_20880 ENOG4105CKI cobalamin synthesis protein GIY02_20890 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase GIY02_20895 ENOG4105C8N cysteinyl-tRNA synthetase GIY02_20910 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GIY02_20915 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) GIY02_20920 ENOG4108Z0R Transferase GIY02_20935 ENOG4105CC5 ABC transporter GIY02_20940 ENOG4105CC5 ABC transporter GIY02_20945 ENOG4105DIK (ABC) transporter GIY02_20950 ENOG4105DSE periplasmic solute binding protein GIY02_20955 ENOG4105C22 threonyL-tRNA synthetase GIY02_20965 ENOG4105CD3 dihydroorotase GIY02_20970 ENOG4105D52 delta-aminolevulinic acid dehydratase GIY02_20995 ENOG4105DSE periplasmic solute binding protein GIY02_21000 ENOG4105CC5 ABC transporter GIY02_21005 ENOG4105DIK (ABC) transporter GIY02_21055 ENOG4105EY8 ABC transporter GIY02_21060 ENOG4105MFV ABC-2 type transporter GIY02_21070 ENOG4105FCK Membrane GIY02_21075 ENOG4105Y0K Inner membrane protein YedR GIY02_21080 ENOG4105EST Metal Dependent Phosphohydrolase GIY02_21085 ENOG4105DVF Cytosine-specific methyltransferase GIY02_21090 ENOG41090BB DNA mismatch endonuclease (vsr) GIY02_21095 ENOG4105FDR Membrane GIY02_21100 ENOG4105CKW Inner membrane protein yedI GIY02_21105 ENOG4105VNZ cytoplasmic protein GIY02_21115 ENOG4105YX3 cellular response to acidity GIY02_21130 ENOG4105JCU Inherit from NOG: (Lipo)protein GIY02_21135 ENOG4105E5K Alpha-amylase GIY02_21140 ENOG4105EAB amino acid AbC transporter GIY02_21150 ENOG4105E5Q amino acid AbC transporter GIY02_21155 ENOG4105CDA abc transporter atp-binding protein GIY02_21160 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F GIY02_21165 ENOG4105VJY transcriptional regulator GIY02_21170 ENOG4105XVG cytoplasmic protein GIY02_21175 ENOG4105WH1 Two component transcriptional regulator luxr family GIY02_21205 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GIY02_21210 ENOG4105KAF membrAne GIY02_21215 ENOG4106RHG Yeca family GIY02_21220 ENOG4105E0U tyrosine-specific transport protein GIY02_21225 ENOG4105VVZ metal-binding protein GIY02_21230 ENOG41090A1 ferritin GIY02_21240 ENOG4105C0R drug resistance transporter emrb qaca subfamily GIY02_21245 ENOG4105N4N Protein of unknown function (DUF2766) GIY02_21250 ENOG4108UEC Ferritin-like protein GIY02_21255 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator GIY02_21265 ENOG4105CNN ABC, transporter GIY02_21270 ENOG4108K4C ec 3.1.3.12 GIY02_21275 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase GIY02_21280 ENOG4108VA4 Universal stress protein GIY02_21290 ENOG4105CT4 transporter GIY02_21295 ENOG4105F5H Glycosyl Hydrolase Family 88 GIY02_21300 ENOG4105C75 arginyL-tRNA synthetase GIY02_21305 ENOG4106ZCM YecM protein GIY02_21325 ENOG4105WJG Glutathione GIY02_21330 ENOG41081XQ Conserved Protein GIY02_21335 ENOG4105D3W isochorismatase GIY02_21340 ENOG4105C9M aspartyl-trna synthetase GIY02_21345 ENOG4108TIT dATP pyrophosphohydrolase GIY02_21365 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GIY02_21370 ENOG4105FAV ABC, transporter GIY02_21375 ENOG4105FDK ABC transporter GIY02_21380 ENOG4105NXV High-affinity zinc uptake system protein GIY02_21385 ENOG4105DR5 peptidase GIY02_21390 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase GIY02_21395 ENOG4105CA9 Pyruvate kinase GIY02_21400 ENOG4106KNT transcriptional regulator GIY02_21405 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GIY02_21410 ENOG4105C01 Dihydroxy-acid dehydratase GIY02_21415 ENOG4108UHU Aldolase GIY02_21425 ENOG4105X2V dna damage-inducible protein GIY02_21430 ENOG4108Q2J Inner membrane protein YebE GIY02_21435 ENOG4105CUG Oligopeptidase b GIY02_21440 ENOG4105UMD exodeoxyribonuclease X GIY02_21445 ENOG4105MPK DNA polymerase III subunit theta GIY02_21450 ENOG4105FXM Copper resistance protein GIY02_21455 ENOG4108PNC copper resistance GIY02_21460 ENOG4105NKT exported protein GIY02_21505 ENOG41087BU transcriptional repressor DicA GIY02_21530 ENOG4105JBR DNA replication protein GIY02_21555 ENOG4108R1E Serine threonine protein phosphatase 1 GIY02_21560 ENOG4105UVW uncharacterized protein yebW GIY02_21565 ENOG4105WT8 Protein of unknown function (DUF1480) GIY02_21575 ENOG4105DY2 Paraquat-inducible protein b GIY02_21580 ENOG4105H2K paraquat-inducible protein a GIY02_21585 ENOG4108ZGC gaf domain protein GIY02_21590 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) GIY02_21595 ENOG4105CN1 protease GIY02_21600 ENOG4105D0M Protease HtpX homolog GIY02_21605 ENOG4105C0R drug resistance transporter emrb qaca subfamily GIY02_21610 ENOG4105J4Q Transcriptional regulator GIY02_21615 ENOG4105TIK GIY02_21625 ENOG4105Q3Y exported protein GIY02_21630 ENOG410610J Protein of unknown function (DUF2627) GIY02_21635 ENOG4105VEQ Cold shock protein GIY02_21640 ENOG4105CJN penicillin-binding protein GIY02_21645 ENOG4105DHI Methyltransferase GIY02_21650 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) GIY02_21655 ENOG4108NK4 UPF0266 membrane protein GIY02_21660 ENOG4105F3R pts system mannose fructose sorbose family iid GIY02_21665 ENOG4105ETZ PTS System GIY02_21670 ENOG4108EQA pts system GIY02_21675 ENOG4105EE5 Membrane protein terC GIY02_21680 ENOG4107XTP (EAL) domain protein GIY02_21685 ENOG4105EJQ L-serine dehydratase GIY02_21690 ENOG4105P8F nudix hydrolase GIY02_21700 ENOG4105X5C UPF0181 protein GIY02_21705 ENOG4105M4H endoribonuclease L-psp GIY02_21710 ENOG4105DVT helicase GIY02_21715 ENOG41072GX Peptidase M22 Glycoprotease GIY02_21720 ENOG4105Y4Z Outer Membrane Lipoprotein GIY02_21725 ENOG4105CEY Amp-dependent synthetase and ligase GIY02_21730 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GIY02_21740 ENOG4107QMS site-determining protein GIY02_21745 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GIY02_21750 ENOG4105VNG YcgL domain-containing protein GIY02_21755 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GIY02_21765 ENOG4107R08 Integrase GIY02_21785 ENOG4105NI8 Cytosine-specific methyltransferase GIY02_21805 ENOG4105UMD exodeoxyribonuclease X GIY02_21880 ENOG4108MA7 Inherit from COG: YD repeat protein GIY02_21895 ENOG4105NY2 NinB protein GIY02_21940 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 GIY02_21990 ENOG4108TFU terminase (Small subunit) GIY02_22125 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GIY02_22135 ENOG4108RAV Conserved protein GIY02_22155 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) GIY02_22160 ENOG4105ED1 spovr family GIY02_22175 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GIY02_22180 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GIY02_22185 ENOG4106JQ5 Transglycosylase SLT domain GIY02_22190 ENOG4105E0K tonB-dependent siderophore receptor GIY02_22205 ENOG4105C2C drug resistance transporter, Bcr CflA GIY02_22210 ENOG410811B TRANSCRIPTIONal GIY02_22215 ENOG4105C7B Threonine dehydratase GIY02_22225 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GIY02_22230 ENOG4105C6N Formate acetyltransferase GIY02_22235 ENOG4105EJQ L-serine dehydratase GIY02_22240 ENOG4105D3G Pseudouridine synthase GIY02_22245 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GIY02_22255 ENOG4105EHG Permease protein GIY02_22275 ENOG4105CDV Ompa motb domain protein GIY02_22365 ENOG4108I1J Integrase GIY02_22375 ENOG41076J9 exonuclease VIII GIY02_22465 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GIY02_22470 ENOG4108MXB Protein of unknown function (DUF968) GIY02_22575 ENOG4105TKZ Tail Sheath GIY02_22630 ENOG4105MEV Acyl-transferase GIY02_22670 ENOG4105KT5 UmuD protein GIY02_22675 ENOG4105CS6 Rhs element vgr protein GIY02_22690 ENOG4105CNA YD repeat protein GIY02_22740 ENOG4105BZU Histidine kinase GIY02_22755 ENOG4106TD9 Diguanylate cyclase GIY02_22760 ENOG4105DHT Metal Dependent Phosphohydrolase GIY02_22765 ENOG4105D1S lipid A biosynthesis GIY02_22770 ENOG4108NIW Leucine export protein LeuE GIY02_22775 ENOG4105S5I Membrane GIY02_22790 ENOG4106G4W GIY02_22795 ENOG410620I Diguanylate cyclase GIY02_22800 ENOG4105UCG Domain of unknown function (DUF333) GIY02_22805 ENOG4105K78 MarR family Transcriptional regulator GIY02_22810 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GIY02_22815 ENOG4105DJ2 Major Facilitator Superfamily GIY02_22820 ENOG4105R1U AraC Family Transcriptional Regulator GIY02_22825 ENOG4108VMM UPF0756 membrane protein GIY02_22830 ENOG4108KXH Ybak prolyl-tRNA synthetase associated GIY02_22835 ENOG4108KHP Diguanylate cyclase GIY02_22850 ENOG4105CYN Serine protein kinase GIY02_22855 ENOG4105GNX MltA-interacting MipA family protein GIY02_22860 ENOG4105DSB aldose 1-epimerase GIY02_22865 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GIY02_22875 ENOG4105VUT cytoplasmic protein GIY02_22885 ENOG4108RWI nicotinamidase GIY02_22890 ENOG4105HDK L-asparaginase GIY02_22895 ENOG4105D07 Signal peptide peptidase, SppA GIY02_22900 ENOG41069NU Nitroreductase GIY02_22905 ENOG4105SBG acid phosphatase GIY02_22910 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) GIY02_22915 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GIY02_22930 ENOG4105D82 Glutamate dehydrogenase GIY02_22935 ENOG4105M6F mutator MutT protein GIY02_22940 ENOG4108T9J Cdp-alcohol phosphatidyltransferase GIY02_22950 ENOG4108VGW abc transporter atp-binding protein GIY02_22955 ENOG4105CXZ ABC transporter, permease GIY02_22960 ENOG4105VNH ABC transporter solute-binding protein GIY02_22965 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GIY02_22970 ENOG4108N5C SNARE associated Golgi protein-related protein GIY02_22975 ENOG4108RSN SNARE associated Golgi GIY02_22980 ENOG4105CGK Exodeoxyribonuclease III GIY02_22990 ENOG4105F4X arginine GIY02_22995 ENOG4105C26 Dehydrogenase GIY02_23000 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) GIY02_23010 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) GIY02_23020 ENOG4105KKI DNA-binding transcriptional activator OsmE GIY02_23025 ENOG4105VZJ PTS System GIY02_23030 ENOG4105CK1 PTS System GIY02_23035 ENOG4105VCP PTS System GIY02_23040 ENOG4105EZV Transcriptional regulator GIY02_23045 ENOG4105F8D glycoside hydrolase family 4 GIY02_23050 ENOG410901P UPF0249 protein GIY02_23055 ENOG4105CH6 catalase GIY02_23060 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) GIY02_23065 ENOG4108ETY sodium dicarboxylate symporter GIY02_23070 ENOG4107K5X Membrane-bound metal-dependent hydrolase GIY02_23075 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 GIY02_23080 ENOG4107PN8 YfeABCD locus regulator GIY02_23085 ENOG4105NAU thioesterase Superfamily protein GIY02_23090 ENOG4107835 probably involved in intracellular septation (By similarity) GIY02_23100 ENOG4105PI0 Ferredoxin GIY02_23105 ENOG4105EIF outer membrane protein W GIY02_23110 ENOG4108Q2M Transcriptional regulator GIY02_23120 ENOG4105KK7 inner membrane protein YiaW GIY02_23125 ENOG4105EFX secretion protein, HlyD family GIY02_23130 ENOG4105CPQ Dehydrogenase GIY02_23150 ENOG4105DK0 Indole-3-glycerol phosphate synthase GIY02_23155 ENOG4108EFP Anthranilate synthase component II GIY02_23160 ENOG4105CRQ synthase (Component I) GIY02_23165 ENOG4105DB7 PHP domain protein GIY02_23170 ENOG4107RTD sua5 ycio yrdc ywlc family protein GIY02_23185 ENOG4105FE9 pseudouridine synthase GIY02_23190 ENOG4105CT4 transporter GIY02_23195 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GIY02_23200 ENOG41075H3 AraC family transcriptional regulator GIY02_23205 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GIY02_23210 ENOG4105UBK short-chain dehydrogenase reductase GIY02_23215 ENOG4105ERU peptidase GIY02_23220 ENOG4105RKX Protein of unknown function (DUF2498) GIY02_23225 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GIY02_23230 ENOG4107R11 Transcriptional regulator GIY02_23240 ENOG4107QM5 aconitate hydratase GIY02_23250 ENOG4105EYK Phosphatidylglycerophosphatase B GIY02_23255 ENOG4105Q4A inner membrane protein yciS GIY02_23260 ENOG4105CFV Tetratricopeptide repeat protein GIY02_23270 ENOG4108ZJT translation initiation factor, Sui1 GIY02_23275 ENOG41061RM osmotically inducible lipoprotein GIY02_23280 ENOG4105N2W Transcriptional regulator GIY02_23290 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) GIY02_23295 ENOG4105Q4T oxidoreductase GIY02_23300 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GIY02_23310 ENOG4105ETS cytosine purines uracil thiamine allantoin GIY02_23315 ENOG4108JQ2 peptide transport system atp-binding protein GIY02_23320 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein GIY02_23325 ENOG4108EU3 peptide transport system, permease GIY02_23330 ENOG4108I5W peptide transport system, permease protein GIY02_23335 ENOG4108J59 Extracellular solute-binding protein, family 5 GIY02_23350 ENOG4105CH2 amidohydrolase GIY02_23360 ENOG4105E51 psp operon transcriptional activator GIY02_23365 ENOG41087YS Phage shock protein A GIY02_23370 ENOG4105YYT phage shock protein B GIY02_23375 ENOG4105FM1 phage shock protein C GIY02_23380 ENOG4105NNG Peripheral inner membrane phage-shock protein GIY02_23385 ENOG4105CM6 amino acid regulated cytosolic protein GIY02_23400 ENOG4108KK1 membrane protein AbrB duplication GIY02_23405 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GIY02_23410 ENOG4107S8C mandelate racemase muconate lactonizing GIY02_23415 ENOG4105KXI murein peptide amidase A GIY02_23420 ENOG4107QSI ABC, transporter GIY02_23425 ENOG4105ETE Transcriptional regulator (LacI family GIY02_23430 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia GIY02_23440 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GIY02_23445 ENOG4105UP7 3-epimerase GIY02_23455 ENOG4108YRF PTS System GIY02_23460 ENOG4105DM4 PTS System GIY02_23465 ENOG4105CV8 reductase GIY02_23495 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GIY02_23515 ENOG4107R7Y intracellular protease Pfpi family GIY02_23525 ENOG4105D9R oxidoreductase GIY02_23530 ENOG4105E98 transcriptional regulator DeoR family GIY02_23535 ENOG4108JQ6 ABC transporter GIY02_23545 ENOG4108NZE NAGC-like transcriptional regulator GIY02_23560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GIY02_23565 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) GIY02_23570 ENOG4105KD7 acetyltransferase GIY02_23575 ENOG4107RX3 Mg2 transporter protein cora family protein GIY02_23580 ENOG4105C1J atp-dependent rna helicase GIY02_23590 ENOG4108RW8 Universal stress protein F GIY02_23595 ENOG4105FCK Membrane GIY02_23610 ENOG41090X5 Heat shock protein hslJ GIY02_23615 ENOG4105C5I Dehydrogenase GIY02_23620 ENOG4108KF1 Membrane GIY02_23625 ENOG4107H52 Dicarboxylate transport GIY02_23630 ENOG410689M (LipO)protein GIY02_23635 ENOG4105WXT Conserved Protein GIY02_23640 ENOG4108WFR AraC Family Transcriptional Regulator GIY02_23645 ENOG4105C26 Dehydrogenase GIY02_23660 ENOG4105DXM phenylacetic acid degradation protein GIY02_23665 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GIY02_23670 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit GIY02_23675 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GIY02_23680 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GIY02_23685 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GIY02_23690 ENOG4105E39 Enoyl-CoA hydratase GIY02_23695 ENOG4108UKI Enoyl-CoA hydratase GIY02_23705 ENOG4108ZJI phenylacetic acid degradation protein GIY02_23710 ENOG4105CHU acetyl-coa acetyltransferase GIY02_23715 ENOG4105DZS Phenylacetate-CoA ligase GIY02_23720 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein GIY02_23725 ENOG4108Z0R Transferase GIY02_23735 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GIY02_23740 ENOG4105CQ7 ATP-dependent helicase GIY02_23750 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GIY02_23770 ENOG4105D82 Glutamate dehydrogenase GIY02_23775 ENOG4105C8Y Acetylornithine aminotransferase GIY02_23780 ENOG4105F4X arginine GIY02_23785 ENOG4105C26 Dehydrogenase GIY02_23790 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) GIY02_23795 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) GIY02_23805 ENOG4107DB1 DUF218 domain GIY02_23810 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GIY02_23830 ENOG4108MBX Secretion Protein GIY02_23835 ENOG4108JJA ABC, transporter GIY02_23845 ENOG4105CPW cytochrome b561 GIY02_23885 ENOG4105DDW LysR family Transcriptional regulator GIY02_23890 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha GIY02_23895 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta GIY02_23900 ENOG4105E32 cytoplasmic protein GIY02_23905 ENOG4105EBR Carboxylesterase GIY02_23910 ENOG4105ETT transcriptional Regulator, LysR family GIY02_23915 ENOG4105CHJ isochorismatase hydrolase GIY02_23920 ENOG4108ETY sodium dicarboxylate symporter GIY02_23925 ENOG4105CHM Aminotransferase GIY02_23930 ENOG4105E89 ABC transporter GIY02_23950 ENOG4108Z9I -acetyltransferase GIY02_23955 ENOG4107WE3 acetyltransferase YdcK GIY02_23960 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein GIY02_23965 ENOG41088CC tellurite resistance protein tehB GIY02_23970 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GIY02_23975 ENOG4105DEF Extracellular solute-binding protein, family 5 GIY02_23980 ENOG4108KKZ (LipO)protein GIY02_23985 ENOG4105DWP Membrane GIY02_23990 ENOG4105UEI Transcriptional Regulator AraC Family GIY02_23995 ENOG4105DKK Benzoate GIY02_24000 ENOG4108JCI Transcriptional regulator GIY02_24005 ENOG4105CFP Peptidase U32 GIY02_24020 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GIY02_24025 ENOG4105C4M (Ubiquinol oxidase) subunit I GIY02_24030 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GIY02_24035 ENOG4107TYH extracellular solute-binding protein family 1 GIY02_24040 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GIY02_24045 ENOG4105D81 ABC transporter, permease GIY02_24050 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component GIY02_24055 ENOG4105C26 Dehydrogenase GIY02_24075 ENOG410654E Membrane GIY02_24080 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GIY02_24090 ENOG4105DEF Extracellular solute-binding protein, family 5 GIY02_24095 ENOG4105R71 cytoplasmic protein GIY02_24100 ENOG4108T9Y Inner membrane protein ydcZ GIY02_24105 ENOG4108Z7F N-acetyltransferase GIY02_24115 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GIY02_24120 ENOG41065TG regulatoR GIY02_24125 ENOG4105CHB tonB-dependent Receptor GIY02_24130 ENOG4108NS2 receptor GIY02_24140 ENOG4105C85 amino acid GIY02_24145 ENOG4105EQ2 LysR family Transcriptional regulator GIY02_24155 ENOG4105DEN Luciferase family GIY02_24160 ENOG4105CH2 amidohydrolase GIY02_24170 ENOG4105EAB amino acid AbC transporter GIY02_24185 ENOG4105CDA abc transporter atp-binding protein GIY02_24190 ENOG4105EAB amino acid AbC transporter GIY02_24200 ENOG4108N27 Glutathione S-transferase GIY02_24225 ENOG4108MEJ flavin reductase domain protein GIY02_24230 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GIY02_24235 ENOG4105D0D Nitrate reductase 2, gamma subunit GIY02_24240 ENOG4108NZN Respiratory nitrate reductase 2 delta chain GIY02_24245 ENOG4108IUE nitrate reductase beta subunit GIY02_24250 ENOG4105CRU nitrate reductase, alpha subunit GIY02_24255 ENOG4107QND Nitrite extrusion protein GIY02_24270 ENOG4107HP6 Transcriptional regulator GIY02_24275 ENOG4105DTQ mandelate racemase muconate lactonizing GIY02_24280 ENOG4105NN7 muconolactone delta-isomerase GIY02_24285 ENOG410626B catechol 1,2-dioxygenase GIY02_24295 ENOG4108UKV benzoate 1,2-dioxygenase GIY02_24310 ENOG4105RPH Inner membrane protein YddG GIY02_24320 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GIY02_24325 ENOG4108MG3 formate dehydrogenase GIY02_24345 ENOG4105N0V mono-oxygenase ydhR GIY02_24365 ENOG4105C32 Amino acid ABC transporter (Permease) GIY02_24370 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GIY02_24375 ENOG4105C0Z ABC transporter GIY02_24380 ENOG4108IV0 ABC, transporter GIY02_24385 ENOG4105F27 Major Facilitator GIY02_24405 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GIY02_24415 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GIY02_24420 ENOG4105DQ4 alcohol dehydrogenase GIY02_24430 ENOG4105C5H ABC transporter GIY02_24450 ENOG4105ETE Transcriptional regulator (LacI family GIY02_24470 ENOG4105EQ2 LysR family Transcriptional regulator GIY02_24475 ENOG4108Z9K Osmotically inducible protein GIY02_24490 ENOG4105EZR dyp-type peroxidase family protein GIY02_24495 ENOG4105FFC UPF0187 protein GIY02_24505 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GIY02_24510 ENOG4105C4M (Ubiquinol oxidase) subunit I GIY02_24515 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit GIY02_24520 ENOG4105C5Q Transcriptional regulator GIY02_24525 ENOG4105CR8 Transcriptional regulator GIY02_24535 ENOG4107TE1 transport protein GIY02_24545 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GIY02_24560 ENOG4105U5Y Transcriptional regulator GIY02_24565 ENOG4105D6Z AFG1 family ATPase GIY02_24570 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GIY02_24575 ENOG4106KR7 LysR family Transcriptional regulator GIY02_24600 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF GIY02_24620 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) GIY02_24630 ENOG4108IGT Dipeptidase GIY02_24640 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GIY02_24645 ENOG4105E0F Histidine kinase GIY02_24655 ENOG4105DY8 decarboxylase GIY02_24660 ENOG4108JPW Aminotransferase GIY02_24665 ENOG4107Z6I Thiamine biosynthesis protein GIY02_24670 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component GIY02_24675 ENOG4108YI8 ABC transporter GIY02_24680 ENOG4105ETU transcriptional activator (TenA GIY02_24715 ENOG4105HEI LysR family (Transcriptional regulator GIY02_24725 ENOG4105F32 YngK protein GIY02_24730 ENOG4109076 Conserved Protein GIY02_24750 ENOG4106VK6 Flagellar motor protein GIY02_24795 ENOG4108WC9 type VI secretion system effector, hcp1 family GIY02_24835 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GIY02_24850 ENOG4105CS6 Rhs element vgr protein GIY02_24925 ENOG4108WN0 inhibitor of vertebrate lysozyme GIY02_24930 ENOG4105CUY Mechanosensitive ion channel GIY02_24935 ENOG4108SZE gCN5-related N-acetyltransferase GIY02_24965 ENOG41061H0 Monooxygenase GIY02_24970 ENOG4105C2W permease GIY02_24980 ENOG41084YZ Hydrolase GIY02_24985 ENOG4107QUY Guanine deaminase GIY02_24990 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GIY02_25000 ENOG410633P Hydantoin racemase GIY02_25025 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GIY02_25040 ENOG4105DRP amino acid AbC transporter GIY02_25045 ENOG4105E5Q amino acid AbC transporter GIY02_25055 ENOG4105C5R Aminotransferase GIY02_25065 ENOG4105C0R drug resistance transporter emrb qaca subfamily GIY02_25115 ENOG4105BZS acriflavin resistance protein GIY02_25140 ENOG4105CPC Aldo Keto reductase GIY02_25145 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF GIY02_25155 ENOG4105CV8 reductase GIY02_25170 ENOG4105JQN Transcriptional regulator GIY02_25175 ENOG4105EQ2 LysR family Transcriptional regulator GIY02_25180 ENOG4105CPC Aldo Keto reductase GIY02_25185 ENOG4107SET aldo keto reductase GIY02_25190 ENOG4105CPC Aldo Keto reductase GIY02_25200 ENOG41060NJ transcriptional regulator GIY02_25205 ENOG4105DKQ ROK family GIY02_25210 ENOG4105VCP PTS System GIY02_25215 ENOG4105CK1 PTS System GIY02_25220 ENOG4105VZJ PTS System GIY02_25225 ENOG4105CK1 PTS System GIY02_25230 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GIY02_25240 ENOG4105CS2 ec 3.2.1.21 GIY02_25250 ENOG4105GVR general secretion pathway protein D GIY02_25250 ENOG4105GVR general secretion pathway protein D GIY02_25305 ENOG4105GVR general secretion pathway protein D GIY02_25305 ENOG4105GVR general secretion pathway protein D GIY02_25360 ENOG4105GVR general secretion pathway protein D GIY02_25360 ENOG4105GVR general secretion pathway protein D