locus-tag class description HJW72_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HJW72_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HJW72_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HJW72_00025 ENOG410667J hydrolase HJW72_00040 ENOG4105EMF GntR family transcriptional regulator HJW72_00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HJW72_00050 ENOG4108RTU Aldolase HJW72_00055 ENOG4105CXK mandelate racemase muconate lactonizing HJW72_00060 ENOG4105DJB Major Facilitator Superfamily HJW72_00065 ENOG4105D99 atp gtp-binding protein HJW72_00070 ENOG4105R2A (LipO)protein HJW72_00085 ENOG4105F5P DNA-damage-inducible protein d HJW72_00090 ENOG4105D0C transport protein HJW72_00095 ENOG4105FDP GntR family transcriptional regulator HJW72_00100 ENOG4105CI1 PTS System HJW72_00105 ENOG4105F8D glycoside hydrolase family 4 HJW72_00110 ENOG4105VG5 Membrane HJW72_00115 ENOG4105JP4 Inner membrane protein yidG HJW72_00140 ENOG4105W8I Transcriptional regulator HJW72_00145 ENOG4105E5M Multidrug resistance protein D HJW72_00175 ENOG4105C7K acetolactate synthase HJW72_00180 ENOG4105M71 acetolactate synthase 1 regulatory subunit HJW72_00185 ENOG4108KX4 response regulator HJW72_00190 ENOG4105BZU Histidine kinase HJW72_00195 ENOG4105CXY transporter HJW72_00200 ENOG4105CXY transporter HJW72_00205 ENOG4108SAJ Protein of unknown function (DUF1198) HJW72_00225 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HJW72_00230 ENOG4107STF Involved in phosphonate degradation (By similarity) HJW72_00235 ENOG4106S9K Transcriptional regulator HJW72_00250 ENOG4108MP3 ABC transporter, permease HJW72_00260 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJW72_00265 ENOG4105VCP PTS System HJW72_00270 ENOG4105CK1 PTS System HJW72_00280 ENOG4105ETE Transcriptional regulator (LacI family HJW72_00285 ENOG4105D2S major facilitator superfamily HJW72_00295 ENOG4107F9Y LysR family transcriptional regulator HJW72_00305 ENOG4105JSC dimethylmenaquinone methyltransferase HJW72_00320 ENOG4105T8A Uncharacterized protein YicS HJW72_00325 ENOG4108UZ3 Transporter HJW72_00330 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) HJW72_00335 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HJW72_00340 ENOG4105C2C drug resistance transporter, Bcr CflA HJW72_00345 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HJW72_00350 ENOG4105BZS acriflavin resistance protein HJW72_00355 ENOG4105C1P efflux transporter, rnd family, mfp subunit HJW72_00375 ENOG410630P Transcriptional regulator HJW72_00385 ENOG4105CR8 Transcriptional regulator HJW72_00410 ENOG4105D01 (LipO)protein HJW72_00425 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HJW72_00435 ENOG4105DQ4 alcohol dehydrogenase HJW72_00455 ENOG4105NI3 Protein of unknown function (DUF3237) HJW72_00465 ENOG4105CT4 transporter HJW72_00470 ENOG4105CJQ hydrolase, family 31 HJW72_00480 ENOG4105F8D glycoside hydrolase family 4 HJW72_00485 ENOG4105CI1 PTS System HJW72_00490 ENOG4105JV1 AsmA family HJW72_00495 ENOG4105C2W permease HJW72_00500 ENOG4105D6U Sodium Glutamate Symporter HJW72_00505 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HJW72_00510 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HJW72_00515 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HJW72_00520 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HJW72_00535 ENOG4105CP7 Triose-phosphate isomerase HJW72_00540 ENOG4105EBK exported protein HJW72_00545 ENOG4108VTS Membrane HJW72_00550 ENOG4105DP0 ferredoxin-NADP reductase HJW72_00555 ENOG4105CBT Fructose-1,6-bisphosphatase HJW72_00560 ENOG4105CB5 ATP-dependent DNA helicase recG HJW72_00565 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HJW72_00570 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HJW72_00580 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HJW72_00585 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HJW72_00590 ENOG4105EN6 Membrane HJW72_00600 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HJW72_00605 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) HJW72_00615 ENOG4105DSJ YicC domain protein HJW72_00640 ENOG4105CJ1 ABC, transporter HJW72_00645 ENOG4107QWP ABC-2 type transporter HJW72_00650 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HJW72_00665 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HJW72_00670 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HJW72_00675 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HJW72_00680 ENOG4105W5Q DNA repair protein (RadC HJW72_00685 ENOG4105KDC 50s ribosomal protein l28 HJW72_00690 ENOG4105W0E 50S ribosomal protein L33 HJW72_00695 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HJW72_00700 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HJW72_00705 ENOG4106WTF Glycosyl transferase, family 2 HJW72_00710 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HJW72_00715 ENOG4105K64 Glycosyl transferase, family 2 HJW72_00720 ENOG4105CPK Glycosyl transferase (Group 1 HJW72_00730 ENOG4105DKP glycosyl transferase, family 9 HJW72_00755 ENOG4105D16 lipopolysaccharide heptosyltransferase i HJW72_00760 ENOG4105XA0 heptosyltransferase ii HJW72_00765 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HJW72_00770 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HJW72_00775 ENOG4105CPQ Dehydrogenase HJW72_00780 ENOG4106WTF Glycosyl transferase, family 2 HJW72_00785 ENOG4105PXI polysaccharide deacetylase HJW72_00790 ENOG41063SB peptidase HJW72_00800 ENOG4107YZP Rhodanese domain protein HJW72_00805 ENOG4105VW4 glutaredoxin 3 HJW72_00810 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HJW72_00815 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HJW72_00820 ENOG4105D7W serine acetyltransferase HJW72_00825 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HJW72_00830 ENOG4105DMF Dehydrogenase HJW72_00835 ENOG41073TP transcriptional regulator HJW72_00840 ENOG4105DAA L-lactate HJW72_00845 ENOG4108YYI Protein of unknown function (DUF2810) HJW72_00855 ENOG4105E61 Mannitol repressor protein HJW72_00865 ENOG4105CTS PTS system mannitol-specific HJW72_00875 ENOG4108U78 Glutathione S-transferase HJW72_00880 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HJW72_00885 ENOG4105EM7 Selenocysteine-specific translation elongation factor HJW72_00890 ENOG4105J4Q Transcriptional regulator HJW72_00895 ENOG4108RC0 Electron transport protein HJW72_00900 ENOG4105JKW Valine--pyruvate aminotransferase HJW72_00905 ENOG4107T9C Alpha amylase catalytic region HJW72_00910 ENOG4108UR8 BAX protein HJW72_00915 ENOG4105T16 Transcriptional regulator (AraC family) HJW72_00920 ENOG4108HWW ABC transporter HJW72_00930 ENOG4105DFW ABC transporter HJW72_00935 ENOG4105C93 Xylose Isomerase HJW72_00940 ENOG4105CMG Carbohydrate kinase HJW72_00945 ENOG410688U Inner membrane protein yiaB HJW72_00950 ENOG4108Z12 YiaAB two helix domain-containing protein HJW72_00955 ENOG4105MEV Acyl-transferase HJW72_00965 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HJW72_00970 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HJW72_00975 ENOG41060TC Hok gef cell toxic protein HJW72_00990 ENOG4105MVF Transcriptional regulator HJW72_00995 ENOG4105D2S major facilitator superfamily HJW72_01000 ENOG4106JH6 (LipO)protein HJW72_01005 ENOG4105C5I Dehydrogenase HJW72_01015 ENOG4105D7K pfkb domain protein HJW72_01025 ENOG4108M60 Transcriptional regulator HJW72_01035 ENOG4108ZG0 Ompa motb domain protein HJW72_01040 ENOG4107QY8 reductase HJW72_01045 ENOG4105HNP -acetyltransferase HJW72_01050 ENOG4108R3E Dna-3-methyladenine glycosylase i HJW72_01055 ENOG4105EAX Putative lipase HJW72_01060 ENOG4105FCD Major Facilitator HJW72_01065 ENOG4105DIJ Phosphoethanolamine transferase HJW72_01085 ENOG4105DEF Extracellular solute-binding protein, family 5 HJW72_01090 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJW72_01095 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJW72_01100 ENOG4105C3U ABC transporter HJW72_01105 ENOG4108JQ7 (ABC) transporter HJW72_01120 ENOG4107U53 septum site-determining protein minD HJW72_01125 ENOG4107QZ7 Cellulose synthase catalytic subunit HJW72_01130 ENOG4107EEX Cellulose synthase regulator protein HJW72_01135 ENOG4105EJG cellulose synthase HJW72_01150 ENOG4105D1V cellulose synthase operon protein YhjU HJW72_01155 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT HJW72_01160 ENOG4105U74 cellulose biosynthesis protein BcsE HJW72_01165 ENOG410661M cytoplasmic protein HJW72_01170 ENOG4105UTS cellulose synthase operon protein YhjQ HJW72_01175 ENOG4107QZ7 Cellulose synthase catalytic subunit HJW72_01180 ENOG4107EEX Cellulose synthase regulator protein HJW72_01185 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HJW72_01190 ENOG4105EJG cellulose synthase HJW72_01195 ENOG4105BZU Histidine kinase HJW72_01200 ENOG4105CK2 sodium dicarboxylate symporter HJW72_01205 ENOG4105CS0 peptidase HJW72_01220 ENOG41066T0 asmA family HJW72_01225 ENOG4105CSH Transporter HJW72_01230 ENOG4107H3J ribonuclease HJW72_01235 ENOG4105CBN LysR family transcriptional regulator HJW72_01240 ENOG4105CHR reductase HJW72_01255 ENOG4105C0A alcohol dehydrogenase HJW72_01265 ENOG4105DC8 reductase HJW72_01270 ENOG4105D6S protein involved in catabolism of external DNA HJW72_01275 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HJW72_01280 ENOG4105DGW oligopeptidase A HJW72_01285 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HJW72_01290 ENOG4105DUX Transporter HJW72_01300 ENOG4108V6B universal stress protein B HJW72_01305 ENOG4105CJ3 phosphate transporter HJW72_01310 ENOG4105CBX hi0933 family HJW72_01315 ENOG4105CJW magnesium transporter HJW72_01325 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HJW72_01335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJW72_01340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJW72_01345 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HJW72_01355 ENOG4105PY6 Phenolic acid decarboxylase HJW72_01360 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HJW72_01365 ENOG4105CKK Glycosyl transferase, family 2 HJW72_01370 ENOG4105C3I Nad-dependent epimerase dehydratase HJW72_01375 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HJW72_01380 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HJW72_01385 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HJW72_01390 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HJW72_01395 ENOG4105DSF transport protein HJW72_01400 ENOG4105F9N Major Facilitator Superfamily HJW72_01405 ENOG4108W1V Lipoprotein HJW72_01410 ENOG4105EX9 Membrane HJW72_01415 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HJW72_01425 ENOG4107FS9 Membrane HJW72_01435 ENOG4105MG3 Membrane HJW72_01440 ENOG4106H78 methyltransferase HJW72_01445 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HJW72_01450 ENOG4105CAK Cell division ATP-binding protein ftsE HJW72_01455 ENOG4105CRP Part of the ABC transporter FtsEX involved in HJW72_01470 ENOG4108JPW Aminotransferase HJW72_01480 ENOG4105CP9 extracellular ligand-binding receptor HJW72_01485 ENOG4105U59 -acetyltransferase HJW72_01490 ENOG4105CP9 extracellular ligand-binding receptor HJW72_01495 ENOG4105C32 Amino acid ABC transporter (Permease) HJW72_01500 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HJW72_01505 ENOG4105C0Z ABC transporter HJW72_01510 ENOG4108IV0 ABC, transporter HJW72_01515 ENOG41060M8 Pfam:PhdYeFM HJW72_01525 ENOG4105BZ7 extracellular solute-binding protein family 1 HJW72_01530 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HJW72_01545 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HJW72_01550 ENOG4105WC8 Conserved Protein HJW72_01555 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HJW72_01560 ENOG4105WCN acetyltransferase HJW72_01570 ENOG4105D9R oxidoreductase HJW72_01575 ENOG4105C2I pirin domain protein HJW72_01580 ENOG4105DIQ Transcriptional regulator HJW72_01585 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HJW72_01590 ENOG4105C6Z Gluconate HJW72_01600 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HJW72_01605 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HJW72_01610 ENOG4108IUM Glycogen debranching enzyme HJW72_01615 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HJW72_01620 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HJW72_01625 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HJW72_01630 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HJW72_01635 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HJW72_01640 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HJW72_01645 ENOG4105E98 transcriptional regulator DeoR family HJW72_01650 ENOG41061ZR Transcriptional regulator HJW72_01655 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HJW72_01660 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HJW72_01665 ENOG4105C6Z Gluconate HJW72_01670 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HJW72_01675 ENOG4105MJ2 Competence protein HJW72_01680 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HJW72_01690 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HJW72_01695 ENOG4105CE1 Ferrous iron transport protein b HJW72_01700 ENOG4105XFK Ferrous iron transport protein A HJW72_01705 ENOG4105BZM domain protein HJW72_01710 ENOG4108RRZ Transcription elongation factor GreB HJW72_01720 ENOG4105E0F Histidine kinase HJW72_01735 ENOG4105VEJ Heat shock protein HJW72_01740 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HJW72_01745 ENOG4105DQY intracellular growth attenuator HJW72_01750 ENOG4107RK2 ADP-ribose diphosphatase NudE HJW72_01755 ENOG4108JQC penicillin-binding protein 1A HJW72_01780 ENOG4105E4G Type IV pilus HJW72_01785 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HJW72_01790 ENOG4105D49 3-dehydroquinate synthase HJW72_01795 ENOG4105EGB membrane protein DamX HJW72_01800 ENOG4105DFE Dna adenine methylase HJW72_01805 ENOG4105DJV ribulose-phosphate 3-epimerase HJW72_01815 ENOG4105C31 Tryptophanyl-tRNA synthetase HJW72_01820 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HJW72_01825 ENOG4105WZK nitrite reductase NADPH small subunit HJW72_01830 ENOG4107QZF nitrite reductase NADPH large subunit HJW72_01840 ENOG4105DZC cytosine deaminase HJW72_01845 ENOG4106DTQ Protein TsgA homolog HJW72_01850 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HJW72_01855 ENOG4106195 uncharacterized protein yhfG HJW72_01860 ENOG4105MZU cell filamentation protein HJW72_01870 ENOG4105C8Y Acetylornithine aminotransferase HJW72_01875 ENOG410613R integral membrane protein, YccS YhfK family HJW72_01880 ENOG4107RYR Transcriptional regulator, Crp Fnr family HJW72_01885 ENOG4108UKZ OsmC family HJW72_01890 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HJW72_01895 ENOG4105YP7 UPF0270 protein HJW72_01900 ENOG4105DNZ Alpha Beta Hydrolase HJW72_01910 ENOG4105C5H ABC transporter HJW72_01915 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HJW72_01925 ENOG4105VKU nucleicacid-binding protein HJW72_01930 ENOG4108YZY peptidylprolyl cis-trans isomerase HJW72_01935 ENOG4105VRX Protein slyX homolog HJW72_01940 ENOG4108V1T peptidylprolyl cis-trans isomerase HJW72_01945 ENOG4105WWK YheO domain protein HJW72_01950 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HJW72_01955 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HJW72_01960 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HJW72_01965 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HJW72_01970 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HJW72_01975 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HJW72_01980 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HJW72_01985 ENOG4105W53 bacterioferritin-associated ferredoxin HJW72_01990 ENOG4108UQY Iron-storage protein HJW72_02005 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HJW72_02010 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HJW72_02020 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HJW72_02025 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HJW72_02030 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HJW72_02035 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HJW72_02040 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HJW72_02045 ENOG41083MP 50s ribosomal protein l29 HJW72_02050 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HJW72_02055 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HJW72_02060 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HJW72_02075 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HJW72_02080 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HJW72_02090 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HJW72_02095 ENOG4105VPB 50S ribosomal protein L30 HJW72_02100 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HJW72_02105 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HJW72_02110 ENOG41067V7 50S ribosomal protein L36 HJW72_02115 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HJW72_02120 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HJW72_02125 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HJW72_02130 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HJW72_02135 ENOG4108ZT0 50S ribosomal protein l17 HJW72_02140 ENOG4105VTS DnaJ-like, subfamily C HJW72_02145 ENOG4105W1Y Transcriptional regulator HJW72_02150 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HJW72_02155 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HJW72_02160 ENOG4105C1A potassium transporter peripheral membrane HJW72_02165 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HJW72_02170 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HJW72_02175 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HJW72_02180 ENOG4105C79 DNA protecting protein DprA HJW72_02190 ENOG4108WI1 Dna topoisomerase HJW72_02195 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HJW72_02200 ENOG4105E2X shikimate dehydrogenase HJW72_02205 ENOG4105SG3 Protein of unknown function (DUF1488) HJW72_02210 ENOG4108Z0R Transferase HJW72_02240 ENOG4105XCM membrane LIPOPROTEIN HJW72_02245 ENOG4105BZS acriflavin resistance protein HJW72_02250 ENOG4105C1P efflux transporter, rnd family, mfp subunit HJW72_02255 ENOG4108XG4 DNA-binding transcriptional regulator HJW72_02265 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HJW72_02270 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HJW72_02275 ENOG4108IA2 Sodium pantothenate symporter HJW72_02280 ENOG4105RG0 Membrane HJW72_02285 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HJW72_02290 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HJW72_02300 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HJW72_02315 ENOG41062P1 Diguanylate cyclase phosphodiesterase HJW72_02325 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HJW72_02330 ENOG4105VQ7 Rod shape-determining protein MreD HJW72_02335 ENOG4108Z03 MAF-like protein HJW72_02340 ENOG4105C03 ribonuclease HJW72_02345 ENOG4105QD6 exported protein HJW72_02350 ENOG4105D1U peptidase U62 modulator of DNA gyrase HJW72_02355 ENOG4105CR8 Transcriptional regulator HJW72_02370 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HJW72_02375 ENOG4105UNR (Barnase) inhibitor HJW72_02380 ENOG4105RID UPF0379 protein yhcN HJW72_02385 ENOG4105RID UPF0379 protein yhcN HJW72_02390 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HJW72_02395 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HJW72_02410 ENOG4105C8P )-transporter HJW72_02415 ENOG4106DSS Tartrate dehydratase subunit alpha HJW72_02420 ENOG4107GFK fumarate HJW72_02430 ENOG4107QSA Oxaloacetate decarboxylase HJW72_02435 ENOG4105D9Q decarboxylase (Beta subunit) HJW72_02445 ENOG4105C0H protease HJW72_02450 ENOG4105C0H protease HJW72_02455 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HJW72_02460 ENOG4105D6Z AFG1 family ATPase HJW72_02465 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HJW72_02480 ENOG4107MKT Stringent starvation protein a HJW72_02485 ENOG4105KB2 stringent starvation protein b HJW72_02490 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HJW72_02495 ENOG4105BZ8 glutamate synthase HJW72_02500 ENOG4105CBC glutamate synthase HJW72_02505 ENOG4105N5T Radical SAM Protein HJW72_02510 ENOG4108I5G Major Facilitator superfamily HJW72_02515 ENOG4105CPQ Dehydrogenase HJW72_02525 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HJW72_02530 ENOG4105BZU Histidine kinase HJW72_02535 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HJW72_02545 ENOG41080Z8 PHOSPHOCARRIER protein HJW72_02550 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HJW72_02555 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HJW72_02560 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HJW72_02565 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HJW72_02570 ENOG4108IUZ ABC transporter HJW72_02575 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HJW72_02580 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HJW72_02585 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HJW72_02590 ENOG4105C2X Arabinose 5-phosphate isomerase HJW72_02595 ENOG4105FEU K -dependent Na -Ca exchanger HJW72_02600 ENOG4105DHJ ABC, transporter HJW72_02605 ENOG4105CY3 ABC transporter, permease HJW72_02610 ENOG4107PE3 Mammalian cell entry related domain protein HJW72_02615 ENOG4105E3I toluene tolerance HJW72_02620 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HJW72_02625 ENOG4105VFK BolA family HJW72_02630 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HJW72_02635 ENOG4105HVQ Regulatory factor of maltose metabolism HJW72_02640 ENOG4105EAH synthase HJW72_02645 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HJW72_02650 ENOG4105K46 50S ribosomal protein l27 HJW72_02655 ENOG4105QYV Membrane HJW72_02660 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HJW72_02665 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HJW72_02670 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HJW72_02675 ENOG4105HBR Rna-binding protein HJW72_02680 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HJW72_02685 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HJW72_02690 ENOG4105EEI dihydropteroate synthase HJW72_02695 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HJW72_02700 ENOG4105NTZ Preprotein translocase subunit SecG HJW72_02715 ENOG4108UII YfaZ family HJW72_02720 ENOG4108PNB DNA-binding transcriptional regulator HJW72_02725 ENOG4105CDH Citrulline--aspartate ligase HJW72_02740 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HJW72_02745 ENOG4105CHV Transcription elongation factor NusA HJW72_02750 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HJW72_02755 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HJW72_02760 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HJW72_02765 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HJW72_02770 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HJW72_02785 ENOG4105C1J atp-dependent rna helicase HJW72_02790 ENOG4105CIC tryptophan-specific transport protein HJW72_02795 ENOG4105DEN Luciferase family HJW72_02815 ENOG4108YYD acetyltransferase HJW72_02820 ENOG41082IR Excinuclease ABC C subunit domain protein HJW72_02825 ENOG4108ZPB UPF0306 protein HJW72_02830 ENOG4107R7Y intracellular protease Pfpi family HJW72_02835 ENOG4105K4T epimerase HJW72_02840 ENOG4107S21 permease HJW72_02845 ENOG4105W4M Transport-associated protein HJW72_02850 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HJW72_02855 ENOG41082RQ UPF0102 protein HJW72_02860 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HJW72_02865 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HJW72_02870 ENOG4105CTX dehydratase HJW72_02880 ENOG4105DJB Major Facilitator Superfamily HJW72_02885 ENOG4105CNV Aldolase HJW72_02890 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HJW72_02895 ENOG4105BZW Glycerate kinase HJW72_02920 ENOG4106D80 Uncharacterized protein YhaL HJW72_02925 ENOG4108CNN domain protein HJW72_02930 ENOG4105CWB LysR family transcriptional Regulator HJW72_02935 ENOG4105KAF membrAne HJW72_02940 ENOG4105CHF Glutathione S-transferase HJW72_02945 ENOG4108VBZ doxx family HJW72_02950 ENOG4105YJD HJW72_02955 ENOG41090KG Inner membrane protein YqjE HJW72_02960 ENOG4105NE1 Conserved Protein HJW72_02965 ENOG4105WAY exported protein HJW72_02970 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HJW72_02975 ENOG4106W5V Membrane HJW72_02980 ENOG4107YCY Transcriptional regulator HJW72_02985 ENOG4105DPW Major facilitator superfamily MFS_1 HJW72_02995 ENOG4105CTX dehydratase HJW72_03000 ENOG4105P66 Membrane HJW72_03005 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HJW72_03010 ENOG4105DU1 integral membrane protein, terc HJW72_03015 ENOG4105EE0 oxidoreductase HJW72_03020 ENOG4108VKG metal-dependent hydrolase HJW72_03040 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HJW72_03045 ENOG4107RYS Autoinducer-2 (AI-2) kinase HJW72_03050 ENOG4105DKT Transcriptional regulator HJW72_03055 ENOG4105C2J ABC transporter HJW72_03060 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HJW72_03065 ENOG4105F5R ABC transporter HJW72_03070 ENOG4105D4B ABC, transporter HJW72_03075 ENOG41061GT Aldolase HJW72_03080 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HJW72_03085 ENOG4105C8Y Acetylornithine aminotransferase HJW72_03090 ENOG4105NTW Transcriptional regulator HJW72_03100 ENOG4105Q26 Siderophore-interacting protein HJW72_03115 ENOG4108UTZ Dihydroxyacetone kinase HJW72_03120 ENOG4105CMT Dihydroxyacetone kinase HJW72_03150 ENOG4105C0A alcohol dehydrogenase HJW72_03165 ENOG4105YCI dehydratase medium subunit HJW72_03170 ENOG4108ZFT Dehydratase small subunit HJW72_03175 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HJW72_03180 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HJW72_03185 ENOG4105XXV Acid-resistance protein HJW72_03190 ENOG4108YK4 Acid-resistance membrane protein HJW72_03195 ENOG4108V08 YfdX protein HJW72_03200 ENOG4105BZU Histidine kinase HJW72_03205 ENOG4108WQH regulatoR HJW72_03260 ENOG4108RQP Major type 1 subunit fimbrin HJW72_03265 ENOG4108S54 Fimbrial protein HJW72_03270 ENOG4108NAE Fimbrial chaperone protein HJW72_03290 ENOG4108SQA Fimbrial HJW72_03295 ENOG4108T65 Fimbrial HJW72_03300 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HJW72_03305 ENOG4105BZU Histidine kinase HJW72_03320 ENOG4105MZU cell filamentation protein HJW72_03340 ENOG4108P8R HJW72_03345 ENOG4105JXR Protein of unknown function (DUF3296) HJW72_03390 ENOG4105C4R Atp-dependent dna helicase HJW72_03410 ENOG4105TS0 gtp-binding protein HJW72_03415 ENOG4106H6R UPF0380 protein HJW72_03420 ENOG4108KZE transcriptional regulator HJW72_03425 ENOG4105F4K antigen 43 HJW72_03430 ENOG4106ZN7 UPF0401 protein YkfF HJW72_03440 ENOG4108XS9 dna repair protein HJW72_03445 ENOG4105ZS6 Protein of unknown function (DUF987) HJW72_03450 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HJW72_03455 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HJW72_03470 ENOG4108VCA G U mismatch-specific DNA glycosylase HJW72_03475 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HJW72_03480 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HJW72_03490 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HJW72_03500 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HJW72_03505 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HJW72_03510 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HJW72_03515 ENOG4105CQM Urea amidohydrolase subunit alpha HJW72_03520 ENOG4105KI2 Urea amidohydrolase subunit beta HJW72_03525 ENOG4108YZ9 Urea amidohydrolase subunit gamma HJW72_03530 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HJW72_03545 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HJW72_03550 ENOG4107ZVW dihydroneopterin aldolase HJW72_03555 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HJW72_03560 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HJW72_03565 ENOG4106MWK domain protein HJW72_03570 ENOG4105I7R Adenylate cyclase HJW72_03575 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HJW72_03580 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HJW72_03595 ENOG4105W0Z cytoplasmic protein HJW72_03610 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HJW72_03615 ENOG4106032 Glutathionylspermidine synthase HJW72_03620 ENOG4105F1G UPF0441 protein HJW72_03630 ENOG41087AY ADP-Ribose pyrophosphatase HJW72_03635 ENOG4108SX3 cytoplasmic protein HJW72_03640 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HJW72_03645 ENOG4105IPS esterase HJW72_03650 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HJW72_03655 ENOG4105VRH Antibiotic biosynthesis monooxygenase HJW72_03660 ENOG4105NF4 modulator of drug activity HJW72_03665 ENOG4105DHQ Histidine kinase HJW72_03670 ENOG4105XJC Two component transcriptional regulator (Winged helix family HJW72_03675 ENOG4105H4F exported protein HJW72_03680 ENOG4105F4I Transcriptional regulator HJW72_03685 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HJW72_03690 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HJW72_03695 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HJW72_03700 ENOG4105CCT upf0313 protein HJW72_03710 ENOG4105CV8 reductase HJW72_03715 ENOG4108I6A alcohol dehydrogenase HJW72_03720 ENOG4105CF7 AraC family transcriptional regulator HJW72_03725 ENOG4108K81 inner membrane protein YghB HJW72_03730 ENOG4105C28 cystathionine HJW72_03735 ENOG4105CWK Biopolymer transport protein, ExbB HJW72_03740 ENOG4108ZZF transport protein (ExbD) HJW72_03745 ENOG4105CT4 transporter HJW72_03750 ENOG4105E4I Glycoside hydrolase family 28 HJW72_03755 ENOG4108TEB UPF0114 protein HJW72_03765 ENOG410900S Protein of unknown function (DUF2623) HJW72_03770 ENOG4105CYM Glutathione S-transferase HJW72_03785 ENOG4106032 Glutathionylspermidine synthase HJW72_03790 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HJW72_03810 ENOG4105CC0 LysR family Transcriptional regulator HJW72_03815 ENOG4105C28 cystathionine HJW72_03830 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HJW72_03845 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HJW72_03850 ENOG4108VCD Chaperone HJW72_03855 ENOG4105CW0 outer membrane usher protein HJW72_03880 ENOG4108UQV Membrane HJW72_03885 ENOG4105CXN decarboxylase HJW72_03890 ENOG4105EAA nucleoside HJW72_03895 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HJW72_03900 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HJW72_03905 ENOG4105CEN a g-specific adenine glycosylase HJW72_03910 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HJW72_03915 ENOG41090ED Protein with unknown function (DUF469) HJW72_03920 ENOG4105K33 Periplasmic Protein HJW72_03925 ENOG4108HWW ABC transporter HJW72_03930 ENOG4105C2J ABC transporter HJW72_03940 ENOG4105CSA Coproporphyrinogen iii oxidase HJW72_03945 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HJW72_03950 ENOG4105VZ9 UPF0235 protein HJW72_03955 ENOG4108VIA integral membrane protein HJW72_03960 ENOG4105DFA alanine racemase domain protein HJW72_03965 ENOG4105CZX twitching motility protein HJW72_03975 ENOG41086KC Transcriptional regulator HJW72_03980 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HJW72_03985 ENOG4108UJU UPF0301 protein HJW72_03990 ENOG4105D7Z glutathione synthase HJW72_03995 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HJW72_04000 ENOG4105RWS endonuclease I HJW72_04005 ENOG4105GPY SprT protein HJW72_04010 ENOG4107QNK )-transporter HJW72_04015 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HJW72_04035 ENOG4105CYW agmatinase HJW72_04040 ENOG41090KI Outer membrane porin HJW72_04045 ENOG4108K0D peptidase, M48 HJW72_04050 ENOG4105CV1 Transketolase (EC 2.2.1.1) HJW72_04055 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HJW72_04065 ENOG4105D2N Aldolase HJW72_04070 ENOG4105D64 Mechanosensitive ion channel HJW72_04075 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HJW72_04080 ENOG4105MPN Membrane HJW72_04085 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HJW72_04090 ENOG4105E66 phosphoriboisomerase A HJW72_04100 ENOG4108JQ1 Dehydrogenase HJW72_04105 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HJW72_04115 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HJW72_04120 ENOG4105E07 UPF0149 protein HJW72_04125 ENOG4107RAQ aminopeptidase HJW72_04130 ENOG4105D0A hydroxylase HJW72_04135 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HJW72_04140 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HJW72_04145 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HJW72_04155 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HJW72_04160 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HJW72_04180 ENOG4105CS2 ec 3.2.1.21 HJW72_04185 ENOG4108Q3X Transcriptional regulator HJW72_04190 ENOG4105N5Z UPF0267 protein HJW72_04195 ENOG4108UT2 hemolysin iii HJW72_04205 ENOG4105Y75 tpr repeat protein HJW72_04210 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HJW72_04215 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HJW72_04220 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HJW72_04225 ENOG4105T95 Thiol disulfide interChange protein HJW72_04230 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HJW72_04240 ENOG4105CRK lysyL-tRNA synthetase HJW72_04245 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HJW72_04250 ENOG4108UQV Membrane HJW72_04255 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HJW72_04260 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HJW72_04265 ENOG4106P55 Transcriptional regulator HJW72_04270 ENOG4108K5P (LipO)protein HJW72_04280 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJW72_04295 ENOG4105CPC Aldo Keto reductase HJW72_04310 ENOG4105W7K Transcriptional regulator HJW72_04335 ENOG4107R5R arsenical pump membrane protein HJW72_04340 ENOG4105K89 arsenate reductase HJW72_04345 ENOG4105DUX Transporter HJW72_04350 ENOG4105V2F Uncharacterized protein yoac HJW72_04355 ENOG4105ETP RND efflux system, outer membrane lipoprotein HJW72_04360 ENOG4108MI0 Resistance protein HJW72_04365 ENOG4105J12 Multidrug resistance protein mdtN HJW72_04375 ENOG4105VR1 Pfam:DUF1271 HJW72_04380 ENOG410830R acetyltransferase HJW72_04390 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HJW72_04395 ENOG4108T65 Fimbrial HJW72_04400 ENOG4108SQA Fimbrial HJW72_04405 ENOG4105CW0 outer membrane usher protein HJW72_04410 ENOG4108NAE Fimbrial chaperone protein HJW72_04415 ENOG4108S54 Fimbrial protein HJW72_04420 ENOG4108RQP Major type 1 subunit fimbrin HJW72_04425 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HJW72_04430 ENOG4108W9T type 1 fimbriae regulatory protein HJW72_04435 ENOG4105D7X high-affinity nickel-transporter HJW72_04440 ENOG4108ZT1 Transcriptional regulator HJW72_04445 ENOG4108KTG Membrane protein, drug metabolite transporter HJW72_04455 ENOG4108T1W Fimbrial subunit type 3 HJW72_04495 ENOG4107S5I aldo keto reductase HJW72_04500 ENOG4108MHD transport protein HJW72_04510 ENOG4105C5Q Transcriptional regulator HJW72_04515 ENOG4105CHU acetyl-coa acetyltransferase HJW72_04520 ENOG4108QGT oligogalacturonate-specific porin HJW72_04525 ENOG4105CAZ oligogalacturonide lyase HJW72_04535 ENOG4105CHR reductase HJW72_04540 ENOG4107QNK )-transporter HJW72_04545 ENOG4106NDP Transcriptional regulator HJW72_04555 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HJW72_04560 ENOG4108HKT sucrose-6-phosphate hydrolase HJW72_04575 ENOG4108IJ9 (ABC) transporter HJW72_04585 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HJW72_04590 ENOG4105YKW HJW72_04600 ENOG4105RQF LysR family Transcriptional regulator HJW72_04610 ENOG4105DDV Transcriptional regulator (LacI family HJW72_04615 ENOG4105CK1 PTS System HJW72_04620 ENOG4105CS2 ec 3.2.1.21 HJW72_04625 ENOG4107YCY Transcriptional regulator HJW72_04635 ENOG41060NJ transcriptional regulator HJW72_04640 ENOG4105CEY Amp-dependent synthetase and ligase HJW72_04645 ENOG4107S74 Lysophospholipid transporter LplT HJW72_04650 ENOG4105CPC Aldo Keto reductase HJW72_04655 ENOG4105SUV lipoprotein YgdR HJW72_04660 ENOG4105EE5 Membrane protein terC HJW72_04665 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) HJW72_04675 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HJW72_04680 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HJW72_04685 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HJW72_04690 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HJW72_04695 ENOG4105IPU prepilin peptidase dependent protein A HJW72_04700 ENOG4105JCS prepilin peptidase dependent protein HJW72_04705 ENOG4105SEN Protein of unknown function (DUF2509) HJW72_04710 ENOG4105RVB Prepilin peptidase dependent protein c HJW72_04715 ENOG4105DSY exodeoxyribonuclease V, gamma HJW72_04720 ENOG4107QXK peptidase HJW72_04725 ENOG4107QKA exodeoxyribonuclease V beta HJW72_04730 ENOG4107QYX exodeoxyribonuclease v alpha HJW72_04740 ENOG4107QZM n-acetylglutamate synthase HJW72_04745 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HJW72_04750 ENOG4107QZB decarboxylase HJW72_04755 ENOG4105JZC GHMP kinase HJW72_04760 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HJW72_04765 ENOG4105KTW ethanolamine utilization protein HJW72_04770 ENOG4105M3W utilization protein HJW72_04780 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HJW72_04785 ENOG4105C0A alcohol dehydrogenase HJW72_04790 ENOG4108EKI Dehydrogenase HJW72_04800 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HJW72_04815 ENOG4105KNY Microcompartments protein HJW72_04820 ENOG4105KNY Microcompartments protein HJW72_04830 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HJW72_04835 ENOG4108ZFT Dehydratase small subunit HJW72_04840 ENOG4105YCI dehydratase medium subunit HJW72_04845 ENOG4105DMB glycerol dehydratase HJW72_04850 ENOG4105EHR propanediol utilization protein pduB HJW72_04855 ENOG4105KNY Microcompartments protein HJW72_04860 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HJW72_04865 ENOG4107XVH Transcriptional regulator HJW72_04870 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HJW72_04875 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HJW72_04880 ENOG41081F0 Precorrin-8x methylmutase HJW72_04885 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HJW72_04890 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HJW72_04895 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HJW72_04900 ENOG4105CIA precorrin-4 C(11)-methyltransferase HJW72_04905 ENOG4108P62 biosynthesis protein (CbiG) HJW72_04910 ENOG4105E4R Precorrin-3B C17-methyltransferase HJW72_04915 ENOG4105QUC reductase HJW72_04920 ENOG4107PPM cobalt chelatase HJW72_04925 ENOG4105DVK Precorrin-2 c20-methyltransferase HJW72_04930 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HJW72_04935 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HJW72_04940 ENOG4108V4M Cobalt abc transporter HJW72_04950 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HJW72_04955 ENOG4108YZT Adenosylcobinamide kinase HJW72_05020 ENOG4108ZG0 Ompa motb domain protein HJW72_05055 ENOG4105CA3 membrane-bound lytic murein transglycosylase HJW72_05060 ENOG4105CUZ uba thif-type nad fad binding protein HJW72_05065 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HJW72_05070 ENOG4105C9B Cysteine desulfurase HJW72_05075 ENOG4105M5B (LipO)protein HJW72_05080 ENOG4105ETT transcriptional Regulator, LysR family HJW72_05085 ENOG4105M08 Membrane HJW72_05095 ENOG4107EDW L-fucose operon activator HJW72_05100 ENOG4105NWF RbsD or FucU transport HJW72_05105 ENOG4105CMG Carbohydrate kinase HJW72_05110 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HJW72_05115 ENOG4105EDR glucose galactose transporter HJW72_05125 ENOG4107W7X Aldolase HJW72_05130 ENOG4105C0A alcohol dehydrogenase HJW72_05135 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease HJW72_05140 ENOG4108JU7 Transcriptional regulator HJW72_05150 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HJW72_05165 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HJW72_05170 ENOG4108UMI ABC transporter, permease HJW72_05175 ENOG4105D01 (LipO)protein HJW72_05180 ENOG41079KZ Major Facilitator Superfamily HJW72_05190 ENOG4105GVF (ABC) transporter HJW72_05195 ENOG4105EJQ L-serine dehydratase HJW72_05200 ENOG4105C44 Serine transporter HJW72_05205 ENOG4105EWT decarboxylase family HJW72_05210 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HJW72_05215 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HJW72_05220 ENOG4105WP7 tRNA pseudouridine synthase C HJW72_05225 ENOG4105DR9 pseudouridine synthase HJW72_05230 ENOG4105QDK Flavodoxin HJW72_05235 ENOG4105DJB Major Facilitator Superfamily HJW72_05240 ENOG4105EQX glucarate dehydratase HJW72_05245 ENOG4105EQX glucarate dehydratase HJW72_05250 ENOG4105BZW Glycerate kinase HJW72_05255 ENOG4105BZU Histidine kinase HJW72_05260 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HJW72_05265 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HJW72_05270 ENOG4105DXN mazG family HJW72_05275 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HJW72_05280 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HJW72_05295 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HJW72_05300 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HJW72_05305 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HJW72_05310 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HJW72_05315 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HJW72_05320 ENOG4108MXK alkaline phosphatase isozyme conversion HJW72_05325 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HJW72_05330 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HJW72_05340 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HJW72_05345 ENOG4105N0Z inner membrane protein ygbE HJW72_05350 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HJW72_05355 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HJW72_05360 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HJW72_05365 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HJW72_05375 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HJW72_05380 ENOG4108K5P (LipO)protein HJW72_05385 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HJW72_05410 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HJW72_05415 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HJW72_05420 ENOG4105KZM cytoplasmic protein HJW72_05430 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HJW72_05455 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HJW72_05460 ENOG4105EHG Permease protein HJW72_05465 ENOG4107R4I Periplasmic binding protein HJW72_05470 ENOG4106QJH hemin transport protein HJW72_05490 ENOG4108N2Y auxin Efflux HJW72_05500 ENOG4105VXR cytoplasmic protein HJW72_05505 ENOG4105CC5 ABC transporter HJW72_05510 ENOG4105CC5 ABC transporter HJW72_05515 ENOG4105DIK (ABC) transporter HJW72_05520 ENOG4105DSE periplasmic solute binding protein HJW72_05525 ENOG4105DDV Transcriptional regulator (LacI family HJW72_05530 ENOG4105DKQ ROK family HJW72_05535 ENOG4105VCP PTS System HJW72_05540 ENOG4105CK1 PTS System HJW72_05545 ENOG4105VZJ PTS System HJW72_05550 ENOG4105CK1 PTS System HJW72_05555 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJW72_05565 ENOG4105CS2 ec 3.2.1.21 HJW72_05575 ENOG4105C45 hydrogenase expression formation protein (HypE) HJW72_05580 ENOG4105CQS hydrogenase expression formation protein HypD HJW72_05585 ENOG41083WG hydrogenase assembly chaperone HJW72_05590 ENOG4107RSS Hydrogenase accessory protein HypB HJW72_05595 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HJW72_05600 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HJW72_05605 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HJW72_05610 ENOG4107R30 NADH dehydrogenase HJW72_05615 ENOG4107TDF Formate hydrogenlyase subunit 4 HJW72_05620 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJW72_05625 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HJW72_05630 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HJW72_05635 ENOG4105I6X formate hydrogenlyase maturation HJW72_05640 ENOG4108MG9 hydrogenase 3 maturation protease HJW72_05650 ENOG4105CS2 ec 3.2.1.21 HJW72_05655 ENOG4105C5Y PTS System HJW72_05665 ENOG4105DDV Transcriptional regulator (LacI family HJW72_05670 ENOG4108RC0 Electron transport protein HJW72_05675 ENOG4105C8H hydrogenase maturation protein Hypf HJW72_05685 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HJW72_05690 ENOG4105CNW domain protein HJW72_05700 ENOG4108JUA Transcriptional regulator HJW72_05710 ENOG410804X Transcriptional regulator HJW72_05715 ENOG4105J92 DNA-binding transcriptional activator GutM HJW72_05720 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HJW72_05725 ENOG4105VI0 Pts system, glucitol sorbitol-specific HJW72_05730 ENOG4105DZY Pts system, glucitol sorbitol-specific HJW72_05735 ENOG410787A Pts system, glucitol sorbitol-specific HJW72_05740 ENOG4105CVE Lytic murein transglycosylase HJW72_05750 ENOG4105CC5 ABC transporter HJW72_05760 ENOG4107TH8 cina domain protein HJW72_05765 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HJW72_05770 ENOG4105Y3E Modulates RecA activity (By similarity) HJW72_05775 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HJW72_05780 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HJW72_05815 ENOG4105K3G Periplasmic Protein HJW72_05820 ENOG4107VXZ Hydrolase HJW72_05825 ENOG4105W39 Membrane HJW72_05830 ENOG4105D9M gamma-glutamylcysteine synthetase HJW72_05845 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HJW72_05850 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJW72_05855 ENOG4105CW7 secretion protein, HlyD family HJW72_05865 ENOG4105NTK Transcriptional repressor Mpra HJW72_05875 ENOG4105ZED uncharacterized protein ygaH HJW72_05880 ENOG4108UMN azlc family HJW72_05885 ENOG4105GIJ Glycine betaine HJW72_05890 ENOG4108HQS Glycine betaine HJW72_05895 ENOG4108IJ7 Glycine betaine HJW72_05900 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HJW72_05905 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HJW72_05910 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HJW72_05915 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HJW72_05920 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HJW72_05925 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HJW72_05930 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HJW72_05935 ENOG4108WMJ Protein of unknown function (DUF2002) HJW72_05940 ENOG4108RNS Exports L-alanine (By similarity) HJW72_05950 ENOG4108X73 DNA- binding protein HJW72_05965 ENOG4108V62 Rhodanese domain protein HJW72_05970 ENOG41080HT Transcriptional regulator, arsr family HJW72_05980 ENOG4105CC0 LysR family Transcriptional regulator HJW72_05985 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HJW72_05990 ENOG4105C26 Dehydrogenase HJW72_05995 ENOG4105X0I Fimbrial HJW72_06000 ENOG4108VCD Chaperone HJW72_06005 ENOG4105CW0 outer membrane usher protein HJW72_06020 ENOG4105CW0 outer membrane usher protein HJW72_06025 ENOG4106P2F Pfam:Pili_assembly_C HJW72_06030 ENOG4106EAR Fimbrial protein HJW72_06035 ENOG4108WQH regulatoR HJW72_06050 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HJW72_06055 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HJW72_06060 ENOG4105MP9 class II Aldolase HJW72_06070 ENOG4106TNF Periplasmic binding protein HJW72_06085 ENOG4105CYW agmatinase HJW72_06090 ENOG4105EVZ LysR family transcriptional regulator HJW72_06105 ENOG4105C1P efflux transporter, rnd family, mfp subunit HJW72_06110 ENOG4105UEI Transcriptional Regulator AraC Family HJW72_06135 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HJW72_06140 ENOG4108Z1B Cyclase dehydrase HJW72_06150 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HJW72_06160 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HJW72_06165 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HJW72_06170 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HJW72_06175 ENOG4108JU6 CBS domain protein HJW72_06180 ENOG4106KVJ cytochrome C assembly protein HJW72_06185 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HJW72_06190 ENOG4105K5M 30s ribosomal protein S16 HJW72_06195 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HJW72_06200 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HJW72_06205 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HJW72_06225 ENOG41090EK ompa motb domain protein HJW72_06230 ENOG4108KHX Diguanylate cyclase HJW72_06235 ENOG4108WS1 HJW72_06240 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HJW72_06245 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HJW72_06255 ENOG4105CQC Prephenate dehydratase HJW72_06265 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HJW72_06270 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HJW72_06275 ENOG4105C34 Pseudouridine synthase HJW72_06280 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HJW72_06285 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HJW72_06310 ENOG4105CSH Transporter HJW72_06315 ENOG4105T42 (LipO)protein HJW72_06320 ENOG4105JIM Phosphatidylserine synthase HJW72_06325 ENOG4105CD5 CoA-binding domain protein HJW72_06330 ENOG4106IUH DTW domain containing protein HJW72_06335 ENOG4105K63 Thioredoxin HJW72_06340 ENOG4105EIB trna rrna methyltransferase HJW72_06345 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HJW72_06350 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HJW72_06355 ENOG4105C1J atp-dependent rna helicase HJW72_06360 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HJW72_06365 ENOG4108IYU L-aspartate oxidase HJW72_06380 ENOG41069PW sigma-e factor negative regulatory protein HJW72_06385 ENOG4105VQK sigma E regulatory protein, MucB RseB HJW72_06390 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HJW72_06395 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HJW72_06400 ENOG4105C3F Signal peptidase i HJW72_06405 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HJW72_06410 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HJW72_06415 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HJW72_06420 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HJW72_06425 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HJW72_06430 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HJW72_06435 ENOG4106G6Q Transcriptional regulator HJW72_06440 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HJW72_06445 ENOG4108Z6B deaminase HJW72_06450 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HJW72_06455 ENOG4108ETH Formylglycinamide ribotide synthetase HJW72_06460 ENOG4107WP9 Histidine kinase HJW72_06465 ENOG4108SKK alpha helix protein HJW72_06470 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HJW72_06475 ENOG4108YZA Nitrogen regulatory protein pii HJW72_06480 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HJW72_06485 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HJW72_06490 ENOG4108SB3 DoxX Family HJW72_06495 ENOG4108NZE NAGC-like transcriptional regulator HJW72_06500 ENOG4107HQ7 repeat protein HJW72_06505 ENOG4107QNK )-transporter HJW72_06510 ENOG4108ZKT aldose 1-epimerase HJW72_06515 ENOG4105D8G Major Facilitator superfamily HJW72_06520 ENOG4108MN2 Stationary phase inducible protein CsiE HJW72_06525 ENOG41065CD Exported protein HJW72_06530 ENOG4105D7X high-affinity nickel-transporter HJW72_06540 ENOG4105ECY inositol monophosphatase HJW72_06545 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HJW72_06550 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HJW72_06555 ENOG4105C3J Cysteine desulfurase HJW72_06560 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HJW72_06565 ENOG4108Z4V iron-sulfur cluster assembly HJW72_06570 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HJW72_06575 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HJW72_06580 ENOG4108ZIT Ferredoxin, 2FE-2S HJW72_06585 ENOG4105WVQ Fe-S assembly protein IscX HJW72_06590 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HJW72_06595 ENOG4105YYA enhanced serine sensitivity protein SseB HJW72_06605 ENOG4105KHC sulfurtransferase HJW72_06610 ENOG4105DN3 alpha-2-macroglobulin domain protein HJW72_06615 ENOG4108JQB penicillin-binding protein 1C HJW72_06620 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HJW72_06625 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HJW72_06630 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HJW72_06635 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HJW72_06645 ENOG4105N21 Membrane HJW72_06650 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HJW72_06655 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HJW72_06665 ENOG4105VPD cellular component movement HJW72_06670 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HJW72_06675 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HJW72_06680 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HJW72_06690 ENOG4105C4X radical SAM domain protein HJW72_06705 ENOG41062G3 Protein of unknown function (DUF2633) HJW72_06710 ENOG4105BZU Histidine kinase HJW72_06715 ENOG4105C9X ppx gppa phosphatase HJW72_06720 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HJW72_06725 ENOG4108V3E phosphoribosylglycinamide formyltransferase HJW72_06730 ENOG4105CXB phosphoribosylaminoimidazole synthetase HJW72_06735 ENOG41066F8 ROK family HJW72_06740 ENOG4105CS2 ec 3.2.1.21 HJW72_06745 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HJW72_06750 ENOG4105C2W permease HJW72_06755 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HJW72_06765 ENOG4105K89 arsenate reductase HJW72_06770 ENOG4105ERG peptidase m48, ste24p HJW72_06780 ENOG4105C02 permease HJW72_06785 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HJW72_06790 ENOG4105RH4 Glycine cleavage system transcriptional repressor HJW72_06795 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HJW72_06800 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HJW72_06805 ENOG4105C8V SAICAR synthetase HJW72_06810 ENOG4105CGZ zinc metallopeptidase HJW72_06815 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HJW72_06820 ENOG4106KED esterase YpfH HJW72_06825 ENOG4105XYK UPF0370 protein HJW72_06830 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HJW72_06835 ENOG4105KUZ arsenate reductase HJW72_06845 ENOG4105BZS acriflavin resistance protein HJW72_06850 ENOG4105BZ8 glutamate synthase HJW72_06855 ENOG4107VIJ nudix hydrolase HJW72_06860 ENOG4108PVD exported protein HJW72_06865 ENOG4105CV1 Transketolase (EC 2.2.1.1) HJW72_06870 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HJW72_06875 ENOG4105C6K Malic enzyme HJW72_06880 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HJW72_06885 ENOG4106S4J ethanolamine utilization protein EutP HJW72_06890 ENOG4105NDK ethanolamine utilization protein HJW72_06895 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HJW72_06900 ENOG4108IJ2 phosphate acetyltransferase HJW72_06905 ENOG4105KNY Microcompartments protein HJW72_06910 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HJW72_06915 ENOG4108EKI Dehydrogenase HJW72_06920 ENOG4107YMV ethanolamine utilization protein HJW72_06925 ENOG4105C0A alcohol dehydrogenase HJW72_06930 ENOG4105ENY Ethanolamine utilization protein eutH HJW72_06935 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HJW72_06940 ENOG4105CPD ethanolamine ammonia-lyase HJW72_06950 ENOG4106D67 ethanolamine utilization protein HJW72_06955 ENOG4108X49 Ethanolamine utilization protein EutK HJW72_06960 ENOG4108K3Z AraC family transcriptional regulator HJW72_06965 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HJW72_06970 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HJW72_06975 ENOG4108R6G acetyltransferase HJW72_06980 ENOG4105QZU Inner membrane protein YfeZ HJW72_06985 ENOG4105E7K (LipO)protein HJW72_06990 ENOG4105EZR dyp-type peroxidase family protein HJW72_07000 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HJW72_07005 ENOG4108I5D sulfate abc transporter HJW72_07010 ENOG4105ECW sulfate abc transporter HJW72_07015 ENOG4108IJ6 ABC transporter HJW72_07020 ENOG4105C6T cysteine synthase HJW72_07025 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HJW72_07030 ENOG4105CSW GntR family transcriptional regulator HJW72_07035 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HJW72_07045 ENOG4105C5Y PTS System HJW72_07050 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HJW72_07055 ENOG4105KZ7 phosphocarrier protein hpr HJW72_07065 ENOG4105C6T cysteine synthase HJW72_07070 ENOG4105EXN Sulfate transport protein CysZ HJW72_07075 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HJW72_07080 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HJW72_07085 ENOG4105VRT cytoplasmic protein HJW72_07090 ENOG4105DHU Bile acid HJW72_07095 ENOG4108M0I Transcriptional regulator HJW72_07120 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HJW72_07125 ENOG4105GXM Putative transcription regulator (DUF1323) HJW72_07130 ENOG4105HZG regulatoR HJW72_07145 ENOG4108KMM Diguanylate cyclase HJW72_07150 ENOG4105D9N nucleoside HJW72_07155 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HJW72_07160 ENOG4109076 Conserved Protein HJW72_07165 ENOG4105CPC Aldo Keto reductase HJW72_07170 ENOG4107RA9 decarboxylase HJW72_07180 ENOG4105CHC glucokinase (EC 2.7.1.2) HJW72_07185 ENOG4105DY9 regulatoR HJW72_07190 ENOG4108HRK Histidine kinase HJW72_07205 ENOG4105CHM Aminotransferase HJW72_07215 ENOG4105DJ2 Major Facilitator Superfamily HJW72_07220 ENOG4107Y2X deaminase HJW72_07225 ENOG4105DND Transcriptional regulator HJW72_07245 ENOG4105S64 Formate nitrite transporter HJW72_07250 ENOG410903C (LipO)protein HJW72_07255 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HJW72_07260 ENOG4105KZW UPF0381 protein HJW72_07265 ENOG4105CHU acetyl-coa acetyltransferase HJW72_07270 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HJW72_07275 ENOG4108BY2 phosphohistidine phosphatase HJW72_07280 ENOG4108DG9 Smr protein MutS2 HJW72_07285 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HJW72_07290 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HJW72_07295 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HJW72_07300 ENOG4105EJ9 Membrane HJW72_07305 ENOG4108BPE -transporting atpase HJW72_07310 ENOG4105MH2 YfcL protein HJW72_07315 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HJW72_07320 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HJW72_07325 ENOG4105F9N Major Facilitator Superfamily HJW72_07330 ENOG4106WZ1 flagella biosynthesis regulator HJW72_07340 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HJW72_07345 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HJW72_07350 ENOG4105DQR SNARE associated Golgi HJW72_07355 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HJW72_07360 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HJW72_07365 ENOG4108S3P Sporulation domain protein HJW72_07370 ENOG4105E96 Colicin v production protein HJW72_07375 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HJW72_07380 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HJW72_07390 ENOG4105E89 ABC transporter HJW72_07395 ENOG4105E89 ABC transporter HJW72_07400 ENOG4105DSP amino acid AbC transporter HJW72_07405 ENOG4106YG3 ABC transporter HJW72_07410 ENOG4108JEH abc transporter atp-binding protein HJW72_07415 ENOG4105KNA -acetyltransferase HJW72_07425 ENOG4105ECP epimerase HJW72_07430 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HJW72_07435 ENOG4105CYM Glutathione S-transferase HJW72_07440 ENOG4108SHQ Glutathione S-transferase HJW72_07445 ENOG4108RE9 Phosphodiesterase HJW72_07450 ENOG4105PTV Nudix Hydrolase HJW72_07455 ENOG4105C6K Malic enzyme HJW72_07460 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HJW72_07465 ENOG4105PQ6 UPF0208 membrane protein HJW72_07475 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HJW72_07480 ENOG4107QWE )-transporter HJW72_07485 ENOG4105DK2 UPF0207 protein HJW72_07490 ENOG4105CHM Aminotransferase HJW72_07495 ENOG4107NQ8 LysR family Transcriptional regulator HJW72_07505 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HJW72_07510 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJW72_07515 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJW72_07520 ENOG4105GKE subunit e HJW72_07525 ENOG4107QIZ NADH dehydrogenase HJW72_07530 ENOG4108IEH NADH dehydrogenase subunit g HJW72_07535 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HJW72_07545 ENOG4107UFS subunit j HJW72_07550 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJW72_07555 ENOG4105D65 subunit l HJW72_07560 ENOG4105C8S subunit m HJW72_07565 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HJW72_07570 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HJW72_07575 ENOG4107YB6 acetyltransferase, (GNAT) family HJW72_07580 ENOG4105E4F Isochorismate synthase HJW72_07585 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HJW72_07590 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HJW72_07595 ENOG4108IPT Naphthoate synthase HJW72_07600 ENOG4105DNI Converts SHCHC to OSB (By similarity) HJW72_07605 ENOG4105CEY Amp-dependent synthetase and ligase HJW72_07615 ENOG4105DNE Transposase HJW72_07625 ENOG4108UII YfaZ family HJW72_07630 ENOG4108EWA cinA-like protein HJW72_07635 ENOG4107258 Transcriptional regulator HJW72_07640 ENOG4105CXK mandelate racemase muconate lactonizing HJW72_07645 ENOG4105CSP Major Facilitator Superfamily HJW72_07650 ENOG4105CNV Aldolase HJW72_07655 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HJW72_07660 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HJW72_07665 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HJW72_07670 ENOG4105CXY transporter HJW72_07675 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HJW72_07680 ENOG4105XPH Ferredoxin HJW72_07685 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HJW72_07690 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HJW72_07695 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HJW72_07700 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HJW72_07705 ENOG4105BZU Histidine kinase HJW72_07710 ENOG41068CG regulatoR HJW72_07715 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HJW72_07730 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HJW72_07735 ENOG4105CF1 Alkylated DNA repair protein HJW72_07740 ENOG4105IBP Cyclic peptide transporter HJW72_07745 ENOG4105CJW magnesium transporter HJW72_07750 ENOG4105CHH sulfate transporter HJW72_07765 ENOG4105F4G Membrane HJW72_07825 ENOG4105DFP Integrase HJW72_07835 ENOG4105E68 Sulfatase HJW72_07840 ENOG4105PAN UPF0352 protein HJW72_07845 ENOG4106V8H Nucleoid-associated protein HJW72_07850 ENOG4105N2W Transcriptional regulator HJW72_07855 ENOG4107VIJ nudix hydrolase HJW72_07870 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HJW72_07875 ENOG4105CFI type iii restriction protein res subunit HJW72_07880 ENOG4105I08 Pseudouridine synthase HJW72_07885 ENOG4105C2C drug resistance transporter, Bcr CflA HJW72_07890 ENOG4105HG6 HJW72_07895 ENOG4108JQ5 ABC transporter HJW72_07900 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HJW72_07905 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HJW72_07910 ENOG4105E43 Extracellular solute-binding protein, family 5 HJW72_07915 ENOG4105CXC rtn protein HJW72_07920 ENOG4107TT5 NLP P60 protein HJW72_07925 ENOG41076MN Phosphoesterase, PA-phosphatase related HJW72_07930 ENOG4105CKI cobalamin synthesis protein HJW72_07935 ENOG4105DEI Mannitol dehydrogenase HJW72_07940 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HJW72_07950 ENOG4105KRS Proteinase inhibitor HJW72_07955 ENOG4105S8Q sugar efflux transporter HJW72_07960 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HJW72_07965 ENOG4105DE4 1-phosphofructokinase HJW72_07970 ENOG4105DM4 PTS System HJW72_07975 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HJW72_07980 ENOG4105HMI Membrane HJW72_07985 ENOG4105DUM transcriptional regulator, lysR family HJW72_07990 ENOG4108IQI permease HJW72_07995 ENOG4105D05 Receptor HJW72_08005 ENOG4105EUJ GTP cyclohydrolase i HJW72_08010 ENOG4105DHF Membrane HJW72_08015 ENOG41060NJ transcriptional regulator HJW72_08025 ENOG4105C2J ABC transporter HJW72_08030 ENOG4107SDZ Galactoside transport system permease protein mglC HJW72_08035 ENOG4107GZ4 SanA protein HJW72_08040 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HJW72_08045 ENOG41067MG lrgb family HJW72_08050 ENOG4105VAW lrga family HJW72_08055 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HJW72_08060 ENOG4105TW1 Carbohydrate-selective porin OprB HJW72_08075 ENOG4105CS2 ec 3.2.1.21 HJW72_08090 ENOG4105KHU inner membrane protein YohD HJW72_08095 ENOG41069YE inner membrane protein yohC HJW72_08100 ENOG41061WM D-Alanyl-D-Alanine HJW72_08110 ENOG4105CXG d-lactate dehydrogenase HJW72_08115 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HJW72_08120 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HJW72_08125 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HJW72_08130 ENOG4108IJ8 ABC transporter HJW72_08135 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HJW72_08145 ENOG4108HRK Histidine kinase HJW72_08150 ENOG4108NEV two component transcriptional regulator, LytTR family HJW72_08155 ENOG4108W15 Protein of unknown function (DUF1456) HJW72_08160 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HJW72_08165 ENOG4105D1F ATP-binding protein HJW72_08175 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HJW72_08180 ENOG4105EJC lysr family transcriptional regulator HJW72_08185 ENOG4105C7N Xanthine uracil vitamin C permease HJW72_08190 ENOG4105CPN adenine deaminase HJW72_08195 ENOG4105DUM transcriptional regulator, lysR family HJW72_08210 ENOG4105DWF phosphomethylpyrimidine kinase HJW72_08215 ENOG4105EIE fructose-bisphosphate aldolase HJW72_08220 ENOG4105IE8 Alpha-ketoglutarate permease HJW72_08245 ENOG4105DEI Mannitol dehydrogenase HJW72_08250 ENOG4105CMG Carbohydrate kinase HJW72_08255 ENOG4105IE8 Alpha-ketoglutarate permease HJW72_08260 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HJW72_08270 ENOG4105CFP Peptidase U32 HJW72_08275 ENOG4105E3W Two component transcriptional regulator (Winged helix family HJW72_08280 ENOG4105EB3 Histidine kinase HJW72_08285 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJW72_08290 ENOG4105BZS acriflavin resistance protein HJW72_08295 ENOG4105BZS acriflavin resistance protein HJW72_08300 ENOG4105ENT Efflux transporter rnd family, mfp subunit HJW72_08305 ENOG4105CK2 sodium dicarboxylate symporter HJW72_08325 ENOG4105BZU Histidine kinase HJW72_08330 ENOG4105R8A Heat shock protein HJW72_08335 ENOG4105D03 DNA-3-methyladenine glycosylase II HJW72_08340 ENOG4105DBI uridine monophosphokinase HJW72_08345 ENOG4105DHP deoxycytidine triphosphate deaminase HJW72_08350 ENOG4108GAE asmA family HJW72_08355 ENOG4105EE5 Membrane protein terC HJW72_08360 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HJW72_08365 ENOG4105MH5 phosphoesterase PA-phosphatase related protein HJW72_08380 ENOG4108MRJ HJW72_08385 ENOG4105DAY polysaccharide export protein HJW72_08425 ENOG4107STW synthase HJW72_08445 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HJW72_08515 ENOG4105CPK Glycosyl transferase (Group 1 HJW72_08525 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HJW72_08530 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HJW72_08540 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HJW72_08545 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HJW72_08550 ENOG4105CIH Imidazole acetol-phosphate transaminase HJW72_08560 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HJW72_08570 ENOG4107SRH Nad-dependent epimerase dehydratase HJW72_08575 ENOG4105EQ1 Transcriptional regulator HJW72_08585 ENOG4105CUB amino acid HJW72_08590 ENOG4105YVS arsR family transcriptional regulator HJW72_08595 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HJW72_08600 ENOG4105CJB Exodeoxyribonuclease I HJW72_08605 ENOG4105DZ1 carboxypeptidase HJW72_08615 ENOG4105DR8 Membrane HJW72_08620 ENOG41090HJ UPF0265 protein HJW72_08625 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HJW72_08630 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HJW72_08635 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HJW72_08645 ENOG41090U3 tautomerase HJW72_08650 ENOG4105HEI LysR family (Transcriptional regulator HJW72_08655 ENOG4108KMH lipoate-protein ligase a HJW72_08660 ENOG4105CSH Transporter HJW72_08670 ENOG4105BZU Histidine kinase HJW72_08675 ENOG4108YS1 cytoplasmic protein HJW72_08680 ENOG4105YP6 Domain of unknown function (DUF1869) HJW72_08685 ENOG4105ETT transcriptional Regulator, LysR family HJW72_08700 ENOG4105BZU Histidine kinase HJW72_08715 ENOG4105CVR type I restriction-modification system HJW72_08780 ENOG4108PCE TRANSFER protein HJW72_08815 ENOG4106D0Q Type IV secretion system protein VirB2 HJW72_08860 ENOG4107ZSV Receptor HJW72_08865 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HJW72_08885 ENOG4105C0W non-ribosomal peptide synthetase HJW72_08900 ENOG4105BZ1 (ABC) transporter HJW72_08905 ENOG4105EYM Major Facilitator superfamily HJW72_08930 ENOG4105UQX Mate efflux family protein HJW72_08940 ENOG4105FYV Amp nucleosidase HJW72_08960 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HJW72_08965 ENOG4108WUH Transcriptional regulator, TetR family HJW72_08970 ENOG4105EEQ Na H antiporter HJW72_08990 ENOG4107R11 Transcriptional regulator HJW72_08995 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HJW72_09015 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HJW72_09095 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HJW72_09100 ENOG4108MXB Protein of unknown function (DUF968) HJW72_09125 ENOG4105NVB glycoside hydrolase, family 19 HJW72_09175 ENOG4105CAR Terminase, large subunit HJW72_09185 ENOG4105EFC phage portal protein HK97 family HJW72_09240 ENOG41064PC HJW72_09300 ENOG4105FCK Membrane HJW72_09310 ENOG4105Y0K Inner membrane protein YedR HJW72_09315 ENOG4105EST Metal Dependent Phosphohydrolase HJW72_09320 ENOG4105DVF Cytosine-specific methyltransferase HJW72_09325 ENOG41090BB DNA mismatch endonuclease (vsr) HJW72_09330 ENOG4105FDR Membrane HJW72_09335 ENOG4105CKW Inner membrane protein yedI HJW72_09345 ENOG4105YX3 cellular response to acidity HJW72_09360 ENOG4105JCU Inherit from NOG: (Lipo)protein HJW72_09365 ENOG4105E5K Alpha-amylase HJW72_09370 ENOG4105EAB amino acid AbC transporter HJW72_09375 ENOG4105K6H D-cysteine desulfhydrase HJW72_09380 ENOG4105E5Q amino acid AbC transporter HJW72_09385 ENOG4105CDA abc transporter atp-binding protein HJW72_09390 ENOG4105VJY transcriptional regulator HJW72_09395 ENOG4105XVG cytoplasmic protein HJW72_09400 ENOG4105WH1 Two component transcriptional regulator luxr family HJW72_09435 ENOG4106RHG Yeca family HJW72_09440 ENOG4105E0U tyrosine-specific transport protein HJW72_09445 ENOG4105VVZ metal-binding protein HJW72_09450 ENOG41090A1 ferritin HJW72_09465 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJW72_09470 ENOG4105N4N Protein of unknown function (DUF2766) HJW72_09485 ENOG4108UEC Ferritin-like protein HJW72_09495 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HJW72_09505 ENOG4105CNN ABC, transporter HJW72_09515 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HJW72_09520 ENOG4108VA4 Universal stress protein HJW72_09525 ENOG4105CT4 transporter HJW72_09530 ENOG4105F5H Glycosyl Hydrolase Family 88 HJW72_09535 ENOG4105C75 arginyL-tRNA synthetase HJW72_09540 ENOG4106ZCM YecM protein HJW72_09545 ENOG4106N3A copper homeostasis protein cutc HJW72_09550 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HJW72_09555 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HJW72_09560 ENOG4105WJG Glutathione HJW72_09565 ENOG41081XQ Conserved Protein HJW72_09570 ENOG4105D3W isochorismatase HJW72_09575 ENOG4105C9M aspartyl-trna synthetase HJW72_09580 ENOG4108TIT dATP pyrophosphohydrolase HJW72_09585 ENOG4105CDY transcriptional regulatory protein HJW72_09590 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HJW72_09595 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HJW72_09600 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HJW72_09605 ENOG4105FAV ABC, transporter HJW72_09615 ENOG4105NXV High-affinity zinc uptake system protein HJW72_09620 ENOG4105DR5 peptidase HJW72_09625 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HJW72_09630 ENOG4105CA9 Pyruvate kinase HJW72_09635 ENOG4106KNT transcriptional regulator HJW72_09645 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HJW72_09650 ENOG4105C01 Dihydroxy-acid dehydratase HJW72_09655 ENOG4108UHU Aldolase HJW72_09665 ENOG4105X2V dna damage-inducible protein HJW72_09670 ENOG4108Q2J Inner membrane protein YebE HJW72_09675 ENOG4105CUG Oligopeptidase b HJW72_09680 ENOG4105UMD exodeoxyribonuclease X HJW72_09685 ENOG4105MPK DNA polymerase III subunit theta HJW72_09690 ENOG4105FXM Copper resistance protein HJW72_09695 ENOG4108PNC copper resistance HJW72_09700 ENOG4105NKT exported protein HJW72_09710 ENOG4108MJ5 VirK protein HJW72_09715 ENOG4108R1E Serine threonine protein phosphatase 1 HJW72_09720 ENOG4105UVW uncharacterized protein yebW HJW72_09725 ENOG4105WT8 Protein of unknown function (DUF1480) HJW72_09730 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HJW72_09735 ENOG4105DY2 Paraquat-inducible protein b HJW72_09740 ENOG4105H2K paraquat-inducible protein a HJW72_09745 ENOG4108ZGC gaf domain protein HJW72_09750 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HJW72_09755 ENOG4105CN1 protease HJW72_09760 ENOG4105D0M Protease HtpX homolog HJW72_09765 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJW72_09770 ENOG4105J4Q Transcriptional regulator HJW72_09775 ENOG4105TIK HJW72_09785 ENOG4105Q3Y exported protein HJW72_09805 ENOG4105CJN penicillin-binding protein HJW72_09810 ENOG4105DHI Methyltransferase HJW72_09815 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HJW72_09820 ENOG4108NK4 UPF0266 membrane protein HJW72_09825 ENOG4105F3R pts system mannose fructose sorbose family iid HJW72_09830 ENOG4105ETZ PTS System HJW72_09835 ENOG4105DAS pts system HJW72_09840 ENOG4105EE5 Membrane protein terC HJW72_09845 ENOG4107XTP (EAL) domain protein HJW72_09855 ENOG4105EJQ L-serine dehydratase HJW72_09860 ENOG4105P8F nudix hydrolase HJW72_09870 ENOG4105X5C UPF0181 protein HJW72_09875 ENOG4105M4H endoribonuclease L-psp HJW72_09880 ENOG4105DVT helicase HJW72_09885 ENOG41072GX Peptidase M22 Glycoprotease HJW72_09890 ENOG4105Y4Z Outer Membrane Lipoprotein HJW72_09895 ENOG4105CEY Amp-dependent synthetase and ligase HJW72_09900 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HJW72_09905 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HJW72_09910 ENOG4107QMS site-determining protein HJW72_09915 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HJW72_09920 ENOG4105VNG YcgL domain-containing protein HJW72_09925 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HJW72_09930 ENOG4108ZZ3 UPF0260 protein HJW72_09940 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HJW72_09945 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HJW72_09950 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) HJW72_09955 ENOG4105ED1 spovr family HJW72_09965 ENOG4105MWK D-amino acid dehydrogenase, small subunit HJW72_09975 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HJW72_09980 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HJW72_09985 ENOG4106JQ5 Transglycosylase SLT domain HJW72_09990 ENOG4105E0K tonB-dependent siderophore receptor HJW72_10050 ENOG410811B TRANSCRIPTIONal HJW72_10055 ENOG4105C7B Threonine dehydratase HJW72_10060 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HJW72_10070 ENOG4105C6N Formate acetyltransferase HJW72_10085 ENOG4105C32 Amino acid ABC transporter (Permease) HJW72_10090 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HJW72_10095 ENOG4105C0Z ABC transporter HJW72_10100 ENOG4108IV0 ABC, transporter HJW72_10105 ENOG4107YNJ LysR family Transcriptional regulator HJW72_10125 ENOG4105CSH Transporter HJW72_10135 ENOG4105F04 LysR family Transcriptional regulator HJW72_10145 ENOG4105D3G Pseudouridine synthase HJW72_10150 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HJW72_10175 ENOG4108ZG0 Ompa motb domain protein HJW72_10265 ENOG4105C3G gtp-binding protein HJW72_10270 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HJW72_10275 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HJW72_10285 ENOG4105CHH sulfate transporter HJW72_10290 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HJW72_10295 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HJW72_10305 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HJW72_10310 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HJW72_10315 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HJW72_10320 ENOG4108YY7 Invasion gene expression up-regulator SirB HJW72_10325 ENOG41063JG Transcriptional regulator HJW72_10330 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HJW72_10335 ENOG4105EWV Sodium calcium exchanger membrane region HJW72_10340 ENOG4105WS7 Cation transport regulator HJW72_10345 ENOG4108NH8 Cation transport protein HJW72_10355 ENOG41090EX DsrE family HJW72_10370 ENOG4105I5W Transporter HJW72_10380 ENOG4105D7T ABC transporter HJW72_10385 ENOG4107QZF nitrite reductase NADPH large subunit HJW72_10395 ENOG4105ID0 Putative invasin HJW72_10400 ENOG4105WH1 Two component transcriptional regulator luxr family HJW72_10405 ENOG4105BZU Histidine kinase HJW72_10410 ENOG4105DQQ Major facilitator superfamily MFS_1 HJW72_10420 ENOG4105CRU nitrate reductase, alpha subunit HJW72_10425 ENOG4108IUE nitrate reductase beta subunit HJW72_10430 ENOG4105R3A Nitrate reductase HJW72_10435 ENOG41076YT nitrate reductase, gamma subunit HJW72_10485 ENOG4105CIY formyltetrahydrofolate deformylase HJW72_10495 ENOG4105D78 K07001 NTE family protein HJW72_10500 ENOG4105I93 response regulator HJW72_10505 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HJW72_10520 ENOG4107104 thymidine kinase HJW72_10525 ENOG4105C0A alcohol dehydrogenase HJW72_10535 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HJW72_10545 ENOG4108J59 Extracellular solute-binding protein, family 5 HJW72_10550 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJW72_10555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJW72_10560 ENOG4105C3U ABC transporter HJW72_10565 ENOG4108JQ7 (ABC) transporter HJW72_10570 ENOG4105EYW Ion transport protein HJW72_10575 ENOG4108W5H UPF0263 protein HJW72_10580 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HJW72_10590 ENOG4108YYC ycei family HJW72_10600 ENOG4105K9H YciI-like protein HJW72_10605 ENOG410822N TonB family HJW72_10615 ENOG4105P10 Uncharacterized protein ydiZ HJW72_10620 ENOG4105DE4 1-phosphofructokinase HJW72_10625 ENOG4108NE3 Salt-induced outer membrane protein HJW72_10640 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HJW72_10645 ENOG41082NX 50s ribosomal protein l35 HJW72_10660 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HJW72_10665 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HJW72_10670 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HJW72_10680 ENOG4105MWK D-amino acid dehydrogenase, small subunit HJW72_10685 ENOG4105RQF LysR family Transcriptional regulator HJW72_10695 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) HJW72_10700 ENOG4105D01 (LipO)protein HJW72_10705 ENOG4108V06 Glutathione peroxidase HJW72_10715 ENOG4108QBX (LipO)protein HJW72_10720 ENOG4105CNG UPF0061 protein HJW72_10730 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HJW72_10745 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HJW72_10755 ENOG4105IPI Membrane HJW72_10760 ENOG4105CQB FAD linked oxidase domain protein HJW72_10765 ENOG4105KA0 thioesterase Superfamily protein HJW72_10770 ENOG4105Y3U Transglycosylase-associated protein HJW72_10785 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HJW72_10795 ENOG4105E0A ABC, transporter HJW72_10800 ENOG4105EHG Permease protein HJW72_10810 ENOG4106KR7 LysR family Transcriptional regulator HJW72_10835 ENOG4105DMF Dehydrogenase HJW72_10840 ENOG4105KBX Transcriptional regulator, TetR family HJW72_10860 ENOG4108Z4V iron-sulfur cluster assembly HJW72_10865 ENOG4105DIW FeS assembly protein SUFB HJW72_10870 ENOG4105C3K feS assembly ATPase SufC HJW72_10875 ENOG4105JRK feS assembly protein SufD HJW72_10880 ENOG4105C9B Cysteine desulfurase HJW72_10885 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HJW72_10890 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HJW72_10900 ENOG4105CA9 Pyruvate kinase HJW72_10915 ENOG4105RFR Protein of unknown function (DUF2767) HJW72_10930 ENOG4105DJB Major Facilitator Superfamily HJW72_10935 ENOG4105E2X shikimate dehydrogenase HJW72_10940 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein HJW72_10945 ENOG4108W0P ABC transporter HJW72_10950 ENOG4105EHG Permease protein HJW72_10955 ENOG4105S10 periplasmic binding protein HJW72_10960 ENOG4108K2P TRANSCRIPTIONal HJW72_10965 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HJW72_10975 ENOG4107UB2 Alpha beta hydrolase fold HJW72_10980 ENOG4105IKQ hydratase HJW72_10990 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HJW72_10995 ENOG4108SC4 )-transporter HJW72_11010 ENOG4108T2C cysteine dioxygenase type I HJW72_11015 ENOG4105CR8 Transcriptional regulator HJW72_11020 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HJW72_11040 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HJW72_11045 ENOG4108IY8 ABC, transporter HJW72_11055 ENOG4105E0A ABC, transporter HJW72_11060 ENOG4105DQ5 transport system permease protein HJW72_11080 ENOG4106PMH Extracellular solute-binding protein family 3 HJW72_11085 ENOG4105E5Q amino acid AbC transporter HJW72_11090 ENOG4105CDA abc transporter atp-binding protein HJW72_11105 ENOG41083G8 Multidrug resistance protein MdtM HJW72_11130 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HJW72_11135 ENOG4105DG4 malate L-lactate dehydrogenase HJW72_11145 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HJW72_11150 ENOG4107Z33 ABC transporter, permease HJW72_11180 ENOG41060M0 Crispr-associated protein, cse4 family HJW72_11190 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HJW72_11195 ENOG4105PWE CRISPR-associated protein cas2 HJW72_11200 ENOG4105GMB type VI secretion system effector, hcp1 family HJW72_11230 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HJW72_11235 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HJW72_11240 ENOG41060IM Heme exporter protein HJW72_11250 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HJW72_11255 ENOG4105DA4 cytochrome c-type biogenesis protein HJW72_11260 ENOG4107QX9 Thiol disulfide interChange protein HJW72_11265 ENOG4105KWW Biogenesis protein HJW72_11290 ENOG4105CHR reductase HJW72_11295 ENOG4105C7K acetolactate synthase HJW72_11310 ENOG4105DTD Dehydrogenase HJW72_11315 ENOG4105CY2 Citrate transporter HJW72_11320 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HJW72_11325 ENOG4105CHU acetyl-coa acetyltransferase HJW72_11330 ENOG4107QNJ CoA-transferase subunit B HJW72_11340 ENOG4106NZI LysR family Transcriptional regulator HJW72_11360 ENOG4105CQB FAD linked oxidase domain protein HJW72_11365 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HJW72_11385 ENOG4105KME endoribonuclease L-psp HJW72_11390 ENOG4107TTD cytosine deaminase HJW72_11400 ENOG4105EMY transcriptional regulator HJW72_11430 ENOG4105CXC rtn protein HJW72_11445 ENOG4105EB3 Histidine kinase HJW72_11450 ENOG4105ENT Efflux transporter rnd family, mfp subunit HJW72_11455 ENOG4105BZS acriflavin resistance protein HJW72_11470 ENOG4105CXC rtn protein HJW72_11475 ENOG4105M5B (LipO)protein HJW72_11515 ENOG4105IE8 Alpha-ketoglutarate permease HJW72_11520 ENOG4107Z96 xylose isomerase HJW72_11540 ENOG4108RVA ribokinase HJW72_11570 ENOG4108JQ7 (ABC) transporter HJW72_11575 ENOG4105C3U ABC transporter HJW72_11600 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HJW72_11605 ENOG4105E98 transcriptional regulator DeoR family HJW72_11615 ENOG4107B2H carbonic anhydrase HJW72_11645 ENOG4105CY0 Metallo-Beta-Lactamase HJW72_11665 ENOG4105E1F short-chain dehydrogenase reductase HJW72_11695 ENOG4108URH decarboxylase HJW72_11705 ENOG4107QI1 Mate efflux family protein HJW72_11710 ENOG4108R6K riboflavin synthase, subunit alpha HJW72_11715 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HJW72_11720 ENOG4105CZQ inner membrane transport protein YdhC HJW72_11725 ENOG4105F52 Transcriptional regulator HJW72_11730 ENOG4105ETE Transcriptional regulator (LacI family HJW72_11740 ENOG4105F27 Major Facilitator HJW72_11745 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HJW72_11755 ENOG4105K4H Nlp p60 protein HJW72_11760 ENOG4105M2J Glutaredoxin HJW72_11765 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HJW72_11770 ENOG4108UYE Lactoylglutathione lyase HJW72_11775 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HJW72_11780 ENOG4108WUH Transcriptional regulator, TetR family HJW72_11785 ENOG4105XZD Fe-S protein HJW72_11790 ENOG4107RGM aldo keto reductase HJW72_11795 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HJW72_11800 ENOG4105DSW Fusaric acid resistance protein HJW72_11805 ENOG4105Y49 secretion protein, HlyD family HJW72_11820 ENOG4105BZU Histidine kinase HJW72_11825 ENOG4108XTF Outer Membrane Lipoprotein HJW72_11830 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HJW72_11835 ENOG410642K Lysozyme inhibitor HJW72_11840 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HJW72_11845 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HJW72_11850 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HJW72_11855 ENOG4108K3A Glutathione S-transferase HJW72_11865 ENOG4105CSM endonuclease III HJW72_11875 ENOG4108UQQ Electron transport complex HJW72_11900 ENOG4105M9B inner membrane protein ydgK HJW72_11910 ENOG4105CS2 ec 3.2.1.21 HJW72_11920 ENOG4105D9R oxidoreductase HJW72_11925 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HJW72_11930 ENOG4105EQ0 Major Facilitator superfamily HJW72_11950 ENOG4105CPW cytochrome b561 HJW72_11970 ENOG4105DDW LysR family Transcriptional regulator HJW72_11975 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HJW72_11980 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HJW72_11985 ENOG4105E32 cytoplasmic protein HJW72_11990 ENOG4105EBR Carboxylesterase HJW72_12005 ENOG4108Z9I -acetyltransferase HJW72_12010 ENOG4107WE3 acetyltransferase YdcK HJW72_12015 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HJW72_12020 ENOG41088CC tellurite resistance protein tehB HJW72_12025 ENOG4108KKZ (LipO)protein HJW72_12030 ENOG4108RNG Permease of the drug metabolite transporter HJW72_12035 ENOG4105UEI Transcriptional Regulator AraC Family HJW72_12040 ENOG4105DKK Benzoate HJW72_12045 ENOG4108JCI Transcriptional regulator HJW72_12055 ENOG4105CFP Peptidase U32 HJW72_12075 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HJW72_12080 ENOG4105C4M (Ubiquinol oxidase) subunit I HJW72_12085 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HJW72_12090 ENOG4107TYH extracellular solute-binding protein family 1 HJW72_12095 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HJW72_12100 ENOG4105D81 ABC transporter, permease HJW72_12105 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HJW72_12110 ENOG4105C26 Dehydrogenase HJW72_12135 ENOG410654E Membrane HJW72_12140 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HJW72_12155 ENOG4105DEF Extracellular solute-binding protein, family 5 HJW72_12160 ENOG4105R71 cytoplasmic protein HJW72_12165 ENOG4108T9Y Inner membrane protein ydcZ HJW72_12170 ENOG4108Z7F N-acetyltransferase HJW72_12180 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HJW72_12185 ENOG4105DU0 nucleoside hydrolase HJW72_12195 ENOG41065TG regulatoR HJW72_12200 ENOG4105CI2 imidazolone-5-propionate hydrolase HJW72_12205 ENOG4105CHB tonB-dependent Receptor HJW72_12210 ENOG4108NS2 receptor HJW72_12220 ENOG4105C85 amino acid HJW72_12225 ENOG4105EQ2 LysR family Transcriptional regulator HJW72_12235 ENOG4105DEN Luciferase family HJW72_12250 ENOG4105EAB amino acid AbC transporter HJW72_12260 ENOG4105DRP amino acid AbC transporter HJW72_12265 ENOG4105CDA abc transporter atp-binding protein HJW72_12275 ENOG4108N27 Glutathione S-transferase HJW72_12280 ENOG4105KZK Tautomerase pptA HJW72_12295 ENOG4105CT4 transporter HJW72_12310 ENOG4108MEJ flavin reductase domain protein HJW72_12315 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HJW72_12320 ENOG4105C4Y ABC transporter HJW72_12325 ENOG4107RCV ABC transporter, permease HJW72_12330 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HJW72_12335 ENOG4105D0D Nitrate reductase 2, gamma subunit HJW72_12340 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HJW72_12345 ENOG4108IUE nitrate reductase beta subunit HJW72_12350 ENOG4105CRU nitrate reductase, alpha subunit HJW72_12355 ENOG4107QND Nitrite extrusion protein HJW72_12370 ENOG4107HP6 Transcriptional regulator HJW72_12375 ENOG4105DTQ mandelate racemase muconate lactonizing HJW72_12380 ENOG4105NN7 muconolactone delta-isomerase HJW72_12385 ENOG410626B catechol 1,2-dioxygenase HJW72_12395 ENOG4108UKV benzoate 1,2-dioxygenase HJW72_12420 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HJW72_12425 ENOG4108MG3 formate dehydrogenase HJW72_12440 ENOG4105CSR polyphosphate kinase 2 HJW72_12450 ENOG4105F27 Major Facilitator HJW72_12465 ENOG4108JQ6 ABC transporter HJW72_12470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJW72_12485 ENOG4105DQ4 alcohol dehydrogenase HJW72_12500 ENOG4105C5H ABC transporter HJW72_12520 ENOG4107R1I NAD-dependent malic enzyme HJW72_12540 ENOG4105JQN Transcriptional regulator HJW72_12545 ENOG4105N0E Protein of unknown function (DUF2543) HJW72_12550 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HJW72_12565 ENOG4108N8X transition metal ion binding HJW72_12575 ENOG4105CG3 alpha amylase, catalytic region HJW72_12595 ENOG4108YDI single-species biofilm formation on inanimate substrate HJW72_12605 ENOG4108Z9K Osmotically inducible protein HJW72_12630 ENOG4105FFC UPF0187 protein HJW72_12635 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HJW72_12640 ENOG4105C5Q Transcriptional regulator HJW72_12645 ENOG4105CK1 PTS System HJW72_12670 ENOG4105VZJ PTS System HJW72_12675 ENOG4105VCP PTS System HJW72_12680 ENOG4108KUU Inner membrane metabolite transport protein ydjE HJW72_12685 ENOG4105KT7 mgtC SapB transporter HJW72_12690 ENOG4105D6Z AFG1 family ATPase HJW72_12695 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HJW72_12710 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HJW72_12715 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF HJW72_12720 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HJW72_12730 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) HJW72_12735 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HJW72_12745 ENOG4108IGT Dipeptidase HJW72_12750 ENOG4108J2P Alpha beta hydrolase fold HJW72_12760 ENOG4105E0F Histidine kinase HJW72_12775 ENOG4105DY8 decarboxylase HJW72_12780 ENOG4108JPW Aminotransferase HJW72_12785 ENOG4107Z6I Thiamine biosynthesis protein HJW72_12790 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HJW72_12795 ENOG4108YI8 ABC transporter HJW72_12800 ENOG4105ETU transcriptional activator (TenA HJW72_12815 ENOG4105CIB oxidoreductase Domain protein HJW72_12825 ENOG4105ETE Transcriptional regulator (LacI family HJW72_12830 ENOG4105BZU Histidine kinase HJW72_12835 ENOG4107QUY Guanine deaminase HJW72_12840 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HJW72_12875 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HJW72_12905 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HJW72_12930 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HJW72_12955 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HJW72_12975 ENOG4105E5Q amino acid AbC transporter HJW72_12985 ENOG4105C5R Aminotransferase HJW72_13000 ENOG4105CBN LysR family transcriptional regulator HJW72_13010 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HJW72_13015 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HJW72_13020 ENOG4105CSH Transporter HJW72_13050 ENOG4105FCD Major Facilitator HJW72_13060 ENOG4105ETE Transcriptional regulator (LacI family HJW72_13065 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HJW72_13075 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HJW72_13080 ENOG4105UP7 3-epimerase HJW72_13090 ENOG4108YRF PTS System HJW72_13095 ENOG4105DM4 PTS System HJW72_13100 ENOG410829K Lysine exporter protein (Lyse ygga) HJW72_13110 ENOG4105CBN LysR family transcriptional regulator HJW72_13115 ENOG4105HEI LysR family (Transcriptional regulator HJW72_13130 ENOG4107PP3 Acetylornithine deacetylase HJW72_13145 ENOG4105CNN ABC, transporter HJW72_13150 ENOG4105C2J ABC transporter HJW72_13155 ENOG4105ETE Transcriptional regulator (LacI family HJW72_13185 ENOG4109066 lysm domain bon superfamily protein HJW72_13190 ENOG4105CXY transporter HJW72_13195 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HJW72_13205 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta HJW72_13210 ENOG4105RHY Pfam:UPF0157 HJW72_13215 ENOG4105EQ2 LysR family Transcriptional regulator HJW72_13220 ENOG4105CPC Aldo Keto reductase HJW72_13230 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis HJW72_13235 ENOG4105CPC Aldo Keto reductase HJW72_13265 ENOG4105KME endoribonuclease L-psp HJW72_13270 ENOG4105DZ2 Transcriptional regulator HJW72_13275 ENOG4105C28 cystathionine HJW72_13280 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HJW72_13285 ENOG4105C44 Serine transporter HJW72_13290 ENOG4105CR8 Transcriptional regulator HJW72_13300 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HJW72_13305 ENOG4105C4M (Ubiquinol oxidase) subunit I HJW72_13315 ENOG4105K63 Thioredoxin HJW72_13345 ENOG4105ETT transcriptional Regulator, LysR family HJW72_13355 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HJW72_13360 ENOG4105CHR reductase HJW72_13365 ENOG4105CHU acetyl-coa acetyltransferase HJW72_13385 ENOG4105BZW Glycerate kinase HJW72_13390 ENOG4107VHA regulatoR HJW72_13400 ENOG4105JQN Transcriptional regulator HJW72_13410 ENOG4107YCY Transcriptional regulator HJW72_13415 ENOG4105CI1 PTS System HJW72_13420 ENOG4105F8D glycoside hydrolase family 4 HJW72_13430 ENOG4105C54 Major Facilitator superfamily HJW72_13435 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HJW72_13455 ENOG4105NIV Esterase HJW72_13460 ENOG4105BZU Histidine kinase HJW72_13475 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HJW72_13495 ENOG4108VCD Chaperone HJW72_13500 ENOG4105CW0 outer membrane usher protein HJW72_13510 ENOG4105F32 YngK protein HJW72_13515 ENOG4105CAF HipA N-terminal domain protein HJW72_13520 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HJW72_13525 ENOG4105VT2 5-hydroxyisourate hydrolase HJW72_13530 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HJW72_13535 ENOG4105C2W permease HJW72_13540 ENOG41061H0 Monooxygenase HJW72_13545 ENOG4108KSA LysR family transcriptional regulator HJW72_13565 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HJW72_13580 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HJW72_13590 ENOG4105D01 (LipO)protein HJW72_13600 ENOG4108UMI ABC transporter, permease HJW72_13605 ENOG4105EA8 2-Nitropropane dioxygenase HJW72_13615 ENOG4105EGI Transcriptional regulator HJW72_13620 ENOG4105CBP Major Facilitator HJW72_13630 ENOG4105F9N Major Facilitator Superfamily HJW72_13675 ENOG4107QZW Altronate oxidoreductase HJW72_13685 ENOG4105BZU Histidine kinase HJW72_13690 ENOG4105M0C cytoplasmic protein HJW72_13695 ENOG4105CSV Glutaminase HJW72_13700 ENOG4105C26 Dehydrogenase HJW72_13705 ENOG4105EGI Transcriptional regulator HJW72_13715 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HJW72_13720 ENOG4105MVE transcriptional regulator HJW72_13725 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HJW72_13730 ENOG4107S2N Type III effector Hrp-dependent HJW72_13735 ENOG4105C0A alcohol dehydrogenase HJW72_13740 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HJW72_13745 ENOG4108JQ1 Dehydrogenase HJW72_13755 ENOG4105JAB phenazine biosynthesis protein, phzf family HJW72_13760 ENOG4105F27 Major Facilitator HJW72_13765 ENOG41082NP Multiple antibiotic resistance HJW72_13775 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HJW72_13780 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HJW72_13785 ENOG4106DNR multiple antibiotic resistance protein HJW72_13790 ENOG4108594 Permease of the drug metabolite transporter HJW72_13795 ENOG4105E5W Transporter HJW72_13805 ENOG4108IV0 ABC, transporter HJW72_13815 ENOG4105CNN ABC, transporter HJW72_13820 ENOG4105C32 Amino acid ABC transporter (Permease) HJW72_13825 ENOG41083Z3 extracellular ligand-binding receptor HJW72_13840 ENOG4105ECQ AraC Family Transcriptional Regulator HJW72_13865 ENOG4105CNT hydrolase family 2 HJW72_13870 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HJW72_13875 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HJW72_13890 ENOG4105MVE transcriptional regulator HJW72_13900 ENOG4105G63 Type III effector Hrp-dependent HJW72_13905 ENOG4105FB2 class II Aldolase HJW72_13910 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HJW72_13915 ENOG4105C6Z Gluconate HJW72_13935 ENOG4105BZU Histidine kinase HJW72_13940 ENOG4108WTK competence damage-inducible protein HJW72_13945 ENOG4108ZNX Heat shock protein HJW72_13995 ENOG4108RAV Conserved protein HJW72_14000 ENOG4105R1U AraC Family Transcriptional Regulator HJW72_14010 ENOG4105DGW oligopeptidase A HJW72_14015 ENOG4105EMU Dehydrogenase HJW72_14020 ENOG4107XBN GntR Family Transcriptional Regulator HJW72_14025 ENOG4108U51 Universal stress protein HJW72_14030 ENOG4105DEI Mannitol dehydrogenase HJW72_14035 ENOG4108I5G Major Facilitator superfamily HJW72_14045 ENOG4105M5Q UPF0482 protein HJW72_14050 ENOG4108MK9 spermidine N(1)-acetyltransferase HJW72_14060 ENOG4105KBG Protein of unknown function (DUF1161) HJW72_14065 ENOG4107QY8 reductase HJW72_14070 ENOG4105QAX Iron-sulfur HJW72_14075 ENOG4107KGK dmso reductase anchor subunit HJW72_14080 ENOG4108NEM leader-binding protein dmsD HJW72_14085 ENOG4105CMQ Chloride channel HJW72_14090 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HJW72_14095 ENOG4105DAG ROK family HJW72_14100 ENOG4106NZI LysR family Transcriptional regulator HJW72_14105 ENOG4105D94 Major Facilitator Superfamily HJW72_14110 ENOG4105CTD carboxy-peptidase HJW72_14130 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HJW72_14140 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) HJW72_14145 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HJW72_14150 ENOG4105DSF transport protein HJW72_14180 ENOG4107TT2 Auxin Efflux Carrier HJW72_14185 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HJW72_14190 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HJW72_14195 ENOG4108K70 Transcriptional regulator HJW72_14200 ENOG4105DWT malate dehydrogenase (quinone) HJW72_14205 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HJW72_14215 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HJW72_14220 ENOG4108MRH transcriptional regulatory protein HJW72_14240 ENOG4107GFK fumarate HJW72_14250 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HJW72_14255 ENOG4105F2Z 3-oxoadipate enol-lactonase HJW72_14260 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HJW72_14265 ENOG4105CHU acetyl-coa acetyltransferase HJW72_14270 ENOG4107QNJ CoA-transferase subunit B HJW72_14280 ENOG4107HP6 Transcriptional regulator HJW72_14285 ENOG4108DG9 Smr protein MutS2 HJW72_14290 ENOG4106KR7 LysR family Transcriptional regulator HJW72_14300 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HJW72_14305 ENOG4105CFC Transporter HJW72_14315 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HJW72_14320 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HJW72_14325 ENOG4105Q9Y Universal stress protein HJW72_14330 ENOG410671Z uncharacterized protein ydiH HJW72_14335 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HJW72_14340 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HJW72_14355 ENOG4105C5D exported protein HJW72_14360 ENOG4105D5Q Arginine ornithine antiporter HJW72_14365 ENOG410642E Short chain dehydrogenase HJW72_14370 ENOG4105RA2 Membrane HJW72_14375 ENOG4107EXC regulatoR HJW72_14385 ENOG4105JJR Histidine kinase HJW72_14395 ENOG4105C9Q fumarate hydratase class II HJW72_14400 ENOG4107GFK fumarate HJW72_14405 ENOG4105EIP mannose-6-phosphate isomerase HJW72_14410 ENOG4106J39 exported protein HJW72_14415 ENOG4107P2S Transcriptional regulator HJW72_14420 ENOG4105CI1 PTS System HJW72_14425 ENOG4105C87 Aminotransferase class I and II HJW72_14435 ENOG41061EV selenium-binding protein YdfZ HJW72_14450 ENOG41066VF YeeE YedE family protein HJW72_14460 ENOG41064WM Uncharacterized protein YcgX HJW72_14465 ENOG4105VPI YqaE family transport protein HJW72_14470 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HJW72_14475 ENOG4105C26 Dehydrogenase HJW72_14485 ENOG4107DB1 DUF218 domain HJW72_14490 ENOG4105CSH Transporter HJW72_14500 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HJW72_14505 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HJW72_14510 ENOG4105C26 Dehydrogenase HJW72_14515 ENOG4105F4X arginine HJW72_14520 ENOG4105C8Y Acetylornithine aminotransferase HJW72_14530 ENOG4105D82 Glutamate dehydrogenase HJW72_14535 ENOG4108FN7 Aldo keto reductase HJW72_14540 ENOG410642W LysR family Transcriptional regulator HJW72_14560 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HJW72_14570 ENOG4105CQ7 ATP-dependent helicase HJW72_14575 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HJW72_14585 ENOG4108Z0R Transferase HJW72_14590 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HJW72_14595 ENOG4105DZS Phenylacetate-CoA ligase HJW72_14600 ENOG4105CHU acetyl-coa acetyltransferase HJW72_14605 ENOG4108ZJI phenylacetic acid degradation protein HJW72_14610 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HJW72_14615 ENOG4108UKI Enoyl-CoA hydratase HJW72_14620 ENOG4105E39 Enoyl-CoA hydratase HJW72_14625 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HJW72_14630 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HJW72_14635 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HJW72_14640 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HJW72_14645 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HJW72_14650 ENOG4105DXM phenylacetic acid degradation protein HJW72_14655 ENOG4105F11 amine oxidase HJW72_14670 ENOG4105C26 Dehydrogenase HJW72_14675 ENOG4108WFR AraC Family Transcriptional Regulator HJW72_14680 ENOG4105WXT Conserved Protein HJW72_14685 ENOG410689M (LipO)protein HJW72_14690 ENOG4107H52 Dicarboxylate transport HJW72_14695 ENOG4108KF1 Membrane HJW72_14700 ENOG4105C5I Dehydrogenase HJW72_14705 ENOG41090X5 Heat shock protein hslJ HJW72_14710 ENOG4105IKK cytoplasmic protein HJW72_14715 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HJW72_14720 ENOG4105FCK Membrane HJW72_14730 ENOG4108RW8 Universal stress protein F HJW72_14740 ENOG4105C1J atp-dependent rna helicase HJW72_14745 ENOG4107RX3 Mg2 transporter protein cora family protein HJW72_14750 ENOG4105E98 transcriptional regulator DeoR family HJW72_14755 ENOG4105D9R oxidoreductase HJW72_14770 ENOG4105C85 amino acid HJW72_14775 ENOG4105F7P transcriptional regulator AsnC family HJW72_14785 ENOG4105CGF Aromatic amino acid aminotransferase HJW72_14790 ENOG4108UMI ABC transporter, permease HJW72_14800 ENOG4105D01 (LipO)protein HJW72_14840 ENOG4105HEI LysR family (Transcriptional regulator HJW72_14865 ENOG4108XFH Transcriptional regulator HJW72_14870 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HJW72_14965 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HJW72_14975 ENOG4108ZG0 Ompa motb domain protein HJW72_15005 ENOG4108Z0Z intracellular protease Pfpi family HJW72_15020 ENOG4105CBN LysR family transcriptional regulator HJW72_15080 ENOG4105BZU Histidine kinase HJW72_15095 ENOG4107RTG Major Facilitator superfamily HJW72_15100 ENOG4105ENX hydrolase HJW72_15105 ENOG4105EQ2 LysR family Transcriptional regulator HJW72_15120 ENOG4107QSI ABC, transporter HJW72_15130 ENOG4105KXI murein peptide amidase A HJW72_15135 ENOG4107S8C mandelate racemase muconate lactonizing HJW72_15140 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HJW72_15145 ENOG4108KK1 membrane protein AbrB duplication HJW72_15150 ENOG4108JU8 Transcriptional regulator HJW72_15155 ENOG4105F8D glycoside hydrolase family 4 HJW72_15160 ENOG4105W8I Transcriptional regulator HJW72_15165 ENOG4106K28 UPF0283 membrane protein HJW72_15170 ENOG4105CM6 amino acid regulated cytosolic protein HJW72_15175 ENOG4105NNG Peripheral inner membrane phage-shock protein HJW72_15180 ENOG4105FM1 phage shock protein C HJW72_15185 ENOG4105YYT phage shock protein B HJW72_15190 ENOG41087YS Phage shock protein A HJW72_15195 ENOG4105E51 psp operon transcriptional activator HJW72_15205 ENOG4105CH2 amidohydrolase HJW72_15210 ENOG41063ZK Transcriptional Regulator AraC Family HJW72_15225 ENOG4108J59 Extracellular solute-binding protein, family 5 HJW72_15230 ENOG4108EKA peptide transport system, permease HJW72_15235 ENOG4108EU3 peptide transport system, permease HJW72_15240 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HJW72_15245 ENOG4108JQ2 peptide transport system atp-binding protein HJW72_15250 ENOG4105ETS cytosine purines uracil thiamine allantoin HJW72_15260 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HJW72_15265 ENOG4105Q4T oxidoreductase HJW72_15270 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HJW72_15280 ENOG4105N2W Transcriptional regulator HJW72_15290 ENOG41061RM osmotically inducible lipoprotein HJW72_15295 ENOG4108ZJT translation initiation factor, Sui1 HJW72_15305 ENOG4105CFV Tetratricopeptide repeat protein HJW72_15310 ENOG4105Q4A inner membrane protein yciS HJW72_15315 ENOG4105EYK Phosphatidylglycerophosphatase B HJW72_15320 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HJW72_15325 ENOG4107QM5 aconitate hydratase HJW72_15335 ENOG4107R11 Transcriptional regulator HJW72_15340 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HJW72_15345 ENOG4105RKX Protein of unknown function (DUF2498) HJW72_15350 ENOG4105ERU peptidase HJW72_15360 ENOG4105UBK short-chain dehydrogenase reductase HJW72_15365 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HJW72_15390 ENOG4105ETT transcriptional Regulator, LysR family HJW72_15400 ENOG4107RTD sua5 ycio yrdc ywlc family protein HJW72_15405 ENOG4105DB7 PHP domain protein HJW72_15410 ENOG4105CRQ synthase (Component I) HJW72_15415 ENOG4108EFP Anthranilate synthase component II HJW72_15420 ENOG4105DK0 Indole-3-glycerol phosphate synthase HJW72_15425 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HJW72_15430 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HJW72_15475 ENOG4108IU3 tonb-dependent siderophore receptor HJW72_15480 ENOG4107E2E PKHD-type hydroxylase HJW72_15485 ENOG4105EIF outer membrane protein W HJW72_15490 ENOG4105PI0 Ferredoxin HJW72_15495 ENOG4108S3I UPF0259 membrane protein HJW72_15500 ENOG4107835 probably involved in intracellular septation (By similarity) HJW72_15505 ENOG4107RNH Outer membrane receptor FepA HJW72_15510 ENOG4105NAU thioesterase Superfamily protein HJW72_15515 ENOG4107PN8 YfeABCD locus regulator HJW72_15520 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HJW72_15525 ENOG4105CHR reductase HJW72_15530 ENOG4107K5X Membrane-bound metal-dependent hydrolase HJW72_15535 ENOG4108ETY sodium dicarboxylate symporter HJW72_15540 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HJW72_15545 ENOG4105CH6 catalase HJW72_15550 ENOG410901P UPF0249 protein HJW72_15555 ENOG4105F8D glycoside hydrolase family 4 HJW72_15560 ENOG4105EZV Transcriptional regulator HJW72_15565 ENOG4105VCP PTS System HJW72_15570 ENOG4105CK1 PTS System HJW72_15580 ENOG4105VZJ PTS System HJW72_15585 ENOG4105KKI DNA-binding transcriptional activator OsmE HJW72_15595 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HJW72_15600 ENOG4108SPG Periplasmic Protein HJW72_15610 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HJW72_15615 ENOG4105C26 Dehydrogenase HJW72_15620 ENOG4105F4X arginine HJW72_15630 ENOG4105CGK Exodeoxyribonuclease III HJW72_15635 ENOG4108RSN SNARE associated Golgi HJW72_15640 ENOG4108N5C SNARE associated Golgi protein-related protein HJW72_15645 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HJW72_15650 ENOG4105VNH ABC transporter solute-binding protein HJW72_15655 ENOG4105CXZ ABC transporter, permease HJW72_15660 ENOG4108VGW abc transporter atp-binding protein HJW72_15665 ENOG4107RM6 sulfurtransferase HJW72_15670 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HJW72_15675 ENOG4105M6F mutator MutT protein HJW72_15680 ENOG4105D82 Glutamate dehydrogenase HJW72_15690 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HJW72_15695 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HJW72_15700 ENOG4105SBG acid phosphatase HJW72_15705 ENOG41069NU Nitroreductase HJW72_15710 ENOG4105D07 Signal peptide peptidase, SppA HJW72_15715 ENOG4105HDK L-asparaginase HJW72_15720 ENOG4108RWI nicotinamidase HJW72_15730 ENOG4105N1F Hnh endonuclease HJW72_15735 ENOG4105VUT cytoplasmic protein HJW72_15740 ENOG4105E0X reductase HJW72_15745 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HJW72_15750 ENOG4105DSB aldose 1-epimerase HJW72_15755 ENOG4105CV8 reductase HJW72_15760 ENOG4105GNX MltA-interacting MipA family protein HJW72_15765 ENOG4105CYN Serine protein kinase HJW72_15770 ENOG4106AKX UPF0229 protein HJW72_15780 ENOG4108V06 Glutathione peroxidase HJW72_15800 ENOG4105F27 Major Facilitator HJW72_15805 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HJW72_15810 ENOG4105CBN LysR family transcriptional regulator HJW72_15815 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HJW72_15820 ENOG4105KT5 UmuD protein HJW72_15825 ENOG4105Y50 Virulence Protein HJW72_15830 ENOG4108XNZ glycosyl transferase HJW72_15835 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HJW72_15840 ENOG4108VMM UPF0756 membrane protein HJW72_15845 ENOG4105R1U AraC Family Transcriptional Regulator HJW72_15850 ENOG4105DJ2 Major Facilitator Superfamily HJW72_15855 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HJW72_15860 ENOG4105EWC Purine nucleoside phosphorylase HJW72_15865 ENOG4105K78 MarR family Transcriptional regulator HJW72_15870 ENOG4105UCG Domain of unknown function (DUF333) HJW72_15875 ENOG4105ZTC transcriptional activator, Ogr delta HJW72_16005 ENOG4105ED4 portal protein HJW72_16035 ENOG4105DFE Dna adenine methylase HJW72_16080 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HJW72_16085 ENOG410620I Diguanylate cyclase HJW72_16090 ENOG4106G4W HJW72_16105 ENOG4105S5I Membrane HJW72_16110 ENOG4108NIW Leucine export protein LeuE HJW72_16115 ENOG4105D1S lipid A biosynthesis HJW72_16130 ENOG4105DHT Metal Dependent Phosphohydrolase HJW72_16135 ENOG4106TD9 Diguanylate cyclase HJW72_16140 ENOG4107RSM transcriptional regulator HJW72_16145 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HJW72_16175 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HJW72_16180 ENOG4105C4M (Ubiquinol oxidase) subunit I HJW72_16185 ENOG4105WEF catalase HJW72_16190 ENOG4108N8X transition metal ion binding HJW72_16195 ENOG4108Z9Z response to DNA damage stimulus HJW72_16210 ENOG4105E2A Dehydrogenase HJW72_16215 ENOG4105XDF Protein of unknown function (DUF1272) HJW72_16235 ENOG4108ZHR arsR family transcriptional regulator HJW72_16240 ENOG4108HMX isocitrate dehydrogenase (NADP) HJW72_16255 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HJW72_16260 ENOG41075W9 High frequency lysogenization protein HflD homolog HJW72_16265 ENOG4107QTF adenylosuccinate lyase HJW72_16285 ENOG4105IFJ Histidine kinase HJW72_16290 ENOG4105EZE Cupin 4 family protein HJW72_16310 ENOG4105D38 putrescine abc transporter HJW72_16315 ENOG4108HM4 ABC transporter HJW72_16325 ENOG4105CEY Amp-dependent synthetase and ligase HJW72_16330 ENOG4105CV1 Transketolase (EC 2.2.1.1) HJW72_16335 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HJW72_16340 ENOG4108YZG isomerase HJW72_16345 ENOG4105VI0 Pts system, glucitol sorbitol-specific HJW72_16350 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HJW72_16355 ENOG4105G63 Type III effector Hrp-dependent HJW72_16370 ENOG4105DKT Transcriptional regulator HJW72_16380 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HJW72_16385 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HJW72_16390 ENOG4105D60 lipoprotein releasing system transmembrane protein HJW72_16395 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HJW72_16400 ENOG4105D60 lipoprotein releasing system transmembrane protein HJW72_16410 ENOG4108JA2 transcriptioN-repair coupling factor HJW72_16415 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HJW72_16420 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HJW72_16430 ENOG4108IND Tetr family transcriptional regulator HJW72_16445 ENOG4107MBR 17 kDa surface antigen HJW72_16450 ENOG4105CEP NADH dehydrogenase HJW72_16455 ENOG4105D0Y UPF0227 protein HJW72_16470 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HJW72_16475 ENOG41090DQ Lipoprotein HJW72_16480 ENOG4105K59 histidine triad (HIT) protein HJW72_16485 ENOG4105CI1 PTS System HJW72_16490 ENOG4105F8V Hydrolase, tatD family HJW72_16495 ENOG4107QRG dna polymerase iii HJW72_16500 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HJW72_16505 ENOG4105HHA aminodeoxychorismate lyase HJW72_16510 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HJW72_16515 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HJW72_16520 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HJW72_16525 ENOG4105CHR reductase HJW72_16530 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HJW72_16535 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HJW72_16540 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HJW72_16545 ENOG4105VGS 50s ribosomal protein l32 HJW72_16550 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HJW72_16555 ENOG4108UHJ MAF-like protein HJW72_16560 ENOG4105EI2 Pseudouridine synthase HJW72_16570 ENOG4107QQB Ribonuclease E HJW72_16575 ENOG4105CR8 Transcriptional regulator HJW72_16580 ENOG4105EQ0 Major Facilitator superfamily HJW72_16585 ENOG4105CJR Integral membrane protein (MviN HJW72_16590 ENOG4105EP9 oxidoreductase HJW72_16600 ENOG4105D9U N-acetyltransferase HJW72_16605 ENOG4105EV4 Multidrug resistance protein mdtH HJW72_16610 ENOG4105F3T (LipO)protein HJW72_16615 ENOG4105EKE dihydroorotase HJW72_16620 ENOG4105MEA DNA damage-inducible protein i HJW72_16625 ENOG4105PVA Biofilm formation regulatory protein BssS HJW72_16635 ENOG4106974 biofilm formation HJW72_16650 ENOG4105D1S lipid A biosynthesis HJW72_16660 ENOG4108W47 Acidic protein msyB HJW72_16665 ENOG4105NAC (LipO)protein HJW72_16670 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HJW72_16680 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HJW72_16695 ENOG4108UQ5 membrane protein YcdZ HJW72_16700 ENOG4107XHZ cytoplasmic chaperone TorD family protein HJW72_16710 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HJW72_16725 ENOG4105HEI LysR family (Transcriptional regulator HJW72_16730 ENOG4105EUB pirin domain protein HJW72_16735 ENOG4105CHJ isochorismatase hydrolase HJW72_16745 ENOG4108Z33 Thiol disulfide Interchange Protein HJW72_16750 ENOG4105D5M phosphate starvation-inducible protein HJW72_16755 ENOG4105DBE peroxidase HJW72_16760 ENOG410650H (LipO)protein HJW72_16770 ENOG4105D9N nucleoside HJW72_16785 ENOG4105CK7 Sodium proline symporter HJW72_16790 ENOG4105C26 Dehydrogenase HJW72_16800 ENOG4108R86 Transcriptional regulator HJW72_16805 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HJW72_16815 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) HJW72_16820 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HJW72_16825 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HJW72_16830 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HJW72_16835 ENOG4105C2W permease HJW72_16845 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HJW72_16860 ENOG4105XH3 HJW72_16865 ENOG4105D6F Phosphatase HJW72_16875 ENOG4105CHR reductase HJW72_16890 ENOG4105CUB amino acid HJW72_16895 ENOG4105CFQ glutamine synthetase HJW72_16900 ENOG4108Z86 Glutamine amidotransferase HJW72_16905 ENOG4107VRI Transcriptional regulator HJW72_16910 ENOG4105C26 Dehydrogenase HJW72_16915 ENOG4105CJP fad dependent oxidoreductase HJW72_16920 ENOG4105EJC lysr family transcriptional regulator HJW72_16925 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HJW72_16930 ENOG4105C94 Transporter HJW72_16935 ENOG4105DVW rieske (2Fe-2S) HJW72_16940 ENOG4105C26 Dehydrogenase HJW72_16945 ENOG4105E3J oxidoreductase HJW72_16950 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HJW72_16955 ENOG4105DM4 PTS System HJW72_16960 ENOG4108YRF PTS System HJW72_16970 ENOG4108AHH pyruvate formate lyase II activase HJW72_16975 ENOG4108XCZ PTS System HJW72_16985 ENOG4106R3P AraC family transcriptional regulator HJW72_16990 ENOG4105BZU Histidine kinase HJW72_17010 ENOG4105BZU Histidine kinase HJW72_17030 ENOG4107QSI ABC, transporter HJW72_17035 ENOG4108MN8 Membrane HJW72_17045 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HJW72_17050 ENOG4108UQN AraC family transcriptional regulator HJW72_17055 ENOG4108V1U phospholipid-binding protein HJW72_17060 ENOG4105DR4 Methyltransferase HJW72_17065 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HJW72_17070 ENOG4105K4P CoA-binding domain protein HJW72_17080 ENOG41088T4 Helicase IV HJW72_17085 ENOG410901E Membrane HJW72_17090 ENOG4105EM2 membrane HJW72_17095 ENOG4108RZ1 DNA transformation protein HJW72_17100 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) HJW72_17105 ENOG4105UYK outer membrane protein a HJW72_17110 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HJW72_17115 ENOG4105DAN ATP-dependent protease HJW72_17120 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) HJW72_17125 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HJW72_17130 ENOG4108Q2G (LipO)protein HJW72_17135 ENOG4105DY2 Paraquat-inducible protein b HJW72_17140 ENOG4105F1S paraquat-inducible protein a HJW72_17145 ENOG4105C5H ABC transporter HJW72_17150 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HJW72_17155 ENOG4105QVC MOSC domain-containing protein HJW72_17160 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HJW72_17170 ENOG4108UZX fmn reductase HJW72_17175 ENOG4105GVF (ABC) transporter HJW72_17180 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HJW72_17185 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HJW72_17195 ENOG4105CD8 aminopeptidase N HJW72_17200 ENOG4107RH7 Nicotinate phosphoribosyltransferase HJW72_17205 ENOG4105CH2 amidohydrolase HJW72_17210 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HJW72_17215 ENOG4105C44 Serine transporter HJW72_17220 ENOG4107RCH Diaminopropionate ammonia-lyase HJW72_17230 ENOG4105C5S asparaginyl-tRNA synthetase HJW72_17235 ENOG4105ZIT Porin Gram-negative type HJW72_17240 ENOG4105CGF Aromatic amino acid aminotransferase HJW72_17245 ENOG4105C5X domain protein HJW72_17250 ENOG4105EAQ (twin-arginine translocation) pathway signal HJW72_17255 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HJW72_17260 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HJW72_17265 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HJW72_17270 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HJW72_17275 ENOG4106371 Methyltransferase HJW72_17280 ENOG4107S90 membrAne HJW72_17285 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HJW72_17290 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HJW72_17295 ENOG4105W49 UPF0434 protein HJW72_17300 ENOG4105T0Z Conserved Protein HJW72_17305 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HJW72_17310 ENOG4105BZ1 (ABC) transporter HJW72_17315 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HJW72_17320 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HJW72_17325 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HJW72_17330 ENOG4105CAT Cytidine monophosphate kinase HJW72_17335 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HJW72_17340 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HJW72_17345 ENOG4107VMU Membrane HJW72_17350 ENOG4105DDY UPF0142 protein ycaO HJW72_17355 ENOG4105TMB Formate nitrite transporter HJW72_17360 ENOG4105C6N Formate acetyltransferase HJW72_17365 ENOG4105F1A Pyruvate formate-lyase HJW72_17370 ENOG4108ISG Major Facilitator HJW72_17380 ENOG4107KGK dmso reductase anchor subunit HJW72_17385 ENOG4105QAX Iron-sulfur HJW72_17390 ENOG4107QY8 reductase HJW72_17395 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HJW72_17400 ENOG4105D1H recombination factor protein RarA HJW72_17405 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HJW72_17410 ENOG4105CNU cell division protein FtsK HJW72_17415 ENOG4105EW9 transcriptional regulator AsnC family HJW72_17425 ENOG4105C3M thioredoxin reductase HJW72_17430 ENOG4108JJ9 ABC, transporter HJW72_17435 ENOG4108JJ8 (ABC) transporter HJW72_17440 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HJW72_17445 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HJW72_17450 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HJW72_17455 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HJW72_17460 ENOG4105VEQ Cold shock protein HJW72_17470 ENOG4105DJY efflux transporter, rnd family, mfp subunit HJW72_17475 ENOG4105CPB ATP-dependent endonuclease of the OLD family HJW72_17485 ENOG4105DWU Membrane HJW72_17495 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HJW72_17505 ENOG4105C7K acetolactate synthase HJW72_17510 ENOG4105C5W Aldolase HJW72_17515 ENOG4105CGD Nad-dependent epimerase dehydratase HJW72_17520 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HJW72_17525 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HJW72_17535 ENOG41064MM (LipO)protein HJW72_17540 ENOG4105E5Z arginine transporter ATP-binding subunit HJW72_17545 ENOG4106PMH Extracellular solute-binding protein family 3 HJW72_17550 ENOG4105GBT ABC transporter HJW72_17555 ENOG4105DMR ABC, transporter HJW72_17560 ENOG4106TNF Periplasmic binding protein HJW72_17565 ENOG4105BZU Histidine kinase HJW72_17570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HJW72_17575 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HJW72_17580 ENOG4105RBQ inner membrane protein ybjO HJW72_17585 ENOG4105D38 putrescine abc transporter HJW72_17590 ENOG4105F38 ABC transporter, permease HJW72_17595 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HJW72_17600 ENOG4107RUE extracellular solute-binding protein family 1 HJW72_17605 ENOG4108RMJ sensory transduction regulator HJW72_17615 ENOG4108DBC nitroreductase HJW72_17620 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HJW72_17625 ENOG41090BQ Glutaredoxin HJW72_17630 ENOG4105GWF inner membrane protein YbjM HJW72_17645 ENOG4108RFG Tetr family transcriptional regulator HJW72_17650 ENOG4106UW1 Major Facilitator superfamily HJW72_17655 ENOG4108HCJ Hydrolase HJW72_17660 ENOG4107QF7 multi-drug HJW72_17665 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HJW72_17670 ENOG4107FB0 transcriptional regulator DeoR family HJW72_17675 ENOG4105DZ1 carboxypeptidase HJW72_17685 ENOG4108TGY Glutathione S-transferase HJW72_17690 ENOG4105D8V Glucose sorbosone dehydrogenase HJW72_17695 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HJW72_17700 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HJW72_17705 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HJW72_17710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJW72_17715 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJW72_17720 ENOG4105DEF Extracellular solute-binding protein, family 5 HJW72_17725 ENOG4108JQ6 ABC transporter HJW72_17730 ENOG4105D44 asparaginase HJW72_17735 ENOG4105CVM Molybdenum cofactor synthesis domain protein HJW72_17740 ENOG4105D06 uba thif-type nad fad binding protein HJW72_17745 ENOG4105F1A Pyruvate formate-lyase HJW72_17755 ENOG4108HCJ Hydrolase HJW72_17760 ENOG41072TH Protein of unknown function (DUF1479) HJW72_17765 ENOG4105ETE Transcriptional regulator (LacI family HJW72_17770 ENOG4105DPW Major facilitator superfamily MFS_1 HJW72_17780 ENOG4105C5H ABC transporter HJW72_17785 ENOG4105M2Z protein tyrosine serine phosphatase HJW72_17790 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HJW72_17795 ENOG4108TZY GntR Family Transcriptional Regulator HJW72_17800 ENOG4105CS2 ec 3.2.1.21 HJW72_17805 ENOG4105F4P )-transporter HJW72_17810 ENOG4105KST dependent repressor HJW72_17820 ENOG4108I6E Sulfatase HJW72_17825 ENOG4108T1M outer membrane protein x HJW72_17840 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HJW72_17845 ENOG4107R0W ABC transporter HJW72_17850 ENOG4105E5Q amino acid AbC transporter HJW72_17855 ENOG4105CDA abc transporter atp-binding protein HJW72_17860 ENOG4105D8X mechanosensitive ion channel HJW72_17865 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HJW72_17870 ENOG4105EW6 flavin reductase domain protein, FMN-binding HJW72_17880 ENOG4105KSC Transcriptional regulator, TraR DksA family HJW72_17885 ENOG4105VR4 UPF0379 protein ybiJ HJW72_17890 ENOG4108MTB glycosyl transferase family HJW72_17895 ENOG4105DVT helicase HJW72_17900 ENOG4105C1J atp-dependent rna helicase HJW72_17920 ENOG4105DJB Major Facilitator Superfamily HJW72_17930 ENOG4108PZW LysR family Transcriptional regulator HJW72_17935 ENOG4107MVR Transcriptional regulator HJW72_17940 ENOG4105D0S secretion protein (HlyD HJW72_17945 ENOG4105CJ1 ABC, transporter HJW72_17950 ENOG4107QWP ABC-2 type transporter HJW72_17955 ENOG4107QWP ABC-2 type transporter HJW72_17960 ENOG4105I9U inner membrane protein ybhQ HJW72_17965 ENOG4105X23 Endonuclease Exonuclease phosphatase HJW72_17970 ENOG4105DZQ phospholipase D Transphosphatidylase HJW72_17975 ENOG4107UXM Membrane HJW72_17980 ENOG4105HFZ Membrane HJW72_17985 ENOG4108ZAF Molybdopterin HJW72_17990 ENOG4105M00 molybdopterin converting factor, subunit 1 HJW72_17995 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HJW72_18000 ENOG4108RIR Molybdenum cofactor biosynthesis protein HJW72_18005 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HJW72_18010 ENOG4105CHW UPF0052 protein HJW72_18015 ENOG4105DIJ Phosphoethanolamine transferase HJW72_18020 ENOG4105XJC Two component transcriptional regulator (Winged helix family HJW72_18025 ENOG4105ECM Sensor protein basS pmrB HJW72_18030 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HJW72_18040 ENOG4108IV0 ABC, transporter HJW72_18050 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HJW72_18055 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HJW72_18060 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HJW72_18065 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HJW72_18070 ENOG4108V1U phospholipid-binding protein HJW72_18075 ENOG4105C85 amino acid HJW72_18080 ENOG4105C84 Histidine ammonia-lyase HJW72_18085 ENOG4105CGP Urocanate hydratase HJW72_18100 ENOG41088SP formiminoglutamate hydrolase HJW72_18105 ENOG4105CI2 imidazolone-5-propionate hydrolase HJW72_18110 ENOG4105NBR Pectinesterase HJW72_18120 ENOG4108U51 Universal stress protein HJW72_18125 ENOG4105ENT Efflux transporter rnd family, mfp subunit HJW72_18160 ENOG4108XDN Transcriptional regulator HJW72_18165 ENOG4105BZU Histidine kinase HJW72_18170 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HJW72_18185 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HJW72_18190 ENOG4108K4B hydrolase HJW72_18200 ENOG4105E0C molybdate abc transporter HJW72_18205 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HJW72_18215 ENOG4105F4R Transcriptional regulator mode HJW72_18225 ENOG4105DKW ABC transporter HJW72_18230 ENOG4105CMR udp-glucose 4-epimerase HJW72_18235 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HJW72_18240 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HJW72_18245 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HJW72_18250 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HJW72_18255 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HJW72_18260 ENOG4105JND homeobox protein HJW72_18265 ENOG4105PGM cation diffusion facilitator family transporter HJW72_18270 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HJW72_18275 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HJW72_18320 ENOG4105UFD tol-pal system protein YbgF HJW72_18325 ENOG4105KCK Peptidoglycan-associated lipoprotein HJW72_18335 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HJW72_18345 ENOG4105E02 MotA TolQ exbB proton channel HJW72_18350 ENOG4107YD3 Thioesterase HJW72_18355 ENOG4105KJB cyd operon protein YbgE HJW72_18365 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HJW72_18370 ENOG4105C4M (Ubiquinol oxidase) subunit I HJW72_18380 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HJW72_18385 ENOG4105CMV Succinyl-CoA synthetase subunit beta HJW72_18390 ENOG4105C7S Dehydrogenase HJW72_18395 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HJW72_18400 ENOG4105E33 succinate dehydrogenase HJW72_18405 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HJW72_18410 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HJW72_18415 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HJW72_18420 ENOG4105BZN citrate synthase HJW72_18425 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HJW72_18445 ENOG4105E7W lamb ycsf family protein HJW72_18450 ENOG4107R7A Allophanate hydrolase subunit 2 HJW72_18455 ENOG4105P4J Allophanate hydrolase, subunit 1 HJW72_18460 ENOG4107QNR UPF0135 protein HJW72_18465 ENOG4105DUX Transporter HJW72_18470 ENOG4105CVP deoxyribo-dipyrimidine photolyase HJW72_18475 ENOG4105XIQ Protein of unknown function (DUF2517) HJW72_18485 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HJW72_18490 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HJW72_18495 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HJW72_18500 ENOG4105C08 Histidine kinase HJW72_18505 ENOG4105EEX Two component transcriptional regulator (Winged helix family HJW72_18515 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HJW72_18520 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HJW72_18525 ENOG4105EV9 Alpha Beta Hydrolase HJW72_18530 ENOG4105NNH LexA regulated protein HJW72_18535 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HJW72_18540 ENOG41090R7 Ferric uptake HJW72_18545 ENOG4105CSH Transporter HJW72_18550 ENOG4105GX6 (LipO)protein HJW72_18555 ENOG4105J5J Outer membrane porin HJW72_18565 ENOG4105CX6 glutaminyL-tRNA synthetase HJW72_18570 ENOG4105CI1 PTS System HJW72_18575 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HJW72_18580 ENOG4105CE4 GlcNAc 6-P deacetylase HJW72_18585 ENOG4105E2R ROK family HJW72_18590 ENOG4105D4U had-superfamily hydrolase, subfamily iia HJW72_18595 ENOG4105CAQ asparagine synthetase HJW72_18635 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HJW72_18640 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HJW72_18645 ENOG4105C9A Phoh family HJW72_18650 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HJW72_18655 ENOG4108JU5 Magnesium and cobalt efflux protein HJW72_18660 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HJW72_18665 ENOG4107RP9 extracellular solute-binding protein, family 3 HJW72_18670 ENOG4105EAD ABC transporter HJW72_18675 ENOG4105DRP amino acid AbC transporter HJW72_18680 ENOG4105CDA abc transporter atp-binding protein HJW72_18695 ENOG4107PAI alpha helical protein HJW72_18700 ENOG4105C8T Leucyl-tRNA synthetase HJW72_18710 ENOG4105DJF DNA polymerase III, delta' subunit HJW72_18715 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HJW72_18720 ENOG4108TGR phosphatase HJW72_18725 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HJW72_18730 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HJW72_18735 ENOG4105CJN penicillin-binding protein HJW72_18740 ENOG4105CNI cell division protein FtsW HJW72_18745 ENOG4105K6T rare lipoprotein A HJW72_18750 ENOG4105DZ1 carboxypeptidase HJW72_18755 ENOG4108Z43 UPF0250 protein HJW72_18760 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HJW72_18765 ENOG41064T2 transcriptional regulator, lysR family HJW72_18770 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HJW72_18775 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HJW72_18795 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HJW72_18800 ENOG4105CEE C4-dicarboxylate transporter HJW72_18805 ENOG4105KTS ribonuclease HJW72_18810 ENOG4105NXH GreA GreB family elongation factor HJW72_18815 ENOG4108U51 Universal stress protein HJW72_18820 ENOG4108JU3 Alkyl hydroperoxide reductase HJW72_18825 ENOG4105D3R alkyl hydroperoxide reductase HJW72_18830 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HJW72_18835 ENOG4105DQS Transcriptional regulator HJW72_18840 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HJW72_18845 ENOG4105GTN ParB Domain Protein Nuclease HJW72_18850 ENOG4105CHM Aminotransferase HJW72_18855 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HJW72_18860 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HJW72_18875 ENOG4105C2J ABC transporter HJW72_18885 ENOG4105CNN ABC, transporter HJW72_18895 ENOG4108M3J Dehydrogenase HJW72_18905 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HJW72_18910 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HJW72_18920 ENOG4105DZC cytosine deaminase HJW72_18930 ENOG4105ECY inositol monophosphatase HJW72_18935 ENOG4105CXY transporter HJW72_18940 ENOG4105D6F Phosphatase HJW72_18945 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HJW72_18950 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HJW72_18965 ENOG4105CNN ABC, transporter HJW72_18970 ENOG4105C2J ABC transporter HJW72_18975 ENOG4107SCQ Iron-containing alcohol dehydrogenase HJW72_18980 ENOG4105CHR reductase HJW72_18995 ENOG4105VCD cytoplasmic protein HJW72_19000 ENOG4105D22 carbon starvation protein HJW72_19005 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HJW72_19010 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HJW72_19015 ENOG4105WQI isochorismatase HJW72_19020 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HJW72_19025 ENOG4105E4F Isochorismate synthase HJW72_19030 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HJW72_19035 ENOG4105E8G Major facilitator Superfamily HJW72_19040 ENOG4105DQ5 transport system permease protein HJW72_19045 ENOG4105TVJ transport system, permease HJW72_19050 ENOG4105E0A ABC, transporter HJW72_19055 ENOG4105C0W non-ribosomal peptide synthetase HJW72_19060 ENOG41085A6 mbth domain-containing protein HJW72_19065 ENOG4105E93 esterase HJW72_19070 ENOG4107RNH Outer membrane receptor FepA HJW72_19075 ENOG4108TSE Transferase HJW72_19080 ENOG4108IUS Transketolase HJW72_19085 ENOG4108HHA Transketolase HJW72_19090 ENOG4105DKT Transcriptional regulator HJW72_19095 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HJW72_19100 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HJW72_19120 ENOG4105C2J ABC transporter HJW72_19125 ENOG4105CNN ABC, transporter HJW72_19145 ENOG4108R85 Short chain dehydrogenase HJW72_19160 ENOG410810E transcriptional regulator, lysR family HJW72_19165 ENOG4105CUY Mechanosensitive ion channel HJW72_19170 ENOG4108WN0 inhibitor of vertebrate lysozyme HJW72_19175 ENOG4105C94 Transporter HJW72_19190 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HJW72_19200 ENOG4105DEF Extracellular solute-binding protein, family 5 HJW72_19205 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HJW72_19210 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HJW72_19215 ENOG4105C3U ABC transporter HJW72_19220 ENOG4108JQ7 (ABC) transporter HJW72_19225 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HJW72_19230 ENOG4105EMU Dehydrogenase HJW72_19240 ENOG4105GBT ABC transporter HJW72_19250 ENOG4105E5Q amino acid AbC transporter HJW72_19255 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HJW72_19265 ENOG4105CHM Aminotransferase HJW72_19270 ENOG4105T38 integral membrane protein HJW72_19275 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HJW72_19280 ENOG4108T58 Mg2 transport protein CorA HJW72_19305 ENOG4105WQ6 Membrane HJW72_19310 ENOG4105HFT AraC family transcriptional regulator HJW72_19320 ENOG410630P Transcriptional regulator HJW72_19325 ENOG4105MSB protein, conserved in bacteria HJW72_19330 ENOG4108RCM Nitroreductase HJW72_19360 ENOG4105CUY Mechanosensitive ion channel HJW72_19365 ENOG4105ETE Transcriptional regulator (LacI family HJW72_19375 ENOG4105CK5 oxidoreductase HJW72_19385 ENOG4105EAA nucleoside HJW72_19390 ENOG4105C85 amino acid HJW72_19400 ENOG4108NS2 receptor HJW72_19405 ENOG4105C26 Dehydrogenase HJW72_19410 ENOG4105CJP fad dependent oxidoreductase HJW72_19420 ENOG4105CUB amino acid HJW72_19435 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase HJW72_19440 ENOG4105DGU Histone deacetylase HJW72_19450 ENOG4108UAJ Transcriptional regulator HJW72_19460 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HJW72_19475 ENOG4105CPC Aldo Keto reductase HJW72_19480 ENOG4105E89 ABC transporter HJW72_19485 ENOG4105CH2 amidohydrolase HJW72_19520 ENOG4105EHG Permease protein HJW72_19525 ENOG4105E0A ABC, transporter HJW72_19530 ENOG4105EFX secretion protein, HlyD family HJW72_19535 ENOG4105KK7 inner membrane protein YiaW HJW72_19550 ENOG4105D7K pfkb domain protein HJW72_19555 ENOG4108M0B Sucrose porin HJW72_19560 ENOG4105C5Y PTS System HJW72_19565 ENOG4108HKT sucrose-6-phosphate hydrolase HJW72_19570 ENOG4105WBN Transcriptional regulator (LacI family HJW72_19585 ENOG4108HWV )-transporter HJW72_19590 ENOG4105C2J ABC transporter HJW72_19615 ENOG4107TYG Oxidoreductase domain-containing protein HJW72_19630 ENOG4105CRK lysyL-tRNA synthetase HJW72_19635 ENOG4105DUX Transporter HJW72_19640 ENOG4105CXN decarboxylase HJW72_19645 ENOG4105D5Q Arginine ornithine antiporter HJW72_19650 ENOG4108M3R transcriptional activator CadC HJW72_19660 ENOG4105D1S lipid A biosynthesis HJW72_19670 ENOG4105BZN citrate synthase HJW72_19705 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HJW72_19710 ENOG4105WQ3 Rna-binding protein HJW72_19715 ENOG4105C8N cysteinyl-tRNA synthetase HJW72_19720 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HJW72_19725 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HJW72_19735 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HJW72_19740 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HJW72_19760 ENOG4105CV6 ABC transporter, permease HJW72_19765 ENOG4108I0Y (ABC) transporter HJW72_19770 ENOG4108UJV acyl-CoA thioesterase i HJW72_19775 ENOG4105E1F short-chain dehydrogenase reductase HJW72_19780 ENOG4107QR8 Thioredoxin HJW72_19785 ENOG4105C4B ABC transporter, permease HJW72_19790 ENOG41083J0 (ABC) transporter HJW72_19795 ENOG4107QX8 SPFH domain, Band 7 family protein HJW72_19800 ENOG4105G5H Membrane HJW72_19805 ENOG4108Z6Z Transcriptional regulator HJW72_19810 ENOG4105C59 p-type ATPase HJW72_19815 ENOG4105MBR gumn family HJW72_19820 ENOG4108Z66 YbaK ebsC protein HJW72_19825 ENOG4105CGH 5'-nucleotidase HJW72_19830 ENOG4105EU0 Major facilitator Superfamily HJW72_19845 ENOG4105CKD glutathione-regulated potassium-efflux system protein HJW72_19850 ENOG4107RE1 Inosine-guanosine kinase HJW72_19860 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HJW72_19865 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HJW72_19870 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HJW72_19875 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HJW72_19880 ENOG4107QMP dna polymerase iii subunits gamma and tau HJW72_19885 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HJW72_19890 ENOG4105WD1 Membrane HJW72_19895 ENOG4108URS primosomal replication protein n'' HJW72_19900 ENOG4106428 Protein of unknown function (DUF2496) HJW72_19910 ENOG4105EGS Mechanosensitive ion channel HJW72_19915 ENOG4107XI7 Tetr family transcriptional regulator HJW72_19920 ENOG4105C1P efflux transporter, rnd family, mfp subunit HJW72_19925 ENOG4105BZS acriflavin resistance protein HJW72_19930 ENOG4108UKR Biofilm formation regulator YbaJ HJW72_19940 ENOG4108UW5 maltose o-acetyltransferase HJW72_19950 ENOG4105GSJ Inner membrane protein ylaC HJW72_19965 ENOG4105YK5 50S ribosomal protein L36 HJW72_19975 ENOG4105ETE Transcriptional regulator (LacI family HJW72_19980 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJW72_19985 ENOG4105CI1 PTS System HJW72_19990 ENOG4105C4C beta-galactosidase HJW72_20000 ENOG4105EG2 ABC transporter, permease HJW72_20010 ENOG4107FKK extracellular solute-binding protein family 1 HJW72_20030 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter HJW72_20035 ENOG41061MD high-affinity nickel-transporter HJW72_20040 ENOG4108VW9 Membrane HJW72_20070 ENOG41080UX Methyltransferase HJW72_20075 ENOG4108MNP Glycoprotein polysaccharide metabolism HJW72_20080 ENOG4105C29 acyl-CoA thioesterase HJW72_20085 ENOG4105BZU Histidine kinase HJW72_20090 ENOG4108YZA Nitrogen regulatory protein pii HJW72_20095 ENOG4105BZ1 (ABC) transporter HJW72_20100 ENOG4105BZ1 (ABC) transporter HJW72_20105 ENOG4108XM1 transcriptional regulator AsnC family HJW72_20115 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HJW72_20120 ENOG4108NFA extracellular solute-binding protein HJW72_20125 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HJW72_20130 ENOG4108TGP Thioesterase superfamily protein HJW72_20135 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HJW72_20140 ENOG4105EIN peptidylprolyl cis-trans isomerase HJW72_20145 ENOG4105K70 DNA-binding protein HJW72_20150 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HJW72_20155 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HJW72_20165 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HJW72_20175 ENOG4105M85 Bola protein HJW72_20180 ENOG4105IEY (LipO)protein HJW72_20185 ENOG4105EYM Major Facilitator superfamily HJW72_20190 ENOG4105E2S oxidase) subunit II HJW72_20195 ENOG4105BZ9 Cytochrome C oxidase, subunit I HJW72_20200 ENOG4105CCU oxidase (Subunit III) HJW72_20205 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HJW72_20210 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HJW72_20220 ENOG4107HP6 Transcriptional regulator HJW72_20225 ENOG4105E2X shikimate dehydrogenase HJW72_20230 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HJW72_20240 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HJW72_20250 ENOG4105D2S major facilitator superfamily HJW72_20255 ENOG4105CIB oxidoreductase Domain protein HJW72_20260 ENOG4107RDB Major Facilitator HJW72_20270 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HJW72_20275 ENOG4107S0N DJ-1 family HJW72_20285 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HJW72_20290 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HJW72_20295 ENOG4105CTB Polyprenyl synthetase HJW72_20300 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HJW72_20305 ENOG4105CPC Aldo Keto reductase HJW72_20310 ENOG4108ZAI phosphatidylglycerophosphatase a HJW72_20315 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HJW72_20320 ENOG4107YIM Involved in the transcription termination process (By similarity) HJW72_20325 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HJW72_20330 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HJW72_20335 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HJW72_20340 ENOG4108KIC (LipO)protein HJW72_20345 ENOG4105DRB nucleoside-specific channel-forming protein HJW72_20360 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HJW72_20365 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HJW72_20370 ENOG4105VIE preprotein translocase, subunit YajC HJW72_20375 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HJW72_20380 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HJW72_20390 ENOG4108ZYK Acyl carrier protein phosphodiesterase HJW72_20395 ENOG4105D3R alkyl hydroperoxide reductase HJW72_20405 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HJW72_20420 ENOG4108MGF sugar kinase HJW72_20430 ENOG4105CI2 imidazolone-5-propionate hydrolase HJW72_20440 ENOG4105CHJ isochorismatase hydrolase HJW72_20445 ENOG4105EQ1 Transcriptional regulator HJW72_20450 ENOG4107R28 alpha amylase, catalytic region HJW72_20455 ENOG4105C85 amino acid HJW72_20460 ENOG4105CWM branched-chain amino acid transport system II carrier protein HJW72_20465 ENOG4105BZU Histidine kinase HJW72_20470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HJW72_20475 ENOG4107RH8 nuclease SbcCD subunit D HJW72_20480 ENOG4105EYH Exonuclease HJW72_20485 ENOG4105DKQ ROK family HJW72_20490 ENOG4105DH7 May be involved in recombination (By similarity) HJW72_20495 ENOG4105NBK UPF0345 protein HJW72_20500 ENOG4105HBA AroM protein HJW72_20505 ENOG4105SS3 HJW72_20510 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HJW72_20515 ENOG4105G4C Periplasmic ligand-binding sensor protein HJW72_20520 ENOG4108UPT UPF0178 protein HJW72_20525 ENOG4105II7 pyrroline-5-carboxylate reductase HJW72_20530 ENOG4105VIF phosphate starvation-inducible protein HJW72_20535 ENOG4105G6Z alkaline phosphatase HJW72_20555 ENOG4105CPF Cell wall formation (By similarity) HJW72_20560 ENOG4105UNH Membrane HJW72_20565 ENOG4105FR5 inner membrane protein YaiY HJW72_20570 ENOG4107QS8 (LipO)protein HJW72_20575 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HJW72_20580 ENOG4108RWI nicotinamidase HJW72_20585 ENOG4107R6D beta-lactam binding protein AmpH HJW72_20590 ENOG4105D52 delta-aminolevulinic acid dehydratase HJW72_20595 ENOG4108UK5 Transposase HJW72_20605 ENOG4105E2B Taurine dioxygenase HJW72_20610 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HJW72_20615 ENOG4108ETV ABC transporter HJW72_20620 ENOG4106FTQ Taurine ABC transporter, periplasmic HJW72_20625 ENOG4107QK5 Homocysteine s-methyltransferase HJW72_20630 ENOG4108IQI permease HJW72_20640 ENOG4105C85 amino acid HJW72_20645 ENOG4105CPD ethanolamine ammonia-lyase HJW72_20650 ENOG4107FQ9 ethanolamine ammonia-lyase HJW72_20665 ENOG4105C32 Amino acid ABC transporter (Permease) HJW72_20670 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HJW72_20675 ENOG4105C0Z ABC transporter HJW72_20680 ENOG4108IV0 ABC, transporter HJW72_20690 ENOG4105CT1 (ABC) transporter HJW72_20695 ENOG4105CDA abc transporter atp-binding protein HJW72_20700 ENOG4105EZ7 amino acid ABC transporter HJW72_20705 ENOG4105DRP amino acid AbC transporter HJW72_20715 ENOG4106PYX Receptor HJW72_20720 ENOG4108N3D putative enzyme HJW72_20725 ENOG4108NN8 Fimbrial protein HJW72_20730 ENOG4108GWT fimbrillin MatB HJW72_20735 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon HJW72_20745 ENOG4105EHI Phosphonate ABC transporter, periplasmic HJW72_20755 ENOG4105S7S phosphonate abc transporter HJW72_20770 ENOG4108QBX (LipO)protein HJW72_20775 ENOG4105FCK Membrane HJW72_20780 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HJW72_20880 ENOG4105T95 Thiol disulfide interChange protein HJW72_20935 ENOG41067CV Integrase HJW72_20980 ENOG41061ZR Transcriptional regulator HJW72_20985 ENOG4107R0V Pyruvate dehydrogenase HJW72_20990 ENOG4105CPP Dehydrogenase, E1 component HJW72_21000 ENOG4107QN2 dihydrolipoyl dehydrogenase HJW72_21010 ENOG41061GT Aldolase HJW72_21020 ENOG4105CMG Carbohydrate kinase HJW72_21025 ENOG4105CHR reductase HJW72_21030 ENOG4108JQ1 Dehydrogenase HJW72_21035 ENOG4105DT3 PTS system, galactitol-specific IIc component HJW72_21040 ENOG4108TGY Glutathione S-transferase HJW72_21045 ENOG4105DTA methyltransferase HJW72_21050 ENOG4105YCT UPF0386 protein HJW72_21060 ENOG4105D5U fad dependent oxidoreductase HJW72_21065 ENOG4105C26 Dehydrogenase HJW72_21070 ENOG4108JPW Aminotransferase HJW72_21075 ENOG4105C85 amino acid HJW72_21080 ENOG4108PVQ transcriptional regulator HJW72_21085 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HJW72_21090 ENOG4105V1F Fermentation respiration switch protein HJW72_21095 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HJW72_21100 ENOG4105CIN aminoacyl-histidine dipeptidase HJW72_21105 ENOG4108HYG acetyltransferase HJW72_21110 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HJW72_21125 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HJW72_21130 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJW72_21135 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJW72_21140 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJW72_21145 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJW72_21150 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HJW72_21155 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HJW72_21160 ENOG4105E7A Glutamine amidotransferase HJW72_21165 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HJW72_21170 ENOG4107QPN acyl-Coa dehydrogenase HJW72_21175 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HJW72_21180 ENOG4108VP3 Lysine exporter protein (LysE YggA) HJW72_21185 ENOG41090KR LysR family transcriptional Regulator HJW72_21195 ENOG4107RZZ dna polymerase iii epsilon subunit HJW72_21200 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HJW72_21205 ENOG4105D1A Methyltransferase HJW72_21210 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HJW72_21215 ENOG4105E9H Lytic Murein transglycosylase HJW72_21220 ENOG4105F2W methyltransferase HJW72_21230 ENOG4105F27 Major Facilitator HJW72_21235 ENOG4105HEI LysR family (Transcriptional regulator HJW72_21240 ENOG4105CV8 reductase HJW72_21275 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HJW72_21280 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HJW72_21285 ENOG4108UMI ABC transporter, permease HJW72_21290 ENOG4105D01 (LipO)protein HJW72_21295 ENOG4108R8X outer membrane lipoprotein HJW72_21300 ENOG4108R96 Methyltransferase, YaeB family HJW72_21305 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HJW72_21310 ENOG4108UY0 (LipO)protein HJW72_21315 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HJW72_21320 ENOG4108YZN class I peptide chain release factor HJW72_21325 ENOG4108VWS Yaeq family HJW72_21330 ENOG4105W1I UPF0253 protein HJW72_21335 ENOG4105M1T rho-binding antiterminator HJW72_21340 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HJW72_21345 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HJW72_21350 ENOG4105CXN decarboxylase HJW72_21355 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HJW72_21360 ENOG4105C0B DNA polymerase III (alpha subunit) HJW72_21365 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HJW72_21370 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HJW72_21375 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HJW72_21380 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HJW72_21385 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HJW72_21390 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HJW72_21395 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HJW72_21400 ENOG4105DZP Membrane-associated zinc metalloprotease HJW72_21405 ENOG4105KNE Phosphatidate cytidylyltransferase HJW72_21415 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HJW72_21425 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HJW72_21430 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HJW72_21435 ENOG4105CE9 30S ribosomal protein S2 HJW72_21440 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HJW72_21445 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HJW72_21450 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HJW72_21455 ENOG4108T8E UPF0325 protein HJW72_21460 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HJW72_21465 ENOG4105C0H protease HJW72_21470 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HJW72_21475 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HJW72_21480 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HJW72_21485 ENOG4105EN6 Membrane HJW72_21490 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HJW72_21495 ENOG4105CMQ Chloride channel HJW72_21500 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HJW72_21505 ENOG4105S6R Iron-hydroxamate transporter permease subunit HJW72_21510 ENOG4105J76 Periplasmic binding protein HJW72_21515 ENOG4105E0A ABC, transporter HJW72_21520 ENOG4105E0K tonB-dependent siderophore receptor HJW72_21525 ENOG4105BZ4 penicillin-binding protein HJW72_21615 ENOG4105CQ7 ATP-dependent helicase HJW72_21620 ENOG4107XID 2'-5' rna ligase HJW72_21625 ENOG4105PW4 Sugar fermentation stimulation protein homolog HJW72_21630 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HJW72_21635 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HJW72_21640 ENOG4105DJ0 Poly(A) Polymerase HJW72_21645 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HJW72_21650 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HJW72_21655 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HJW72_21660 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HJW72_21665 ENOG4107BJW polysaccharide deacetylase HJW72_21670 ENOG4108YTN IIa component HJW72_21675 ENOG4105E3A (ABC) transporter HJW72_21680 ENOG4105DA5 (ABC) transporter HJW72_21685 ENOG41077A9 carbonic anhydrase HJW72_21690 ENOG4108UGV hypoxanthine phosphoribosyltransferase HJW72_21700 ENOG4105DZG Dehydrogenase HJW72_21705 ENOG4105E3B Multicopper oxidase HJW72_21710 ENOG4108ZRK uncharacterized protein yacC HJW72_21730 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HJW72_21735 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HJW72_21740 ENOG4108ZIG UPF0231 protein HJW72_21745 ENOG4107QIJ Aconitate hydratase 2 HJW72_21755 ENOG4108NST exported protein HJW72_21770 ENOG4107QN2 dihydrolipoyl dehydrogenase HJW72_21775 ENOG4107QSN dihydrolipoamide acetyltransferase HJW72_21780 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HJW72_21785 ENOG41073TP transcriptional regulator HJW72_21790 ENOG4105C85 amino acid HJW72_21795 ENOG4105CT4 transporter HJW72_21800 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HJW72_21805 ENOG4106A72 regulatory protein AmpE HJW72_21810 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HJW72_21815 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HJW72_21820 ENOG4108ZUW Major pilin subunit HJW72_21825 ENOG4107QHF type ii secretion system protein e HJW72_21830 ENOG4105D7Q type ii secretion system HJW72_21835 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HJW72_21840 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HJW72_21845 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HJW72_21850 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HJW72_21855 ENOG4105M6F mutator MutT protein HJW72_21860 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HJW72_21865 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HJW72_21870 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HJW72_21875 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HJW72_21880 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HJW72_21885 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HJW72_21895 ENOG4105DFU Cell wall formation (By similarity) HJW72_21900 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HJW72_21905 ENOG4105CNI cell division protein FtsW HJW72_21915 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HJW72_21920 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HJW72_21925 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HJW72_21930 ENOG4105CJN penicillin-binding protein HJW72_21935 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HJW72_21940 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HJW72_21950 ENOG4107B7Y DNA-binding transcriptional regulator FruR HJW72_21955 ENOG4108ZP8 Acetolactate synthase small subunit HJW72_21960 ENOG4105C7K acetolactate synthase HJW72_21965 ENOG41064T2 transcriptional regulator, lysR family HJW72_21980 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HJW72_21990 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HJW72_21995 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HJW72_22010 ENOG4105EMV Major Facilitator HJW72_22015 ENOG4105FF2 Type I DHQase HJW72_22020 ENOG4105C5Q Transcriptional regulator HJW72_22030 ENOG4105S8Q sugar efflux transporter HJW72_22055 ENOG4106SMU thiamine transporter membrane protein HJW72_22065 ENOG4108KF1 Membrane HJW72_22070 ENOG41063TF transcriptional regulator (AraC HJW72_22080 ENOG4105EF1 ribulokinase HJW72_22085 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HJW72_22090 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HJW72_22095 ENOG4105CQ2 DNA polymerase HJW72_22100 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HJW72_22105 ENOG4105D3G Pseudouridine synthase HJW72_22115 ENOG4105D2K citrate carrier protein HJW72_22120 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HJW72_22125 ENOG4106YYS transcriptional regulatory protein HJW72_22130 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HJW72_22135 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HJW72_22145 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HJW72_22150 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HJW72_22160 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HJW72_22165 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HJW72_22170 ENOG4105CKD glutathione-regulated potassium-efflux system protein HJW72_22180 ENOG4105M5B (LipO)protein HJW72_22185 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HJW72_22190 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HJW72_22200 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HJW72_22205 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HJW72_22210 ENOG4105EXG Transcriptional regulator HJW72_22220 ENOG4105DU0 nucleoside hydrolase HJW72_22225 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HJW72_22230 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HJW72_22235 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HJW72_22245 ENOG4105DTN riboflavin biosynthesis protein ribF HJW72_22265 ENOG41063Z6 transcriptional regulator, lysR family HJW72_22270 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HJW72_22275 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HJW72_22280 ENOG4105CFG Acts as a chaperone (By similarity) HJW72_22285 ENOG4108WTA UPF0412 protein YaaI HJW72_22290 ENOG4108QUJ UPF0174 protein YaaW HJW72_22295 ENOG4106HK8 GPR1 FUN34 yaaH family protein HJW72_22300 ENOG4105CSH Transporter HJW72_22305 ENOG4108RIR Molybdenum cofactor biosynthesis protein HJW72_22310 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HJW72_22315 ENOG4105BZG amino acid carrier protein HJW72_22320 ENOG4105D1Q UPF0246 protein HJW72_22330 ENOG4105D98 threonine synthase HJW72_22335 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HJW72_22340 ENOG4105CFH Aspartokinase HJW72_22355 ENOG4106FVC RNA methyltransferase HJW72_22360 ENOG410759A HJW72_22365 ENOG41065U4 response regulator HJW72_22370 ENOG4105CT7 inner membrane cred family protein HJW72_22375 ENOG4105EB3 Histidine kinase HJW72_22380 ENOG4105E3W Two component transcriptional regulator (Winged helix family HJW72_22385 ENOG4108RH0 Crea protein HJW72_22390 ENOG4105UEI Transcriptional Regulator AraC Family HJW72_22395 ENOG4105CVJ phosphoglycerate mutase HJW72_22400 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HJW72_22405 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HJW72_22410 ENOG4107SC1 transglycosylase HJW72_22415 ENOG4105C5H ABC transporter HJW72_22420 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HJW72_22425 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HJW72_22430 ENOG4105EAC phosphoserine phosphatase HJW72_22435 ENOG41062Z9 Membrane HJW72_22440 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) HJW72_22455 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HJW72_22465 ENOG4105D9N nucleoside HJW72_22470 ENOG4105EYA deoxyribonuclease HJW72_22475 ENOG4108NRW Phospholipase, patatin family HJW72_22480 ENOG41075IC Protein of unknown function (DUF1328) HJW72_22485 ENOG4105K3G Periplasmic Protein HJW72_22490 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HJW72_22495 ENOG4105PAD Hydrolase HJW72_22500 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HJW72_22505 ENOG4108WPU DNA polymerase III subunit psi HJW72_22510 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HJW72_22530 ENOG4105YBH Protein of unknown function (DUF1435) HJW72_22540 ENOG4106TD9 Diguanylate cyclase HJW72_22545 ENOG4108819 ferric iron reductase HJW72_22550 ENOG4105CK1 PTS System HJW72_22555 ENOG4108UIN ybak prolyl-trna synthetase associated region HJW72_22560 ENOG4108T94 DNA-binding transcriptional activator BglJ HJW72_22565 ENOG4108N8T regulatoR HJW72_22575 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HJW72_22580 ENOG4105DWK Membrane HJW72_22585 ENOG4107XM3 UPF0442 protein HJW72_22590 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HJW72_22595 ENOG4106CVF DNA replication protein HJW72_22600 ENOG4105RI1 glycoprotein receptor HJW72_22610 ENOG4105DNE Transposase HJW72_22625 ENOG4105F3R pts system mannose fructose sorbose family iid HJW72_22630 ENOG4105ETZ PTS System HJW72_22635 ENOG4105KPI PTS system sorbose subfamily IIB component HJW72_22645 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HJW72_22655 ENOG4105XYF acetyltransferase HJW72_22660 ENOG4106KNT transcriptional regulator HJW72_22665 ENOG4108RTU Aldolase HJW72_22670 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HJW72_22700 ENOG4105DG4 malate L-lactate dehydrogenase HJW72_22715 ENOG4108V8F Transcriptional regulator, MarR family HJW72_22725 ENOG4105ERH Fumarylacetoacetate hydrolase HJW72_22735 ENOG4105C26 Dehydrogenase HJW72_22740 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HJW72_22755 ENOG4105CNV Aldolase HJW72_22765 ENOG4108NKV transcriptional regulator HJW72_22770 ENOG4105EFA 4-hydroxyphenylacetate HJW72_22775 ENOG4107UWN reductase HJW72_22780 ENOG4105CKT filamentous hemagglutinin HJW72_22790 ENOG4105CKT filamentous hemagglutinin HJW72_22795 ENOG4105CKT filamentous hemagglutinin HJW72_22810 ENOG4105CKT filamentous hemagglutinin HJW72_22815 ENOG4105D5K Hemolysin activator protein HJW72_22820 ENOG4105D22 carbon starvation protein HJW72_22825 ENOG4105VCD cytoplasmic protein HJW72_22830 ENOG4105CKI cobalamin synthesis protein HJW72_22840 ENOG4105C26 Dehydrogenase HJW72_22845 ENOG4105DNE Transposase HJW72_22850 ENOG4106AXJ AraC family transcriptional regulator HJW72_22860 ENOG4106BRA Membrane HJW72_22865 ENOG41083G8 Multidrug resistance protein MdtM HJW72_22875 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HJW72_22880 ENOG4105CIZ coA-substrate-specific enzyme activase HJW72_22895 ENOG4105EFX secretion protein, HlyD family HJW72_22905 ENOG4106DIZ Domain of unknown function (DUF1127) HJW72_22910 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HJW72_22920 ENOG41064T2 transcriptional regulator, lysR family HJW72_22925 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HJW72_22930 ENOG4105CNN ABC, transporter HJW72_22935 ENOG4105CNN ABC, transporter HJW72_22940 ENOG4105C2J ABC transporter HJW72_22945 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HJW72_22955 ENOG4105BZU Histidine kinase HJW72_22960 ENOG4105D0S secretion protein (HlyD HJW72_22965 ENOG4105CJ1 ABC, transporter HJW72_22970 ENOG4105CMI transporter HJW72_23000 ENOG4105EZE Cupin 4 family protein HJW72_23015 ENOG4105GR3 Histidine kinase HJW72_23020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HJW72_23025 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HJW72_23030 ENOG410624V efflux system protein HJW72_23035 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HJW72_23040 ENOG4108IJF Heavy metal efflux pump, CzcA HJW72_23050 ENOG4105QNF Outer membrane lipoprotein HJW72_23055 ENOG4108XDN Transcriptional regulator HJW72_23065 ENOG4107FW0 short-chain dehydrogenase reductase HJW72_23080 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HJW72_23100 ENOG4107SEY Conserved Protein HJW72_23105 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJW72_23115 ENOG4105C93 Xylose Isomerase HJW72_23120 ENOG4105CT4 transporter HJW72_23125 ENOG4105DSG hydrolase family 43 HJW72_23145 ENOG4107S6X Glycosyl transferase, family 2 HJW72_23225 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HJW72_23235 ENOG4108YGG dna repair protein HJW72_23240 ENOG4105MFG Antirestriction protein HJW72_23245 ENOG4106H6R UPF0380 protein HJW72_23260 ENOG4108PZQ Inner membrane protein YeeR HJW72_23265 ENOG4105F4K antigen 43 HJW72_23380 ENOG41077A9 carbonic anhydrase HJW72_23385 ENOG4105CHH sulfate transporter HJW72_23390 ENOG4105DQ4 alcohol dehydrogenase HJW72_23400 ENOG4105DRS transport system, permease HJW72_23405 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HJW72_23410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HJW72_23420 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HJW72_23425 ENOG4105F0H myo-inositol catabolism protein HJW72_23435 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HJW72_23445 ENOG4105D7K pfkb domain protein HJW72_23450 ENOG4105CHC glucokinase (EC 2.7.1.2) HJW72_23455 ENOG4105DH8 myo-inositol catabolism HJW72_23460 ENOG4105C26 Dehydrogenase HJW72_23470 ENOG4105D7A ATP-binding protein HJW72_23475 ENOG4108K5H permease YjgP YjgQ family protein HJW72_23480 ENOG4108M8S permease YjgP YjgQ family protein HJW72_23485 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HJW72_23490 ENOG4105MYG DNA polymerase iii, chi subunit HJW72_23495 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HJW72_23500 ENOG4108MJ3 acetyltransferase HJW72_23505 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HJW72_23510 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HJW72_23520 ENOG4105XEP YhcH YjgK YiaL family protein HJW72_23530 ENOG4105CXT aspartate transcarbamylase HJW72_23535 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HJW72_23540 ENOG4105KME endoribonuclease L-psp HJW72_23550 ENOG4105D4X repressor HJW72_23555 ENOG4105C5Y PTS System HJW72_23560 ENOG4105CG3 alpha amylase, catalytic region HJW72_23565 ENOG4105CK1 PTS System HJW72_23570 ENOG4105F8D glycoside hydrolase family 4 HJW72_23590 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HJW72_23595 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HJW72_23600 ENOG4105K4U addiction module toxin, RelE StbE family HJW72_23610 ENOG4105EMD TRANSCRIPTIONal HJW72_23615 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HJW72_23630 ENOG41069H0 dihydroorotase EC 3.5.2.3 HJW72_23660 ENOG4108XVM Cytochrome b(562) HJW72_23665 ENOG4105CMS peptidase U62, modulator of DNA gyrase HJW72_23670 ENOG4105N42 UPF0307 protein HJW72_23690 ENOG4105DFU Cell wall formation (By similarity) HJW72_23695 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HJW72_23700 ENOG41062B0 ABC transporter, permease HJW72_23705 ENOG4107R9N ABC transporter HJW72_23710 ENOG4105C2J ABC transporter HJW72_23715 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HJW72_23720 ENOG4105F0N pyrophosphate phospho-hydrolase HJW72_23730 ENOG4108ZHD aig2 family HJW72_23735 ENOG4105MA0 exported protein HJW72_23740 ENOG4105CFU surface antigen HJW72_23750 ENOG4105C37 (CBS) domain HJW72_23760 ENOG4105C4C beta-galactosidase HJW72_23770 ENOG41061GZ Protein of unknown function (DUF1107) HJW72_23775 ENOG4108UUE Transcriptional regulator HJW72_23780 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HJW72_23785 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HJW72_23790 ENOG4105KVH Transcriptional regulator HJW72_23795 ENOG4105ECR NmrA family HJW72_23805 ENOG4105DXC membrane HJW72_23810 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HJW72_23820 ENOG4108V1T peptidylprolyl cis-trans isomerase HJW72_23825 ENOG4105FHY Opacity-associated protein A HJW72_23830 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HJW72_23835 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HJW72_23840 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HJW72_23845 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HJW72_23850 ENOG4105KIT UPF0379 protein yjfY HJW72_23875 ENOG4106ETB IIa component HJW72_23885 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HJW72_23900 ENOG4108MXZ Esterase HJW72_23905 ENOG4105WSB biofilm stress and motility protein A HJW72_23910 ENOG4105S17 UPF0379 protein yjfN HJW72_23915 ENOG4105CSU acyl-Coa dehydrogenase HJW72_23920 ENOG4105C2N RNA methyltransferase TrmH family group 3 HJW72_23925 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HJW72_23930 ENOG4105KPV Transcriptional regulator HJW72_23935 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HJW72_23950 ENOG4105EPW hflc protein HJW72_23955 ENOG4107QJR hflk protein HJW72_23960 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HJW72_23970 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HJW72_23975 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HJW72_23985 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HJW72_23990 ENOG4105K8N protein family UPF0079, ATPase HJW72_23995 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HJW72_24000 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HJW72_24020 ENOG4106TNF Periplasmic binding protein HJW72_24025 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HJW72_24030 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HJW72_24035 ENOG4105DJ4 phosphatidylserine decarboxylase HJW72_24040 ENOG4105EGS Mechanosensitive ion channel HJW72_24045 ENOG4107SC7 Inner membrane transporter yjeM HJW72_24050 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HJW72_24055 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HJW72_24060 ENOG4105E33 succinate dehydrogenase HJW72_24070 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HJW72_24080 ENOG4105KPY Small multidrug resistance protein HJW72_24085 ENOG4106BSU Entericidin B HJW72_24095 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HJW72_24100 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HJW72_24120 ENOG4105CW0 outer membrane usher protein HJW72_24135 ENOG4108MBX Secretion Protein HJW72_24140 ENOG4108JJA ABC, transporter HJW72_24150 ENOG4108ZVF (LipO)protein HJW72_24155 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HJW72_24165 ENOG4105DVH amino acid HJW72_24170 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HJW72_24175 ENOG4108IJ0 Aspartate ammonia-lyase HJW72_24180 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HJW72_24190 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HJW72_24195 ENOG4108SIC Transcriptional regulator HJW72_24230 ENOG4108TUY outer membrane protein PgaA HJW72_24235 ENOG4107BJW polysaccharide deacetylase HJW72_24240 ENOG4105CND Glycosyl transferase, family 2 HJW72_24260 ENOG4108ZCF integral membrane protein HJW72_24270 ENOG4105DVC DnaJ domain protein HJW72_24295 ENOG4105CT4 transporter HJW72_24300 ENOG4105F8D glycoside hydrolase family 4 HJW72_24305 ENOG4108K2B transcriptional regulator HJW72_24310 ENOG4105CSH Transporter HJW72_24315 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HJW72_24320 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HJW72_24325 ENOG4107RJJ Transcriptional regulator HJW72_24330 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HJW72_24335 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HJW72_24340 ENOG4105EKV Phosphonate metabolism protein HJW72_24345 ENOG4105FT8 Phosphonate metabolism HJW72_24350 ENOG4105ENV phosphonate C-P lyase system protein PhnK HJW72_24355 ENOG4105HRV phosphonate c-p lyase system protein phnl HJW72_24360 ENOG4105FD8 phosphonate metabolism protein PhnM HJW72_24365 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HJW72_24370 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HJW72_24380 ENOG4105BZU Histidine kinase HJW72_24385 ENOG4105C2J ABC transporter HJW72_24390 ENOG4105CNN ABC, transporter HJW72_24395 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HJW72_24430 ENOG41082ND Uncharacterized protein yjcO HJW72_24435 ENOG4105CK2 sodium dicarboxylate symporter HJW72_24445 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HJW72_24450 ENOG41062QD Membrane HJW72_24455 ENOG4107QN1 sodium solute HJW72_24470 ENOG4105CW0 outer membrane usher protein HJW72_24475 ENOG4108VCD Chaperone HJW72_24480 ENOG4105MX3 Fimbrial HJW72_24490 ENOG41067MG lrgb family HJW72_24500 ENOG4105CMU LysR family (Transcriptional regulator HJW72_24505 ENOG4105EEQ Na H antiporter HJW72_24510 ENOG4105C7N Xanthine uracil vitamin C permease HJW72_24515 ENOG4108K3A Glutathione S-transferase HJW72_24520 ENOG4108Z4X TRANSCRIPTIONal HJW72_24525 ENOG4108W3Q Transcriptional regulator HJW72_24530 ENOG4108M8H domain protein HJW72_24535 ENOG4105PMV Membrane HJW72_24560 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HJW72_24565 ENOG4105ETE Transcriptional regulator (LacI family HJW72_24570 ENOG4105ECY inositol monophosphatase HJW72_24580 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HJW72_24600 ENOG4108DMH HTH_ARAC HJW72_24605 ENOG4107RNH Outer membrane receptor FepA HJW72_24615 ENOG4105E4C Lytic transglycosylase catalytic HJW72_24620 ENOG4108UUM single-stranded DNA-binding protein HJW72_24625 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HJW72_24630 ENOG4105MSB protein, conserved in bacteria HJW72_24635 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HJW72_24645 ENOG4105CGF Aromatic amino acid aminotransferase HJW72_24650 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HJW72_24655 ENOG4105CDU Replicative dna helicase HJW72_24660 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HJW72_24665 ENOG4105P4Z Phage shock protein G HJW72_24670 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HJW72_24680 ENOG4105MYN Zinc uptake regulation protein HJW72_24685 ENOG4105VDW Csbd family HJW72_24695 ENOG4107R73 Mate efflux family protein HJW72_24700 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HJW72_24705 ENOG41080IJ Diacylglycerol kinase HJW72_24710 ENOG4105E55 glycerol-3-phosphate acyltransferase HJW72_24715 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HJW72_24720 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HJW72_24725 ENOG4107W52 maltose operon periplasmic protein HJW72_24730 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HJW72_24735 ENOG4108IJ9 (ABC) transporter HJW72_24740 ENOG4107FKK extracellular solute-binding protein family 1 HJW72_24745 ENOG4105D56 permease protein HJW72_24750 ENOG4105EG2 ABC transporter, permease HJW72_24755 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HJW72_24760 ENOG4105CEM UPF0597 protein HJW72_24775 ENOG4105KME endoribonuclease L-psp HJW72_24785 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HJW72_24790 ENOG4107QP8 phosphohexose isomerase HJW72_24795 ENOG4105CFH Aspartokinase HJW72_24800 ENOG4105C09 Bile acid HJW72_24805 ENOG4108ZR5 Conserved Protein HJW72_24810 ENOG4105FE9 pseudouridine synthase HJW72_24820 ENOG4105EAM Na Pi-cotransporter HJW72_24825 ENOG4105C3R Methionine synthase HJW72_24830 ENOG41069M3 Transcriptional regulator HJW72_24835 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HJW72_24840 ENOG4108I9X Isocitrate lyase HJW72_24845 ENOG4107QP3 malate synthase g HJW72_24850 ENOG4105CVG Homoserine O-transsuccinylase HJW72_24855 ENOG4105K5X acetyltransferase HJW72_24880 ENOG4105DC1 bifunctional purine biosynthesis protein purh HJW72_24885 ENOG4105C12 Phosphoribosylglycinamide synthetase HJW72_24895 ENOG4105BZU Histidine kinase HJW72_24900 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HJW72_24905 ENOG4108T8B Protein of unknown function (DUF1481) HJW72_24910 ENOG4105K70 DNA-binding protein HJW72_24915 ENOG4105R2J Conserved Protein HJW72_24920 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HJW72_24925 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HJW72_24930 ENOG4105E09 nadh pyrophosphatase HJW72_24935 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HJW72_24940 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HJW72_24945 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HJW72_24950 ENOG4105D06 uba thif-type nad fad binding protein HJW72_24955 ENOG4105WHD thiamine biosynthesis protein ThiS HJW72_24960 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HJW72_24965 ENOG4105D41 biosynthesis protein thiH HJW72_24970 ENOG4106TD9 Diguanylate cyclase HJW72_24980 ENOG4105VCP PTS System HJW72_24985 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HJW72_24990 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HJW72_24995 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HJW72_25000 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HJW72_25005 ENOG4108VZM 50s ribosomal protein L10 HJW72_25010 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HJW72_25015 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HJW72_25020 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HJW72_25025 ENOG4105PM1 preprotein translocase subunit SecE HJW72_25030 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HJW72_25055 ENOG4105CS9 pantothenic acid kinase HJW72_25060 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HJW72_25065 ENOG4105D4A Cell wall formation (By similarity) HJW72_25095 ENOG4108RR8 protoporphyrinogen oxidase HJW72_25100 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HJW72_25105 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HJW72_25110 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) HJW72_25115 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) HJW72_25120 ENOG4105CHU acetyl-coa acetyltransferase HJW72_25125 ENOG4107QK7 reductase HJW72_25130 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HJW72_25140 ENOG4105MDZ Transcriptional activator rfaH HJW72_25150 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HJW72_25155 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HJW72_25160 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HJW72_25165 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HJW72_25170 ENOG4105JC1 sterol-binding domain protein HJW72_25175 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HJW72_25180 ENOG4105CGY Dna recombination protein HJW72_25185 ENOG4107SXA Phosphorylase HJW72_25190 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HJW72_25195 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HJW72_25200 ENOG4105DZ2 Transcriptional regulator HJW72_25205 ENOG4105EMK carboxylate amino acid amine transporter HJW72_25210 ENOG4105DQF Hydrolase HJW72_25215 ENOG4108EUD Lysophospholipase HJW72_25220 ENOG410829K Lysine exporter protein (Lyse ygga) HJW72_25230 ENOG4105CCF Lysine exporter protein (Lyse ygga) HJW72_25235 ENOG4105C9U ATP-dependent DNA helicase RecQ HJW72_25240 ENOG4105HDD phospholipase HJW72_25245 ENOG4108VUY thioesterase Superfamily protein HJW72_25250 ENOG4105FR1 rard protein HJW72_25255 ENOG4107QUT magnesium and cobalt transport protein CorA HJW72_25260 ENOG4105C4R Atp-dependent dna helicase HJW72_25265 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HJW72_25270 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HJW72_25275 ENOG4105CT0 Protein of unknown function, DUF484 HJW72_25285 ENOG4105S7Z (LipO)protein HJW72_25290 ENOG4105XQ6 frataxin-like protein HJW72_25295 ENOG4107T0K Adenylate cyclase HJW72_25300 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HJW72_25305 ENOG41076E6 Uroporphyrinogen-III Synthase HJW72_25310 ENOG4105ECF c-methyltransferase HJW72_25315 ENOG410601J HemY protein HJW72_25345 ENOG4105C85 amino acid HJW72_25350 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HJW72_25355 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HJW72_25360 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HJW72_25365 ENOG4105EGZ biosynthesis protein HJW72_25370 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HJW72_25375 ENOG4108WJ1 acetyltransferase HJW72_25380 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HJW72_25385 ENOG4105C1B dTDP-glucose 4-6-dehydratase HJW72_25390 ENOG4107QQG Dehydrogenase HJW72_25395 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HJW72_25400 ENOG4105SFE lipopolysaccharide biosynthesis protein HJW72_25405 ENOG4105ESV Glycosyl transferase, family 4 HJW72_25410 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HJW72_25420 ENOG4105C1J atp-dependent rna helicase HJW72_25425 ENOG4105C9X ppx gppa phosphatase HJW72_25440 ENOG4108UQV Membrane HJW72_25445 ENOG4105C4R Atp-dependent dna helicase HJW72_25450 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HJW72_25455 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HJW72_25460 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HJW72_25465 ENOG4105EMY transcriptional regulator HJW72_25470 ENOG4105C7B Threonine dehydratase HJW72_25475 ENOG4105C01 Dihydroxy-acid dehydratase HJW72_25480 ENOG4105CM2 brancheD-chain amino acid aminotransferase HJW72_25485 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HJW72_25500 ENOG4105C0P Mg chelatase subunit ChlI HJW72_25505 ENOG4108WFC UPF0438 protein yifE HJW72_25560 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HJW72_25565 ENOG4108Y73 Membrane HJW72_25570 ENOG4105EJ2 Transcriptional regulator HJW72_25575 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HJW72_25580 ENOG4105C5Q Transcriptional regulator HJW72_25585 ENOG4105CH7 arginosuccinase HJW72_25590 ENOG4105CAS nag kinase HJW72_25595 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HJW72_25610 ENOG4108MEK Metal-binding protein YodA HJW72_25615 ENOG4106R3P AraC family transcriptional regulator HJW72_25620 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HJW72_25625 ENOG4105DCT glycerol dehydrogenase HJW72_25630 ENOG4108Q5Y Membrane HJW72_25635 ENOG4105SYT Methylenetetrahydrofolate reductase HJW72_25640 ENOG4105CN8 Transcriptional regulator HJW72_25645 ENOG4108Z8I decarboxylase HJW72_25670 ENOG4105CFH Aspartokinase HJW72_25675 ENOG4105C28 cystathionine HJW72_25680 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HJW72_25685 ENOG4105VFB Binds the 23S rRNA (By similarity) HJW72_25690 ENOG4105C25 Primosomal protein n' HJW72_25695 ENOG4105ETE Transcriptional regulator (LacI family HJW72_25700 ENOG41063M6 Cell Division Protein HJW72_25705 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HJW72_25715 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HJW72_25720 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HJW72_25725 ENOG4105CTQ phosphohexokinase HJW72_25730 ENOG41076HS cation diffusion facilitator family transporter HJW72_25735 ENOG4105FMW periplasmic HJW72_25740 ENOG4105E3W Two component transcriptional regulator (Winged helix family HJW72_25745 ENOG4105E0F Histidine kinase HJW72_25750 ENOG4108RPX mosc domain containing protein HJW72_25755 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HJW72_25760 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HJW72_25765 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HJW72_25770 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HJW72_25775 ENOG4105DET Rhamnulokinase HJW72_25780 ENOG4105DKG l-rhamnose isomerase HJW72_25785 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) HJW72_25790 ENOG4105D4B ABC, transporter HJW72_25795 ENOG4105C2J ABC transporter HJW72_25800 ENOG4105CNN ABC, transporter HJW72_25805 ENOG4105CNN ABC, transporter HJW72_25810 ENOG4105C0A alcohol dehydrogenase HJW72_25820 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HJW72_25855 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HJW72_25865 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HJW72_25870 ENOG4108MG3 formate dehydrogenase HJW72_25875 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HJW72_25885 ENOG41068KX affects formate dehydrogenase-N HJW72_25895 ENOG4105SUU thioesterase domain HJW72_25900 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HJW72_25905 ENOG4107S2Z UPF0761 membrane protein HJW72_25910 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HJW72_25915 ENOG4105CI3 gtp-binding protein typa HJW72_25920 ENOG4105C5F glutamine synthetase HJW72_25925 ENOG4105CUX Signal transduction histidine kinase HJW72_25930 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HJW72_25935 ENOG4106FIY HJW72_25940 ENOG4105D4P Coproporphyrinogen iii oxidase HJW72_25945 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HJW72_25950 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HJW72_25955 ENOG4105C2M dna polymerase I HJW72_25960 ENOG4106HNH Acyl-transferase HJW72_25965 ENOG4108Z33 Thiol disulfide Interchange Protein HJW72_25970 ENOG4105E27 serine threonine protein kinase HJW72_25975 ENOG4105PC1 Conserved Protein HJW72_25980 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HJW72_25985 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HJW72_26010 ENOG4107EJG GntR family transcriptional regulator HJW72_26015 ENOG4105C0R drug resistance transporter emrb qaca subfamily HJW72_26020 ENOG4105ETE Transcriptional regulator (LacI family HJW72_26025 ENOG4108RVA ribokinase HJW72_26030 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HJW72_26035 ENOG4105CNN ABC, transporter HJW72_26040 ENOG4105C2J ABC transporter HJW72_26050 ENOG4105DFH Transport of potassium into the cell (By similarity) HJW72_26065 ENOG4105CU9 asparagine synthetase A HJW72_26070 ENOG4108VVK transcriptional Regulator, AsnC HJW72_26075 ENOG4105QTB Flavodoxin HJW72_26080 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HJW72_26085 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HJW72_26090 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HJW72_26110 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HJW72_26115 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HJW72_26120 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HJW72_26125 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HJW72_26130 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HJW72_26150 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HJW72_26155 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HJW72_26160 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HJW72_26165 ENOG4105C8U phosphate abc transporter HJW72_26170 ENOG4105E2Z phosphate ABC transporter (Permease HJW72_26175 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HJW72_26195 ENOG4105DYC esterase HJW72_26200 ENOG4107VKM 6-phosphogluconolactonase HJW72_26205 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HJW72_26215 ENOG4105C7N Xanthine uracil vitamin C permease HJW72_26220 ENOG4108YYH Nadph-dependent fmn reductase HJW72_26225 ENOG4105E8Q phosphopantetheinyl transferase HJW72_26235 ENOG4105C2C drug resistance transporter, Bcr CflA HJW72_26245 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HJW72_26250 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HJW72_26255 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HJW72_26265 ENOG4105VG0 50S ribosomal protein l34 HJW72_26270 ENOG4106CQM replication HJW72_26275 ENOG4108BUD transposase HJW72_26295 ENOG4108BUD transposase HJW72_26335 ENOG4108BUD transposase HJW72_26355 ENOG4108BUD transposase HJW72_26380 ENOG4108BUD transposase HJW72_26475 ENOG4105VUN Transcriptional regulator HJW72_26485 ENOG4108BUD transposase HJW72_26515 ENOG4108BUD transposase HJW72_26520 ENOG4108C33 Resolvase HJW72_26525 ENOG4108RAV Conserved protein HJW72_26555 ENOG4105T95 Thiol disulfide interChange protein HJW72_26680 ENOG41073YN Protein of unknown function (DUF1380) HJW72_26685 ENOG4106JQ7 HJW72_26710 ENOG4105MPK DNA polymerase III subunit theta HJW72_26765 ENOG4105FEQ ParB domain protein nuclease HJW72_26790 ENOG41074AV Hok/gef family HJW72_26860 ENOG4108Z3N Transcriptional regulator HJW72_27085 ENOG4107CBI conjugal transfer fertility inhibition protein HJW72_27115 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) HJW72_27155 ENOG4105VDM plasmid maintenance system antidote protein, xre family HJW72_27175 ENOG4105MZG transcriptional modulator of maze toxin, mazf