locus-tag	class	description
AM488_00010	COG2944	sequence-specific DNA binding
AM488_00180	COG1192	Involved in chromosome partitioning
AM488_00260	COG2719	SpoVR family
AM488_00290	COG0179	Fumarylacetoacetate (FAA) hydrolase
AM488_00305	COG2894	cell division
AM488_00315	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AM488_00320	COG0318	PFAM AMP-dependent synthetase and ligase
AM488_00325	COG3065	identical protein binding
AM488_00350	COG2814	Major facilitator Superfamily
AM488_00370	COG1956	GAF domain-containing protein
AM488_00375	COG2995	paraquat-inducible protein a
AM488_00380	COG3008	intermembrane lipid transfer
AM488_00405	COG2990	Protein conserved in bacteria
AM488_00410	COG3039	Transposase
AM488_00425	COG1276	copper resistance
AM488_00430	COG2372	response to copper ion
AM488_00440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM488_00445	COG1770	oligopeptidase
AM488_00450	COG2979	Protein of unknown function (DUF533)
AM488_00455	COG3141	response to X-ray
AM488_00465	COG0800	Aldolase
AM488_00470	COG0129	dihydroxy-acid dehydratase activity
AM488_00475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AM488_00490	COG1737	Transcriptional regulator
AM488_00500	COG1560	Kdo2-lipid A biosynthetic process
AM488_00505	COG0739	heme binding
AM488_00510	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AM488_00520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM488_00545	COG0494	nUDIX hydrolase
AM488_00555	COG1335	isochorismatase
AM488_00560	COG1801	Protein of unknown function DUF72
AM488_00565	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AM488_00585	COG3102	Protein conserved in bacteria
AM488_00595	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AM488_00620	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM488_00630	COG1879	ABC-type sugar transport system periplasmic component
AM488_00640	COG1528	Iron-storage protein
AM488_00650	COG2211	Major facilitator Superfamily
AM488_00660	COG0477	Major facilitator Superfamily
AM488_00675	COG1528	Iron-storage protein
AM488_00685	COG0814	amino acid
AM488_00690	COG3012	SEC-C Motif Domain Protein
AM488_00690	COG3318	Belongs to the UPF0149 family
AM488_00720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AM488_00730	COG2197	response regulator
AM488_00740	COG2197	response regulator
AM488_00765	COG0366	Alpha amylase catalytic
AM488_00795	COG2354	Protein conserved in bacteria
AM488_00800	COG0697	spore germination
AM488_00805	COG3727	T/G mismatch-specific endonuclease activity
AM488_00810	COG0270	DNA (cytosine-5-)-methyltransferase activity
AM488_00815	COG1418	mRNA catabolic process
AM488_00830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM488_00880	COG0582	viral genome integration into host DNA
AM488_00925	COG1752	Esterase of the alpha-beta hydrolase superfamily
AM488_00985	COG2916	Histone family protein nucleoid-structuring protein H-NS
AM488_01025	COG0025	NhaP-type Na H and K H
AM488_01030	COG1309	transcriptional regulator
AM488_01035	COG0604	alcohol dehydrogenase
AM488_01055	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AM488_01065	COG0534	Mate efflux family protein
AM488_01085	COG3706	GGDEF domain
AM488_01110	COG3615	Tellurite resistance protein tehB
AM488_01115	COG5001	Diguanylate cyclase
AM488_01115	COG3300	MHYT domain
AM488_01130	COG0477	Major facilitator Superfamily
AM488_01135	COG0095	Lipoate-protein ligase
AM488_01140	COG0583	DNA-binding transcription factor activity
AM488_01145	COG1942	4-Oxalocrotonate Tautomerase
AM488_01155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AM488_01175	COG1289	transmembrane transporter activity
AM488_01190	COG2925	Exonuclease
AM488_01195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AM488_01200	COG0640	Transcriptional regulator
AM488_01205	COG0531	amino acid
AM488_01215	COG0583	DNA-binding transcription factor activity
AM488_01220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM488_01250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AM488_01275	COG3436	PFAM IS66 Orf2 family protein
AM488_01280	COG4372	Transposase
AM488_01405	COG0463	Glycosyl transferase, family 2
AM488_01410	COG1442	glycosyl transferase family 8
AM488_01410	COG1216	Glycosyl transferase, family 2
AM488_01465	COG1253	flavin adenine dinucleotide binding
AM488_01470	COG2982	Protein involved in outer membrane biogenesis
AM488_01485	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AM488_01495	COG0443	Heat shock 70 kDa protein
AM488_01500	COG2205	protein histidine kinase activity
AM488_01515	COG1301	dicarboxylic acid transport
AM488_01540	COG2205	protein histidine kinase activity
AM488_01545	COG0745	RESPONSE REGULATOR receiver
AM488_01560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM488_01570	COG1070	Carbohydrate kinase
AM488_01605	COG1830	Aldolase
AM488_01610	COG0351	phosphomethylpyrimidine kinase
AM488_01625	COG0583	DNA-binding transcription factor activity
AM488_01635	COG2252	PERMEase
AM488_01640	COG0583	DNA-binding transcription factor activity
AM488_01645	COG5455	response to cobalt ion
AM488_01665	COG4807	Protein conserved in bacteria
AM488_01675	COG3275	phosphorelay sensor kinase activity
AM488_01685	COG1174	glycine betaine transport
AM488_01690	COG1125	glycine betaine transport
AM488_01695	COG1174	glycine betaine transport
AM488_01700	COG1732	Glycine betaine
AM488_01705	COG1472	Belongs to the glycosyl hydrolase 3 family
AM488_01710	COG0277	FAD linked oxidase domain protein
AM488_01720	COG1686	Belongs to the peptidase S11 family
AM488_01730	COG0586	Pfam SNARE associated Golgi protein
AM488_01735	COG1538	Outer membrane efflux protein
AM488_01745	COG2723	6-phospho-beta-galactosidase activity
AM488_01760	COG3659	wide pore channel activity
AM488_01765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM488_01775	COG1346	cytolysis
AM488_01790	COG2949	membrane
AM488_01800	COG1129	ABC transporter
AM488_01815	COG2311	Membrane
AM488_01830	COG4771	TonB-dependent receptor
AM488_01845	COG0833	amino acid
AM488_01850	COG0583	DNA-binding transcription factor activity
AM488_01860	COG2855	membrane
AM488_01870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM488_01870	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AM488_01870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM488_01875	COG1105	Belongs to the carbohydrate kinase PfkB family
AM488_01880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_01880	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_01905	COG1312	Catalyzes the dehydration of D-mannonate
AM488_01910	COG0246	Mannitol dehydrogenase
AM488_01915	COG0523	cobalamin synthesis protein
AM488_01920	COG0671	phosphoesterase, PA-phosphatase related
AM488_01925	COG0791	NLP P60 protein
AM488_01930	COG2200	EAL domain
AM488_01935	COG4166	transmembrane transport
AM488_01940	COG4174	ABC transporter (Permease)
AM488_01945	COG4239	(ABC) transporter, permease
AM488_01950	COG4172	Belongs to the ABC transporter superfamily
AM488_01960	COG2814	Major facilitator Superfamily
AM488_01965	COG1187	pseudouridine synthase activity
AM488_01970	COG1061	Type III restriction enzyme res subunit
AM488_01990	COG0494	nUDIX hydrolase
AM488_01995	COG1349	DNA-binding transcription factor activity
AM488_02020	COG0628	permease
AM488_02035	COG0659	secondary active sulfate transmembrane transporter activity
AM488_02040	COG2239	Acts as a magnesium transporter
AM488_02045	COG4615	Cyclic peptide transporter
AM488_02050	COG3145	DNA-N1-methyladenine dioxygenase activity
AM488_02055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM488_02055	COG2169	Transcriptional regulator
AM488_02070	COG0642	Histidine kinase
AM488_02070	COG2198	Histidine kinase
AM488_02080	COG2205	protein histidine kinase activity
AM488_02080	COG0784	Response regulator, receiver
AM488_02110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM488_02120	COG0584	glycerophosphoryl diester phosphodiesterase
AM488_02125	COG2271	Major facilitator Superfamily
AM488_02130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AM488_02140	COG0247	lactate metabolic process
AM488_02150	COG2271	Major facilitator Superfamily
AM488_02160	COG1414	Transcriptional regulator
AM488_02175	COG5464	transposase or invertase
AM488_02185	COG0318	PFAM AMP-dependent synthetase and ligase
AM488_02210	COG1169	isochorismate synthase
AM488_02215	COG2153	protein acetylation
AM488_02230	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM488_02235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM488_02245	COG0839	Belongs to the complex I subunit 6 family
AM488_02260	COG1034	ATP synthesis coupled electron transport
AM488_02270	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AM488_02300	COG0583	DNA-binding transcription factor activity
AM488_02305	COG0436	Aminotransferase
AM488_02315	COG0471	metal ion transport
AM488_02315	COG0490	domain, Protein
AM488_02320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM488_02335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AM488_02340	COG0857	belongs to the CobB CobQ family
AM488_02340	COG0280	phosphate acetyltransferase
AM488_02345	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AM488_02350	COG0622	Phosphoesterase
AM488_02355	COG0625	glutathione transferase activity
AM488_02360	COG0625	glutathione transferase activity
AM488_02365	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AM488_02370	COG1090	epimerase
AM488_02380	COG4598	ABC transporter
AM488_02385	COG4160	amino acid transport
AM488_02390	COG4215	(ABC) transporter
AM488_02400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM488_02405	COG0163	prenyltransferase activity
AM488_02410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AM488_02415	COG1286	toxin biosynthetic process
AM488_02420	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AM488_02425	COG0285	dihydrofolate synthase activity
AM488_02435	COG0586	Pfam SNARE associated Golgi protein
AM488_02445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AM488_02465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM488_02480	COG3101	peptidyl-lysine hydroxylation
AM488_02485	COG0730	response to heat
AM488_02500	COG2890	protein-(glutamine-N5) methyltransferase activity
AM488_02510	COG2062	phosphohistidine phosphatase, SixA
AM488_02525	COG3691	Protein conserved in bacteria
AM488_02540	COG2853	Lipoprotein
AM488_02545	COG2116	formate transmembrane transporter activity
AM488_02565	COG0583	DNA-binding transcription factor activity
AM488_02570	COG0590	tRNA wobble adenosine to inosine editing
AM488_02575	COG2807	transmembrane transport
AM488_02585	COG0436	Aminotransferase
AM488_02595	COG3275	phosphorelay sensor kinase activity
AM488_02600	COG3279	Response regulator of the LytR AlgR family
AM488_02615	COG3961	Belongs to the TPP enzyme family
AM488_02620	COG0667	Aldo Keto reductase
AM488_02635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AM488_02640	COG2199	diguanylate cyclase activity
AM488_02640	COG2200	EAL domain
AM488_02655	COG3415	Transposase
AM488_02660	COG3415	Transposase
AM488_02695	COG0583	DNA-binding transcription factor activity
AM488_02700	COG0385	Bile acid
AM488_02705	COG3530	Putative quorum-sensing-regulated virulence factor
AM488_02725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AM488_02740	COG2190	(PTS) system
AM488_02760	COG4319	ketosteroid isomerase
AM488_02770	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AM488_02775	COG4208	sulfate ABC transporter
AM488_02780	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AM488_02785	COG4150	thiosulfate binding
AM488_02795	COG2837	iron assimilation
AM488_02815	COG0860	N-Acetylmuramoyl-L-alanine amidase
AM488_02835	COG4816	utilization protein
AM488_02865	COG4820	ethanolamine utilization protein (EutJ)
AM488_02900	COG4917	ethanolamine utilization protein
AM488_02905	COG4810	utilization protein
AM488_02915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AM488_02920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AM488_02925	COG5342	invasion associated locus B
AM488_02935	COG0493	'glutamate synthase
AM488_02935	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM488_02945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM488_02955	COG1393	Belongs to the ArsC family
AM488_02970	COG0400	carboxylic ester hydrolase activity
AM488_02975	COG1444	tRNA N-acetyltransferase activity
AM488_02980	COG2321	neutral zinc metallopeptidase
AM488_02990	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AM488_03000	COG2716	regulation of RNA biosynthetic process
AM488_03005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AM488_03010	COG0628	permease
AM488_03015	COG4783	chaperone-mediated protein folding
AM488_03020	COG1393	Belongs to the ArsC family
AM488_03035	COG2233	PERMEase
AM488_03045	COG2723	6-phospho-beta-galactosidase activity
AM488_03060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AM488_03070	COG0248	Ppx GppA phosphatase
AM488_03075	COG2200	EAL domain
AM488_03095	COG0641	radical SAM
AM488_03110	COG0517	IMP dehydrogenase activity
AM488_03110	COG0516	GMP reductase activity
AM488_03120	COG1645	bacterial-type flagellum-dependent swarming motility
AM488_03140	COG2976	Protein conserved in bacteria
AM488_03175	COG4953	penicillin-binding protein 1C
AM488_03180	COG2373	Large extracellular alpha-helical protein
AM488_03185	COG2897	thiosulfate sulfurtransferase activity
AM488_03205	COG2975	iron-sulfur cluster assembly
AM488_03210	COG0633	Ferredoxin
AM488_03230	COG0822	iron-sulfur transferase activity
AM488_03260	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AM488_03265	COG3683	transport system, periplasmic component
AM488_03270	COG3711	transcriptional antiterminator
AM488_03275	COG2814	Major facilitator Superfamily
AM488_03280	COG2017	converts alpha-aldose to the beta-anomer
AM488_03285	COG2814	Major facilitator Superfamily
AM488_03285	COG0477	Major facilitator Superfamily
AM488_03295	COG1940	carbohydrate kinase activity
AM488_03300	COG2259	Doxx family
AM488_03315	COG1017	nitric oxide dioxygenase activity
AM488_03315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM488_03320	COG0347	Belongs to the P(II) protein family
AM488_03325	COG2204	response regulator
AM488_03330	COG3170	Tfp pilus assembly protein FimV
AM488_03335	COG2205	protein histidine kinase activity
AM488_03340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AM488_03340	COG0047	phosphoribosylformylglycinamidine synthase activity
AM488_03350	COG0590	tRNA wobble adenosine to inosine editing
AM488_03355	COG0560	Phosphoserine phosphatase
AM488_03360	COG1737	Transcriptional regulator
AM488_03365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM488_03375	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AM488_03395	COG0681	Belongs to the peptidase S26 family
AM488_03405	COG3086	response to oxidative stress
AM488_03410	COG3026	antisigma factor binding
AM488_03415	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
AM488_03425	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AM488_03435	COG0513	Belongs to the DEAD box helicase family
AM488_03450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM488_03455	COG3118	belongs to the thioredoxin family
AM488_03470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM488_03475	COG5544	Lipoprotein
AM488_03480	COG0477	Major facilitator Superfamily
AM488_03505	COG0542	response to heat
AM488_03515	COG0564	pseudouridine synthase activity
AM488_03520	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM488_03525	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AM488_03535	COG1605	Chorismate mutase
AM488_03535	COG0077	Prephenate dehydratase
AM488_03545	COG1605	Chorismate mutase
AM488_03545	COG0287	Prephenate dehydrogenase
AM488_03550	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM488_03560	COG2199	diguanylate cyclase activity
AM488_03565	COG2885	chlorophyll binding
AM488_03600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AM488_03605	COG4137	Cytochrome C assembly protein
AM488_03610	COG4536	flavin adenine dinucleotide binding
AM488_03630	COG0497	DNA recombination
AM488_03645	COG2867	negative regulation of translational initiation
AM488_03675	COG3708	Transcriptional regulator
AM488_03675	COG2207	Transcriptional regulator
AM488_03680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM488_03715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM488_03725	COG0235	Class ii aldolase
AM488_03735	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_03750	COG2197	response regulator
AM488_03755	COG3539	Fimbrial protein
AM488_03765	COG3188	usher protein
AM488_03785	COG3121	Chaperone
AM488_03790	COG3539	Fimbrial protein
AM488_03795	COG1012	belongs to the aldehyde dehydrogenase family
AM488_03800	COG3284	Transcriptional regulator
AM488_03805	COG0583	DNA-binding transcription factor activity
AM488_03815	COG0640	Transcriptional regulator
AM488_03820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AM488_03835	COG2916	Histone family protein nucleoid-structuring protein H-NS
AM488_03860	COG4575	ribosome binding
AM488_03865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM488_03870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM488_03875	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM488_03885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AM488_03900	COG4176	ABC-type proline glycine betaine transport system permease component
AM488_03910	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AM488_03920	COG1846	Transcriptional regulator
AM488_03925	COG1566	PFAM secretion protein HlyD family protein
AM488_03930	COG2814	Major facilitator Superfamily
AM488_03935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AM488_03955	COG1238	metal cluster binding
AM488_03960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM488_03965	COG2823	Periplasmic or secreted lipoprotein
AM488_04015	COG1546	Belongs to the CinA family
AM488_04025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM488_04030	COG1121	(ABC) transporter
AM488_04040	COG2951	lytic endotransglycosylase activity
AM488_04045	COG3730	PTS system glucitol sorbitol-specific
AM488_04050	COG3732	PTS system glucitol sorbitol-specific
AM488_04060	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_04065	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_04070	COG1349	DNA-binding transcription factor activity
AM488_04100	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AM488_04105	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AM488_04110	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM488_04115	COG1609	Transcriptional regulator
AM488_04120	COG1263	PTS System
AM488_04120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM488_04125	COG2723	6-phospho-beta-galactosidase activity
AM488_04135	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AM488_04145	COG3260	NADH ubiquinone oxidoreductase 20
AM488_04150	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM488_04155	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AM488_04155	COG3261	NADH dehydrogenase
AM488_04160	COG0650	Formate hydrogenlyase subunit 4
AM488_04165	COG0651	ATP synthesis coupled electron transport
AM488_04170	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM488_04190	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AM488_04195	COG0298	carbon dioxide binding
AM488_04200	COG0409	Hydrogenase expression formation protein
AM488_04205	COG0309	Hydrogenase expression formation protein (HypE)
AM488_04215	COG2723	6-phospho-beta-galactosidase activity
AM488_04225	COG4580	involved in the transport of maltose and maltodextrins
AM488_04235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM488_04240	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM488_04245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM488_04250	COG1447	Phosphotransferase system cellobiose-specific component IIA
AM488_04255	COG1940	carbohydrate kinase activity
AM488_04260	COG1609	Transcriptional regulator
AM488_04265	COG0803	Belongs to the bacterial solute-binding protein 9 family
AM488_04270	COG1121	(ABC) transporter
AM488_04275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM488_04280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM488_04295	COG0679	Auxin Efflux Carrier
AM488_04315	COG3720	iron ion transport
AM488_04320	COG4558	Periplasmic binding protein
AM488_04325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM488_04370	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AM488_04375	COG0163	prenyltransferase activity
AM488_04400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM488_04405	COG4942	peptidase
AM488_04405	COG1388	LysM domain
AM488_04465	COG2234	aminopeptidase activity
AM488_04485	COG0720	synthase
AM488_04490	COG0602	queuosine metabolic process
AM488_04510	COG3956	TIGRFAM MazG family protein
AM488_04515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM488_04525	COG2205	protein histidine kinase activity
AM488_04525	COG3437	response regulator, receiver
AM488_04525	COG3850	Histidine kinase
AM488_04525	COG4999	Histidine kinase
AM488_04535	COG1929	Belongs to the glycerate kinase type-1 family
AM488_04540	COG4948	Mandelate Racemase Muconate Lactonizing
AM488_04545	COG4948	Mandelate Racemase Muconate Lactonizing
AM488_04550	COG2271	Major facilitator Superfamily
AM488_04555	COG0716	FMN binding
AM488_04560	COG0564	pseudouridine synthase activity
AM488_04565	COG3098	single-species biofilm formation
AM488_04580	COG1611	Belongs to the LOG family
AM488_04585	COG0814	amino acid
AM488_04590	COG1760	l-serine dehydratase
AM488_04595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM488_04605	COG0477	Major facilitator Superfamily
AM488_04615	COG1464	Belongs to the NlpA lipoprotein family
AM488_04620	COG2011	ABC-type metal ion transport system permease component
AM488_04625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AM488_04640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM488_04655	COG1454	alcohol dehydrogenase
AM488_04660	COG0235	Class ii aldolase
AM488_04665	COG0738	Major facilitator superfamily
AM488_04685	COG1349	DNA-binding transcription factor activity
AM488_04695	COG2363	Small membrane protein
AM488_04700	COG0583	DNA-binding transcription factor activity
AM488_04710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AM488_04715	COG2166	iron-sulfur cluster assembly
AM488_04720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AM488_04725	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AM488_04810	COG2875	Belongs to the precorrin methyltransferase family
AM488_04820	COG2241	protein methyltransferase activity
AM488_04855	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AM488_04890	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AM488_04925	COG1012	belongs to the aldehyde dehydrogenase family
AM488_04925	COG1454	alcohol dehydrogenase
AM488_04930	COG4656	Part of a membrane complex involved in electron transport
AM488_04940	COG4810	utilization protein
AM488_04960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AM488_04965	COG0860	N-Acetylmuramoyl-L-alanine amidase
AM488_04970	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AM488_04970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AM488_04980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM488_04985	COG1074	ATP-dependent DNA helicase activity
AM488_04990	COG1025	Belongs to the peptidase M16 family
AM488_04995	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AM488_05000	COG4967	type IV pilus modification protein PilV
AM488_05010	COG4795	General secretion pathway protein
AM488_05015	COG2165	general secretion pathway protein
AM488_05045	COG0861	Integral membrane protein TerC family
AM488_05055	COG0667	Aldo Keto reductase
AM488_05080	COG1609	Transcriptional regulator
AM488_05090	COG2186	Transcriptional regulator
AM488_05095	COG2723	6-phospho-beta-galactosidase activity
AM488_05100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM488_05105	COG1609	Transcriptional regulator
AM488_05110	COG0019	diaminopimelate decarboxylase activity
AM488_05115	COG0583	DNA-binding transcription factor activity
AM488_05120	COG1794	racemase activity, acting on amino acids and derivatives
AM488_05125	COG1917	Cupin 2, conserved barrel domain protein
AM488_05130	COG1175	transmembrane transport
AM488_05135	COG0395	ABC-type sugar transport system, permease component
AM488_05140	COG3842	ATPase activity
AM488_05170	COG2814	Major facilitator Superfamily
AM488_05175	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_05180	COG0823	Involved in the tonB-independent uptake of proteins
AM488_05185	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AM488_05190	COG0183	Belongs to the thiolase family
AM488_05205	COG0814	amino acid
AM488_05210	COG0667	Aldo Keto reductase
AM488_05260	COG0697	spore germination
AM488_05265	COG1846	Transcriptional regulator
AM488_05270	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AM488_05280	COG0582	viral genome integration into host DNA
AM488_05285	COG4974	Belongs to the 'phage' integrase family
AM488_05295	COG3539	Fimbrial protein
AM488_05300	COG3121	Chaperone
AM488_05305	COG3188	usher protein
AM488_05310	COG3539	Fimbrial protein
AM488_05315	COG3539	Fimbrial protein
AM488_05320	COG3539	Fimbrial protein
AM488_05330	COG2388	GCN5-related N-acetyl-transferase
AM488_05335	COG3592	Divergent 4Fe-4S mono-cluster
AM488_05350	COG1289	transmembrane transporter activity
AM488_05355	COG1538	Outer membrane efflux protein
AM488_05365	COG3104	oligopeptide transport
AM488_05370	COG1393	Belongs to the ArsC family
AM488_05375	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AM488_05410	COG0667	Aldo Keto reductase
AM488_05425	COG2814	Major facilitator Superfamily
AM488_05435	COG4942	peptidase
AM488_05460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AM488_05470	COG4974	Belongs to the 'phage' integrase family
AM488_05475	COG0716	FMN binding
AM488_05485	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AM488_05495	COG1272	protein, Hemolysin III
AM488_05505	COG1737	Transcriptional regulator
AM488_05510	COG2723	6-phospho-beta-galactosidase activity
AM488_05530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM488_05535	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_05555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM488_05560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM488_05565	COG0006	proline dipeptidase activity
AM488_05585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AM488_05590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM488_05605	COG2968	Membrane
AM488_05615	COG0668	transmembrane transport
AM488_05620	COG0191	fructose-bisphosphate aldolase activity
AM488_05635	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AM488_05640	COG0501	Belongs to the peptidase M48B family
AM488_05660	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AM488_05665	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_05695	COG1414	Transcriptional regulator
AM488_05700	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_05715	COG2146	nitrite reductase [NAD(P)H] activity
AM488_05755	COG2814	Major facilitator Superfamily
AM488_05765	COG2356	endonuclease I
AM488_05770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AM488_05775	COG0189	ligase activity
AM488_05795	COG2805	Type II/IV secretion system protein
AM488_05800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AM488_05805	COG0762	integral membrane protein
AM488_05820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM488_05830	COG3171	Protein conserved in bacteria
AM488_05840	COG1194	a g-specific adenine glycosylase
AM488_05855	COG2211	Major facilitator Superfamily
AM488_05860	COG1982	Orn Lys Arg decarboxylase major
AM488_05870	COG1811	Na channel or pump
AM488_05880	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AM488_05940	COG3423	Transcriptional regulator
AM488_05945	COG1278	Cold shock
AM488_05955	COG3423	Transcriptional regulator
AM488_06225	COG0626	cystathionine gamma-synthase activity
AM488_06230	COG0583	DNA-binding transcription factor activity
AM488_06250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM488_06255	COG0754	glutathionylspermidine amidase activity
AM488_06265	COG0625	glutathione transferase activity
AM488_06290	COG2211	Major facilitator Superfamily
AM488_06295	COG0848	biopolymer transport protein
AM488_06300	COG0811	peptide transport
AM488_06310	COG0626	cystathionine gamma-synthase activity
AM488_06315	COG0586	Pfam SNARE associated Golgi protein
AM488_06320	COG2207	Transcriptional regulator
AM488_06325	COG1979	alcohol dehydrogenase
AM488_06330	COG0656	L-ascorbic acid biosynthetic process
AM488_06340	COG1032	radical SAM domain protein
AM488_06345	COG2132	Multicopper oxidase
AM488_06350	COG0204	Acyl-transferase
AM488_06355	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AM488_06360	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AM488_06365	COG3111	PFAM Bacterial OB fold (BOF) protein
AM488_06370	COG0745	RESPONSE REGULATOR receiver
AM488_06375	COG0642	Histidine kinase
AM488_06380	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM488_06385	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AM488_06390	COG0187	DNA topoisomerase II activity
AM488_06395	COG3150	esterase
AM488_06400	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AM488_06405	COG3151	Protein conserved in bacteria
AM488_06410	COG0494	nUDIX hydrolase
AM488_06425	COG0754	glutathionylspermidine amidase activity
AM488_06430	COG3384	dioxygenase
AM488_06445	COG2960	long-chain fatty acid transporting porin activity
AM488_06465	COG3025	triphosphatase activity
AM488_06470	COG4991	sh3 domain protein
AM488_06485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AM488_06555	COG0358	DNA primase activity
AM488_06560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM488_06585	COG2197	response regulator
AM488_06590	COG2198	Histidine kinase
AM488_06590	COG2205	protein histidine kinase activity
AM488_06590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM488_06590	COG0784	Response regulator, receiver
AM488_06600	COG3247	response to pH
AM488_06680	COG2376	Dihydroxyacetone kinase
AM488_06685	COG1461	Dihydroxyacetone kinase
AM488_06700	COG2375	cellular response to nickel ion
AM488_06705	COG1695	Transcriptional regulator
AM488_06760	COG1902	pentaerythritol trinitrate reductase activity
AM488_06760	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM488_06780	COG1451	nucleotide metabolic process
AM488_06785	COG0673	inositol 2-dehydrogenase activity
AM488_06790	COG0861	Integral membrane protein TerC family
AM488_06805	COG2721	sulfolactate sulfo-lyase activity
AM488_06815	COG2271	Major facilitator Superfamily
AM488_06820	COG2186	Transcriptional regulator
AM488_06825	COG0586	Pfam SNARE associated Golgi protein
AM488_06835	COG1422	Protein of unknown function (DUF1090)
AM488_06840	COG4575	ribosome binding
AM488_06845	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
AM488_06855	COG2259	Doxx family
AM488_06860	COG0435	Glutathione S-transferase
AM488_06865	COG3152	Membrane
AM488_06870	COG0583	DNA-binding transcription factor activity
AM488_06875	COG1741	Belongs to the pirin family
AM488_06895	COG1929	Belongs to the glycerate kinase type-1 family
AM488_06900	COG2084	Dehydrogenase
AM488_06910	COG2271	Major facilitator Superfamily
AM488_06915	COG2721	sulfolactate sulfo-lyase activity
AM488_06920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM488_06925	COG1349	DNA-binding transcription factor activity
AM488_06935	COG1105	Belongs to the carbohydrate kinase PfkB family
AM488_06940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM488_06940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM488_06940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_06945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_06945	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_06955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_06960	COG3414	Phosphotransferase system galactitol-specific IIB component
AM488_06965	COG3775	system Galactitol-specific IIC component
AM488_06970	COG1063	alcohol dehydrogenase
AM488_06985	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AM488_07005	COG2823	Periplasmic or secreted lipoprotein
AM488_07010	COG0701	Predicted permease
AM488_07015	COG0702	epimerase
AM488_07020	COG0693	protein deglycase activity
AM488_07035	COG3153	acetyltransferase
AM488_07055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM488_07060	COG0814	amino acid
AM488_07110	COG0195	Participates in both transcription termination and antitermination
AM488_07150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AM488_07160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AM488_07165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM488_07175	COG1534	Rna-binding protein
AM488_07180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM488_07185	COG2027	D-alanyl-D-alanine carboxypeptidase
AM488_07195	COG0697	spore germination
AM488_07210	COG0142	geranyltranstransferase activity
AM488_07215	COG3423	Transcriptional regulator
AM488_07225	COG5007	Belongs to the BolA IbaG family
AM488_07230	COG3113	response to antibiotic
AM488_07235	COG2854	intermembrane phospholipid transfer
AM488_07240	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AM488_07245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AM488_07250	COG1127	ABC transporter
AM488_07260	COG0530	calcium, potassium:sodium antiporter activity
AM488_07270	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AM488_07275	COG3117	lipopolysaccharide transmembrane transporter activity
AM488_07280	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AM488_07285	COG1137	ATPase activity
AM488_07290	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AM488_07295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AM488_07300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_07310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_07315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM488_07320	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AM488_07325	COG2198	Histidine kinase
AM488_07325	COG5002	protein histidine kinase activity
AM488_07325	COG0784	Response regulator, receiver
AM488_07330	COG1312	Catalyzes the dehydration of D-mannonate
AM488_07335	COG1063	alcohol dehydrogenase
AM488_07340	COG2271	Major facilitator Superfamily
AM488_07345	COG1242	4 iron, 4 sulfur cluster binding
AM488_07355	COG0070	glutamate synthase
AM488_07355	COG0067	glutamate synthase
AM488_07355	COG0069	glutamate synthase activity
AM488_07360	COG0493	'glutamate synthase
AM488_07370	COG2969	positive regulation of protein catabolic process
AM488_07375	COG0625	glutathione transferase activity
AM488_07395	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AM488_07400	COG3105	Protein conserved in bacteria
AM488_07405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM488_07410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM488_07435	COG2732	(Barnase) inhibitor
AM488_07440	COG1289	transmembrane transporter activity
AM488_07455	COG0583	DNA-binding transcription factor activity
AM488_07460	COG0312	modulator of DNA gyrase
AM488_07465	COG3164	Protein of unknown function
AM488_07470	COG1530	ribonuclease E activity
AM488_07480	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AM488_07485	COG1792	Involved in formation and maintenance of cell shape
AM488_07490	COG1077	Cell shape determining protein MreB Mrl
AM488_07500	COG2199	diguanylate cyclase activity
AM488_07500	COG2200	EAL domain
AM488_07510	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AM488_07530	COG0511	ligase activity, forming carbon-carbon bonds
AM488_07535	COG0439	Biotin carboxylase
AM488_07540	COG3924	membrane
AM488_07545	COG4145	pantothenate transmembrane transporter activity
AM488_07575	COG1802	Transcriptional regulator
AM488_07575	COG4626	Terminase
AM488_07665	COG3561	AntA/AntB antirepressor
AM488_07680	COG0582	viral genome integration into host DNA
AM488_07685	COG1309	transcriptional regulator
AM488_07690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM488_07695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM488_07735	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM488_07755	COG0551	DNA topoisomerase type I activity
AM488_07765	COG0758	DNA mediated transformation
AM488_07785	COG0569	domain protein
AM488_07795	COG3036	rescue of stalled ribosome
AM488_07800	COG0789	Transcriptional regulator
AM488_07815	COG0202	RNA polymerase activity
AM488_07840	COG0201	protein transport
AM488_07905	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AM488_07910	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AM488_07945	COG0051	transcription antitermination factor activity, RNA binding
AM488_07960	COG2906	2 iron, 2 sulfur cluster binding
AM488_08005	COG2964	Protein conserved in bacteria
AM488_08010	COG0545	Peptidyl-prolyl cis-trans isomerase
AM488_08020	COG1047	Peptidyl-prolyl cis-trans
AM488_08025	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AM488_08045	COG0488	(ABC) transporter
AM488_08055	COG0429	hydrolase of the alpha beta-hydrolase fold
AM488_08065	COG3954	Phosphoribulokinase
AM488_08070	COG1765	OsmC-like protein
AM488_08085	COG1289	transmembrane transporter activity
AM488_08090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM488_08115	COG0738	Major facilitator superfamily
AM488_08120	COG0402	S-adenosylhomocysteine deaminase activity
AM488_08125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM488_08130	COG2146	nitrite reductase [NAD(P)H] activity
AM488_08150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AM488_08155	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AM488_08160	COG3266	domain, Protein
AM488_08180	COG4796	Type ii and iii secretion system protein
AM488_08205	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AM488_08210	COG0494	nUDIX hydrolase
AM488_08220	COG1011	Hydrolase
AM488_08225	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AM488_08245	COG0745	RESPONSE REGULATOR receiver
AM488_08250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM488_08255	COG2183	response to ionizing radiation
AM488_08260	COG1918	ferrous iron import across plasma membrane
AM488_08285	COG1040	competence protein
AM488_08295	COG2610	gluconate transmembrane transporter activity
AM488_08300	COG1640	4-alpha-glucanotransferase
AM488_08305	COG0058	SHG alpha-glucan phosphorylase activity
AM488_08320	COG1349	DNA-binding transcription factor activity
AM488_08335	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AM488_08350	COG0058	SHG alpha-glucan phosphorylase activity
AM488_08375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AM488_08385	COG2610	gluconate transmembrane transporter activity
AM488_08390	COG3265	gluconokinase activity
AM488_08395	COG1609	Transcriptional regulator
AM488_08400	COG1741	Belongs to the pirin family
AM488_08405	COG0673	inositol 2-dehydrogenase activity
AM488_08415	COG1247	-acetyltransferase
AM488_08420	COG0405	Gamma-glutamyltransferase
AM488_08430	COG0584	glycerophosphoryl diester phosphodiesterase
AM488_08450	COG1653	transport
AM488_08465	COG0410	ABC transporter
AM488_08470	COG0411	ABC transporter
AM488_08480	COG0559	Belongs to the binding-protein-dependent transport system permease family
AM488_08485	COG0683	leucine binding
AM488_08500	COG0683	leucine binding
AM488_08510	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM488_08525	COG2177	Part of the ABC transporter FtsEX involved in
AM488_08530	COG2884	Cell division ATP-binding protein ftsE
AM488_08535	COG0552	protein localization to endoplasmic reticulum
AM488_08540	COG0742	ribosomal rna small subunit methyltransferase
AM488_08545	COG3776	membrane
AM488_08555	COG3714	YhhN family
AM488_08570	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AM488_08580	COG0477	Major facilitator Superfamily
AM488_08585	COG0628	permease
AM488_08625	COG3479	Phenolic acid decarboxylase
AM488_08640	COG0747	negative chemotaxis
AM488_08645	COG0601	transmembrane transport
AM488_08650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM488_08660	COG1124	(ABC) transporter
AM488_08670	COG2239	Acts as a magnesium transporter
AM488_08675	COG2081	HI0933 family
AM488_08680	COG0306	phosphate transporter
AM488_08690	COG0589	response to stress
AM488_08710	COG0671	phosphoesterase, PA-phosphatase related
AM488_08715	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AM488_08720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM488_08730	COG1454	alcohol dehydrogenase
AM488_08740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM488_08745	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_08750	COG0583	DNA-binding transcription factor activity
AM488_08755	COG1295	ribonuclease BN
AM488_08760	COG0477	Major facilitator Superfamily
AM488_08765	COG2982	Protein involved in outer membrane biogenesis
AM488_08780	COG0612	Peptidase, M16
AM488_08795	COG2200	EAL domain
AM488_08795	COG2199	diguanylate cyclase activity
AM488_08800	COG3118	belongs to the thioredoxin family
AM488_08800	COG0457	Tetratricopeptide repeat
AM488_08805	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AM488_08810	COG1215	transferase activity, transferring glycosyl groups
AM488_08840	COG2194	sulfuric ester hydrolase activity
AM488_08855	COG0457	Tetratricopeptide repeat
AM488_08860	COG1215	transferase activity, transferring glycosyl groups
AM488_08885	COG4608	Belongs to the ABC transporter superfamily
AM488_08890	COG0444	Belongs to the ABC transporter superfamily
AM488_08895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM488_08900	COG0601	transmembrane transport
AM488_08905	COG0747	negative chemotaxis
AM488_08945	COG2223	nitrite transmembrane transporter activity
AM488_08950	COG5571	outer membrane autotransporter
AM488_08955	COG2818	Glycosylase
AM488_08960	COG0456	acetyltransferase
AM488_08965	COG0243	molybdopterin cofactor binding
AM488_08970	COG2885	chlorophyll binding
AM488_08975	COG1609	Transcriptional regulator
AM488_08985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM488_09010	COG2814	Major facilitator Superfamily
AM488_09015	COG2944	sequence-specific DNA binding
AM488_09020	COG1278	Cold shock
AM488_09055	COG3274	enterobacterial common antigen metabolic process
AM488_09060	COG4682	membrane
AM488_09065	COG4682	membrane
AM488_09085	COG4213	ABC transporter substrate-binding protein
AM488_09090	COG1129	ABC transporter
AM488_09095	COG4214	carbohydrate transport
AM488_09100	COG1609	Transcriptional regulator
AM488_09100	COG2207	Transcriptional regulator
AM488_09105	COG2992	FlgJ-related protein
AM488_09115	COG0366	Alpha amylase catalytic
AM488_09120	COG3977	Valine--pyruvate aminotransferase
AM488_09125	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM488_09130	COG1414	Transcriptional regulator
AM488_09135	COG3276	selenocysteine insertion sequence binding
AM488_09145	COG0625	glutathione transferase activity
AM488_09150	COG1566	PFAM secretion protein HlyD family protein
AM488_09170	COG3722	fumarate hydratase activity
AM488_09190	COG2186	Transcriptional regulator
AM488_09200	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AM488_09220	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM488_09225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AM488_09235	COG4942	peptidase
AM488_09240	COG2861	carbohydrate metabolic process
AM488_09245	COG0463	Glycosyl transferase, family 2
AM488_09255	COG0156	8-amino-7-oxononanoate synthase activity
AM488_09270	COG0859	PFAM glycosyl transferase family 9
AM488_09295	COG0859	PFAM glycosyl transferase family 9
AM488_09305	COG0438	transferase activity, transferring glycosyl groups
AM488_09310	COG1216	Glycosyl transferase, family 2
AM488_09315	COG1519	Transferase
AM488_09350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AM488_09375	COG0842	Transport permease protein
AM488_09380	COG1131	(ABC) transporter
AM488_09400	COG1561	YicC-like family, N-terminal region
AM488_09405	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AM488_09410	COG2169	Transcriptional regulator
AM488_09410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM488_09420	COG2860	membrane
AM488_09440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM488_09445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM488_09450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AM488_09455	COG1494	fructose-1,6-bisphosphatase
AM488_09465	COG3152	Membrane
AM488_09490	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AM488_09510	COG0786	glutamate:sodium symporter activity
AM488_09515	COG2233	PERMEase
AM488_09520	COG2982	Protein involved in outer membrane biogenesis
AM488_09525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM488_09525	COG1263	PTS System
AM488_09530	COG1486	melibiose metabolic process
AM488_09540	COG1501	Belongs to the glycosyl hydrolase 31 family
AM488_09545	COG2211	Major facilitator Superfamily
AM488_09580	COG1064	alcohol dehydrogenase
AM488_09590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AM488_09605	COG1464	Belongs to the NlpA lipoprotein family
AM488_09630	COG0583	DNA-binding transcription factor activity
AM488_09660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM488_09665	COG1538	Outer membrane efflux protein
AM488_09670	COG2814	Major facilitator Superfamily
AM488_09680	COG1263	PTS System
AM488_09680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM488_09685	COG0697	spore germination
AM488_09700	COG2828	Protein conserved in bacteria
AM488_09705	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AM488_09710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AM488_09715	COG0583	DNA-binding transcription factor activity
AM488_09720	COG3384	dioxygenase
AM488_09730	COG1609	Transcriptional regulator
AM488_09740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM488_09740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM488_09745	COG1447	Phosphotransferase system cellobiose-specific component IIA
AM488_09750	COG4580	involved in the transport of maltose and maltodextrins
AM488_09785	COG2188	Transcriptional regulator
AM488_09830	COG2271	Major facilitator Superfamily
AM488_09840	COG2197	response regulator
AM488_09845	COG0440	acetolactate synthase activity
AM488_09850	COG0028	Belongs to the TPP enzyme family
AM488_09875	COG2814	Major facilitator Superfamily
AM488_09880	COG0583	DNA-binding transcription factor activity
AM488_09885	COG2610	gluconate transmembrane transporter activity
AM488_09905	COG2149	membrane
AM488_09920	COG2188	Transcriptional regulator
AM488_09930	COG3645	SOS response
AM488_09945	COG5645	(Lipo)protein
AM488_09950	COG0823	Involved in the tonB-independent uptake of proteins
AM488_09955	COG2271	Major facilitator Superfamily
AM488_09965	COG0800	Aldolase
AM488_09970	COG3734	2-keto-3-deoxy-galactonokinase
AM488_09975	COG2186	Transcriptional regulator
AM488_09990	COG0561	phosphatase activity
AM488_09995	COG0187	DNA topoisomerase II activity
AM488_10030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AM488_10065	COG2091	lysine biosynthetic process via aminoadipic acid
AM488_10070	COG0431	NADPH-dependent FMN reductase
AM488_10075	COG2252	PERMEase
AM488_10085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM488_10090	COG0363	glucosamine-6-phosphate deaminase activity
AM488_10095	COG2382	esterase
AM488_10110	COG0704	Plays a role in the regulation of phosphate uptake
AM488_10115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AM488_10120	COG0581	inorganic phosphate transmembrane transporter activity
AM488_10125	COG0573	inorganic phosphate transmembrane transporter activity
AM488_10130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM488_10135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM488_10185	COG3312	ion transport
AM488_10200	COG0716	FMN binding
AM488_10205	COG1522	sequence-specific DNA binding
AM488_10240	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM488_10245	COG1879	ABC-type sugar transport system periplasmic component
AM488_10250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM488_10255	COG1609	Transcriptional regulator
AM488_10260	COG0477	Major facilitator Superfamily
AM488_10265	COG2186	Transcriptional regulator
AM488_10295	COG1763	Mo-molybdopterin cofactor biosynthetic process
AM488_10305	COG3084	Protein conserved in bacteria
AM488_10310	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AM488_10320	COG0204	Acyl-transferase
AM488_10350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM488_10360	COG3852	Histidine kinase
AM488_10365	COG0174	glutamine synthetase
AM488_10380	COG1011	Hydrolase
AM488_10395	COG0456	acetyltransferase
AM488_10405	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM488_10420	COG2864	formate dehydrogenase
AM488_10425	COG0437	4 iron, 4 sulfur cluster binding
AM488_10450	COG0205	6-phosphofructokinase activity
AM488_10510	COG2211	Major facilitator Superfamily
AM488_10520	COG1454	alcohol dehydrogenase
AM488_10525	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM488_10530	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM488_10535	COG1129	ABC transporter
AM488_10540	COG1879	ABC-type sugar transport system periplasmic component
AM488_10580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AM488_10585	COG2258	MOSC domain
AM488_10590	COG2205	protein histidine kinase activity
AM488_10595	COG0745	RESPONSE REGULATOR receiver
AM488_10600	COG3678	ATP-independent chaperone mediated protein folding
AM488_10620	COG1575	Belongs to the MenA family. Type 1 subfamily
AM488_10635	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AM488_10640	COG1609	Transcriptional regulator
AM488_10645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AM488_10660	COG0626	cystathionine gamma-synthase activity
AM488_10665	COG0460	homoserine dehydrogenase
AM488_10665	COG0527	aspartate kinase activity
AM488_10675	COG0737	Belongs to the 5'-nucleotidase family
AM488_10685	COG0583	DNA-binding transcription factor activity
AM488_10695	COG0697	spore germination
AM488_10700	COG0371	Dehydrogenase
AM488_10710	COG2207	Transcriptional regulator
AM488_10715	COG3443	Belongs to the bacterial solute-binding protein 9 family
AM488_10730	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AM488_10755	COG0583	DNA-binding transcription factor activity
AM488_10830	COG3085	chromosome segregation
AM488_10850	COG3978	acetolactate synthase activity
AM488_10855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AM488_10865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM488_10870	COG0583	DNA-binding transcription factor activity
AM488_10880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM488_10885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM488_10895	COG1811	Na channel or pump
AM488_10925	COG3118	belongs to the thioredoxin family
AM488_10935	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AM488_10940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM488_10950	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AM488_10955	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AM488_10960	COG1088	dTDP-glucose 4,6-dehydratase activity
AM488_10965	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AM488_10970	COG0456	acetyltransferase
AM488_10975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AM488_10980	COG2244	polysaccharide biosynthetic process
AM488_11000	COG1113	amino acid transport
AM488_11025	COG3071	HemY protein
AM488_11030	COG2959	enzyme of heme biosynthesis
AM488_11045	COG3072	Adenylate cyclase
AM488_11055	COG5567	small periplasmic lipoprotein
AM488_11075	COG1011	Hydrolase
AM488_11080	COG0210	DNA helicase
AM488_11090	COG0598	Magnesium transport protein CorA
AM488_11100	COG2050	protein possibly involved in aromatic compounds catabolism
AM488_11115	COG1280	lysine exporter protein (LysE YggA)
AM488_11125	COG1280	lysine exporter protein (LysE YggA)
AM488_11130	COG2267	carboxylic ester hydrolase activity
AM488_11135	COG0561	phosphatase activity
AM488_11145	COG0583	DNA-binding transcription factor activity
AM488_11165	COG1322	Protein conserved in bacteria
AM488_11175	COG3165	ubiquinone biosynthetic process from chorismate
AM488_11185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AM488_11195	COG0805	protein transport
AM488_11240	COG1739	Uncharacterized protein family UPF0029
AM488_11250	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AM488_11280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AM488_11325	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AM488_11330	COG0250	Participates in transcription elongation, termination and antitermination
AM488_11370	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AM488_11375	COG1447	Phosphotransferase system cellobiose-specific component IIA
AM488_11385	COG3706	GGDEF domain
AM488_11405	COG2104	thiamine diphosphate biosynthetic process
AM488_11410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AM488_11425	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AM488_11445	COG3068	Protein conserved in bacteria
AM488_11450	COG0776	regulation of translation
AM488_11460	COG3678	ATP-independent chaperone mediated protein folding
AM488_11465	COG4191	Histidine kinase
AM488_11475	COG0151	Belongs to the GarS family
AM488_11520	COG0456	acetyltransferase
AM488_11530	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AM488_11570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AM488_11625	COG0527	aspartate kinase activity
AM488_11645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AM488_11655	COG0251	oxidation-reduction process
AM488_11730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AM488_11740	COG0534	Mate efflux family protein
AM488_11745	COG3237	CsbD-like
AM488_11750	COG0735	belongs to the Fur family
AM488_11760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM488_11775	COG0305	Participates in initiation and elongation during chromosome replication
AM488_11780	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AM488_11795	COG0432	Pfam Uncharacterised protein family UPF0047
AM488_11800	COG2315	Protein conserved in bacteria
AM488_11805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AM488_11820	COG0741	lytic transglycosylase activity
AM488_11825	COG4771	TonB-dependent receptor
AM488_11850	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM488_11865	COG0483	inositol monophosphate 1-phosphatase activity
AM488_11870	COG1609	Transcriptional regulator
AM488_11875	COG1234	tRNA 3'-trailer cleavage
AM488_11910	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AM488_11920	COG0789	Transcriptional regulator
AM488_11925	COG0625	glutathione transferase activity
AM488_11930	COG2252	PERMEase
AM488_11935	COG0025	NhaP-type Na H and K H
AM488_11940	COG0583	DNA-binding transcription factor activity
AM488_11945	COG1380	Effector of murein hydrolase LrgA
AM488_11950	COG1346	cytolysis
AM488_11955	COG3539	Fimbrial protein
AM488_11985	COG3162	membrane
AM488_11995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM488_12005	COG1301	dicarboxylic acid transport
AM488_12010	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AM488_12040	COG1879	ABC-type sugar transport system periplasmic component
AM488_12045	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM488_12050	COG1129	ABC transporter
AM488_12055	COG0784	Response regulator, receiver
AM488_12055	COG4191	Histidine kinase
AM488_12065	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AM488_12075	COG3454	Phosphonate metabolism
AM488_12080	COG4778	phosphonate C-P lyase system protein PhnL
AM488_12085	COG4107	phosphonate C-P lyase system protein PhnK
AM488_12090	COG3627	carbon phosphorus lyase activity
AM488_12095	COG3626	phosphonate metabolism
AM488_12100	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AM488_12105	COG3624	Phosphonate C-P lyase system protein PhnG
AM488_12110	COG2188	Transcriptional regulator
AM488_12115	COG2764	glyoxalase bleomycin resistance protein dioxygenase
AM488_12120	COG2824	Alkylphosphonate utilization operon protein PhnA
AM488_12135	COG2169	Transcriptional regulator
AM488_12145	COG1486	melibiose metabolic process
AM488_12180	COG0861	Integral membrane protein TerC family
AM488_12200	COG1215	transferase activity, transferring glycosyl groups
AM488_12205	COG1649	PFAM Uncharacterised BCR, COG1649
AM488_12205	COG0726	polysaccharide deacetylase
AM488_12210	COG0457	Tetratricopeptide repeat
AM488_12240	COG1309	transcriptional regulator
AM488_12255	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AM488_12260	COG1027	Aspartate ammonia-lyase
AM488_12270	COG3030	protein affecting phage T7 exclusion by the F plasmid
AM488_12275	COG0531	amino acid
AM488_12330	COG3121	Chaperone
AM488_12345	COG1509	lysine 2,3-aminomutase activity
AM488_12360	COG5510	response to toxic substance
AM488_12365	COG2076	Multidrug Resistance protein
AM488_12385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AM488_12390	COG1053	succinate dehydrogenase
AM488_12400	COG0531	amino acid
AM488_12405	COG3264	Mechanosensitive ion channel
AM488_12405	COG1511	domain protein
AM488_12430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM488_12455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AM488_12460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AM488_12460	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AM488_12465	COG0802	atpase or kinase
AM488_12470	COG0860	N-Acetylmuramoyl-L-alanine amidase
AM488_12490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AM488_12495	COG0330	HflC and HflK could
AM488_12500	COG0330	HflC and HflK could
AM488_12510	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AM488_12525	COG0557	exoribonuclease II activity
AM488_12530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM488_12535	COG1960	acyl-CoA dehydrogenase activity
AM488_12545	COG3650	response to hydrogen peroxide
AM488_12550	COG1073	alpha beta
AM488_12570	COG3414	Phosphotransferase system galactitol-specific IIB component
AM488_12610	COG2965	DNA replication, synthesis of RNA primer
AM488_12625	COG3061	Opacity-associated protein A
AM488_12630	COG0545	Peptidyl-prolyl cis-trans isomerase
AM488_12635	COG1113	amino acid transport
AM488_12645	COG0697	spore germination
AM488_12655	COG0702	epimerase
AM488_12660	COG1733	regulation of RNA biosynthetic process
AM488_12675	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AM488_12690	COG1253	flavin adenine dinucleotide binding
AM488_12700	COG0729	surface antigen
AM488_12705	COG2911	Protein conserved in bacteria
AM488_12710	COG2105	PFAM AIG2 family protein
AM488_12725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AM488_12730	COG1879	ABC-type sugar transport system periplasmic component
AM488_12735	COG1129	ABC transporter
AM488_12740	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM488_12745	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM488_12755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM488_12775	COG0312	modulator of DNA gyrase
AM488_12780	COG3783	Cytochrome b(562)
AM488_12810	COG3964	amidohydrolase
AM488_12825	COG2706	6-phosphogluconolactonase activity
AM488_12830	COG3711	transcriptional antiterminator
AM488_12830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_12835	COG3077	Addiction module antitoxin, RelB DinJ family
AM488_12840	COG2026	Addiction module toxin, RelE StbE family
AM488_12845	COG0602	queuosine metabolic process
AM488_12865	COG1486	melibiose metabolic process
AM488_12870	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM488_12875	COG0366	Alpha amylase catalytic
AM488_12880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM488_12880	COG1263	PTS System
AM488_12925	COG2731	YhcH YjgK YiaL family protein
AM488_12930	COG2222	sugar isomerase
AM488_12935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM488_12940	COG1228	amidohydrolase
AM488_12945	COG1288	antiporter activity
AM488_12950	COG2188	Transcriptional regulator
AM488_12960	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AM488_12975	COG0525	valine-tRNA ligase activity
AM488_12980	COG2927	DNA polymerase III (CHI subunit)
AM488_12995	COG0795	lipopolysaccharide-transporting ATPase activity
AM488_13000	COG0795	lipopolysaccharide-transporting ATPase activity
AM488_13005	COG0433	COG0433 Predicted ATPase
AM488_13020	COG3718	enzyme involved in inositol metabolism
AM488_13060	COG1737	Transcriptional regulator
AM488_13060	COG0837	glucose binding
AM488_13065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM488_13070	COG3962	Belongs to the TPP enzyme family
AM488_13080	COG1082	Xylose isomerase domain protein TIM barrel
AM488_13090	COG1653	transport
AM488_13095	COG3842	ATPase activity
AM488_13100	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AM488_13105	COG0395	ABC-type sugar transport system, permease component
AM488_13115	COG1064	alcohol dehydrogenase
AM488_13120	COG0659	secondary active sulfate transmembrane transporter activity
AM488_13125	COG0288	reversible hydration of carbon dioxide
AM488_13140	COG0582	viral genome integration into host DNA
AM488_13255	COG3507	Belongs to the glycosyl hydrolase 43 family
AM488_13260	COG2211	Major facilitator Superfamily
AM488_13270	COG4580	involved in the transport of maltose and maltodextrins
AM488_13275	COG3272	Protein of unknown function (DUF1722)
AM488_13295	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AM488_13310	COG0300	oxidoreductase activity
AM488_13320	COG0789	Transcriptional regulator
AM488_13325	COG3040	lipid binding
AM488_13335	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM488_13340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM488_13345	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM488_13350	COG1538	Outer membrane efflux protein
AM488_13360	COG0745	RESPONSE REGULATOR receiver
AM488_13365	COG5002	protein histidine kinase activity
AM488_13380	COG2850	peptidyl-arginine hydroxylation
AM488_13420	COG0842	Transport permease protein
AM488_13425	COG0842	Transport permease protein
AM488_13425	COG1129	ABC transporter
AM488_13430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM488_13440	COG1879	ABC-type sugar transport system periplasmic component
AM488_13445	COG1129	ABC transporter
AM488_13450	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM488_13460	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM488_13465	COG0583	DNA-binding transcription factor activity
AM488_13475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM488_13480	COG5457	Domain of unknown function (DUF1127)
AM488_13490	COG1566	PFAM secretion protein HlyD family protein
AM488_13505	COG1924	4 iron, 4 sulfur cluster binding
AM488_13510	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
AM488_13520	COG2814	Major facilitator Superfamily
AM488_13525	COG2733	membrane
AM488_13535	COG2207	Transcriptional regulator
AM488_13535	COG1917	Cupin 2, conserved barrel domain protein
AM488_13545	COG5464	transposase or invertase
AM488_13550	COG1012	belongs to the aldehyde dehydrogenase family
AM488_13560	COG0523	cobalamin synthesis protein
AM488_13565	COG2879	small protein
AM488_13570	COG1966	Carbon starvation protein
AM488_13585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM488_13590	COG2368	4-hydroxyphenylacetate
AM488_13610	COG3971	2-oxopent-4-enoate hydratase activity
AM488_13620	COG3384	dioxygenase
AM488_13625	COG1012	belongs to the aldehyde dehydrogenase family
AM488_13635	COG0179	Fumarylacetoacetate (FAA) hydrolase
AM488_13645	COG1846	Transcriptional regulator
AM488_13675	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AM488_13690	COG3734	2-keto-3-deoxy-galactonokinase
AM488_13695	COG0800	Aldolase
AM488_13700	COG1737	Transcriptional regulator
AM488_13710	COG1214	PFAM Peptidase M22, glycoprotease
AM488_13710	COG0456	acetyltransferase
AM488_13715	COG2271	Major facilitator Superfamily
AM488_13720	COG1802	Transcriptional regulator
AM488_13725	COG1063	alcohol dehydrogenase
AM488_13735	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AM488_13735	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AM488_13750	COG3715	PTS system
AM488_13755	COG3716	PTS system mannose fructose sorbose family IID component
AM488_13760	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM488_13770	COG5464	transposase or invertase
AM488_13785	COG1484	DNA-dependent DNA replication
AM488_13800	COG2966	Psort location CytoplasmicMembrane, score
AM488_13820	COG2197	response regulator
AM488_13825	COG2197	response regulator
AM488_13830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AM488_13835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM488_13835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM488_13840	COG4114	ferric iron reductase
AM488_13845	COG3706	GGDEF domain
AM488_13875	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
AM488_13880	COG0456	acetyltransferase
AM488_13885	COG1011	Hydrolase
AM488_13895	COG2823	Periplasmic or secreted lipoprotein
AM488_13905	COG4667	esterase of the alpha-beta hydrolase superfamily
AM488_13910	COG0084	hydrolase, TatD family'
AM488_13915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AM488_13955	COG0560	Phosphoserine phosphatase
AM488_13960	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AM488_13970	COG0488	(ABC) transporter
AM488_13980	COG0741	lytic transglycosylase activity
AM488_14000	COG2207	Transcriptional regulator
AM488_14000	COG3708	Transcriptional regulator
AM488_14005	COG3045	CreA protein
AM488_14010	COG0745	RESPONSE REGULATOR receiver
AM488_14015	COG2205	protein histidine kinase activity
AM488_14020	COG4452	Inner membrane protein CreD
AM488_14025	COG0745	RESPONSE REGULATOR receiver
AM488_14040	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AM488_14050	COG0527	aspartate kinase activity
AM488_14050	COG0460	homoserine dehydrogenase
AM488_14060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AM488_14075	COG1115	amino acid carrier protein
AM488_14085	COG0521	Mo-molybdopterin cofactor biosynthetic process
AM488_14090	COG0477	Major facilitator Superfamily
AM488_14095	COG1584	GPR1 FUN34 yaaH family protein
AM488_14100	COG4735	regulation of single-species biofilm formation
AM488_14125	COG0583	DNA-binding transcription factor activity
AM488_14140	COG0196	riboflavin kinase activity
AM488_14155	COG1047	Peptidyl-prolyl cis-trans
AM488_14180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AM488_14250	COG0505	Belongs to the CarA family
AM488_14305	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AM488_14315	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AM488_14320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AM488_14335	COG3493	citrate carrier protein
AM488_14350	COG0564	pseudouridine synthase activity
AM488_14360	COG0417	DNA replication proofreading
AM488_14365	COG0235	Class ii aldolase
AM488_14385	COG0586	Pfam SNARE associated Golgi protein
AM488_14395	COG1178	ABC-type Fe3 transport system permease component
AM488_14400	COG4143	(ABC) transporter
AM488_14415	COG2814	Major facilitator Superfamily
AM488_14420	COG2271	Major facilitator Superfamily
AM488_14425	COG0583	DNA-binding transcription factor activity
AM488_14435	COG0738	Major facilitator superfamily
AM488_14485	COG0028	Belongs to the TPP enzyme family
AM488_14495	COG1609	Transcriptional regulator
AM488_14520	COG0768	penicillin binding
AM488_14525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AM488_14530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AM488_14545	COG0772	Belongs to the SEDS family
AM488_14560	COG1181	Belongs to the D-alanine--D-alanine ligase family
AM488_14570	COG0849	cell division
AM488_14575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AM488_14595	COG0494	nUDIX hydrolase
AM488_14610	COG0237	dephospho-CoA kinase activity
AM488_14620	COG1459	type II secretion system
AM488_14625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AM488_14630	COG4969	Belongs to the N-Me-Phe pilin family
AM488_14640	COG3023	N-Acetylmuramoyl-L-alanine amidase
AM488_14645	COG3725	Membrane protein required for beta-lactamase induction
AM488_14650	COG3940	Belongs to the glycosyl hydrolase 43 family
AM488_14655	COG2211	Major facilitator Superfamily
AM488_14660	COG1113	amino acid transport
AM488_14665	COG2186	Transcriptional regulator
AM488_14670	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AM488_14675	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM488_14680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM488_14695	COG3064	Membrane
AM488_14755	COG2132	Multicopper oxidase
AM488_14760	COG4993	Dehydrogenase
AM488_14770	COG0288	reversible hydration of carbon dioxide
AM488_14775	COG1131	(ABC) transporter
AM488_14780	COG0842	Transport permease protein
AM488_14785	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_14790	COG0726	polysaccharide deacetylase
AM488_14810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AM488_14815	COG0617	tRNA 3'-terminal CCA addition
AM488_14825	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AM488_14835	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AM488_14840	COG1643	Atp-dependent helicase
AM488_14930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM488_14935	COG4774	siderophore transport
AM488_14940	COG1120	ATPase activity
AM488_14945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AM488_14950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM488_14970	COG2860	membrane
AM488_14990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM488_14995	COG3835	regulator
AM488_15010	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AM488_15015	COG0024	Methionine aminopeptidase
AM488_15040	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AM488_15055	COG0575	Belongs to the CDS family
AM488_15060	COG0750	zinc metalloprotease
AM488_15070	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AM488_15115	COG0346	lactoylglutathione lyase activity
AM488_15125	COG4568	rho-dependent transcription termination
AM488_15135	COG4681	YaeQ
AM488_15140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AM488_15145	COG3015	lipoprotein NlpE involved in copper resistance
AM488_15150	COG0791	NLP P60 protein
AM488_15160	COG1720	tRNA m6t6A37 methyltransferase activity
AM488_15170	COG1464	Belongs to the NlpA lipoprotein family
AM488_15175	COG2011	ABC-type metal ion transport system permease component
AM488_15185	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AM488_15225	COG0656	L-ascorbic acid biosynthetic process
AM488_15230	COG0583	DNA-binding transcription factor activity
AM488_15235	COG2814	Major facilitator Superfamily
AM488_15245	COG2226	methyltransferase
AM488_15250	COG0741	lytic transglycosylase activity
AM488_15250	COG1388	LysM domain
AM488_15260	COG2226	methyltransferase
AM488_15270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM488_15285	COG0583	DNA-binding transcription factor activity
AM488_15295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM488_15300	COG1960	acyl-CoA dehydrogenase activity
AM488_15310	COG0121	glutamine amidotransferase
AM488_15315	COG3034	peptidoglycan biosynthetic process
AM488_15335	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AM488_15340	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AM488_15355	COG2991	Protein conserved in bacteria
AM488_15370	COG0454	-acetyltransferase
AM488_15375	COG2195	Cleaves the N-terminal amino acid of tripeptides
AM488_15395	COG1802	Transcriptional regulator
AM488_15400	COG1113	amino acid transport
AM488_15405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM488_15410	COG1012	belongs to the aldehyde dehydrogenase family
AM488_15415	COG0579	oxidoreductase
AM488_15435	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AM488_15440	COG0625	glutathione transferase activity
AM488_15445	COG3775	system Galactitol-specific IIC component
AM488_15450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM488_15455	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_15460	COG1070	Carbohydrate kinase
AM488_15470	COG1830	Aldolase
AM488_15485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM488_15490	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM488_15495	COG0022	dehydrogenase e1 component
AM488_15500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AM488_15560	COG1192	Involved in chromosome partitioning
AM488_15565	COG0582	viral genome integration into host DNA
AM488_15590	COG0791	NLP P60 protein
AM488_15625	COG3639	organic phosphonate transmembrane transporter activity
AM488_15635	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AM488_15660	COG3188	usher protein
AM488_15675	COG0765	amino acid transport
AM488_15680	COG0765	amino acid transport
AM488_15685	COG1126	abc transporter atp-binding protein
AM488_15690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM488_15700	COG0410	ABC transporter
AM488_15705	COG0411	ABC transporter
AM488_15725	COG4302	ethanolamine ammonia-lyase activity
AM488_15730	COG4303	Ethanolamine ammonia lyase large subunit
AM488_15740	COG0833	amino acid
AM488_15745	COG2040	homocysteine
AM488_15750	COG4521	taurine ABC transporter
AM488_15755	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AM488_15760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM488_15765	COG2175	clavaminate synthase activity
AM488_15775	COG0113	porphobilinogen synthase activity
AM488_15780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AM488_15785	COG1335	isochorismatase
AM488_15790	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AM488_15810	COG1181	Belongs to the D-alanine--D-alanine ligase family
AM488_15830	COG1785	Belongs to the alkaline phosphatase family
AM488_15840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AM488_15850	COG3416	Protein conserved in bacteria
AM488_15855	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AM488_15865	COG4126	flavin adenine dinucleotide binding
AM488_15880	COG1940	carbohydrate kinase activity
AM488_15885	COG0419	ATPase involved in DNA repair
AM488_15890	COG0420	3'-5' exonuclease activity
AM488_15905	COG1114	Component of the transport system for branched-chain amino acids
AM488_15915	COG0366	Alpha amylase catalytic
AM488_15920	COG0583	DNA-binding transcription factor activity
AM488_15925	COG1335	isochorismatase
AM488_15935	COG1228	amidohydrolase
AM488_15945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM488_15960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_15965	COG0450	alkyl hydroperoxide reductase
AM488_15985	COG1862	Preprotein translocase
AM488_15990	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM488_15995	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM488_16015	COG4238	major outer membrane lipoprotein
AM488_16025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM488_16025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM488_16045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AM488_16050	COG0667	Aldo Keto reductase
AM488_16060	COG0142	geranyltranstransferase activity
AM488_16080	COG0693	protein deglycase activity
AM488_16085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AM488_16095	COG2814	Major facilitator Superfamily
AM488_16100	COG0673	inositol 2-dehydrogenase activity
AM488_16115	COG1053	succinate dehydrogenase
AM488_16125	COG1053	succinate dehydrogenase
AM488_16130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AM488_16135	COG1414	Transcriptional regulator
AM488_16150	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AM488_16155	COG1845	cytochrome c oxidase, subunit III
AM488_16160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AM488_16165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AM488_16170	COG2223	nitrite transmembrane transporter activity
AM488_16175	COG3056	Lipoprotein
AM488_16180	COG0271	Belongs to the BolA IbaG family
AM488_16210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AM488_16215	COG0776	regulation of translation
AM488_16220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM488_16225	COG1555	photosystem II stabilization
AM488_16230	COG0824	Thioesterase
AM488_16240	COG4533	DNA binding
AM488_16255	COG1522	sequence-specific DNA binding
AM488_16260	COG1132	(ABC) transporter
AM488_16265	COG1132	(ABC) transporter
AM488_16270	COG0347	Belongs to the P(II) protein family
AM488_16275	COG0004	ammonium transporteR
AM488_16280	COG1946	Acyl-CoA thioesterase
AM488_16285	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AM488_16290	COG3695	enzyme binding
AM488_16320	COG2364	Membrane
AM488_16335	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AM488_16345	COG2182	Extracellular solute-binding protein
AM488_16350	COG1175	transmembrane transport
AM488_16355	COG3833	ABC-type maltose transport systems, permease component
AM488_16360	COG3867	Arabinogalactan endo-beta-1,4-galactanase
AM488_16365	COG1874	Beta-galactosidase
AM488_16410	COG0110	maltose O-acetyltransferase activity
AM488_16425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM488_16430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM488_16435	COG1309	transcriptional regulator
AM488_16440	COG1196	nuclear chromosome segregation
AM488_16440	COG3264	Mechanosensitive ion channel
AM488_16445	COG5464	transposase or invertase
AM488_16455	COG3923	Primosomal replication protein n
AM488_16460	COG2832	Protein of unknown function (DUF454)
AM488_16505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM488_16510	COG4651	solute:proton antiporter activity
AM488_16510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM488_16515	COG2223	nitrite transmembrane transporter activity
AM488_16525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AM488_16530	COG3735	TraB family
AM488_16545	COG1585	Membrane protein implicated in regulation of membrane protease activity
AM488_16550	COG0330	HflC and HflK could
AM488_16555	COG4619	ABC transporter
AM488_16560	COG0390	transport system, permease component
AM488_16570	COG3118	belongs to the thioredoxin family
AM488_16575	COG0300	oxidoreductase activity
AM488_16580	COG2755	lipolytic protein G-D-S-L family
AM488_16585	COG4181	ATPase activity
AM488_16590	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AM488_16605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AM488_16610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AM488_16630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AM488_16640	COG2501	S4 domain
AM488_16700	COG3539	Fimbrial protein
AM488_16705	COG3121	Chaperone
AM488_16710	COG3188	usher protein
AM488_16725	COG1560	Kdo2-lipid A biosynthetic process
AM488_16735	COG3710	Transcriptional regulator
AM488_16740	COG0531	amino acid
AM488_16745	COG1982	Orn Lys Arg decarboxylase major
AM488_16750	COG3104	oligopeptide transport
AM488_16780	COG0673	inositol 2-dehydrogenase activity
AM488_16795	COG1129	ABC transporter
AM488_16800	COG4211	Belongs to the binding-protein-dependent transport system permease family
AM488_16845	COG1566	PFAM secretion protein HlyD family protein
AM488_16850	COG1120	ATPase activity
AM488_16855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM488_16875	COG1473	amidohydrolase
AM488_16880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM488_16885	COG0667	Aldo Keto reductase
AM488_16935	COG0531	amino acid
AM488_16945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM488_16950	COG1012	belongs to the aldehyde dehydrogenase family
AM488_16965	COG1113	amino acid transport
AM488_16970	COG2211	Major facilitator Superfamily
AM488_16980	COG0673	inositol 2-dehydrogenase activity
AM488_16990	COG2771	luxR family
AM488_17005	COG3188	usher protein
AM488_17035	COG0668	transmembrane transport
AM488_17040	COG0477	Major facilitator Superfamily
AM488_17060	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AM488_17060	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AM488_17065	COG2222	sugar isomerase
AM488_17070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM488_17075	COG3716	PTS system mannose fructose sorbose family IID component
AM488_17085	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM488_17095	COG0778	Nitroreductase
AM488_17100	COG2315	Protein conserved in bacteria
AM488_17150	COG3698	Phosphodiester glycosidase
AM488_17160	COG0697	spore germination
AM488_17175	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AM488_17180	COG0765	amino acid transport
AM488_17185	COG4215	(ABC) transporter
AM488_17195	COG4221	oxidoreductase activity
AM488_17205	COG4608	Belongs to the ABC transporter superfamily
AM488_17210	COG0444	Belongs to the ABC transporter superfamily
AM488_17215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM488_17220	COG0601	transmembrane transport
AM488_17225	COG0747	negative chemotaxis
AM488_17255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM488_17265	COG0668	transmembrane transport
AM488_17270	COG0583	DNA-binding transcription factor activity
AM488_17280	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_17290	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM488_17295	COG1129	ABC transporter
AM488_17305	COG1879	ABC-type sugar transport system periplasmic component
AM488_17310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AM488_17315	COG2390	Transcriptional regulator
AM488_17325	COG3959	Transketolase, thiamine diphosphate binding domain
AM488_17330	COG3958	Transketolase
AM488_17335	COG2977	Belongs to the P-Pant transferase superfamily
AM488_17340	COG4771	TonB-dependent receptor
AM488_17345	COG2382	esterase
AM488_17350	COG3251	PFAM MbtH domain protein
AM488_17355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM488_17355	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AM488_17360	COG1120	ATPase activity
AM488_17365	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM488_17370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM488_17380	COG4592	Periplasmic binding protein
AM488_17385	COG1169	isochorismate synthase
AM488_17390	COG1021	2,3-dihydroxybenzoate-AMP ligase
AM488_17395	COG3433	isochorismatase activity
AM488_17395	COG1535	isochorismatase
AM488_17400	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_17410	COG1966	Carbon starvation protein
AM488_17415	COG2879	small protein
AM488_17430	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_17435	COG0371	Dehydrogenase
AM488_17440	COG1129	ABC transporter
AM488_17445	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM488_17475	COG2271	Major facilitator Superfamily
AM488_17480	COG0483	inositol monophosphate 1-phosphatase activity
AM488_17490	COG0402	S-adenosylhomocysteine deaminase activity
AM488_17500	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AM488_17515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM488_17525	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM488_17530	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM488_17535	COG1129	ABC transporter
AM488_17560	COG0436	Aminotransferase
AM488_17565	COG1475	DNA binding
AM488_17570	COG3969	phosphoadenosine phosphosulfate
AM488_17575	COG0583	DNA-binding transcription factor activity
AM488_17580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM488_17585	COG0450	alkyl hydroperoxide reductase
AM488_17595	COG0589	response to stress
AM488_17600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM488_17605	COG3719	Belongs to the RNase T2 family
AM488_17610	COG3069	C4-dicarboxylate transmembrane transporter activity
AM488_17625	COG1278	Cold shock
AM488_17635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM488_17650	COG0583	DNA-binding transcription factor activity
AM488_17665	COG1686	Belongs to the peptidase S11 family
AM488_17670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AM488_17675	COG0772	Belongs to the SEDS family
AM488_17680	COG0768	penicillin binding
AM488_17690	COG0799	negative regulation of ribosome biogenesis
AM488_17710	COG1466	dna polymerase III delta subunit
AM488_17725	COG2888	peptidyl-tyrosine sulfation
AM488_17740	COG1126	abc transporter atp-binding protein
AM488_17745	COG0765	amino acid transport
AM488_17750	COG0765	amino acid transport
AM488_17765	COG4535	Mg2 and Co2 transporter CorC
AM488_17775	COG1702	phosphate starvation-inducible protein PhoH
AM488_17785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM488_17830	COG0367	asparagine synthase
AM488_17835	COG0647	UMP catabolic process
AM488_17840	COG1846	Transcriptional regulator
AM488_17840	COG1940	carbohydrate kinase activity
AM488_17845	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AM488_17890	COG0735	belongs to the Fur family
AM488_17905	COG0596	Alpha beta hydrolase
AM488_17915	COG0033	Phosphoglucomutase
AM488_17925	COG0745	RESPONSE REGULATOR receiver
AM488_17930	COG2205	protein histidine kinase activity
AM488_17960	COG0415	Belongs to the DNA photolyase family
AM488_17970	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AM488_17975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AM488_17980	COG1984	allophanate hydrolase subunit 2
AM488_18025	COG2009	succinate dehydrogenase
AM488_18030	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AM488_18035	COG1053	succinate dehydrogenase
AM488_18040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AM488_18045	COG0567	Dehydrogenase, E1 component
AM488_18050	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM488_18065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AM488_18075	COG1271	oxidase subunit
AM488_18080	COG1294	oxidase, subunit
AM488_18085	COG4890	Cyd operon protein YbgT
AM488_18090	COG3790	cyd operon protein YbgE
AM488_18095	COG0824	Thioesterase
AM488_18100	COG0811	peptide transport
AM488_18105	COG0848	biopolymer transport protein
AM488_18110	COG3064	Membrane
AM488_18120	COG2885	chlorophyll binding
AM488_18125	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AM488_18170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AM488_18175	COG3201	nicotinamide mononucleotide transporter
AM488_18190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM488_18200	COG2017	converts alpha-aldose to the beta-anomer
AM488_18210	COG1085	galactose-1-phosphate uridylyltransferase
AM488_18220	COG1119	ATPase activity
AM488_18225	COG3585	molybdate ion transport
AM488_18225	COG2005	Transcriptional regulator
AM488_18235	COG0725	ABC transporter, periplasmic molybdate-binding protein
AM488_18240	COG4149	molybdate abc transporter
AM488_18245	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AM488_18250	COG0561	phosphatase activity
AM488_18275	COG2200	EAL domain
AM488_18280	COG0789	Transcriptional regulator
AM488_18310	COG4677	pectinesterase activity
AM488_18345	COG1881	PFAM PEBP family protein
AM488_18350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AM488_18365	COG2226	methyltransferase
AM488_18375	COG0410	ABC transporter
AM488_18400	COG0642	Histidine kinase
AM488_18405	COG0745	RESPONSE REGULATOR receiver
AM488_18430	COG0521	Mo-molybdopterin cofactor biosynthetic process
AM488_18440	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AM488_18445	COG0314	molybdopterin synthase activity
AM488_18450	COG0670	Belongs to the BI1 family
AM488_18465	COG0392	lysyltransferase activity
AM488_18470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM488_18475	COG3568	Endonuclease Exonuclease Phosphatase
AM488_18490	COG0842	Transport permease protein
AM488_18495	COG0842	Transport permease protein
AM488_18500	COG1131	(ABC) transporter
AM488_18505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM488_18510	COG1309	transcriptional regulator
AM488_18515	COG0583	DNA-binding transcription factor activity
AM488_18520	COG2271	Major facilitator Superfamily
AM488_18525	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_18530	COG3959	Transketolase, thiamine diphosphate binding domain
AM488_18535	COG3958	Transketolase
AM488_18540	COG0513	Belongs to the DEAD box helicase family
AM488_18545	COG1199	ATP-dependent helicase activity
AM488_18550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AM488_18560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AM488_18570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM488_18580	COG0668	transmembrane transport
AM488_18585	COG1126	abc transporter atp-binding protein
AM488_18590	COG0765	amino acid transport
AM488_18595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM488_18610	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AM488_18615	COG2194	sulfuric ester hydrolase activity
AM488_18625	COG1321	iron dependent repressor
AM488_18630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AM488_18635	COG2723	6-phospho-beta-galactosidase activity
AM488_18640	COG2188	Transcriptional regulator
AM488_18645	COG1376	ErfK ybiS ycfS ynhG family protein
AM488_18650	COG2365	Tyrosine phosphatase family
AM488_18655	COG0488	(ABC) transporter
AM488_18670	COG2271	Major facilitator Superfamily
AM488_18675	COG1609	Transcriptional regulator
AM488_18685	COG0561	phosphatase activity
AM488_18695	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AM488_18700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AM488_18705	COG0303	'Molybdopterin
AM488_18720	COG0747	negative chemotaxis
AM488_18745	COG2223	nitrite transmembrane transporter activity
AM488_18755	COG2133	pyrroloquinoline quinone binding
AM488_18760	COG0625	glutathione transferase activity
AM488_18765	COG1686	Belongs to the peptidase S11 family
AM488_18770	COG1349	DNA-binding transcription factor activity
AM488_18775	COG0671	phosphoesterase, PA-phosphatase related
AM488_18785	COG2814	Major facilitator Superfamily
AM488_18790	COG0561	phosphatase activity
AM488_18795	COG0738	Major facilitator superfamily
AM488_18800	COG3226	Transcriptional regulator
AM488_18805	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AM488_18815	COG3344	reverse transcriptase
AM488_18855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AM488_18890	COG4695	Portal protein
AM488_19050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM488_19075	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AM488_19080	COG3842	ATPase activity
AM488_19085	COG1176	ABC-type spermidine putrescine transport system, permease component I
AM488_19090	COG1177	transmembrane transport
AM488_19105	COG0745	RESPONSE REGULATOR receiver
AM488_19110	COG5002	protein histidine kinase activity
AM488_19115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM488_19120	COG4160	amino acid transport
AM488_19125	COG4215	(ABC) transporter
AM488_19130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM488_19135	COG1126	abc transporter atp-binding protein
AM488_19150	COG2203	Gaf domain
AM488_19150	COG3706	GGDEF domain
AM488_19150	COG4251	negative regulation of phosphorylation
AM488_19150	COG5001	Diguanylate cyclase
AM488_19155	COG3023	N-Acetylmuramoyl-L-alanine amidase
AM488_19160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM488_19165	COG0702	epimerase
AM488_19170	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AM488_19175	COG0028	Belongs to the TPP enzyme family
AM488_19190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM488_19200	COG2431	L-lysine efflux transmembrane transporter activity
AM488_19205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AM488_19210	COG3593	DNA synthesis involved in DNA repair
AM488_19215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM488_19230	COG1278	Cold shock
AM488_19240	COG0542	response to heat
AM488_19255	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AM488_19260	COG4988	ABC transporter
AM488_19265	COG0492	ferredoxin-NADP+ reductase activity
AM488_19275	COG1178	ABC-type Fe3 transport system permease component
AM488_19275	COG1674	ftsk spoiiie
AM488_19285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AM488_19295	COG0243	molybdopterin cofactor binding
AM488_19300	COG0437	4 iron, 4 sulfur cluster binding
AM488_19305	COG3302	dmso reductase anchor subunit
AM488_19315	COG0477	Major facilitator Superfamily
AM488_19320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AM488_19325	COG1882	Formate acetyltransferase
AM488_19330	COG2116	formate transmembrane transporter activity
AM488_19335	COG1944	ATP diphosphatase activity
AM488_19340	COG2323	membrane
AM488_19360	COG0539	negative regulation of cytoplasmic translation
AM488_19370	COG2333	competence protein COMEC
AM488_19370	COG0658	competence protein
AM488_19385	COG3214	Protein conserved in bacteria
AM488_19400	COG3173	Aminoglycoside phosphotransferase
AM488_19405	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AM488_19410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM488_19420	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AM488_19430	COG2989	Protein conserved in bacteria
AM488_19440	COG3108	Peptidase M15
AM488_19445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM488_19450	COG1448	Aminotransferase
AM488_19455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM488_19475	COG1522	sequence-specific DNA binding
AM488_19485	COG0814	amino acid
AM488_19495	COG1473	amidohydrolase
AM488_19510	COG0308	aminopeptidase N
AM488_19520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM488_19525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM488_19530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM488_19535	COG0431	NADPH-dependent FMN reductase
AM488_19550	COG3217	Mosc domain protein beta barrel domain protein
AM488_19550	COG0633	Ferredoxin
AM488_19560	COG0488	(ABC) transporter
AM488_19565	COG2995	paraquat-inducible protein a
AM488_19570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AM488_19570	COG3008	intermembrane lipid transfer
AM488_19575	COG3009	Protein conserved in bacteria
AM488_19585	COG3130	regulation of translation
AM488_19595	COG1067	ATP-dependent peptidase activity
AM488_19620	COG3070	regulator of competence-specific genes
AM488_19625	COG1289	transmembrane transporter activity
AM488_19630	COG3304	Inner membrane component domain
AM488_19635	COG0210	DNA helicase
AM488_19645	COG1832	CoA-binding protein
AM488_19660	COG1881	PFAM PEBP family protein
AM488_19665	COG2207	Transcriptional regulator
AM488_19680	COG0670	Belongs to the BI1 family
AM488_19695	COG2200	EAL domain
AM488_19700	COG2200	EAL domain
AM488_19710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM488_19715	COG1012	belongs to the aldehyde dehydrogenase family
AM488_19720	COG4638	Rieske (2fe-2S)
AM488_19725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM488_19735	COG0473	3-isopropylmalate dehydrogenase activity
AM488_19740	COG0583	DNA-binding transcription factor activity
AM488_19745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM488_19750	COG1012	belongs to the aldehyde dehydrogenase family
AM488_19755	COG1917	Cupin 2, conserved barrel domain protein
AM488_19755	COG1396	sequence-specific DNA binding
AM488_19760	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AM488_19765	COG0174	glutamine synthetase
AM488_19775	COG0531	amino acid
AM488_19790	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_19795	COG1733	regulation of RNA biosynthetic process
AM488_19815	COG3729	General stress protein
AM488_19825	COG2233	PERMEase
AM488_19860	COG1309	transcriptional regulator
AM488_19880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM488_19890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AM488_19895	COG0672	)-iron permease
AM488_19910	COG1702	phosphate starvation-inducible protein PhoH
AM488_19930	COG1335	isochorismatase
AM488_19940	COG0583	DNA-binding transcription factor activity
AM488_19975	COG3381	protein complex oligomerization
AM488_20015	COG5645	(Lipo)protein
AM488_20035	COG1560	Kdo2-lipid A biosynthetic process
AM488_20085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM488_20105	COG2814	Major facilitator Superfamily
AM488_20110	COG0583	DNA-binding transcription factor activity
AM488_20115	COG1530	ribonuclease E activity
AM488_20135	COG1399	metal-binding, possibly nucleic acid-binding protein
AM488_20155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AM488_20160	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_20170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM488_20175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AM488_20180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AM488_20190	COG0470	DNA polymerase III
AM488_20195	COG0084	hydrolase, TatD family'
AM488_20205	COG0537	adenosine 5'-monophosphoramidase activity
AM488_20210	COG5633	Lipoprotein
AM488_20235	COG1252	NADH dehydrogenase
AM488_20240	COG3134	Outer membrane lipoprotein
AM488_20250	COG1309	transcriptional regulator
AM488_20260	COG1388	LysM domain
AM488_20260	COG1376	ErfK ybiS ycfS ynhG family protein
AM488_20265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AM488_20270	COG4591	ABC-type transport system involved in lipoprotein release permease component
AM488_20280	COG4591	ABC-type transport system involved in lipoprotein release permease component
AM488_20290	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AM488_20300	COG0318	PFAM AMP-dependent synthetase and ligase
AM488_20310	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AM488_20315	COG1177	transmembrane transport
AM488_20320	COG1176	ABC-type spermidine putrescine transport system, permease component I
AM488_20335	COG2850	peptidyl-arginine hydroxylation
AM488_20340	COG2205	protein histidine kinase activity
AM488_20360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AM488_20380	COG1187	pseudouridine synthase activity
AM488_20385	COG0538	isocitrate dehydrogenase activity
AM488_20390	COG0640	Transcriptional regulator
AM488_20405	COG3813	Protein conserved in bacteria
AM488_20410	COG1063	alcohol dehydrogenase
AM488_20415	COG3729	General stress protein
AM488_20420	COG3685	Protein conserved in bacteria
AM488_20425	COG3685	Protein conserved in bacteria
AM488_20430	COG3546	catalase activity
AM488_20435	COG1271	oxidase subunit
AM488_20440	COG1294	oxidase, subunit
AM488_20465	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AM488_20470	COG0583	DNA-binding transcription factor activity
AM488_20475	COG3706	GGDEF domain
AM488_20480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AM488_20495	COG1560	Kdo2-lipid A biosynthetic process
AM488_20505	COG3182	Iron-regulated membrane protein
AM488_20525	COG2203	Gaf domain
AM488_20525	COG2199	diguanylate cyclase activity
AM488_20530	COG3042	response to heat
AM488_20535	COG3189	MarR family transcriptional regulator
AM488_20540	COG1683	Conserved Protein
AM488_20545	COG0504	CTP synthase activity
AM488_20550	COG2807	transmembrane transport
AM488_20555	COG2207	Transcriptional regulator
AM488_20565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AM488_20570	COG0859	PFAM glycosyl transferase family 9
AM488_20585	COG3344	reverse transcriptase
AM488_20590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AM488_20595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM488_20600	COG0583	DNA-binding transcription factor activity
AM488_20605	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_20625	COG0386	Belongs to the glutathione peroxidase family
AM488_20640	COG2766	serine protein kinase
AM488_20645	COG3713	MltA-interacting MipA family protein
AM488_20650	COG0656	L-ascorbic acid biosynthetic process
AM488_20660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AM488_20670	COG3139	Protein of unknown function (DUF1315)
AM488_20675	COG1403	HNH endonuclease
AM488_20685	COG1063	alcohol dehydrogenase
AM488_20690	COG2271	Major facilitator Superfamily
AM488_20695	COG1063	alcohol dehydrogenase
AM488_20700	COG0191	fructose-bisphosphate aldolase activity
AM488_20705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM488_20710	COG0667	Aldo Keto reductase
AM488_20715	COG1349	DNA-binding transcription factor activity
AM488_20720	COG2814	Major facilitator Superfamily
AM488_20725	COG1335	isochorismatase
AM488_20730	COG0252	asparaginase activity
AM488_20735	COG0616	signal peptide processing
AM488_20740	COG0778	Nitroreductase
AM488_20760	COG0709	Synthesizes selenophosphate from selenide and ATP
AM488_20765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AM488_20775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AM488_20780	COG0494	nUDIX hydrolase
AM488_20785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AM488_20790	COG2897	thiosulfate sulfurtransferase activity
AM488_20795	COG4136	ATPase activity
AM488_20800	COG4135	transport system, permease component
AM488_20805	COG4134	Bacterial extracellular solute-binding protein
AM488_20810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM488_20815	COG0398	Pfam SNARE associated Golgi protein
AM488_20820	COG0398	Pfam SNARE associated Golgi protein
AM488_20825	COG0708	Exodeoxyribonuclease III
AM488_20835	COG3138	arginine N-succinyltransferase
AM488_20845	COG3724	N-succinylarginine dihydrolase activity
AM488_20855	COG3678	ATP-independent chaperone mediated protein folding
AM488_20860	COG0322	excinuclease ABC activity
AM488_20870	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM488_20875	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM488_20880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM488_20885	COG1447	Phosphotransferase system cellobiose-specific component IIA
AM488_20890	COG2169	Transcriptional regulator
AM488_20890	COG1917	Cupin 2, conserved barrel domain protein
AM488_20895	COG1486	melibiose metabolic process
AM488_20905	COG0753	catalase activity
AM488_20920	COG1988	membrane-bound metal-dependent
AM488_20925	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_20930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM488_20940	COG1607	acyl-coa hydrolase
AM488_20965	COG3047	cAMP biosynthetic process
AM488_20975	COG4774	siderophore transport
AM488_21030	COG0134	indole-3-glycerol-phosphate synthase activity
AM488_21030	COG0135	phosphoribosylanthranilate isomerase activity
AM488_21035	COG0512	Glutamine amidotransferase of anthranilate synthase
AM488_21035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AM488_21040	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AM488_21050	COG0009	L-threonylcarbamoyladenylate synthase
AM488_21060	COG0583	DNA-binding transcription factor activity
AM488_21065	COG1187	pseudouridine synthase activity
AM488_21070	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AM488_21075	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_21085	COG0616	signal peptide processing
AM488_21100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AM488_21120	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AM488_21130	COG0671	phosphoesterase, PA-phosphatase related
AM488_21135	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AM488_21140	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AM488_21150	COG0023	Translation Initiation Factor
AM488_21160	COG1349	DNA-binding transcription factor activity
AM488_21175	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM488_21175	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM488_21180	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AM488_21190	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AM488_21205	COG4171	peptide transport system, permease
AM488_21230	COG3316	Transposase and inactivated derivatives
AM488_21270	COG3316	Transposase and inactivated derivatives
AM488_21280	COG3316	Transposase and inactivated derivatives
AM488_21305	COG3344	reverse transcriptase
AM488_21310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AM488_21315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM488_21325	COG2135	peptidase activity
AM488_21330	COG4168	peptide transport system, permease
AM488_21340	COG0702	epimerase
AM488_21355	COG1473	amidohydrolase
AM488_21365	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AM488_21370	COG1842	Phage shock protein A
AM488_21380	COG1983	PspC domain protein
AM488_21390	COG3106	COG3106 Predicted ATPase
AM488_21400	COG0583	DNA-binding transcription factor activity
AM488_21405	COG1486	melibiose metabolic process
AM488_21410	COG3283	Transcriptional regulator of aromatic amino acids metabolism
AM488_21415	COG3180	Ammonia monooxygenase
AM488_21420	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AM488_21425	COG4948	Mandelate Racemase Muconate Lactonizing
AM488_21430	COG2866	Carboxypeptidase
AM488_21435	COG4166	transmembrane transport
AM488_21465	COG0656	L-ascorbic acid biosynthetic process
AM488_21485	COG0583	DNA-binding transcription factor activity
AM488_21490	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_21495	COG1078	dGTPase activity
AM488_21500	COG0693	protein deglycase activity
AM488_21505	COG0582	viral genome integration into host DNA
AM488_21605	COG0484	heat shock protein binding
AM488_21615	COG3772	lysozyme
AM488_21635	COG1783	phage Terminase large subunit
AM488_21640	COG3567	Phage-associated protein, HI1409 family
AM488_21710	COG1196	nuclear chromosome segregation
AM488_21710	COG0741	lytic transglycosylase activity
AM488_21710	COG0739	heme binding
AM488_21800	COG3344	reverse transcriptase
AM488_21820	COG0582	viral genome integration into host DNA
AM488_21920	COG0484	heat shock protein binding
AM488_21930	COG3772	lysozyme
AM488_21950	COG1783	phage Terminase large subunit
AM488_21955	COG3567	Phage-associated protein, HI1409 family
AM488_22025	COG0739	heme binding
AM488_22025	COG1196	nuclear chromosome segregation
AM488_22025	COG0741	lytic transglycosylase activity
AM488_22115	COG3344	reverse transcriptase
AM488_22155	COG2885	chlorophyll binding
AM488_22255	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_22260	COG1309	transcriptional regulator
AM488_22265	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_22285	COG0583	DNA-binding transcription factor activity
AM488_22315	COG0436	Aminotransferase
AM488_22330	COG2011	ABC-type metal ion transport system permease component
AM488_22335	COG1448	Aminotransferase
AM488_22345	COG1522	sequence-specific DNA binding
AM488_22350	COG1113	amino acid transport
AM488_22365	COG0673	inositol 2-dehydrogenase activity
AM488_22370	COG1349	DNA-binding transcription factor activity
AM488_22390	COG0513	Belongs to the DEAD box helicase family
AM488_22400	COG0589	response to stress
AM488_22410	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM488_22415	COG1013	pyruvate-flavodoxin oxidoreductase activity
AM488_22415	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM488_22415	COG0674	pyruvate-flavodoxin oxidoreductase activity
AM488_22415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AM488_22425	COG3042	response to heat
AM488_22430	COG3187	Heat shock protein
AM488_22435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AM488_22440	COG0586	Pfam SNARE associated Golgi protein
AM488_22445	COG2911	Protein conserved in bacteria
AM488_22455	COG3784	Protein of unknown function (DUF1318)
AM488_22460	COG2207	Transcriptional regulator
AM488_22465	COG1012	belongs to the aldehyde dehydrogenase family
AM488_22495	COG2030	dehydratase
AM488_22495	COG1012	belongs to the aldehyde dehydrogenase family
AM488_22500	COG3396	Phenylacetate-CoA oxygenase
AM488_22505	COG3460	Phenylacetate-CoA oxygenase
AM488_22510	COG3396	Phenylacetate-CoA oxygenase
AM488_22515	COG2151	metal-sulfur cluster biosynthetic enzyme
AM488_22520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM488_22525	COG1024	Enoyl-CoA hydratase
AM488_22530	COG1024	Enoyl-CoA hydratase
AM488_22535	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM488_22540	COG2050	protein possibly involved in aromatic compounds catabolism
AM488_22545	COG0183	Belongs to the thiolase family
AM488_22550	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AM488_22555	COG3327	negative regulation of DNA-templated transcription, initiation
AM488_22560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM488_22575	COG1643	Atp-dependent helicase
AM488_22585	COG1538	Outer membrane efflux protein
AM488_22605	COG0583	DNA-binding transcription factor activity
AM488_22610	COG0667	Aldo Keto reductase
AM488_22615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AM488_22620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM488_22625	COG3138	arginine N-succinyltransferase
AM488_22630	COG1012	belongs to the aldehyde dehydrogenase family
AM488_22635	COG3724	N-succinylarginine dihydrolase activity
AM488_22640	COG2988	succinylglutamate desuccinylase activity
AM488_22645	COG1113	amino acid transport
AM488_22650	COG0477	Major facilitator Superfamily
AM488_22655	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AM488_22660	COG1012	belongs to the aldehyde dehydrogenase family
AM488_22665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AM488_22670	COG0401	homolog of Blt101
AM488_22675	COG5562	phage envelope protein
AM488_22680	COG0425	Belongs to the sulfur carrier protein TusA family
AM488_22685	COG2391	methyltransferase activity
AM488_22710	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AM488_22715	COG1263	PTS System
AM488_22715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM488_22720	COG1609	Transcriptional regulator
AM488_22725	COG5339	Protein conserved in bacteria
AM488_22730	COG1482	cell wall glycoprotein biosynthetic process
AM488_22735	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AM488_22735	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AM488_22740	COG0114	fumarate hydratase activity
AM488_22750	COG2205	protein histidine kinase activity
AM488_22760	COG0745	RESPONSE REGULATOR receiver
AM488_22765	COG3136	membrane protein required for alginate biosynthesis
AM488_22775	COG0531	amino acid
AM488_22795	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AM488_22800	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AM488_22815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM488_22820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM488_22830	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AM488_22835	COG1473	amidohydrolase
AM488_22845	COG0583	DNA-binding transcription factor activity
AM488_22850	COG2840	Smr protein MutS2
AM488_22855	COG1414	Transcriptional regulator
AM488_22865	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM488_22870	COG0183	Belongs to the thiolase family
AM488_22880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM488_22885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM488_22905	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AM488_22905	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AM488_22920	COG1053	succinate dehydrogenase
AM488_22930	COG4565	transcriptional regulatory protein
AM488_22935	COG3290	protein histidine kinase activity
AM488_22960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AM488_22970	COG0679	Auxin Efflux Carrier
AM488_23000	COG0628	permease
AM488_23020	COG3591	Belongs to the peptidase S1B family
AM488_23030	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AM488_23035	COG2814	Major facilitator Superfamily
AM488_23040	COG0583	DNA-binding transcription factor activity
AM488_23045	COG1940	carbohydrate kinase activity
AM488_23050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AM488_23065	COG3302	dmso reductase anchor subunit
AM488_23070	COG0437	4 iron, 4 sulfur cluster binding
AM488_23075	COG0243	molybdopterin cofactor binding
AM488_23090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM488_23105	COG2271	Major facilitator Superfamily
AM488_23110	COG0246	Mannitol dehydrogenase
AM488_23115	COG0589	response to stress
AM488_23120	COG1802	Transcriptional regulator
AM488_23125	COG4221	oxidoreductase activity
AM488_23140	COG2207	Transcriptional regulator
AM488_23145	COG2135	peptidase activity
AM488_23150	COG2197	response regulator
AM488_23160	COG0071	Belongs to the small heat shock protein (HSP20) family
AM488_23165	COG1546	Belongs to the CinA family
AM488_23170	COG2200	EAL domain
AM488_23185	COG3708	Transcriptional regulator
AM488_23185	COG2207	Transcriptional regulator
AM488_23190	COG2610	gluconate transmembrane transporter activity
AM488_23195	COG3622	Belongs to the hyi family
AM488_23200	COG0235	Class ii aldolase
AM488_23205	COG3395	kinase activity
AM488_23210	COG2084	Dehydrogenase
AM488_23215	COG1349	DNA-binding transcription factor activity
AM488_23230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AM488_23235	COG2223	nitrite transmembrane transporter activity
AM488_23270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AM488_23275	COG0683	leucine binding
AM488_23280	COG0559	Belongs to the binding-protein-dependent transport system permease family
AM488_23290	COG1129	ABC transporter
AM488_23295	COG0410	ABC transporter
AM488_23305	COG2814	Major facilitator Superfamily
AM488_23310	COG0697	spore germination
AM488_23320	COG4977	sequence-specific DNA binding
AM488_23325	COG1846	Transcriptional regulator
AM488_23345	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_23350	COG2731	YhcH YjgK YiaL family protein
AM488_23365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM488_23375	COG3395	kinase activity
AM488_23380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AM488_23385	COG1349	DNA-binding transcription factor activity
AM488_23390	COG0039	L-malate dehydrogenase activity
AM488_23400	COG0583	DNA-binding transcription factor activity
AM488_23405	COG1012	belongs to the aldehyde dehydrogenase family
AM488_23420	COG2199	diguanylate cyclase activity
AM488_23485	COG0477	Major facilitator Superfamily
AM488_23500	COG0477	Major facilitator Superfamily
AM488_23510	COG2070	2-Nitropropane dioxygenase
AM488_23515	COG2011	ABC-type metal ion transport system permease component
AM488_23535	COG4628	conserved protein (DUF2132)
AM488_23550	COG2207	Transcriptional regulator
AM488_23580	COG2233	PERMEase
AM488_23585	COG3648	Uricase
AM488_23585	COG3195	allantoin biosynthetic process
AM488_23590	COG2351	hydroxyisourate hydrolase activity
AM488_23595	COG1396	sequence-specific DNA binding
AM488_23600	COG3550	peptidyl-serine autophosphorylation
AM488_23615	COG3188	usher protein
AM488_23635	COG0024	Methionine aminopeptidase
AM488_23650	COG3300	MHYT domain
AM488_23650	COG5001	Diguanylate cyclase
AM488_23655	COG2819	hydrolase of the alpha beta superfamily
AM488_23670	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_23670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_23675	COG2814	Major facilitator Superfamily
AM488_23690	COG1263	PTS System
AM488_23690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM488_23695	COG2186	Transcriptional regulator
AM488_23715	COG3835	regulator
AM488_23720	COG1929	Belongs to the glycerate kinase type-1 family
AM488_23765	COG0738	Major facilitator superfamily
AM488_23770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM488_23775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AM488_23785	COG4977	sequence-specific DNA binding
AM488_23800	COG0667	Aldo Keto reductase
AM488_23810	COG0667	Aldo Keto reductase
AM488_23815	COG0667	Aldo Keto reductase
AM488_23825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AM488_23825	COG0456	acetyltransferase
AM488_23840	COG1840	ABC-type Fe3 transport system, periplasmic component
AM488_23855	COG0426	domain, Protein
AM488_23855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM488_23870	COG1652	LysM domain
AM488_23900	COG1609	Transcriptional regulator
AM488_23910	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM488_23925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AM488_23935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM488_23940	COG0583	DNA-binding transcription factor activity
AM488_23945	COG0583	DNA-binding transcription factor activity
AM488_23960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM488_23960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM488_23960	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AM488_23965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM488_23975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AM488_23980	COG3037	sugar-specific permease SgaT UlaA
AM488_23990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM488_23995	COG1609	Transcriptional regulator
AM488_24005	COG2223	nitrite transmembrane transporter activity
AM488_24035	COG0477	Major facilitator Superfamily
AM488_24040	COG4529	Protein conserved in bacteria
AM488_24045	COG1902	pentaerythritol trinitrate reductase activity
AM488_24055	COG0583	DNA-binding transcription factor activity
AM488_24060	COG2070	2-Nitropropane dioxygenase
AM488_24070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AM488_24145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM488_24185	COG1335	isochorismatase
AM488_24195	COG0406	alpha-ribazole phosphatase activity
AM488_24230	COG1953	Uracil, thiamine, allantoin
AM488_24235	COG0402	S-adenosylhomocysteine deaminase activity
AM488_24240	COG3706	GGDEF domain
AM488_24255	COG0673	inositol 2-dehydrogenase activity
AM488_24265	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AM488_24270	COG1116	anion transmembrane transporter activity
AM488_24275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM488_24280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM488_24285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM488_24290	COG0076	glutamate decarboxylase activity
AM488_24305	COG2205	protein histidine kinase activity
AM488_24310	COG0745	RESPONSE REGULATOR receiver
AM488_24315	COG0596	Alpha beta hydrolase
AM488_24355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AM488_24355	COG0519	Catalyzes the synthesis of GMP from XMP
AM488_24375	COG0583	DNA-binding transcription factor activity
AM488_24385	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AM488_24390	COG1285	pathogenesis
AM488_24400	COG2814	Major facilitator Superfamily
AM488_24405	COG1447	Phosphotransferase system cellobiose-specific component IIA
AM488_24410	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM488_24435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM488_24440	COG0583	DNA-binding transcription factor activity
AM488_24445	COG0243	molybdopterin cofactor binding
AM488_24450	COG3781	membrane
AM488_24475	COG1764	response to oxidative stress
AM488_24480	COG3111	PFAM Bacterial OB fold (BOF) protein
AM488_24490	COG2323	membrane
AM488_24500	COG0366	Alpha amylase catalytic
AM488_24510	COG3685	Protein conserved in bacteria
AM488_24525	COG3729	General stress protein
AM488_24530	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_24570	COG0488	(ABC) transporter
AM488_24585	COG1064	alcohol dehydrogenase
AM488_24590	COG0747	negative chemotaxis
AM488_24610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM488_24620	COG2814	Major facilitator Superfamily
AM488_24630	COG2326	polyphosphate kinase activity
AM488_24645	COG2864	formate dehydrogenase
AM488_24650	COG0437	4 iron, 4 sulfur cluster binding
AM488_24675	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AM488_24685	COG3485	protocatechuate 3,4-dioxygenase
AM488_24690	COG4829	muconolactone delta-isomerase
AM488_24695	COG4948	Mandelate Racemase Muconate Lactonizing
AM488_24700	COG1414	Transcriptional regulator
AM488_24720	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AM488_24725	COG1140	nitrate reductase beta subunit
AM488_24730	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AM488_24735	COG2181	nitrate reductase activity
AM488_24740	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AM488_24745	COG1178	ABC-type Fe3 transport system permease component
AM488_24750	COG1840	ABC-type Fe3 transport system, periplasmic component
AM488_24755	COG3842	ATPase activity
AM488_24760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM488_24775	COG2211	Major facilitator Superfamily
AM488_24805	COG0625	glutathione transferase activity
AM488_24815	COG1126	abc transporter atp-binding protein
AM488_24820	COG0765	amino acid transport
AM488_24835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM488_24845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM488_24875	COG4772	TonB-dependent receptor
AM488_24880	COG1228	amidohydrolase
AM488_24885	COG3691	Protein conserved in bacteria
AM488_24900	COG2130	NADP-dependent
AM488_24910	COG1247	-acetyltransferase
AM488_24915	COG3238	Protein conserved in bacteria
AM488_24925	COG0747	negative chemotaxis
AM488_24930	COG1012	belongs to the aldehyde dehydrogenase family
AM488_24960	COG1012	belongs to the aldehyde dehydrogenase family
AM488_24965	COG1177	transmembrane transport
AM488_24970	COG1176	ABC-type spermidine putrescine transport system, permease component I
AM488_24975	COG3842	ATPase activity
AM488_24980	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AM488_24985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM488_24990	COG1271	oxidase subunit
AM488_24995	COG1294	oxidase, subunit
AM488_25015	COG0826	peptidase U32
AM488_25025	COG1396	sequence-specific DNA binding
AM488_25030	COG3135	benzoate transporter
AM488_25035	COG3708	Transcriptional regulator
AM488_25035	COG2207	Transcriptional regulator
AM488_25050	COG0500	methyltransferase
AM488_25055	COG1275	C4-dicarboxylate transporter malic acid transport protein
AM488_25060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM488_25065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM488_25080	COG2272	Belongs to the type-B carboxylesterase lipase family
AM488_25085	COG5383	Protein conserved in bacteria
AM488_25090	COG3485	protocatechuate 3,4-dioxygenase
AM488_25095	COG3485	protocatechuate 3,4-dioxygenase
AM488_25100	COG0583	DNA-binding transcription factor activity
AM488_25120	COG3038	cytochrome b561
AM488_25135	COG1733	regulation of RNA biosynthetic process
AM488_25140	COG2814	Major facilitator Superfamily
AM488_25150	COG0673	inositol 2-dehydrogenase activity
AM488_25160	COG2723	6-phospho-beta-galactosidase activity
AM488_25195	COG4659	FMN binding
AM488_25205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AM488_25220	COG0625	glutathione transferase activity
AM488_25225	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AM488_25240	COG3895	Periplasmic Protein
AM488_25250	COG3133	Outer membrane lipoprotein
AM488_25255	COG3706	GGDEF domain
AM488_25270	COG1566	PFAM secretion protein HlyD family protein
AM488_25275	COG1289	transmembrane transporter activity
AM488_25280	COG2032	superoxide dismutase activity
AM488_25285	COG4989	oxidoreductase activity
AM488_25290	COG3313	Fe-S protein
AM488_25295	COG1309	transcriptional regulator
AM488_25300	COG1902	pentaerythritol trinitrate reductase activity
AM488_25305	COG0346	lactoylglutathione lyase activity
AM488_25315	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AM488_25320	COG0791	NLP P60 protein
AM488_25330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AM488_25335	COG2814	Major facilitator Superfamily
AM488_25350	COG0583	DNA-binding transcription factor activity
AM488_25355	COG2814	Major facilitator Superfamily
AM488_25360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AM488_25365	COG0307	riboflavin synthase, alpha
AM488_25435	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AM488_25465	COG1349	DNA-binding transcription factor activity
AM488_25470	COG0346	lactoylglutathione lyase activity
AM488_25495	COG0444	Belongs to the ABC transporter superfamily
AM488_25500	COG4608	Belongs to the ABC transporter superfamily
AM488_25560	COG0583	DNA-binding transcription factor activity
AM488_25575	COG0402	S-adenosylhomocysteine deaminase activity
AM488_25600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM488_25605	COG0277	FAD linked oxidase domain protein
AM488_25630	COG0583	DNA-binding transcription factor activity
AM488_25640	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM488_25650	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM488_25655	COG2610	gluconate transmembrane transporter activity
AM488_25660	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_25695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM488_25715	COG0745	RESPONSE REGULATOR receiver
AM488_25720	COG3850	Histidine kinase
AM488_25720	COG5002	protein histidine kinase activity
AM488_25735	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AM488_25775	COG3088	subunit of a heme lyase
AM488_25775	COG4235	cytochrome complex assembly
AM488_25780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM488_25785	COG1138	Cytochrome C-type biogenesis protein
AM488_25800	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AM488_25805	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AM488_25810	COG4133	protoheme IX ABC transporter activity
AM488_25840	COG1175	transmembrane transport
AM488_25845	COG1840	ABC-type Fe3 transport system, periplasmic component
AM488_25855	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AM488_25860	COG3383	formate dehydrogenase (NAD+) activity
AM488_25865	COG1473	amidohydrolase
AM488_25880	COG2814	Major facilitator Superfamily
AM488_25895	COG1126	abc transporter atp-binding protein
AM488_25900	COG0765	amino acid transport
AM488_25920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM488_25925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM488_25930	COG1120	ATPase activity
AM488_25935	COG4774	siderophore transport
AM488_25940	COG1116	anion transmembrane transporter activity
AM488_25945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM488_25965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM488_25970	COG0583	DNA-binding transcription factor activity
AM488_25990	COG2814	Major facilitator Superfamily
AM488_26025	COG1414	Transcriptional regulator
AM488_26050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AM488_26055	COG2271	Major facilitator Superfamily
AM488_26065	COG1309	transcriptional regulator
AM488_26090	COG1376	ErfK ybiS ycfS ynhG family protein
AM488_26105	COG0719	Fe-S assembly protein
AM488_26110	COG0396	ATPase activity
AM488_26115	COG0719	Fe-S assembly protein
AM488_26120	COG0316	Belongs to the HesB IscA family
AM488_26135	COG1309	transcriptional regulator
AM488_26140	COG1304	FMN binding
AM488_26165	COG0583	DNA-binding transcription factor activity
AM488_26175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM488_26180	COG1120	ATPase activity
AM488_26210	COG2261	transglycosylase associated protein
AM488_26225	COG2050	protein possibly involved in aromatic compounds catabolism
AM488_26230	COG0277	FAD linked oxidase domain protein
AM488_26230	COG0247	lactate metabolic process
AM488_26235	COG0628	permease
AM488_26245	COG0574	Belongs to the PEP-utilizing enzyme family
AM488_26245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM488_26255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM488_26260	COG4256	Hemin uptake protein
AM488_26270	COG0791	NLP P60 protein
AM488_26280	COG0386	Belongs to the glutathione peroxidase family
AM488_26300	COG0583	DNA-binding transcription factor activity
AM488_26320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM488_26320	COG0072	phenylalanine-tRNA ligase activity
AM488_26360	COG3137	Salt-induced outer membrane protein
AM488_26365	COG1105	Belongs to the carbohydrate kinase PfkB family
AM488_26385	COG2350	Protein conserved in bacteria
AM488_26390	COG2353	YceI-like domain
AM488_26410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM488_26420	COG0444	Belongs to the ABC transporter superfamily
AM488_26425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM488_26430	COG0601	transmembrane transport
AM488_26435	COG4166	transmembrane transport
AM488_26440	COG2095	MarC family integral membrane protein
AM488_26450	COG1454	alcohol dehydrogenase
AM488_26450	COG1012	belongs to the aldehyde dehydrogenase family
AM488_26455	COG1435	thymidine kinase activity
AM488_26460	COG2916	Histone family protein nucleoid-structuring protein H-NS
AM488_26465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AM488_26470	COG0745	RESPONSE REGULATOR receiver
AM488_26475	COG1752	Esterase of the alpha-beta hydrolase superfamily
AM488_26485	COG0788	formyltetrahydrofolate deformylase activity
AM488_26515	COG1522	sequence-specific DNA binding
AM488_26525	COG2181	nitrate reductase activity
AM488_26530	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AM488_26535	COG1140	nitrate reductase beta subunit
AM488_26540	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AM488_26545	COG2223	nitrite transmembrane transporter activity
AM488_26550	COG3850	Histidine kinase
AM488_26555	COG2197	response regulator
AM488_26560	COG4932	domain protein
AM488_26565	COG0243	molybdopterin cofactor binding
AM488_26570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM488_26570	COG2146	nitrite reductase [NAD(P)H] activity
AM488_26575	COG1116	anion transmembrane transporter activity
AM488_26585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM488_26590	COG3707	response regulator
AM488_26595	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AM488_26605	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AM488_26610	COG4572	Cation transport regulator
AM488_26615	COG0387	Pfam Sodium calcium exchanger
AM488_26625	COG2912	Transglutaminase-like superfamily
AM488_26630	COG3094	Invasion gene expression up-regulator, SirB
AM488_26635	COG2890	protein-(glutamine-N5) methyltransferase activity
AM488_26665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AM488_26670	COG0659	secondary active sulfate transmembrane transporter activity
AM488_26690	COG0012	GTP binding
AM488_26770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM488_26835	COG3501	Rhs element vgr protein
AM488_26840	COG2885	chlorophyll binding
AM488_26865	COG3122	Protein conserved in bacteria
AM488_26880	COG0583	DNA-binding transcription factor activity
AM488_26910	COG0583	DNA-binding transcription factor activity
AM488_26915	COG0410	ABC transporter
AM488_26930	COG0559	Belongs to the binding-protein-dependent transport system permease family
AM488_26940	COG1882	Formate acetyltransferase
AM488_26955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM488_26960	COG0583	DNA-binding transcription factor activity
AM488_27000	COG2308	Evidence 4 Homologs of previously reported genes of
AM488_27015	COG4774	siderophore transport
AM488_27025	COG1619	proteins homologs of microcin C7 resistance protein MccF
AM488_27065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM488_27125	COG2801	Transposase and inactivated derivatives
AM488_27135	COG2801	Transposase and inactivated derivatives
AM488_27165	COG2916	Histone family protein nucleoid-structuring protein H-NS
AM488_27275	COG1358	cellular component organization or biogenesis
AM488_27295	COG4245	von Willebrand factor, type A
AM488_27305	COG4245	von Willebrand factor, type A
AM488_27310	COG4245	von Willebrand factor, type A
AM488_27330	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
AM488_27340	COG3436	PFAM IS66 Orf2 family protein
AM488_27345	COG4372	Transposase
AM488_27360	COG3436	PFAM IS66 Orf2 family protein
AM488_27365	COG4372	Transposase
AM488_27450	COG1028	Short-chain dehydrogenase reductase Sdr
AM488_27455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AM488_27460	COG1902	pentaerythritol trinitrate reductase activity
AM488_27500	COG3316	Transposase and inactivated derivatives
AM488_27540	COG3316	Transposase and inactivated derivatives
AM488_27615	COG3188	usher protein
AM488_27700	COG1484	DNA-dependent DNA replication
AM488_27705	COG4584	PFAM Integrase catalytic
AM488_27720	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
AM488_27780	COG3344	reverse transcriptase
AM488_27880	COG0210	DNA helicase
AM488_28175	COG1484	DNA-dependent DNA replication
AM488_28210	COG0633	Ferredoxin
AM488_28255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM488_28265	COG3414	Phosphotransferase system galactitol-specific IIB component
AM488_28270	COG3775	system Galactitol-specific IIC component
AM488_28285	COG2376	Dihydroxyacetone kinase
AM488_28305	COG1461	Dihydroxyacetone kinase
AM488_28310	COG2376	Dihydroxyacetone kinase
AM488_28315	COG0583	DNA-binding transcription factor activity
AM488_28535	COG3344	reverse transcriptase
AM488_28590	COG2801	Transposase and inactivated derivatives
AM488_28600	COG3111	PFAM Bacterial OB fold (BOF) protein
AM488_28615	COG2814	Major facilitator Superfamily
AM488_28665	COG3077	Addiction module antitoxin, RelB DinJ family
AM488_28670	COG2026	Addiction module toxin, RelE StbE family
AM488_29025	COG5499	transcription regulator containing HTH domain
AM488_29105	COG1475	DNA binding
AM488_29180	COG3344	reverse transcriptase
AM488_29220	COG1475	DNA binding
AM488_29225	COG1192	Involved in chromosome partitioning
AM488_29245	COG2199	diguanylate cyclase activity
AM488_29245	COG2203	Gaf domain
AM488_29250	COG5001	Diguanylate cyclase
AM488_29250	COG1716	ATPase activity
AM488_29270	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AM488_29275	COG4325	translation initiation factor activity
AM488_29280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM488_29330	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM488_29360	COG0739	heme binding
AM488_29370	COG2132	Multicopper oxidase
AM488_29375	COG3667	copper resistance
AM488_29380	COG2372	response to copper ion
AM488_29385	COG1276	copper resistance
AM488_29390	COG0745	RESPONSE REGULATOR receiver
AM488_29395	COG2205	protein histidine kinase activity
AM488_29415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AM488_29430	COG0431	NADPH-dependent FMN reductase
AM488_29460	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AM488_29525	COG2801	Transposase and inactivated derivatives
AM488_29535	COG0501	Belongs to the peptidase M48B family
AM488_29555	COG0542	response to heat
AM488_29560	COG0071	Belongs to the small heat shock protein (HSP20) family
AM488_29585	COG3039	Transposase
AM488_29635	COG3316	Transposase and inactivated derivatives
AM488_29655	COG1609	Transcriptional regulator
AM488_29665	COG2223	nitrite transmembrane transporter activity
AM488_29755	COG3736	Type IV secretory pathway, component VirB8
AM488_29820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AM488_29825	COG0484	heat shock protein binding
AM488_29940	COG5002	protein histidine kinase activity
AM488_29940	COG2198	Histidine kinase
AM488_29940	COG0784	Response regulator, receiver
AM488_30005	COG3549	Plasmid maintenance system killer
AM488_30010	COG3093	addiction module antidote protein HigA
AM488_30055	COG3316	Transposase and inactivated derivatives
AM488_30095	COG3316	Transposase and inactivated derivatives
AM488_30115	COG1192	Involved in chromosome partitioning
AM488_30140	COG3344	reverse transcriptase
AM488_30170	COG3316	Transposase and inactivated derivatives
AM488_30235	COG3316	Transposase and inactivated derivatives
AM488_30255	COG3316	Transposase and inactivated derivatives
AM488_30300	COG1660	Displays ATPase and GTPase activities
AM488_30345	COG3316	Transposase and inactivated derivatives
AM488_30355	COG1660	Displays ATPase and GTPase activities
AM488_30365	COG3316	Transposase and inactivated derivatives
AM488_30385	COG3316	Transposase and inactivated derivatives
AM488_30400	COG4644	lycopene metabolic process
AM488_30425	COG3316	Transposase and inactivated derivatives
AM488_30500	COG3316	Transposase and inactivated derivatives
AM488_30540	COG3316	Transposase and inactivated derivatives