locus-tag class description FR848_00005 ENOG4105EAM Na Pi-cotransporter FR848_00010 ENOG4105C3R Methionine synthase FR848_00015 ENOG41069M3 Transcriptional regulator FR848_00030 ENOG4108I9X Isocitrate lyase FR848_00035 ENOG4107QP3 malate synthase g FR848_00040 ENOG4105CVG Homoserine O-transsuccinylase FR848_00045 ENOG4105K5X acetyltransferase FR848_00070 ENOG4105DC1 bifunctional purine biosynthesis protein purh FR848_00075 ENOG4105C12 Phosphoribosylglycinamide synthetase FR848_00085 ENOG4105BZU Histidine kinase FR848_00095 ENOG4108T8B Protein of unknown function (DUF1481) FR848_00100 ENOG4105K70 DNA-binding protein FR848_00105 ENOG4105R2J Conserved Protein FR848_00120 ENOG4105E09 nadh pyrophosphatase FR848_00125 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) FR848_00130 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FR848_00135 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FR848_00140 ENOG4105D06 uba thif-type nad fad binding protein FR848_00145 ENOG4105WHD thiamine biosynthesis protein ThiS FR848_00155 ENOG4105D41 biosynthesis protein thiH FR848_00160 ENOG4106TD9 Diguanylate cyclase FR848_00170 ENOG4105VCP PTS System FR848_00175 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FR848_00180 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FR848_00185 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FR848_00190 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FR848_00195 ENOG4108VZM 50s ribosomal protein L10 FR848_00210 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FR848_00215 ENOG4105PM1 preprotein translocase subunit SecE FR848_00220 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FR848_00255 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FR848_00260 ENOG4105D4A Cell wall formation (By similarity) FR848_00290 ENOG4108RR8 protoporphyrinogen oxidase FR848_00295 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FR848_00300 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FR848_00305 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) FR848_00315 ENOG4105CHU acetyl-coa acetyltransferase FR848_00325 ENOG4107QK7 reductase FR848_00330 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FR848_00335 ENOG4105MDZ Transcriptional activator rfaH FR848_00345 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FR848_00355 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FR848_00360 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FR848_00365 ENOG4105JC1 sterol-binding domain protein FR848_00370 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FR848_00375 ENOG4105CGY Dna recombination protein FR848_00380 ENOG4108I5U Uridine phosphorylase FR848_00385 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FR848_00395 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FR848_00400 ENOG4105DZ2 Transcriptional regulator FR848_00405 ENOG4105EMK carboxylate amino acid amine transporter FR848_00410 ENOG4105DQF Hydrolase FR848_00415 ENOG4108EUD Lysophospholipase FR848_00420 ENOG410829K Lysine exporter protein (Lyse ygga) FR848_00430 ENOG4105CCF Lysine exporter protein (Lyse ygga) FR848_00435 ENOG4105C9U ATP-dependent DNA helicase RecQ FR848_00440 ENOG4105HDD phospholipase FR848_00445 ENOG4108VUY thioesterase Superfamily protein FR848_00450 ENOG4105FR1 rard protein FR848_00455 ENOG4107QUT magnesium and cobalt transport protein CorA FR848_00460 ENOG4105C4R Atp-dependent dna helicase FR848_00465 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant FR848_00470 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FR848_00475 ENOG4105CT0 Protein of unknown function, DUF484 FR848_00485 ENOG4105S7Z (LipO)protein FR848_00495 ENOG4105CI2 imidazolone-5-propionate hydrolase FR848_00510 ENOG4105XQ6 frataxin-like protein FR848_00515 ENOG4107T0K Adenylate cyclase FR848_00525 ENOG41076E6 Uroporphyrinogen-III Synthase FR848_00530 ENOG4105ECF c-methyltransferase FR848_00535 ENOG410601J HemY protein FR848_00560 ENOG4105C85 amino acid FR848_00570 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) FR848_00575 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) FR848_00580 ENOG4105EGZ biosynthesis protein FR848_00585 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FR848_00590 ENOG4108WJ1 acetyltransferase FR848_00595 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FR848_00600 ENOG4105C1B dTDP-glucose 4-6-dehydratase FR848_00605 ENOG4108IJ1 Dehydrogenase FR848_00610 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FR848_00615 ENOG4105SFE lipopolysaccharide biosynthesis protein FR848_00620 ENOG4105ESV Glycosyl transferase, family 4 FR848_00630 ENOG4105K63 Thioredoxin FR848_00635 ENOG4105C1J atp-dependent rna helicase FR848_00650 ENOG4108KD5 ADP-ribosylation crystallin J1 FR848_00665 ENOG4105C4R Atp-dependent dna helicase FR848_00670 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FR848_00675 ENOG4108I5U Uridine phosphorylase FR848_00685 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FR848_00690 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FR848_00700 ENOG4105EMY transcriptional regulator FR848_00705 ENOG4105C7B Threonine dehydratase FR848_00715 ENOG4105CM2 brancheD-chain amino acid aminotransferase FR848_00720 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit FR848_00735 ENOG4105C0P Mg chelatase subunit ChlI FR848_00740 ENOG4108WFC UPF0438 protein yifE FR848_00800 ENOG4108Y73 Membrane FR848_00805 ENOG4105EJ2 Transcriptional regulator FR848_00810 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FR848_00815 ENOG4105C5Q Transcriptional regulator FR848_00830 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FR848_00845 ENOG4108MEK Metal-binding protein YodA FR848_00850 ENOG4106R3P AraC family transcriptional regulator FR848_00860 ENOG4105DCT glycerol dehydrogenase FR848_00865 ENOG4105E98 transcriptional regulator DeoR family FR848_00870 ENOG4105SYT Methylenetetrahydrofolate reductase FR848_00875 ENOG4108KB2 LysR family Transcriptional regulator FR848_00880 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FR848_00885 ENOG4105CFH Aspartokinase FR848_00890 ENOG4105C28 cystathionine FR848_00900 ENOG4108RS6 transposase FR848_00910 ENOG4105C25 Primosomal protein n' FR848_00915 ENOG4105ETE Transcriptional regulator (LacI family FR848_00920 ENOG41063M6 Cell Division Protein FR848_00935 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FR848_00950 ENOG41076HS cation diffusion facilitator family transporter FR848_00955 ENOG4105FMW periplasmic FR848_00960 ENOG4105E3W Two component transcriptional regulator (Winged helix family FR848_00965 ENOG4105E0F Histidine kinase FR848_00970 ENOG4108RPX mosc domain containing protein FR848_00975 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FR848_00985 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) FR848_00990 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) FR848_01000 ENOG4105DET Rhamnulokinase FR848_01010 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) FR848_01015 ENOG4105D4B ABC, transporter FR848_01020 ENOG4105C2J ABC transporter FR848_01025 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FR848_01030 ENOG4105F5R ABC transporter FR848_01035 ENOG4105C0A alcohol dehydrogenase FR848_01055 ENOG4108HKT sucrose-6-phosphate hydrolase FR848_01060 ENOG4105CT4 transporter FR848_01065 ENOG4105ETE Transcriptional regulator (LacI family FR848_01080 ENOG4105D64 Mechanosensitive ion channel FR848_01095 ENOG4106PH7 chaperone FR848_01105 ENOG4105Q7J Fimbrial FR848_01110 ENOG4105MHR Fimbrial protein FR848_01115 ENOG4105CW0 outer membrane usher protein FR848_01120 ENOG4108NAE Fimbrial chaperone protein FR848_01125 ENOG4108RQP Major type 1 subunit fimbrin FR848_01130 ENOG4108RQP Major type 1 subunit fimbrin FR848_01145 ENOG4108UW5 maltose o-acetyltransferase FR848_01150 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FR848_01195 ENOG4108UMN azlc family FR848_01220 ENOG4105D2N Aldolase FR848_01235 ENOG4105CTQ phosphohexokinase FR848_01250 ENOG4105EP8 Glycosyl Hydrolase Family 88 FR848_01260 ENOG4105ETZ PTS System FR848_01275 ENOG4105E4I Glycoside hydrolase family 28 FR848_01295 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FR848_01300 ENOG4108MG3 formate dehydrogenase FR848_01305 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) FR848_01315 ENOG4105SUU thioesterase domain FR848_01320 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FR848_01325 ENOG4107S2Z UPF0761 membrane protein FR848_01330 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 FR848_01340 ENOG4105C5F glutamine synthetase FR848_01345 ENOG4105CUX Signal transduction histidine kinase FR848_01350 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FR848_01355 ENOG4106FIY FR848_01360 ENOG4105D4P Coproporphyrinogen iii oxidase FR848_01370 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) FR848_01385 ENOG4105C2M dna polymerase I FR848_01390 ENOG4106HNH Acyl-transferase FR848_01400 ENOG4105E27 serine threonine protein kinase FR848_01405 ENOG4105PC1 Conserved Protein FR848_01410 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FR848_01415 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b FR848_01435 ENOG4107EJG GntR family transcriptional regulator FR848_01440 ENOG4105C0R drug resistance transporter emrb qaca subfamily FR848_01445 ENOG4105ETE Transcriptional regulator (LacI family FR848_01450 ENOG4108RVA ribokinase FR848_01455 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FR848_01460 ENOG4105CNN ABC, transporter FR848_01465 ENOG4105C2J ABC transporter FR848_01475 ENOG4105DFH Transport of potassium into the cell (By similarity) FR848_01490 ENOG4105CU9 asparagine synthetase A FR848_01495 ENOG4108VVK transcriptional Regulator, AsnC FR848_01500 ENOG4105QTB Flavodoxin FR848_01505 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FR848_01515 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation FR848_01525 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FR848_01540 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FR848_01550 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FR848_01555 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FR848_01565 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FR848_01570 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FR848_01580 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FR848_01585 ENOG4105C8U phosphate abc transporter FR848_01590 ENOG4105E2Z phosphate ABC transporter (Permease FR848_01595 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FR848_01605 ENOG4108P68 Outer membrane porin FR848_01610 ENOG4105DYC esterase FR848_01615 ENOG4107VKM 6-phosphogluconolactonase FR848_01620 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 FR848_01630 ENOG4105C7N Xanthine uracil vitamin C permease FR848_01635 ENOG4108YYH Nadph-dependent fmn reductase FR848_01640 ENOG4105E8Q phosphopantetheinyl transferase FR848_01655 ENOG41080E2 ribosomal-protein-alanine acetyltransferase FR848_01665 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FR848_01670 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FR848_01680 ENOG4105VG0 50S ribosomal protein l34 FR848_01690 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FR848_01700 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FR848_01705 ENOG4105CC0 LysR family Transcriptional regulator FR848_01710 ENOG4105DQ4 alcohol dehydrogenase FR848_01715 ENOG410667J hydrolase FR848_01720 ENOG4105EMF GntR family transcriptional regulator FR848_01725 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 FR848_01730 ENOG4108RTU Aldolase FR848_01735 ENOG4105CXK mandelate racemase muconate lactonizing FR848_01740 ENOG4105DJB Major Facilitator Superfamily FR848_01745 ENOG4105D99 atp gtp-binding protein FR848_01750 ENOG4105R2A (LipO)protein FR848_01765 ENOG4105D0C transport protein FR848_01770 ENOG4105FDP GntR family transcriptional regulator FR848_01775 ENOG4105CI1 PTS System FR848_01780 ENOG4105F8D glycoside hydrolase family 4 FR848_01785 ENOG4105VG5 Membrane FR848_01790 ENOG4105JP4 Inner membrane protein yidG FR848_01795 ENOG4105J13 transcriptional regulator FR848_01800 ENOG4105BZC d-serine deaminase FR848_01810 ENOG4105W8I Transcriptional regulator FR848_01815 ENOG4105E5M Multidrug resistance protein D FR848_01840 ENOG4105C7K acetolactate synthase FR848_01845 ENOG4105M71 acetolactate synthase 1 regulatory subunit FR848_01850 ENOG4108KX4 response regulator FR848_01855 ENOG4105BZU Histidine kinase FR848_01860 ENOG4105CXY transporter FR848_01865 ENOG4105CXY transporter FR848_01875 ENOG4108SAJ Protein of unknown function (DUF1198) FR848_01895 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FR848_01900 ENOG4107STF Involved in phosphonate degradation (By similarity) FR848_01905 ENOG4106S9K Transcriptional regulator FR848_01910 ENOG4105CY5 solute-binding protein FR848_01920 ENOG4108MP3 ABC transporter, permease FR848_01930 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FR848_01935 ENOG4105VCP PTS System FR848_01950 ENOG4105DDV Transcriptional regulator (LacI family FR848_01960 ENOG4105DNE Transposase FR848_01970 ENOG4108UZ3 Transporter FR848_01985 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) FR848_01990 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FR848_01995 ENOG4105C2C drug resistance transporter, Bcr CflA FR848_02000 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FR848_02005 ENOG4105BZS acriflavin resistance protein FR848_02010 ENOG4105C1P efflux transporter, rnd family, mfp subunit FR848_02020 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FR848_02030 ENOG4105CR8 Transcriptional regulator FR848_02045 ENOG4105D01 (LipO)protein FR848_02060 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein FR848_02070 ENOG4105DQ4 alcohol dehydrogenase FR848_02085 ENOG4105NI3 Protein of unknown function (DUF3237) FR848_02090 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FR848_02120 ENOG4105CT4 transporter FR848_02125 ENOG4105CJQ hydrolase, family 31 FR848_02130 ENOG4105ETD TRANSCRIPTIONal FR848_02135 ENOG4105DM4 PTS System FR848_02140 ENOG4108YRF PTS System FR848_02145 ENOG4105DM4 PTS System FR848_02150 ENOG4105D2N Aldolase FR848_02155 ENOG4105D2N Aldolase FR848_02160 ENOG4105DKQ ROK family FR848_02175 ENOG4105F8D glycoside hydrolase family 4 FR848_02180 ENOG4105CI1 PTS System FR848_02185 ENOG4105JV1 AsmA family FR848_02190 ENOG4105C2W permease FR848_02195 ENOG4105D6U Sodium Glutamate Symporter FR848_02205 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FR848_02210 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) FR848_02215 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FR848_02230 ENOG4105CP7 Triose-phosphate isomerase FR848_02235 ENOG4105EBK exported protein FR848_02240 ENOG4108VTS Membrane FR848_02245 ENOG4105DP0 ferredoxin-NADP reductase FR848_02250 ENOG4105CBT Fructose-1,6-bisphosphatase FR848_02255 ENOG4105CB5 ATP-dependent DNA helicase recG FR848_02260 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FR848_02265 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FR848_02270 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FR848_02275 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FR848_02290 ENOG4105EN6 Membrane FR848_02300 ENOG4105DSJ YicC domain protein FR848_02310 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FR848_02325 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FR848_02330 ENOG4105W5Q DNA repair protein (RadC FR848_02335 ENOG4105KDC 50s ribosomal protein l28 FR848_02340 ENOG4105W0E 50S ribosomal protein L33 FR848_02355 ENOG4106WTF Glycosyl transferase, family 2 FR848_02360 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FR848_02365 ENOG4105K64 Glycosyl transferase, family 2 FR848_02370 ENOG4105CPK Glycosyl transferase (Group 1 FR848_02380 ENOG4105DKP glycosyl transferase, family 9 FR848_02405 ENOG4105D16 lipopolysaccharide heptosyltransferase i FR848_02410 ENOG4105XA0 heptosyltransferase ii FR848_02415 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FR848_02420 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FR848_02425 ENOG4105CPQ Dehydrogenase FR848_02430 ENOG4106WTF Glycosyl transferase, family 2 FR848_02435 ENOG4105PXI polysaccharide deacetylase FR848_02440 ENOG41063SB peptidase FR848_02450 ENOG4107YZP Rhodanese domain protein FR848_02455 ENOG4105VW4 glutaredoxin 3 FR848_02470 ENOG4105D7W serine acetyltransferase FR848_02475 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FR848_02485 ENOG41073TP transcriptional regulator FR848_02490 ENOG4105DAA L-lactate FR848_02495 ENOG4108YYI Protein of unknown function (DUF2810) FR848_02505 ENOG4105E61 Mannitol repressor protein FR848_02515 ENOG4105CTS PTS system mannitol-specific FR848_02520 ENOG4105KK7 inner membrane protein YiaW FR848_02525 ENOG4105EFX secretion protein, HlyD family FR848_02530 ENOG4108U78 Glutathione S-transferase FR848_02535 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) FR848_02540 ENOG4105EM7 Selenocysteine-specific translation elongation factor FR848_02550 ENOG4105CT4 transporter FR848_02555 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) FR848_02560 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FR848_02565 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase FR848_02570 ENOG4105H6Q decarboxylase FR848_02575 ENOG4105CMG Carbohydrate kinase FR848_02585 ENOG4108M5W FR848_02590 ENOG4108R66 Conserved Protein FR848_02605 ENOG4105J4Q Transcriptional regulator FR848_02610 ENOG4108RC0 Electron transport protein FR848_02615 ENOG4105JKW Valine--pyruvate aminotransferase FR848_02620 ENOG4107T9C Alpha amylase catalytic region FR848_02625 ENOG4108UR8 BAX protein FR848_02630 ENOG4105T16 Transcriptional regulator (AraC family) FR848_02635 ENOG4107RNG ABC transporter FR848_02640 ENOG4105C2J ABC transporter FR848_02645 ENOG4105DFW ABC transporter FR848_02650 ENOG4105C93 Xylose Isomerase FR848_02655 ENOG4105CMG Carbohydrate kinase FR848_02660 ENOG410688U Inner membrane protein yiaB FR848_02665 ENOG4105MEV Acyl-transferase FR848_02680 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FR848_02695 ENOG41060TC Hok gef cell toxic protein FR848_02705 ENOG4105VEQ Cold shock protein FR848_02710 ENOG4105MVF Transcriptional regulator FR848_02715 ENOG4105D2S major facilitator superfamily FR848_02720 ENOG4106JH6 (LipO)protein FR848_02725 ENOG4105C5I Dehydrogenase FR848_02735 ENOG4105D7K pfkb domain protein FR848_02745 ENOG4108M60 Transcriptional regulator FR848_02750 ENOG4108ZG0 Ompa motb domain protein FR848_02760 ENOG4107QY8 reductase FR848_02765 ENOG4105HNP -acetyltransferase FR848_02770 ENOG4108R3E Dna-3-methyladenine glycosylase i FR848_02775 ENOG4105EAX Putative lipase FR848_02780 ENOG4105FCD Major Facilitator FR848_02785 ENOG4105DIJ Phosphoethanolamine transferase FR848_02800 ENOG4105DEF Extracellular solute-binding protein, family 5 FR848_02805 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FR848_02810 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FR848_02815 ENOG4105C3U ABC transporter FR848_02820 ENOG4108JQ7 (ABC) transporter FR848_02840 ENOG4107EEX Cellulose synthase regulator protein FR848_02845 ENOG4105EJG cellulose synthase FR848_02875 ENOG4105D1V cellulose synthase operon protein YhjU FR848_02880 ENOG4105WQA Cellulose biosynthesis protein BcsF FR848_02885 ENOG4105U74 cellulose biosynthesis protein BcsE FR848_02890 ENOG410661M cytoplasmic protein FR848_02895 ENOG4105UTS cellulose synthase operon protein YhjQ FR848_02900 ENOG4107QZ7 Cellulose synthase catalytic subunit FR848_02905 ENOG4105D7V transposase FR848_02910 ENOG4107EEX Cellulose synthase regulator protein FR848_02915 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FR848_02920 ENOG4105EJG cellulose synthase FR848_02930 ENOG4105BZU Histidine kinase FR848_02940 ENOG4105CS0 peptidase FR848_02955 ENOG41066T0 asmA family FR848_02960 ENOG4105CSH Transporter FR848_02965 ENOG4107H3J ribonuclease FR848_02970 ENOG4105CBN LysR family transcriptional regulator FR848_02975 ENOG4105CHR reductase FR848_02980 ENOG4106S2D Transcriptional regulator FR848_03000 ENOG4105C0A alcohol dehydrogenase FR848_03005 ENOG4108TGY Glutathione S-transferase FR848_03010 ENOG4105DC8 reductase FR848_03015 ENOG4105D6S protein involved in catabolism of external DNA FR848_03020 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FR848_03025 ENOG4105E0F Histidine kinase FR848_03030 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FR848_03035 ENOG4108RRZ Transcription elongation factor GreB FR848_03040 ENOG4105BZM domain protein FR848_03045 ENOG4105XFK Ferrous iron transport protein A FR848_03050 ENOG4105CE1 Ferrous iron transport protein b FR848_03055 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) FR848_03070 ENOG4105MJ2 Competence protein FR848_03080 ENOG4105C6Z Gluconate FR848_03085 ENOG4105DGW oligopeptidase A FR848_03090 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) FR848_03095 ENOG4105DUX Transporter FR848_03100 ENOG4108M6U Universal stress protein A FR848_03110 ENOG4105CJ3 phosphate transporter FR848_03115 ENOG4105CBX hi0933 family FR848_03120 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FR848_03125 ENOG41069H0 dihydroorotase EC 3.5.2.3 FR848_03130 ENOG4107QPK )-transporter FR848_03135 ENOG4105JSC dimethylmenaquinone methyltransferase FR848_03150 ENOG4105CJW magnesium transporter FR848_03160 ENOG4105MRR Transcriptional regulator (By similarity) FR848_03165 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) FR848_03170 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) FR848_03175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FR848_03180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FR848_03185 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FR848_03200 ENOG4105PY6 Phenolic acid decarboxylase FR848_03215 ENOG4105C3I Nad-dependent epimerase dehydratase FR848_03220 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FR848_03240 ENOG4105DSF transport protein FR848_03245 ENOG4105F9N Major Facilitator Superfamily FR848_03250 ENOG4108W1V Lipoprotein FR848_03255 ENOG4105EX9 Membrane FR848_03270 ENOG4107FS9 Membrane FR848_03280 ENOG4105MG3 Membrane FR848_03285 ENOG4106H78 methyltransferase FR848_03290 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FR848_03295 ENOG4105CAK Cell division ATP-binding protein ftsE FR848_03300 ENOG4105CRP Part of the ABC transporter FtsEX involved in FR848_03315 ENOG4108JPW Aminotransferase FR848_03325 ENOG4105CP9 extracellular ligand-binding receptor FR848_03330 ENOG4105U59 -acetyltransferase FR848_03340 ENOG4105CP9 extracellular ligand-binding receptor FR848_03345 ENOG4105C32 Amino acid ABC transporter (Permease) FR848_03350 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FR848_03355 ENOG4105C0Z ABC transporter FR848_03360 ENOG4108IV0 ABC, transporter FR848_03365 ENOG4105CTX dehydratase FR848_03370 ENOG4105CSP Major Facilitator Superfamily FR848_03375 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FR848_03380 ENOG4107258 Transcriptional regulator FR848_03385 ENOG4105BZ7 extracellular solute-binding protein family 1 FR848_03390 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FR848_03405 ENOG4107T6V glycerophosphoryl diester phosphodiesterase FR848_03410 ENOG4105WC8 Conserved Protein FR848_03415 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FR848_03420 ENOG4105WCN acetyltransferase FR848_03430 ENOG4105D9R oxidoreductase FR848_03435 ENOG4105C2I pirin domain protein FR848_03440 ENOG4105DIQ Transcriptional regulator FR848_03445 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FR848_03450 ENOG4105C6Z Gluconate FR848_03460 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FR848_03465 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FR848_03485 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FR848_03490 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FR848_03500 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) FR848_03505 ENOG4105E98 transcriptional regulator DeoR family FR848_03520 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FR848_03525 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FR848_03540 ENOG4105VEJ Heat shock protein FR848_03545 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 FR848_03555 ENOG4107RK2 ADP-ribose diphosphatase NudE FR848_03560 ENOG4108JQC penicillin-binding protein 1A FR848_03585 ENOG4105E4G Type IV pilus FR848_03590 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FR848_03595 ENOG4105D49 3-dehydroquinate synthase FR848_03600 ENOG4105EGB membrane protein DamX FR848_03605 ENOG4105DFE Dna adenine methylase FR848_03610 ENOG4105DJV ribulose-phosphate 3-epimerase FR848_03620 ENOG4105C31 Tryptophanyl-tRNA synthetase FR848_03625 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FR848_03630 ENOG4107V9H nitrite transporter FR848_03635 ENOG4105WZK nitrite reductase NADPH small subunit FR848_03640 ENOG4107QZF nitrite reductase NADPH large subunit FR848_03645 ENOG4105DZC cytosine deaminase FR848_03650 ENOG4106DTQ Protein TsgA homolog FR848_03655 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FR848_03660 ENOG4106195 uncharacterized protein yhfG FR848_03665 ENOG4105MZU cell filamentation protein FR848_03675 ENOG4105C8Y Acetylornithine aminotransferase FR848_03680 ENOG410613R integral membrane protein, YccS YhfK family FR848_03690 ENOG4108UKZ OsmC family FR848_03695 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) FR848_03705 ENOG4105DNZ Alpha Beta Hydrolase FR848_03715 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FR848_03725 ENOG4105C5H ABC transporter FR848_03730 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FR848_03740 ENOG4105VKU nucleicacid-binding protein FR848_03745 ENOG4108YZY peptidylprolyl cis-trans isomerase FR848_03755 ENOG4108V1T peptidylprolyl cis-trans isomerase FR848_03760 ENOG4105WWK YheO domain protein FR848_03765 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) FR848_03775 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FR848_03790 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FR848_03795 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FR848_03800 ENOG4105W53 bacterioferritin-associated ferredoxin FR848_03805 ENOG4108UQY Iron-storage protein FR848_03825 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FR848_03840 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FR848_03850 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FR848_03855 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FR848_03865 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FR848_03870 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FR848_03875 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FR848_03880 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FR848_03900 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FR848_03905 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FR848_03910 ENOG4105VPB 50S ribosomal protein L30 FR848_03920 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FR848_03925 ENOG41067V7 50S ribosomal protein L36 FR848_03935 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FR848_03945 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FR848_03950 ENOG4108ZT0 50S ribosomal protein l17 FR848_03955 ENOG4105VTS DnaJ-like, subfamily C FR848_03960 ENOG4105W1Y Transcriptional regulator FR848_03965 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system FR848_03975 ENOG4105C1A potassium transporter peripheral membrane FR848_03985 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FR848_03995 ENOG4105C79 DNA protecting protein DprA FR848_04005 ENOG4108WI1 Dna topoisomerase FR848_04010 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FR848_04015 ENOG4105E2X shikimate dehydrogenase FR848_04020 ENOG4105SG3 Protein of unknown function (DUF1488) FR848_04025 ENOG4108Z0R Transferase FR848_04060 ENOG4105XCM membrane LIPOPROTEIN FR848_04065 ENOG4105BZS acriflavin resistance protein FR848_04070 ENOG4105C1P efflux transporter, rnd family, mfp subunit FR848_04075 ENOG4108XG4 DNA-binding transcriptional regulator FR848_04080 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FR848_04085 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FR848_04100 ENOG4108IA2 Sodium pantothenate symporter FR848_04105 ENOG4105RG0 Membrane FR848_04110 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FR848_04115 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FR848_04120 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) FR848_04130 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FR848_04135 ENOG41062P1 Diguanylate cyclase phosphodiesterase FR848_04140 ENOG4105DFF Rod shape-determining protein mreb FR848_04145 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FR848_04150 ENOG4105VQ7 Rod shape-determining protein MreD FR848_04160 ENOG4105C03 ribonuclease FR848_04165 ENOG4105QD6 exported protein FR848_04170 ENOG4105D1U peptidase U62 modulator of DNA gyrase FR848_04175 ENOG4107EDW L-fucose operon activator FR848_04180 ENOG4105CR8 Transcriptional regulator FR848_04195 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) FR848_04200 ENOG4105UNR (Barnase) inhibitor FR848_04205 ENOG4105RID UPF0379 protein yhcN FR848_04210 ENOG4105RID UPF0379 protein yhcN FR848_04225 ENOG4108WYP Transcriptional regulator FR848_04235 ENOG4105C8P )-transporter FR848_04240 ENOG4106DSS Tartrate dehydratase subunit alpha FR848_04245 ENOG4107GFK fumarate FR848_04255 ENOG4107QSA Oxaloacetate decarboxylase FR848_04260 ENOG4105D9Q decarboxylase (Beta subunit) FR848_04265 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase FR848_04270 ENOG4105C0H protease FR848_04275 ENOG4105C0H protease FR848_04280 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III FR848_04285 ENOG4105D6Z AFG1 family ATPase FR848_04300 ENOG4107MKT Stringent starvation protein a FR848_04305 ENOG4105KB2 stringent starvation protein b FR848_04320 ENOG4105JHE Major Facilitator Superfamily FR848_04330 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) FR848_04335 ENOG4108R66 Conserved Protein FR848_04340 ENOG4105BZ8 glutamate synthase FR848_04345 ENOG4105CBC glutamate synthase FR848_04355 ENOG4105N5T Radical SAM Protein FR848_04360 ENOG4105BZU Histidine kinase FR848_04365 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain FR848_04375 ENOG41080Z8 PHOSPHOCARRIER protein FR848_04380 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FR848_04385 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FR848_04390 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FR848_04395 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FR848_04400 ENOG4108IUZ ABC transporter FR848_04405 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FR848_04410 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) FR848_04415 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FR848_04420 ENOG4105C2X Arabinose 5-phosphate isomerase FR848_04425 ENOG4105FEU K -dependent Na -Ca exchanger FR848_04430 ENOG4105DHJ ABC, transporter FR848_04435 ENOG4105CY3 ABC transporter, permease FR848_04440 ENOG4107PE3 Mammalian cell entry related domain protein FR848_04445 ENOG4105E3I toluene tolerance FR848_04450 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane FR848_04455 ENOG4105VFK BolA family FR848_04465 ENOG4105HVQ Regulatory factor of maltose metabolism FR848_04470 ENOG4105EAH synthase FR848_04480 ENOG4105K46 50S ribosomal protein l27 FR848_04485 ENOG4105QYV Membrane FR848_04495 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FR848_04500 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FR848_04505 ENOG4105HBR Rna-binding protein FR848_04515 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FR848_04520 ENOG4105EEI dihydropteroate synthase FR848_04540 ENOG4105CDH Citrulline--aspartate ligase FR848_04555 ENOG4105CHV Transcription elongation factor NusA FR848_04560 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FR848_04570 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FR848_04575 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FR848_04580 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FR848_04595 ENOG4105C1J atp-dependent rna helicase FR848_04600 ENOG4105CIC tryptophan-specific transport protein FR848_04605 ENOG4105DEN Luciferase family FR848_04610 ENOG4106RZ4 Peptidase U32 FR848_04615 ENOG4105CFP Peptidase U32 FR848_04620 ENOG4105XPQ lipid carrier protein FR848_04625 ENOG4108YYD acetyltransferase FR848_04630 ENOG41082IR Excinuclease ABC C subunit domain protein FR848_04635 ENOG4108ZPB UPF0306 protein FR848_04640 ENOG4107R7Y intracellular protease Pfpi family FR848_04645 ENOG4105K4T epimerase FR848_04650 ENOG4107S21 permease FR848_04655 ENOG4105W4M Transport-associated protein FR848_04670 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) FR848_04675 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FR848_04685 ENOG4105D2N Aldolase FR848_04690 ENOG4105E70 isomerase FR848_04695 ENOG4105CE4 GlcNAc 6-P deacetylase FR848_04700 ENOG4108YTN IIa component FR848_04705 ENOG4105F3R pts system mannose fructose sorbose family iid FR848_04715 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB FR848_04720 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of FR848_04725 ENOG4105E98 transcriptional regulator DeoR family FR848_04730 ENOG4105CTX dehydratase FR848_04735 ENOG4105DJB Major Facilitator Superfamily FR848_04740 ENOG4105CNV Aldolase FR848_04745 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FR848_04750 ENOG4105BZW Glycerate kinase FR848_04765 ENOG4108CNN domain protein FR848_04770 ENOG4105CWB LysR family transcriptional Regulator FR848_04775 ENOG4105KAF membrAne FR848_04780 ENOG4105CHF Glutathione S-transferase FR848_04785 ENOG4108VBZ doxx family FR848_04790 ENOG4105YJD FR848_04795 ENOG41090KG Inner membrane protein YqjE FR848_04800 ENOG4105NE1 Conserved Protein FR848_04805 ENOG4105WAY exported protein FR848_04810 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) FR848_04815 ENOG4106W5V Membrane FR848_04820 ENOG4107YCY Transcriptional regulator FR848_04825 ENOG4105DPW Major facilitator superfamily MFS_1 FR848_04835 ENOG4105CTX dehydratase FR848_04840 ENOG4105P66 Membrane FR848_04850 ENOG4105DU1 integral membrane protein, terc FR848_04855 ENOG4105EE0 oxidoreductase FR848_04860 ENOG4108VKG metal-dependent hydrolase FR848_04865 ENOG4105DSG hydrolase family 43 FR848_04875 ENOG4105CT4 transporter FR848_04880 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FR848_04885 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FR848_04890 ENOG4107RYS Autoinducer-2 (AI-2) kinase FR848_04895 ENOG4105DKT Transcriptional regulator FR848_04900 ENOG4105C2J ABC transporter FR848_04905 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FR848_04910 ENOG4105F5R ABC transporter FR848_04915 ENOG4105D4B ABC, transporter FR848_04920 ENOG41061GT Aldolase FR848_04925 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound FR848_04930 ENOG4107WCA isomerase FR848_04935 ENOG4107W6W Conserved Protein FR848_04940 ENOG4105E5D amino acid FR848_04945 ENOG4105E5D amino acid FR848_04950 ENOG4105FK9 beta-D-galactosidase beta subunit FR848_04955 ENOG4105CNT hydrolase family 2 FR848_04965 ENOG4105CQ4 Transcriptional regulator FR848_04970 ENOG4108Y51 tRNA-binding protein FR848_04975 ENOG4105C8Y Acetylornithine aminotransferase FR848_04980 ENOG4105NTW Transcriptional regulator FR848_04985 ENOG4105Q26 Siderophore-interacting protein FR848_05000 ENOG4108UTZ Dihydroxyacetone kinase FR848_05005 ENOG4105CMT Dihydroxyacetone kinase FR848_05020 ENOG4105V2F Uncharacterized protein yoac FR848_05040 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FR848_05045 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FR848_05050 ENOG4105VCC 30S ribosomal protein S21 FR848_05055 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FR848_05065 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) FR848_05070 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FR848_05075 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) FR848_05090 ENOG4108YZ9 Urea amidohydrolase subunit gamma FR848_05095 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FR848_05100 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FR848_05105 ENOG4107ZVW dihydroneopterin aldolase FR848_05115 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FR848_05120 ENOG4106MWK domain protein FR848_05125 ENOG4105I7R Adenylate cyclase FR848_05145 ENOG4105W0Z cytoplasmic protein FR848_05155 ENOG4108MY7 Fimbrial FR848_05160 ENOG4108TTM chaperone FR848_05170 ENOG4105H8W Fimbrial protein FR848_05175 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) FR848_05180 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FR848_05185 ENOG4106032 Glutathionylspermidine synthase FR848_05190 ENOG4105F1G UPF0441 protein FR848_05200 ENOG41087AY ADP-Ribose pyrophosphatase FR848_05205 ENOG4108SX3 cytoplasmic protein FR848_05210 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FR848_05215 ENOG4105IPS esterase FR848_05220 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FR848_05225 ENOG4105VRH Antibiotic biosynthesis monooxygenase FR848_05230 ENOG4105NF4 modulator of drug activity FR848_05235 ENOG4105DHQ Histidine kinase FR848_05240 ENOG4105XJC Two component transcriptional regulator (Winged helix family FR848_05245 ENOG4105H4F exported protein FR848_05250 ENOG4105F4I Transcriptional regulator FR848_05255 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FR848_05260 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FR848_05265 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) FR848_05270 ENOG4105CCT upf0313 protein FR848_05305 ENOG4105WAB arsR family transcriptional regulator FR848_05310 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FR848_05315 ENOG4105EQ2 LysR family Transcriptional regulator FR848_05325 ENOG4107RT3 EamA-like transporter family FR848_05350 ENOG4105E2A Dehydrogenase FR848_05380 ENOG4105EKQ RNA-directed DNA polymerase FR848_05430 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FR848_05465 ENOG4105CCT upf0313 protein FR848_05475 ENOG4105CV8 reductase FR848_05480 ENOG4108I6A alcohol dehydrogenase FR848_05485 ENOG4105CF7 AraC family transcriptional regulator FR848_05490 ENOG4108K81 inner membrane protein YghB FR848_05495 ENOG4105C28 cystathionine FR848_05500 ENOG4105CWK Biopolymer transport protein, ExbB FR848_05505 ENOG4108ZZF transport protein (ExbD) FR848_05510 ENOG4108TEB UPF0114 protein FR848_05520 ENOG410900S Protein of unknown function (DUF2623) FR848_05525 ENOG4105CYM Glutathione S-transferase FR848_05535 ENOG4106032 Glutathionylspermidine synthase FR848_05540 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FR848_05550 ENOG4105M2Z protein tyrosine serine phosphatase FR848_05570 ENOG4105C28 cystathionine FR848_05585 ENOG4105C8P )-transporter FR848_05600 ENOG4108UQV Membrane FR848_05605 ENOG4105CXN decarboxylase FR848_05610 ENOG4105EAA nucleoside FR848_05620 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) FR848_05625 ENOG4105CEN a g-specific adenine glycosylase FR848_05630 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FR848_05635 ENOG41090ED Protein with unknown function (DUF469) FR848_05640 ENOG4105K33 Periplasmic Protein FR848_05645 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FR848_05650 ENOG41069H7 transport system small permease component FR848_05655 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FR848_05660 ENOG4105CSA Coproporphyrinogen iii oxidase FR848_05665 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FR848_05670 ENOG4105VZ9 UPF0235 protein FR848_05675 ENOG4108VIA integral membrane protein FR848_05680 ENOG4105DFA alanine racemase domain protein FR848_05685 ENOG4105CZX twitching motility protein FR848_05690 ENOG41086KC Transcriptional regulator FR848_05700 ENOG4108UJU UPF0301 protein FR848_05705 ENOG4105D7Z glutathione synthase FR848_05710 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FR848_05715 ENOG4105RWS endonuclease I FR848_05725 ENOG4107QNK )-transporter FR848_05730 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FR848_05740 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) FR848_05750 ENOG4108K0D peptidase, M48 FR848_05755 ENOG4105CV1 Transketolase (EC 2.2.1.1) FR848_05760 ENOG4108JJB ABC transporter FR848_05795 ENOG4105D2N Aldolase FR848_05800 ENOG4105D64 Mechanosensitive ion channel FR848_05810 ENOG4105MPN Membrane FR848_05815 ENOG4105DEQ transcriptional regulator FR848_05820 ENOG4105CYC Transferase FR848_05825 ENOG4108M7F enoyl-CoA hydratase isomerase FR848_05830 ENOG4105DJT lAO AO transport system ATPase FR848_05835 ENOG4105D5P Methylmalonyl-coA mutase FR848_05840 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FR848_05845 ENOG4105E66 phosphoriboisomerase A FR848_05850 ENOG4108JQ1 Dehydrogenase FR848_05855 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FR848_05875 ENOG4107RAQ aminopeptidase FR848_05880 ENOG4105D0A hydroxylase FR848_05885 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FR848_05890 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FR848_05905 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FR848_05910 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FR848_05915 ENOG4105CS2 ec 3.2.1.21 FR848_05920 ENOG4108Q3X Transcriptional regulator FR848_05925 ENOG4105N5Z UPF0267 protein FR848_05930 ENOG4108UT2 hemolysin iii FR848_05945 ENOG4105F3R pts system mannose fructose sorbose family iid FR848_05950 ENOG4105ETZ PTS System FR848_05955 ENOG4108EQA pts system FR848_05975 ENOG4105Y75 tpr repeat protein FR848_05980 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB FR848_05985 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) FR848_05990 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FR848_05995 ENOG4105T95 Thiol disulfide interChange protein FR848_06000 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FR848_06010 ENOG4105CRK lysyL-tRNA synthetase FR848_06020 ENOG4108UQV Membrane FR848_06025 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FR848_06030 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FR848_06035 ENOG4106P55 Transcriptional regulator FR848_06040 ENOG4108K5P (LipO)protein FR848_06050 ENOG4105DFP Integrase FR848_06060 ENOG4105XEA Tetr family transcriptional regulator FR848_06065 ENOG4105EQ2 LysR family Transcriptional regulator FR848_06070 ENOG4105DQ4 alcohol dehydrogenase FR848_06085 ENOG4105EMU Dehydrogenase FR848_06090 ENOG4105F9N Major Facilitator Superfamily FR848_06095 ENOG4105ENX hydrolase FR848_06120 ENOG4105CGD Nad-dependent epimerase dehydratase FR848_06125 ENOG4105EQ2 LysR family Transcriptional regulator FR848_06130 ENOG4107SET aldo keto reductase FR848_06165 ENOG4105GR3 Histidine kinase FR848_06175 ENOG4105CPC Aldo Keto reductase FR848_06180 ENOG4105ENX hydrolase FR848_06185 ENOG4108TKH Nitroreductase FR848_06190 ENOG4105C2C drug resistance transporter, Bcr CflA FR848_06210 ENOG4105K89 arsenate reductase FR848_06215 ENOG41083G8 Multidrug resistance protein MdtM FR848_06230 ENOG4107VHA regulatoR FR848_06235 ENOG4105BZW Glycerate kinase FR848_06255 ENOG4105CHU acetyl-coa acetyltransferase FR848_06260 ENOG4105CHR reductase FR848_06265 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) FR848_06270 ENOG4105CEY Amp-dependent synthetase and ligase FR848_06280 ENOG4105EDR glucose galactose transporter FR848_06285 ENOG4108RVA ribokinase FR848_06290 ENOG4105UP7 3-epimerase FR848_06295 ENOG4105E98 transcriptional regulator DeoR family FR848_06300 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FR848_06305 ENOG4105CMG Carbohydrate kinase FR848_06325 ENOG4105DUX Transporter FR848_06330 ENOG4105CHR reductase FR848_06335 ENOG41061ZR Transcriptional regulator FR848_06340 ENOG4105ETP RND efflux system, outer membrane lipoprotein FR848_06345 ENOG4108MI0 Resistance protein FR848_06350 ENOG4105J12 Multidrug resistance protein mdtN FR848_06360 ENOG4105VR1 Pfam:DUF1271 FR848_06365 ENOG410830R acetyltransferase FR848_06370 ENOG4108NIW Leucine export protein LeuE FR848_06375 ENOG4105EW9 transcriptional regulator AsnC family FR848_06380 ENOG4108ZT1 Transcriptional regulator FR848_06385 ENOG4108KTG Membrane protein, drug metabolite transporter FR848_06405 ENOG4108ZHR arsR family transcriptional regulator FR848_06410 ENOG4108T1W Fimbrial subunit type 3 FR848_06450 ENOG4107S5I aldo keto reductase FR848_06455 ENOG4108MHD transport protein FR848_06465 ENOG4105C5Q Transcriptional regulator FR848_06470 ENOG4105CHU acetyl-coa acetyltransferase FR848_06475 ENOG4108QGT oligogalacturonate-specific porin FR848_06480 ENOG4105CAZ oligogalacturonide lyase FR848_06485 ENOG4105CHR reductase FR848_06490 ENOG4107QNK )-transporter FR848_06495 ENOG4106NDP Transcriptional regulator FR848_06500 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FR848_06505 ENOG4108HKT sucrose-6-phosphate hydrolase FR848_06515 ENOG4105CAZ oligogalacturonide lyase FR848_06530 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FR848_06535 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FR848_06555 ENOG4105E6S usher protein( FR848_06560 ENOG4108S1B Periplasmic chaperone protein FR848_06570 ENOG4105UMR response to DNA damage stimulus FR848_06575 ENOG4105RQF LysR family Transcriptional regulator FR848_06580 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FR848_06585 ENOG4105DDV Transcriptional regulator (LacI family FR848_06590 ENOG4105CK1 PTS System FR848_06595 ENOG4105CS2 ec 3.2.1.21 FR848_06600 ENOG4107YCY Transcriptional regulator FR848_06610 ENOG41060NJ transcriptional regulator FR848_06620 ENOG4107S74 Lysophospholipid transporter LplT FR848_06625 ENOG4105CPC Aldo Keto reductase FR848_06630 ENOG4105SUV lipoprotein YgdR FR848_06635 ENOG4105EE5 Membrane protein terC FR848_06640 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) FR848_06655 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FR848_06660 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FR848_06665 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FR848_06675 ENOG4105IPU prepilin peptidase dependent protein A FR848_06680 ENOG4105JCS prepilin peptidase dependent protein FR848_06685 ENOG4105SEN Protein of unknown function (DUF2509) FR848_06690 ENOG4105RVB Prepilin peptidase dependent protein c FR848_06695 ENOG4105DSY exodeoxyribonuclease V, gamma FR848_06700 ENOG4107QXK peptidase FR848_06705 ENOG4107QKA exodeoxyribonuclease V beta FR848_06710 ENOG4107QYX exodeoxyribonuclease v alpha FR848_06715 ENOG4107QZM n-acetylglutamate synthase FR848_06720 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FR848_06725 ENOG4107QZB decarboxylase FR848_06730 ENOG4105JZC GHMP kinase FR848_06735 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FR848_06740 ENOG4105KTW ethanolamine utilization protein FR848_06745 ENOG4105M3W utilization protein FR848_06755 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) FR848_06760 ENOG4108EKI Dehydrogenase FR848_06765 ENOG4108EKI Dehydrogenase FR848_06775 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml FR848_06785 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) FR848_06790 ENOG4105S3V Carbon dioxide concentrating mechanism protein FR848_06795 ENOG4105KNY Microcompartments protein FR848_06805 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit FR848_06810 ENOG4108ZFT Dehydratase small subunit FR848_06815 ENOG4105YCI dehydratase medium subunit FR848_06820 ENOG4105DMB glycerol dehydratase FR848_06825 ENOG4105EHR propanediol utilization protein pduB FR848_06830 ENOG4105KNY Microcompartments protein FR848_06835 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FR848_06840 ENOG4107XVH Transcriptional regulator FR848_06845 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FR848_06850 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FR848_06855 ENOG41081F0 Precorrin-8x methylmutase FR848_06860 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) FR848_06865 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase FR848_06870 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase FR848_06875 ENOG4105CIA precorrin-4 C(11)-methyltransferase FR848_06880 ENOG4108P62 biosynthesis protein (CbiG) FR848_06885 ENOG4105E4R Precorrin-3B C17-methyltransferase FR848_06890 ENOG4105QUC reductase FR848_06895 ENOG4107PPM cobalt chelatase FR848_06900 ENOG4105DVK Precorrin-2 c20-methyltransferase FR848_06905 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) FR848_06910 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) FR848_06915 ENOG4108V4M Cobalt abc transporter FR848_06925 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FR848_06930 ENOG4108YZT Adenosylcobinamide kinase FR848_06955 ENOG4105CA3 membrane-bound lytic murein transglycosylase FR848_06960 ENOG4105CUZ uba thif-type nad fad binding protein FR848_06965 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FR848_06970 ENOG4105C9B Cysteine desulfurase FR848_06975 ENOG4105M5B (LipO)protein FR848_06980 ENOG4105ETT transcriptional Regulator, LysR family FR848_06985 ENOG4105M08 Membrane FR848_06995 ENOG4107EDW L-fucose operon activator FR848_07005 ENOG4105CMG Carbohydrate kinase FR848_07010 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) FR848_07015 ENOG4105EDR glucose galactose transporter FR848_07020 ENOG4107W7X Aldolase FR848_07030 ENOG4108JU7 Transcriptional regulator FR848_07035 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FR848_07050 ENOG4105GVF (ABC) transporter FR848_07055 ENOG4105EJQ L-serine dehydratase FR848_07060 ENOG4105C44 Serine transporter FR848_07065 ENOG4105EWT decarboxylase family FR848_07075 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) FR848_07080 ENOG4105WP7 tRNA pseudouridine synthase C FR848_07085 ENOG4105DR9 pseudouridine synthase FR848_07090 ENOG4105QDK Flavodoxin FR848_07100 ENOG4105DJB Major Facilitator Superfamily FR848_07105 ENOG4105EQX glucarate dehydratase FR848_07110 ENOG4105EQX glucarate dehydratase FR848_07115 ENOG4105BZW Glycerate kinase FR848_07120 ENOG4105BZU Histidine kinase FR848_07130 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FR848_07135 ENOG4105DXN mazG family FR848_07140 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FR848_07155 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FR848_07160 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FR848_07165 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FR848_07180 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FR848_07200 ENOG4105FDR Membrane FR848_07215 ENOG4108MXK alkaline phosphatase isozyme conversion FR848_07220 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FR848_07240 ENOG4105N0Z inner membrane protein ygbE FR848_07250 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FR848_07260 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) FR848_07270 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FR848_07275 ENOG4108K5P (LipO)protein FR848_07280 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FR848_07290 ENOG4105C0R drug resistance transporter emrb qaca subfamily FR848_07295 ENOG4105JQN Transcriptional regulator FR848_07305 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FR848_07310 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FR848_07315 ENOG4105KZM cytoplasmic protein FR848_07325 ENOG4107635 Hok Gef family protein FR848_07330 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FR848_07335 ENOG4108TH4 Major fimbrial subunit FR848_07345 ENOG4106PG1 outer membrane usher protein FR848_07350 ENOG4108FZ9 Chaperone FR848_07360 ENOG4108MDY Fimbrial FR848_07390 ENOG4105BZ1 (ABC) transporter FR848_07395 ENOG4105DJY efflux transporter, rnd family, mfp subunit FR848_07405 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FR848_07425 ENOG4105CHR reductase FR848_07455 ENOG4105C0A alcohol dehydrogenase FR848_07460 ENOG41073TP transcriptional regulator FR848_07465 ENOG4105CPQ Dehydrogenase FR848_07470 ENOG4105DJB Major Facilitator Superfamily FR848_07475 ENOG4105CHR reductase FR848_07485 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FR848_07490 ENOG4105EHG Permease protein FR848_07495 ENOG4107R4I Periplasmic binding protein FR848_07500 ENOG4106QJH hemin transport protein FR848_07515 ENOG4105VXR cytoplasmic protein FR848_07520 ENOG4105CC5 ABC transporter FR848_07525 ENOG4105CC5 ABC transporter FR848_07530 ENOG4105DIK (ABC) transporter FR848_07540 ENOG4105DDV Transcriptional regulator (LacI family FR848_07545 ENOG4105DKQ ROK family FR848_07550 ENOG4105VCP PTS System FR848_07555 ENOG4105CK1 PTS System FR848_07560 ENOG4105VZJ PTS System FR848_07565 ENOG4105CK1 PTS System FR848_07570 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FR848_07580 ENOG4105CS2 ec 3.2.1.21 FR848_07595 ENOG4105C45 hydrogenase expression formation protein (HypE) FR848_07600 ENOG4105CQS hydrogenase expression formation protein HypD FR848_07605 ENOG41083WG hydrogenase assembly chaperone FR848_07610 ENOG4107RSS Hydrogenase accessory protein HypB FR848_07620 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA FR848_07625 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) FR848_07630 ENOG4107R30 NADH dehydrogenase FR848_07635 ENOG4107TDF Formate hydrogenlyase subunit 4 FR848_07640 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FR848_07645 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit FR848_07650 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit FR848_07655 ENOG4105I6X formate hydrogenlyase maturation FR848_07660 ENOG4108MG9 hydrogenase 3 maturation protease FR848_07670 ENOG4105CS2 ec 3.2.1.21 FR848_07675 ENOG4105C5Y PTS System FR848_07685 ENOG4105DDV Transcriptional regulator (LacI family FR848_07690 ENOG4108RC0 Electron transport protein FR848_07695 ENOG4105C8H hydrogenase maturation protein Hypf FR848_07720 ENOG4108JUA Transcriptional regulator FR848_07730 ENOG410804X Transcriptional regulator FR848_07735 ENOG4105J92 DNA-binding transcriptional activator GutM FR848_07740 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase FR848_07745 ENOG4105VI0 Pts system, glucitol sorbitol-specific FR848_07750 ENOG4105DZY Pts system, glucitol sorbitol-specific FR848_07755 ENOG410787A Pts system, glucitol sorbitol-specific FR848_07760 ENOG4105CVE Lytic murein transglycosylase FR848_07765 ENOG4105DIK (ABC) transporter FR848_07770 ENOG4105CC5 ABC transporter FR848_07775 ENOG4105DSE periplasmic solute binding protein FR848_07785 ENOG4107TH8 cina domain protein FR848_07800 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FR848_07805 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FR848_07835 ENOG4105K3G Periplasmic Protein FR848_07840 ENOG4107VXZ Hydrolase FR848_07845 ENOG4105W39 Membrane FR848_07865 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FR848_07870 ENOG4105C0R drug resistance transporter emrb qaca subfamily FR848_07875 ENOG4105CW7 secretion protein, HlyD family FR848_07880 ENOG4105NTK Transcriptional repressor Mpra FR848_07885 ENOG4105ZED uncharacterized protein ygaH FR848_07890 ENOG4108UMN azlc family FR848_07895 ENOG4105GIJ Glycine betaine FR848_07900 ENOG4108HQS Glycine betaine FR848_07905 ENOG4108IJ7 Glycine betaine FR848_07910 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FR848_07915 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FR848_07925 ENOG4105WAZ (Glutaredoxin-like protein) NrdH FR848_07930 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FR848_07940 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) FR848_07945 ENOG4108WMJ Protein of unknown function (DUF2002) FR848_07950 ENOG4108RNS Exports L-alanine (By similarity) FR848_07960 ENOG4108X73 DNA- binding protein FR848_07970 ENOG4108V62 Rhodanese domain protein FR848_07975 ENOG41080HT Transcriptional regulator, arsr family FR848_07980 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FR848_07985 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FR848_07990 ENOG4105C26 Dehydrogenase FR848_08005 ENOG4108VCD Chaperone FR848_08010 ENOG4105CW0 outer membrane usher protein FR848_08020 ENOG4105EQK -acetyltransferase FR848_08025 ENOG4105E89 ABC transporter FR848_08035 ENOG4105CHR reductase FR848_08040 ENOG4105DXI Major Facilitator superfamily FR848_08045 ENOG4105CA0 peroxidase FR848_08055 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FR848_08060 ENOG41060IM Heme exporter protein FR848_08065 ENOG4105X3C heme exporter protein FR848_08075 ENOG4105DA4 cytochrome c-type biogenesis protein FR848_08080 ENOG4107QX9 Thiol disulfide interChange protein FR848_08085 ENOG4105KWW Biogenesis protein FR848_08095 ENOG4105MP9 class II Aldolase FR848_08100 ENOG4105CDA abc transporter atp-binding protein FR848_08105 ENOG4106TNF Periplasmic binding protein FR848_08120 ENOG4105CYW agmatinase FR848_08125 ENOG4105EVZ LysR family transcriptional regulator FR848_08145 ENOG4108WQH regulatoR FR848_08150 ENOG4105BZU Histidine kinase FR848_08165 ENOG4108VCD Chaperone FR848_08170 ENOG4105CW0 outer membrane usher protein FR848_08205 ENOG4107R08 Integrase FR848_08295 ENOG4105HGD Antitermination protein FR848_08355 ENOG4105CAR Terminase, large subunit FR848_08360 ENOG4105EFC phage portal protein HK97 family FR848_08365 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FR848_08485 ENOG4106FE3 DNA repair FR848_08500 ENOG4108Z1B Cyclase dehydrase FR848_08510 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FR848_08515 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FR848_08530 ENOG4108JU6 CBS domain protein FR848_08535 ENOG4106KVJ cytochrome C assembly protein FR848_08540 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FR848_08550 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FR848_08560 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FR848_08575 ENOG41090EK ompa motb domain protein FR848_08580 ENOG4108KHX Diguanylate cyclase FR848_08585 ENOG4108WS1 FR848_08590 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FR848_08595 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FR848_08605 ENOG4105CQC Prephenate dehydratase FR848_08615 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA FR848_08620 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FR848_08625 ENOG4105C34 Pseudouridine synthase FR848_08630 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FR848_08635 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FR848_08665 ENOG4105CSH Transporter FR848_08670 ENOG4105T42 (LipO)protein FR848_08675 ENOG4105JIM Phosphatidylserine synthase FR848_08680 ENOG4105CD5 CoA-binding domain protein FR848_08685 ENOG4106IUH DTW domain containing protein FR848_08690 ENOG4105K63 Thioredoxin FR848_08695 ENOG4105EIB trna rrna methyltransferase FR848_08700 ENOG4105VNT transposase (IS4 family) protein FR848_08715 ENOG4105C1J atp-dependent rna helicase FR848_08720 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) FR848_08725 ENOG4108IYU L-aspartate oxidase FR848_08740 ENOG41069PW sigma-e factor negative regulatory protein FR848_08745 ENOG4105VQK sigma E regulatory protein, MucB RseB FR848_08750 ENOG4105WMJ Positive regulator of sigma E, RseC MucC FR848_08760 ENOG4105C3F Signal peptidase i FR848_08775 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FR848_08780 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FR848_08790 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FR848_08795 ENOG4106G6Q Transcriptional regulator FR848_08800 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB FR848_08805 ENOG4108Z6B deaminase FR848_08810 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FR848_08820 ENOG4108ETH Formylglycinamide ribotide synthetase FR848_08825 ENOG4107WP9 Histidine kinase FR848_08830 ENOG4108SKK alpha helix protein FR848_08835 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FR848_08840 ENOG4108YZA Nitrogen regulatory protein pii FR848_08845 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FR848_08855 ENOG4108SB3 DoxX Family FR848_08860 ENOG4108NZE NAGC-like transcriptional regulator FR848_08865 ENOG4107HQ7 repeat protein FR848_08870 ENOG4107QNK )-transporter FR848_08875 ENOG4108ZKT aldose 1-epimerase FR848_08880 ENOG4105D8G Major Facilitator superfamily FR848_08885 ENOG4108MN2 Stationary phase inducible protein CsiE FR848_08890 ENOG41065CD Exported protein FR848_08895 ENOG4105D7X high-affinity nickel-transporter FR848_08900 ENOG4105ECY inositol monophosphatase FR848_08905 ENOG4105CVS RNA methyltransferase TrmH family, group 1 FR848_08910 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family FR848_08920 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FR848_08935 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB FR848_08940 ENOG4108ZIT Ferredoxin, 2FE-2S FR848_08945 ENOG4105WVQ Fe-S assembly protein IscX FR848_08955 ENOG4105YYA enhanced serine sensitivity protein SseB FR848_08960 ENOG4105KHC sulfurtransferase FR848_08965 ENOG4105CH2 amidohydrolase FR848_08975 ENOG4105DN3 alpha-2-macroglobulin domain protein FR848_08980 ENOG4108JQB penicillin-binding protein 1C FR848_09000 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FR848_09010 ENOG4105N21 Membrane FR848_09015 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FR848_09020 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FR848_09035 ENOG4105VPD cellular component movement FR848_09045 ENOG4105D4Y metalloprotease FR848_09050 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FR848_09055 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FR848_09060 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FR848_09075 ENOG41062G3 Protein of unknown function (DUF2633) FR848_09080 ENOG4105BZU Histidine kinase FR848_09085 ENOG4105C9X ppx gppa phosphatase FR848_09090 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FR848_09105 ENOG4105CT4 transporter FR848_09115 ENOG4108V3E phosphoribosylglycinamide formyltransferase FR848_09125 ENOG41066F8 ROK family FR848_09130 ENOG4105CS2 ec 3.2.1.21 FR848_09135 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FR848_09140 ENOG4105C2W permease FR848_09145 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) FR848_09150 ENOG4105K89 arsenate reductase FR848_09155 ENOG4105ERG peptidase m48, ste24p FR848_09160 ENOG4105C02 permease FR848_09165 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FR848_09170 ENOG4105RH4 Glycine cleavage system transcriptional repressor FR848_09175 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FR848_09180 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FR848_09190 ENOG4105CGZ zinc metallopeptidase FR848_09195 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) FR848_09200 ENOG4106KED esterase YpfH FR848_09215 ENOG4105XYK UPF0370 protein FR848_09225 ENOG4105KUZ arsenate reductase FR848_09235 ENOG4105BZS acriflavin resistance protein FR848_09240 ENOG4105BZ8 glutamate synthase FR848_09245 ENOG4107VIJ nudix hydrolase FR848_09250 ENOG4108PVD exported protein FR848_09255 ENOG4105CV1 Transketolase (EC 2.2.1.1) FR848_09260 ENOG4105C6K Malic enzyme FR848_09265 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place FR848_09270 ENOG4106S4J ethanolamine utilization protein EutP FR848_09275 ENOG4105NDK ethanolamine utilization protein FR848_09280 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase FR848_09285 ENOG4108IJ2 phosphate acetyltransferase FR848_09290 ENOG4105KNY Microcompartments protein FR848_09295 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml FR848_09300 ENOG4108EKI Dehydrogenase FR848_09305 ENOG4107RWI ethanolamine utilization protein eutJ FR848_09310 ENOG4105C0A alcohol dehydrogenase FR848_09325 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase FR848_09330 ENOG4105CPD ethanolamine ammonia-lyase FR848_09340 ENOG4106D67 ethanolamine utilization protein FR848_09345 ENOG4108X49 Ethanolamine utilization protein EutK FR848_09350 ENOG4108K3Z AraC family transcriptional regulator FR848_09360 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase FR848_09370 ENOG4105QZU Inner membrane protein YfeZ FR848_09375 ENOG4105E7K (LipO)protein FR848_09380 ENOG4105EZR dyp-type peroxidase family protein FR848_09385 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein FR848_09390 ENOG4108I5D sulfate abc transporter FR848_09395 ENOG4105ECW sulfate abc transporter FR848_09400 ENOG4108IJ6 ABC transporter FR848_09405 ENOG4105C6T cysteine synthase FR848_09410 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein FR848_09415 ENOG41089BK Glutamine amido-transferase FR848_09420 ENOG4105CSW GntR family transcriptional regulator FR848_09435 ENOG4105C5Y PTS System FR848_09445 ENOG4105KZ7 phosphocarrier protein hpr FR848_09455 ENOG4105C6T cysteine synthase FR848_09460 ENOG4105EXN Sulfate transport protein CysZ FR848_09470 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FR848_09475 ENOG4105VRT cytoplasmic protein FR848_09480 ENOG4105DHU Bile acid FR848_09485 ENOG4108M0I Transcriptional regulator FR848_09490 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) FR848_09495 ENOG4105EAA nucleoside FR848_09500 ENOG4105CN8 Transcriptional regulator FR848_09525 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FR848_09530 ENOG4105GXM Putative transcription regulator (DUF1323) FR848_09535 ENOG4105HZG regulatoR FR848_09550 ENOG4108KMM Diguanylate cyclase FR848_09555 ENOG4105D9N nucleoside FR848_09560 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FR848_09565 ENOG4109076 Conserved Protein FR848_09570 ENOG4105CPC Aldo Keto reductase FR848_09575 ENOG4107RA9 decarboxylase FR848_09585 ENOG4105CHC glucokinase (EC 2.7.1.2) FR848_09590 ENOG4105DY9 regulatoR FR848_09595 ENOG4108HRK Histidine kinase FR848_09600 ENOG4105CHM Aminotransferase FR848_09610 ENOG4105DJ2 Major Facilitator Superfamily FR848_09615 ENOG4105DND Transcriptional regulator FR848_09640 ENOG4105S64 Formate nitrite transporter FR848_09645 ENOG410903C (LipO)protein FR848_09650 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FR848_09655 ENOG4105KZW UPF0381 protein FR848_09665 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FR848_09670 ENOG4108BY2 phosphohistidine phosphatase FR848_09680 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FR848_09685 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FR848_09695 ENOG4105EJ9 Membrane FR848_09700 ENOG4108BPE -transporting atpase FR848_09705 ENOG4105MH2 YfcL protein FR848_09710 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FR848_09715 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FR848_09725 ENOG4106WZ1 flagella biosynthesis regulator FR848_09735 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FR848_09745 ENOG4105DQR SNARE associated Golgi FR848_09750 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FR848_09755 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FR848_09760 ENOG4108S3P Sporulation domain protein FR848_09765 ENOG4105E96 Colicin v production protein FR848_09770 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FR848_09775 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FR848_09780 ENOG4105E89 ABC transporter FR848_09785 ENOG4105E89 ABC transporter FR848_09790 ENOG4105DSP amino acid AbC transporter FR848_09795 ENOG4106YG3 ABC transporter FR848_09800 ENOG4108JEH abc transporter atp-binding protein FR848_09805 ENOG4105KNA -acetyltransferase FR848_09820 ENOG4105ECP epimerase FR848_09825 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase FR848_09830 ENOG4105CYM Glutathione S-transferase FR848_09835 ENOG4108SHQ Glutathione S-transferase FR848_09840 ENOG4108RE9 Phosphodiesterase FR848_09845 ENOG4105PTV Nudix Hydrolase FR848_09850 ENOG4105K2J Transcriptional regulator FR848_09855 ENOG4106ETB IIa component FR848_09865 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC FR848_09870 ENOG4108HHA Transketolase FR848_09875 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FR848_09880 ENOG4105C6K Malic enzyme FR848_09885 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FR848_09900 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FR848_09905 ENOG4107QWE )-transporter FR848_09915 ENOG4105CHM Aminotransferase FR848_09920 ENOG4107NQ8 LysR family Transcriptional regulator FR848_09930 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FR848_09940 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FR848_09945 ENOG4105GKE subunit e FR848_09950 ENOG4107QIZ NADH dehydrogenase FR848_09955 ENOG4107R0R NADH dehydrogenase subunit g FR848_09970 ENOG4107UFS subunit j FR848_09975 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FR848_09980 ENOG4105D65 subunit l FR848_09985 ENOG4105C8S subunit m FR848_09990 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FR848_09995 ENOG4108W9T type 1 fimbriae regulatory protein FR848_10005 ENOG4108VCD Chaperone FR848_10010 ENOG4105CW0 outer membrane usher protein FR848_10015 ENOG4105MHR Fimbrial protein FR848_10025 ENOG4108W9T type 1 fimbriae regulatory protein FR848_10030 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FR848_10035 ENOG4107YB6 acetyltransferase, (GNAT) family FR848_10040 ENOG4105E4F Isochorismate synthase FR848_10050 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FR848_10055 ENOG4108IPT Naphthoate synthase FR848_10060 ENOG4105DNI Converts SHCHC to OSB (By similarity) FR848_10065 ENOG4105CEY Amp-dependent synthetase and ligase FR848_10070 ENOG4108R5S membrane FR848_10095 ENOG4105DHQ Histidine kinase FR848_10100 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) FR848_10110 ENOG4105CH6 catalase FR848_10115 ENOG4108UII YfaZ family FR848_10125 ENOG4107258 Transcriptional regulator FR848_10135 ENOG4105CSP Major Facilitator Superfamily FR848_10140 ENOG4105CNV Aldolase FR848_10145 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FR848_10150 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FR848_10155 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A FR848_10160 ENOG4105CXY transporter FR848_10165 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FR848_10170 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FR848_10175 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FR848_10180 ENOG4105XPH Ferredoxin FR848_10185 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FR848_10190 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FR848_10200 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FR848_10205 ENOG4105BZU Histidine kinase FR848_10210 ENOG41068CG regulatoR FR848_10215 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC FR848_10235 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FR848_10240 ENOG4105CF1 Alkylated DNA repair protein FR848_10245 ENOG4105IBP Cyclic peptide transporter FR848_10250 ENOG4105CJW magnesium transporter FR848_10255 ENOG4105CHH sulfate transporter FR848_10270 ENOG4105F4G Membrane FR848_10330 ENOG4105VRS hydrolase family 18 FR848_10400 ENOG4105E68 Sulfatase FR848_10405 ENOG4105PAN UPF0352 protein FR848_10410 ENOG4106V8H Nucleoid-associated protein FR848_10415 ENOG4105E98 transcriptional regulator DeoR family FR848_10420 ENOG4107VIJ nudix hydrolase FR848_10425 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FR848_10430 ENOG4105CFI type iii restriction protein res subunit FR848_10435 ENOG4105I08 Pseudouridine synthase FR848_10440 ENOG4105C2C drug resistance transporter, Bcr CflA FR848_10445 ENOG4105HG6 FR848_10450 ENOG4108JQ5 ABC transporter FR848_10455 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FR848_10460 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FR848_10465 ENOG4105E43 Extracellular solute-binding protein, family 5 FR848_10470 ENOG4105CXC rtn protein FR848_10475 ENOG4107TT5 NLP P60 protein FR848_10480 ENOG41076MN Phosphoesterase, PA-phosphatase related FR848_10485 ENOG4105CKI cobalamin synthesis protein FR848_10490 ENOG4105DEI Mannitol dehydrogenase FR848_10495 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FR848_10500 ENOG4105KRS Proteinase inhibitor FR848_10505 ENOG4105S8Q sugar efflux transporter FR848_10510 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FR848_10515 ENOG4105DE4 1-phosphofructokinase FR848_10520 ENOG4105DM4 PTS System FR848_10525 ENOG4105DD7 kinase (PfkB family FR848_10530 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) FR848_10535 ENOG4105D9N nucleoside FR848_10540 ENOG4105DD7 kinase (PfkB family FR848_10545 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FR848_10550 ENOG4105HMI Membrane FR848_10555 ENOG4105DUM transcriptional regulator, lysR family FR848_10560 ENOG4108IQI permease FR848_10565 ENOG4105D05 Receptor FR848_10570 ENOG4105C4W S-formylglutathione hydrolase FR848_10575 ENOG4105EUJ GTP cyclohydrolase i FR848_10580 ENOG4105DHF Membrane FR848_10585 ENOG41060NJ transcriptional regulator FR848_10595 ENOG4105C2J ABC transporter FR848_10600 ENOG4107SDZ Galactoside transport system permease protein mglC FR848_10605 ENOG4107GZ4 SanA protein FR848_10610 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) FR848_10615 ENOG41067MG lrgb family FR848_10620 ENOG4105VAW lrga family FR848_10625 ENOG4106KR7 LysR family Transcriptional regulator FR848_10645 ENOG4108RXX maleylacetoacetate isomerase FR848_10650 ENOG4105MSY salicylate hydroxylase FR848_10655 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FR848_10670 ENOG4105CS2 ec 3.2.1.21 FR848_10675 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FR848_10685 ENOG4105KHU inner membrane protein YohD FR848_10690 ENOG41069YE inner membrane protein yohC FR848_10695 ENOG41061WM D-Alanyl-D-Alanine FR848_10705 ENOG4105CXG d-lactate dehydrogenase FR848_10710 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FR848_10715 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system FR848_10720 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component FR848_10725 ENOG4108IJ8 ABC transporter FR848_10730 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component FR848_10740 ENOG4108XDN Transcriptional regulator FR848_10745 ENOG4108HRK Histidine kinase FR848_10750 ENOG4108NEV two component transcriptional regulator, LytTR family FR848_10755 ENOG4108W15 Protein of unknown function (DUF1456) FR848_10760 ENOG4106GP0 (LipO)protein FR848_10765 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FR848_10770 ENOG4105D1F ATP-binding protein FR848_10780 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly FR848_10785 ENOG4105CBN LysR family transcriptional regulator FR848_10790 ENOG4105C7N Xanthine uracil vitamin C permease FR848_10795 ENOG4105CPN adenine deaminase FR848_10800 ENOG4105DUM transcriptional regulator, lysR family FR848_10810 ENOG4105EUZ Beta-lactamase domain protein FR848_10895 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FR848_10900 ENOG4105DWF phosphomethylpyrimidine kinase FR848_10905 ENOG4105EIE fructose-bisphosphate aldolase FR848_10930 ENOG4105DEI Mannitol dehydrogenase FR848_10935 ENOG4105CMG Carbohydrate kinase FR848_10940 ENOG4105IE8 Alpha-ketoglutarate permease FR848_10945 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FR848_10950 ENOG4105CXK mandelate racemase muconate lactonizing FR848_10955 ENOG4105DEF Extracellular solute-binding protein, family 5 FR848_10960 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FR848_10965 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FR848_10975 ENOG4108JQ7 (ABC) transporter FR848_10995 ENOG4105CFP Peptidase U32 FR848_11000 ENOG4105E3W Two component transcriptional regulator (Winged helix family FR848_11005 ENOG4105EB3 Histidine kinase FR848_11015 ENOG4105BZS acriflavin resistance protein FR848_11025 ENOG4105ENT Efflux transporter rnd family, mfp subunit FR848_11030 ENOG4106V2I dimethylaminohydrolase FR848_11035 ENOG4106PMH Extracellular solute-binding protein family 3 FR848_11040 ENOG4105DSP amino acid AbC transporter FR848_11050 ENOG4108RYR transcriptional regulator AsnC family FR848_11065 ENOG4105VJY transcriptional regulator FR848_11075 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FR848_11080 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FR848_11100 ENOG4105CK2 sodium dicarboxylate symporter FR848_11115 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FR848_11120 ENOG4105C08 Histidine kinase FR848_11125 ENOG4105BZN citrate synthase FR848_11130 ENOG4105R8A Heat shock protein FR848_11135 ENOG4105D03 DNA-3-methyladenine glycosylase II FR848_11150 ENOG4108GAE asmA family FR848_11155 ENOG4105EE5 Membrane protein terC FR848_11160 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FR848_11165 ENOG4105MH5 phosphoesterase PA-phosphatase related protein FR848_11175 ENOG4108MRJ FR848_11180 ENOG4105DAY polysaccharide export protein FR848_11195 ENOG4105D3Q Sugar transferase FR848_11220 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FR848_11245 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FR848_11310 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FR848_11315 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FR848_11325 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FR848_11330 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FR848_11335 ENOG4105CIH Imidazole acetol-phosphate transaminase FR848_11340 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FR848_11355 ENOG4108535 NAD dependent epimerase/dehydratase family FR848_11360 ENOG4105EQ1 Transcriptional regulator FR848_11370 ENOG4105CUB amino acid FR848_11385 ENOG4108JUA Transcriptional regulator FR848_11390 ENOG4105DS4 PAS PAC sensor Signal transduction histidine kinase FR848_11475 ENOG4105YVS arsR family transcriptional regulator FR848_11480 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FR848_11500 ENOG4105DZ1 carboxypeptidase FR848_11505 ENOG4108MRJ FR848_11515 ENOG4105DR8 Membrane FR848_11535 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FR848_11545 ENOG4107QNK )-transporter FR848_11550 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FR848_11555 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FR848_11560 ENOG4107QP6 Xylose isomerase domain protein TIM barrel FR848_11565 ENOG41060NJ transcriptional regulator FR848_11570 ENOG41090U3 tautomerase FR848_11575 ENOG4105HEI LysR family (Transcriptional regulator FR848_11580 ENOG4108KMH lipoate-protein ligase a FR848_11585 ENOG4105CSH Transporter FR848_11595 ENOG4105BZU Histidine kinase FR848_11600 ENOG4108YS1 cytoplasmic protein FR848_11605 ENOG4105YP6 Domain of unknown function (DUF1869) FR848_11610 ENOG4105FDP GntR family transcriptional regulator FR848_11615 ENOG4105CI1 PTS System FR848_11620 ENOG4105F8D glycoside hydrolase family 4 FR848_11630 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin FR848_11635 ENOG4108T65 Fimbrial FR848_11640 ENOG4108SQA Fimbrial FR848_11645 ENOG4105CW0 outer membrane usher protein FR848_11650 ENOG4108NAE Fimbrial chaperone protein FR848_11655 ENOG4108S54 Fimbrial protein FR848_11660 ENOG4108RQP Major type 1 subunit fimbrin FR848_11690 ENOG4107R11 Transcriptional regulator FR848_11695 ENOG4108PXI ErfK YbiS YcfS YnhG FR848_11710 ENOG4108FN7 Aldo keto reductase FR848_11715 ENOG410642W LysR family Transcriptional regulator FR848_11880 ENOG4105UQX Mate efflux family protein FR848_11895 ENOG4105FYV Amp nucleosidase FR848_11900 ENOG4106GZG polymyxin resistance protein B FR848_11925 ENOG4105BZS acriflavin resistance protein FR848_11930 ENOG4105ENT Efflux transporter rnd family, mfp subunit FR848_11935 ENOG4108U51 Universal stress protein FR848_11945 ENOG4105NIV Esterase FR848_11955 ENOG4105EQ2 LysR family Transcriptional regulator FR848_11965 ENOG4108UQ8 endoribonuclease L-psp FR848_11970 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FR848_11980 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) FR848_12005 ENOG4105ZIT Porin Gram-negative type FR848_12010 ENOG4105Y0K Inner membrane protein YedR FR848_12015 ENOG4105EST Metal Dependent Phosphohydrolase FR848_12020 ENOG4105DVF Cytosine-specific methyltransferase FR848_12025 ENOG41090BB DNA mismatch endonuclease (vsr) FR848_12030 ENOG4105FDR Membrane FR848_12035 ENOG4105CKW Inner membrane protein yedI FR848_12040 ENOG4105VNZ cytoplasmic protein FR848_12050 ENOG4105YX3 cellular response to acidity FR848_12065 ENOG4105JCU Inherit from NOG: (Lipo)protein FR848_12070 ENOG4105E5K Alpha-amylase FR848_12075 ENOG4105EAB amino acid AbC transporter FR848_12085 ENOG4105E5Q amino acid AbC transporter FR848_12090 ENOG4105CDA abc transporter atp-binding protein FR848_12095 ENOG4105VJY transcriptional regulator FR848_12100 ENOG4105XVG cytoplasmic protein FR848_12105 ENOG4105WH1 Two component transcriptional regulator luxr family FR848_12115 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FR848_12135 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FR848_12140 ENOG4106RHG Yeca family FR848_12145 ENOG4105E0U tyrosine-specific transport protein FR848_12150 ENOG4105VVZ metal-binding protein FR848_12155 ENOG41090A1 ferritin FR848_12165 ENOG4105C0R drug resistance transporter emrb qaca subfamily FR848_12175 ENOG4105N4N Protein of unknown function (DUF2766) FR848_12180 ENOG4105CT4 transporter FR848_12185 ENOG4108UEC Ferritin-like protein FR848_12195 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator FR848_12205 ENOG4105CNN ABC, transporter FR848_12210 ENOG4108K4C ec 3.1.3.12 FR848_12215 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase FR848_12220 ENOG4108VA4 Universal stress protein FR848_12230 ENOG4105CT4 transporter FR848_12235 ENOG4105F5H Glycosyl Hydrolase Family 88 FR848_12240 ENOG4105C75 arginyL-tRNA synthetase FR848_12245 ENOG4106ZCM YecM protein FR848_12255 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FR848_12265 ENOG4105WJG Glutathione FR848_12270 ENOG41081XQ Conserved Protein FR848_12275 ENOG4105D3W isochorismatase FR848_12280 ENOG4105C9M aspartyl-trna synthetase FR848_12285 ENOG4108TIT dATP pyrophosphohydrolase FR848_12290 ENOG4105CDY transcriptional regulatory protein FR848_12295 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FR848_12305 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FR848_12310 ENOG4105FAV ABC, transporter FR848_12315 ENOG4105FDK ABC transporter FR848_12320 ENOG4105NXV High-affinity zinc uptake system protein FR848_12325 ENOG4105DR5 peptidase FR848_12330 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FR848_12335 ENOG4108MRH transcriptional regulatory protein FR848_12340 ENOG4107R1I NAD-dependent malic enzyme FR848_12345 ENOG4107TT2 Auxin Efflux Carrier FR848_12355 ENOG4105CA9 Pyruvate kinase FR848_12360 ENOG4106KNT transcriptional regulator FR848_12365 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FR848_12370 ENOG4105C01 Dihydroxy-acid dehydratase FR848_12375 ENOG4108UHU Aldolase FR848_12385 ENOG4105X2V dna damage-inducible protein FR848_12390 ENOG4108Q2J Inner membrane protein YebE FR848_12395 ENOG4105CUG Oligopeptidase b FR848_12400 ENOG4105UMD exodeoxyribonuclease X FR848_12405 ENOG4105MPK DNA polymerase III subunit theta FR848_12410 ENOG4105FXM Copper resistance protein FR848_12415 ENOG4108PNC copper resistance FR848_12420 ENOG4105NKT exported protein FR848_12455 ENOG4108MJ5 VirK protein FR848_12460 ENOG4108R1E Serine threonine protein phosphatase 1 FR848_12465 ENOG4105UVW uncharacterized protein yebW FR848_12470 ENOG4105WT8 Protein of unknown function (DUF1480) FR848_12480 ENOG4105DY2 Paraquat-inducible protein b FR848_12485 ENOG4105H2K paraquat-inducible protein a FR848_12490 ENOG4108ZGC gaf domain protein FR848_12500 ENOG4105CN1 protease FR848_12505 ENOG4105D0M Protease HtpX homolog FR848_12510 ENOG4105C0R drug resistance transporter emrb qaca subfamily FR848_12515 ENOG4105J4Q Transcriptional regulator FR848_12520 ENOG4105TIK FR848_12530 ENOG4105Q3Y exported protein FR848_12535 ENOG410610J Protein of unknown function (DUF2627) FR848_12540 ENOG4105VEQ Cold shock protein FR848_12545 ENOG4105CJN penicillin-binding protein FR848_12550 ENOG4105DHI Methyltransferase FR848_12555 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) FR848_12565 ENOG4105F3R pts system mannose fructose sorbose family iid FR848_12570 ENOG4105ETZ PTS System FR848_12575 ENOG4108EQA pts system FR848_12580 ENOG4105EE5 Membrane protein terC FR848_12585 ENOG4107XTP (EAL) domain protein FR848_12590 ENOG4105EJQ L-serine dehydratase FR848_12605 ENOG4105X5C UPF0181 protein FR848_12610 ENOG4105EY3 heparinase II III family protein FR848_12620 ENOG4105E0S extracellular solute-binding protein family 1 FR848_12625 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FR848_12630 ENOG4105DRS transport system, permease FR848_12645 ENOG4105M4H endoribonuclease L-psp FR848_12650 ENOG4105DVT helicase FR848_12655 ENOG41072GX Peptidase M22 Glycoprotease FR848_12660 ENOG4105Y4Z Outer Membrane Lipoprotein FR848_12665 ENOG4105CEY Amp-dependent synthetase and ligase FR848_12670 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FR848_12675 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) FR848_12680 ENOG4107QMS site-determining protein FR848_12685 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FR848_12690 ENOG4105VNG YcgL domain-containing protein FR848_12695 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FR848_12715 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FR848_12720 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) FR848_12725 ENOG4108RS6 transposase FR848_12730 ENOG4105ED1 spovr family FR848_12745 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FR848_12750 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FR848_12755 ENOG4106JQ5 Transglycosylase SLT domain FR848_12765 ENOG4105CT4 transporter FR848_12825 ENOG4105CPU Monooxygenase FR848_12835 ENOG4105E90 ABC transporter FR848_12840 ENOG4105E90 ABC transporter FR848_12845 ENOG4108IJ8 ABC transporter FR848_12850 ENOG4105D3G Pseudouridine synthase FR848_12855 ENOG4107YNJ LysR family Transcriptional regulator FR848_12875 ENOG4105VT2 5-hydroxyisourate hydrolase FR848_12880 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FR848_12885 ENOG4105C54 Major Facilitator superfamily FR848_12900 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase FR848_12910 ENOG4105C2W permease FR848_12915 ENOG4105BZ8 glutamate synthase FR848_12920 ENOG4108R8B oxidoreductase Fe-S subunit FR848_12925 ENOG4107UUR Chlorohydrolase aminohydrolase FR848_12930 ENOG4105BZ8 glutamate synthase FR848_12935 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family FR848_12940 ENOG4105C5B carbamate kinase FR848_12950 ENOG4107S4Y M20 DapE family protein YgeY FR848_12955 ENOG4107RCH Diaminopropionate ammonia-lyase FR848_12960 ENOG4105IW6 Carbamoyltransferase FR848_12970 ENOG4108JUB Transcriptional regulator FR848_12975 ENOG4105MZU cell filamentation protein FR848_12980 ENOG4105DFP Integrase FR848_12985 ENOG4105C3G gtp-binding protein FR848_12995 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria FR848_13005 ENOG4105CHH sulfate transporter FR848_13010 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FR848_13015 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FR848_13035 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FR848_13040 ENOG4108YY7 Invasion gene expression up-regulator SirB FR848_13045 ENOG41063JG Transcriptional regulator FR848_13055 ENOG4105EWV Sodium calcium exchanger membrane region FR848_13060 ENOG4105WS7 Cation transport regulator FR848_13065 ENOG4108NH8 Cation transport protein FR848_13075 ENOG41090EX DsrE family FR848_13095 ENOG4105D7T ABC transporter FR848_13100 ENOG4107QZF nitrite reductase NADPH large subunit FR848_13110 ENOG4105ID0 Putative invasin FR848_13115 ENOG4105WH1 Two component transcriptional regulator luxr family FR848_13120 ENOG4105BZU Histidine kinase FR848_13125 ENOG4105DQQ Major facilitator superfamily MFS_1 FR848_13130 ENOG4105CRU nitrate reductase, alpha subunit FR848_13135 ENOG4108IUE nitrate reductase beta subunit FR848_13140 ENOG4105R3A Nitrate reductase FR848_13145 ENOG41076YT nitrate reductase, gamma subunit FR848_13175 ENOG4105CIY formyltetrahydrofolate deformylase FR848_13185 ENOG4105D78 K07001 NTE family protein FR848_13190 ENOG4105I93 response regulator FR848_13195 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FR848_13200 ENOG4108SAU DNA-binding protein H-ns FR848_13215 ENOG4108EKI Dehydrogenase FR848_13220 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FR848_13230 ENOG4107QSI ABC, transporter FR848_13240 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FR848_13245 ENOG4105C3U ABC transporter FR848_13250 ENOG4108JQ7 (ABC) transporter FR848_13255 ENOG4105EYW Ion transport protein FR848_13265 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FR848_13275 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FR848_13280 ENOG4105K9H YciI-like protein FR848_13285 ENOG410822N TonB family FR848_13290 ENOG4105FGM Fructosamine kinase FR848_13295 ENOG4105P10 Uncharacterized protein ydiZ FR848_13300 ENOG4105DE4 1-phosphofructokinase FR848_13305 ENOG4108NE3 Salt-induced outer membrane protein FR848_13325 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FR848_13330 ENOG41082NX 50s ribosomal protein l35 FR848_13335 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FR848_13355 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FR848_13365 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) FR848_13370 ENOG4105D01 (LipO)protein FR848_13375 ENOG4108V06 Glutathione peroxidase FR848_13380 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) FR848_13385 ENOG4108QBX (LipO)protein FR848_13395 ENOG4106EDX Hemin uptake protein FR848_13400 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FR848_13410 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FR848_13420 ENOG4105IPI Membrane FR848_13425 ENOG4105CQB FAD linked oxidase domain protein FR848_13430 ENOG4105KA0 thioesterase Superfamily protein FR848_13435 ENOG4105Y3U Transglycosylase-associated protein FR848_13440 ENOG4108PNB DNA-binding transcriptional regulator FR848_13445 ENOG4108PNB DNA-binding transcriptional regulator FR848_13450 ENOG4108RQP Major type 1 subunit fimbrin FR848_13455 ENOG4108VCD Chaperone FR848_13460 ENOG4105CW0 outer membrane usher protein FR848_13470 ENOG4108T65 Fimbrial FR848_13480 ENOG4108Z4V iron-sulfur cluster assembly FR848_13485 ENOG4105DIW FeS assembly protein SUFB FR848_13490 ENOG4105C3K feS assembly ATPase SufC FR848_13495 ENOG4105JRK feS assembly protein SufD FR848_13505 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FR848_13510 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FR848_13520 ENOG4105CA9 Pyruvate kinase FR848_13525 ENOG4105RFR Protein of unknown function (DUF2767) FR848_13540 ENOG4105DJB Major Facilitator Superfamily FR848_13545 ENOG4107V59 shikimate FR848_13550 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein FR848_13555 ENOG4108W0P ABC transporter FR848_13560 ENOG4105EHG Permease protein FR848_13565 ENOG4105S10 periplasmic binding protein FR848_13570 ENOG4108K2P TRANSCRIPTIONal FR848_13590 ENOG4105IKQ hydratase FR848_13605 ENOG4108SC4 )-transporter FR848_13625 ENOG4108T2C cysteine dioxygenase type I FR848_13630 ENOG4105W7K Transcriptional regulator FR848_13635 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FR848_13640 ENOG4105FDT acyl-CoA dehydrogenase FR848_13655 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FR848_13660 ENOG4105E2Y ABC, transporter FR848_13670 ENOG4105E0A ABC, transporter FR848_13675 ENOG4105DQ5 transport system permease protein FR848_13695 ENOG4106PMH Extracellular solute-binding protein family 3 FR848_13700 ENOG4105E5Q amino acid AbC transporter FR848_13705 ENOG4105CDA abc transporter atp-binding protein FR848_13715 ENOG4105CH2 amidohydrolase FR848_13720 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FR848_13725 ENOG4105DG4 malate L-lactate dehydrogenase FR848_13750 ENOG4107XSU flagellar motor protein motb FR848_13865 ENOG4107Z33 ABC transporter, permease FR848_13870 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FR848_13875 ENOG4105CHR reductase FR848_13880 ENOG4105C7K acetolactate synthase FR848_13895 ENOG41060EU Cold shock-like protein FR848_13925 ENOG4108W9T type 1 fimbriae regulatory protein FR848_13930 ENOG4108T65 Fimbrial FR848_13940 ENOG4105CW0 outer membrane usher protein FR848_13945 ENOG4108VCD Chaperone FR848_13955 ENOG4108W9T type 1 fimbriae regulatory protein FR848_13960 ENOG4105DZG Dehydrogenase FR848_13965 ENOG4108JQ7 (ABC) transporter FR848_13985 ENOG4105DIB Oligopeptide-binding protein FR848_13995 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FR848_14000 ENOG4105MVE transcriptional regulator FR848_14010 ENOG4107B2H carbonic anhydrase FR848_14020 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FR848_14025 ENOG4108YDI single-species biofilm formation on inanimate substrate FR848_14030 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain FR848_14045 ENOG4108QY0 Membrane FR848_14050 ENOG4108WTK competence damage-inducible protein FR848_14065 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FR848_14070 ENOG4105C4M (Ubiquinol oxidase) subunit I FR848_14075 ENOG4105WEF catalase FR848_14080 ENOG4108N8X transition metal ion binding FR848_14085 ENOG4108Z9Z response to DNA damage stimulus FR848_14110 ENOG4107QI1 Mate efflux family protein FR848_14115 ENOG4108R6K riboflavin synthase, subunit alpha FR848_14120 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FR848_14125 ENOG4105CZQ inner membrane transport protein YdhC FR848_14130 ENOG4105F52 Transcriptional regulator FR848_14145 ENOG4105F27 Major Facilitator FR848_14150 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FR848_14155 ENOG4105K4H Nlp p60 protein FR848_14160 ENOG4105M2J Glutaredoxin FR848_14165 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FR848_14170 ENOG4108UYE Lactoylglutathione lyase FR848_14175 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FR848_14180 ENOG4108WUH Transcriptional regulator, TetR family FR848_14185 ENOG4105XZD Fe-S protein FR848_14190 ENOG4107RGM aldo keto reductase FR848_14195 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FR848_14205 ENOG4105Y49 secretion protein, HlyD family FR848_14220 ENOG4105BZU Histidine kinase FR848_14225 ENOG4108XTF Outer Membrane Lipoprotein FR848_14230 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FR848_14235 ENOG410642K Lysozyme inhibitor FR848_14240 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FR848_14245 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FR848_14255 ENOG4108K3A Glutathione S-transferase FR848_14260 ENOG4105DUX Transporter FR848_14265 ENOG4105CSM endonuclease III FR848_14275 ENOG4108UQQ Electron transport complex FR848_14300 ENOG4105M9B inner membrane protein ydgK FR848_14310 ENOG4105CS2 ec 3.2.1.21 FR848_14320 ENOG4105D9R oxidoreductase FR848_14330 ENOG4105D01 (LipO)protein FR848_14335 ENOG4105KSU Redox protein FR848_14340 ENOG41066VF YeeE YedE family protein FR848_14345 ENOG41061EV selenium-binding protein YdfZ FR848_14350 ENOG4105C87 Aminotransferase class I and II FR848_14355 ENOG4105CI1 PTS System FR848_14360 ENOG4107P2S Transcriptional regulator FR848_14365 ENOG4106J39 exported protein FR848_14370 ENOG4105EIP mannose-6-phosphate isomerase FR848_14375 ENOG4107GFK fumarate FR848_14380 ENOG4105C9Q fumarate hydratase class II FR848_14390 ENOG4105JJR Histidine kinase FR848_14405 ENOG4108V06 Glutathione peroxidase FR848_14410 ENOG4105BZU Histidine kinase FR848_14415 ENOG4107EXC regulatoR FR848_14430 ENOG4105RA2 Membrane FR848_14435 ENOG410642E Short chain dehydrogenase FR848_14440 ENOG4105D5Q Arginine ornithine antiporter FR848_14445 ENOG4105C5D exported protein FR848_14455 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FR848_14460 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FR848_14465 ENOG410671Z uncharacterized protein ydiH FR848_14470 ENOG4105Q9Y Universal stress protein FR848_14475 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FR848_14480 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FR848_14485 ENOG4105CFC Transporter FR848_14490 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B FR848_14500 ENOG4106KR7 LysR family Transcriptional regulator FR848_14505 ENOG4108DG9 Smr protein MutS2 FR848_14510 ENOG4107HP6 Transcriptional regulator FR848_14520 ENOG4107QNJ CoA-transferase subunit B FR848_14525 ENOG4105CHU acetyl-coa acetyltransferase FR848_14530 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FR848_14535 ENOG4105F2Z 3-oxoadipate enol-lactonase FR848_14540 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FR848_14545 ENOG4107GFK fumarate FR848_14565 ENOG4108MRH transcriptional regulatory protein FR848_14570 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FR848_14575 ENOG4105EQ2 LysR family Transcriptional regulator FR848_14580 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FR848_14585 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FR848_14590 ENOG4105DWT malate dehydrogenase (quinone) FR848_14595 ENOG4108K70 Transcriptional regulator FR848_14600 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FR848_14605 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase FR848_14610 ENOG4107TT2 Auxin Efflux Carrier FR848_14640 ENOG4105DSF transport protein FR848_14650 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) FR848_14660 ENOG4105BZU Histidine kinase FR848_14665 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap FR848_14685 ENOG4105CTD carboxy-peptidase FR848_14690 ENOG4105D94 Major Facilitator Superfamily FR848_14695 ENOG4106NZI LysR family Transcriptional regulator FR848_14700 ENOG4105DAG ROK family FR848_14705 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FR848_14710 ENOG4105CMQ Chloride channel FR848_14715 ENOG4108NEM leader-binding protein dmsD FR848_14720 ENOG4107KGK dmso reductase anchor subunit FR848_14725 ENOG4105QAX Iron-sulfur FR848_14730 ENOG4107QY8 reductase FR848_14735 ENOG4105KBG Protein of unknown function (DUF1161) FR848_14745 ENOG4108MK9 spermidine N(1)-acetyltransferase FR848_14750 ENOG4105M5Q UPF0482 protein FR848_14760 ENOG4105CXK mandelate racemase muconate lactonizing FR848_14765 ENOG4105CPQ Dehydrogenase FR848_14775 ENOG4105DEI Mannitol dehydrogenase FR848_14780 ENOG4108U51 Universal stress protein FR848_14785 ENOG4107XBN GntR Family Transcriptional Regulator FR848_14790 ENOG4105EMU Dehydrogenase FR848_14795 ENOG4105DGW oligopeptidase A FR848_14810 ENOG4105DGW oligopeptidase A FR848_14830 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FR848_14855 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FR848_14860 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FR848_14865 ENOG4105CNT hydrolase family 2 FR848_14870 ENOG4105ETE Transcriptional regulator (LacI family FR848_14880 ENOG4105BZU Histidine kinase FR848_14900 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FR848_14935 ENOG4105C32 Amino acid ABC transporter (Permease) FR848_14940 ENOG4105CNN ABC, transporter FR848_14945 ENOG4105C0Z ABC transporter FR848_14950 ENOG4108IV0 ABC, transporter FR848_14965 ENOG4105E5W Transporter FR848_14970 ENOG4108594 Permease of the drug metabolite transporter FR848_14975 ENOG4106DNR multiple antibiotic resistance protein FR848_14985 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FR848_14995 ENOG4105F27 Major Facilitator FR848_15000 ENOG4105JAB phenazine biosynthesis protein, phzf family FR848_15005 ENOG4105JAB phenazine biosynthesis protein, phzf family FR848_15010 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FR848_15020 ENOG4105EGI Transcriptional regulator FR848_15025 ENOG4105C26 Dehydrogenase FR848_15035 ENOG4105M0C cytoplasmic protein FR848_15040 ENOG4105BZU Histidine kinase FR848_15090 ENOG4105EP1 Efflux transporter rnd family, mfp subunit FR848_15095 ENOG4108IJF Heavy metal efflux pump, CzcA FR848_15105 ENOG4105F9N Major Facilitator Superfamily FR848_15125 ENOG410829K Lysine exporter protein (Lyse ygga) FR848_15135 ENOG4105CBP Major Facilitator FR848_15140 ENOG4105EGI Transcriptional regulator FR848_15150 ENOG4108UMI ABC transporter, permease FR848_15160 ENOG4105D01 (LipO)protein FR848_15170 ENOG4105VYA Uncharacterized conserved protein (DUF2132) FR848_15175 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction FR848_15185 ENOG4105E5Q amino acid AbC transporter FR848_15210 ENOG4105II7 pyrroline-5-carboxylate reductase FR848_15215 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions FR848_15225 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FR848_15235 ENOG4105CK1 PTS System FR848_15250 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FR848_15255 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FR848_15260 ENOG4105EHG Permease protein FR848_15275 ENOG4105FCK Membrane FR848_15280 ENOG4105DT3 PTS system, galactitol-specific IIc component FR848_15285 ENOG4108M3J Dehydrogenase FR848_15290 ENOG4105CHR reductase FR848_15295 ENOG4105CMG Carbohydrate kinase FR848_15305 ENOG41061GT Aldolase FR848_15320 ENOG4105CNN ABC, transporter FR848_15325 ENOG4105C2J ABC transporter FR848_15330 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FR848_15335 ENOG4105ETE Transcriptional regulator (LacI family FR848_15340 ENOG4105KZM cytoplasmic protein FR848_15345 ENOG4108V4B ThiJ pfpI FR848_15365 ENOG410642W LysR family Transcriptional regulator FR848_15390 ENOG4105Z2P Protein of unknown function (DUF465) FR848_15425 ENOG4106ETB IIa component FR848_15440 ENOG4108SU4 UPF0309 protein FR848_15485 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FR848_15490 ENOG4105CJP fad dependent oxidoreductase FR848_15495 ENOG4105DB1 molybdopterin oxidoreductase FR848_15500 ENOG4106WHD Tetrathionate reductase FR848_15505 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FR848_15510 ENOG4106AFQ Histidine kinase FR848_15515 ENOG4108ZXC Two component transcriptional regulator, luxr family FR848_15520 ENOG4108NS2 receptor FR848_15525 ENOG4105D05 Receptor FR848_15535 ENOG4107PP3 Acetylornithine deacetylase FR848_15550 ENOG4105CNN ABC, transporter FR848_15555 ENOG4105C2J ABC transporter FR848_15560 ENOG4105ETE Transcriptional regulator (LacI family FR848_15590 ENOG4109066 lysm domain bon superfamily protein FR848_15595 ENOG4107ZSV Receptor FR848_15600 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FR848_15620 ENOG4105C0W non-ribosomal peptide synthetase FR848_15635 ENOG4105BZ1 (ABC) transporter FR848_15640 ENOG4105EYM Major Facilitator superfamily FR848_15650 ENOG4105CXY transporter FR848_15655 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC FR848_15665 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta FR848_15670 ENOG4105C44 Serine transporter FR848_15675 ENOG4105EJQ L-serine dehydratase FR848_15775 ENOG4107R0V Pyruvate dehydrogenase FR848_15780 ENOG4105CPP Dehydrogenase, E1 component FR848_15805 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FR848_15815 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FR848_15825 ENOG4105VPI YqaE family transport protein FR848_15830 ENOG4108WN0 inhibitor of vertebrate lysozyme FR848_15835 ENOG4106MMI NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FR848_15840 ENOG4105BZU Histidine kinase FR848_15845 ENOG4105F32 YngK protein FR848_15880 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FR848_15885 ENOG4105CIB oxidoreductase Domain protein FR848_15890 ENOG4105ETU transcriptional activator (TenA FR848_15895 ENOG4108YI8 ABC transporter FR848_15900 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component FR848_15905 ENOG4107Z6I Thiamine biosynthesis protein FR848_15910 ENOG4108JPW Aminotransferase FR848_15915 ENOG4105DY8 decarboxylase FR848_15930 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FR848_15945 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FR848_15960 ENOG4105D7T ABC transporter FR848_15985 ENOG4105E82 cytochrome subunit of dehydrogenase FR848_16005 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FR848_16015 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FR848_16030 ENOG4107TE1 transport protein FR848_16040 ENOG4105CR8 Transcriptional regulator FR848_16045 ENOG4107RSM transcriptional regulator FR848_16055 ENOG4108NIW Leucine export protein LeuE FR848_16060 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FR848_16065 ENOG4105FFC UPF0187 protein FR848_16080 ENOG4108Z9K Osmotically inducible protein FR848_16090 ENOG4105JQN Transcriptional regulator FR848_16110 ENOG4105C5H ABC transporter FR848_16135 ENOG4105DQ4 alcohol dehydrogenase FR848_16155 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FR848_16175 ENOG4105F27 Major Facilitator FR848_16190 ENOG4108MG3 formate dehydrogenase FR848_16195 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FR848_16205 ENOG4105RPH Inner membrane protein YddG FR848_16220 ENOG4107QND Nitrite extrusion protein FR848_16225 ENOG4105CRU nitrate reductase, alpha subunit FR848_16230 ENOG4108IUE nitrate reductase beta subunit FR848_16235 ENOG4108NZN Respiratory nitrate reductase 2 delta chain FR848_16240 ENOG4105D0D Nitrate reductase 2, gamma subunit FR848_16245 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FR848_16250 ENOG4107RCV ABC transporter, permease FR848_16255 ENOG4105C4Y ABC transporter FR848_16265 ENOG4108MEJ flavin reductase domain protein FR848_16270 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) FR848_16280 ENOG4105CT4 transporter FR848_16305 ENOG4108N27 Glutathione S-transferase FR848_16310 ENOG4105ETE Transcriptional regulator (LacI family FR848_16315 ENOG4105DIA mandelate racemase muconate lactonizing FR848_16320 ENOG4105DJB Major Facilitator Superfamily FR848_16330 ENOG4105CDA abc transporter atp-binding protein FR848_16345 ENOG4105EAB amino acid AbC transporter FR848_16355 ENOG4105CH2 amidohydrolase FR848_16360 ENOG4105DEN Luciferase family FR848_16370 ENOG4105CAT Cytidine monophosphate kinase FR848_16375 ENOG4105C85 amino acid FR848_16380 ENOG4105SUV lipoprotein YgdR FR848_16385 ENOG4108NS2 receptor FR848_16390 ENOG4105CHB tonB-dependent Receptor FR848_16395 ENOG41065TG regulatoR FR848_16410 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FR848_16425 ENOG4108Z7F N-acetyltransferase FR848_16430 ENOG4108T9Y Inner membrane protein ydcZ FR848_16435 ENOG4105R71 cytoplasmic protein FR848_16440 ENOG4105DEF Extracellular solute-binding protein, family 5 FR848_16450 ENOG4105NBR Pectinesterase FR848_16455 ENOG4105EBM Alpha Beta Hydrolase Fold protein FR848_16460 ENOG410654E Membrane FR848_16480 ENOG4105C26 Dehydrogenase FR848_16485 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component FR848_16490 ENOG4105D81 ABC transporter, permease FR848_16495 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FR848_16500 ENOG4107TYH extracellular solute-binding protein family 1 FR848_16510 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FR848_16515 ENOG4105C4M (Ubiquinol oxidase) subunit I FR848_16520 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FR848_16535 ENOG4105CFP Peptidase U32 FR848_16540 ENOG4108JCI Transcriptional regulator FR848_16545 ENOG4105DKK Benzoate FR848_16550 ENOG4108W3Q Transcriptional regulator FR848_16555 ENOG4108RNG Permease of the drug metabolite transporter FR848_16560 ENOG4108KKZ (LipO)protein FR848_16565 ENOG4105DEF Extracellular solute-binding protein, family 5 FR848_16570 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FR848_16575 ENOG41088CC tellurite resistance protein tehB FR848_16580 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein FR848_16585 ENOG4107WE3 acetyltransferase YdcK FR848_16590 ENOG4108Z9I -acetyltransferase FR848_16600 ENOG4105EBR Carboxylesterase FR848_16605 ENOG4105E32 cytoplasmic protein FR848_16610 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta FR848_16615 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha FR848_16620 ENOG4105DDW LysR family Transcriptional regulator FR848_16650 ENOG4105CPW cytochrome b561 FR848_16655 ENOG4105Y50 Virulence Protein FR848_16665 ENOG41061EV selenium-binding protein YdfZ FR848_16670 ENOG4105BZU Histidine kinase FR848_16675 ENOG4105W8I Transcriptional regulator FR848_16680 ENOG4105KD7 acetyltransferase FR848_16685 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FR848_16690 ENOG4105C26 Dehydrogenase FR848_16695 ENOG4107DB1 DUF218 domain FR848_16705 ENOG4105D82 Glutamate dehydrogenase FR848_16725 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FR848_16735 ENOG4105CQ7 ATP-dependent helicase FR848_16740 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FR848_16750 ENOG4108Z0R Transferase FR848_16755 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FR848_16760 ENOG4105DZS Phenylacetate-CoA ligase FR848_16765 ENOG4105CHU acetyl-coa acetyltransferase FR848_16770 ENOG4108ZJI phenylacetic acid degradation protein FR848_16775 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FR848_16780 ENOG4108UKI Enoyl-CoA hydratase FR848_16785 ENOG4105E39 Enoyl-CoA hydratase FR848_16790 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FR848_16795 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FR848_16800 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FR848_16805 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FR848_16810 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FR848_16815 ENOG4105DXM phenylacetic acid degradation protein FR848_16820 ENOG4105F11 amine oxidase FR848_16835 ENOG4105XDF Protein of unknown function (DUF1272) FR848_16850 ENOG4105HEI LysR family (Transcriptional regulator FR848_16860 ENOG4105ECQ AraC Family Transcriptional Regulator FR848_16875 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FR848_16880 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FR848_16900 ENOG4105CHR reductase FR848_16905 ENOG4105D29 Helix-turn-helix type 11 domain protein FR848_16910 ENOG4105CVJ phosphoglycerate mutase FR848_16925 ENOG4105C1P efflux transporter, rnd family, mfp subunit FR848_16930 ENOG4105UEI Transcriptional Regulator AraC Family FR848_16935 ENOG4105R1U AraC Family Transcriptional Regulator FR848_16940 ENOG4105DSW Fusaric acid resistance protein FR848_16950 ENOG4105Y49 secretion protein, HlyD family FR848_16970 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FR848_16975 ENOG4105NAE bifunctional deaminase-reductase domain protein FR848_17000 ENOG4105KME endoribonuclease L-psp FR848_17005 ENOG4105H3G oxidoreductase FR848_17010 ENOG4107R11 Transcriptional regulator FR848_17020 ENOG4105EV8 ectoine hydroxylase FR848_17030 ENOG4105MP9 class II Aldolase FR848_17035 ENOG4105C26 Dehydrogenase FR848_17040 ENOG4108WFR AraC Family Transcriptional Regulator FR848_17045 ENOG4105WXT Conserved Protein FR848_17050 ENOG410689M (LipO)protein FR848_17055 ENOG4107H52 Dicarboxylate transport FR848_17060 ENOG4108KF1 Membrane FR848_17065 ENOG4105C5I Dehydrogenase FR848_17070 ENOG41090X5 Heat shock protein hslJ FR848_17155 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) FR848_17165 ENOG4105FCK Membrane FR848_17175 ENOG4108RW8 Universal stress protein F FR848_17180 ENOG4105QYK bacteriophage lambda Bor protein homolog FR848_17200 ENOG4105C1J atp-dependent rna helicase FR848_17215 ENOG4105MVE transcriptional regulator FR848_17220 ENOG4105D9R oxidoreductase FR848_17225 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FR848_17230 ENOG4105KT5 UmuD protein FR848_17250 ENOG4105R3P Inner membrane protein yagU FR848_17260 ENOG4108PNB DNA-binding transcriptional regulator FR848_17275 ENOG4105E1F short-chain dehydrogenase reductase FR848_17285 ENOG4105CBN LysR family transcriptional regulator FR848_17290 ENOG4105EQ2 LysR family Transcriptional regulator FR848_17295 ENOG4105ENX hydrolase FR848_17300 ENOG4107RTG Major Facilitator superfamily FR848_17310 ENOG4108XDN Transcriptional regulator FR848_17320 ENOG4107FW0 short-chain dehydrogenase reductase FR848_17335 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FR848_17345 ENOG4107SEY Conserved Protein FR848_17350 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FR848_17355 ENOG4105CT4 transporter FR848_17360 ENOG4105DSG hydrolase family 43 FR848_17415 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FR848_17425 ENOG4105CDV Ompa motb domain protein FR848_17455 ENOG4108Z0Z intracellular protease Pfpi family FR848_17460 ENOG4108IY8 ABC, transporter FR848_17465 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FR848_17480 ENOG4105K6H D-cysteine desulfhydrase FR848_17485 ENOG4105DG4 malate L-lactate dehydrogenase FR848_17500 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FR848_17505 ENOG4105C9B Cysteine desulfurase FR848_17510 ENOG4105ESN nucleotide-binding protein FR848_17530 ENOG4105C6T cysteine synthase FR848_17535 ENOG4105D7W serine acetyltransferase FR848_17545 ENOG4105E5Q amino acid AbC transporter FR848_17550 ENOG4105CDA abc transporter atp-binding protein FR848_17555 ENOG4105EAB amino acid AbC transporter FR848_17560 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) FR848_17570 ENOG4105DRP amino acid AbC transporter FR848_17575 ENOG4108HW4 amino acid AbC transporter FR848_17595 ENOG4105CHM Aminotransferase FR848_17600 ENOG4105E7W lamb ycsf family protein FR848_17605 ENOG4107R7A Allophanate hydrolase subunit 2 FR848_17610 ENOG4105P4J Allophanate hydrolase, subunit 1 FR848_17615 ENOG4105F87 Dehydratase FR848_17620 ENOG4105DFI Membrane FR848_17625 ENOG4105D82 Glutamate dehydrogenase FR848_17630 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FR848_17635 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FR848_17640 ENOG4105FDP GntR family transcriptional regulator FR848_17655 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FR848_17675 ENOG4105D01 (LipO)protein FR848_17680 ENOG4108UMI ABC transporter, permease FR848_17695 ENOG4107QSI ABC, transporter FR848_17700 ENOG4105KXI murein peptide amidase A FR848_17705 ENOG4107S8C mandelate racemase muconate lactonizing FR848_17710 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FR848_17715 ENOG4108KK1 membrane protein AbrB duplication FR848_17720 ENOG4108JU8 Transcriptional regulator FR848_17730 ENOG4105CM6 amino acid regulated cytosolic protein FR848_17735 ENOG4105K8Z Phage shock protein FR848_17740 ENOG4105NNG Peripheral inner membrane phage-shock protein FR848_17745 ENOG4105FM1 phage shock protein C FR848_17750 ENOG4105YYT phage shock protein B FR848_17755 ENOG41087YS Phage shock protein A FR848_17760 ENOG4105E51 psp operon transcriptional activator FR848_17770 ENOG4105CH2 amidohydrolase FR848_17785 ENOG4108HIY periplasmic FR848_17790 ENOG4108I5W peptide transport system, permease protein FR848_17795 ENOG4108EU3 peptide transport system, permease FR848_17800 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein FR848_17805 ENOG4108JQ2 peptide transport system atp-binding protein FR848_17810 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FR848_17815 ENOG4105Q4T oxidoreductase FR848_17820 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) FR848_17830 ENOG4105N2W Transcriptional regulator FR848_17835 ENOG41061RM osmotically inducible lipoprotein FR848_17840 ENOG4108ZJT translation initiation factor, Sui1 FR848_17850 ENOG4105CFV Tetratricopeptide repeat protein FR848_17855 ENOG4105Q4A inner membrane protein yciS FR848_17860 ENOG4105EYK Phosphatidylglycerophosphatase B FR848_17870 ENOG4107QM5 aconitate hydratase FR848_17880 ENOG4107R11 Transcriptional regulator FR848_17885 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FR848_17890 ENOG4105RKX Protein of unknown function (DUF2498) FR848_17895 ENOG4105ERU peptidase FR848_17905 ENOG4105UBK short-chain dehydrogenase reductase FR848_17910 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FR848_17915 ENOG41075H3 AraC family transcriptional regulator FR848_17920 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FR848_17925 ENOG4105CT4 transporter FR848_17930 ENOG4105FE9 pseudouridine synthase FR848_17935 ENOG4107RTD sua5 ycio yrdc ywlc family protein FR848_17940 ENOG4105DB7 PHP domain protein FR848_17945 ENOG4105CRQ synthase (Component I) FR848_17950 ENOG4108EFP Anthranilate synthase component II FR848_17955 ENOG4105DK0 Indole-3-glycerol phosphate synthase FR848_17975 ENOG4105CPQ Dehydrogenase FR848_18000 ENOG4105N0E Protein of unknown function (DUF2543) FR848_18005 ENOG4105EIF outer membrane protein W FR848_18015 ENOG4107835 probably involved in intracellular septation (By similarity) FR848_18020 ENOG4107R4J Chloride channel FR848_18025 ENOG4107RNH Outer membrane receptor FepA FR848_18030 ENOG4105NAU thioesterase Superfamily protein FR848_18035 ENOG4107PN8 YfeABCD locus regulator FR848_18040 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FR848_18045 ENOG4105CHR reductase FR848_18050 ENOG4107K5X Membrane-bound metal-dependent hydrolase FR848_18055 ENOG4108ETY sodium dicarboxylate symporter FR848_18060 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) FR848_18065 ENOG4105CH6 catalase FR848_18070 ENOG410901P UPF0249 protein FR848_18075 ENOG4105F8D glycoside hydrolase family 4 FR848_18080 ENOG4105EZV Transcriptional regulator FR848_18085 ENOG4105VCP PTS System FR848_18090 ENOG4105CK1 PTS System FR848_18095 ENOG4105VZJ PTS System FR848_18100 ENOG4105KKI DNA-binding transcriptional activator OsmE FR848_18110 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) FR848_18115 ENOG4105EG3 transmembrane signal peptide protein FR848_18120 ENOG4108V0P LemA family FR848_18125 ENOG4108SPG Periplasmic Protein FR848_18135 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) FR848_18140 ENOG4105C26 Dehydrogenase FR848_18145 ENOG4105F4X arginine FR848_18155 ENOG4105CGK Exodeoxyribonuclease III FR848_18160 ENOG4108RSN SNARE associated Golgi FR848_18165 ENOG4108N5C SNARE associated Golgi protein-related protein FR848_18170 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FR848_18175 ENOG4105VNH ABC transporter solute-binding protein FR848_18180 ENOG4105CXZ ABC transporter, permease FR848_18185 ENOG4108VGW abc transporter atp-binding protein FR848_18190 ENOG4107RM6 sulfurtransferase FR848_18195 ENOG4108T9J Cdp-alcohol phosphatidyltransferase FR848_18200 ENOG4105M6F mutator MutT protein FR848_18205 ENOG4105D82 Glutamate dehydrogenase FR848_18210 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FR848_18215 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) FR848_18225 ENOG4105SBG acid phosphatase FR848_18230 ENOG41069NU Nitroreductase FR848_18235 ENOG4105D07 Signal peptide peptidase, SppA FR848_18240 ENOG4105HDK L-asparaginase FR848_18245 ENOG4108RWI nicotinamidase FR848_18250 ENOG4108KUU Inner membrane metabolite transport protein ydjE FR848_18255 ENOG4105E98 transcriptional regulator DeoR family FR848_18260 ENOG4105CPC Aldo Keto reductase FR848_18265 ENOG4107UH8 sugar kinase FR848_18270 ENOG4105D2N Aldolase FR848_18275 ENOG4105CPQ Dehydrogenase FR848_18280 ENOG4107TE1 transport protein FR848_18285 ENOG4105CPQ Dehydrogenase FR848_18295 ENOG4105N1F Hnh endonuclease FR848_18300 ENOG4105VUT cytoplasmic protein FR848_18310 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FR848_18315 ENOG4105DSB aldose 1-epimerase FR848_18320 ENOG4105CV8 reductase FR848_18325 ENOG4105GNX MltA-interacting MipA family protein FR848_18330 ENOG4105CYN Serine protein kinase FR848_18340 ENOG4108XNZ glycosyl transferase FR848_18350 ENOG4108KHP Diguanylate cyclase FR848_18355 ENOG4108KXH Ybak prolyl-tRNA synthetase associated FR848_18360 ENOG4108VMM UPF0756 membrane protein FR848_18365 ENOG4105R1U AraC Family Transcriptional Regulator FR848_18370 ENOG4105DJ2 Major Facilitator Superfamily FR848_18375 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FR848_18380 ENOG4105EWC Purine nucleoside phosphorylase FR848_18385 ENOG4105K78 MarR family Transcriptional regulator FR848_18390 ENOG4105UCG Domain of unknown function (DUF333) FR848_18395 ENOG410620I Diguanylate cyclase FR848_18400 ENOG4106G4W FR848_18415 ENOG4105S5I Membrane FR848_18420 ENOG4108NIW Leucine export protein LeuE FR848_18425 ENOG4105D1S lipid A biosynthesis FR848_18430 ENOG4105DVA methyltransferase FR848_18435 ENOG4108SF5 RNA Polymerase FR848_18440 ENOG4108S3W Anti-feci sigma factor, fecr FR848_18445 ENOG4105GAV receptor FR848_18450 ENOG4108HUF Transporter FR848_18455 ENOG4105DQ5 transport system permease protein FR848_18460 ENOG4108IHU transport system permease protein FR848_18465 ENOG4105E0A ABC, transporter FR848_18475 ENOG4105DHT Metal Dependent Phosphohydrolase FR848_18480 ENOG4106TD9 Diguanylate cyclase FR848_18485 ENOG4108RS6 transposase FR848_18490 ENOG4108HMX isocitrate dehydrogenase (NADP) FR848_18495 ENOG4108R99 pseudouridine synthase FR848_18515 ENOG4107QTF adenylosuccinate lyase FR848_18530 ENOG4105XJC Two component transcriptional regulator (Winged helix family FR848_18535 ENOG4105IFJ Histidine kinase FR848_18540 ENOG4105EZE Cupin 4 family protein FR848_18555 ENOG4105F38 ABC transporter, permease FR848_18560 ENOG4105D38 putrescine abc transporter FR848_18565 ENOG4107RUE extracellular solute-binding protein family 1 FR848_18575 ENOG4105CV1 Transketolase (EC 2.2.1.1) FR848_18580 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FR848_18585 ENOG4108YZG isomerase FR848_18595 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) FR848_18600 ENOG4105G63 Type III effector Hrp-dependent FR848_18615 ENOG4105DKT Transcriptional regulator FR848_18620 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FR848_18625 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) FR848_18630 ENOG4105D60 lipoprotein releasing system transmembrane protein FR848_18640 ENOG4105D60 lipoprotein releasing system transmembrane protein FR848_18645 ENOG4108JA2 transcriptioN-repair coupling factor FR848_18650 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FR848_18655 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction FR848_18660 ENOG4108IND Tetr family transcriptional regulator FR848_18670 ENOG4107MBR 17 kDa surface antigen FR848_18675 ENOG4105CEP NADH dehydrogenase FR848_18680 ENOG4105D0Y UPF0227 protein FR848_18695 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) FR848_18700 ENOG41090DQ Lipoprotein FR848_18705 ENOG4105K59 histidine triad (HIT) protein FR848_18715 ENOG4105CNM Receptor FR848_18720 ENOG4105CI1 PTS System FR848_18725 ENOG4105F8V Hydrolase, tatD family FR848_18730 ENOG4107QRG dna polymerase iii FR848_18735 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FR848_18740 ENOG4105HHA aminodeoxychorismate lyase FR848_18745 ENOG4105YAZ 4-amino-4-deoxychorismate lyase FR848_18750 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FR848_18755 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FR848_18760 ENOG4105CHR reductase FR848_18765 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FR848_18770 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FR848_18785 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FR848_18790 ENOG4108UHJ MAF-like protein FR848_18800 ENOG4105EI2 Pseudouridine synthase FR848_18805 ENOG4107QQB Ribonuclease E FR848_18810 ENOG4105EJC lysr family transcriptional regulator FR848_18815 ENOG4105EQ0 Major Facilitator superfamily FR848_18820 ENOG4105CJR Integral membrane protein (MviN FR848_18825 ENOG4105EP9 oxidoreductase FR848_18835 ENOG4105D9U N-acetyltransferase FR848_18845 ENOG4105E9S glutaredoxin 2 FR848_18850 ENOG4105F3T (LipO)protein FR848_18855 ENOG4105EKE dihydroorotase FR848_18860 ENOG4105MEA DNA damage-inducible protein i FR848_18865 ENOG4105PVA Biofilm formation regulatory protein BssS FR848_18870 ENOG4105F76 Sarcosine oxidase FR848_18875 ENOG4106974 biofilm formation FR848_18885 ENOG4105D1S lipid A biosynthesis FR848_18895 ENOG4108W47 Acidic protein msyB FR848_18900 ENOG4105NAC (LipO)protein FR848_18935 ENOG4108UQ5 membrane protein YcdZ FR848_18940 ENOG4107XHZ cytoplasmic chaperone TorD family protein FR848_18960 ENOG4105HEI LysR family (Transcriptional regulator FR848_18965 ENOG4105EUB pirin domain protein FR848_18970 ENOG4105CHJ isochorismatase hydrolase FR848_18990 ENOG41062D9 Histidine kinase FR848_19010 ENOG4105D5M phosphate starvation-inducible protein FR848_19015 ENOG4105DBE peroxidase FR848_19020 ENOG410650H (LipO)protein FR848_19025 ENOG4105EKT )-iron permease FR848_19030 ENOG4105D9N nucleoside FR848_19040 ENOG4105CK7 Sodium proline symporter FR848_19045 ENOG4105C26 Dehydrogenase FR848_19055 ENOG4108R86 Transcriptional regulator FR848_19065 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FR848_19080 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FR848_19090 ENOG4105C2W permease FR848_19100 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 FR848_19110 ENOG4105XH3 FR848_19115 ENOG4105D6F Phosphatase FR848_19130 ENOG4105CUB amino acid FR848_19140 ENOG4105CFQ glutamine synthetase FR848_19145 ENOG4108Z86 Glutamine amidotransferase FR848_19150 ENOG4107VRI Transcriptional regulator FR848_19155 ENOG4105C26 Dehydrogenase FR848_19160 ENOG4105CJP fad dependent oxidoreductase FR848_19165 ENOG4105EJC lysr family transcriptional regulator FR848_19170 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FR848_19175 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FR848_19180 ENOG4105DM4 PTS System FR848_19185 ENOG4108YRF PTS System FR848_19190 ENOG4105C6N Formate acetyltransferase FR848_19195 ENOG4108AHH pyruvate formate lyase II activase FR848_19200 ENOG4108XCZ PTS System FR848_19210 ENOG4106R3P AraC family transcriptional regulator FR848_19215 ENOG4105BZU Histidine kinase FR848_19235 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FR848_19245 ENOG4108PU9 oligogalacturonate-specific porin FR848_19250 ENOG41061NF Pectate lyase FR848_19260 ENOG4105C5R Aminotransferase FR848_19270 ENOG4105E5Q amino acid AbC transporter FR848_19290 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FR848_19325 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FR848_19330 ENOG4107QUY Guanine deaminase FR848_19335 ENOG41084YZ Hydrolase FR848_19345 ENOG4105C2W permease FR848_19350 ENOG41061H0 Monooxygenase FR848_19395 ENOG41064T2 transcriptional regulator, lysR family FR848_19415 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FR848_19425 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase FR848_19435 ENOG4108M8W Monooxygenase FR848_19440 ENOG4105KME endoribonuclease L-psp FR848_19450 ENOG4105GR3 Histidine kinase FR848_19455 ENOG4105E3W Two component transcriptional regulator (Winged helix family FR848_19465 ENOG4105BZS acriflavin resistance protein FR848_19475 ENOG4105VEQ Cold shock protein FR848_19480 ENOG4105VEQ Cold shock protein FR848_19485 ENOG4107QPK )-transporter FR848_19490 ENOG4107QIJ Aconitate hydratase 2 FR848_19500 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase FR848_19510 ENOG4105CHY citrate lyase, alpha FR848_19515 ENOG4105CI0 Citrate lyase FR848_19520 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) FR848_19525 ENOG4105DUA (citrate (pro-3S)-lyase ligase FR848_19530 ENOG4105ERH Fumarylacetoacetate hydrolase FR848_19535 ENOG4105D94 Major Facilitator Superfamily FR848_19540 ENOG4105C7F AcnD-accessory protein PrpF FR848_19545 ENOG4105F04 LysR family Transcriptional regulator FR848_19565 ENOG4105E5Q amino acid AbC transporter FR848_19570 ENOG4105CDA abc transporter atp-binding protein FR848_19575 ENOG4105CM2 brancheD-chain amino acid aminotransferase FR848_19600 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FR848_19625 ENOG4105CIS alcohol dehydrogenase FR848_19630 ENOG4108W6C Dehydrogenase FR848_19640 ENOG4105E7U AraC family transcriptional regulator FR848_19650 ENOG4105SUT Transcriptional Regulator AraC Family FR848_19660 ENOG4105C0R drug resistance transporter emrb qaca subfamily FR848_19675 ENOG4107R0W ABC transporter FR848_19680 ENOG4105E5Q amino acid AbC transporter FR848_19685 ENOG4105CDA abc transporter atp-binding protein FR848_19690 ENOG4107PP3 Acetylornithine deacetylase FR848_19700 ENOG4105ENR peptidase, M24 FR848_19705 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FR848_19710 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FR848_19715 ENOG4105CHM Aminotransferase FR848_19720 ENOG4105FDP GntR family transcriptional regulator FR848_19730 ENOG4105ETZ PTS System FR848_19735 ENOG4105F3R pts system mannose fructose sorbose family iid FR848_19740 ENOG4108IQ3 PTS system FR848_19745 ENOG4108SU4 UPF0309 protein FR848_19750 ENOG4105EP8 Glycosyl Hydrolase Family 88 FR848_19755 ENOG4108SU4 UPF0309 protein FR848_19760 ENOG4105EPF Outer membrane porin FR848_19775 ENOG4107QSI ABC, transporter FR848_19780 ENOG4108MN8 Membrane FR848_19790 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FR848_19795 ENOG4108UQN AraC family transcriptional regulator FR848_19800 ENOG4108V1U phospholipid-binding protein FR848_19825 ENOG4107TYR Glycosyl Transferase FR848_19835 ENOG4108JJA ABC, transporter FR848_19850 ENOG4105K4P CoA-binding domain protein FR848_19860 ENOG41088T4 Helicase IV FR848_19865 ENOG410901E Membrane FR848_19870 ENOG4105EM2 membrane FR848_19875 ENOG4108RZ1 DNA transformation protein FR848_19880 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) FR848_19885 ENOG4105UYK outer membrane protein a FR848_19890 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) FR848_19895 ENOG4105DAN ATP-dependent protease FR848_19905 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) FR848_19910 ENOG4108Q2G (LipO)protein FR848_19915 ENOG4105DY2 Paraquat-inducible protein b FR848_19920 ENOG4105F1S paraquat-inducible protein a FR848_19925 ENOG4105C5H ABC transporter FR848_19930 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FR848_19935 ENOG4105QVC MOSC domain-containing protein FR848_19940 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) FR848_19950 ENOG4108UZX fmn reductase FR848_19955 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FR848_19960 ENOG4105E2Y ABC, transporter FR848_19965 ENOG4105CD8 aminopeptidase N FR848_19975 ENOG4105C5S asparaginyl-tRNA synthetase FR848_19980 ENOG4105ZIT Porin Gram-negative type FR848_19985 ENOG4105CGF Aromatic amino acid aminotransferase FR848_19990 ENOG4105C5X domain protein FR848_19995 ENOG4105EAQ (twin-arginine translocation) pathway signal FR848_20000 ENOG4105DIT ErfK YbiS YcfS YnhG family protein FR848_20005 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) FR848_20010 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) FR848_20015 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) FR848_20020 ENOG4106371 Methyltransferase FR848_20025 ENOG4107S90 membrAne FR848_20030 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups FR848_20035 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FR848_20040 ENOG4105W49 UPF0434 protein FR848_20045 ENOG4105T0Z Conserved Protein FR848_20050 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FR848_20055 ENOG4105BZ1 (ABC) transporter FR848_20060 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 FR848_20070 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FR848_20075 ENOG4105CAT Cytidine monophosphate kinase FR848_20085 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FR848_20090 ENOG4107VMU Membrane FR848_20095 ENOG4105DDY UPF0142 protein ycaO FR848_20100 ENOG4105TMB Formate nitrite transporter FR848_20105 ENOG4105C6N Formate acetyltransferase FR848_20110 ENOG4105F1A Pyruvate formate-lyase FR848_20130 ENOG4108HHA Transketolase FR848_20135 ENOG4108IUS Transketolase FR848_20140 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FR848_20145 ENOG4108ISG Major Facilitator FR848_20150 ENOG4107KGK dmso reductase anchor subunit FR848_20155 ENOG4105QAX Iron-sulfur FR848_20160 ENOG4107QY8 reductase FR848_20165 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FR848_20170 ENOG4105D1H recombination factor protein RarA FR848_20180 ENOG4105CNU cell division protein FtsK FR848_20185 ENOG4105EW9 transcriptional regulator AsnC family FR848_20190 ENOG4105C3M thioredoxin reductase FR848_20195 ENOG4108JJ9 ABC, transporter FR848_20200 ENOG4108JJ8 (ABC) transporter FR848_20205 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FR848_20215 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FR848_20220 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FR848_20230 ENOG4105VEQ Cold shock protein FR848_20240 ENOG4105DJY efflux transporter, rnd family, mfp subunit FR848_20245 ENOG4105CPB ATP-dependent endonuclease of the OLD family FR848_20250 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FR848_20255 ENOG4105DWU Membrane FR848_20260 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FR848_20265 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FR848_20275 ENOG4105C7K acetolactate synthase FR848_20280 ENOG4105C5W Aldolase FR848_20285 ENOG4105CGD Nad-dependent epimerase dehydratase FR848_20290 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FR848_20295 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FR848_20300 ENOG4105K8R UPF0145 protein FR848_20305 ENOG41064MM (LipO)protein FR848_20310 ENOG4105E5Z arginine transporter ATP-binding subunit FR848_20315 ENOG4106PMH Extracellular solute-binding protein family 3 FR848_20320 ENOG4105GBT ABC transporter FR848_20325 ENOG4105DMR ABC, transporter FR848_20330 ENOG4106TNF Periplasmic binding protein FR848_20335 ENOG4105ES5 Histidine kinase FR848_20340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FR848_20350 ENOG4105RBQ inner membrane protein ybjO FR848_20355 ENOG4105D38 putrescine abc transporter FR848_20360 ENOG4105F38 ABC transporter, permease FR848_20365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FR848_20370 ENOG4107RUE extracellular solute-binding protein family 1 FR848_20375 ENOG4108RMJ sensory transduction regulator FR848_20385 ENOG4108DBC nitroreductase FR848_20390 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress FR848_20395 ENOG41090BQ Glutaredoxin FR848_20400 ENOG4105GWF inner membrane protein YbjM FR848_20480 ENOG4108RFG Tetr family transcriptional regulator FR848_20485 ENOG4106UW1 Major Facilitator superfamily FR848_20490 ENOG4108HCJ Hydrolase FR848_20495 ENOG4107QF7 multi-drug FR848_20500 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FR848_20505 ENOG4107FB0 transcriptional regulator DeoR family FR848_20510 ENOG4105DZ1 carboxypeptidase FR848_20515 ENOG4108TGY Glutathione S-transferase FR848_20520 ENOG4105D8V Glucose sorbosone dehydrogenase FR848_20525 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway FR848_20530 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FR848_20545 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FR848_20550 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FR848_20555 ENOG4105DEF Extracellular solute-binding protein, family 5 FR848_20560 ENOG4108JQ6 ABC transporter FR848_20565 ENOG4105D44 asparaginase FR848_20575 ENOG4105CVM Molybdenum cofactor synthesis domain protein FR848_20580 ENOG4105D06 uba thif-type nad fad binding protein FR848_20585 ENOG4105F1A Pyruvate formate-lyase FR848_20590 ENOG4105C6N Formate acetyltransferase FR848_20595 ENOG4108HCJ Hydrolase FR848_20600 ENOG41072TH Protein of unknown function (DUF1479) FR848_20605 ENOG4105ETE Transcriptional regulator (LacI family FR848_20610 ENOG4105DPW Major facilitator superfamily MFS_1 FR848_20625 ENOG4105C5H ABC transporter FR848_20635 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FR848_20640 ENOG4108TZY GntR Family Transcriptional Regulator FR848_20645 ENOG4105CS2 ec 3.2.1.21 FR848_20650 ENOG4105CPC Aldo Keto reductase FR848_20655 ENOG4105F4P )-transporter FR848_20660 ENOG4105KST dependent repressor FR848_20670 ENOG4108I6E Sulfatase FR848_20675 ENOG4108T1M outer membrane protein x FR848_20685 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction FR848_20690 ENOG4107R0W ABC transporter FR848_20695 ENOG4105E5Q amino acid AbC transporter FR848_20700 ENOG4105CDA abc transporter atp-binding protein FR848_20710 ENOG4105D8X mechanosensitive ion channel FR848_20715 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) FR848_20725 ENOG4108IU3 tonb-dependent siderophore receptor FR848_20735 ENOG4105KSC Transcriptional regulator, TraR DksA family FR848_20740 ENOG4105VR4 UPF0379 protein ybiJ FR848_20745 ENOG4108MTB glycosyl transferase family FR848_20750 ENOG4105DVT helicase FR848_20755 ENOG4105C1J atp-dependent rna helicase FR848_20775 ENOG4105DJB Major Facilitator Superfamily FR848_20785 ENOG4108PZW LysR family Transcriptional regulator FR848_20790 ENOG4107MVR Transcriptional regulator FR848_20795 ENOG4105D0S secretion protein (HlyD FR848_20800 ENOG4105CJ1 ABC, transporter FR848_20805 ENOG4107QWP ABC-2 type transporter FR848_20810 ENOG4107QWP ABC-2 type transporter FR848_20815 ENOG4105I9U inner membrane protein ybhQ FR848_20820 ENOG4105X23 Endonuclease Exonuclease phosphatase FR848_20825 ENOG4105DZQ phospholipase D Transphosphatidylase FR848_20830 ENOG4107UXM Membrane FR848_20835 ENOG4105HFZ Membrane FR848_20840 ENOG4108ZAF Molybdopterin FR848_20845 ENOG4105M00 molybdopterin converting factor, subunit 1 FR848_20850 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FR848_20855 ENOG4108RIR Molybdenum cofactor biosynthesis protein FR848_20860 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FR848_20865 ENOG4105CHW UPF0052 protein FR848_20870 ENOG4105DIJ Phosphoethanolamine transferase FR848_20875 ENOG4105XJC Two component transcriptional regulator (Winged helix family FR848_20880 ENOG4105ECM Sensor protein basS pmrB FR848_20900 ENOG4108IV0 ABC, transporter FR848_20910 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FR848_20925 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FR848_20930 ENOG4108V1U phospholipid-binding protein FR848_20935 ENOG4105C85 amino acid FR848_20945 ENOG4105CGP Urocanate hydratase FR848_20960 ENOG4105NBR Pectinesterase FR848_20975 ENOG4108XDN Transcriptional regulator FR848_20980 ENOG4105BZU Histidine kinase FR848_20985 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component FR848_21005 ENOG4105K5X acetyltransferase FR848_21010 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FR848_21015 ENOG4108K4B hydrolase FR848_21020 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FR848_21025 ENOG4105E0C molybdate abc transporter FR848_21030 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FR848_21035 ENOG410680R Protein of unknown function (DUF2592) FR848_21040 ENOG4105F4R Transcriptional regulator mode FR848_21045 ENOG4105DKW ABC transporter FR848_21050 ENOG4105CMR udp-glucose 4-epimerase FR848_21055 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FR848_21060 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FR848_21065 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FR848_21075 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FR848_21080 ENOG4105JND homeobox protein FR848_21085 ENOG4105PGM cation diffusion facilitator family transporter FR848_21090 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FR848_21095 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FR848_21130 ENOG4105UFD tol-pal system protein YbgF FR848_21135 ENOG4105KCK Peptidoglycan-associated lipoprotein FR848_21145 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA FR848_21150 ENOG4105M8F Biopolymer transport protein exbD tolR FR848_21155 ENOG4105E02 MotA TolQ exbB proton channel FR848_21160 ENOG4107YD3 Thioesterase FR848_21165 ENOG4105KJB cyd operon protein YbgE FR848_21175 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FR848_21180 ENOG4105C4M (Ubiquinol oxidase) subunit I FR848_21185 ENOG4107WFU Glutamate mutase subunit sigma FR848_21195 ENOG4105DJI Methylaspartate mutase, E subunit FR848_21215 ENOG4105CK2 sodium dicarboxylate symporter FR848_21220 ENOG4105CSV Glutaminase FR848_21225 ENOG4107GFK fumarate FR848_21230 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FR848_21240 ENOG4105ETT transcriptional Regulator, LysR family FR848_21245 ENOG4107XVH Transcriptional regulator FR848_21250 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FR848_21260 ENOG4105C7S Dehydrogenase FR848_21265 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FR848_21270 ENOG4105E33 succinate dehydrogenase FR848_21275 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FR848_21280 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FR848_21285 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FR848_21290 ENOG4105BZN citrate synthase FR848_21295 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) FR848_21315 ENOG4105E7W lamb ycsf family protein FR848_21320 ENOG4107R7A Allophanate hydrolase subunit 2 FR848_21325 ENOG4105P4J Allophanate hydrolase, subunit 1 FR848_21330 ENOG4107QNR UPF0135 protein FR848_21340 ENOG4105CVP deoxyribo-dipyrimidine photolyase FR848_21345 ENOG4105XIQ Protein of unknown function (DUF2517) FR848_21365 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FR848_21370 ENOG4105C08 Histidine kinase FR848_21375 ENOG4105EEX Two component transcriptional regulator (Winged helix family FR848_21385 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase FR848_21390 ENOG4105CMG Carbohydrate kinase FR848_21395 ENOG4105CNN ABC, transporter FR848_21400 ENOG4105C2J ABC transporter FR848_21405 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FR848_21410 ENOG4105CPQ Dehydrogenase FR848_21415 ENOG4105E98 transcriptional regulator DeoR family FR848_21425 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 FR848_21430 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) FR848_21435 ENOG4105EV9 Alpha Beta Hydrolase FR848_21440 ENOG4105NNH LexA regulated protein FR848_21445 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) FR848_21450 ENOG41090R7 Ferric uptake FR848_21455 ENOG4106P55 Transcriptional regulator FR848_21460 ENOG4107EFR Flavocytochrome c FR848_21475 ENOG4105GX6 (LipO)protein FR848_21490 ENOG4105CX6 glutaminyL-tRNA synthetase FR848_21495 ENOG4105CI1 PTS System FR848_21505 ENOG4105CE4 GlcNAc 6-P deacetylase FR848_21510 ENOG4105E2R ROK family FR848_21515 ENOG4105D4U had-superfamily hydrolase, subfamily iia FR848_21520 ENOG4105CAQ asparagine synthetase FR848_21560 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FR848_21565 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FR848_21570 ENOG4105C9A Phoh family FR848_21575 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FR848_21580 ENOG4108JU5 Magnesium and cobalt efflux protein FR848_21585 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FR848_21590 ENOG4107RP9 extracellular solute-binding protein, family 3 FR848_21595 ENOG4105EAD ABC transporter FR848_21600 ENOG4105DRP amino acid AbC transporter FR848_21605 ENOG4105CDA abc transporter atp-binding protein FR848_21610 ENOG4105D5K Hemolysin activator protein FR848_21620 ENOG4107PAI alpha helical protein FR848_21625 ENOG4105C8T Leucyl-tRNA synthetase FR848_21635 ENOG4105DJF DNA polymerase III, delta' subunit FR848_21640 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FR848_21645 ENOG4108TGR phosphatase FR848_21650 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FR848_21660 ENOG4105CJN penicillin-binding protein FR848_21665 ENOG4105CNI cell division protein FtsW FR848_21670 ENOG4105K6T rare lipoprotein A FR848_21675 ENOG4105DZ1 carboxypeptidase FR848_21680 ENOG4108Z43 UPF0250 protein FR848_21690 ENOG41064T2 transcriptional regulator, lysR family FR848_21695 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FR848_21700 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FR848_21705 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FR848_21715 ENOG4105VEQ Cold shock protein FR848_21720 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) FR848_21725 ENOG4105CEE C4-dicarboxylate transporter FR848_21730 ENOG4105KTS ribonuclease FR848_21735 ENOG4105NXH GreA GreB family elongation factor FR848_21740 ENOG4108U51 Universal stress protein FR848_21745 ENOG4108JU3 Alkyl hydroperoxide reductase FR848_21755 ENOG4105D3R alkyl hydroperoxide reductase FR848_21760 ENOG4105DQS Transcriptional regulator FR848_21765 ENOG4105BZV Phosphoadenosine phosphosulfate reductase FR848_21770 ENOG4105GTN ParB Domain Protein Nuclease FR848_21775 ENOG4105CHM Aminotransferase FR848_21780 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) FR848_21785 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FR848_21805 ENOG4105C2J ABC transporter FR848_21825 ENOG4108M3J Dehydrogenase FR848_21840 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin FR848_21850 ENOG4105DZC cytosine deaminase FR848_21855 ENOG4105ETE Transcriptional regulator (LacI family FR848_21860 ENOG4105ECY inositol monophosphatase FR848_21865 ENOG4105CXY transporter FR848_21870 ENOG4105D6F Phosphatase FR848_21880 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FR848_21895 ENOG4105CNN ABC, transporter FR848_21900 ENOG4105C2J ABC transporter FR848_21905 ENOG4107SCQ Iron-containing alcohol dehydrogenase FR848_21920 ENOG4105VCD cytoplasmic protein FR848_21925 ENOG4105D22 carbon starvation protein FR848_21935 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) FR848_21940 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FR848_21945 ENOG4105WQI isochorismatase FR848_21950 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FR848_21955 ENOG4105E4F Isochorismate synthase FR848_21960 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein FR848_21975 ENOG4105E8G Major facilitator Superfamily FR848_21980 ENOG4105DQ5 transport system permease protein FR848_21985 ENOG4105TVJ transport system, permease FR848_21990 ENOG4105E0A ABC, transporter FR848_21995 ENOG4105C0W non-ribosomal peptide synthetase FR848_22000 ENOG41085A6 mbth domain-containing protein FR848_22005 ENOG4105E93 esterase FR848_22010 ENOG4107RNH Outer membrane receptor FepA FR848_22015 ENOG4108TSE Transferase FR848_22020 ENOG4108IUS Transketolase FR848_22025 ENOG4108HHA Transketolase FR848_22030 ENOG4105DKT Transcriptional regulator FR848_22035 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FR848_22040 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FR848_22050 ENOG4105C2J ABC transporter FR848_22055 ENOG4105CNN ABC, transporter FR848_22065 ENOG4108R85 Short chain dehydrogenase FR848_22070 ENOG4107635 Hok Gef family protein FR848_22075 ENOG4105C94 Transporter FR848_22105 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FR848_22110 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FR848_22115 ENOG4105C3U ABC transporter FR848_22120 ENOG4108JQ7 (ABC) transporter FR848_22125 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FR848_22130 ENOG4105EMU Dehydrogenase FR848_22140 ENOG4105E5Q amino acid AbC transporter FR848_22145 ENOG4105E5Q amino acid AbC transporter FR848_22160 ENOG410829K Lysine exporter protein (Lyse ygga) FR848_22175 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FR848_22180 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FR848_22185 ENOG4105C3U ABC transporter FR848_22195 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FR848_22210 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) FR848_22215 ENOG4108T58 Mg2 transport protein CorA FR848_22225 ENOG4105ENT Efflux transporter rnd family, mfp subunit FR848_22235 ENOG4105WQ6 Membrane FR848_22245 ENOG4105E0K tonB-dependent siderophore receptor FR848_22250 ENOG4105HFT AraC family transcriptional regulator FR848_22265 ENOG4105MSB protein, conserved in bacteria FR848_22270 ENOG4108RCM Nitroreductase FR848_22310 ENOG4105PBE general secretion pathway protein h FR848_22320 ENOG4105D7Q type ii secretion system FR848_22325 ENOG4107QHF type ii secretion system protein e FR848_22340 ENOG4108HKT sucrose-6-phosphate hydrolase FR848_22345 ENOG4105F3R pts system mannose fructose sorbose family iid FR848_22350 ENOG4105ETZ PTS System FR848_22355 ENOG4108IQ3 PTS system FR848_22360 ENOG4108EQA pts system FR848_22370 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FR848_22385 ENOG4105CUY Mechanosensitive ion channel FR848_22395 ENOG4105M6F mutator MutT protein FR848_22405 ENOG4108GWT fimbrillin MatB FR848_22415 ENOG4108N3D putative enzyme FR848_22420 ENOG4106PYX Receptor FR848_22430 ENOG4105ISV protein with bipartite regulator domain FR848_22435 ENOG4105CBN LysR family transcriptional regulator FR848_22440 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FR848_22460 ENOG4105EAA nucleoside FR848_22465 ENOG4105C85 amino acid FR848_22475 ENOG4105CPC Aldo Keto reductase FR848_22480 ENOG4105E89 ABC transporter FR848_22485 ENOG4105CH2 amidohydrolase FR848_22510 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) FR848_22515 ENOG4105E0A ABC, transporter FR848_22540 ENOG4105WBN Transcriptional regulator (LacI family FR848_22555 ENOG4105CID antiterminator FR848_22560 ENOG4105CS2 ec 3.2.1.21 FR848_22565 ENOG4105C5Y PTS System FR848_22570 ENOG4105CNN ABC, transporter FR848_22575 ENOG4105C2J ABC transporter FR848_22600 ENOG4108J4B Beta-lactamase FR848_22610 ENOG4105CRK lysyL-tRNA synthetase FR848_22620 ENOG4105DUX Transporter FR848_22625 ENOG4105CXN decarboxylase FR848_22630 ENOG4105D5Q Arginine ornithine antiporter FR848_22640 ENOG4108M3R transcriptional activator CadC FR848_22650 ENOG4105ETT transcriptional Regulator, LysR family FR848_22660 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FR848_22690 ENOG4105WQ3 Rna-binding protein FR848_22700 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FR848_22710 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FR848_22715 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FR848_22730 ENOG4105N0V mono-oxygenase ydhR FR848_22735 ENOG4105CV6 ABC transporter, permease FR848_22740 ENOG4108I0Y (ABC) transporter FR848_22745 ENOG4108UJV acyl-CoA thioesterase i FR848_22750 ENOG4105E1F short-chain dehydrogenase reductase FR848_22755 ENOG4107QR8 Thioredoxin FR848_22760 ENOG4105C4B ABC transporter, permease FR848_22765 ENOG41083J0 (ABC) transporter FR848_22770 ENOG4107QX8 SPFH domain, Band 7 family protein FR848_22775 ENOG4105G5H Membrane FR848_22790 ENOG4108Z6Z Transcriptional regulator FR848_22795 ENOG4105C59 p-type ATPase FR848_22825 ENOG4105MBR gumn family FR848_22830 ENOG4108Z66 YbaK ebsC protein FR848_22835 ENOG4105CGH 5'-nucleotidase FR848_22840 ENOG4105EU0 Major facilitator Superfamily FR848_22845 ENOG4105CKD glutathione-regulated potassium-efflux system protein FR848_22850 ENOG4107RE1 Inosine-guanosine kinase FR848_22865 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FR848_22880 ENOG4107QMP dna polymerase iii subunits gamma and tau FR848_22890 ENOG4105WD1 Membrane FR848_22895 ENOG4108URS primosomal replication protein n'' FR848_22900 ENOG4106428 Protein of unknown function (DUF2496) FR848_22910 ENOG4105EGS Mechanosensitive ion channel FR848_22915 ENOG4108IG5 Transcriptional regulator FR848_22920 ENOG4105C1P efflux transporter, rnd family, mfp subunit FR848_22925 ENOG4105BZS acriflavin resistance protein FR848_22930 ENOG4108UKR Biofilm formation regulator YbaJ FR848_22940 ENOG4108UW5 maltose o-acetyltransferase FR848_22945 ENOG4105GSJ Inner membrane protein ylaC FR848_22960 ENOG4105YK5 50S ribosomal protein L36 FR848_22965 ENOG4105NRA 50s ribosomal protein l31 type b FR848_22970 ENOG4105ETE Transcriptional regulator (LacI family FR848_22975 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FR848_22980 ENOG4105CI1 PTS System FR848_22985 ENOG4105C4C beta-galactosidase FR848_22995 ENOG4105EG2 ABC transporter, permease FR848_23005 ENOG4107FKK extracellular solute-binding protein family 1 FR848_23015 ENOG41066DG (EAL) domain protein FR848_23025 ENOG41061MD high-affinity nickel-transporter FR848_23030 ENOG4105KCV RNA signal recognition particle 4.5S RNA FR848_23035 ENOG4108VW9 Membrane FR848_23065 ENOG41080UX Methyltransferase FR848_23070 ENOG4108MNP Glycoprotein polysaccharide metabolism FR848_23075 ENOG4105C29 acyl-CoA thioesterase FR848_23080 ENOG4105BZU Histidine kinase FR848_23085 ENOG4108YZA Nitrogen regulatory protein pii FR848_23095 ENOG4105BZ1 (ABC) transporter FR848_23100 ENOG4105BZ1 (ABC) transporter FR848_23105 ENOG4108XM1 transcriptional regulator AsnC family FR848_23120 ENOG4108NFA extracellular solute-binding protein FR848_23130 ENOG4108TGP Thioesterase superfamily protein FR848_23135 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FR848_23145 ENOG4105EIN peptidylprolyl cis-trans isomerase FR848_23150 ENOG4105K70 DNA-binding protein FR848_23155 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FR848_23185 ENOG4105M85 Bola protein FR848_23190 ENOG4105IEY (LipO)protein FR848_23195 ENOG4105EYM Major Facilitator superfamily FR848_23200 ENOG4105E2S oxidase) subunit II FR848_23205 ENOG4105BZ9 Cytochrome C oxidase, subunit I FR848_23210 ENOG4105CCU oxidase (Subunit III) FR848_23215 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FR848_23220 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FR848_23230 ENOG4107HP6 Transcriptional regulator FR848_23235 ENOG4105E2X shikimate dehydrogenase FR848_23240 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein FR848_23260 ENOG4105D2S major facilitator superfamily FR848_23270 ENOG4105CT4 transporter FR848_23275 ENOG4105CIB oxidoreductase Domain protein FR848_23280 ENOG4107RDB Major Facilitator FR848_23285 ENOG4108VPT UPF0234 protein FR848_23290 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FR848_23295 ENOG4107S0N DJ-1 family FR848_23300 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FR848_23310 ENOG4105CTB Polyprenyl synthetase FR848_23320 ENOG4105CPC Aldo Keto reductase FR848_23325 ENOG4108ZAI phosphatidylglycerophosphatase a FR848_23330 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FR848_23335 ENOG4107YIM Involved in the transcription termination process (By similarity) FR848_23340 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FR848_23345 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FR848_23355 ENOG4108KIC (LipO)protein FR848_23360 ENOG4105DRB nucleoside-specific channel-forming protein FR848_23380 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FR848_23385 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FR848_23390 ENOG4105VIE preprotein translocase, subunit YajC FR848_23395 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FR848_23405 ENOG4108ZYK Acyl carrier protein phosphodiesterase FR848_23410 ENOG4105D3R alkyl hydroperoxide reductase FR848_23425 ENOG4105EFZ amidohydrolase FR848_23435 ENOG4105CHJ isochorismatase hydrolase FR848_23440 ENOG4105EQ1 Transcriptional regulator FR848_23445 ENOG4107R28 alpha amylase, catalytic region FR848_23450 ENOG4105C85 amino acid FR848_23455 ENOG4105CWM branched-chain amino acid transport system II carrier protein FR848_23460 ENOG4105BZU Histidine kinase FR848_23465 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FR848_23470 ENOG4107RH8 nuclease SbcCD subunit D FR848_23475 ENOG4105EYH Exonuclease FR848_23485 ENOG4105DKQ ROK family FR848_23500 ENOG4105HBA AroM protein FR848_23505 ENOG4105SS3 FR848_23510 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FR848_23515 ENOG4105G4C Periplasmic ligand-binding sensor protein FR848_23525 ENOG4105II7 pyrroline-5-carboxylate reductase FR848_23530 ENOG4105VIF phosphate starvation-inducible protein FR848_23535 ENOG4105G6Z alkaline phosphatase FR848_23545 ENOG4105K2J Transcriptional regulator FR848_23555 ENOG4105CHR reductase FR848_23570 ENOG4105CPF Cell wall formation (By similarity) FR848_23575 ENOG4105UNH Membrane FR848_23580 ENOG4105FR5 inner membrane protein YaiY FR848_23585 ENOG4107QS8 (LipO)protein FR848_23590 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 FR848_23600 ENOG4107R6D beta-lactam binding protein AmpH FR848_23605 ENOG4105D52 delta-aminolevulinic acid dehydratase FR848_23610 ENOG4108UK5 Transposase FR848_23620 ENOG4105E2B Taurine dioxygenase FR848_23625 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FR848_23635 ENOG4106FTQ Taurine ABC transporter, periplasmic FR848_23640 ENOG4108KX4 response regulator FR848_23645 ENOG4105BZU Histidine kinase FR848_23650 ENOG4105CXY transporter FR848_23655 ENOG4105C4Y ABC transporter FR848_23660 ENOG4107RCV ABC transporter, permease FR848_23665 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FR848_23670 ENOG4107QK5 Homocysteine s-methyltransferase FR848_23675 ENOG4108IQI permease FR848_23685 ENOG4105C85 amino acid FR848_23690 ENOG4105CPD ethanolamine ammonia-lyase FR848_23695 ENOG4107FQ9 ethanolamine ammonia-lyase FR848_23710 ENOG4105C32 Amino acid ABC transporter (Permease) FR848_23715 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FR848_23720 ENOG4105C0Z ABC transporter FR848_23725 ENOG4108IV0 ABC, transporter FR848_23735 ENOG4105CT1 (ABC) transporter FR848_23740 ENOG4105CDA abc transporter atp-binding protein FR848_23745 ENOG4105E5Q amino acid AbC transporter FR848_23750 ENOG4105DRP amino acid AbC transporter FR848_23760 ENOG4106PYX Receptor FR848_23765 ENOG4108N3D putative enzyme FR848_23770 ENOG4108NN8 Fimbrial protein FR848_23790 ENOG4105EHI Phosphonate ABC transporter, periplasmic FR848_23800 ENOG4105S7S phosphonate abc transporter FR848_23820 ENOG4105K63 Thioredoxin FR848_23835 ENOG4105GVF (ABC) transporter FR848_23840 ENOG41090KR LysR family transcriptional Regulator FR848_23845 ENOG4108QBX (LipO)protein FR848_23850 ENOG4105FCK Membrane FR848_23855 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FR848_23860 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FR848_23945 ENOG4105DXI Major Facilitator superfamily FR848_23960 ENOG4105ETS cytosine purines uracil thiamine allantoin FR848_23970 ENOG4108IJ8 ABC transporter FR848_23975 ENOG4105E90 ABC transporter FR848_23980 ENOG4105E90 ABC transporter FR848_23990 ENOG4105C84 Histidine ammonia-lyase FR848_23995 ENOG41090B9 response to stress FR848_24000 ENOG4105CZE histidine utilization repressor FR848_24005 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FR848_24010 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FR848_24020 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FR848_24030 ENOG41079KZ Major Facilitator Superfamily FR848_24035 ENOG4105TW1 Carbohydrate-selective porin OprB FR848_24040 ENOG4105DTA methyltransferase FR848_24045 ENOG41080VW acetyltransferase FR848_24060 ENOG4105DEI Mannitol dehydrogenase FR848_24065 ENOG4105C6F GntR Family Transcriptional Regulator FR848_24085 ENOG4105C26 Dehydrogenase FR848_24090 ENOG4105D3Q Sugar transferase FR848_24120 ENOG4106WTF Glycosyl transferase, family 2 FR848_24125 ENOG4105CG5 Glycosyl transferase (Group 1 FR848_24130 ENOG4107RA4 Glycosyl transferase (Group 1 FR848_24145 ENOG4105D7W serine acetyltransferase FR848_24150 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) FR848_24165 ENOG4105CIN aminoacyl-histidine dipeptidase FR848_24170 ENOG4108HYG acetyltransferase FR848_24175 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FR848_24190 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) FR848_24195 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FR848_24200 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FR848_24205 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FR848_24220 ENOG4105F7V ErfK ybiS ycfS ynhG family protein FR848_24225 ENOG4105E7A Glutamine amidotransferase FR848_24235 ENOG4107QPN acyl-Coa dehydrogenase FR848_24240 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FR848_24250 ENOG4108JDX DNA polymerase iii, epsilon subunit FR848_24255 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FR848_24260 ENOG4105D1A Methyltransferase FR848_24265 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FR848_24270 ENOG4105E9H Lytic Murein transglycosylase FR848_24275 ENOG4105F2W methyltransferase FR848_24285 ENOG4105F27 Major Facilitator FR848_24290 ENOG4105HEI LysR family (Transcriptional regulator FR848_24295 ENOG4105CV8 reductase FR848_24330 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FR848_24335 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FR848_24340 ENOG4108UMI ABC transporter, permease FR848_24345 ENOG4105D01 (LipO)protein FR848_24350 ENOG4108R8X outer membrane lipoprotein FR848_24355 ENOG4108R96 Methyltransferase, YaeB family FR848_24360 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FR848_24365 ENOG4108UY0 (LipO)protein FR848_24370 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion FR848_24375 ENOG4108YZN class I peptide chain release factor FR848_24380 ENOG4108VWS Yaeq family FR848_24385 ENOG4105W1I UPF0253 protein FR848_24390 ENOG4105M1T rho-binding antiterminator FR848_24395 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FR848_24400 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FR848_24405 ENOG4105CXN decarboxylase FR848_24415 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FR848_24420 ENOG4105C0B DNA polymerase III (alpha subunit) FR848_24425 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FR848_24445 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FR848_24450 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FR848_24455 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FR848_24460 ENOG4105DZP Membrane-associated zinc metalloprotease FR848_24465 ENOG4105KNE Phosphatidate cytidylyltransferase FR848_24480 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FR848_24495 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FR848_24505 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FR848_24510 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FR848_24520 ENOG4108T8E UPF0325 protein FR848_24530 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FR848_24535 ENOG4105C0H protease FR848_24540 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FR848_24545 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FR848_24550 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FR848_24555 ENOG4105EN6 Membrane FR848_24565 ENOG4105CMQ Chloride channel FR848_24570 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FR848_24575 ENOG4108A32 Transposase FR848_24580 ENOG4105S6R Iron-hydroxamate transporter permease subunit FR848_24585 ENOG4105J76 Periplasmic binding protein FR848_24590 ENOG4105E0A ABC, transporter FR848_24595 ENOG4105E0K tonB-dependent siderophore receptor FR848_24600 ENOG4105BZ4 penicillin-binding protein FR848_24685 ENOG4105CQ7 ATP-dependent helicase FR848_24690 ENOG4107XID 2'-5' rna ligase FR848_24695 ENOG4105PW4 Sugar fermentation stimulation protein homolog FR848_24700 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FR848_24710 ENOG4105DJ0 Poly(A) Polymerase FR848_24715 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FR848_24720 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FR848_24735 ENOG4105X0I Fimbrial FR848_24740 ENOG4108VEV chaperone FR848_24745 ENOG4105CW0 outer membrane usher protein FR848_24770 ENOG4107BJW polysaccharide deacetylase FR848_24775 ENOG4108YTN IIa component FR848_24780 ENOG4105E3A (ABC) transporter FR848_24785 ENOG4105DA5 (ABC) transporter FR848_24790 ENOG41077A9 carbonic anhydrase FR848_24795 ENOG4108UGV hypoxanthine phosphoribosyltransferase FR848_24800 ENOG4105DZG Dehydrogenase FR848_24805 ENOG4105E3B Multicopper oxidase FR848_24810 ENOG4108ZRK uncharacterized protein yacC FR848_24820 ENOG4108V1T peptidylprolyl cis-trans isomerase FR848_24825 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FR848_24835 ENOG4105MVE transcriptional regulator FR848_24840 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FR848_24845 ENOG4107S2N Type III effector Hrp-dependent FR848_24850 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) FR848_24860 ENOG4107QIJ Aconitate hydratase 2 FR848_24865 ENOG4108NST exported protein FR848_24880 ENOG4107QN2 dihydrolipoyl dehydrogenase FR848_24885 ENOG4107QSN dihydrolipoamide acetyltransferase FR848_24890 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FR848_24895 ENOG41073TP transcriptional regulator FR848_24905 ENOG4105C85 amino acid FR848_24910 ENOG4105CT4 transporter FR848_24915 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) FR848_24920 ENOG4106A72 regulatory protein AmpE FR848_24930 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FR848_24935 ENOG4108ZUW Major pilin subunit FR848_24940 ENOG4107QHF type ii secretion system protein e FR848_24945 ENOG4105D7Q type ii secretion system FR848_24955 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FR848_24965 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) FR848_24970 ENOG4105M6F mutator MutT protein FR848_24975 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FR848_24980 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) FR848_24985 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FR848_24990 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FR848_24995 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FR848_25000 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FR848_25005 ENOG4105CPF Cell wall formation (By similarity) FR848_25015 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FR848_25020 ENOG4105CNI cell division protein FtsW FR848_25030 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FR848_25035 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FR848_25040 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FR848_25045 ENOG4105CJN penicillin-binding protein FR848_25050 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FR848_25065 ENOG4107B7Y DNA-binding transcriptional regulator FruR FR848_25070 ENOG4108ZP8 Acetolactate synthase small subunit FR848_25075 ENOG4105C7K acetolactate synthase FR848_25080 ENOG41064T2 transcriptional regulator, lysR family FR848_25090 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FR848_25095 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FR848_25105 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FR848_25115 ENOG4105E2X shikimate dehydrogenase FR848_25120 ENOG4105EMV Major Facilitator FR848_25125 ENOG4105FF2 Type I DHQase FR848_25130 ENOG4108W5M transcriptional regulator FR848_25135 ENOG4105DJB Major Facilitator Superfamily FR848_25140 ENOG4105S8Q sugar efflux transporter FR848_25160 ENOG4105DP9 ABC transporter FR848_25165 ENOG4106SMU thiamine transporter membrane protein FR848_25175 ENOG4108KF1 Membrane FR848_25180 ENOG41063TF transcriptional regulator (AraC FR848_25190 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FR848_25195 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FR848_25200 ENOG4105CQ2 DNA polymerase FR848_25210 ENOG4105D3G Pseudouridine synthase FR848_25220 ENOG4105D2K citrate carrier protein FR848_25225 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FR848_25230 ENOG4106YYS transcriptional regulatory protein FR848_25235 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) FR848_25250 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FR848_25255 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FR848_25270 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FR848_25285 ENOG4105M5B (LipO)protein FR848_25290 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FR848_25295 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FR848_25300 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FR848_25305 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase FR848_25310 ENOG4105CHY citrate lyase, alpha FR848_25315 ENOG4105CI0 Citrate lyase FR848_25325 ENOG4105DUA (citrate (pro-3S)-lyase ligase FR848_25340 ENOG4107QSA Oxaloacetate decarboxylase FR848_25345 ENOG4105D9Q decarboxylase (Beta subunit) FR848_25350 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FR848_25355 ENOG4106YYS transcriptional regulatory protein FR848_25360 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FR848_25365 ENOG4105EXG Transcriptional regulator FR848_25370 ENOG4107QM5 aconitate hydratase FR848_25375 ENOG4105C8P )-transporter FR848_25380 ENOG4107QPK )-transporter FR848_25385 ENOG4105C7F AcnD-accessory protein PrpF FR848_25390 ENOG4105F04 LysR family Transcriptional regulator FR848_25395 ENOG4105DU0 nucleoside hydrolase FR848_25400 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FR848_25405 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FR848_25420 ENOG4105DTN riboflavin biosynthesis protein ribF FR848_25440 ENOG41063Z6 transcriptional regulator, lysR family FR848_25445 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FR848_25450 ENOG4108PNB DNA-binding transcriptional regulator FR848_25485 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FR848_25490 ENOG4105CFG Acts as a chaperone (By similarity) FR848_25500 ENOG4108QUJ UPF0174 protein YaaW FR848_25505 ENOG4106HK8 GPR1 FUN34 yaaH family protein FR848_25510 ENOG4105CSH Transporter FR848_25515 ENOG4108RIR Molybdenum cofactor biosynthesis protein FR848_25525 ENOG4105BZG amino acid carrier protein FR848_25530 ENOG4105D1Q UPF0246 protein FR848_25535 ENOG4105D98 threonine synthase FR848_25540 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FR848_25545 ENOG4105CFH Aspartokinase FR848_25555 ENOG4106FVC RNA methyltransferase FR848_25560 ENOG410759A FR848_25565 ENOG41065U4 response regulator FR848_25570 ENOG4105CT7 inner membrane cred family protein FR848_25575 ENOG4105EB3 Histidine kinase FR848_25580 ENOG4105E3W Two component transcriptional regulator (Winged helix family FR848_25585 ENOG4108RH0 Crea protein FR848_25590 ENOG4105UEI Transcriptional Regulator AraC Family FR848_25595 ENOG4105CVJ phosphoglycerate mutase FR848_25605 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) FR848_25610 ENOG4107SC1 transglycosylase FR848_25615 ENOG4105C5H ABC transporter FR848_25620 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase FR848_25625 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FR848_25630 ENOG4105EAC phosphoserine phosphatase FR848_25635 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) FR848_25645 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FR848_25665 ENOG4105D9N nucleoside FR848_25670 ENOG4105EYA deoxyribonuclease FR848_25675 ENOG4108NRW Phospholipase, patatin family FR848_25685 ENOG4105K3G Periplasmic Protein FR848_25690 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FR848_25695 ENOG4105PAD Hydrolase FR848_25700 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FR848_25705 ENOG4108WPU DNA polymerase III subunit psi FR848_25730 ENOG4105YBH Protein of unknown function (DUF1435) FR848_25735 ENOG4106TD9 Diguanylate cyclase FR848_25740 ENOG4108819 ferric iron reductase FR848_25745 ENOG4105CK1 PTS System FR848_25750 ENOG4108UIN ybak prolyl-trna synthetase associated region FR848_25755 ENOG4108T94 DNA-binding transcriptional activator BglJ FR848_25760 ENOG4108N8T regulatoR FR848_25765 ENOG4108R6W Transcriptional regulator, ARAC family FR848_25770 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase FR848_25775 ENOG4105DWK Membrane FR848_25785 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) FR848_25790 ENOG4106CVF DNA replication protein FR848_25795 ENOG4105RI1 glycoprotein receptor FR848_25805 ENOG4105DNE Transposase FR848_25810 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FR848_25815 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FR848_25820 ENOG4105F3R pts system mannose fructose sorbose family iid FR848_25825 ENOG4105ETZ PTS System FR848_25840 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FR848_25845 ENOG4107QZW Altronate oxidoreductase FR848_25850 ENOG4105CPQ Dehydrogenase FR848_25855 ENOG410617M Transcriptional regulator FR848_25860 ENOG4108I5G Major Facilitator superfamily FR848_25865 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FR848_25870 ENOG4105XYF acetyltransferase FR848_25875 ENOG4106KNT transcriptional regulator FR848_25880 ENOG4108RTU Aldolase FR848_25885 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 FR848_25890 ENOG4108IA2 Sodium pantothenate symporter FR848_25905 ENOG4105DFA alanine racemase domain protein FR848_25910 ENOG4108V8F Transcriptional regulator, MarR family FR848_25915 ENOG4105ERH Fumarylacetoacetate hydrolase FR848_25925 ENOG4105C26 Dehydrogenase FR848_25930 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase FR848_25960 ENOG4105EFA 4-hydroxyphenylacetate FR848_25970 ENOG4105D22 carbon starvation protein FR848_25975 ENOG4105VCD cytoplasmic protein FR848_25980 ENOG4105CKI cobalamin synthesis protein FR848_25995 ENOG4105C26 Dehydrogenase FR848_26005 ENOG41063TF transcriptional regulator (AraC FR848_26010 ENOG4105E82 cytochrome subunit of dehydrogenase FR848_26020 ENOG4106BRA Membrane FR848_26025 ENOG41083G8 Multidrug resistance protein MdtM FR848_26030 ENOG4105GTN ParB Domain Protein Nuclease FR848_26035 ENOG4105BZV Phosphoadenosine phosphosulfate reductase FR848_26045 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase FR848_26050 ENOG4105CIZ coA-substrate-specific enzyme activase FR848_26065 ENOG4108P2H Inner membrane protein YjiG FR848_26070 ENOG41074DU domain protein FR848_26075 ENOG4105DND Transcriptional regulator FR848_26085 ENOG4105EFX secretion protein, HlyD family FR848_26095 ENOG4106DIZ Domain of unknown function (DUF1127) FR848_26100 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FR848_26110 ENOG4108F3G Type I restriction-modification system, R subunit FR848_26135 ENOG4105CUB amino acid FR848_26160 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FR848_26180 ENOG4105KNY Microcompartments protein FR848_26185 ENOG4105KNY Microcompartments protein FR848_26190 ENOG4105KNY Microcompartments protein FR848_26195 ENOG4108EKI Dehydrogenase FR848_26210 ENOG4105C6N Formate acetyltransferase FR848_26215 ENOG4105F1A Pyruvate formate-lyase FR848_26220 ENOG4105KNY Microcompartments protein FR848_26225 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) FR848_26255 ENOG4105CIC tryptophan-specific transport protein FR848_26265 ENOG4105BZU Histidine kinase FR848_26270 ENOG4105D0S secretion protein (HlyD FR848_26275 ENOG4105CJ1 ABC, transporter FR848_26280 ENOG4105CMI transporter FR848_26310 ENOG4105EZE Cupin 4 family protein FR848_26315 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FR848_26330 ENOG4105CSH Transporter FR848_26340 ENOG4105C54 Major Facilitator superfamily FR848_26345 ENOG4105CXK mandelate racemase muconate lactonizing FR848_26350 ENOG4108R85 Short chain dehydrogenase FR848_26365 ENOG4105WBN Transcriptional regulator (LacI family FR848_26395 ENOG4106H3A restriction FR848_26430 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles FR848_26435 ENOG4105ZS6 Protein of unknown function (DUF987) FR848_26440 ENOG4108XS9 dna repair protein FR848_26445 ENOG4105MFG Antirestriction protein FR848_26450 ENOG4106H6R UPF0380 protein FR848_26475 ENOG4108QDQ Ubiquinol-cytochrome C chaperone FR848_26480 ENOG4108P8R FR848_26520 ENOG4105DZR Type I site-specific deoxyribonuclease FR848_26550 ENOG4105DQ4 alcohol dehydrogenase FR848_26560 ENOG4105DRS transport system, permease FR848_26565 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FR848_26570 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FR848_26580 ENOG4107QNK )-transporter FR848_26585 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FR848_26590 ENOG4105F0H myo-inositol catabolism protein FR848_26600 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FR848_26605 ENOG4105D7K pfkb domain protein FR848_26610 ENOG4105CHC glucokinase (EC 2.7.1.2) FR848_26615 ENOG4105DH8 myo-inositol catabolism FR848_26620 ENOG4105C26 Dehydrogenase FR848_26630 ENOG4105D7A ATP-binding protein FR848_26635 ENOG4108K5H permease YjgP YjgQ family protein FR848_26640 ENOG4108M8S permease YjgP YjgQ family protein FR848_26650 ENOG4105MYG DNA polymerase iii, chi subunit FR848_26655 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FR848_26660 ENOG4108MJ3 acetyltransferase FR848_26670 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase FR848_26675 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) FR848_26680 ENOG4105DBV ornithine carbamoyltransferase FR848_26685 ENOG4105XEP YhcH YjgK YiaL family protein FR848_26695 ENOG41077AM PyrBI operon attenuator FR848_26705 ENOG4105CXT aspartate transcarbamylase FR848_26710 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) FR848_26715 ENOG4108M1A Chitin-binding protein FR848_26720 ENOG4105KME endoribonuclease L-psp FR848_26735 ENOG4105D4X repressor FR848_26740 ENOG4105C5Y PTS System FR848_26745 ENOG4105CG3 alpha amylase, catalytic region FR848_26750 ENOG4105CK1 PTS System FR848_26755 ENOG4105F8D glycoside hydrolase family 4 FR848_26770 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FR848_26775 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FR848_26780 ENOG4105CS6 Rhs element vgr protein FR848_26805 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FR848_26820 ENOG41069H0 dihydroorotase EC 3.5.2.3 FR848_26850 ENOG4108XVM Cytochrome b(562) FR848_26855 ENOG4105CMS peptidase U62, modulator of DNA gyrase FR848_26860 ENOG4105N42 UPF0307 protein FR848_26865 ENOG4105C26 Dehydrogenase FR848_26885 ENOG4105DFU Cell wall formation (By similarity) FR848_26895 ENOG41062B0 ABC transporter, permease FR848_26900 ENOG4107R9N ABC transporter FR848_26905 ENOG4105C2J ABC transporter FR848_26910 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator FR848_26915 ENOG4105F0N pyrophosphate phospho-hydrolase FR848_26920 ENOG4108ZHD aig2 family FR848_26925 ENOG4105MA0 exported protein FR848_26930 ENOG4105CFU surface antigen FR848_26940 ENOG4105C37 (CBS) domain FR848_26950 ENOG4105C4C beta-galactosidase FR848_26960 ENOG41061GZ Protein of unknown function (DUF1107) FR848_26965 ENOG4108UUE Transcriptional regulator FR848_26970 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FR848_26975 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FR848_26980 ENOG4105KVH Transcriptional regulator FR848_26985 ENOG4105ECR NmrA family FR848_26995 ENOG4105DXC membrane FR848_27000 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FR848_27010 ENOG4108V1T peptidylprolyl cis-trans isomerase FR848_27020 ENOG4105FHY Opacity-associated protein A FR848_27030 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FR848_27035 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FR848_27040 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) FR848_27050 ENOG4105KIT UPF0379 protein yjfY FR848_27080 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport FR848_27100 ENOG4108MXZ Esterase FR848_27105 ENOG4105WSB biofilm stress and motility protein A FR848_27110 ENOG4105S17 UPF0379 protein yjfN FR848_27115 ENOG4105CSU acyl-Coa dehydrogenase FR848_27125 ENOG4105C2N RNA methyltransferase TrmH family group 3 FR848_27130 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FR848_27150 ENOG4105EPW hflc protein FR848_27155 ENOG4107QJR hflk protein FR848_27160 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FR848_27165 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FR848_27180 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FR848_27185 ENOG4105K8N protein family UPF0079, ATPase FR848_27190 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FR848_27195 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FR848_27215 ENOG4106TNF Periplasmic binding protein FR848_27220 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FR848_27230 ENOG4105DJ4 phosphatidylserine decarboxylase FR848_27235 ENOG4105EGS Mechanosensitive ion channel FR848_27240 ENOG4107SC7 Inner membrane transporter yjeM FR848_27250 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FR848_27255 ENOG4105E33 succinate dehydrogenase FR848_27270 ENOG4105QNF Outer membrane lipoprotein FR848_27275 ENOG4105KPY Small multidrug resistance protein FR848_27295 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FR848_27310 ENOG4108NAE Fimbrial chaperone protein FR848_27315 ENOG4105CW0 outer membrane usher protein FR848_27330 ENOG4108MBX Secretion Protein FR848_27335 ENOG4108JJA ABC, transporter FR848_27345 ENOG4108ZVF (LipO)protein FR848_27350 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FR848_27360 ENOG4105DVH amino acid FR848_27365 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 FR848_27370 ENOG4108IJ0 Aspartate ammonia-lyase FR848_27375 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FR848_27385 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FR848_27390 ENOG4108SIC Transcriptional regulator FR848_27405 ENOG4107S6X Glycosyl transferase, family 2 FR848_27420 ENOG4105DYS nad(p)h dehydrogenase (quinone) FR848_27435 ENOG4108ZCF integral membrane protein FR848_27455 ENOG4105CSH Transporter FR848_27460 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FR848_27465 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase FR848_27470 ENOG4107RJJ Transcriptional regulator FR848_27475 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG FR848_27480 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH FR848_27485 ENOG4105EKV Phosphonate metabolism protein FR848_27490 ENOG4105FT8 Phosphonate metabolism FR848_27495 ENOG4105ENV phosphonate C-P lyase system protein PhnK FR848_27500 ENOG4105HRV phosphonate c-p lyase system protein phnl FR848_27505 ENOG4105FD8 phosphonate metabolism protein PhnM FR848_27510 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) FR848_27515 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein FR848_27525 ENOG4108YZG isomerase FR848_27530 ENOG4105NYY transcriptional regulator, RpiR FR848_27535 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FR848_27540 ENOG4105C2J ABC transporter FR848_27545 ENOG4105CNN ABC, transporter FR848_27550 ENOG4105UP7 3-epimerase FR848_27555 ENOG4107TFG D-allose kinase FR848_27565 ENOG41082ND Uncharacterized protein yjcO FR848_27570 ENOG4105CK2 sodium dicarboxylate symporter FR848_27580 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FR848_27585 ENOG41062QD Membrane FR848_27605 ENOG4105CW0 outer membrane usher protein FR848_27610 ENOG4108VCD Chaperone FR848_27620 ENOG41067MG lrgb family FR848_27630 ENOG4105CMU LysR family (Transcriptional regulator FR848_27635 ENOG4105EEQ Na H antiporter FR848_27640 ENOG4105C7N Xanthine uracil vitamin C permease FR848_27645 ENOG4108K3A Glutathione S-transferase FR848_27650 ENOG4108Z4X TRANSCRIPTIONal FR848_27655 ENOG4108W3Q Transcriptional regulator FR848_27660 ENOG4108M8H domain protein FR848_27665 ENOG4105PMV Membrane FR848_27675 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FR848_27680 ENOG4108DMH HTH_ARAC FR848_27685 ENOG4107RNH Outer membrane receptor FepA FR848_27690 ENOG4105E4C Lytic transglycosylase catalytic FR848_27695 ENOG4108UUM single-stranded DNA-binding protein FR848_27700 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FR848_27715 ENOG4105MSB protein, conserved in bacteria FR848_27720 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FR848_27730 ENOG4105CGF Aromatic amino acid aminotransferase FR848_27735 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FR848_27740 ENOG4105CDU Replicative dna helicase FR848_27745 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FR848_27750 ENOG4105P4Z Phage shock protein G FR848_27755 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FR848_27765 ENOG4105MYN Zinc uptake regulation protein FR848_27770 ENOG4105VDW Csbd family FR848_27775 ENOG4107R73 Mate efflux family protein FR848_27780 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FR848_27785 ENOG41080IJ Diacylglycerol kinase FR848_27790 ENOG4105E55 glycerol-3-phosphate acyltransferase FR848_27800 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) FR848_27805 ENOG4107W52 maltose operon periplasmic protein FR848_27810 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FR848_27820 ENOG4107FKK extracellular solute-binding protein family 1 FR848_27825 ENOG4105D56 permease protein FR848_27830 ENOG4105EG2 ABC transporter, permease FR848_27835 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FR848_27840 ENOG4105CEM UPF0597 protein FR848_27855 ENOG4105KME endoribonuclease L-psp FR848_27865 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FR848_27875 ENOG4105CFH Aspartokinase FR848_27880 ENOG410756H nucleotidyltransferase FR848_27895 ENOG4105CYB regulatoR FR848_27900 ENOG4105C09 Bile acid FR848_27905 ENOG4108ZR5 Conserved Protein FR848_27910 ENOG4105FE9 pseudouridine synthase FR848_27915 ENOG4105DKT Transcriptional regulator FR848_27920 ENOG4105CHR reductase FR848_27925 ENOG4108XCU pts system FR848_27930 ENOG4105KPI PTS system sorbose subfamily IIB component FR848_27935 ENOG4105ETZ PTS System FR848_27940 ENOG4105F3R pts system mannose fructose sorbose family iid FR848_27945 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein FR848_27950 ENOG4105F9E Shikimate 5-dehydrogenase FR848_27970 ENOG4106JVB Replication Protein FR848_28055 ENOG410624V efflux system protein FR848_28085 ENOG4105DR5 peptidase FR848_28095 ENOG4105E3B Multicopper oxidase FR848_28100 ENOG4105VR0 copper resistance FR848_28105 ENOG4105JDN Copper resistance protein FR848_28110 ENOG4108PG2 copper resistance FR848_28115 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FR848_28120 ENOG4105GR3 Histidine kinase FR848_28160 ENOG4105KF5 hemolysin expression-modulating protein FR848_28190 ENOG4105CXG d-lactate dehydrogenase FR848_28195 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FR848_28200 ENOG4107QR9 Iron-sulfur cluster binding protein FR848_28205 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FR848_28210 ENOG4107EFN gluconate transport system permease 3 FR848_28215 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) FR848_28325 ENOG4105F2I Transposase FR848_28365 ENOG4105D13 transposase FR848_28375 ENOG4105KPY Small multidrug resistance protein FR848_28385 ENOG41082CG Protein CrcB homolog FR848_28400 ENOG4105CHH sulfate transporter FR848_28410 ENOG4108C33 Resolvase FR848_28480 ENOG4105ETE Transcriptional regulator (LacI family FR848_28490 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FR848_28525 ENOG4106CQM replication FR848_28570 ENOG4105ETS cytosine purines uracil thiamine allantoin FR848_28595 ENOG41090B9 response to stress FR848_28600 ENOG4105CZE histidine utilization repressor FR848_28605 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FR848_28615 ENOG4105ETS cytosine purines uracil thiamine allantoin FR848_28620 ENOG4105CEY Amp-dependent synthetase and ligase FR848_28650 ENOG4108JEH abc transporter atp-binding protein FR848_28655 ENOG4105E5Q amino acid AbC transporter FR848_28660 ENOG4105E5Q amino acid AbC transporter FR848_28670 ENOG4105ETT transcriptional Regulator, LysR family FR848_28685 ENOG4107CBI conjugal transfer fertility inhibition protein FR848_28945 ENOG4108UUM single-stranded DNA-binding protein FR848_28985 ENOG4105MPK DNA polymerase III subunit theta FR848_29005 ENOG41073YN Protein of unknown function (DUF1380) FR848_29070 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB FR848_29075 ENOG4105EZN Cobyrinic acid ac-diamide synthase FR848_29080 ENOG4106CQM replication FR848_29110 ENOG4108UTZ Dihydroxyacetone kinase FR848_29115 ENOG4105E5H Transposase FR848_29120 ENOG4108YXQ IS66 Orf2 family protein FR848_29130 ENOG4105CMT Dihydroxyacetone kinase FR848_29170 ENOG4105YCI dehydratase medium subunit FR848_29175 ENOG4108ZFT Dehydratase small subunit FR848_29225 ENOG41085W3 Transposase FR848_29230 ENOG4108YDI single-species biofilm formation on inanimate substrate FR848_29235 ENOG41061MD high-affinity nickel-transporter FR848_29245 ENOG4107Y80 Major Facilitator superfamily FR848_29305 ENOG41074AV Hok/gef family FR848_29390 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A FR848_29435 ENOG41060ND LF82 chromosome, complete sequence FR848_29485 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit FR848_29490 ENOG4105CM2 brancheD-chain amino acid aminotransferase FR848_29500 ENOG4105C7B Threonine dehydratase FR848_29510 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) FR848_29515 ENOG4105DT3 PTS system, galactitol-specific IIc component FR848_29530 ENOG4105CMT Dihydroxyacetone kinase FR848_29545 ENOG4105RKW reductase (By FR848_29550 ENOG4108UTZ Dihydroxyacetone kinase FR848_29555 ENOG4105CMT Dihydroxyacetone kinase FR848_29560 ENOG4105EMY transcriptional regulator FR848_29570 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FR848_29595 ENOG4105DEF Extracellular solute-binding protein, family 5 FR848_29600 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FR848_29610 ENOG4108JQ7 (ABC) transporter FR848_29615 ENOG4105FDP GntR family transcriptional regulator FR848_29620 ENOG4105DER m42 family FR848_29625 ENOG4105MTM Protein of unknown function (DUF1496) FR848_29630 ENOG4108IYH Dna topoisomerase FR848_29705 ENOG4105EKQ RNA-directed DNA polymerase FR848_29830 ENOG4105MPK DNA polymerase III subunit theta FR848_29850 ENOG4108UUM single-stranded DNA-binding protein FR848_30090 ENOG4107CBI conjugal transfer fertility inhibition protein FR848_30150 ENOG4108UUM single-stranded DNA-binding protein FR848_30165 ENOG4105CNW domain protein FR848_30285 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FR848_30440 ENOG4105VUN Transcriptional regulator