locus-tag class description AM488_00010 ENOG4105WJ3 XRE family Transcriptional regulator AM488_00180 ENOG4107QJE Chromosome Partitioning Protein AM488_00260 ENOG4105ED1 spovr family AM488_00265 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) AM488_00270 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AM488_00285 ENOG4108ZZ3 UPF0260 protein AM488_00290 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AM488_00295 ENOG4105VNG YcgL domain-containing protein AM488_00300 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AM488_00305 ENOG4107QMS site-determining protein AM488_00310 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) AM488_00315 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) AM488_00320 ENOG4105CEY Amp-dependent synthetase and ligase AM488_00325 ENOG4105Y4Z Outer Membrane Lipoprotein AM488_00330 ENOG41072GX Peptidase M22 Glycoprotease AM488_00350 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM488_00355 ENOG4105D0M Protease HtpX homolog AM488_00360 ENOG4105CN1 protease AM488_00365 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) AM488_00370 ENOG4108ZGC gaf domain protein AM488_00375 ENOG4105H2K paraquat-inducible protein a AM488_00380 ENOG4105DY2 Paraquat-inducible protein b AM488_00385 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AM488_00390 ENOG4105WT8 Protein of unknown function (DUF1480) AM488_00395 ENOG4105UVW uncharacterized protein yebW AM488_00400 ENOG4108R1E Serine threonine protein phosphatase 1 AM488_00405 ENOG4108MJ5 VirK protein AM488_00410 ENOG4105F2I Transposase AM488_00420 ENOG4105NKT exported protein AM488_00425 ENOG4108PNC copper resistance AM488_00430 ENOG4105FXM Copper resistance protein AM488_00435 ENOG4105MPK DNA polymerase III subunit theta AM488_00440 ENOG4105UMD exodeoxyribonuclease X AM488_00445 ENOG4105CUG Oligopeptidase b AM488_00450 ENOG4108Q2J Inner membrane protein YebE AM488_00455 ENOG4105X2V dna damage-inducible protein AM488_00465 ENOG4108UHU Aldolase AM488_00470 ENOG4105C01 Dihydroxy-acid dehydratase AM488_00475 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AM488_00490 ENOG4106KNT transcriptional regulator AM488_00495 ENOG4105CA9 Pyruvate kinase AM488_00500 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase AM488_00505 ENOG4105DR5 peptidase AM488_00510 ENOG4105NXV High-affinity zinc uptake system protein AM488_00520 ENOG4105FAV ABC, transporter AM488_00525 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AM488_00535 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AM488_00545 ENOG4108TIT dATP pyrophosphohydrolase AM488_00550 ENOG4105C9M aspartyl-trna synthetase AM488_00555 ENOG4105D3W isochorismatase AM488_00560 ENOG41081XQ Conserved Protein AM488_00565 ENOG4105WJG Glutathione AM488_00570 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) AM488_00575 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AM488_00580 ENOG4106N3A copper homeostasis protein cutc AM488_00585 ENOG4106ZCM YecM protein AM488_00590 ENOG4105C75 arginyL-tRNA synthetase AM488_00595 ENOG4105F5H Glycosyl Hydrolase Family 88 AM488_00600 ENOG4105CT4 transporter AM488_00605 ENOG4108VA4 Universal stress protein AM488_00610 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase AM488_00620 ENOG4105CNN ABC, transporter AM488_00630 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator AM488_00640 ENOG4108UEC Ferritin-like protein AM488_00655 ENOG4105N4N Protein of unknown function (DUF2766) AM488_00660 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM488_00675 ENOG41090A1 ferritin AM488_00680 ENOG4105VVZ metal-binding protein AM488_00685 ENOG4105E0U tyrosine-specific transport protein AM488_00690 ENOG4106RHG Yeca family AM488_00720 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AM488_00730 ENOG4105WH1 Two component transcriptional regulator luxr family AM488_00735 ENOG4105XVG cytoplasmic protein AM488_00740 ENOG4105VJY transcriptional regulator AM488_00745 ENOG4105CDA abc transporter atp-binding protein AM488_00750 ENOG4105E5Q amino acid AbC transporter AM488_00755 ENOG4105K6H D-cysteine desulfhydrase AM488_00760 ENOG4105EAB amino acid AbC transporter AM488_00765 ENOG4105E5K Alpha-amylase AM488_00770 ENOG4105JCU Inherit from NOG: (Lipo)protein AM488_00785 ENOG4105YX3 cellular response to acidity AM488_00795 ENOG4105CKW Inner membrane protein yedI AM488_00800 ENOG4105FDR Membrane AM488_00805 ENOG41090BB DNA mismatch endonuclease (vsr) AM488_00810 ENOG4105DVF Cytosine-specific methyltransferase AM488_00815 ENOG4105EST Metal Dependent Phosphohydrolase AM488_00820 ENOG4105Y0K Inner membrane protein YedR AM488_00830 ENOG4105FCK Membrane AM488_00840 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) AM488_00860 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AM488_00865 ENOG4107R11 Transcriptional regulator AM488_00895 ENOG4105D8D Type III AM488_01025 ENOG4105EEQ Na H antiporter AM488_01030 ENOG4108WUH Transcriptional regulator, TetR family AM488_01035 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family AM488_01055 ENOG4105FYV Amp nucleosidase AM488_01065 ENOG4105UQX Mate efflux family protein AM488_01085 ENOG4105BZU Histidine kinase AM488_01100 ENOG4105ETT transcriptional Regulator, LysR family AM488_01105 ENOG4105YP6 Domain of unknown function (DUF1869) AM488_01110 ENOG4108YS1 cytoplasmic protein AM488_01115 ENOG4105BZU Histidine kinase AM488_01130 ENOG4105CSH Transporter AM488_01135 ENOG4108KMH lipoate-protein ligase a AM488_01140 ENOG4105HEI LysR family (Transcriptional regulator AM488_01145 ENOG41090U3 tautomerase AM488_01155 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AM488_01165 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) AM488_01175 ENOG4105DR8 Membrane AM488_01185 ENOG4105DZ1 carboxypeptidase AM488_01190 ENOG4105CJB Exodeoxyribonuclease I AM488_01195 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AM488_01200 ENOG4105YVS arsR family transcriptional regulator AM488_01205 ENOG4105CUB amino acid AM488_01215 ENOG4105EQ1 Transcriptional regulator AM488_01220 ENOG4108535 NAD dependent epimerase/dehydratase family AM488_01240 ENOG4105CIH Imidazole acetol-phosphate transaminase AM488_01245 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AM488_01250 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AM488_01255 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AM488_01260 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AM488_01265 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AM488_01275 ENOG4108YXQ IS66 Orf2 family protein AM488_01280 ENOG4105E5H Transposase AM488_01305 ENOG4105EY8 ABC transporter AM488_01375 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AM488_01405 ENOG41090RK glycosyl transferase AM488_01415 ENOG4108RYC glycosyltransferase AM488_01420 ENOG4105CG5 Glycosyl transferase (Group 1 AM488_01425 ENOG4105D3Q Sugar transferase AM488_01440 ENOG4105DAY polysaccharide export protein AM488_01445 ENOG4108MRJ AM488_01450 ENOG4105MH5 phosphoesterase PA-phosphatase related protein AM488_01455 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AM488_01465 ENOG4105EE5 Membrane protein terC AM488_01470 ENOG4108GAE asmA family AM488_01485 ENOG4105D03 DNA-3-methyladenine glycosylase II AM488_01495 ENOG4105R8A Heat shock protein AM488_01515 ENOG4105CK2 sodium dicarboxylate symporter AM488_01520 ENOG4105ENT Efflux transporter rnd family, mfp subunit AM488_01525 ENOG4105BZS acriflavin resistance protein AM488_01530 ENOG4105BZS acriflavin resistance protein AM488_01535 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM488_01540 ENOG4105EB3 Histidine kinase AM488_01545 ENOG4105E3W Two component transcriptional regulator (Winged helix family AM488_01550 ENOG4105CFP Peptidase U32 AM488_01560 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 AM488_01565 ENOG4105IE8 Alpha-ketoglutarate permease AM488_01570 ENOG4105CMG Carbohydrate kinase AM488_01575 ENOG4105DEI Mannitol dehydrogenase AM488_01595 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AM488_01600 ENOG4105IE8 Alpha-ketoglutarate permease AM488_01605 ENOG4105EIE fructose-bisphosphate aldolase AM488_01610 ENOG4105DWF phosphomethylpyrimidine kinase AM488_01625 ENOG4105DUM transcriptional regulator, lysR family AM488_01630 ENOG4105CPN adenine deaminase AM488_01635 ENOG4105C7N Xanthine uracil vitamin C permease AM488_01640 ENOG4105EJC lysr family transcriptional regulator AM488_01645 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly AM488_01655 ENOG4105D1F ATP-binding protein AM488_01660 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AM488_01665 ENOG4108W15 Protein of unknown function (DUF1456) AM488_01670 ENOG4108NEV two component transcriptional regulator, LytTR family AM488_01675 ENOG4108HRK Histidine kinase AM488_01685 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component AM488_01690 ENOG4108IJ8 ABC transporter AM488_01695 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component AM488_01700 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system AM488_01705 ENOG4107QK4 glycoside hydrolase, family 3 domain protein AM488_01710 ENOG4105CXG d-lactate dehydrogenase AM488_01720 ENOG41061WM D-Alanyl-D-Alanine AM488_01725 ENOG41069YE inner membrane protein yohC AM488_01730 ENOG4105KHU inner membrane protein YohD AM488_01745 ENOG4105CS2 ec 3.2.1.21 AM488_01760 ENOG4105TW1 Carbohydrate-selective porin OprB AM488_01765 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) AM488_01770 ENOG4105VAW lrga family AM488_01775 ENOG41067MG lrgb family AM488_01780 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) AM488_01790 ENOG4107GZ4 SanA protein AM488_01795 ENOG4107SDZ Galactoside transport system permease protein mglC AM488_01800 ENOG4105C2J ABC transporter AM488_01810 ENOG41060NJ transcriptional regulator AM488_01815 ENOG4105DHF Membrane AM488_01820 ENOG4105EUJ GTP cyclohydrolase i AM488_01830 ENOG4105D05 Receptor AM488_01845 ENOG4108IQI permease AM488_01850 ENOG4105DUM transcriptional regulator, lysR family AM488_01860 ENOG4105HMI Membrane AM488_01865 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AM488_01870 ENOG4105DM4 PTS System AM488_01875 ENOG4105DE4 1-phosphofructokinase AM488_01880 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein AM488_01890 ENOG4105S8Q sugar efflux transporter AM488_01895 ENOG4105KRS Proteinase inhibitor AM488_01905 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) AM488_01910 ENOG4105DEI Mannitol dehydrogenase AM488_01915 ENOG4105CKI cobalamin synthesis protein AM488_01920 ENOG41076MN Phosphoesterase, PA-phosphatase related AM488_01925 ENOG4107TT5 NLP P60 protein AM488_01930 ENOG4105CXC rtn protein AM488_01935 ENOG4105E43 Extracellular solute-binding protein, family 5 AM488_01940 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component AM488_01945 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component AM488_01950 ENOG4108JQ5 ABC transporter AM488_01955 ENOG4105HG6 AM488_01960 ENOG4105C2C drug resistance transporter, Bcr CflA AM488_01965 ENOG4105I08 Pseudouridine synthase AM488_01970 ENOG4105CFI type iii restriction protein res subunit AM488_01975 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AM488_01990 ENOG4107VIJ nudix hydrolase AM488_01995 ENOG4105N2W Transcriptional regulator AM488_02000 ENOG4106V8H Nucleoid-associated protein AM488_02005 ENOG4105PAN UPF0352 protein AM488_02010 ENOG4105E68 Sulfatase AM488_02020 ENOG4105F4G Membrane AM488_02035 ENOG4105CHH sulfate transporter AM488_02040 ENOG4105CJW magnesium transporter AM488_02045 ENOG4105IBP Cyclic peptide transporter AM488_02050 ENOG4105CF1 Alkylated DNA repair protein AM488_02055 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AM488_02070 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC AM488_02075 ENOG41068CG regulatoR AM488_02080 ENOG4105BZU Histidine kinase AM488_02085 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AM488_02090 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AM488_02100 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AM488_02105 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AM488_02110 ENOG4105XPH Ferredoxin AM488_02120 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AM488_02125 ENOG4105CXY transporter AM488_02130 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A AM488_02135 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B AM488_02140 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AM488_02145 ENOG4105CNV Aldolase AM488_02150 ENOG4105CSP Major Facilitator Superfamily AM488_02155 ENOG4105CXK mandelate racemase muconate lactonizing AM488_02160 ENOG4107258 Transcriptional regulator AM488_02170 ENOG4108UII YfaZ family AM488_02175 ENOG4105DNE Transposase AM488_02185 ENOG4105CEY Amp-dependent synthetase and ligase AM488_02190 ENOG4105DNI Converts SHCHC to OSB (By similarity) AM488_02195 ENOG4108IPT Naphthoate synthase AM488_02200 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AM488_02205 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AM488_02210 ENOG4105E4F Isochorismate synthase AM488_02215 ENOG4107YB6 acetyltransferase, (GNAT) family AM488_02220 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AM488_02225 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AM488_02230 ENOG4105C8S subunit m AM488_02235 ENOG4105D65 subunit l AM488_02245 ENOG4107UFS subunit j AM488_02260 ENOG4107R0R NADH dehydrogenase subunit g AM488_02265 ENOG4107QIZ NADH dehydrogenase AM488_02270 ENOG4105GKE subunit e AM488_02275 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AM488_02285 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AM488_02300 ENOG4107NQ8 LysR family Transcriptional regulator AM488_02305 ENOG4105CHM Aminotransferase AM488_02315 ENOG4107QWE )-transporter AM488_02320 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 AM488_02335 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AM488_02340 ENOG4105C6K Malic enzyme AM488_02345 ENOG4105PTV Nudix Hydrolase AM488_02350 ENOG4108RE9 Phosphodiesterase AM488_02355 ENOG4108SHQ Glutathione S-transferase AM488_02360 ENOG4105CYM Glutathione S-transferase AM488_02365 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase AM488_02370 ENOG4105ECP epimerase AM488_02375 ENOG4105KNA -acetyltransferase AM488_02380 ENOG4108JEH abc transporter atp-binding protein AM488_02385 ENOG4106YG3 ABC transporter AM488_02390 ENOG4105DSP amino acid AbC transporter AM488_02395 ENOG4105E89 ABC transporter AM488_02400 ENOG4105E89 ABC transporter AM488_02405 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AM488_02410 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AM488_02415 ENOG4105E96 Colicin v production protein AM488_02420 ENOG4108S3P Sporulation domain protein AM488_02425 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AM488_02430 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AM488_02435 ENOG4105DQR SNARE associated Golgi AM488_02440 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AM488_02445 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AM488_02455 ENOG4106WZ1 flagella biosynthesis regulator AM488_02460 ENOG4105F9N Major Facilitator Superfamily AM488_02465 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AM488_02470 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AM488_02475 ENOG4105MH2 YfcL protein AM488_02480 ENOG4108BPE -transporting atpase AM488_02485 ENOG4105EJ9 Membrane AM488_02490 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) AM488_02495 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AM488_02500 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AM488_02505 ENOG4108DG9 Smr protein MutS2 AM488_02510 ENOG4108BY2 phosphohistidine phosphatase AM488_02515 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AM488_02520 ENOG4105CHU acetyl-coa acetyltransferase AM488_02525 ENOG4105KZW UPF0381 protein AM488_02535 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AM488_02540 ENOG410903C (LipO)protein AM488_02545 ENOG4105S64 Formate nitrite transporter AM488_02565 ENOG4105DND Transcriptional regulator AM488_02570 ENOG4107Y2X deaminase AM488_02575 ENOG4105DJ2 Major Facilitator Superfamily AM488_02585 ENOG4105CHM Aminotransferase AM488_02595 ENOG4108HRK Histidine kinase AM488_02600 ENOG4105DY9 regulatoR AM488_02605 ENOG4105CHC glucokinase (EC 2.7.1.2) AM488_02615 ENOG4107RA9 decarboxylase AM488_02620 ENOG4105CPC Aldo Keto reductase AM488_02625 ENOG4109076 Conserved Protein AM488_02630 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AM488_02635 ENOG4105D9N nucleoside AM488_02640 ENOG4108KMM Diguanylate cyclase AM488_02655 ENOG4105HZG regulatoR AM488_02660 ENOG4105GXM Putative transcription regulator (DUF1323) AM488_02665 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AM488_02695 ENOG4108M0I Transcriptional regulator AM488_02700 ENOG4105DHU Bile acid AM488_02705 ENOG4105VRT cytoplasmic protein AM488_02710 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AM488_02715 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) AM488_02720 ENOG4105EXN Sulfate transport protein CysZ AM488_02725 ENOG4105C6T cysteine synthase AM488_02730 ENOG4105KZ7 phosphocarrier protein hpr AM488_02740 ENOG4105C5Y PTS System AM488_02755 ENOG4105CSW GntR family transcriptional regulator AM488_02760 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein AM488_02765 ENOG4105C6T cysteine synthase AM488_02770 ENOG4108IJ6 ABC transporter AM488_02775 ENOG4105ECW sulfate abc transporter AM488_02780 ENOG4108I5D sulfate abc transporter AM488_02785 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein AM488_02795 ENOG4105EZR dyp-type peroxidase family protein AM488_02800 ENOG4105E7K (LipO)protein AM488_02805 ENOG4105QZU Inner membrane protein YfeZ AM488_02815 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase AM488_02820 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AM488_02825 ENOG4108K3Z AraC family transcriptional regulator AM488_02830 ENOG4108X49 Ethanolamine utilization protein EutK AM488_02835 ENOG4106D67 ethanolamine utilization protein AM488_02845 ENOG4105CPD ethanolamine ammonia-lyase AM488_02850 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase AM488_02855 ENOG4105ENY Ethanolamine utilization protein eutH AM488_02860 ENOG4105C0A alcohol dehydrogenase AM488_02865 ENOG4107RWI ethanolamine utilization protein eutJ AM488_02870 ENOG4108EKI Dehydrogenase AM488_02875 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml AM488_02880 ENOG4105KNY Microcompartments protein AM488_02885 ENOG4108IJ2 phosphate acetyltransferase AM488_02890 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase AM488_02895 ENOG4105NDK ethanolamine utilization protein AM488_02900 ENOG4106S4J ethanolamine utilization protein EutP AM488_02905 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place AM488_02910 ENOG4105C6K Malic enzyme AM488_02915 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AM488_02920 ENOG4105CV1 Transketolase (EC 2.2.1.1) AM488_02925 ENOG4108PVD exported protein AM488_02930 ENOG4107VIJ nudix hydrolase AM488_02935 ENOG4105BZ8 glutamate synthase AM488_02945 ENOG4105BZS acriflavin resistance protein AM488_02955 ENOG4105KUZ arsenate reductase AM488_02960 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AM488_02965 ENOG4105XYK UPF0370 protein AM488_02970 ENOG4106KED esterase YpfH AM488_02975 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) AM488_02980 ENOG4105CGZ zinc metallopeptidase AM488_02990 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AM488_02995 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AM488_03000 ENOG4105RH4 Glycine cleavage system transcriptional repressor AM488_03005 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AM488_03010 ENOG4105C02 permease AM488_03015 ENOG4105ERG peptidase m48, ste24p AM488_03020 ENOG4105K89 arsenate reductase AM488_03035 ENOG4105C2W permease AM488_03040 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AM488_03045 ENOG4105CS2 ec 3.2.1.21 AM488_03050 ENOG41066F8 ROK family AM488_03055 ENOG4105CXB phosphoribosylaminoimidazole synthetase AM488_03060 ENOG4108V3E phosphoribosylglycinamide formyltransferase AM488_03065 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AM488_03070 ENOG4105C9X ppx gppa phosphatase AM488_03075 ENOG4105BZU Histidine kinase AM488_03080 ENOG41062G3 Protein of unknown function (DUF2633) AM488_03095 ENOG4105C4X radical SAM domain protein AM488_03105 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AM488_03110 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AM488_03115 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AM488_03120 ENOG4105VPD cellular component movement AM488_03130 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AM488_03135 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AM488_03140 ENOG4105N21 Membrane AM488_03150 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AM488_03155 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) AM488_03160 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AM488_03175 ENOG4108JQB penicillin-binding protein 1C AM488_03180 ENOG4105DN3 alpha-2-macroglobulin domain protein AM488_03185 ENOG4105KHC sulfurtransferase AM488_03195 ENOG4105YYA enhanced serine sensitivity protein SseB AM488_03200 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AM488_03205 ENOG4105WVQ Fe-S assembly protein IscX AM488_03210 ENOG4108ZIT Ferredoxin, 2FE-2S AM488_03215 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB AM488_03220 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) AM488_03225 ENOG4108Z4V iron-sulfur cluster assembly AM488_03230 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AM488_03235 ENOG4105C3J Cysteine desulfurase AM488_03240 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AM488_03245 ENOG4105CVS RNA methyltransferase TrmH family, group 1 AM488_03250 ENOG4105ECY inositol monophosphatase AM488_03260 ENOG4105D7X high-affinity nickel-transporter AM488_03265 ENOG41065CD Exported protein AM488_03270 ENOG4108MN2 Stationary phase inducible protein CsiE AM488_03275 ENOG4105D8G Major Facilitator superfamily AM488_03280 ENOG4108ZKT aldose 1-epimerase AM488_03285 ENOG4107QNK )-transporter AM488_03295 ENOG4108NZE NAGC-like transcriptional regulator AM488_03300 ENOG4108SB3 DoxX Family AM488_03305 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AM488_03315 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AM488_03320 ENOG4108YZA Nitrogen regulatory protein pii AM488_03325 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AM488_03330 ENOG4108SKK alpha helix protein AM488_03335 ENOG4107WP9 Histidine kinase AM488_03340 ENOG4108ETH Formylglycinamide ribotide synthetase AM488_03345 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AM488_03350 ENOG4108Z6B deaminase AM488_03355 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB AM488_03360 ENOG4106G6Q Transcriptional regulator AM488_03365 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AM488_03370 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AM488_03375 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AM488_03380 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) AM488_03385 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AM488_03395 ENOG4105C3F Signal peptidase i AM488_03400 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AM488_03405 ENOG4105WMJ Positive regulator of sigma E, RseC MucC AM488_03410 ENOG4105VQK sigma E regulatory protein, MucB RseB AM488_03415 ENOG41069PW sigma-e factor negative regulatory protein AM488_03425 ENOG4108IYU L-aspartate oxidase AM488_03430 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) AM488_03435 ENOG4105C1J atp-dependent rna helicase AM488_03445 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AM488_03450 ENOG4105EIB trna rrna methyltransferase AM488_03455 ENOG4105K63 Thioredoxin AM488_03460 ENOG4106IUH DTW domain containing protein AM488_03465 ENOG4105CD5 CoA-binding domain protein AM488_03470 ENOG4105JIM Phosphatidylserine synthase AM488_03475 ENOG4105T42 (LipO)protein AM488_03480 ENOG4105CSH Transporter AM488_03505 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AM488_03510 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AM488_03515 ENOG4105C34 Pseudouridine synthase AM488_03520 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AM488_03525 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA AM488_03535 ENOG4105CQC Prephenate dehydratase AM488_03545 ENOG4105EHE chorismate mutase- prephenate dehydrogenase AM488_03550 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AM488_03555 ENOG4108WS1 AM488_03560 ENOG4108KHX Diguanylate cyclase AM488_03565 ENOG41090EK ompa motb domain protein AM488_03580 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AM488_03585 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AM488_03590 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AM488_03595 ENOG4105K5M 30s ribosomal protein S16 AM488_03600 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AM488_03605 ENOG4106KVJ cytochrome C assembly protein AM488_03610 ENOG4108JU6 CBS domain protein AM488_03615 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AM488_03630 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AM488_03635 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AM488_03645 ENOG4108Z1B Cyclase dehydrase AM488_03675 ENOG4105UEI Transcriptional Regulator AraC Family AM488_03680 ENOG4105C1P efflux transporter, rnd family, mfp subunit AM488_03695 ENOG4105EVZ LysR family transcriptional regulator AM488_03700 ENOG4105CYW agmatinase AM488_03715 ENOG4106TNF Periplasmic binding protein AM488_03725 ENOG4105MP9 class II Aldolase AM488_03730 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AM488_03735 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AM488_03750 ENOG4108WQH regulatoR AM488_03755 ENOG4106EAR Fimbrial protein AM488_03760 ENOG4106P2F Pfam:Pili_assembly_C AM488_03765 ENOG4105CW0 outer membrane usher protein AM488_03780 ENOG4105CW0 outer membrane usher protein AM488_03785 ENOG4108VCD Chaperone AM488_03790 ENOG4105X0I Fimbrial AM488_03795 ENOG4105C26 Dehydrogenase AM488_03800 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AM488_03805 ENOG4105CC0 LysR family Transcriptional regulator AM488_03815 ENOG41080HT Transcriptional regulator, arsr family AM488_03820 ENOG4108V62 Rhodanese domain protein AM488_03835 ENOG4108X73 DNA- binding protein AM488_03850 ENOG4108RNS Exports L-alanine (By similarity) AM488_03855 ENOG4108WMJ Protein of unknown function (DUF2002) AM488_03860 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) AM488_03865 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AM488_03870 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AM488_03875 ENOG4105WAZ (Glutaredoxin-like protein) NrdH AM488_03880 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AM488_03885 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AM488_03890 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AM488_03895 ENOG4108IJ7 Glycine betaine AM488_03900 ENOG4108HQS Glycine betaine AM488_03905 ENOG4105GIJ Glycine betaine AM488_03910 ENOG4108UMN azlc family AM488_03915 ENOG4105ZED uncharacterized protein ygaH AM488_03920 ENOG4105NTK Transcriptional repressor Mpra AM488_03925 ENOG4105CW7 secretion protein, HlyD family AM488_03930 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM488_03935 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AM488_03950 ENOG4105D9M gamma-glutamylcysteine synthetase AM488_03955 ENOG4105W39 Membrane AM488_03960 ENOG4107VXZ Hydrolase AM488_03965 ENOG4105K3G Periplasmic Protein AM488_03995 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AM488_04000 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AM488_04005 ENOG4105Y3E Modulates RecA activity (By similarity) AM488_04010 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AM488_04015 ENOG4107TH8 cina domain protein AM488_04025 ENOG4105CC5 ABC transporter AM488_04040 ENOG4105CVE Lytic murein transglycosylase AM488_04045 ENOG410787A Pts system, glucitol sorbitol-specific AM488_04050 ENOG4105DZY Pts system, glucitol sorbitol-specific AM488_04055 ENOG4105VI0 Pts system, glucitol sorbitol-specific AM488_04060 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase AM488_04065 ENOG4105J92 DNA-binding transcriptional activator GutM AM488_04070 ENOG410804X Transcriptional regulator AM488_04080 ENOG4108JUA Transcriptional regulator AM488_04090 ENOG4105CNW domain protein AM488_04095 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase AM488_04105 ENOG4105C8H hydrogenase maturation protein Hypf AM488_04110 ENOG4108RC0 Electron transport protein AM488_04115 ENOG4105DDV Transcriptional regulator (LacI family AM488_04120 ENOG4105C5Y PTS System AM488_04125 ENOG4105CS2 ec 3.2.1.21 AM488_04135 ENOG4108MG9 hydrogenase 3 maturation protease AM488_04140 ENOG4105I6X formate hydrogenlyase maturation AM488_04145 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit AM488_04150 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit AM488_04155 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AM488_04160 ENOG4107TDF Formate hydrogenlyase subunit 4 AM488_04165 ENOG4107R30 NADH dehydrogenase AM488_04170 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) AM488_04180 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA AM488_04185 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) AM488_04190 ENOG4107RSS Hydrogenase accessory protein HypB AM488_04195 ENOG41083WG hydrogenase assembly chaperone AM488_04200 ENOG4105CQS hydrogenase expression formation protein HypD AM488_04205 ENOG4105C45 hydrogenase expression formation protein (HypE) AM488_04215 ENOG4105CS2 ec 3.2.1.21 AM488_04225 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) AM488_04235 ENOG4105CK1 PTS System AM488_04240 ENOG4105VZJ PTS System AM488_04245 ENOG4105CK1 PTS System AM488_04250 ENOG4105VCP PTS System AM488_04255 ENOG4105DKQ ROK family AM488_04260 ENOG4105DDV Transcriptional regulator (LacI family AM488_04265 ENOG4105DSE periplasmic solute binding protein AM488_04270 ENOG4105DIK (ABC) transporter AM488_04275 ENOG4105CC5 ABC transporter AM488_04280 ENOG4105CC5 ABC transporter AM488_04285 ENOG4105VXR cytoplasmic protein AM488_04295 ENOG4108N2Y auxin Efflux AM488_04315 ENOG4106QJH hemin transport protein AM488_04320 ENOG4107R4I Periplasmic binding protein AM488_04325 ENOG4105EHG Permease protein AM488_04330 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AM488_04350 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AM488_04355 ENOG4107635 Hok Gef family protein AM488_04365 ENOG4105KZM cytoplasmic protein AM488_04370 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AM488_04375 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AM488_04400 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AM488_04405 ENOG4108K5P (LipO)protein AM488_04410 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AM488_04420 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) AM488_04425 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AM488_04430 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AM488_04440 ENOG4105N0Z inner membrane protein ygbE AM488_04460 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AM488_04465 ENOG4108MXK alkaline phosphatase isozyme conversion AM488_04470 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AM488_04475 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AM488_04480 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AM488_04485 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AM488_04490 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AM488_04500 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AM488_04505 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AM488_04510 ENOG4105DXN mazG family AM488_04515 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AM488_04520 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AM488_04525 ENOG4105BZU Histidine kinase AM488_04535 ENOG4105BZW Glycerate kinase AM488_04540 ENOG4105EQX glucarate dehydratase AM488_04545 ENOG4105EQX glucarate dehydratase AM488_04550 ENOG4105DJB Major Facilitator Superfamily AM488_04555 ENOG4105QDK Flavodoxin AM488_04560 ENOG4105DR9 pseudouridine synthase AM488_04565 ENOG4105WP7 tRNA pseudouridine synthase C AM488_04570 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) AM488_04575 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AM488_04580 ENOG4105EWT decarboxylase family AM488_04585 ENOG4105C44 Serine transporter AM488_04590 ENOG4105EJQ L-serine dehydratase AM488_04595 ENOG4105GVF (ABC) transporter AM488_04605 ENOG41079KZ Major Facilitator Superfamily AM488_04615 ENOG4105D01 (LipO)protein AM488_04620 ENOG4108UMI ABC transporter, permease AM488_04625 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AM488_04640 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AM488_04645 ENOG4108JU7 Transcriptional regulator AM488_04655 ENOG4105C0A alcohol dehydrogenase AM488_04660 ENOG4107W7X Aldolase AM488_04665 ENOG4105EDR glucose galactose transporter AM488_04670 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) AM488_04675 ENOG4105CMG Carbohydrate kinase AM488_04680 ENOG4105NWF RbsD or FucU transport AM488_04685 ENOG4107EDW L-fucose operon activator AM488_04695 ENOG4105M08 Membrane AM488_04700 ENOG4105ETT transcriptional Regulator, LysR family AM488_04705 ENOG4105M5B (LipO)protein AM488_04710 ENOG4105C9B Cysteine desulfurase AM488_04715 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AM488_04720 ENOG4105CUZ uba thif-type nad fad binding protein AM488_04725 ENOG4105CA3 membrane-bound lytic murein transglycosylase AM488_04755 ENOG4108YZT Adenosylcobinamide kinase AM488_04760 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AM488_04770 ENOG4108V4M Cobalt abc transporter AM488_04775 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) AM488_04780 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) AM488_04785 ENOG4105DVK Precorrin-2 c20-methyltransferase AM488_04790 ENOG4107PPM cobalt chelatase AM488_04795 ENOG4105QUC reductase AM488_04800 ENOG4105E4R Precorrin-3B C17-methyltransferase AM488_04805 ENOG4108P62 biosynthesis protein (CbiG) AM488_04810 ENOG4105CIA precorrin-4 C(11)-methyltransferase AM488_04815 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase AM488_04820 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase AM488_04825 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) AM488_04830 ENOG41081F0 Precorrin-8x methylmutase AM488_04835 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AM488_04840 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AM488_04845 ENOG4107XVH Transcriptional regulator AM488_04850 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AM488_04855 ENOG4105KNY Microcompartments protein AM488_04860 ENOG4105EHR propanediol utilization protein pduB AM488_04865 ENOG4105DMB glycerol dehydratase AM488_04870 ENOG4105YCI dehydratase medium subunit AM488_04875 ENOG4108ZFT Dehydratase small subunit AM488_04880 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit AM488_04890 ENOG4105KNY Microcompartments protein AM488_04895 ENOG4105KNY Microcompartments protein AM488_04910 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml AM488_04920 ENOG4108EKI Dehydrogenase AM488_04925 ENOG4108EKI Dehydrogenase AM488_04930 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) AM488_04940 ENOG4105M3W utilization protein AM488_04945 ENOG4105KTW ethanolamine utilization protein AM488_04950 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AM488_04955 ENOG4105JZC GHMP kinase AM488_04960 ENOG4107QZB decarboxylase AM488_04965 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AM488_04970 ENOG4107QZM n-acetylglutamate synthase AM488_04980 ENOG4107QYX exodeoxyribonuclease v alpha AM488_04985 ENOG4107QKA exodeoxyribonuclease V beta AM488_04990 ENOG4107QXK peptidase AM488_04995 ENOG4105DSY exodeoxyribonuclease V, gamma AM488_05000 ENOG4105RVB Prepilin peptidase dependent protein c AM488_05005 ENOG4105SEN Protein of unknown function (DUF2509) AM488_05010 ENOG4105JCS prepilin peptidase dependent protein AM488_05015 ENOG4105IPU prepilin peptidase dependent protein A AM488_05020 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AM488_05025 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AM488_05030 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase AM488_05035 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AM488_05040 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) AM488_05045 ENOG4105EE5 Membrane protein terC AM488_05050 ENOG4105SUV lipoprotein YgdR AM488_05055 ENOG4105CPC Aldo Keto reductase AM488_05060 ENOG4107S74 Lysophospholipid transporter LplT AM488_05065 ENOG4105CEY Amp-dependent synthetase and ligase AM488_05080 ENOG41060NJ transcriptional regulator AM488_05090 ENOG4107YCY Transcriptional regulator AM488_05095 ENOG4105CS2 ec 3.2.1.21 AM488_05100 ENOG4105CK1 PTS System AM488_05105 ENOG4105DDV Transcriptional regulator (LacI family AM488_05110 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AM488_05115 ENOG4105RQF LysR family Transcriptional regulator AM488_05125 ENOG4105YKW AM488_05130 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AM488_05135 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AM488_05140 ENOG4108IJ9 (ABC) transporter AM488_05155 ENOG4108HKT sucrose-6-phosphate hydrolase AM488_05160 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) AM488_05165 ENOG4106NDP Transcriptional regulator AM488_05170 ENOG4107QNK )-transporter AM488_05175 ENOG4105CHR reductase AM488_05180 ENOG4105CAZ oligogalacturonide lyase AM488_05185 ENOG4108QGT oligogalacturonate-specific porin AM488_05190 ENOG4105CHU acetyl-coa acetyltransferase AM488_05195 ENOG4105C5Q Transcriptional regulator AM488_05205 ENOG4108MHD transport protein AM488_05210 ENOG4107S5I aldo keto reductase AM488_05250 ENOG4108T1W Fimbrial subunit type 3 AM488_05260 ENOG4108KTG Membrane protein, drug metabolite transporter AM488_05265 ENOG4108ZT1 Transcriptional regulator AM488_05270 ENOG4105D7X high-affinity nickel-transporter AM488_05280 ENOG4108W9T type 1 fimbriae regulatory protein AM488_05285 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off AM488_05290 ENOG4108RQP Major type 1 subunit fimbrin AM488_05295 ENOG4108S54 Fimbrial protein AM488_05300 ENOG4108NAE Fimbrial chaperone protein AM488_05305 ENOG4105CW0 outer membrane usher protein AM488_05310 ENOG4108SQA Fimbrial AM488_05315 ENOG4108T65 Fimbrial AM488_05320 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin AM488_05330 ENOG410830R acetyltransferase AM488_05335 ENOG4105VR1 Pfam:DUF1271 AM488_05345 ENOG4105J12 Multidrug resistance protein mdtN AM488_05350 ENOG4108MI0 Resistance protein AM488_05355 ENOG4105ETP RND efflux system, outer membrane lipoprotein AM488_05360 ENOG4105V2F Uncharacterized protein yoac AM488_05365 ENOG4105DUX Transporter AM488_05370 ENOG4105K89 arsenate reductase AM488_05375 ENOG4107R5R arsenical pump membrane protein AM488_05395 ENOG4105W7K Transcriptional regulator AM488_05410 ENOG4105CPC Aldo Keto reductase AM488_05425 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM488_05435 ENOG4108K5P (LipO)protein AM488_05445 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AM488_05450 ENOG4105CRK lysyL-tRNA synthetase AM488_05460 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AM488_05465 ENOG4105T95 Thiol disulfide interChange protein AM488_05470 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AM488_05475 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) AM488_05480 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB AM488_05485 ENOG4105Y75 tpr repeat protein AM488_05495 ENOG4108UT2 hemolysin iii AM488_05500 ENOG4105N5Z UPF0267 protein AM488_05505 ENOG4108Q3X Transcriptional regulator AM488_05510 ENOG4105CS2 ec 3.2.1.21 AM488_05530 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AM488_05535 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AM488_05540 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AM488_05545 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AM488_05550 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AM488_05555 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AM488_05560 ENOG4105D0A hydroxylase AM488_05565 ENOG4107RAQ aminopeptidase AM488_05570 ENOG4105E07 UPF0149 protein AM488_05575 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) AM488_05585 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AM488_05590 ENOG4108JQ1 Dehydrogenase AM488_05595 ENOG4105E66 phosphoriboisomerase A AM488_05600 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AM488_05605 ENOG4105MPN Membrane AM488_05610 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AM488_05615 ENOG4105D64 Mechanosensitive ion channel AM488_05620 ENOG4105D2N Aldolase AM488_05630 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AM488_05635 ENOG4105CV1 Transketolase (EC 2.2.1.1) AM488_05640 ENOG4108K0D peptidase, M48 AM488_05645 ENOG4105J5J Outer membrane porin AM488_05660 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) AM488_05665 ENOG4105CHR reductase AM488_05685 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase AM488_05695 ENOG4108FUF Transcriptional regulator, IclR family AM488_05700 ENOG4105CHR reductase AM488_05750 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AM488_05755 ENOG4107QNK )-transporter AM488_05760 ENOG4105GPY SprT protein AM488_05765 ENOG4105RWS endonuclease I AM488_05770 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AM488_05775 ENOG4105D7Z glutathione synthase AM488_05780 ENOG4108UJU UPF0301 protein AM488_05785 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AM488_05790 ENOG41086KC Transcriptional regulator AM488_05795 ENOG4105CZX twitching motility protein AM488_05800 ENOG4105DFA alanine racemase domain protein AM488_05805 ENOG4108VIA integral membrane protein AM488_05810 ENOG4105VZ9 UPF0235 protein AM488_05815 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AM488_05820 ENOG4105CSA Coproporphyrinogen iii oxidase AM488_05825 ENOG4105K33 Periplasmic Protein AM488_05830 ENOG41090ED Protein with unknown function (DUF469) AM488_05835 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AM488_05840 ENOG4105CEN a g-specific adenine glycosylase AM488_05845 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) AM488_05850 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division AM488_05855 ENOG4105EAA nucleoside AM488_05860 ENOG4105CXN decarboxylase AM488_05870 ENOG4108UQV Membrane AM488_05905 ENOG4105MFG Antirestriction protein AM488_05940 ENOG4105HVQ Regulatory factor of maltose metabolism AM488_05945 ENOG4105VEQ Cold shock protein AM488_05955 ENOG4105HVQ Regulatory factor of maltose metabolism AM488_06225 ENOG4105C28 cystathionine AM488_06230 ENOG4105CC0 LysR family Transcriptional regulator AM488_06250 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AM488_06255 ENOG4106032 Glutathionylspermidine synthase AM488_06265 ENOG4105CYM Glutathione S-transferase AM488_06270 ENOG410900S Protein of unknown function (DUF2623) AM488_06280 ENOG4108TEB UPF0114 protein AM488_06285 ENOG4105E4I Glycoside hydrolase family 28 AM488_06290 ENOG4105CT4 transporter AM488_06295 ENOG4108ZZF transport protein (ExbD) AM488_06300 ENOG4105CWK Biopolymer transport protein, ExbB AM488_06310 ENOG4105C28 cystathionine AM488_06315 ENOG4108K81 inner membrane protein YghB AM488_06320 ENOG4105CF7 AraC family transcriptional regulator AM488_06325 ENOG4108I6A alcohol dehydrogenase AM488_06330 ENOG4105CV8 reductase AM488_06340 ENOG4105CCT upf0313 protein AM488_06345 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) AM488_06350 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase AM488_06355 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AM488_06360 ENOG4105F4I Transcriptional regulator AM488_06365 ENOG4105H4F exported protein AM488_06370 ENOG4105XJC Two component transcriptional regulator (Winged helix family AM488_06375 ENOG4105DHQ Histidine kinase AM488_06380 ENOG4105NF4 modulator of drug activity AM488_06385 ENOG4105VRH Antibiotic biosynthesis monooxygenase AM488_06390 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AM488_06395 ENOG4105IPS esterase AM488_06400 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AM488_06405 ENOG4108SX3 cytoplasmic protein AM488_06410 ENOG41087AY ADP-Ribose pyrophosphatase AM488_06420 ENOG4105F1G UPF0441 protein AM488_06425 ENOG4106032 Glutathionylspermidine synthase AM488_06430 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AM488_06440 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AM488_06445 ENOG4105W0Z cytoplasmic protein AM488_06455 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AM488_06460 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AM488_06465 ENOG4105I7R Adenylate cyclase AM488_06470 ENOG4106MWK domain protein AM488_06475 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AM488_06480 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AM488_06485 ENOG4107ZVW dihydroneopterin aldolase AM488_06490 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AM488_06500 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AM488_06520 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) AM488_06540 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AM488_06550 ENOG4105VCC 30S ribosomal protein S21 AM488_06555 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AM488_06560 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AM488_06565 ENOG4108VCA G U mismatch-specific DNA glycosylase AM488_06585 ENOG4108WQH regulatoR AM488_06590 ENOG4105BZU Histidine kinase AM488_06595 ENOG4108V08 YfdX protein AM488_06600 ENOG4108YK4 Acid-resistance membrane protein AM488_06605 ENOG4105XXV Acid-resistance protein AM488_06610 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AM488_06615 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit AM488_06620 ENOG4108ZFT Dehydratase small subunit AM488_06625 ENOG4105YCI dehydratase medium subunit AM488_06640 ENOG4105C0A alcohol dehydrogenase AM488_06680 ENOG4105CMT Dihydroxyacetone kinase AM488_06685 ENOG4108UTZ Dihydroxyacetone kinase AM488_06700 ENOG4105Q26 Siderophore-interacting protein AM488_06705 ENOG4105NTW Transcriptional regulator AM488_06715 ENOG4105C8Y Acetylornithine aminotransferase AM488_06720 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound AM488_06725 ENOG41061GT Aldolase AM488_06730 ENOG4105D4B ABC, transporter AM488_06735 ENOG4105F5R ABC transporter AM488_06740 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AM488_06745 ENOG4105C2J ABC transporter AM488_06750 ENOG4105DKT Transcriptional regulator AM488_06755 ENOG4107RYS Autoinducer-2 (AI-2) kinase AM488_06760 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AM488_06765 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AM488_06780 ENOG4108VKG metal-dependent hydrolase AM488_06785 ENOG4105EE0 oxidoreductase AM488_06790 ENOG4105DU1 integral membrane protein, terc AM488_06795 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) AM488_06800 ENOG4105P66 Membrane AM488_06805 ENOG4105CTX dehydratase AM488_06815 ENOG4105DPW Major facilitator superfamily MFS_1 AM488_06820 ENOG4107YCY Transcriptional regulator AM488_06825 ENOG4106W5V Membrane AM488_06830 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) AM488_06835 ENOG4105WAY exported protein AM488_06840 ENOG4105NE1 Conserved Protein AM488_06845 ENOG41090KG Inner membrane protein YqjE AM488_06850 ENOG4105YJD AM488_06855 ENOG4108VBZ doxx family AM488_06860 ENOG4105CHF Glutathione S-transferase AM488_06865 ENOG4105KAF membrAne AM488_06870 ENOG4105CWB LysR family transcriptional Regulator AM488_06875 ENOG4108CNN domain protein AM488_06895 ENOG4105BZW Glycerate kinase AM488_06900 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AM488_06905 ENOG4105CNV Aldolase AM488_06910 ENOG4105DJB Major Facilitator Superfamily AM488_06915 ENOG4105CTX dehydratase AM488_06920 ENOG4107UEK pfkb domain protein AM488_06925 ENOG4105MVE transcriptional regulator AM488_06930 ENOG4105D2N Aldolase AM488_06935 ENOG4105DE4 1-phosphofructokinase AM488_06940 ENOG4105DM4 PTS System AM488_06945 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein AM488_06950 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of AM488_06955 ENOG41082GB PTS system galactitol-specific transporter subunit IIA AM488_06960 ENOG41090UW PTS System AM488_06965 ENOG4105DT3 PTS system, galactitol-specific IIc component AM488_06970 ENOG4107WTH Galactitol-1-phosphate dehydrogenase AM488_06980 ENOG4107R3N Filamentation induced by cAMP protein fic AM488_06985 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AM488_06990 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) AM488_06995 ENOG41082RQ UPF0102 protein AM488_07005 ENOG4105W4M Transport-associated protein AM488_07010 ENOG4107S21 permease AM488_07015 ENOG4105K4T epimerase AM488_07020 ENOG4107R7Y intracellular protease Pfpi family AM488_07025 ENOG4108ZPB UPF0306 protein AM488_07030 ENOG41082IR Excinuclease ABC C subunit domain protein AM488_07035 ENOG4108YYD acetyltransferase AM488_07040 ENOG4105XPQ lipid carrier protein AM488_07045 ENOG4105CFP Peptidase U32 AM488_07050 ENOG4106RZ4 Peptidase U32 AM488_07055 ENOG4105DEN Luciferase family AM488_07060 ENOG4105CIC tryptophan-specific transport protein AM488_07065 ENOG4105C1J atp-dependent rna helicase AM488_07080 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AM488_07090 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AM488_07095 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AM488_07105 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AM488_07110 ENOG4105CHV Transcription elongation factor NusA AM488_07125 ENOG4105CDH Citrulline--aspartate ligase AM488_07130 ENOG4108PNB DNA-binding transcriptional regulator AM488_07135 ENOG4108UII YfaZ family AM488_07160 ENOG4105EEI dihydropteroate synthase AM488_07165 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AM488_07170 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AM488_07175 ENOG4105HBR Rna-binding protein AM488_07180 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AM488_07185 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase AM488_07190 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AM488_07195 ENOG4105QYV Membrane AM488_07210 ENOG4105EAH synthase AM488_07215 ENOG4105HVQ Regulatory factor of maltose metabolism AM488_07220 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AM488_07225 ENOG4105VFK BolA family AM488_07230 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane AM488_07235 ENOG4105E3I toluene tolerance AM488_07240 ENOG4107PE3 Mammalian cell entry related domain protein AM488_07245 ENOG4105CY3 ABC transporter, permease AM488_07250 ENOG4105DHJ ABC, transporter AM488_07260 ENOG4105FEU K -dependent Na -Ca exchanger AM488_07265 ENOG4105C2X Arabinose 5-phosphate isomerase AM488_07270 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase AM488_07275 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) AM488_07280 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA AM488_07285 ENOG4108IUZ ABC transporter AM488_07290 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AM488_07295 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA AM488_07300 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AM488_07310 ENOG41080Z8 PHOSPHOCARRIER protein AM488_07320 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain AM488_07325 ENOG4105BZU Histidine kinase AM488_07330 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) AM488_07335 ENOG4105CPQ Dehydrogenase AM488_07340 ENOG4108I5G Major Facilitator superfamily AM488_07345 ENOG4105N5T Radical SAM Protein AM488_07355 ENOG4105CBC glutamate synthase AM488_07360 ENOG4105BZ8 glutamate synthase AM488_07365 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) AM488_07370 ENOG4105KB2 stringent starvation protein b AM488_07375 ENOG4107MKT Stringent starvation protein a AM488_07385 ENOG4108UJD 30S ribosomal protein S9 AM488_07395 ENOG4105D6Z AFG1 family ATPase AM488_07400 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III AM488_07405 ENOG4105C0H protease AM488_07410 ENOG4105C0H protease AM488_07415 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AM488_07425 ENOG4105RID UPF0379 protein yhcN AM488_07430 ENOG4105RID UPF0379 protein yhcN AM488_07435 ENOG4105UNR (Barnase) inhibitor AM488_07440 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) AM488_07455 ENOG4105CR8 Transcriptional regulator AM488_07460 ENOG4105D1U peptidase U62 modulator of DNA gyrase AM488_07465 ENOG4105QD6 exported protein AM488_07470 ENOG4105C03 ribonuclease AM488_07480 ENOG4105VQ7 Rod shape-determining protein MreD AM488_07485 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AM488_07490 ENOG4105DFF Rod shape-determining protein mreb AM488_07500 ENOG41062P1 Diguanylate cyclase phosphodiesterase AM488_07510 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AM488_07515 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) AM488_07530 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AM488_07535 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AM488_07540 ENOG4105RG0 Membrane AM488_07545 ENOG4108IA2 Sodium pantothenate symporter AM488_07550 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AM488_07560 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AM488_07565 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AM488_07575 ENOG4105CAR Terminase, large subunit AM488_07665 ENOG4105XB7 anti-repressor protein AM488_07680 ENOG4105DFP Integrase AM488_07685 ENOG4108XG4 DNA-binding transcriptional regulator AM488_07690 ENOG4105C1P efflux transporter, rnd family, mfp subunit AM488_07695 ENOG4105BZS acriflavin resistance protein AM488_07700 ENOG4105XCM membrane LIPOPROTEIN AM488_07735 ENOG4108Z0R Transferase AM488_07740 ENOG4105SG3 Protein of unknown function (DUF1488) AM488_07745 ENOG4105E2X shikimate dehydrogenase AM488_07750 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AM488_07755 ENOG4108WI1 Dna topoisomerase AM488_07765 ENOG4105C79 DNA protecting protein DprA AM488_07770 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AM488_07775 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AM488_07780 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AM488_07785 ENOG4105C1A potassium transporter peripheral membrane AM488_07795 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system AM488_07800 ENOG4105W1Y Transcriptional regulator AM488_07805 ENOG4105VTS DnaJ-like, subfamily C AM488_07815 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AM488_07825 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AM488_07835 ENOG41067V7 50S ribosomal protein L36 AM488_07840 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AM488_07850 ENOG4105VPB 50S ribosomal protein L30 AM488_07855 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AM488_07860 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AM488_07865 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AM488_07870 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AM488_07885 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AM488_07890 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AM488_07895 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AM488_07905 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AM488_07910 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AM488_07920 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AM488_07955 ENOG4108UQY Iron-storage protein AM488_07960 ENOG4105W53 bacterioferritin-associated ferredoxin AM488_07970 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AM488_07975 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AM488_07980 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AM488_07990 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) AM488_07995 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) AM488_08000 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) AM488_08005 ENOG4105WWK YheO domain protein AM488_08010 ENOG4108V1T peptidylprolyl cis-trans isomerase AM488_08020 ENOG4108YZY peptidylprolyl cis-trans isomerase AM488_08025 ENOG4105VKU nucleicacid-binding protein AM488_08030 ENOG4105CKD glutathione-regulated potassium-efflux system protein AM488_08035 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AM488_08045 ENOG4105C5H ABC transporter AM488_08055 ENOG4105DNZ Alpha Beta Hydrolase AM488_08065 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) AM488_08070 ENOG4108UKZ OsmC family AM488_08085 ENOG410613R integral membrane protein, YccS YhfK family AM488_08090 ENOG4105C8Y Acetylornithine aminotransferase AM488_08100 ENOG4105MZU cell filamentation protein AM488_08105 ENOG4106195 uncharacterized protein yhfG AM488_08110 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AM488_08115 ENOG4106DTQ Protein TsgA homolog AM488_08120 ENOG4105DZC cytosine deaminase AM488_08125 ENOG4107QZF nitrite reductase NADPH large subunit AM488_08130 ENOG4105WZK nitrite reductase NADPH small subunit AM488_08135 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AM488_08140 ENOG4105C31 Tryptophanyl-tRNA synthetase AM488_08150 ENOG4105DJV ribulose-phosphate 3-epimerase AM488_08155 ENOG4105DFE Dna adenine methylase AM488_08160 ENOG4105EGB membrane protein DamX AM488_08165 ENOG4105D49 3-dehydroquinate synthase AM488_08170 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AM488_08180 ENOG4105E4G Type IV pilus AM488_08205 ENOG4108JQC penicillin-binding protein 1A AM488_08210 ENOG4107RK2 ADP-ribose diphosphatase NudE AM488_08215 ENOG4105DQY intracellular growth attenuator AM488_08220 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 AM488_08225 ENOG4105VEJ Heat shock protein AM488_08240 ENOG4105E0F Histidine kinase AM488_08245 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AM488_08250 ENOG4108RRZ Transcription elongation factor GreB AM488_08255 ENOG4105BZM domain protein AM488_08260 ENOG4105XFK Ferrous iron transport protein A AM488_08265 ENOG4105CE1 Ferrous iron transport protein b AM488_08270 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) AM488_08280 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AM488_08285 ENOG4105MJ2 Competence protein AM488_08295 ENOG4105C6Z Gluconate AM488_08300 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) AM488_08305 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AM488_08315 ENOG41061ZR Transcriptional regulator AM488_08320 ENOG4105E98 transcriptional regulator DeoR family AM488_08325 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) AM488_08330 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AM488_08335 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AM488_08350 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AM488_08355 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AM488_08360 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AM488_08365 ENOG4108IUM Glycogen debranching enzyme AM488_08370 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AM488_08375 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AM488_08385 ENOG4105C6Z Gluconate AM488_08390 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AM488_08395 ENOG4105DIQ Transcriptional regulator AM488_08400 ENOG4105C2I pirin domain protein AM488_08405 ENOG4105D9R oxidoreductase AM488_08415 ENOG4105WCN acetyltransferase AM488_08420 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AM488_08425 ENOG4105WC8 Conserved Protein AM488_08430 ENOG4107T6V glycerophosphoryl diester phosphodiesterase AM488_08445 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AM488_08450 ENOG4105BZ7 extracellular solute-binding protein family 1 AM488_08460 ENOG41060M8 Pfam:PhdYeFM AM488_08465 ENOG4108IV0 ABC, transporter AM488_08470 ENOG4105C0Z ABC transporter AM488_08475 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AM488_08480 ENOG4105C32 Amino acid ABC transporter (Permease) AM488_08485 ENOG4105CP9 extracellular ligand-binding receptor AM488_08495 ENOG4105U59 -acetyltransferase AM488_08500 ENOG4105CP9 extracellular ligand-binding receptor AM488_08510 ENOG4108JPW Aminotransferase AM488_08525 ENOG4105CRP Part of the ABC transporter FtsEX involved in AM488_08530 ENOG4105CAK Cell division ATP-binding protein ftsE AM488_08535 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AM488_08540 ENOG4106H78 methyltransferase AM488_08545 ENOG4105MG3 Membrane AM488_08555 ENOG4107FS9 Membrane AM488_08570 ENOG4105EX9 Membrane AM488_08575 ENOG4108W1V Lipoprotein AM488_08580 ENOG4105F9N Major Facilitator Superfamily AM488_08585 ENOG4105DSF transport protein AM488_08590 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) AM488_08595 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) AM488_08600 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AM488_08605 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AM488_08610 ENOG4105C3I Nad-dependent epimerase dehydratase AM488_08615 ENOG4105CKK Glycosyl transferase, family 2 AM488_08620 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AM488_08625 ENOG4105PY6 Phenolic acid decarboxylase AM488_08640 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AM488_08645 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AM488_08650 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM488_08660 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) AM488_08670 ENOG4105CJW magnesium transporter AM488_08675 ENOG4105CBX hi0933 family AM488_08680 ENOG4105CJ3 phosphate transporter AM488_08690 ENOG4108M6U Universal stress protein A AM488_08695 ENOG4105DUX Transporter AM488_08700 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) AM488_08705 ENOG4105DGW oligopeptidase A AM488_08710 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AM488_08715 ENOG4105D6S protein involved in catabolism of external DNA AM488_08720 ENOG4105DC8 reductase AM488_08730 ENOG4105C0A alcohol dehydrogenase AM488_08745 ENOG4105CHR reductase AM488_08750 ENOG4105CBN LysR family transcriptional regulator AM488_08755 ENOG4107H3J ribonuclease AM488_08760 ENOG4105CSH Transporter AM488_08765 ENOG41066T0 asmA family AM488_08780 ENOG4105CS0 peptidase AM488_08785 ENOG4105CK2 sodium dicarboxylate symporter AM488_08795 ENOG4105BZU Histidine kinase AM488_08800 ENOG4105EJG cellulose synthase AM488_08805 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) AM488_08810 ENOG4107EEX Cellulose synthase regulator protein AM488_08815 ENOG4107QZ7 Cellulose synthase catalytic subunit AM488_08820 ENOG4105UTS cellulose synthase operon protein YhjQ AM488_08825 ENOG410661M cytoplasmic protein AM488_08830 ENOG4105U74 cellulose biosynthesis protein BcsE AM488_08835 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT AM488_08840 ENOG4105D1V cellulose synthase operon protein YhjU AM488_08855 ENOG4105EJG cellulose synthase AM488_08860 ENOG4107EEX Cellulose synthase regulator protein AM488_08865 ENOG4107QZ7 Cellulose synthase catalytic subunit AM488_08885 ENOG4108JQ7 (ABC) transporter AM488_08890 ENOG4105C3U ABC transporter AM488_08895 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM488_08900 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AM488_08905 ENOG4105DEF Extracellular solute-binding protein, family 5 AM488_08940 ENOG4105DIJ Phosphoethanolamine transferase AM488_08945 ENOG4105FCD Major Facilitator AM488_08950 ENOG4105EAX Putative lipase AM488_08955 ENOG4108R3E Dna-3-methyladenine glycosylase i AM488_08960 ENOG4105HNP -acetyltransferase AM488_08965 ENOG4107QY8 reductase AM488_08970 ENOG4108ZG0 Ompa motb domain protein AM488_08975 ENOG4108M60 Transcriptional regulator AM488_08985 ENOG4105D7K pfkb domain protein AM488_08995 ENOG4105C5I Dehydrogenase AM488_09000 ENOG4106JH6 (LipO)protein AM488_09010 ENOG4105D2S major facilitator superfamily AM488_09015 ENOG4105MVF Transcriptional regulator AM488_09020 ENOG4105VEQ Cold shock protein AM488_09030 ENOG41060TC Hok gef cell toxic protein AM488_09035 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AM488_09040 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AM488_09055 ENOG4105MEV Acyl-transferase AM488_09060 ENOG4108Z12 YiaAB two helix domain-containing protein AM488_09065 ENOG410688U Inner membrane protein yiaB AM488_09070 ENOG4105CMG Carbohydrate kinase AM488_09075 ENOG4105C93 Xylose Isomerase AM488_09085 ENOG4105DFW ABC transporter AM488_09090 ENOG4105C2J ABC transporter AM488_09095 ENOG4107RNG ABC transporter AM488_09100 ENOG4105T16 Transcriptional regulator (AraC family) AM488_09105 ENOG4108UR8 BAX protein AM488_09115 ENOG4107T9C Alpha amylase catalytic region AM488_09120 ENOG4105JKW Valine--pyruvate aminotransferase AM488_09125 ENOG4108RC0 Electron transport protein AM488_09130 ENOG4105J4Q Transcriptional regulator AM488_09135 ENOG4105EM7 Selenocysteine-specific translation elongation factor AM488_09140 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) AM488_09145 ENOG4108U78 Glutathione S-transferase AM488_09150 ENOG4105EFX secretion protein, HlyD family AM488_09155 ENOG4105FP6 Protein of unknown function (DUF3302) AM488_09160 ENOG4105CTS PTS system mannitol-specific AM488_09165 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase AM488_09170 ENOG4105E61 Mannitol repressor protein AM488_09180 ENOG4108YYI Protein of unknown function (DUF2810) AM488_09185 ENOG4105DAA L-lactate AM488_09190 ENOG41073TP transcriptional regulator AM488_09195 ENOG4105DMF Dehydrogenase AM488_09200 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AM488_09205 ENOG4105D7W serine acetyltransferase AM488_09210 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AM488_09220 ENOG4105VW4 glutaredoxin 3 AM488_09225 ENOG4107YZP Rhodanese domain protein AM488_09235 ENOG41063SB peptidase AM488_09240 ENOG4105PXI polysaccharide deacetylase AM488_09245 ENOG4106WTF Glycosyl transferase, family 2 AM488_09250 ENOG4105CPQ Dehydrogenase AM488_09255 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AM488_09260 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) AM488_09265 ENOG4105XA0 heptosyltransferase ii AM488_09270 ENOG4105D16 lipopolysaccharide heptosyltransferase i AM488_09295 ENOG4105DKP glycosyl transferase, family 9 AM488_09305 ENOG4105CPK Glycosyl transferase (Group 1 AM488_09310 ENOG4105K64 Glycosyl transferase, family 2 AM488_09315 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AM488_09320 ENOG4106WTF Glycosyl transferase, family 2 AM488_09325 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AM488_09330 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AM488_09345 ENOG4105W5Q DNA repair protein (RadC AM488_09350 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AM488_09355 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AM488_09360 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AM488_09375 ENOG4107QWP ABC-2 type transporter AM488_09380 ENOG4105CJ1 ABC, transporter AM488_09400 ENOG4105DSJ YicC domain protein AM488_09405 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) AM488_09410 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AM488_09420 ENOG4105EN6 Membrane AM488_09425 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) AM488_09430 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AM488_09435 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AM488_09440 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AM488_09445 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase AM488_09450 ENOG4105CB5 ATP-dependent DNA helicase recG AM488_09455 ENOG4105CBT Fructose-1,6-bisphosphatase AM488_09460 ENOG4105DP0 ferredoxin-NADP reductase AM488_09465 ENOG4108VTS Membrane AM488_09470 ENOG4105EBK exported protein AM488_09475 ENOG4105CP7 Triose-phosphate isomerase AM488_09490 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AM488_09495 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) AM488_09500 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AM488_09505 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AM488_09510 ENOG4105D6U Sodium Glutamate Symporter AM488_09515 ENOG4105C2W permease AM488_09520 ENOG4105JV1 AsmA family AM488_09525 ENOG4105CI1 PTS System AM488_09530 ENOG4105F8D glycoside hydrolase family 4 AM488_09540 ENOG4105CJQ hydrolase, family 31 AM488_09545 ENOG4105CT4 transporter AM488_09560 ENOG4105NI3 Protein of unknown function (DUF3237) AM488_09580 ENOG4105DQ4 alcohol dehydrogenase AM488_09590 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein AM488_09605 ENOG4105D01 (LipO)protein AM488_09630 ENOG4105CR8 Transcriptional regulator AM488_09640 ENOG410630P Transcriptional regulator AM488_09655 ENOG4105C1P efflux transporter, rnd family, mfp subunit AM488_09660 ENOG4105BZS acriflavin resistance protein AM488_09665 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AM488_09670 ENOG4105C2C drug resistance transporter, Bcr CflA AM488_09675 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AM488_09680 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) AM488_09685 ENOG4108UZ3 Transporter AM488_09690 ENOG4105T8A Uncharacterized protein YicS AM488_09705 ENOG4105JSC dimethylmenaquinone methyltransferase AM488_09715 ENOG4107F9Y LysR family transcriptional regulator AM488_09725 ENOG4105D2S major facilitator superfamily AM488_09730 ENOG4105ETE Transcriptional regulator (LacI family AM488_09740 ENOG4105CK1 PTS System AM488_09745 ENOG4105VCP PTS System AM488_09750 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) AM488_09770 ENOG4108MP3 ABC transporter, permease AM488_09785 ENOG4106S9K Transcriptional regulator AM488_09795 ENOG4107STF Involved in phosphonate degradation (By similarity) AM488_09800 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AM488_09820 ENOG4108SAJ Protein of unknown function (DUF1198) AM488_09825 ENOG4105CXY transporter AM488_09830 ENOG4105CXY transporter AM488_09835 ENOG4105BZU Histidine kinase AM488_09840 ENOG4108KX4 response regulator AM488_09845 ENOG4105M71 acetolactate synthase 1 regulatory subunit AM488_09850 ENOG4105C7K acetolactate synthase AM488_09875 ENOG4105E5M Multidrug resistance protein D AM488_09880 ENOG4105W8I Transcriptional regulator AM488_09900 ENOG4105JP4 Inner membrane protein yidG AM488_09905 ENOG4105VG5 Membrane AM488_09910 ENOG4105F8D glycoside hydrolase family 4 AM488_09915 ENOG4105CI1 PTS System AM488_09920 ENOG4105FDP GntR family transcriptional regulator AM488_09925 ENOG4105D0C transport protein AM488_09930 ENOG4105F5P DNA-damage-inducible protein d AM488_09945 ENOG4105R2A (LipO)protein AM488_09950 ENOG4105D99 atp gtp-binding protein AM488_09955 ENOG4105DJB Major Facilitator Superfamily AM488_09960 ENOG4105CXK mandelate racemase muconate lactonizing AM488_09965 ENOG4108RTU Aldolase AM488_09970 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 AM488_09975 ENOG4105EMF GntR family transcriptional regulator AM488_09990 ENOG410667J hydrolase AM488_09995 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AM488_10000 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AM488_10005 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AM488_10030 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AM488_10035 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AM488_10045 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AM488_10055 ENOG4105C2C drug resistance transporter, Bcr CflA AM488_10065 ENOG4105E8Q phosphopantetheinyl transferase AM488_10070 ENOG4108YYH Nadph-dependent fmn reductase AM488_10075 ENOG4105C7N Xanthine uracil vitamin C permease AM488_10085 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 AM488_10090 ENOG4107VKM 6-phosphogluconolactonase AM488_10095 ENOG4105DYC esterase AM488_10100 ENOG4108P68 Outer membrane porin AM488_10115 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AM488_10120 ENOG4105E2Z phosphate ABC transporter (Permease AM488_10125 ENOG4105C8U phosphate abc transporter AM488_10130 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) AM488_10135 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AM488_10140 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AM488_10145 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AM488_10150 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AM488_10155 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AM488_10160 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AM488_10165 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AM488_10175 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AM488_10185 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation AM488_10190 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AM488_10195 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AM488_10200 ENOG4105QTB Flavodoxin AM488_10205 ENOG4108VVK transcriptional Regulator, AsnC AM488_10210 ENOG4105CU9 asparagine synthetase A AM488_10225 ENOG4105DFH Transport of potassium into the cell (By similarity) AM488_10235 ENOG4105C2J ABC transporter AM488_10240 ENOG4105CNN ABC, transporter AM488_10245 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AM488_10250 ENOG4108RVA ribokinase AM488_10255 ENOG4105ETE Transcriptional regulator (LacI family AM488_10260 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM488_10265 ENOG4107EJG GntR family transcriptional regulator AM488_10295 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b AM488_10300 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AM488_10305 ENOG4105PC1 Conserved Protein AM488_10310 ENOG4105E27 serine threonine protein kinase AM488_10320 ENOG4106HNH Acyl-transferase AM488_10330 ENOG4105C2M dna polymerase I AM488_10335 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AM488_10340 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) AM488_10350 ENOG4105D4P Coproporphyrinogen iii oxidase AM488_10355 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AM488_10360 ENOG4105CUX Signal transduction histidine kinase AM488_10365 ENOG4105C5F glutamine synthetase AM488_10380 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 AM488_10385 ENOG4107S2Z UPF0761 membrane protein AM488_10390 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AM488_10395 ENOG4105SUU thioesterase domain AM488_10405 ENOG41068KX affects formate dehydrogenase-N AM488_10420 ENOG4108MG3 formate dehydrogenase AM488_10425 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AM488_10440 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AM488_10450 ENOG4105CTQ phosphohexokinase AM488_10465 ENOG4105D2N Aldolase AM488_10510 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) AM488_10520 ENOG4105C0A alcohol dehydrogenase AM488_10525 ENOG4105CNN ABC, transporter AM488_10530 ENOG4105CNN ABC, transporter AM488_10535 ENOG4105C2J ABC transporter AM488_10540 ENOG4105D4B ABC, transporter AM488_10545 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) AM488_10550 ENOG4105DKG l-rhamnose isomerase AM488_10555 ENOG4105DET Rhamnulokinase AM488_10565 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) AM488_10570 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) AM488_10575 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) AM488_10580 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AM488_10585 ENOG4108RPX mosc domain containing protein AM488_10590 ENOG4105E0F Histidine kinase AM488_10595 ENOG4105E3W Two component transcriptional regulator (Winged helix family AM488_10600 ENOG4105FMW periplasmic AM488_10605 ENOG41076HS cation diffusion facilitator family transporter AM488_10620 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AM488_10635 ENOG41063M6 Cell Division Protein AM488_10640 ENOG4105ETE Transcriptional regulator (LacI family AM488_10645 ENOG4105C25 Primosomal protein n' AM488_10650 ENOG4105VFB Binds the 23S rRNA (By similarity) AM488_10655 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) AM488_10660 ENOG4105C28 cystathionine AM488_10665 ENOG4105CFH Aspartokinase AM488_10675 ENOG4105CGH 5'-nucleotidase AM488_10680 ENOG4108Z8I decarboxylase AM488_10685 ENOG4105CN8 Transcriptional regulator AM488_10690 ENOG4105SYT Methylenetetrahydrofolate reductase AM488_10695 ENOG4108Q5Y Membrane AM488_10700 ENOG4105DCT glycerol dehydrogenase AM488_10705 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AM488_10710 ENOG4106R3P AraC family transcriptional regulator AM488_10715 ENOG4108MEK Metal-binding protein YodA AM488_10730 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AM488_10735 ENOG4105CAS nag kinase AM488_10745 ENOG4105CH7 arginosuccinase AM488_10755 ENOG4105C5Q Transcriptional regulator AM488_10760 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) AM488_10765 ENOG4105EJ2 Transcriptional regulator AM488_10770 ENOG4108Y73 Membrane AM488_10775 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) AM488_10830 ENOG4108WFC UPF0438 protein yifE AM488_10835 ENOG4105C0P Mg chelatase subunit ChlI AM488_10850 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit AM488_10855 ENOG4105CM2 brancheD-chain amino acid aminotransferase AM488_10860 ENOG4105C01 Dihydroxy-acid dehydratase AM488_10865 ENOG4105C7B Threonine dehydratase AM488_10870 ENOG4105EMY transcriptional regulator AM488_10875 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AM488_10880 ENOG4105KQ5 peptidylprolyl cis-trans isomerase AM488_10885 ENOG4105KQ5 peptidylprolyl cis-trans isomerase AM488_10890 ENOG4105C4R Atp-dependent dna helicase AM488_10895 ENOG4108UQV Membrane AM488_10910 ENOG4105C9X ppx gppa phosphatase AM488_10920 ENOG4105C1J atp-dependent rna helicase AM488_10925 ENOG4105K63 Thioredoxin AM488_10940 ENOG4105ESV Glycosyl transferase, family 4 AM488_10945 ENOG4105SFE lipopolysaccharide biosynthesis protein AM488_10950 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AM488_10955 ENOG4108IJ1 Dehydrogenase AM488_10960 ENOG4105C1B dTDP-glucose 4-6-dehydratase AM488_10965 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AM488_10970 ENOG4108WJ1 acetyltransferase AM488_10975 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AM488_10980 ENOG4105EGZ biosynthesis protein AM488_10985 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) AM488_10990 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) AM488_10995 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family AM488_11000 ENOG4105C85 amino acid AM488_11025 ENOG410601J HemY protein AM488_11030 ENOG4105ECF c-methyltransferase AM488_11035 ENOG41076E6 Uroporphyrinogen-III Synthase AM488_11040 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AM488_11045 ENOG4107T0K Adenylate cyclase AM488_11050 ENOG4105XQ6 frataxin-like protein AM488_11055 ENOG4105S7Z (LipO)protein AM488_11065 ENOG4105CT0 Protein of unknown function, DUF484 AM488_11070 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AM488_11075 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant AM488_11080 ENOG4105C4R Atp-dependent dna helicase AM488_11090 ENOG4107QUT magnesium and cobalt transport protein CorA AM488_11095 ENOG4105FR1 rard protein AM488_11100 ENOG4108VUY thioesterase Superfamily protein AM488_11105 ENOG4105HDD phospholipase AM488_11110 ENOG4105C9U ATP-dependent DNA helicase RecQ AM488_11130 ENOG4108EUD Lysophospholipase AM488_11135 ENOG4105DQF Hydrolase AM488_11140 ENOG4105EMK carboxylate amino acid amine transporter AM488_11145 ENOG4105DZ2 Transcriptional regulator AM488_11150 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AM488_11155 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) AM488_11160 ENOG4107SXA Phosphorylase AM488_11165 ENOG4105CGY Dna recombination protein AM488_11170 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AM488_11175 ENOG4105JC1 sterol-binding domain protein AM488_11180 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AM488_11185 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AM488_11195 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AM488_11205 ENOG4105MDZ Transcriptional activator rfaH AM488_11210 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AM488_11215 ENOG4107QK7 reductase AM488_11220 ENOG4105CHU acetyl-coa acetyltransferase AM488_11225 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) AM488_11235 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) AM488_11240 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AM488_11245 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AM488_11250 ENOG4108RR8 protoporphyrinogen oxidase AM488_11280 ENOG4105D4A Cell wall formation (By similarity) AM488_11285 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AM488_11290 ENOG4105CS9 pantothenic acid kinase AM488_11315 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AM488_11325 ENOG4105PM1 preprotein translocase subunit SecE AM488_11330 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AM488_11335 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AM488_11340 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AM488_11360 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AM488_11365 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AM488_11370 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AM488_11375 ENOG4105VCP PTS System AM488_11385 ENOG4106TD9 Diguanylate cyclase AM488_11395 ENOG4105D41 biosynthesis protein thiH AM488_11400 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AM488_11405 ENOG4105WHD thiamine biosynthesis protein ThiS AM488_11410 ENOG4105D06 uba thif-type nad fad binding protein AM488_11415 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AM488_11420 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AM488_11425 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) AM488_11430 ENOG4105E09 nadh pyrophosphatase AM488_11435 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AM488_11440 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) AM488_11445 ENOG4105R2J Conserved Protein AM488_11450 ENOG4105K70 DNA-binding protein AM488_11455 ENOG4108T8B Protein of unknown function (DUF1481) AM488_11460 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism AM488_11465 ENOG4105BZU Histidine kinase AM488_11475 ENOG4105C12 Phosphoribosylglycinamide synthetase AM488_11480 ENOG4105DC1 bifunctional purine biosynthesis protein purh AM488_11520 ENOG4105K5X acetyltransferase AM488_11525 ENOG4105CVG Homoserine O-transsuccinylase AM488_11530 ENOG4107QP3 malate synthase g AM488_11535 ENOG4108I9X Isocitrate lyase AM488_11540 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) AM488_11545 ENOG41069M3 Transcriptional regulator AM488_11550 ENOG4105C3R Methionine synthase AM488_11570 ENOG4105F9E Shikimate 5-dehydrogenase AM488_11575 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein AM488_11580 ENOG4105F3R pts system mannose fructose sorbose family iid AM488_11585 ENOG4105ETZ PTS System AM488_11590 ENOG4105KPI PTS system sorbose subfamily IIB component AM488_11595 ENOG4108XCU pts system AM488_11600 ENOG4105CHR reductase AM488_11605 ENOG4105DKT Transcriptional regulator AM488_11610 ENOG4105FE9 pseudouridine synthase AM488_11615 ENOG4108ZR5 Conserved Protein AM488_11620 ENOG4105C09 Bile acid AM488_11625 ENOG4105CFH Aspartokinase AM488_11640 ENOG4107QP8 phosphohexose isomerase AM488_11645 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AM488_11655 ENOG4105KME endoribonuclease L-psp AM488_11670 ENOG4105CEM UPF0597 protein AM488_11675 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AM488_11680 ENOG4105EG2 ABC transporter, permease AM488_11685 ENOG4105D56 permease protein AM488_11690 ENOG4107FKK extracellular solute-binding protein family 1 AM488_11705 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) AM488_11710 ENOG4107W52 maltose operon periplasmic protein AM488_11715 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) AM488_11720 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) AM488_11725 ENOG4105E55 glycerol-3-phosphate acyltransferase AM488_11730 ENOG41080IJ Diacylglycerol kinase AM488_11735 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AM488_11740 ENOG4107R73 Mate efflux family protein AM488_11745 ENOG4105VDW Csbd family AM488_11750 ENOG4105MYN Zinc uptake regulation protein AM488_11760 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AM488_11765 ENOG4105P4Z Phage shock protein G AM488_11770 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AM488_11775 ENOG4105CDU Replicative dna helicase AM488_11780 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AM488_11785 ENOG4105CGF Aromatic amino acid aminotransferase AM488_11795 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AM488_11800 ENOG4105MSB protein, conserved in bacteria AM488_11805 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AM488_11815 ENOG4108UUM single-stranded DNA-binding protein AM488_11820 ENOG4105E4C Lytic transglycosylase catalytic AM488_11825 ENOG4107RNH Outer membrane receptor FepA AM488_11830 ENOG4108DMH HTH_ARAC AM488_11850 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AM488_11865 ENOG4105ECY inositol monophosphatase AM488_11870 ENOG4105ETE Transcriptional regulator (LacI family AM488_11875 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AM488_11900 ENOG4105PMV Membrane AM488_11910 ENOG4108M8H domain protein AM488_11915 ENOG4108W3Q Transcriptional regulator AM488_11920 ENOG4108Z4X TRANSCRIPTIONal AM488_11925 ENOG4108K3A Glutathione S-transferase AM488_11930 ENOG4105C7N Xanthine uracil vitamin C permease AM488_11935 ENOG4105EEQ Na H antiporter AM488_11940 ENOG4105CMU LysR family (Transcriptional regulator AM488_11950 ENOG41067MG lrgb family AM488_11955 ENOG4105MX3 Fimbrial AM488_11960 ENOG4108VCD Chaperone AM488_11965 ENOG4105CW0 outer membrane usher protein AM488_11985 ENOG41062QD Membrane AM488_11995 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AM488_12005 ENOG4105CK2 sodium dicarboxylate symporter AM488_12010 ENOG41082ND Uncharacterized protein yjcO AM488_12040 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AM488_12045 ENOG4105CNN ABC, transporter AM488_12050 ENOG4105C2J ABC transporter AM488_12055 ENOG4105BZU Histidine kinase AM488_12065 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein AM488_12070 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) AM488_12075 ENOG4105FD8 phosphonate metabolism protein PhnM AM488_12080 ENOG4105HRV phosphonate c-p lyase system protein phnl AM488_12085 ENOG4105ENV phosphonate C-P lyase system protein PhnK AM488_12090 ENOG4105FT8 Phosphonate metabolism AM488_12095 ENOG4105EKV Phosphonate metabolism protein AM488_12100 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH AM488_12105 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG AM488_12110 ENOG4107RJJ Transcriptional regulator AM488_12115 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase AM488_12120 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AM488_12130 ENOG4105CSH Transporter AM488_12135 ENOG4108K2B transcriptional regulator AM488_12145 ENOG4105F8D glycoside hydrolase family 4 AM488_12150 ENOG4105CT4 transporter AM488_12175 ENOG4105DVC DnaJ domain protein AM488_12180 ENOG4108ZCF integral membrane protein AM488_12200 ENOG4105CND Glycosyl transferase, family 2 AM488_12205 ENOG4107BJW polysaccharide deacetylase AM488_12210 ENOG4108TUY outer membrane protein PgaA AM488_12240 ENOG4108SIC Transcriptional regulator AM488_12245 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AM488_12255 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AM488_12260 ENOG4108IJ0 Aspartate ammonia-lyase AM488_12270 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 AM488_12275 ENOG4105DVH amino acid AM488_12285 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AM488_12290 ENOG4108ZVF (LipO)protein AM488_12300 ENOG4108JJA ABC, transporter AM488_12305 ENOG4108MBX Secretion Protein AM488_12325 ENOG4105CW0 outer membrane usher protein AM488_12345 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AM488_12360 ENOG4106BSU Entericidin B AM488_12365 ENOG4105KPY Small multidrug resistance protein AM488_12385 ENOG4105E33 succinate dehydrogenase AM488_12390 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AM488_12395 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AM488_12400 ENOG4107SC7 Inner membrane transporter yjeM AM488_12405 ENOG4105EGS Mechanosensitive ion channel AM488_12410 ENOG4105DJ4 phosphatidylserine decarboxylase AM488_12415 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AM488_12425 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AM488_12430 ENOG4106TNF Periplasmic binding protein AM488_12455 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AM488_12460 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AM488_12465 ENOG4105K8N protein family UPF0079, ATPase AM488_12470 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AM488_12475 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AM488_12485 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AM488_12490 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AM488_12495 ENOG4107QJR hflk protein AM488_12500 ENOG4105EPW hflc protein AM488_12515 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AM488_12525 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AM488_12530 ENOG4105C2N RNA methyltransferase TrmH family group 3 AM488_12535 ENOG4105CSU acyl-Coa dehydrogenase AM488_12540 ENOG4105S17 UPF0379 protein yjfN AM488_12545 ENOG4105WSB biofilm stress and motility protein A AM488_12550 ENOG4108MXZ Esterase AM488_12565 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC AM488_12570 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport AM488_12575 ENOG4106ETB IIa component AM488_12600 ENOG4105KIT UPF0379 protein yjfY AM488_12605 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AM488_12610 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) AM488_12615 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AM488_12620 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AM488_12625 ENOG4105FHY Opacity-associated protein A AM488_12630 ENOG4108V1T peptidylprolyl cis-trans isomerase AM488_12640 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AM488_12645 ENOG4105DXC membrane AM488_12655 ENOG4105ECR NmrA family AM488_12660 ENOG4105KVH Transcriptional regulator AM488_12665 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic AM488_12670 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase AM488_12675 ENOG4108UUE Transcriptional regulator AM488_12680 ENOG41061GZ Protein of unknown function (DUF1107) AM488_12690 ENOG4105C37 (CBS) domain AM488_12700 ENOG4105CFU surface antigen AM488_12705 ENOG4105MA0 exported protein AM488_12710 ENOG4108ZHD aig2 family AM488_12725 ENOG4105F0N pyrophosphate phospho-hydrolase AM488_12730 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator AM488_12735 ENOG4105C2J ABC transporter AM488_12740 ENOG4107R9N ABC transporter AM488_12745 ENOG41062B0 ABC transporter, permease AM488_12750 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AM488_12755 ENOG4105DFU Cell wall formation (By similarity) AM488_12770 ENOG4105N42 UPF0307 protein AM488_12775 ENOG4105CMS peptidase U62, modulator of DNA gyrase AM488_12780 ENOG4108XVM Cytochrome b(562) AM488_12810 ENOG41069H0 dihydroorotase EC 3.5.2.3 AM488_12825 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AM488_12830 ENOG4105EMD TRANSCRIPTIONal AM488_12840 ENOG4105K4U addiction module toxin, RelE StbE family AM488_12845 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) AM488_12850 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AM488_12865 ENOG4105F8D glycoside hydrolase family 4 AM488_12870 ENOG4105CK1 PTS System AM488_12875 ENOG4105CG3 alpha amylase, catalytic region AM488_12880 ENOG4105C5Y PTS System AM488_12885 ENOG4105D4X repressor AM488_12900 ENOG4105KME endoribonuclease L-psp AM488_12905 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) AM488_12910 ENOG4105CXT aspartate transcarbamylase AM488_12925 ENOG4105XEP YhcH YjgK YiaL family protein AM488_12930 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine AM488_12935 ENOG4108KPW sugar kinase AM488_12940 ENOG4105CI2 imidazolone-5-propionate hydrolase AM488_12945 ENOG4105CSX c4-dicarboxylate anaerobic carrier AM488_12950 ENOG4105FDP GntR family transcriptional regulator AM488_12960 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) AM488_12965 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase AM488_12970 ENOG4108MJ3 acetyltransferase AM488_12975 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AM488_12980 ENOG4105MYG DNA polymerase iii, chi subunit AM488_12985 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AM488_12995 ENOG4108M8S permease YjgP YjgQ family protein AM488_13000 ENOG4108K5H permease YjgP YjgQ family protein AM488_13005 ENOG4105D7A ATP-binding protein AM488_13015 ENOG4105C26 Dehydrogenase AM488_13020 ENOG4105DH8 myo-inositol catabolism AM488_13060 ENOG4105CHC glucokinase (EC 2.7.1.2) AM488_13065 ENOG4105D7K pfkb domain protein AM488_13070 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) AM488_13080 ENOG4105F0H myo-inositol catabolism protein AM488_13085 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AM488_13090 ENOG4108IJG ABC transporter substrate-binding protein AM488_13095 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AM488_13100 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AM488_13105 ENOG4105DRS transport system, permease AM488_13115 ENOG4105DQ4 alcohol dehydrogenase AM488_13120 ENOG4105CHH sulfate transporter AM488_13125 ENOG41077A9 carbonic anhydrase AM488_13165 ENOG4105ZTC transcriptional activator, Ogr delta AM488_13255 ENOG4105DSG hydrolase family 43 AM488_13260 ENOG4105CT4 transporter AM488_13265 ENOG4105C93 Xylose Isomerase AM488_13270 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) AM488_13275 ENOG4107SEY Conserved Protein AM488_13295 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AM488_13310 ENOG4107FW0 short-chain dehydrogenase reductase AM488_13320 ENOG4108XDN Transcriptional regulator AM488_13325 ENOG4105QNF Outer membrane lipoprotein AM488_13335 ENOG4108IJF Heavy metal efflux pump, CzcA AM488_13340 ENOG4105EP1 Efflux transporter rnd family, mfp subunit AM488_13345 ENOG410624V efflux system protein AM488_13350 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AM488_13360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AM488_13365 ENOG4105GR3 Histidine kinase AM488_13380 ENOG4105EZE Cupin 4 family protein AM488_13420 ENOG4105CMI transporter AM488_13425 ENOG4105CJ1 ABC, transporter AM488_13430 ENOG4105D0S secretion protein (HlyD AM488_13440 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AM488_13445 ENOG4105C2J ABC transporter AM488_13450 ENOG4105CNN ABC, transporter AM488_13455 ENOG4105CNN ABC, transporter AM488_13460 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AM488_13465 ENOG41064T2 transcriptional regulator, lysR family AM488_13475 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AM488_13480 ENOG4106DIZ Domain of unknown function (DUF1127) AM488_13490 ENOG4105EFX secretion protein, HlyD family AM488_13505 ENOG4105CIZ coA-substrate-specific enzyme activase AM488_13510 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase AM488_13520 ENOG41083G8 Multidrug resistance protein MdtM AM488_13525 ENOG4106BRA Membrane AM488_13535 ENOG4106AXJ AraC family transcriptional regulator AM488_13545 ENOG4105DNE Transposase AM488_13550 ENOG4105C26 Dehydrogenase AM488_13560 ENOG4105CKI cobalamin synthesis protein AM488_13565 ENOG4105VCD cytoplasmic protein AM488_13570 ENOG4105D22 carbon starvation protein AM488_13585 ENOG4107UWN reductase AM488_13590 ENOG4105EFA 4-hydroxyphenylacetate AM488_13605 ENOG4105CNV Aldolase AM488_13620 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase AM488_13625 ENOG4105C26 Dehydrogenase AM488_13635 ENOG4105ERH Fumarylacetoacetate hydrolase AM488_13645 ENOG4108V8F Transcriptional regulator, MarR family AM488_13660 ENOG4105DG4 malate L-lactate dehydrogenase AM488_13690 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 AM488_13695 ENOG4108RTU Aldolase AM488_13700 ENOG4106KNT transcriptional regulator AM488_13705 ENOG4105XYF acetyltransferase AM488_13715 ENOG4108I5G Major Facilitator superfamily AM488_13720 ENOG410617M Transcriptional regulator AM488_13725 ENOG4105CPQ Dehydrogenase AM488_13730 ENOG4107QZW Altronate oxidoreductase AM488_13735 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AM488_13745 ENOG4105KPI PTS system sorbose subfamily IIB component AM488_13750 ENOG4105ETZ PTS System AM488_13755 ENOG4105F3R pts system mannose fructose sorbose family iid AM488_13770 ENOG4105DNE Transposase AM488_13780 ENOG4105RI1 glycoprotein receptor AM488_13785 ENOG4106CVF DNA replication protein AM488_13790 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) AM488_13795 ENOG4107XM3 UPF0442 protein AM488_13800 ENOG4105DWK Membrane AM488_13810 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase AM488_13820 ENOG4108N8T regulatoR AM488_13825 ENOG4108T94 DNA-binding transcriptional activator BglJ AM488_13830 ENOG4108UIN ybak prolyl-trna synthetase associated region AM488_13835 ENOG4105CK1 PTS System AM488_13840 ENOG4108819 ferric iron reductase AM488_13845 ENOG4106TD9 Diguanylate cyclase AM488_13850 ENOG4105YBH Protein of unknown function (DUF1435) AM488_13870 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AM488_13875 ENOG4108WPU DNA polymerase III subunit psi AM488_13880 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AM488_13885 ENOG4105PAD Hydrolase AM488_13890 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AM488_13895 ENOG4105K3G Periplasmic Protein AM488_13905 ENOG4108NRW Phospholipase, patatin family AM488_13910 ENOG4105EYA deoxyribonuclease AM488_13915 ENOG4105D9N nucleoside AM488_13925 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AM488_13940 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) AM488_13945 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) AM488_13955 ENOG4105EAC phosphoserine phosphatase AM488_13960 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AM488_13965 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase AM488_13970 ENOG4105C5H ABC transporter AM488_13980 ENOG4107SC1 transglycosylase AM488_13985 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) AM488_13990 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AM488_13995 ENOG4105CVJ phosphoglycerate mutase AM488_14000 ENOG4105UEI Transcriptional Regulator AraC Family AM488_14005 ENOG4108RH0 Crea protein AM488_14010 ENOG4105E3W Two component transcriptional regulator (Winged helix family AM488_14015 ENOG4105EB3 Histidine kinase AM488_14020 ENOG4105CT7 inner membrane cred family protein AM488_14025 ENOG41065U4 response regulator AM488_14030 ENOG410759A AM488_14040 ENOG4106FVC RNA methyltransferase AM488_14050 ENOG4105CFH Aspartokinase AM488_14055 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AM488_14060 ENOG4105D98 threonine synthase AM488_14070 ENOG4105D1Q UPF0246 protein AM488_14075 ENOG4105BZG amino acid carrier protein AM488_14085 ENOG4108RIR Molybdenum cofactor biosynthesis protein AM488_14090 ENOG4105CSH Transporter AM488_14095 ENOG4106HK8 GPR1 FUN34 yaaH family protein AM488_14100 ENOG4108QUJ UPF0174 protein YaaW AM488_14105 ENOG4108WTA UPF0412 protein YaaI AM488_14110 ENOG4105CFG Acts as a chaperone (By similarity) AM488_14115 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AM488_14120 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AM488_14125 ENOG41063Z6 transcriptional regulator, lysR family AM488_14140 ENOG4105DTN riboflavin biosynthesis protein ribF AM488_14150 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AM488_14155 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase AM488_14165 ENOG4105DU0 nucleoside hydrolase AM488_14175 ENOG4105EXG Transcriptional regulator AM488_14180 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AM488_14185 ENOG4106YYS transcriptional regulatory protein AM488_14190 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AM488_14195 ENOG4105D9Q decarboxylase (Beta subunit) AM488_14200 ENOG4107QSA Oxaloacetate decarboxylase AM488_14210 ENOG4105D2K citrate carrier protein AM488_14215 ENOG4105DUA (citrate (pro-3S)-lyase ligase AM488_14220 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) AM488_14225 ENOG4105CI0 Citrate lyase AM488_14230 ENOG4105CHY citrate lyase, alpha AM488_14235 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase AM488_14240 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AM488_14250 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AM488_14255 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AM488_14260 ENOG4105M5B (LipO)protein AM488_14270 ENOG4105CKD glutathione-regulated potassium-efflux system protein AM488_14280 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AM488_14290 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AM488_14300 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AM488_14305 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AM488_14315 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AM488_14320 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) AM488_14325 ENOG4106YYS transcriptional regulatory protein AM488_14330 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AM488_14335 ENOG4105D2K citrate carrier protein AM488_14350 ENOG4105D3G Pseudouridine synthase AM488_14355 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) AM488_14360 ENOG4105CQ2 DNA polymerase AM488_14365 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase AM488_14370 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) AM488_14375 ENOG4105EF1 ribulokinase AM488_14385 ENOG4108KF1 Membrane AM488_14395 ENOG4106SMU thiamine transporter membrane protein AM488_14400 ENOG4105DP9 ABC transporter AM488_14415 ENOG4105S8Q sugar efflux transporter AM488_14420 ENOG4105DJB Major Facilitator Superfamily AM488_14425 ENOG4105C5Q Transcriptional regulator AM488_14430 ENOG4105FF2 Type I DHQase AM488_14435 ENOG4105EMV Major Facilitator AM488_14450 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AM488_14455 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AM488_14465 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AM488_14475 ENOG41064T2 transcriptional regulator, lysR family AM488_14485 ENOG4105C7K acetolactate synthase AM488_14490 ENOG4108ZP8 Acetolactate synthase small subunit AM488_14495 ENOG4107B7Y DNA-binding transcriptional regulator FruR AM488_14510 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AM488_14515 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AM488_14520 ENOG4105CJN penicillin-binding protein AM488_14525 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AM488_14530 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AM488_14535 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AM488_14545 ENOG4105CNI cell division protein FtsW AM488_14550 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AM488_14555 ENOG4105DFU Cell wall formation (By similarity) AM488_14560 ENOG4105CPF Cell wall formation (By similarity) AM488_14565 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AM488_14570 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AM488_14575 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AM488_14580 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AM488_14585 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) AM488_14590 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AM488_14595 ENOG4105M6F mutator MutT protein AM488_14600 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) AM488_14605 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) AM488_14610 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AM488_14615 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AM488_14620 ENOG4105D7Q type ii secretion system AM488_14625 ENOG4107QHF type ii secretion system protein e AM488_14630 ENOG4108ZUW Major pilin subunit AM488_14635 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AM488_14640 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AM488_14645 ENOG4106A72 regulatory protein AmpE AM488_14650 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) AM488_14655 ENOG4105CT4 transporter AM488_14660 ENOG4105C85 amino acid AM488_14665 ENOG41073TP transcriptional regulator AM488_14670 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AM488_14675 ENOG4107QSN dihydrolipoamide acetyltransferase AM488_14680 ENOG4107QN2 dihydrolipoyl dehydrogenase AM488_14695 ENOG4108NST exported protein AM488_14710 ENOG4107QIJ Aconitate hydratase 2 AM488_14715 ENOG4108ZIG UPF0231 protein AM488_14720 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AM488_14725 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AM488_14750 ENOG4108ZRK uncharacterized protein yacC AM488_14755 ENOG4105E3B Multicopper oxidase AM488_14760 ENOG4105DZG Dehydrogenase AM488_14765 ENOG4108UGV hypoxanthine phosphoribosyltransferase AM488_14770 ENOG41077A9 carbonic anhydrase AM488_14775 ENOG4105DA5 (ABC) transporter AM488_14780 ENOG4105E3A (ABC) transporter AM488_14785 ENOG4108YTN IIa component AM488_14790 ENOG4107BJW polysaccharide deacetylase AM488_14795 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AM488_14800 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AM488_14805 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AM488_14810 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AM488_14815 ENOG4105DJ0 Poly(A) Polymerase AM488_14820 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AM488_14825 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AM488_14830 ENOG4105PW4 Sugar fermentation stimulation protein homolog AM488_14835 ENOG4107XID 2'-5' rna ligase AM488_14840 ENOG4105CQ7 ATP-dependent helicase AM488_14930 ENOG4105BZ4 penicillin-binding protein AM488_14935 ENOG4105E0K tonB-dependent siderophore receptor AM488_14940 ENOG4105E0A ABC, transporter AM488_14945 ENOG4105J76 Periplasmic binding protein AM488_14950 ENOG4105S6R Iron-hydroxamate transporter permease subunit AM488_14955 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AM488_14960 ENOG4105CMQ Chloride channel AM488_14965 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AM488_14970 ENOG4105EN6 Membrane AM488_14975 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AM488_14980 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AM488_14985 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AM488_14990 ENOG4105C0H protease AM488_14995 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR AM488_15000 ENOG4108T8E UPF0325 protein AM488_15010 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AM488_15015 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AM488_15020 ENOG4105CE9 30S ribosomal protein S2 AM488_15030 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AM488_15040 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AM488_15055 ENOG4105KNE Phosphatidate cytidylyltransferase AM488_15060 ENOG4105DZP Membrane-associated zinc metalloprotease AM488_15070 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) AM488_15085 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AM488_15090 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AM488_15095 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AM488_15100 ENOG4105C0B DNA polymerase III (alpha subunit) AM488_15105 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AM488_15110 ENOG4105CXN decarboxylase AM488_15115 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AM488_15120 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AM488_15125 ENOG4105M1T rho-binding antiterminator AM488_15130 ENOG4105W1I UPF0253 protein AM488_15135 ENOG4108VWS Yaeq family AM488_15140 ENOG4108YZN class I peptide chain release factor AM488_15145 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion AM488_15150 ENOG4108UY0 (LipO)protein AM488_15155 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AM488_15160 ENOG4108R96 Methyltransferase, YaeB family AM488_15165 ENOG4108R8X outer membrane lipoprotein AM488_15170 ENOG4105D01 (LipO)protein AM488_15175 ENOG4108UMI ABC transporter, permease AM488_15180 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AM488_15185 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AM488_15225 ENOG4105CV8 reductase AM488_15230 ENOG4105HEI LysR family (Transcriptional regulator AM488_15235 ENOG4105F27 Major Facilitator AM488_15245 ENOG4105F2W methyltransferase AM488_15250 ENOG4105E9H Lytic Murein transglycosylase AM488_15255 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AM488_15260 ENOG4105D1A Methyltransferase AM488_15265 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AM488_15270 ENOG4107RZZ dna polymerase iii epsilon subunit AM488_15285 ENOG41090KR LysR family transcriptional Regulator AM488_15290 ENOG4108VP3 Lysine exporter protein (LysE YggA) AM488_15295 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AM488_15300 ENOG4107QPN acyl-Coa dehydrogenase AM488_15305 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AM488_15310 ENOG4105E7A Glutamine amidotransferase AM488_15315 ENOG4105F7V ErfK ybiS ycfS ynhG family protein AM488_15325 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AM488_15330 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AM488_15335 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AM488_15340 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AM488_15345 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AM488_15350 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) AM488_15365 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AM488_15370 ENOG4108HYG acetyltransferase AM488_15375 ENOG4105CIN aminoacyl-histidine dipeptidase AM488_15385 ENOG4105V1F Fermentation respiration switch protein AM488_15390 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) AM488_15395 ENOG4108PVQ transcriptional regulator AM488_15400 ENOG4105C85 amino acid AM488_15405 ENOG4108JPW Aminotransferase AM488_15410 ENOG4105C26 Dehydrogenase AM488_15415 ENOG4105D5U fad dependent oxidoreductase AM488_15430 ENOG4105YCT UPF0386 protein AM488_15435 ENOG4105DTA methyltransferase AM488_15440 ENOG4108TGY Glutathione S-transferase AM488_15445 ENOG4105DT3 PTS system, galactitol-specific IIc component AM488_15450 ENOG4108JQ1 Dehydrogenase AM488_15455 ENOG4105CHR reductase AM488_15460 ENOG4105CMG Carbohydrate kinase AM488_15470 ENOG41061GT Aldolase AM488_15495 ENOG4105CPP Dehydrogenase, E1 component AM488_15500 ENOG4107R0V Pyruvate dehydrogenase AM488_15545 ENOG4105ZTC transcriptional activator, Ogr delta AM488_15560 ENOG4107QJE Chromosome Partitioning Protein AM488_15565 ENOG4105DFP Integrase AM488_15575 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AM488_15580 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AM488_15585 ENOG4105FCK Membrane AM488_15590 ENOG4108QBX (LipO)protein AM488_15625 ENOG4105S7S phosphonate abc transporter AM488_15635 ENOG4105EHI Phosphonate ABC transporter, periplasmic AM488_15645 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon AM488_15650 ENOG4108GWT fimbrillin MatB AM488_15655 ENOG4108NN8 Fimbrial protein AM488_15660 ENOG4108N3D putative enzyme AM488_15665 ENOG4106PYX Receptor AM488_15675 ENOG4105DRP amino acid AbC transporter AM488_15680 ENOG4105E5Q amino acid AbC transporter AM488_15685 ENOG4105CDA abc transporter atp-binding protein AM488_15690 ENOG4105CT1 (ABC) transporter AM488_15700 ENOG4108IV0 ABC, transporter AM488_15705 ENOG4105C0Z ABC transporter AM488_15710 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AM488_15715 ENOG4105C32 Amino acid ABC transporter (Permease) AM488_15725 ENOG4107FQ9 ethanolamine ammonia-lyase AM488_15730 ENOG4105CPD ethanolamine ammonia-lyase AM488_15735 ENOG4105C85 amino acid AM488_15740 ENOG4108IQI permease AM488_15745 ENOG4107QK5 Homocysteine s-methyltransferase AM488_15750 ENOG4106FTQ Taurine ABC transporter, periplasmic AM488_15755 ENOG4108ETV ABC transporter AM488_15760 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AM488_15765 ENOG4105E2B Taurine dioxygenase AM488_15775 ENOG4105D52 delta-aminolevulinic acid dehydratase AM488_15780 ENOG4107R6D beta-lactam binding protein AmpH AM488_15785 ENOG4108RWI nicotinamidase AM488_15790 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 AM488_15795 ENOG4107QS8 (LipO)protein AM488_15800 ENOG4105FR5 inner membrane protein YaiY AM488_15805 ENOG4105UNH Membrane AM488_15810 ENOG4105CPF Cell wall formation (By similarity) AM488_15830 ENOG4105G6Z alkaline phosphatase AM488_15835 ENOG4105VIF phosphate starvation-inducible protein AM488_15840 ENOG4105II7 pyrroline-5-carboxylate reductase AM488_15845 ENOG4108UPT UPF0178 protein AM488_15850 ENOG4105G4C Periplasmic ligand-binding sensor protein AM488_15855 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AM488_15860 ENOG4105SS3 AM488_15865 ENOG4105HBA AroM protein AM488_15880 ENOG4105DKQ ROK family AM488_15885 ENOG4105EYH Exonuclease AM488_15890 ENOG4107RH8 nuclease SbcCD subunit D AM488_15895 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AM488_15900 ENOG4105BZU Histidine kinase AM488_15905 ENOG4105CWM branched-chain amino acid transport system II carrier protein AM488_15910 ENOG4105C85 amino acid AM488_15915 ENOG4107R28 alpha amylase, catalytic region AM488_15920 ENOG4105EQ1 Transcriptional regulator AM488_15925 ENOG4105CHJ isochorismatase hydrolase AM488_15935 ENOG4105CI2 imidazolone-5-propionate hydrolase AM488_15945 ENOG4108MGF sugar kinase AM488_15960 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia AM488_15965 ENOG4105D3R alkyl hydroperoxide reductase AM488_15970 ENOG4108ZYK Acyl carrier protein phosphodiesterase AM488_15985 ENOG4105VIE preprotein translocase, subunit YajC AM488_15990 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AM488_15995 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AM488_16010 ENOG4105DRB nucleoside-specific channel-forming protein AM488_16015 ENOG4108KIC (LipO)protein AM488_16025 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AM488_16030 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AM488_16035 ENOG4107YIM Involved in the transcription termination process (By similarity) AM488_16040 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AM488_16045 ENOG4108ZAI phosphatidylglycerophosphatase a AM488_16050 ENOG4105CPC Aldo Keto reductase AM488_16055 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AM488_16060 ENOG4105CTB Polyprenyl synthetase AM488_16070 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) AM488_16080 ENOG4107S0N DJ-1 family AM488_16085 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AM488_16095 ENOG4107RDB Major Facilitator AM488_16100 ENOG4105CIB oxidoreductase Domain protein AM488_16105 ENOG4105D2S major facilitator superfamily AM488_16115 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein AM488_16125 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein AM488_16130 ENOG4105E2X shikimate dehydrogenase AM488_16135 ENOG4107HP6 Transcriptional regulator AM488_16145 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AM488_16150 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) AM488_16155 ENOG4105CCU oxidase (Subunit III) AM488_16160 ENOG4105BZ9 Cytochrome C oxidase, subunit I AM488_16165 ENOG4105E2S oxidase) subunit II AM488_16170 ENOG4105EYM Major Facilitator superfamily AM488_16175 ENOG4105IEY (LipO)protein AM488_16180 ENOG4105M85 Bola protein AM488_16195 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AM488_16205 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AM488_16210 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AM488_16215 ENOG4105K70 DNA-binding protein AM488_16220 ENOG4105EIN peptidylprolyl cis-trans isomerase AM488_16225 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein AM488_16230 ENOG4108TGP Thioesterase superfamily protein AM488_16235 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AM488_16240 ENOG4108NFA extracellular solute-binding protein AM488_16245 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) AM488_16255 ENOG4108XM1 transcriptional regulator AsnC family AM488_16260 ENOG4105BZ1 (ABC) transporter AM488_16265 ENOG4105BZ1 (ABC) transporter AM488_16270 ENOG4108YZA Nitrogen regulatory protein pii AM488_16275 ENOG4105BZU Histidine kinase AM488_16280 ENOG4105C29 acyl-CoA thioesterase AM488_16285 ENOG4108MNP Glycoprotein polysaccharide metabolism AM488_16290 ENOG41080UX Methyltransferase AM488_16320 ENOG4108VW9 Membrane AM488_16325 ENOG41061MD high-affinity nickel-transporter AM488_16330 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter AM488_16335 ENOG41066DG (EAL) domain protein AM488_16345 ENOG4107FKK extracellular solute-binding protein family 1 AM488_16355 ENOG4105EG2 ABC transporter, permease AM488_16365 ENOG4105C4C beta-galactosidase AM488_16370 ENOG4105CI1 PTS System AM488_16375 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) AM488_16380 ENOG4105ETE Transcriptional regulator (LacI family AM488_16405 ENOG4105GSJ Inner membrane protein ylaC AM488_16410 ENOG4108UW5 maltose o-acetyltransferase AM488_16420 ENOG4108UKR Biofilm formation regulator YbaJ AM488_16425 ENOG4105BZS acriflavin resistance protein AM488_16430 ENOG4105C1P efflux transporter, rnd family, mfp subunit AM488_16435 ENOG4108IG5 Transcriptional regulator AM488_16440 ENOG4105EGS Mechanosensitive ion channel AM488_16445 ENOG4105DNE Transposase AM488_16450 ENOG4106428 Protein of unknown function (DUF2496) AM488_16455 ENOG4108URS primosomal replication protein n'' AM488_16460 ENOG4105WD1 Membrane AM488_16470 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AM488_16475 ENOG4107QMP dna polymerase iii subunits gamma and tau AM488_16485 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AM488_16490 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AM488_16505 ENOG4107RE1 Inosine-guanosine kinase AM488_16510 ENOG4105CKD glutathione-regulated potassium-efflux system protein AM488_16515 ENOG4105EU0 Major facilitator Superfamily AM488_16520 ENOG4105CGH 5'-nucleotidase AM488_16525 ENOG4108Z66 YbaK ebsC protein AM488_16530 ENOG4105MBR gumn family AM488_16535 ENOG4105C59 p-type ATPase AM488_16540 ENOG4108Z6Z Transcriptional regulator AM488_16545 ENOG4105G5H Membrane AM488_16550 ENOG4107QX8 SPFH domain, Band 7 family protein AM488_16555 ENOG41083J0 (ABC) transporter AM488_16560 ENOG4105C4B ABC transporter, permease AM488_16570 ENOG4107QR8 Thioredoxin AM488_16575 ENOG4105E1F short-chain dehydrogenase reductase AM488_16580 ENOG4108UJV acyl-CoA thioesterase i AM488_16585 ENOG4108I0Y (ABC) transporter AM488_16590 ENOG4105CV6 ABC transporter, permease AM488_16605 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AM488_16610 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AM488_16625 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) AM488_16630 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AM488_16640 ENOG4105WQ3 Rna-binding protein AM488_16685 ENOG4105BZN citrate synthase AM488_16700 ENOG4105X0I Fimbrial AM488_16705 ENOG4105GQR Chaperone AM488_16710 ENOG4105CW0 outer membrane usher protein AM488_16725 ENOG4105D1S lipid A biosynthesis AM488_16735 ENOG4108M3R transcriptional activator CadC AM488_16740 ENOG4105D5Q Arginine ornithine antiporter AM488_16745 ENOG4105CXN decarboxylase AM488_16750 ENOG4105DUX Transporter AM488_16755 ENOG4105CRK lysyL-tRNA synthetase AM488_16795 ENOG4105C2J ABC transporter AM488_16800 ENOG4108HWV )-transporter AM488_16810 ENOG4105WBN Transcriptional regulator (LacI family AM488_16815 ENOG4108HKT sucrose-6-phosphate hydrolase AM488_16820 ENOG4105C5Y PTS System AM488_16825 ENOG4108M0B Sucrose porin AM488_16830 ENOG4105D7K pfkb domain protein AM488_16840 ENOG4105KK7 inner membrane protein YiaW AM488_16845 ENOG4105EFX secretion protein, HlyD family AM488_16850 ENOG4105E0A ABC, transporter AM488_16855 ENOG4105EHG Permease protein AM488_16875 ENOG4105CH2 amidohydrolase AM488_16880 ENOG4105E89 ABC transporter AM488_16885 ENOG4105CPC Aldo Keto reductase AM488_16905 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) AM488_16915 ENOG4108UAJ Transcriptional regulator AM488_16925 ENOG4105DGU Histone deacetylase AM488_16935 ENOG4105CUB amino acid AM488_16945 ENOG4105CJP fad dependent oxidoreductase AM488_16950 ENOG4105C26 Dehydrogenase AM488_16955 ENOG4108NS2 receptor AM488_16965 ENOG4105C85 amino acid AM488_16970 ENOG4105EAA nucleoside AM488_16980 ENOG4105CK5 oxidoreductase AM488_16990 ENOG4105ISV protein with bipartite regulator domain AM488_17000 ENOG4106PYX Receptor AM488_17005 ENOG4108N3D putative enzyme AM488_17015 ENOG4108GWT fimbrillin MatB AM488_17035 ENOG4105CUY Mechanosensitive ion channel AM488_17060 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AM488_17065 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine AM488_17070 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AM488_17075 ENOG4105F3R pts system mannose fructose sorbose family iid AM488_17085 ENOG4108IQ3 PTS system AM488_17095 ENOG4108RCM Nitroreductase AM488_17100 ENOG4105MSB protein, conserved in bacteria AM488_17115 ENOG4105HFT AraC family transcriptional regulator AM488_17120 ENOG4105WQ6 Membrane AM488_17150 ENOG4108T58 Mg2 transport protein CorA AM488_17155 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) AM488_17160 ENOG4105T38 integral membrane protein AM488_17165 ENOG4105CHM Aminotransferase AM488_17175 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AM488_17180 ENOG4105DRP amino acid AbC transporter AM488_17185 ENOG4105GBT ABC transporter AM488_17195 ENOG4105EMU Dehydrogenase AM488_17200 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AM488_17205 ENOG4108JQ7 (ABC) transporter AM488_17210 ENOG4105C3U ABC transporter AM488_17215 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM488_17220 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AM488_17225 ENOG4105DEF Extracellular solute-binding protein, family 5 AM488_17235 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) AM488_17255 ENOG4105C94 Transporter AM488_17260 ENOG4108WN0 inhibitor of vertebrate lysozyme AM488_17265 ENOG4105CUY Mechanosensitive ion channel AM488_17270 ENOG410810E transcriptional regulator, lysR family AM488_17280 ENOG4108R85 Short chain dehydrogenase AM488_17290 ENOG4105CNN ABC, transporter AM488_17295 ENOG4105C2J ABC transporter AM488_17305 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AM488_17310 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AM488_17315 ENOG4105DKT Transcriptional regulator AM488_17325 ENOG4108HHA Transketolase AM488_17330 ENOG4108IUS Transketolase AM488_17335 ENOG4108TSE Transferase AM488_17340 ENOG4107RNH Outer membrane receptor FepA AM488_17345 ENOG4105E93 esterase AM488_17350 ENOG41085A6 mbth domain-containing protein AM488_17355 ENOG4105C0W non-ribosomal peptide synthetase AM488_17360 ENOG4105E0A ABC, transporter AM488_17365 ENOG4105TVJ transport system, permease AM488_17370 ENOG4105DQ5 transport system permease protein AM488_17375 ENOG4105E8G Major facilitator Superfamily AM488_17380 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein AM488_17385 ENOG4105E4F Isochorismate synthase AM488_17390 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AM488_17395 ENOG4105WQI isochorismatase AM488_17400 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AM488_17405 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) AM488_17410 ENOG4105D22 carbon starvation protein AM488_17415 ENOG4105VCD cytoplasmic protein AM488_17430 ENOG4105F6U Short-chain dehydrogenase reductase Sdr AM488_17435 ENOG4107SCQ Iron-containing alcohol dehydrogenase AM488_17440 ENOG4105C2J ABC transporter AM488_17445 ENOG4105CNN ABC, transporter AM488_17460 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AM488_17465 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AM488_17470 ENOG4105D6F Phosphatase AM488_17475 ENOG4105CXY transporter AM488_17480 ENOG4105ECY inositol monophosphatase AM488_17485 ENOG4105ETE Transcriptional regulator (LacI family AM488_17490 ENOG4105DZC cytosine deaminase AM488_17500 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin AM488_17505 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AM488_17515 ENOG4108M3J Dehydrogenase AM488_17525 ENOG4105CNN ABC, transporter AM488_17535 ENOG4105C2J ABC transporter AM488_17550 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AM488_17555 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) AM488_17560 ENOG4105CHM Aminotransferase AM488_17565 ENOG4105GTN ParB Domain Protein Nuclease AM488_17570 ENOG4105BZV Phosphoadenosine phosphosulfate reductase AM488_17575 ENOG4105DQS Transcriptional regulator AM488_17580 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase AM488_17585 ENOG4105D3R alkyl hydroperoxide reductase AM488_17590 ENOG4108JU3 Alkyl hydroperoxide reductase AM488_17595 ENOG4108U51 Universal stress protein AM488_17600 ENOG4105NXH GreA GreB family elongation factor AM488_17605 ENOG4105KTS ribonuclease AM488_17610 ENOG4105CEE C4-dicarboxylate transporter AM488_17620 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) AM488_17625 ENOG4105VEQ Cold shock protein AM488_17635 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AM488_17640 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) AM488_17650 ENOG41064T2 transcriptional regulator, lysR family AM488_17655 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AM488_17665 ENOG4105DZ1 carboxypeptidase AM488_17670 ENOG4105K6T rare lipoprotein A AM488_17675 ENOG4105CNI cell division protein FtsW AM488_17680 ENOG4105CJN penicillin-binding protein AM488_17690 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AM488_17700 ENOG4108TGR phosphatase AM488_17705 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AM488_17710 ENOG4105DJF DNA polymerase III, delta' subunit AM488_17720 ENOG4105C8T Leucyl-tRNA synthetase AM488_17725 ENOG4107PAI alpha helical protein AM488_17740 ENOG4105CDA abc transporter atp-binding protein AM488_17745 ENOG4105DRP amino acid AbC transporter AM488_17750 ENOG4105EAD ABC transporter AM488_17755 ENOG4107RP9 extracellular solute-binding protein, family 3 AM488_17760 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AM488_17765 ENOG4108JU5 Magnesium and cobalt efflux protein AM488_17775 ENOG4105C9A Phoh family AM488_17780 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AM488_17785 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AM488_17830 ENOG4105CAQ asparagine synthetase AM488_17835 ENOG4105D4U had-superfamily hydrolase, subfamily iia AM488_17840 ENOG4105E2R ROK family AM488_17845 ENOG4105CE4 GlcNAc 6-P deacetylase AM488_17850 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AM488_17860 ENOG4105CI1 PTS System AM488_17865 ENOG4105CX6 glutaminyL-tRNA synthetase AM488_17875 ENOG4105J5J Outer membrane porin AM488_17880 ENOG4105GX6 (LipO)protein AM488_17890 ENOG41090R7 Ferric uptake AM488_17895 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) AM488_17900 ENOG4105NNH LexA regulated protein AM488_17905 ENOG4105EV9 Alpha Beta Hydrolase AM488_17910 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) AM488_17915 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 AM488_17925 ENOG4105EEX Two component transcriptional regulator (Winged helix family AM488_17930 ENOG4105C08 Histidine kinase AM488_17935 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) AM488_17940 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AM488_17945 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AM488_17955 ENOG4105XIQ Protein of unknown function (DUF2517) AM488_17960 ENOG4105CVP deoxyribo-dipyrimidine photolyase AM488_17965 ENOG4105DUX Transporter AM488_17970 ENOG4107QNR UPF0135 protein AM488_17975 ENOG4105P4J Allophanate hydrolase, subunit 1 AM488_17980 ENOG4107R7A Allophanate hydrolase subunit 2 AM488_17985 ENOG4105E7W lamb ycsf family protein AM488_18005 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) AM488_18010 ENOG4105BZN citrate synthase AM488_18025 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AM488_18030 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein AM488_18035 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AM488_18040 ENOG4105E33 succinate dehydrogenase AM488_18045 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AM488_18050 ENOG4105C7S Dehydrogenase AM488_18065 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AM488_18075 ENOG4105C4M (Ubiquinol oxidase) subunit I AM488_18080 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AM488_18090 ENOG4105KJB cyd operon protein YbgE AM488_18095 ENOG4107YD3 Thioesterase AM488_18100 ENOG4105E02 MotA TolQ exbB proton channel AM488_18105 ENOG4105M8F Biopolymer transport protein exbD tolR AM488_18110 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA AM488_18120 ENOG4105KCK Peptidoglycan-associated lipoprotein AM488_18125 ENOG4105UFD tol-pal system protein YbgF AM488_18170 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AM488_18175 ENOG4106Z1T Nicotinamide Mononucleotide Transporter AM488_18180 ENOG4105PGM cation diffusion facilitator family transporter AM488_18185 ENOG4105JND homeobox protein AM488_18190 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AM488_18200 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) AM488_18205 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AM488_18210 ENOG4105F0Z galactose-1-phosphate uridylyltransferase AM488_18215 ENOG4105CMR udp-glucose 4-epimerase AM488_18220 ENOG4105DKW ABC transporter AM488_18225 ENOG4105F4R Transcriptional regulator mode AM488_18230 ENOG410680R Protein of unknown function (DUF2592) AM488_18235 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AM488_18240 ENOG4105E0C molybdate abc transporter AM488_18245 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AM488_18250 ENOG4108K4B hydrolase AM488_18255 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AM488_18270 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component AM488_18275 ENOG4105BZU Histidine kinase AM488_18280 ENOG4108XDN Transcriptional regulator AM488_18310 ENOG4105NBR Pectinesterase AM488_18315 ENOG4105CI2 imidazolone-5-propionate hydrolase AM488_18320 ENOG41088SP formiminoglutamate hydrolase AM488_18330 ENOG4105CGP Urocanate hydratase AM488_18335 ENOG4105C84 Histidine ammonia-lyase AM488_18340 ENOG4105C85 amino acid AM488_18345 ENOG4108V1U phospholipid-binding protein AM488_18350 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AM488_18355 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AM488_18360 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AM488_18365 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AM488_18375 ENOG4108IV0 ABC, transporter AM488_18390 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AM488_18400 ENOG4105ECM Sensor protein basS pmrB AM488_18405 ENOG4105XJC Two component transcriptional regulator (Winged helix family AM488_18410 ENOG4105DIJ Phosphoethanolamine transferase AM488_18415 ENOG4105CHW UPF0052 protein AM488_18425 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AM488_18430 ENOG4108RIR Molybdenum cofactor biosynthesis protein AM488_18435 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AM488_18440 ENOG4105M00 molybdopterin converting factor, subunit 1 AM488_18445 ENOG4108ZAF Molybdopterin AM488_18450 ENOG4105HFZ Membrane AM488_18465 ENOG4107UXM Membrane AM488_18470 ENOG4105DZQ phospholipase D Transphosphatidylase AM488_18475 ENOG4105X23 Endonuclease Exonuclease phosphatase AM488_18480 ENOG4105I9U inner membrane protein ybhQ AM488_18490 ENOG4107QWP ABC-2 type transporter AM488_18495 ENOG4107QWP ABC-2 type transporter AM488_18500 ENOG4105CJ1 ABC, transporter AM488_18505 ENOG4105D0S secretion protein (HlyD AM488_18510 ENOG4107MVR Transcriptional regulator AM488_18515 ENOG4108PZW LysR family Transcriptional regulator AM488_18520 ENOG4105DJB Major Facilitator Superfamily AM488_18540 ENOG4105C1J atp-dependent rna helicase AM488_18545 ENOG4105DVT helicase AM488_18550 ENOG4108MTB glycosyl transferase family AM488_18555 ENOG4105VR4 UPF0379 protein ybiJ AM488_18560 ENOG4105KSC Transcriptional regulator, TraR DksA family AM488_18570 ENOG4105EW6 flavin reductase domain protein, FMN-binding AM488_18575 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) AM488_18580 ENOG4105D8X mechanosensitive ion channel AM488_18585 ENOG4105CDA abc transporter atp-binding protein AM488_18590 ENOG4105E5Q amino acid AbC transporter AM488_18595 ENOG4107R0W ABC transporter AM488_18610 ENOG4108T1M outer membrane protein x AM488_18615 ENOG4108I6E Sulfatase AM488_18625 ENOG4105KST dependent repressor AM488_18630 ENOG4105F4P )-transporter AM488_18635 ENOG4105CS2 ec 3.2.1.21 AM488_18640 ENOG4108TZY GntR Family Transcriptional Regulator AM488_18645 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AM488_18650 ENOG4105M2Z protein tyrosine serine phosphatase AM488_18655 ENOG4105C5H ABC transporter AM488_18670 ENOG4105DPW Major facilitator superfamily MFS_1 AM488_18675 ENOG4105ETE Transcriptional regulator (LacI family AM488_18680 ENOG41072TH Protein of unknown function (DUF1479) AM488_18685 ENOG4108HCJ Hydrolase AM488_18690 ENOG4105C6N Formate acetyltransferase AM488_18695 ENOG4105F1A Pyruvate formate-lyase AM488_18700 ENOG4105D06 uba thif-type nad fad binding protein AM488_18705 ENOG4105CVM Molybdenum cofactor synthesis domain protein AM488_18710 ENOG4105D44 asparaginase AM488_18715 ENOG4108JQ6 ABC transporter AM488_18720 ENOG4105DEF Extracellular solute-binding protein, family 5 AM488_18725 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AM488_18730 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM488_18740 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) AM488_18745 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) AM488_18750 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway AM488_18755 ENOG4105D8V Glucose sorbosone dehydrogenase AM488_18760 ENOG4108TGY Glutathione S-transferase AM488_18765 ENOG4105DZ1 carboxypeptidase AM488_18770 ENOG4107FB0 transcriptional regulator DeoR family AM488_18775 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AM488_18785 ENOG4107QF7 multi-drug AM488_18790 ENOG4108HCJ Hydrolase AM488_18795 ENOG4106UW1 Major Facilitator superfamily AM488_18800 ENOG4108RFG Tetr family transcriptional regulator AM488_18805 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AM488_18815 ENOG4105EKQ RNA-directed DNA polymerase AM488_18830 ENOG4105MEH AM488_18855 ENOG4105KSC Transcriptional regulator, TraR DksA family AM488_18860 ENOG4105DFE Dna adenine methylase AM488_18865 ENOG4105VZ1 Replication Protein AM488_18890 ENOG4105ED4 portal protein AM488_19035 ENOG4105ZTC transcriptional activator, Ogr delta AM488_19040 ENOG4105D0C transport protein AM488_19045 ENOG4105GWF inner membrane protein YbjM AM488_19050 ENOG41090BQ Glutaredoxin AM488_19055 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress AM488_19070 ENOG4108RMJ sensory transduction regulator AM488_19075 ENOG4107RUE extracellular solute-binding protein family 1 AM488_19080 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AM488_19085 ENOG4105F38 ABC transporter, permease AM488_19090 ENOG4105D38 putrescine abc transporter AM488_19095 ENOG4105RBQ inner membrane protein ybjO AM488_19100 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) AM488_19105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AM488_19110 ENOG4105BZU Histidine kinase AM488_19115 ENOG4106TNF Periplasmic binding protein AM488_19120 ENOG4105DMR ABC, transporter AM488_19125 ENOG4105GBT ABC transporter AM488_19130 ENOG4106PMH Extracellular solute-binding protein family 3 AM488_19135 ENOG4105E5Z arginine transporter ATP-binding subunit AM488_19140 ENOG41064MM (LipO)protein AM488_19155 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AM488_19160 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AM488_19165 ENOG4105CGD Nad-dependent epimerase dehydratase AM488_19170 ENOG4105C5W Aldolase AM488_19175 ENOG4105C7K acetolactate synthase AM488_19190 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AM488_19200 ENOG4105DWU Membrane AM488_19205 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AM488_19210 ENOG4105CPB ATP-dependent endonuclease of the OLD family AM488_19215 ENOG4105DJY efflux transporter, rnd family, mfp subunit AM488_19230 ENOG4105VEQ Cold shock protein AM488_19240 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AM488_19245 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AM488_19250 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AM488_19255 ENOG4108JJ8 (ABC) transporter AM488_19260 ENOG4108JJ9 ABC, transporter AM488_19265 ENOG4105C3M thioredoxin reductase AM488_19270 ENOG4105EW9 transcriptional regulator AsnC family AM488_19275 ENOG4105CNU cell division protein FtsK AM488_19280 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) AM488_19285 ENOG4105D1H recombination factor protein RarA AM488_19290 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AM488_19295 ENOG4107QY8 reductase AM488_19300 ENOG4105QAX Iron-sulfur AM488_19305 ENOG4107KGK dmso reductase anchor subunit AM488_19315 ENOG4108ISG Major Facilitator AM488_19320 ENOG4105F1A Pyruvate formate-lyase AM488_19325 ENOG4105C6N Formate acetyltransferase AM488_19330 ENOG4105TMB Formate nitrite transporter AM488_19335 ENOG4105DDY UPF0142 protein ycaO AM488_19340 ENOG4107VMU Membrane AM488_19345 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AM488_19350 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AM488_19355 ENOG4105CAT Cytidine monophosphate kinase AM488_19360 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AM488_19365 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AM488_19370 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 AM488_19375 ENOG4105BZ1 (ABC) transporter AM488_19380 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AM488_19385 ENOG4105T0Z Conserved Protein AM488_19390 ENOG4105W49 UPF0434 protein AM488_19395 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AM488_19400 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups AM488_19405 ENOG4107S90 membrAne AM488_19410 ENOG4106371 Methyltransferase AM488_19415 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) AM488_19420 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) AM488_19425 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) AM488_19430 ENOG4105DIT ErfK YbiS YcfS YnhG family protein AM488_19440 ENOG4105EAQ (twin-arginine translocation) pathway signal AM488_19445 ENOG4105C5X domain protein AM488_19450 ENOG4105CGF Aromatic amino acid aminotransferase AM488_19455 ENOG4105ZIT Porin Gram-negative type AM488_19470 ENOG4105C5S asparaginyl-tRNA synthetase AM488_19480 ENOG4107RCH Diaminopropionate ammonia-lyase AM488_19485 ENOG4105C44 Serine transporter AM488_19490 ENOG4105CE7 Amidase, hydantoinase carbamoylase family AM488_19495 ENOG4105CH2 amidohydrolase AM488_19500 ENOG4107RH7 Nicotinate phosphoribosyltransferase AM488_19510 ENOG4105CD8 aminopeptidase N AM488_19520 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AM488_19525 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AM488_19530 ENOG4105GVF (ABC) transporter AM488_19535 ENOG4108UZX fmn reductase AM488_19545 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) AM488_19550 ENOG4105QVC MOSC domain-containing protein AM488_19555 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AM488_19560 ENOG4105C5H ABC transporter AM488_19565 ENOG4105F1S paraquat-inducible protein a AM488_19570 ENOG4105DY2 Paraquat-inducible protein b AM488_19575 ENOG4108Q2G (LipO)protein AM488_19585 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) AM488_19590 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) AM488_19595 ENOG4105DAN ATP-dependent protease AM488_19600 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) AM488_19605 ENOG4105UYK outer membrane protein a AM488_19610 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) AM488_19620 ENOG4108RZ1 DNA transformation protein AM488_19625 ENOG4105EM2 membrane AM488_19630 ENOG410901E Membrane AM488_19635 ENOG41088T4 Helicase IV AM488_19645 ENOG4105K4P CoA-binding domain protein AM488_19655 ENOG4105DR4 Methyltransferase AM488_19660 ENOG4108V1U phospholipid-binding protein AM488_19665 ENOG4108UQN AraC family transcriptional regulator AM488_19670 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AM488_19680 ENOG4108MN8 Membrane AM488_19685 ENOG4107QSI ABC, transporter AM488_19695 ENOG4105BZU Histidine kinase AM488_19700 ENOG4105BZU Histidine kinase AM488_19710 ENOG4105E3J oxidoreductase AM488_19715 ENOG4105C26 Dehydrogenase AM488_19720 ENOG4105DVW rieske (2Fe-2S) AM488_19725 ENOG4105C94 Transporter AM488_19735 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AM488_19740 ENOG4105EJC lysr family transcriptional regulator AM488_19745 ENOG4105CJP fad dependent oxidoreductase AM488_19750 ENOG4105C26 Dehydrogenase AM488_19755 ENOG4107VRI Transcriptional regulator AM488_19760 ENOG4108Z86 Glutamine amidotransferase AM488_19765 ENOG4105CFQ glutamine synthetase AM488_19775 ENOG4105CUB amino acid AM488_19790 ENOG4105CHR reductase AM488_19795 ENOG4107YPT transcriptional regulator AM488_19800 ENOG4105D6F Phosphatase AM488_19805 ENOG4105XH3 AM488_19815 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 AM488_19825 ENOG4105C2W permease AM488_19830 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) AM488_19835 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) AM488_19840 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AM488_19845 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) AM488_19850 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AM488_19855 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) AM488_19860 ENOG4108R86 Transcriptional regulator AM488_19870 ENOG4105C26 Dehydrogenase AM488_19880 ENOG4105CK7 Sodium proline symporter AM488_19890 ENOG4105D9N nucleoside AM488_19895 ENOG4105EKT )-iron permease AM488_19900 ENOG410650H (LipO)protein AM488_19905 ENOG4105DBE peroxidase AM488_19910 ENOG4105D5M phosphate starvation-inducible protein AM488_19930 ENOG4105CHJ isochorismatase hydrolase AM488_19935 ENOG4105EUB pirin domain protein AM488_19940 ENOG4105HEI LysR family (Transcriptional regulator AM488_19965 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AM488_19975 ENOG4107XHZ cytoplasmic chaperone TorD family protein AM488_19980 ENOG4108UQ5 membrane protein YcdZ AM488_19995 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) AM488_20010 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) AM488_20015 ENOG4105NAC (LipO)protein AM488_20020 ENOG4108W47 Acidic protein msyB AM488_20035 ENOG4105D1S lipid A biosynthesis AM488_20045 ENOG4106974 biofilm formation AM488_20055 ENOG4105PVA Biofilm formation regulatory protein BssS AM488_20065 ENOG4105MEA DNA damage-inducible protein i AM488_20070 ENOG4105EKE dihydroorotase AM488_20075 ENOG4105F3T (LipO)protein AM488_20080 ENOG4105EV4 Multidrug resistance protein mdtH AM488_20085 ENOG4105D9U N-acetyltransferase AM488_20090 ENOG4108YXG UPF0502 protein AM488_20095 ENOG4105EP9 oxidoreductase AM488_20100 ENOG4105CJR Integral membrane protein (MviN AM488_20105 ENOG4105EQ0 Major Facilitator superfamily AM488_20110 ENOG4105CR8 Transcriptional regulator AM488_20115 ENOG4107QQB Ribonuclease E AM488_20120 ENOG41071G1 Uncharacterized protein YceQ AM488_20125 ENOG4105EI2 Pseudouridine synthase AM488_20130 ENOG4108UHJ MAF-like protein AM488_20135 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein AM488_20145 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AM488_20150 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AM488_20155 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AM488_20160 ENOG4105CHR reductase AM488_20165 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AM488_20170 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AM488_20175 ENOG4105YAZ 4-amino-4-deoxychorismate lyase AM488_20180 ENOG4105HHA aminodeoxychorismate lyase AM488_20185 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AM488_20190 ENOG4107QRG dna polymerase iii AM488_20195 ENOG4105F8V Hydrolase, tatD family AM488_20200 ENOG4105CI1 PTS System AM488_20205 ENOG4105K59 histidine triad (HIT) protein AM488_20210 ENOG41090DQ Lipoprotein AM488_20215 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) AM488_20230 ENOG4105D0Y UPF0227 protein AM488_20235 ENOG4105CEP NADH dehydrogenase AM488_20240 ENOG4107MBR 17 kDa surface antigen AM488_20250 ENOG4108IND Tetr family transcriptional regulator AM488_20255 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction AM488_20260 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AM488_20265 ENOG4108JA2 transcriptioN-repair coupling factor AM488_20270 ENOG4105D60 lipoprotein releasing system transmembrane protein AM488_20275 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AM488_20280 ENOG4105D60 lipoprotein releasing system transmembrane protein AM488_20285 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) AM488_20290 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AM488_20300 ENOG4105CEY Amp-dependent synthetase and ligase AM488_20310 ENOG4107RUE extracellular solute-binding protein family 1 AM488_20315 ENOG4105D38 putrescine abc transporter AM488_20320 ENOG4105F38 ABC transporter, permease AM488_20335 ENOG4105EZE Cupin 4 family protein AM488_20340 ENOG4105IFJ Histidine kinase AM488_20360 ENOG4107QTF adenylosuccinate lyase AM488_20370 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AM488_20385 ENOG4108HMX isocitrate dehydrogenase (NADP) AM488_20390 ENOG4108ZHR arsR family transcriptional regulator AM488_20405 ENOG4105XDF Protein of unknown function (DUF1272) AM488_20410 ENOG4105E2A Dehydrogenase AM488_20420 ENOG4108Z9Z response to DNA damage stimulus AM488_20425 ENOG4108N8X transition metal ion binding AM488_20430 ENOG4105WEF catalase AM488_20435 ENOG4105C4M (Ubiquinol oxidase) subunit I AM488_20440 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AM488_20465 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AM488_20470 ENOG4107RSM transcriptional regulator AM488_20475 ENOG4106TD9 Diguanylate cyclase AM488_20480 ENOG4105DHT Metal Dependent Phosphohydrolase AM488_20495 ENOG4105D1S lipid A biosynthesis AM488_20500 ENOG4108NIW Leucine export protein LeuE AM488_20505 ENOG4105S5I Membrane AM488_20520 ENOG4106G4W AM488_20525 ENOG410620I Diguanylate cyclase AM488_20530 ENOG4105UCG Domain of unknown function (DUF333) AM488_20535 ENOG4105K78 MarR family Transcriptional regulator AM488_20540 ENOG4105EWC Purine nucleoside phosphorylase AM488_20545 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AM488_20550 ENOG4105DJ2 Major Facilitator Superfamily AM488_20555 ENOG4105R1U AraC Family Transcriptional Regulator AM488_20560 ENOG4108VMM UPF0756 membrane protein AM488_20565 ENOG4108KXH Ybak prolyl-tRNA synthetase associated AM488_20570 ENOG4108XNZ glycosyl transferase AM488_20575 ENOG4105Y50 Virulence Protein AM488_20585 ENOG4105EKQ RNA-directed DNA polymerase AM488_20590 ENOG4105KT5 UmuD protein AM488_20595 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AM488_20600 ENOG4105CBN LysR family transcriptional regulator AM488_20605 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AM488_20625 ENOG4108V06 Glutathione peroxidase AM488_20635 ENOG4106AKX UPF0229 protein AM488_20640 ENOG4105CYN Serine protein kinase AM488_20645 ENOG4105GNX MltA-interacting MipA family protein AM488_20650 ENOG4105CV8 reductase AM488_20655 ENOG4105DSB aldose 1-epimerase AM488_20660 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AM488_20665 ENOG4105E0X reductase AM488_20670 ENOG4105VUT cytoplasmic protein AM488_20675 ENOG4105N1F Hnh endonuclease AM488_20685 ENOG4105CPQ Dehydrogenase AM488_20690 ENOG4107TE1 transport protein AM488_20695 ENOG4105CPQ Dehydrogenase AM488_20700 ENOG4105D2N Aldolase AM488_20705 ENOG4107UH8 sugar kinase AM488_20710 ENOG4105CPC Aldo Keto reductase AM488_20715 ENOG4105E98 transcriptional regulator DeoR family AM488_20720 ENOG4108KUU Inner membrane metabolite transport protein ydjE AM488_20725 ENOG4108RWI nicotinamidase AM488_20730 ENOG4105HDK L-asparaginase AM488_20735 ENOG4105D07 Signal peptide peptidase, SppA AM488_20740 ENOG41069NU Nitroreductase AM488_20755 ENOG4105SBG acid phosphatase AM488_20760 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) AM488_20765 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AM488_20775 ENOG4105D82 Glutamate dehydrogenase AM488_20780 ENOG4105M6F mutator MutT protein AM488_20785 ENOG4108T9J Cdp-alcohol phosphatidyltransferase AM488_20790 ENOG4107RM6 sulfurtransferase AM488_20795 ENOG4108VGW abc transporter atp-binding protein AM488_20800 ENOG4105CXZ ABC transporter, permease AM488_20805 ENOG4105VNH ABC transporter solute-binding protein AM488_20810 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AM488_20815 ENOG4108N5C SNARE associated Golgi protein-related protein AM488_20820 ENOG4108RSN SNARE associated Golgi AM488_20825 ENOG4105CGK Exodeoxyribonuclease III AM488_20835 ENOG4105F4X arginine AM488_20840 ENOG4105C26 Dehydrogenase AM488_20845 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) AM488_20855 ENOG4108SPG Periplasmic Protein AM488_20860 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) AM488_20870 ENOG4105KKI DNA-binding transcriptional activator OsmE AM488_20875 ENOG4105VZJ PTS System AM488_20880 ENOG4105CK1 PTS System AM488_20885 ENOG4105VCP PTS System AM488_20890 ENOG4105EZV Transcriptional regulator AM488_20895 ENOG4105F8D glycoside hydrolase family 4 AM488_20900 ENOG410901P UPF0249 protein AM488_20905 ENOG4105CH6 catalase AM488_20910 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) AM488_20915 ENOG4108ETY sodium dicarboxylate symporter AM488_20920 ENOG4107K5X Membrane-bound metal-dependent hydrolase AM488_20925 ENOG4105CHR reductase AM488_20930 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 AM488_20935 ENOG4107PN8 YfeABCD locus regulator AM488_20940 ENOG4105NAU thioesterase Superfamily protein AM488_20945 ENOG4107RNH Outer membrane receptor FepA AM488_20950 ENOG4107835 probably involved in intracellular septation (By similarity) AM488_20955 ENOG4108S3I UPF0259 membrane protein AM488_20960 ENOG4105PI0 Ferredoxin AM488_20965 ENOG4105EIF outer membrane protein W AM488_20970 ENOG4107E2E PKHD-type hydroxylase AM488_20975 ENOG4108IU3 tonb-dependent siderophore receptor AM488_21025 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AM488_21030 ENOG4105DK0 Indole-3-glycerol phosphate synthase AM488_21035 ENOG4108EFP Anthranilate synthase component II AM488_21040 ENOG4105CRQ synthase (Component I) AM488_21045 ENOG4105DB7 PHP domain protein AM488_21050 ENOG4107RTD sua5 ycio yrdc ywlc family protein AM488_21060 ENOG4105ETT transcriptional Regulator, LysR family AM488_21065 ENOG4105FE9 pseudouridine synthase AM488_21070 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase AM488_21075 ENOG4105UBK short-chain dehydrogenase reductase AM488_21085 ENOG4105ERU peptidase AM488_21090 ENOG4105RKX Protein of unknown function (DUF2498) AM488_21100 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AM488_21105 ENOG4107R11 Transcriptional regulator AM488_21120 ENOG4107QM5 aconitate hydratase AM488_21125 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AM488_21130 ENOG4105EYK Phosphatidylglycerophosphatase B AM488_21135 ENOG4105Q4A inner membrane protein yciS AM488_21140 ENOG4105CFV Tetratricopeptide repeat protein AM488_21150 ENOG4108ZJT translation initiation factor, Sui1 AM488_21155 ENOG41061RM osmotically inducible lipoprotein AM488_21160 ENOG4105N2W Transcriptional regulator AM488_21170 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) AM488_21175 ENOG4105Q4T oxidoreductase AM488_21180 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AM488_21190 ENOG4105ETS cytosine purines uracil thiamine allantoin AM488_21195 ENOG4108JQ2 peptide transport system atp-binding protein AM488_21200 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein AM488_21205 ENOG4108EU3 peptide transport system, permease AM488_21305 ENOG4105EKQ RNA-directed DNA polymerase AM488_21310 ENOG4105KT5 UmuD protein AM488_21315 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AM488_21325 ENOG4108RAV Conserved protein AM488_21330 ENOG4108I5W peptide transport system, permease protein AM488_21335 ENOG4108J59 Extracellular solute-binding protein, family 5 AM488_21350 ENOG41063ZK Transcriptional Regulator AraC Family AM488_21355 ENOG4105CH2 amidohydrolase AM488_21365 ENOG4105E51 psp operon transcriptional activator AM488_21370 ENOG41087YS Phage shock protein A AM488_21375 ENOG4105YYT phage shock protein B AM488_21380 ENOG4105FM1 phage shock protein C AM488_21385 ENOG4105NNG Peripheral inner membrane phage-shock protein AM488_21390 ENOG4105CM6 amino acid regulated cytosolic protein AM488_21395 ENOG4106K28 UPF0283 membrane protein AM488_21400 ENOG4105W8I Transcriptional regulator AM488_21405 ENOG4105F8D glycoside hydrolase family 4 AM488_21410 ENOG4108JU8 Transcriptional regulator AM488_21415 ENOG4108KK1 membrane protein AbrB duplication AM488_21420 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AM488_21425 ENOG4107S8C mandelate racemase muconate lactonizing AM488_21430 ENOG4105KXI murein peptide amidase A AM488_21435 ENOG4107QSI ABC, transporter AM488_21450 ENOG4105EQ2 LysR family Transcriptional regulator AM488_21455 ENOG4105ENX hydrolase AM488_21460 ENOG4107RTG Major Facilitator superfamily AM488_21485 ENOG4105CBN LysR family transcriptional regulator AM488_21500 ENOG4108Z0Z intracellular protease Pfpi family AM488_21505 ENOG4105DFP Integrase AM488_21605 ENOG4105HGD Antitermination protein AM488_21635 ENOG4108N0N Phage Terminase Large Subunit AM488_21640 ENOG4107ZQ5 Phage-associated protein, HI1409 family AM488_21710 ENOG4105E4C Lytic transglycosylase catalytic AM488_21800 ENOG4105EKQ RNA-directed DNA polymerase AM488_21815 ENOG4106FE3 DNA repair AM488_21820 ENOG4105DFP Integrase AM488_21920 ENOG4105HGD Antitermination protein AM488_21950 ENOG4108N0N Phage Terminase Large Subunit AM488_21955 ENOG4107ZQ5 Phage-associated protein, HI1409 family AM488_22025 ENOG4105E4C Lytic transglycosylase catalytic AM488_22115 ENOG4105EKQ RNA-directed DNA polymerase AM488_22130 ENOG4106FE3 DNA repair AM488_22155 ENOG4108ZG0 Ompa motb domain protein AM488_22165 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AM488_22255 ENOG4105F6U Short-chain dehydrogenase reductase Sdr AM488_22260 ENOG4108XFH Transcriptional regulator AM488_22285 ENOG4105HEI LysR family (Transcriptional regulator AM488_22310 ENOG4105EE1 crotonyl-CoA reductase AM488_22320 ENOG4105D01 (LipO)protein AM488_22330 ENOG4108UMI ABC transporter, permease AM488_22335 ENOG4105CGF Aromatic amino acid aminotransferase AM488_22345 ENOG4105F7P transcriptional regulator AsnC family AM488_22350 ENOG4105C85 amino acid AM488_22365 ENOG4105D9R oxidoreductase AM488_22370 ENOG4105E98 transcriptional regulator DeoR family AM488_22380 ENOG4107RX3 Mg2 transporter protein cora family protein AM488_22390 ENOG4105C1J atp-dependent rna helicase AM488_22400 ENOG4108RW8 Universal stress protein F AM488_22410 ENOG4105FCK Membrane AM488_22415 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) AM488_22430 ENOG41090X5 Heat shock protein hslJ AM488_22435 ENOG4105C5I Dehydrogenase AM488_22440 ENOG4108KF1 Membrane AM488_22445 ENOG4107H52 Dicarboxylate transport AM488_22450 ENOG410689M (LipO)protein AM488_22455 ENOG4105WXT Conserved Protein AM488_22460 ENOG4108WFR AraC Family Transcriptional Regulator AM488_22465 ENOG4105C26 Dehydrogenase AM488_22480 ENOG4105F11 amine oxidase AM488_22495 ENOG4105DXM phenylacetic acid degradation protein AM488_22500 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit AM488_22505 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit AM488_22510 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit AM488_22515 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit AM488_22520 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AM488_22525 ENOG4105E39 Enoyl-CoA hydratase AM488_22530 ENOG4108UKI Enoyl-CoA hydratase AM488_22535 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AM488_22540 ENOG4108ZJI phenylacetic acid degradation protein AM488_22545 ENOG4105CHU acetyl-coa acetyltransferase AM488_22550 ENOG4105DZS Phenylacetate-CoA ligase AM488_22555 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein AM488_22560 ENOG4108Z0R Transferase AM488_22570 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AM488_22575 ENOG4105CQ7 ATP-dependent helicase AM488_22585 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AM488_22605 ENOG410642W LysR family Transcriptional regulator AM488_22610 ENOG4108FN7 Aldo keto reductase AM488_22615 ENOG4105D82 Glutamate dehydrogenase AM488_22620 ENOG4105C8Y Acetylornithine aminotransferase AM488_22625 ENOG4105F4X arginine AM488_22630 ENOG4105C26 Dehydrogenase AM488_22635 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) AM488_22640 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) AM488_22650 ENOG4105CSH Transporter AM488_22655 ENOG4107DB1 DUF218 domain AM488_22660 ENOG4105C26 Dehydrogenase AM488_22665 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AM488_22670 ENOG4105VPI YqaE family transport protein AM488_22675 ENOG41064WM Uncharacterized protein YcgX AM488_22680 ENOG4105KSU Redox protein AM488_22685 ENOG41066VF YeeE YedE family protein AM488_22700 ENOG41061EV selenium-binding protein YdfZ AM488_22710 ENOG4105C87 Aminotransferase class I and II AM488_22715 ENOG4105CI1 PTS System AM488_22720 ENOG4107P2S Transcriptional regulator AM488_22725 ENOG4106J39 exported protein AM488_22730 ENOG4105EIP mannose-6-phosphate isomerase AM488_22735 ENOG4107GFK fumarate AM488_22740 ENOG4105C9Q fumarate hydratase class II AM488_22750 ENOG4105JJR Histidine kinase AM488_22760 ENOG4107EXC regulatoR AM488_22765 ENOG4105RA2 Membrane AM488_22770 ENOG410642E Short chain dehydrogenase AM488_22775 ENOG4105D5Q Arginine ornithine antiporter AM488_22785 ENOG4105C5D exported protein AM488_22795 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AM488_22800 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AM488_22805 ENOG410671Z uncharacterized protein ydiH AM488_22810 ENOG4105Q9Y Universal stress protein AM488_22815 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AM488_22820 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AM488_22830 ENOG4105CFC Transporter AM488_22835 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B AM488_22845 ENOG4106KR7 LysR family Transcriptional regulator AM488_22850 ENOG4108DG9 Smr protein MutS2 AM488_22855 ENOG4107HP6 Transcriptional regulator AM488_22865 ENOG4107QNJ CoA-transferase subunit B AM488_22870 ENOG4105CHU acetyl-coa acetyltransferase AM488_22875 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase AM488_22880 ENOG4105F2Z 3-oxoadipate enol-lactonase AM488_22885 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AM488_22905 ENOG4107GFK fumarate AM488_22930 ENOG4108MRH transcriptional regulatory protein AM488_22935 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AM488_22945 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AM488_22950 ENOG4105DWT malate dehydrogenase (quinone) AM488_22955 ENOG4108K70 Transcriptional regulator AM488_22960 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AM488_22965 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase AM488_22970 ENOG4107TT2 Auxin Efflux Carrier AM488_23000 ENOG4105DSF transport protein AM488_23005 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) AM488_23010 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) AM488_23020 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap AM488_23030 ENOG4105CTD carboxy-peptidase AM488_23035 ENOG4105D94 Major Facilitator Superfamily AM488_23040 ENOG4106NZI LysR family Transcriptional regulator AM488_23045 ENOG4105DAG ROK family AM488_23050 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AM488_23055 ENOG4105CMQ Chloride channel AM488_23060 ENOG4108NEM leader-binding protein dmsD AM488_23065 ENOG4107KGK dmso reductase anchor subunit AM488_23070 ENOG4105QAX Iron-sulfur AM488_23075 ENOG4107QY8 reductase AM488_23080 ENOG4105KBG Protein of unknown function (DUF1161) AM488_23090 ENOG4108MK9 spermidine N(1)-acetyltransferase AM488_23095 ENOG4105M5Q UPF0482 protein AM488_23100 ENOG4105KK4 UPF0060 membrane protein AM488_23105 ENOG4108I5G Major Facilitator superfamily AM488_23110 ENOG4105DEI Mannitol dehydrogenase AM488_23115 ENOG4108U51 Universal stress protein AM488_23120 ENOG4107XBN GntR Family Transcriptional Regulator AM488_23125 ENOG4105EMU Dehydrogenase AM488_23130 ENOG4105DGW oligopeptidase A AM488_23140 ENOG4105R1U AraC Family Transcriptional Regulator AM488_23145 ENOG4108RAV Conserved protein AM488_23150 ENOG4108WQH regulatoR AM488_23160 ENOG4108ZNX Heat shock protein AM488_23165 ENOG4108WTK competence damage-inducible protein AM488_23170 ENOG4105BZU Histidine kinase AM488_23190 ENOG4105C6Z Gluconate AM488_23195 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AM488_23200 ENOG4105FB2 class II Aldolase AM488_23205 ENOG4105G63 Type III effector Hrp-dependent AM488_23215 ENOG4105MVE transcriptional regulator AM488_23220 ENOG4108J4B Beta-lactamase AM488_23230 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AM488_23235 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) AM488_23240 ENOG4105CNT hydrolase family 2 AM488_23245 ENOG4105ETE Transcriptional regulator (LacI family AM488_23260 ENOG4105ECQ AraC Family Transcriptional Regulator AM488_23275 ENOG41083Z3 extracellular ligand-binding receptor AM488_23280 ENOG4105C32 Amino acid ABC transporter (Permease) AM488_23285 ENOG4105CNN ABC, transporter AM488_23295 ENOG4108IV0 ABC, transporter AM488_23305 ENOG4105E5W Transporter AM488_23310 ENOG4108594 Permease of the drug metabolite transporter AM488_23315 ENOG4106DNR multiple antibiotic resistance protein AM488_23320 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF AM488_23325 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes AM488_23330 ENOG41082NP Multiple antibiotic resistance AM488_23335 ENOG4105F27 Major Facilitator AM488_23340 ENOG4105JAB phenazine biosynthesis protein, phzf family AM488_23345 ENOG4105CHR reductase AM488_23350 ENOG4108R66 Conserved Protein AM488_23365 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AM488_23370 ENOG4105C0A alcohol dehydrogenase AM488_23375 ENOG4107S2N Type III effector Hrp-dependent AM488_23380 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AM488_23385 ENOG4105MVE transcriptional regulator AM488_23390 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AM488_23400 ENOG4105EGI Transcriptional regulator AM488_23405 ENOG4105C26 Dehydrogenase AM488_23410 ENOG4105CSV Glutaminase AM488_23415 ENOG4105M0C cytoplasmic protein AM488_23420 ENOG4105BZU Histidine kinase AM488_23430 ENOG4107QZW Altronate oxidoreductase AM488_23485 ENOG4105F9N Major Facilitator Superfamily AM488_23500 ENOG4105CBP Major Facilitator AM488_23505 ENOG4105EGI Transcriptional regulator AM488_23510 ENOG4105EA8 2-Nitropropane dioxygenase AM488_23515 ENOG4108UMI ABC transporter, permease AM488_23525 ENOG4105D01 (LipO)protein AM488_23535 ENOG4105VYA Uncharacterized conserved protein (DUF2132) AM488_23550 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions AM488_23570 ENOG4108KSA LysR family transcriptional regulator AM488_23575 ENOG41061H0 Monooxygenase AM488_23580 ENOG4105C2W permease AM488_23585 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) AM488_23590 ENOG4105VT2 5-hydroxyisourate hydrolase AM488_23595 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein AM488_23600 ENOG4105CAF HipA N-terminal domain protein AM488_23605 ENOG4105F32 YngK protein AM488_23615 ENOG4105CW0 outer membrane usher protein AM488_23620 ENOG4108VCD Chaperone AM488_23635 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AM488_23650 ENOG4105BZU Histidine kinase AM488_23655 ENOG4105NIV Esterase AM488_23670 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein AM488_23675 ENOG4105C54 Major Facilitator superfamily AM488_23685 ENOG4105F8D glycoside hydrolase family 4 AM488_23690 ENOG4105CI1 PTS System AM488_23695 ENOG4107YCY Transcriptional regulator AM488_23705 ENOG4105JQN Transcriptional regulator AM488_23715 ENOG4107VHA regulatoR AM488_23720 ENOG4105BZW Glycerate kinase AM488_23740 ENOG4105CHU acetyl-coa acetyltransferase AM488_23745 ENOG4105CHR reductase AM488_23750 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) AM488_23765 ENOG4105EDR glucose galactose transporter AM488_23770 ENOG4108RVA ribokinase AM488_23775 ENOG4105UP7 3-epimerase AM488_23800 ENOG4105CPC Aldo Keto reductase AM488_23810 ENOG4107SET aldo keto reductase AM488_23815 ENOG4105CPC Aldo Keto reductase AM488_23820 ENOG4105EQ2 LysR family Transcriptional regulator AM488_23825 ENOG4105RHY Pfam:UPF0157 AM488_23830 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta AM488_23840 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC AM488_23850 ENOG4105CXY transporter AM488_23855 ENOG4105CNW domain protein AM488_23870 ENOG4109066 lysm domain bon superfamily protein AM488_23900 ENOG4105ETE Transcriptional regulator (LacI family AM488_23905 ENOG4105C2J ABC transporter AM488_23910 ENOG4105CNN ABC, transporter AM488_23925 ENOG4107PP3 Acetylornithine deacetylase AM488_23940 ENOG4105HEI LysR family (Transcriptional regulator AM488_23945 ENOG4105CBN LysR family transcriptional regulator AM488_23955 ENOG410829K Lysine exporter protein (Lyse ygga) AM488_23960 ENOG4105DM4 PTS System AM488_23965 ENOG4108YRF PTS System AM488_23975 ENOG4105UP7 3-epimerase AM488_23980 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC AM488_23990 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia AM488_23995 ENOG4105ETE Transcriptional regulator (LacI family AM488_24005 ENOG4105FCD Major Facilitator AM488_24035 ENOG4105CSH Transporter AM488_24040 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain AM488_24045 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AM488_24055 ENOG4105CBN LysR family transcriptional regulator AM488_24070 ENOG4105C5R Aminotransferase AM488_24080 ENOG4105E5Q amino acid AbC transporter AM488_24100 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AM488_24125 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AM488_24145 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AM488_24170 ENOG41089BK Glutamine amido-transferase AM488_24185 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AM488_24195 ENOG4105CVJ phosphoglycerate mutase AM488_24230 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AM488_24235 ENOG4107QUY Guanine deaminase AM488_24240 ENOG4105BZU Histidine kinase AM488_24245 ENOG4105ETE Transcriptional regulator (LacI family AM488_24255 ENOG4105CIB oxidoreductase Domain protein AM488_24265 ENOG4105ETU transcriptional activator (TenA AM488_24270 ENOG4108YI8 ABC transporter AM488_24275 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component AM488_24280 ENOG4107Z6I Thiamine biosynthesis protein AM488_24285 ENOG4108JPW Aminotransferase AM488_24290 ENOG4105DY8 decarboxylase AM488_24305 ENOG4105E0F Histidine kinase AM488_24310 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AM488_24315 ENOG4108J2P Alpha beta hydrolase fold AM488_24320 ENOG4108IGT Dipeptidase AM488_24330 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) AM488_24335 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) AM488_24345 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E AM488_24350 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF AM488_24355 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AM488_24375 ENOG4106KR7 LysR family Transcriptional regulator AM488_24380 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AM488_24385 ENOG4105D6Z AFG1 family ATPase AM488_24390 ENOG4105KT7 mgtC SapB transporter AM488_24400 ENOG4108KUU Inner membrane metabolite transport protein ydjE AM488_24405 ENOG4105VCP PTS System AM488_24410 ENOG4105VZJ PTS System AM488_24435 ENOG4105CK1 PTS System AM488_24440 ENOG4105C5Q Transcriptional regulator AM488_24445 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AM488_24450 ENOG4105FFC UPF0187 protein AM488_24475 ENOG4108Z9K Osmotically inducible protein AM488_24480 ENOG4108YDI single-species biofilm formation on inanimate substrate AM488_24500 ENOG4105CG3 alpha amylase, catalytic region AM488_24510 ENOG4108N8X transition metal ion binding AM488_24530 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AM488_24535 ENOG4105N0E Protein of unknown function (DUF2543) AM488_24540 ENOG4105EQ2 LysR family Transcriptional regulator AM488_24555 ENOG4107R1I NAD-dependent malic enzyme AM488_24570 ENOG4105C5H ABC transporter AM488_24585 ENOG4105DQ4 alcohol dehydrogenase AM488_24600 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM488_24605 ENOG4108JQ6 ABC transporter AM488_24620 ENOG4105F27 Major Facilitator AM488_24630 ENOG4105CSR polyphosphate kinase 2 AM488_24645 ENOG4108MG3 formate dehydrogenase AM488_24650 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AM488_24675 ENOG4108UKV benzoate 1,2-dioxygenase AM488_24685 ENOG410626B catechol 1,2-dioxygenase AM488_24690 ENOG4105NN7 muconolactone delta-isomerase AM488_24695 ENOG4105DTQ mandelate racemase muconate lactonizing AM488_24700 ENOG4107HP6 Transcriptional regulator AM488_24715 ENOG4107QND Nitrite extrusion protein AM488_24720 ENOG4105CRU nitrate reductase, alpha subunit AM488_24725 ENOG4108IUE nitrate reductase beta subunit AM488_24730 ENOG4108NZN Respiratory nitrate reductase 2 delta chain AM488_24735 ENOG4105D0D Nitrate reductase 2, gamma subunit AM488_24740 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AM488_24745 ENOG4107RCV ABC transporter, permease AM488_24750 ENOG4105C4Y ABC transporter AM488_24755 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AM488_24760 ENOG4108MEJ flavin reductase domain protein AM488_24775 ENOG4105CT4 transporter AM488_24805 ENOG4108N27 Glutathione S-transferase AM488_24815 ENOG4105CDA abc transporter atp-binding protein AM488_24820 ENOG4105DRP amino acid AbC transporter AM488_24830 ENOG4105EAB amino acid AbC transporter AM488_24840 ENOG4105CH2 amidohydrolase AM488_24845 ENOG4105DEN Luciferase family AM488_24850 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AM488_24860 ENOG4105C85 amino acid AM488_24870 ENOG4108NS2 receptor AM488_24875 ENOG4105CHB tonB-dependent Receptor AM488_24880 ENOG4105CI2 imidazolone-5-propionate hydrolase AM488_24885 ENOG41065TG regulatoR AM488_24895 ENOG4105DU0 nucleoside hydrolase AM488_24900 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AM488_24910 ENOG4108Z7F N-acetyltransferase AM488_24915 ENOG4108T9Y Inner membrane protein ydcZ AM488_24920 ENOG4105R71 cytoplasmic protein AM488_24925 ENOG4105DEF Extracellular solute-binding protein, family 5 AM488_24935 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 AM488_24940 ENOG410654E Membrane AM488_24960 ENOG4105C26 Dehydrogenase AM488_24965 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component AM488_24970 ENOG4105D81 ABC transporter, permease AM488_24975 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AM488_24980 ENOG4107TYH extracellular solute-binding protein family 1 AM488_24985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AM488_24990 ENOG4105C4M (Ubiquinol oxidase) subunit I AM488_24995 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AM488_25015 ENOG4105CFP Peptidase U32 AM488_25025 ENOG4108JCI Transcriptional regulator AM488_25030 ENOG4105DKK Benzoate AM488_25035 ENOG4105UEI Transcriptional Regulator AraC Family AM488_25045 ENOG4108KKZ (LipO)protein AM488_25050 ENOG41088CC tellurite resistance protein tehB AM488_25055 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein AM488_25060 ENOG4107WE3 acetyltransferase YdcK AM488_25065 ENOG4108Z9I -acetyltransferase AM488_25080 ENOG4105EBR Carboxylesterase AM488_25085 ENOG4105E32 cytoplasmic protein AM488_25090 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta AM488_25095 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha AM488_25100 ENOG4105DDW LysR family Transcriptional regulator AM488_25120 ENOG4105CPW cytochrome b561 AM488_25135 ENOG4107YPT transcriptional regulator AM488_25140 ENOG4105EQ0 Major Facilitator superfamily AM488_25145 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AM488_25150 ENOG4105D9R oxidoreductase AM488_25160 ENOG4105CS2 ec 3.2.1.21 AM488_25170 ENOG4105M9B inner membrane protein ydgK AM488_25195 ENOG4108UQQ Electron transport complex AM488_25205 ENOG4105CSM endonuclease III AM488_25220 ENOG4108K3A Glutathione S-transferase AM488_25225 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) AM488_25230 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AM488_25235 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AM488_25240 ENOG410642K Lysozyme inhibitor AM488_25245 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AM488_25250 ENOG4108XTF Outer Membrane Lipoprotein AM488_25255 ENOG4105BZU Histidine kinase AM488_25270 ENOG4105Y49 secretion protein, HlyD family AM488_25275 ENOG4105DSW Fusaric acid resistance protein AM488_25280 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AM488_25285 ENOG4107RGM aldo keto reductase AM488_25290 ENOG4105XZD Fe-S protein AM488_25295 ENOG4108WUH Transcriptional regulator, TetR family AM488_25300 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AM488_25305 ENOG4108UYE Lactoylglutathione lyase AM488_25310 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) AM488_25315 ENOG4105M2J Glutaredoxin AM488_25320 ENOG4105K4H Nlp p60 protein AM488_25330 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AM488_25335 ENOG4105F27 Major Facilitator AM488_25345 ENOG4105ETE Transcriptional regulator (LacI family AM488_25350 ENOG4105F52 Transcriptional regulator AM488_25355 ENOG4105CZQ inner membrane transport protein YdhC AM488_25360 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AM488_25365 ENOG4108R6K riboflavin synthase, subunit alpha AM488_25370 ENOG4107QI1 Mate efflux family protein AM488_25380 ENOG4108URH decarboxylase AM488_25435 ENOG4105CY0 Metallo-Beta-Lactamase AM488_25455 ENOG4107B2H carbonic anhydrase AM488_25465 ENOG4105E98 transcriptional regulator DeoR family AM488_25470 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AM488_25495 ENOG4105C3U ABC transporter AM488_25500 ENOG4108JQ7 (ABC) transporter AM488_25560 ENOG4105EMY transcriptional regulator AM488_25575 ENOG4107TTD cytosine deaminase AM488_25580 ENOG4105KME endoribonuclease L-psp AM488_25600 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AM488_25605 ENOG4105CQB FAD linked oxidase domain protein AM488_25630 ENOG4106NZI LysR family Transcriptional regulator AM488_25640 ENOG4107QNJ CoA-transferase subunit B AM488_25650 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) AM488_25655 ENOG4105CY2 Citrate transporter AM488_25660 ENOG4105DTD Dehydrogenase AM488_25675 ENOG4105C7K acetolactate synthase AM488_25680 ENOG4105CHR reductase AM488_25695 ENOG4105BZS acriflavin resistance protein AM488_25715 ENOG4105E3W Two component transcriptional regulator (Winged helix family AM488_25720 ENOG41062D9 Histidine kinase AM488_25735 ENOG410822N TonB family AM488_25775 ENOG4105KWW Biogenesis protein AM488_25780 ENOG4107QX9 Thiol disulfide interChange protein AM488_25785 ENOG4105DA4 cytochrome c-type biogenesis protein AM488_25800 ENOG41060IM Heme exporter protein AM488_25805 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AM488_25810 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) AM488_25840 ENOG4107Z33 ABC transporter, permease AM488_25845 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC AM488_25855 ENOG4105DG4 malate L-lactate dehydrogenase AM488_25860 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AM488_25865 ENOG4105CH2 amidohydrolase AM488_25880 ENOG41083G8 Multidrug resistance protein MdtM AM488_25895 ENOG4105CDA abc transporter atp-binding protein AM488_25900 ENOG4105E5Q amino acid AbC transporter AM488_25905 ENOG4106PMH Extracellular solute-binding protein family 3 AM488_25925 ENOG4105DQ5 transport system permease protein AM488_25930 ENOG4105E0A ABC, transporter AM488_25940 ENOG4108IY8 ABC, transporter AM488_25945 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AM488_25965 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AM488_25970 ENOG4106KR7 LysR family Transcriptional regulator AM488_25975 ENOG4108T2C cysteine dioxygenase type I AM488_25990 ENOG4108SC4 )-transporter AM488_25995 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) AM488_26000 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) AM488_26005 ENOG4105IKQ hydratase AM488_26010 ENOG4107UB2 Alpha beta hydrolase fold AM488_26020 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase AM488_26025 ENOG4108K2P TRANSCRIPTIONal AM488_26030 ENOG4105S10 periplasmic binding protein AM488_26035 ENOG4105EHG Permease protein AM488_26040 ENOG4108W0P ABC transporter AM488_26045 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein AM488_26050 ENOG4105E2X shikimate dehydrogenase AM488_26055 ENOG4105DJB Major Facilitator Superfamily AM488_26070 ENOG4105RFR Protein of unknown function (DUF2767) AM488_26080 ENOG4105CA9 Pyruvate kinase AM488_26090 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AM488_26095 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AM488_26100 ENOG4105C9B Cysteine desulfurase AM488_26105 ENOG4105JRK feS assembly protein SufD AM488_26110 ENOG4105C3K feS assembly ATPase SufC AM488_26115 ENOG4105DIW FeS assembly protein SUFB AM488_26120 ENOG4108Z4V iron-sulfur cluster assembly AM488_26135 ENOG4105KBX Transcriptional regulator, TetR family AM488_26140 ENOG4105DMF Dehydrogenase AM488_26165 ENOG4106KR7 LysR family Transcriptional regulator AM488_26175 ENOG4105EHG Permease protein AM488_26180 ENOG4105E0A ABC, transporter AM488_26190 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AM488_26210 ENOG4105Y3U Transglycosylase-associated protein AM488_26225 ENOG4105KA0 thioesterase Superfamily protein AM488_26230 ENOG4105CQB FAD linked oxidase domain protein AM488_26235 ENOG4105IPI Membrane AM488_26245 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AM488_26255 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AM488_26260 ENOG4106EDX Hemin uptake protein AM488_26265 ENOG4105CNG UPF0061 protein AM488_26270 ENOG4108QBX (LipO)protein AM488_26280 ENOG4108V06 Glutathione peroxidase AM488_26285 ENOG4105D01 (LipO)protein AM488_26290 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) AM488_26300 ENOG4105RQF LysR family Transcriptional regulator AM488_26305 ENOG4105MWK D-amino acid dehydrogenase, small subunit AM488_26320 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AM488_26325 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AM488_26335 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AM488_26340 ENOG41082NX 50s ribosomal protein l35 AM488_26345 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AM488_26360 ENOG4108NE3 Salt-induced outer membrane protein AM488_26365 ENOG4105DE4 1-phosphofructokinase AM488_26370 ENOG4105P10 Uncharacterized protein ydiZ AM488_26375 ENOG4105FGM Fructosamine kinase AM488_26380 ENOG410822N TonB family AM488_26385 ENOG4105K9H YciI-like protein AM488_26390 ENOG4108YYC ycei family AM488_26400 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AM488_26410 ENOG4105EYW Ion transport protein AM488_26415 ENOG4108JQ7 (ABC) transporter AM488_26420 ENOG4105C3U ABC transporter AM488_26425 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM488_26435 ENOG4108J59 Extracellular solute-binding protein, family 5 AM488_26440 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AM488_26450 ENOG4108EKI Dehydrogenase AM488_26455 ENOG4107104 thymidine kinase AM488_26465 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AM488_26470 ENOG4105I93 response regulator AM488_26475 ENOG4105D78 K07001 NTE family protein AM488_26485 ENOG4105CIY formyltetrahydrofolate deformylase AM488_26525 ENOG41076YT nitrate reductase, gamma subunit AM488_26530 ENOG4105R3A Nitrate reductase AM488_26535 ENOG4108IUE nitrate reductase beta subunit AM488_26540 ENOG4105CRU nitrate reductase, alpha subunit AM488_26545 ENOG4105DQQ Major facilitator superfamily MFS_1 AM488_26550 ENOG4105BZU Histidine kinase AM488_26555 ENOG4105WH1 Two component transcriptional regulator luxr family AM488_26560 ENOG4105ID0 Putative invasin AM488_26570 ENOG4107QZF nitrite reductase NADPH large subunit AM488_26575 ENOG4105D7T ABC transporter AM488_26585 ENOG4105I5W Transporter AM488_26595 ENOG41090EX DsrE family AM488_26605 ENOG4108NH8 Cation transport protein AM488_26610 ENOG4105WS7 Cation transport regulator AM488_26615 ENOG4105EWV Sodium calcium exchanger membrane region AM488_26625 ENOG41063JG Transcriptional regulator AM488_26630 ENOG4108YY7 Invasion gene expression up-regulator SirB AM488_26635 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AM488_26640 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AM488_26645 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AM488_26650 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) AM488_26655 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AM488_26665 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AM488_26670 ENOG4105CHH sulfate transporter AM488_26680 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria AM488_26690 ENOG4105C3G gtp-binding protein AM488_26770 ENOG4105E6M Sulphatase-modifying factor protein AM488_26835 ENOG4105CS6 Rhs element vgr protein AM488_26840 ENOG4108ZG0 Ompa motb domain protein AM488_26865 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme AM488_26870 ENOG4105D3G Pseudouridine synthase AM488_26880 ENOG4105F04 LysR family Transcriptional regulator AM488_26890 ENOG4105CSH Transporter AM488_26910 ENOG4107YNJ LysR family Transcriptional regulator AM488_26915 ENOG4108IV0 ABC, transporter AM488_26920 ENOG4105C0Z ABC transporter AM488_26925 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AM488_26930 ENOG4105C32 Amino acid ABC transporter (Permease) AM488_26940 ENOG4105C6N Formate acetyltransferase AM488_26955 ENOG4105C7B Threonine dehydratase AM488_26960 ENOG410811B TRANSCRIPTIONal AM488_27015 ENOG4105E0K tonB-dependent siderophore receptor AM488_27020 ENOG4106JQ5 Transglycosylase SLT domain AM488_27025 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AM488_27030 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) AM488_27065 ENOG4105T95 Thiol disulfide interChange protein AM488_27275 ENOG4105DAX Pfam:DUF2983 AM488_27295 ENOG4108M24 von Willebrand factor, type A AM488_27305 ENOG4108M24 von Willebrand factor, type A AM488_27310 ENOG4108M24 von Willebrand factor, type A AM488_27330 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) AM488_27340 ENOG4108YXQ IS66 Orf2 family protein AM488_27345 ENOG4105E5H Transposase AM488_27360 ENOG4108YXQ IS66 Orf2 family protein AM488_27365 ENOG4105E5H Transposase AM488_27370 ENOG4105EQR Transposase IS116 IS110 IS902 AM488_27410 ENOG4105EQR Transposase IS116 IS110 IS902 AM488_27450 ENOG4105CHR reductase AM488_27455 ENOG4107ZXU DSBA oxidoreductase AM488_27460 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AM488_27510 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AM488_27550 ENOG4105EQR Transposase IS116 IS110 IS902 AM488_27605 ENOG4105EQR Transposase IS116 IS110 IS902 AM488_27615 ENOG4105CW0 outer membrane usher protein AM488_27625 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A AM488_27720 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) AM488_27750 ENOG4106JVB Replication Protein AM488_27770 ENOG4105KF5 hemolysin expression-modulating protein AM488_27780 ENOG4105EKQ RNA-directed DNA polymerase AM488_27880 ENOG4105C4R Atp-dependent dna helicase AM488_28175 ENOG4106CVF DNA replication protein AM488_28210 ENOG4105XPH Ferredoxin AM488_28255 ENOG4105C7B Threonine dehydratase AM488_28265 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) AM488_28270 ENOG4105DT3 PTS system, galactitol-specific IIc component AM488_28285 ENOG4105CMT Dihydroxyacetone kinase AM488_28300 ENOG4105RKW reductase (By AM488_28305 ENOG4108UTZ Dihydroxyacetone kinase AM488_28310 ENOG4105CMT Dihydroxyacetone kinase AM488_28315 ENOG4105EMY transcriptional regulator AM488_28340 ENOG4105EQR Transposase IS116 IS110 IS902 AM488_28485 ENOG4105EQR Transposase IS116 IS110 IS902 AM488_28535 ENOG4105EKQ RNA-directed DNA polymerase AM488_28600 ENOG4108YDI single-species biofilm formation on inanimate substrate AM488_28605 ENOG41061MD high-affinity nickel-transporter AM488_28615 ENOG4107Y80 Major Facilitator superfamily AM488_28670 ENOG4105K4U addiction module toxin, RelE StbE family AM488_28675 ENOG41074AV Hok/gef family AM488_29025 ENOG4108Z3N Transcriptional regulator AM488_29070 ENOG41074AV Hok/gef family AM488_29105 ENOG4105FEQ ParB domain protein nuclease AM488_29180 ENOG4105EKQ RNA-directed DNA polymerase AM488_29220 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB AM488_29225 ENOG4105EZN Cobyrinic acid ac-diamide synthase AM488_29230 ENOG4106JVB Replication Protein AM488_29245 ENOG410620I Diguanylate cyclase AM488_29270 ENOG4108M8H domain protein AM488_29275 ENOG4105EXU Membrane AM488_29280 ENOG4105C94 Transporter AM488_29330 ENOG410624V efflux system protein AM488_29360 ENOG4105DR5 peptidase AM488_29370 ENOG4105E3B Multicopper oxidase AM488_29375 ENOG4105VR0 copper resistance AM488_29380 ENOG4105JDN Copper resistance protein AM488_29385 ENOG4108PG2 copper resistance AM488_29390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AM488_29395 ENOG4105GR3 Histidine kinase AM488_29415 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AM488_29430 ENOG4105CAU Arsenical resistance protein, ArsH AM488_29500 ENOG4105KF5 hemolysin expression-modulating protein AM488_29535 ENOG4105D0M Protease HtpX homolog AM488_29555 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AM488_29560 ENOG4105VN1 Heat shock protein AM488_29585 ENOG4105F2I Transposase AM488_29640 ENOG4105EQR Transposase IS116 IS110 IS902 AM488_29645 ENOG4105CIS alcohol dehydrogenase AM488_29655 ENOG4105ETE Transcriptional regulator (LacI family AM488_29665 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) AM488_29700 ENOG4106CQM replication AM488_29755 ENOG4105PDG Type IV secretion system protein VirB8 AM488_29795 ENOG4105KK6 nuclease AM488_29820 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AM488_29825 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AM488_29940 ENOG4105BZU Histidine kinase AM488_30005 ENOG41080ET plasmid maintenance system killer protein AM488_30010 ENOG41081XE plasmid maintenance system antidote protein, xre family AM488_30115 ENOG4107SKI cobyrinic Acid a,c-diamide synthase AM488_30140 ENOG4105EKQ RNA-directed DNA polymerase AM488_30185 ENOG4105EQR Transposase IS116 IS110 IS902 AM488_30205 ENOG4108R0M Aminoglycoside AM488_30300 ENOG4105I1F Resistance protein AM488_30355 ENOG4105I1F Resistance protein