locus-tag class description CSC00_0001 ENOG4108C33 Resolvase CSC00_0016 ENOG4105F2I Transposase CSC00_0033 ENOG4108TFU terminase (Small subunit) CSC00_0064 ENOG4108EU3 peptide transport system, permease CSC00_0065 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein CSC00_0066 ENOG4108JQ2 peptide transport system atp-binding protein CSC00_0067 ENOG4105ETS cytosine purines uracil thiamine allantoin CSC00_0070 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CSC00_0072 ENOG4105Q4T oxidoreductase CSC00_0073 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) CSC00_0075 ENOG4105N2W Transcriptional regulator CSC00_0077 ENOG41061RM osmotically inducible lipoprotein CSC00_0078 ENOG4108ZJT translation initiation factor, Sui1 CSC00_0080 ENOG4105CFV Tetratricopeptide repeat protein CSC00_0081 ENOG4105Q4A inner membrane protein yciS CSC00_0082 ENOG4105EYK Phosphatidylglycerophosphatase B CSC00_0083 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) CSC00_0084 ENOG4107QM5 aconitate hydratase CSC00_0087 ENOG4107R11 Transcriptional regulator CSC00_0089 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CSC00_0092 ENOG4105RKX Protein of unknown function (DUF2498) CSC00_0093 ENOG4105ERU peptidase CSC00_0095 ENOG4105UBK short-chain dehydrogenase reductase CSC00_0096 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CSC00_0097 ENOG4105FE9 pseudouridine synthase CSC00_0098 ENOG4105ETT transcriptional Regulator, LysR family CSC00_0100 ENOG4107RTD sua5 ycio yrdc ywlc family protein CSC00_0101 ENOG4105DB7 PHP domain protein CSC00_0102 ENOG4105CRQ synthase (Component I) CSC00_0103 ENOG4108EFP Anthranilate synthase component II CSC00_0104 ENOG4105DK0 Indole-3-glycerol phosphate synthase CSC00_0105 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CSC00_0115 ENOG4108IU3 tonb-dependent siderophore receptor CSC00_0116 ENOG4107E2E PKHD-type hydroxylase CSC00_0117 ENOG4105EIF outer membrane protein W CSC00_0118 ENOG4105PI0 Ferredoxin CSC00_0119 ENOG4108S3I UPF0259 membrane protein CSC00_0120 ENOG4107835 probably involved in intracellular septation (By similarity) CSC00_0121 ENOG4107RNH Outer membrane receptor FepA CSC00_0122 ENOG4105NAU thioesterase Superfamily protein CSC00_0123 ENOG4107PN8 YfeABCD locus regulator CSC00_0124 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 CSC00_0125 ENOG4105CHR reductase CSC00_0126 ENOG4107K5X Membrane-bound metal-dependent hydrolase CSC00_0127 ENOG4108ETY sodium dicarboxylate symporter CSC00_0128 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) CSC00_0129 ENOG4105CH6 catalase CSC00_0130 ENOG410901P UPF0249 protein CSC00_0131 ENOG4105F8D glycoside hydrolase family 4 CSC00_0132 ENOG4105EZV Transcriptional regulator CSC00_0133 ENOG4105VCP PTS System CSC00_0134 ENOG4105CK1 PTS System CSC00_0136 ENOG4105VZJ PTS System CSC00_0137 ENOG4105KKI DNA-binding transcriptional activator OsmE CSC00_0139 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) CSC00_0140 ENOG4108SPG Periplasmic Protein CSC00_0143 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) CSC00_0144 ENOG4105C26 Dehydrogenase CSC00_0145 ENOG4105F4X arginine CSC00_0147 ENOG4105CGK Exodeoxyribonuclease III CSC00_0148 ENOG4108RSN SNARE associated Golgi CSC00_0149 ENOG4108N5C SNARE associated Golgi protein-related protein CSC00_0150 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CSC00_0151 ENOG4105VNH ABC transporter solute-binding protein CSC00_0152 ENOG4105CXZ ABC transporter, permease CSC00_0153 ENOG4108VGW abc transporter atp-binding protein CSC00_0154 ENOG4107RM6 sulfurtransferase CSC00_0155 ENOG4108T9J Cdp-alcohol phosphatidyltransferase CSC00_0156 ENOG4105M6F mutator MutT protein CSC00_0157 ENOG4105D82 Glutamate dehydrogenase CSC00_0159 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CSC00_0160 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) CSC00_0161 ENOG4105SBG acid phosphatase CSC00_0162 ENOG4105DQ6 Transposase CSC00_0164 ENOG41069NU Nitroreductase CSC00_0165 ENOG4105D07 Signal peptide peptidase, SppA CSC00_0166 ENOG4105HDK L-asparaginase CSC00_0167 ENOG4108RWI nicotinamidase CSC00_0168 ENOG4108KUU Inner membrane metabolite transport protein ydjE CSC00_0169 ENOG4105E98 transcriptional regulator DeoR family CSC00_0170 ENOG4105CPC Aldo Keto reductase CSC00_0171 ENOG4107UH8 sugar kinase CSC00_0172 ENOG4105D2N Aldolase CSC00_0173 ENOG4105CPQ Dehydrogenase CSC00_0174 ENOG4107TE1 transport protein CSC00_0175 ENOG4105CPQ Dehydrogenase CSC00_0177 ENOG4105N1F Hnh endonuclease CSC00_0178 ENOG4105VUT cytoplasmic protein CSC00_0179 ENOG4105E0X reductase CSC00_0180 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CSC00_0181 ENOG4105DSB aldose 1-epimerase CSC00_0182 ENOG4105CV8 reductase CSC00_0183 ENOG4105GNX MltA-interacting MipA family protein CSC00_0184 ENOG4105CYN Serine protein kinase CSC00_0185 ENOG4106AKX UPF0229 protein CSC00_0187 ENOG4108V06 Glutathione peroxidase CSC00_0192 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CSC00_0193 ENOG4105CBN LysR family transcriptional regulator CSC00_0194 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CSC00_0195 ENOG4105KT5 UmuD protein CSC00_0196 ENOG4105EKQ RNA-directed DNA polymerase CSC00_0197 ENOG4105Y50 Virulence Protein CSC00_0198 ENOG4108XNZ glycosyl transferase CSC00_0200 ENOG4108KXH Ybak prolyl-tRNA synthetase associated CSC00_0201 ENOG4108VMM UPF0756 membrane protein CSC00_0202 ENOG4105R1U AraC Family Transcriptional Regulator CSC00_0203 ENOG4105DJ2 Major Facilitator Superfamily CSC00_0204 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CSC00_0205 ENOG4105EWC Purine nucleoside phosphorylase CSC00_0206 ENOG4105K78 MarR family Transcriptional regulator CSC00_0207 ENOG4105UCG Domain of unknown function (DUF333) CSC00_0208 ENOG410620I Diguanylate cyclase CSC00_0209 ENOG4106G4W CSC00_0211 ENOG4105S5I Membrane CSC00_0212 ENOG4108NIW Leucine export protein LeuE CSC00_0213 ENOG4105D1S lipid A biosynthesis CSC00_0216 ENOG4105DHT Metal Dependent Phosphohydrolase CSC00_0217 ENOG4106TD9 Diguanylate cyclase CSC00_0218 ENOG4107RSM transcriptional regulator CSC00_0219 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CSC00_0225 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CSC00_0226 ENOG4105C4M (Ubiquinol oxidase) subunit I CSC00_0227 ENOG4105WEF catalase CSC00_0228 ENOG4108N8X transition metal ion binding CSC00_0229 ENOG4108Z9Z response to DNA damage stimulus CSC00_0232 ENOG4105E2A Dehydrogenase CSC00_0233 ENOG4105XDF Protein of unknown function (DUF1272) CSC00_0236 ENOG4108ZHR arsR family transcriptional regulator CSC00_0237 ENOG4108HMX isocitrate dehydrogenase (NADP) CSC00_0240 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CSC00_0242 ENOG4107QTF adenylosuccinate lyase CSC00_0246 ENOG4105IFJ Histidine kinase CSC00_0247 ENOG4105EZE Cupin 4 family protein CSC00_0250 ENOG4105F38 ABC transporter, permease CSC00_0251 ENOG4105D38 putrescine abc transporter CSC00_0252 ENOG4107RUE extracellular solute-binding protein family 1 CSC00_0254 ENOG4105CEY Amp-dependent synthetase and ligase CSC00_0256 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CSC00_0257 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) CSC00_0258 ENOG4105D60 lipoprotein releasing system transmembrane protein CSC00_0259 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CSC00_0260 ENOG4105D60 lipoprotein releasing system transmembrane protein CSC00_0262 ENOG4108JA2 transcriptioN-repair coupling factor CSC00_0263 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CSC00_0264 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction CSC00_0266 ENOG4108IND Tetr family transcriptional regulator CSC00_0269 ENOG4107MBR 17 kDa surface antigen CSC00_0270 ENOG4105CEP NADH dehydrogenase CSC00_0271 ENOG4105D0Y UPF0227 protein CSC00_0274 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) CSC00_0275 ENOG41090DQ Lipoprotein CSC00_0276 ENOG4105K59 histidine triad (HIT) protein CSC00_0277 ENOG4105CI1 PTS System CSC00_0278 ENOG4105F8V Hydrolase, tatD family CSC00_0279 ENOG4107QRG dna polymerase iii CSC00_0280 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CSC00_0281 ENOG4105HHA aminodeoxychorismate lyase CSC00_0282 ENOG4105YAZ 4-amino-4-deoxychorismate lyase CSC00_0283 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CSC00_0284 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CSC00_0285 ENOG4105CHR reductase CSC00_0286 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CSC00_0287 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CSC00_0288 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CSC00_0290 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein CSC00_0291 ENOG4108UHJ MAF-like protein CSC00_0292 ENOG4105EI2 Pseudouridine synthase CSC00_0293 ENOG4107QQB Ribonuclease E CSC00_0294 ENOG4105CR8 Transcriptional regulator CSC00_0295 ENOG4105EQ0 Major Facilitator superfamily CSC00_0296 ENOG4105CJR Integral membrane protein (MviN CSC00_0297 ENOG4105EP9 oxidoreductase CSC00_0298 ENOG4108YXG UPF0502 protein CSC00_0299 ENOG4105D9U N-acetyltransferase CSC00_0300 ENOG4105EV4 Multidrug resistance protein mdtH CSC00_0301 ENOG4105F3T (LipO)protein CSC00_0303 ENOG4105EKE dihydroorotase CSC00_0304 ENOG4105MEA DNA damage-inducible protein i CSC00_0305 ENOG4105PVA Biofilm formation regulatory protein BssS CSC00_0307 ENOG4106974 biofilm formation CSC00_0310 ENOG4105D1S lipid A biosynthesis CSC00_0312 ENOG4108W47 Acidic protein msyB CSC00_0313 ENOG4105NAC (LipO)protein CSC00_0314 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) CSC00_0316 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) CSC00_0319 ENOG4108UQ5 membrane protein YcdZ CSC00_0320 ENOG4107XHZ cytoplasmic chaperone TorD family protein CSC00_0322 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase CSC00_0324 ENOG4105HEI LysR family (Transcriptional regulator CSC00_0325 ENOG4105EUB pirin domain protein CSC00_0326 ENOG4105CHJ isochorismatase hydrolase CSC00_0329 ENOG4105D5M phosphate starvation-inducible protein CSC00_0330 ENOG4105DBE peroxidase CSC00_0331 ENOG410650H (LipO)protein CSC00_0332 ENOG4105EKT )-iron permease CSC00_0333 ENOG4105D9N nucleoside CSC00_0335 ENOG4105CK7 Sodium proline symporter CSC00_0336 ENOG4105C26 Dehydrogenase CSC00_0338 ENOG4108R86 Transcriptional regulator CSC00_0339 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) CSC00_0340 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) CSC00_0341 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) CSC00_0342 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CSC00_0343 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) CSC00_0344 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) CSC00_0345 ENOG4105C2W permease CSC00_0349 ENOG4105XH3 CSC00_0350 ENOG4105D6F Phosphatase CSC00_0351 ENOG4107YPT transcriptional regulator CSC00_0352 ENOG4105CHR reductase CSC00_0355 ENOG4105CUB amino acid CSC00_0356 ENOG4105CFQ glutamine synthetase CSC00_0357 ENOG4108Z86 Glutamine amidotransferase CSC00_0358 ENOG4107VRI Transcriptional regulator CSC00_0359 ENOG4105C26 Dehydrogenase CSC00_0360 ENOG4105CJP fad dependent oxidoreductase CSC00_0361 ENOG4105EJC lysr family transcriptional regulator CSC00_0362 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CSC00_0363 ENOG4105C94 Transporter CSC00_0364 ENOG4105DVW rieske (2Fe-2S) CSC00_0365 ENOG4105C26 Dehydrogenase CSC00_0366 ENOG4105E3J oxidoreductase CSC00_0368 ENOG4105BZU Histidine kinase CSC00_0369 ENOG4105BZU Histidine kinase CSC00_0372 ENOG4107QSI ABC, transporter CSC00_0373 ENOG4108MN8 Membrane CSC00_0375 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 CSC00_0376 ENOG4108UQN AraC family transcriptional regulator CSC00_0377 ENOG4108V1U phospholipid-binding protein CSC00_0378 ENOG4105DR4 Methyltransferase CSC00_0380 ENOG4105K4P CoA-binding domain protein CSC00_0382 ENOG41088T4 Helicase IV CSC00_0383 ENOG410901E Membrane CSC00_0384 ENOG4105EM2 membrane CSC00_0385 ENOG4108RZ1 DNA transformation protein CSC00_0387 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) CSC00_0388 ENOG4105UYK outer membrane protein a CSC00_0389 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) CSC00_0390 ENOG4105DAN ATP-dependent protease CSC00_0391 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) CSC00_0393 ENOG4108Q2G (LipO)protein CSC00_0394 ENOG4105DY2 Paraquat-inducible protein b CSC00_0395 ENOG4105F1S paraquat-inducible protein a CSC00_0396 ENOG4105C5H ABC transporter CSC00_0397 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CSC00_0398 ENOG4105QVC MOSC domain-containing protein CSC00_0399 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) CSC00_0401 ENOG4108UZX fmn reductase CSC00_0402 ENOG4105GVF (ABC) transporter CSC00_0403 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CSC00_0404 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CSC00_0406 ENOG4105CD8 aminopeptidase N CSC00_0407 ENOG4107RH7 Nicotinate phosphoribosyltransferase CSC00_0408 ENOG4105CH2 amidohydrolase CSC00_0409 ENOG4105CE7 Amidase, hydantoinase carbamoylase family CSC00_0410 ENOG4105C44 Serine transporter CSC00_0411 ENOG4107RCH Diaminopropionate ammonia-lyase CSC00_0413 ENOG4105C5S asparaginyl-tRNA synthetase CSC00_0414 ENOG4105ZIT Porin Gram-negative type CSC00_0415 ENOG4105CGF Aromatic amino acid aminotransferase CSC00_0416 ENOG4105C5X domain protein CSC00_0417 ENOG4105EAQ (twin-arginine translocation) pathway signal CSC00_0418 ENOG4105DIT ErfK YbiS YcfS YnhG family protein CSC00_0420 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) CSC00_0421 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) CSC00_0422 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) CSC00_0423 ENOG4106371 Methyltransferase CSC00_0424 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups CSC00_0425 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) CSC00_0426 ENOG4105W49 UPF0434 protein CSC00_0427 ENOG4105T0Z Conserved Protein CSC00_0428 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) CSC00_0429 ENOG4105BZ1 (ABC) transporter CSC00_0430 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 CSC00_0431 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CSC00_0432 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CSC00_0433 ENOG4105CAT Cytidine monophosphate kinase CSC00_0434 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CSC00_0435 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CSC00_0436 ENOG4107VMU Membrane CSC00_0437 ENOG4105DDY UPF0142 protein ycaO CSC00_0438 ENOG4105TMB Formate nitrite transporter CSC00_0439 ENOG4105C6N Formate acetyltransferase CSC00_0440 ENOG4105F1A Pyruvate formate-lyase CSC00_0441 ENOG4108ISG Major Facilitator CSC00_0443 ENOG4107KGK dmso reductase anchor subunit CSC00_0444 ENOG4105QAX Iron-sulfur CSC00_0445 ENOG4107QY8 reductase CSC00_0446 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CSC00_0447 ENOG4105D1H recombination factor protein RarA CSC00_0448 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) CSC00_0449 ENOG4105CNU cell division protein FtsK CSC00_0450 ENOG4105EW9 transcriptional regulator AsnC family CSC00_0452 ENOG4105C3M thioredoxin reductase CSC00_0453 ENOG4108JJ9 ABC, transporter CSC00_0454 ENOG4108JJ8 (ABC) transporter CSC00_0455 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) CSC00_0456 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CSC00_0457 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CSC00_0459 ENOG4105VEQ Cold shock protein CSC00_0461 ENOG4105DJY efflux transporter, rnd family, mfp subunit CSC00_0462 ENOG4105CPB ATP-dependent endonuclease of the OLD family CSC00_0464 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CSC00_0466 ENOG4105DWU Membrane CSC00_0468 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CSC00_0470 ENOG4105C7K acetolactate synthase CSC00_0471 ENOG4105C5W Aldolase CSC00_0472 ENOG4105CGD Nad-dependent epimerase dehydratase CSC00_0473 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase CSC00_0474 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CSC00_0476 ENOG41064MM (LipO)protein CSC00_0477 ENOG4105E5Z arginine transporter ATP-binding subunit CSC00_0478 ENOG4106PMH Extracellular solute-binding protein family 3 CSC00_0479 ENOG4105GBT ABC transporter CSC00_0480 ENOG4105DMR ABC, transporter CSC00_0481 ENOG4106TNF Periplasmic binding protein CSC00_0482 ENOG4105BZU Histidine kinase CSC00_0483 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSC00_0484 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) CSC00_0485 ENOG4105RBQ inner membrane protein ybjO CSC00_0486 ENOG4105D38 putrescine abc transporter CSC00_0487 ENOG4105F38 ABC transporter, permease CSC00_0488 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CSC00_0489 ENOG4107RUE extracellular solute-binding protein family 1 CSC00_0490 ENOG4108RMJ sensory transduction regulator CSC00_0492 ENOG4108DBC nitroreductase CSC00_0493 ENOG4108DBC nitroreductase CSC00_0494 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress CSC00_0495 ENOG41090BQ Glutaredoxin CSC00_0496 ENOG4105GWF inner membrane protein YbjM CSC00_0497 ENOG4105D0C transport protein CSC00_0499 ENOG4108RFG Tetr family transcriptional regulator CSC00_0500 ENOG4106UW1 Major Facilitator superfamily CSC00_0501 ENOG4108HCJ Hydrolase CSC00_0502 ENOG4107QF7 multi-drug CSC00_0503 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CSC00_0504 ENOG4107FB0 transcriptional regulator DeoR family CSC00_0505 ENOG4105DZ1 carboxypeptidase CSC00_0507 ENOG4108TGY Glutathione S-transferase CSC00_0508 ENOG4105D8V Glucose sorbosone dehydrogenase CSC00_0509 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway CSC00_0511 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) CSC00_0512 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) CSC00_0513 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSC00_0514 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSC00_0515 ENOG4105DEF Extracellular solute-binding protein, family 5 CSC00_0516 ENOG4108JQ6 ABC transporter CSC00_0517 ENOG4105D44 asparaginase CSC00_0518 ENOG4105CVM Molybdenum cofactor synthesis domain protein CSC00_0519 ENOG4105D06 uba thif-type nad fad binding protein CSC00_0520 ENOG4105F1A Pyruvate formate-lyase CSC00_0521 ENOG4105C6N Formate acetyltransferase CSC00_0522 ENOG4108HCJ Hydrolase CSC00_0523 ENOG41072TH Protein of unknown function (DUF1479) CSC00_0524 ENOG4105ETE Transcriptional regulator (LacI family CSC00_0525 ENOG4105DPW Major facilitator superfamily MFS_1 CSC00_0527 ENOG4105C5H ABC transporter CSC00_0528 ENOG4105M2Z protein tyrosine serine phosphatase CSC00_0529 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CSC00_0530 ENOG4108TZY GntR Family Transcriptional Regulator CSC00_0531 ENOG4105CS2 ec 3.2.1.21 CSC00_0532 ENOG4105F4P )-transporter CSC00_0533 ENOG4105KST dependent repressor CSC00_0535 ENOG4108I6E Sulfatase CSC00_0536 ENOG4108T1M outer membrane protein x CSC00_0540 ENOG4107R0W ABC transporter CSC00_0541 ENOG4105E5Q amino acid AbC transporter CSC00_0542 ENOG4105CDA abc transporter atp-binding protein CSC00_0543 ENOG4105D8X mechanosensitive ion channel CSC00_0544 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) CSC00_0545 ENOG4105EW6 flavin reductase domain protein, FMN-binding CSC00_0547 ENOG4105KSC Transcriptional regulator, TraR DksA family CSC00_0548 ENOG4105VR4 UPF0379 protein ybiJ CSC00_0549 ENOG4108MTB glycosyl transferase family CSC00_0550 ENOG4105DVT helicase CSC00_0551 ENOG4105C1J atp-dependent rna helicase CSC00_0555 ENOG4105DJB Major Facilitator Superfamily CSC00_0557 ENOG4108PZW LysR family Transcriptional regulator CSC00_0558 ENOG4107MVR Transcriptional regulator CSC00_0559 ENOG4105D0S secretion protein (HlyD CSC00_0560 ENOG4105CJ1 ABC, transporter CSC00_0561 ENOG4107QWP ABC-2 type transporter CSC00_0562 ENOG4107QWP ABC-2 type transporter CSC00_0563 ENOG4105I9U inner membrane protein ybhQ CSC00_0564 ENOG4105X23 Endonuclease Exonuclease phosphatase CSC00_0565 ENOG4105DZQ phospholipase D Transphosphatidylase CSC00_0566 ENOG4107UXM Membrane CSC00_0567 ENOG4105HFZ Membrane CSC00_0568 ENOG4108ZAF Molybdopterin CSC00_0569 ENOG4105M00 molybdopterin converting factor, subunit 1 CSC00_0570 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CSC00_0571 ENOG4108RIR Molybdenum cofactor biosynthesis protein CSC00_0572 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CSC00_0573 ENOG4105CHW UPF0052 protein CSC00_0574 ENOG4105DIJ Phosphoethanolamine transferase CSC00_0575 ENOG4105XJC Two component transcriptional regulator (Winged helix family CSC00_0576 ENOG4105ECM Sensor protein basS pmrB CSC00_0577 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CSC00_0580 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CSC00_0581 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CSC00_0582 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CSC00_0583 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CSC00_0584 ENOG4108V1U phospholipid-binding protein CSC00_0586 ENOG4105C85 amino acid CSC00_0587 ENOG4105C84 Histidine ammonia-lyase CSC00_0588 ENOG4105CGP Urocanate hydratase CSC00_0590 ENOG41088SP formiminoglutamate hydrolase CSC00_0591 ENOG4105CI2 imidazolone-5-propionate hydrolase CSC00_0592 ENOG4105NBR Pectinesterase CSC00_0598 ENOG4108XDN Transcriptional regulator CSC00_0599 ENOG4105BZU Histidine kinase CSC00_0600 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component CSC00_0603 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CSC00_0604 ENOG4108K4B hydrolase CSC00_0605 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) CSC00_0606 ENOG4105E0C molybdate abc transporter CSC00_0607 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CSC00_0608 ENOG410680R Protein of unknown function (DUF2592) CSC00_0609 ENOG4105F4R Transcriptional regulator mode CSC00_0610 ENOG4105DKW ABC transporter CSC00_0612 ENOG4105CMR udp-glucose 4-epimerase CSC00_0613 ENOG4105F0Z galactose-1-phosphate uridylyltransferase CSC00_0614 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CSC00_0615 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CSC00_0617 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CSC00_0618 ENOG4105JND homeobox protein CSC00_0619 ENOG4105PGM cation diffusion facilitator family transporter CSC00_0620 ENOG4106Z1T Nicotinamide Mononucleotide Transporter CSC00_0621 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CSC00_0630 ENOG4105UFD tol-pal system protein YbgF CSC00_0631 ENOG4105KCK Peptidoglycan-associated lipoprotein CSC00_0633 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA CSC00_0634 ENOG4105M8F Biopolymer transport protein exbD tolR CSC00_0635 ENOG4105E02 MotA TolQ exbB proton channel CSC00_0636 ENOG4107YD3 Thioesterase CSC00_0637 ENOG4105KJB cyd operon protein YbgE CSC00_0639 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CSC00_0640 ENOG4105C4M (Ubiquinol oxidase) subunit I CSC00_0643 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CSC00_0645 ENOG4105C7S Dehydrogenase CSC00_0646 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CSC00_0647 ENOG4105E33 succinate dehydrogenase CSC00_0648 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) CSC00_0650 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein CSC00_0651 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit CSC00_0652 ENOG4105BZN citrate synthase CSC00_0654 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) CSC00_0658 ENOG4105E7W lamb ycsf family protein CSC00_0659 ENOG4107R7A Allophanate hydrolase subunit 2 CSC00_0660 ENOG4105P4J Allophanate hydrolase, subunit 1 CSC00_0661 ENOG4107QNR UPF0135 protein CSC00_0662 ENOG4105DUX Transporter CSC00_0663 ENOG4105CVP deoxyribo-dipyrimidine photolyase CSC00_0664 ENOG4105XIQ Protein of unknown function (DUF2517) CSC00_0665 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CSC00_0666 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CSC00_0667 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CSC00_0668 ENOG4105C08 Histidine kinase CSC00_0669 ENOG4105EEX Two component transcriptional regulator (Winged helix family CSC00_0671 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 CSC00_0672 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) CSC00_0673 ENOG4105EV9 Alpha Beta Hydrolase CSC00_0674 ENOG4105NNH LexA regulated protein CSC00_0675 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) CSC00_0676 ENOG41090R7 Ferric uptake CSC00_0677 ENOG4105GX6 (LipO)protein CSC00_0678 ENOG4105J5J Outer membrane porin CSC00_0680 ENOG4105CX6 glutaminyL-tRNA synthetase CSC00_0681 ENOG4105CI1 PTS System CSC00_0682 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CSC00_0683 ENOG4105CE4 GlcNAc 6-P deacetylase CSC00_0684 ENOG4105E2R ROK family CSC00_0685 ENOG4105D4U had-superfamily hydrolase, subfamily iia CSC00_0686 ENOG4105CAQ asparagine synthetase CSC00_0694 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CSC00_0695 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CSC00_0696 ENOG4105C9A Phoh family CSC00_0698 ENOG4108JU5 Magnesium and cobalt efflux protein CSC00_0699 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) CSC00_0700 ENOG4107RP9 extracellular solute-binding protein, family 3 CSC00_0701 ENOG4105EAD ABC transporter CSC00_0702 ENOG4105DRP amino acid AbC transporter CSC00_0703 ENOG4105CDA abc transporter atp-binding protein CSC00_0707 ENOG4107PAI alpha helical protein CSC00_0708 ENOG4105C8T Leucyl-tRNA synthetase CSC00_0710 ENOG4105DJF DNA polymerase III, delta' subunit CSC00_0711 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CSC00_0712 ENOG4108TGR phosphatase CSC00_0713 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) CSC00_0715 ENOG4105CJN penicillin-binding protein CSC00_0716 ENOG4105CNI cell division protein FtsW CSC00_0717 ENOG4105K6T rare lipoprotein A CSC00_0718 ENOG4105DZ1 carboxypeptidase CSC00_0720 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CSC00_0721 ENOG41064T2 transcriptional regulator, lysR family CSC00_0723 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) CSC00_0724 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CSC00_0726 ENOG4105VEQ Cold shock protein CSC00_0727 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) CSC00_0729 ENOG4105CEE C4-dicarboxylate transporter CSC00_0730 ENOG4105KTS ribonuclease CSC00_0731 ENOG4105NXH GreA GreB family elongation factor CSC00_0732 ENOG4108U51 Universal stress protein CSC00_0733 ENOG4108JU3 Alkyl hydroperoxide reductase CSC00_0734 ENOG4105D3R alkyl hydroperoxide reductase CSC00_0735 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase CSC00_0736 ENOG4105DQS Transcriptional regulator CSC00_0737 ENOG4105BZV Phosphoadenosine phosphosulfate reductase CSC00_0738 ENOG4105GTN ParB Domain Protein Nuclease CSC00_0739 ENOG4105CHM Aminotransferase CSC00_0740 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) CSC00_0741 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CSC00_0744 ENOG4105C2J ABC transporter CSC00_0746 ENOG4105CNN ABC, transporter CSC00_0748 ENOG4108M3J Dehydrogenase CSC00_0750 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CSC00_0751 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin CSC00_0753 ENOG4105DZC cytosine deaminase CSC00_0754 ENOG4105ETE Transcriptional regulator (LacI family CSC00_0755 ENOG4105ECY inositol monophosphatase CSC00_0756 ENOG4105CXY transporter CSC00_0757 ENOG4105D6F Phosphatase CSC00_0758 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CSC00_0759 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CSC00_0762 ENOG4105CNN ABC, transporter CSC00_0763 ENOG4105C2J ABC transporter CSC00_0765 ENOG4107SCQ Iron-containing alcohol dehydrogenase CSC00_0766 ENOG4105F6U Short-chain dehydrogenase reductase Sdr CSC00_0769 ENOG4105VCD cytoplasmic protein CSC00_0770 ENOG4105D22 carbon starvation protein CSC00_0771 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) CSC00_0772 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CSC00_0773 ENOG4105WQI isochorismatase CSC00_0774 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CSC00_0775 ENOG4105E4F Isochorismate synthase CSC00_0776 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein CSC00_0777 ENOG4105E8G Major facilitator Superfamily CSC00_0778 ENOG4105DQ5 transport system permease protein CSC00_0779 ENOG4105TVJ transport system, permease CSC00_0780 ENOG4105E0A ABC, transporter CSC00_0781 ENOG4105C0W non-ribosomal peptide synthetase CSC00_0782 ENOG41085A6 mbth domain-containing protein CSC00_0783 ENOG4105E93 esterase CSC00_0784 ENOG4107RNH Outer membrane receptor FepA CSC00_0785 ENOG4108TSE Transferase CSC00_0786 ENOG4108IUS Transketolase CSC00_0787 ENOG4108HHA Transketolase CSC00_0788 ENOG4105DKT Transcriptional regulator CSC00_0789 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CSC00_0790 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CSC00_0792 ENOG4105C2J ABC transporter CSC00_0793 ENOG4105CNN ABC, transporter CSC00_0795 ENOG4108R85 Short chain dehydrogenase CSC00_0798 ENOG410810E transcriptional regulator, lysR family CSC00_0799 ENOG4105CUY Mechanosensitive ion channel CSC00_0800 ENOG4108WN0 inhibitor of vertebrate lysozyme CSC00_0801 ENOG4105C94 Transporter CSC00_0804 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) CSC00_0806 ENOG4105DEF Extracellular solute-binding protein, family 5 CSC00_0807 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSC00_0808 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSC00_0809 ENOG4105C3U ABC transporter CSC00_0810 ENOG4108JQ7 (ABC) transporter CSC00_0812 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CSC00_0813 ENOG4105EMU Dehydrogenase CSC00_0815 ENOG4105GBT ABC transporter CSC00_0816 ENOG4105DRP amino acid AbC transporter CSC00_0817 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) CSC00_0819 ENOG4105CHM Aminotransferase CSC00_0820 ENOG4105T38 integral membrane protein CSC00_0821 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) CSC00_0822 ENOG4108T58 Mg2 transport protein CorA CSC00_0823 ENOG4105DQ6 Transposase CSC00_0829 ENOG4105WQ6 Membrane CSC00_0830 ENOG4105HFT AraC family transcriptional regulator CSC00_0832 ENOG410630P Transcriptional regulator CSC00_0833 ENOG4105MSB protein, conserved in bacteria CSC00_0834 ENOG4108RCM Nitroreductase CSC00_0836 ENOG4108IQ3 PTS system CSC00_0838 ENOG4105F3R pts system mannose fructose sorbose family iid CSC00_0839 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CSC00_0840 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine CSC00_0841 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CSC00_0845 ENOG4105CUY Mechanosensitive ion channel CSC00_0850 ENOG4108GWT fimbrillin MatB CSC00_0852 ENOG4108N3D putative enzyme CSC00_0853 ENOG4106PYX Receptor CSC00_0855 ENOG4105ISV protein with bipartite regulator domain CSC00_0858 ENOG4105CK5 oxidoreductase CSC00_0860 ENOG4105EAA nucleoside CSC00_0861 ENOG4105C85 amino acid CSC00_0863 ENOG4108NS2 receptor CSC00_0864 ENOG4105C26 Dehydrogenase CSC00_0865 ENOG4105CJP fad dependent oxidoreductase CSC00_0867 ENOG4105CUB amino acid CSC00_0869 ENOG4105DGU Histone deacetylase CSC00_0871 ENOG4108UAJ Transcriptional regulator CSC00_0873 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) CSC00_0876 ENOG4105CPC Aldo Keto reductase CSC00_0877 ENOG4105E89 ABC transporter CSC00_0878 ENOG4105CH2 amidohydrolase CSC00_0885 ENOG4105EHG Permease protein CSC00_0886 ENOG4105E0A ABC, transporter CSC00_0887 ENOG4105EFX secretion protein, HlyD family CSC00_0888 ENOG4105KK7 inner membrane protein YiaW CSC00_0891 ENOG4105D7K pfkb domain protein CSC00_0892 ENOG4108M0B Sucrose porin CSC00_0893 ENOG4105C5Y PTS System CSC00_0894 ENOG4108HKT sucrose-6-phosphate hydrolase CSC00_0895 ENOG4105WBN Transcriptional regulator (LacI family CSC00_0898 ENOG4108HWV )-transporter CSC00_0899 ENOG4105C2J ABC transporter CSC00_0907 ENOG4105CRK lysyL-tRNA synthetase CSC00_0908 ENOG4105DUX Transporter CSC00_0909 ENOG4105CXN decarboxylase CSC00_0910 ENOG4105D5Q Arginine ornithine antiporter CSC00_0911 ENOG4108M3R transcriptional activator CadC CSC00_0913 ENOG4105D1S lipid A biosynthesis CSC00_0916 ENOG4105CW0 outer membrane usher protein CSC00_0917 ENOG4105GQR Chaperone CSC00_0918 ENOG4105X0I Fimbrial CSC00_0921 ENOG4105BZN citrate synthase CSC00_0927 ENOG4105WQ3 Rna-binding protein CSC00_0929 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CSC00_0930 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) CSC00_0932 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CSC00_0933 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CSC00_0937 ENOG4105CV6 ABC transporter, permease CSC00_0938 ENOG4108I0Y (ABC) transporter CSC00_0939 ENOG4108UJV acyl-CoA thioesterase i CSC00_0940 ENOG4105E1F short-chain dehydrogenase reductase CSC00_0941 ENOG4107QR8 Thioredoxin CSC00_0942 ENOG4105C4B ABC transporter, permease CSC00_0943 ENOG41083J0 (ABC) transporter CSC00_0944 ENOG4107QX8 SPFH domain, Band 7 family protein CSC00_0945 ENOG4105G5H Membrane CSC00_0946 ENOG4108Z6Z Transcriptional regulator CSC00_0947 ENOG4105C59 p-type ATPase CSC00_0948 ENOG4105MBR gumn family CSC00_0949 ENOG4108Z66 YbaK ebsC protein CSC00_0950 ENOG4105CGH 5'-nucleotidase CSC00_0951 ENOG4105EU0 Major facilitator Superfamily CSC00_0953 ENOG4105CKD glutathione-regulated potassium-efflux system protein CSC00_0954 ENOG4107RE1 Inosine-guanosine kinase CSC00_0957 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CSC00_0958 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CSC00_0960 ENOG4107QMP dna polymerase iii subunits gamma and tau CSC00_0961 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CSC00_0962 ENOG4105WD1 Membrane CSC00_0963 ENOG4108URS primosomal replication protein n'' CSC00_0964 ENOG4106428 Protein of unknown function (DUF2496) CSC00_0965 ENOG4105DNE Transposase CSC00_0966 ENOG4105EGS Mechanosensitive ion channel CSC00_0967 ENOG4108IG5 Transcriptional regulator CSC00_0968 ENOG4105C1P efflux transporter, rnd family, mfp subunit CSC00_0969 ENOG4105BZS acriflavin resistance protein CSC00_0970 ENOG4108UKR Biofilm formation regulator YbaJ CSC00_0972 ENOG4108UW5 maltose o-acetyltransferase CSC00_0974 ENOG4105GSJ Inner membrane protein ylaC CSC00_0979 ENOG4105ETE Transcriptional regulator (LacI family CSC00_0980 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) CSC00_0981 ENOG4105CI1 PTS System CSC00_0982 ENOG4105C4C beta-galactosidase CSC00_0984 ENOG4105EG2 ABC transporter, permease CSC00_0986 ENOG4107FKK extracellular solute-binding protein family 1 CSC00_0989 ENOG41066DG (EAL) domain protein CSC00_0990 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter CSC00_0991 ENOG41061MD high-affinity nickel-transporter CSC00_0992 ENOG4108VW9 Membrane CSC00_0997 ENOG41080UX Methyltransferase CSC00_0998 ENOG4108MNP Glycoprotein polysaccharide metabolism CSC00_0999 ENOG4105C29 acyl-CoA thioesterase CSC00_1000 ENOG4105BZU Histidine kinase CSC00_1001 ENOG4108YZA Nitrogen regulatory protein pii CSC00_1002 ENOG4105BZ1 (ABC) transporter CSC00_1003 ENOG4105BZ1 (ABC) transporter CSC00_1004 ENOG4108XM1 transcriptional regulator AsnC family CSC00_1006 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) CSC00_1007 ENOG4108NFA extracellular solute-binding protein CSC00_1008 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CSC00_1009 ENOG4108TGP Thioesterase superfamily protein CSC00_1010 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein CSC00_1011 ENOG4105EIN peptidylprolyl cis-trans isomerase CSC00_1017 ENOG4105K70 DNA-binding protein CSC00_1018 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CSC00_1019 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CSC00_1021 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CSC00_1023 ENOG4105M85 Bola protein CSC00_1024 ENOG4105IEY (LipO)protein CSC00_1025 ENOG4105EYM Major Facilitator superfamily CSC00_1026 ENOG4105E2S oxidase) subunit II CSC00_1027 ENOG4105BZ9 Cytochrome C oxidase, subunit I CSC00_1028 ENOG4105CCU oxidase (Subunit III) CSC00_1029 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) CSC00_1030 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CSC00_1032 ENOG4107HP6 Transcriptional regulator CSC00_1033 ENOG4105E2X shikimate dehydrogenase CSC00_1034 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein CSC00_1036 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein CSC00_1038 ENOG4105D2S major facilitator superfamily CSC00_1039 ENOG4105CIB oxidoreductase Domain protein CSC00_1040 ENOG4107RDB Major Facilitator CSC00_1042 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CSC00_1043 ENOG4107S0N DJ-1 family CSC00_1045 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) CSC00_1047 ENOG4105CTB Polyprenyl synthetase CSC00_1048 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CSC00_1049 ENOG4105CPC Aldo Keto reductase CSC00_1050 ENOG4108ZAI phosphatidylglycerophosphatase a CSC00_1051 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CSC00_1052 ENOG4107YIM Involved in the transcription termination process (By similarity) CSC00_1053 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CSC00_1054 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CSC00_1056 ENOG4108KIC (LipO)protein CSC00_1058 ENOG4105DRB nucleoside-specific channel-forming protein CSC00_1061 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CSC00_1062 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CSC00_1063 ENOG4105VIE preprotein translocase, subunit YajC CSC00_1067 ENOG4108ZYK Acyl carrier protein phosphodiesterase CSC00_1068 ENOG4105D3R alkyl hydroperoxide reductase CSC00_1070 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia CSC00_1073 ENOG4108MGF sugar kinase CSC00_1075 ENOG4105CI2 imidazolone-5-propionate hydrolase CSC00_1077 ENOG4105CHJ isochorismatase hydrolase CSC00_1079 ENOG4105EQ1 Transcriptional regulator CSC00_1080 ENOG4107R28 alpha amylase, catalytic region CSC00_1081 ENOG4105C85 amino acid CSC00_1082 ENOG4105CWM branched-chain amino acid transport system II carrier protein CSC00_1083 ENOG4105BZU Histidine kinase CSC00_1084 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSC00_1085 ENOG4107RH8 nuclease SbcCD subunit D CSC00_1086 ENOG4105EYH Exonuclease CSC00_1087 ENOG4105DKQ ROK family CSC00_1090 ENOG4105HBA AroM protein CSC00_1091 ENOG4105SS3 CSC00_1092 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CSC00_1093 ENOG4105G4C Periplasmic ligand-binding sensor protein CSC00_1094 ENOG4108UPT UPF0178 protein CSC00_1095 ENOG4105II7 pyrroline-5-carboxylate reductase CSC00_1096 ENOG4105VIF phosphate starvation-inducible protein CSC00_1097 ENOG4105G6Z alkaline phosphatase CSC00_1101 ENOG4105CPF Cell wall formation (By similarity) CSC00_1102 ENOG4105UNH Membrane CSC00_1103 ENOG4105FR5 inner membrane protein YaiY CSC00_1104 ENOG4107QS8 (LipO)protein CSC00_1105 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 CSC00_1106 ENOG4108RWI nicotinamidase CSC00_1107 ENOG4107R6D beta-lactam binding protein AmpH CSC00_1108 ENOG4105D52 delta-aminolevulinic acid dehydratase CSC00_1110 ENOG4105E2B Taurine dioxygenase CSC00_1111 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CSC00_1112 ENOG4108ETV ABC transporter CSC00_1113 ENOG4106FTQ Taurine ABC transporter, periplasmic CSC00_1114 ENOG4107QK5 Homocysteine s-methyltransferase CSC00_1115 ENOG4108IQI permease CSC00_1117 ENOG4105C85 amino acid CSC00_1118 ENOG4105CPD ethanolamine ammonia-lyase CSC00_1119 ENOG4107FQ9 ethanolamine ammonia-lyase CSC00_1122 ENOG4105C32 Amino acid ABC transporter (Permease) CSC00_1123 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CSC00_1124 ENOG4105C0Z ABC transporter CSC00_1125 ENOG4108IV0 ABC, transporter CSC00_1127 ENOG4105CT1 (ABC) transporter CSC00_1128 ENOG4105CDA abc transporter atp-binding protein CSC00_1129 ENOG4105E5Q amino acid AbC transporter CSC00_1130 ENOG4105DRP amino acid AbC transporter CSC00_1131 ENOG4108UD7 cell wall organization CSC00_1132 ENOG4106PYX Receptor CSC00_1133 ENOG4108N3D putative enzyme CSC00_1134 ENOG4108NN8 Fimbrial protein CSC00_1135 ENOG4108GWT fimbrillin MatB CSC00_1136 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon CSC00_1139 ENOG4105EHI Phosphonate ABC transporter, periplasmic CSC00_1141 ENOG4105S7S phosphonate abc transporter CSC00_1145 ENOG4108QBX (LipO)protein CSC00_1146 ENOG4105FCK Membrane CSC00_1148 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CSC00_1149 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CSC00_1151 ENOG4105DFP Integrase CSC00_1152 ENOG4107QJE Chromosome Partitioning Protein CSC00_1155 ENOG4105ZTC transcriptional activator, Ogr delta CSC00_1167 ENOG4107R0V Pyruvate dehydrogenase CSC00_1168 ENOG4105CPP Dehydrogenase, E1 component CSC00_1172 ENOG41061GT Aldolase CSC00_1174 ENOG4105CMG Carbohydrate kinase CSC00_1175 ENOG4105CHR reductase CSC00_1176 ENOG4108JQ1 Dehydrogenase CSC00_1177 ENOG4105DT3 PTS system, galactitol-specific IIc component CSC00_1178 ENOG4108TGY Glutathione S-transferase CSC00_1179 ENOG4105DTA methyltransferase CSC00_1180 ENOG4105YCT UPF0386 protein CSC00_1182 ENOG4105D5U fad dependent oxidoreductase CSC00_1183 ENOG4105C26 Dehydrogenase CSC00_1184 ENOG4108JPW Aminotransferase CSC00_1185 ENOG4105C85 amino acid CSC00_1186 ENOG4108PVQ transcriptional regulator CSC00_1187 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) CSC00_1188 ENOG4105V1F Fermentation respiration switch protein CSC00_1190 ENOG4105CIN aminoacyl-histidine dipeptidase CSC00_1191 ENOG4108HYG acetyltransferase CSC00_1192 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CSC00_1195 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) CSC00_1196 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CSC00_1197 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CSC00_1198 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CSC00_1199 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CSC00_1200 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CSC00_1202 ENOG4105F7V ErfK ybiS ycfS ynhG family protein CSC00_1203 ENOG4105E7A Glutamine amidotransferase CSC00_1204 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CSC00_1205 ENOG4107QPN acyl-Coa dehydrogenase CSC00_1206 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CSC00_1207 ENOG4108VP3 Lysine exporter protein (LysE YggA) CSC00_1208 ENOG41090KR LysR family transcriptional Regulator CSC00_1210 ENOG4107RZZ dna polymerase iii epsilon subunit CSC00_1211 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CSC00_1212 ENOG4105D1A Methyltransferase CSC00_1213 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CSC00_1214 ENOG4105E9H Lytic Murein transglycosylase CSC00_1215 ENOG4105F2W methyltransferase CSC00_1217 ENOG4105F27 Major Facilitator CSC00_1218 ENOG4105HEI LysR family (Transcriptional regulator CSC00_1219 ENOG4105CV8 reductase CSC00_1226 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CSC00_1227 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CSC00_1228 ENOG4108UMI ABC transporter, permease CSC00_1229 ENOG4105D01 (LipO)protein CSC00_1230 ENOG4108R8X outer membrane lipoprotein CSC00_1231 ENOG4108R96 Methyltransferase, YaeB family CSC00_1232 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CSC00_1233 ENOG4108UY0 (LipO)protein CSC00_1234 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion CSC00_1235 ENOG4108YZN class I peptide chain release factor CSC00_1236 ENOG4108VWS Yaeq family CSC00_1237 ENOG4105M1T rho-binding antiterminator CSC00_1238 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CSC00_1239 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CSC00_1240 ENOG4105CXN decarboxylase CSC00_1241 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CSC00_1242 ENOG4105C0B DNA polymerase III (alpha subunit) CSC00_1243 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CSC00_1244 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CSC00_1245 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CSC00_1248 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) CSC00_1250 ENOG4105DZP Membrane-associated zinc metalloprotease CSC00_1251 ENOG4105KNE Phosphatidate cytidylyltransferase CSC00_1253 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CSC00_1255 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CSC00_1257 ENOG4105CE9 30S ribosomal protein S2 CSC00_1258 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CSC00_1259 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) CSC00_1261 ENOG4108T8E UPF0325 protein CSC00_1262 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR CSC00_1263 ENOG4105C0H protease CSC00_1264 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein CSC00_1265 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CSC00_1266 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CSC00_1267 ENOG4105EN6 Membrane CSC00_1268 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CSC00_1269 ENOG4105CMQ Chloride channel CSC00_1270 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CSC00_1271 ENOG4105S6R Iron-hydroxamate transporter permease subunit CSC00_1272 ENOG4105J76 Periplasmic binding protein CSC00_1273 ENOG4105E0A ABC, transporter CSC00_1274 ENOG4105E0K tonB-dependent siderophore receptor CSC00_1276 ENOG4105BZ4 penicillin-binding protein CSC00_1296 ENOG4105CQ7 ATP-dependent helicase CSC00_1297 ENOG4107XID 2'-5' rna ligase CSC00_1298 ENOG4105PW4 Sugar fermentation stimulation protein homolog CSC00_1299 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters CSC00_1300 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) CSC00_1301 ENOG4105DJ0 Poly(A) Polymerase CSC00_1302 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CSC00_1303 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CSC00_1304 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CSC00_1305 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CSC00_1306 ENOG4107BJW polysaccharide deacetylase CSC00_1307 ENOG4108YTN IIa component CSC00_1308 ENOG4105E3A (ABC) transporter CSC00_1309 ENOG4105DA5 (ABC) transporter CSC00_1310 ENOG41077A9 carbonic anhydrase CSC00_1311 ENOG4108UGV hypoxanthine phosphoribosyltransferase CSC00_1313 ENOG4105DZG Dehydrogenase CSC00_1314 ENOG4105E3B Multicopper oxidase CSC00_1315 ENOG4108ZRK uncharacterized protein yacC CSC00_1318 ENOG4105MP0 transposase CSC00_1321 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CSC00_1322 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CSC00_1323 ENOG4108ZIG UPF0231 protein CSC00_1324 ENOG4107QIJ Aconitate hydratase 2 CSC00_1327 ENOG4108NST exported protein CSC00_1330 ENOG4107QN2 dihydrolipoyl dehydrogenase CSC00_1331 ENOG4107QSN dihydrolipoamide acetyltransferase CSC00_1332 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CSC00_1333 ENOG41073TP transcriptional regulator CSC00_1335 ENOG4105C85 amino acid CSC00_1336 ENOG4105CT4 transporter CSC00_1337 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) CSC00_1338 ENOG4106A72 regulatory protein AmpE CSC00_1340 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CSC00_1341 ENOG4108ZUW Major pilin subunit CSC00_1342 ENOG4107QHF type ii secretion system protein e CSC00_1343 ENOG4105D7Q type ii secretion system CSC00_1344 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CSC00_1346 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CSC00_1347 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) CSC00_1348 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) CSC00_1349 ENOG4105M6F mutator MutT protein CSC00_1350 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CSC00_1351 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) CSC00_1352 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CSC00_1353 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CSC00_1354 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CSC00_1355 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) CSC00_1356 ENOG4105CPF Cell wall formation (By similarity) CSC00_1357 ENOG4105DFU Cell wall formation (By similarity) CSC00_1358 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CSC00_1359 ENOG4105CNI cell division protein FtsW CSC00_1361 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CSC00_1362 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) CSC00_1363 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CSC00_1364 ENOG4105CJN penicillin-binding protein CSC00_1365 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) CSC00_1366 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CSC00_1368 ENOG4107B7Y DNA-binding transcriptional regulator FruR CSC00_1369 ENOG4108ZP8 Acetolactate synthase small subunit CSC00_1370 ENOG4105C7K acetolactate synthase CSC00_1371 ENOG41064T2 transcriptional regulator, lysR family CSC00_1373 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CSC00_1375 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CSC00_1376 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CSC00_1380 ENOG4105EMV Major Facilitator CSC00_1381 ENOG4105FF2 Type I DHQase CSC00_1382 ENOG4105C5Q Transcriptional regulator CSC00_1383 ENOG4105DJB Major Facilitator Superfamily CSC00_1384 ENOG4105S8Q sugar efflux transporter CSC00_1387 ENOG4105DP9 ABC transporter CSC00_1388 ENOG4106SMU thiamine transporter membrane protein CSC00_1390 ENOG4108KF1 Membrane CSC00_1393 ENOG4105EF1 ribulokinase CSC00_1394 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) CSC00_1395 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase CSC00_1396 ENOG4105CQ2 DNA polymerase CSC00_1397 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) CSC00_1398 ENOG4105D3G Pseudouridine synthase CSC00_1400 ENOG4105D2K citrate carrier protein CSC00_1401 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CSC00_1402 ENOG4106YYS transcriptional regulatory protein CSC00_1403 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) CSC00_1404 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) CSC00_1406 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) CSC00_1407 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CSC00_1409 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CSC00_1410 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CSC00_1411 ENOG4105CKD glutathione-regulated potassium-efflux system protein CSC00_1413 ENOG4105M5B (LipO)protein CSC00_1414 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CSC00_1415 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CSC00_1418 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CSC00_1419 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase CSC00_1420 ENOG4105CHY citrate lyase, alpha CSC00_1421 ENOG4105CI0 Citrate lyase CSC00_1422 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) CSC00_1423 ENOG4105DUA (citrate (pro-3S)-lyase ligase CSC00_1424 ENOG4105D2K citrate carrier protein CSC00_1426 ENOG4107QSA Oxaloacetate decarboxylase CSC00_1427 ENOG4105D9Q decarboxylase (Beta subunit) CSC00_1428 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CSC00_1429 ENOG4106YYS transcriptional regulatory protein CSC00_1430 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CSC00_1431 ENOG4105EXG Transcriptional regulator CSC00_1432 ENOG4105DU0 nucleoside hydrolase CSC00_1434 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase CSC00_1435 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CSC00_1437 ENOG4105DTN riboflavin biosynthesis protein ribF CSC00_1440 ENOG41063Z6 transcriptional regulator, lysR family CSC00_1441 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CSC00_1442 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CSC00_1443 ENOG4105CFG Acts as a chaperone (By similarity) CSC00_1444 ENOG4108WTA UPF0412 protein YaaI CSC00_1445 ENOG4108QUJ UPF0174 protein YaaW CSC00_1446 ENOG4106HK8 GPR1 FUN34 yaaH family protein CSC00_1447 ENOG4105CSH Transporter CSC00_1448 ENOG4108RIR Molybdenum cofactor biosynthesis protein CSC00_1450 ENOG4105BZG amino acid carrier protein CSC00_1451 ENOG4105D1Q UPF0246 protein CSC00_1453 ENOG4105D98 threonine synthase CSC00_1454 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CSC00_1455 ENOG4105CFH Aspartokinase CSC00_1457 ENOG4106FVC RNA methyltransferase CSC00_1458 ENOG41065U4 response regulator CSC00_1459 ENOG4105CT7 inner membrane cred family protein CSC00_1460 ENOG4105EB3 Histidine kinase CSC00_1461 ENOG4105E3W Two component transcriptional regulator (Winged helix family CSC00_1462 ENOG4108RH0 Crea protein CSC00_1463 ENOG4105UEI Transcriptional Regulator AraC Family CSC00_1464 ENOG4105CVJ phosphoglycerate mutase CSC00_1465 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CSC00_1466 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) CSC00_1467 ENOG4107SC1 transglycosylase CSC00_1469 ENOG4105C5H ABC transporter CSC00_1470 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase CSC00_1471 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CSC00_1472 ENOG4105EAC phosphoserine phosphatase CSC00_1473 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) CSC00_1474 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) CSC00_1477 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CSC00_1479 ENOG4105D9N nucleoside CSC00_1480 ENOG4105EYA deoxyribonuclease CSC00_1481 ENOG4108NRW Phospholipase, patatin family CSC00_1483 ENOG4105K3G Periplasmic Protein CSC00_1484 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CSC00_1485 ENOG4105PAD Hydrolase CSC00_1486 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CSC00_1487 ENOG4108WPU DNA polymerase III subunit psi CSC00_1488 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) CSC00_1492 ENOG4105YBH Protein of unknown function (DUF1435) CSC00_1494 ENOG4106TD9 Diguanylate cyclase CSC00_1495 ENOG4108819 ferric iron reductase CSC00_1496 ENOG4105CK1 PTS System CSC00_1497 ENOG4108UIN ybak prolyl-trna synthetase associated region CSC00_1498 ENOG4108T94 DNA-binding transcriptional activator BglJ CSC00_1499 ENOG4108N8T regulatoR CSC00_1501 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase CSC00_1503 ENOG4105DWK Membrane CSC00_1504 ENOG4107XM3 UPF0442 protein CSC00_1505 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) CSC00_1506 ENOG4106CVF DNA replication protein CSC00_1507 ENOG4105RI1 glycoprotein receptor CSC00_1509 ENOG4105DNE Transposase CSC00_1512 ENOG4105F3R pts system mannose fructose sorbose family iid CSC00_1513 ENOG4105ETZ PTS System CSC00_1514 ENOG4105KPI PTS system sorbose subfamily IIB component CSC00_1516 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CSC00_1517 ENOG4107QZW Altronate oxidoreductase CSC00_1518 ENOG4105CPQ Dehydrogenase CSC00_1519 ENOG410617M Transcriptional regulator CSC00_1520 ENOG4108I5G Major Facilitator superfamily CSC00_1522 ENOG4105XYF acetyltransferase CSC00_1523 ENOG4106KNT transcriptional regulator CSC00_1524 ENOG4108RTU Aldolase CSC00_1525 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 CSC00_1531 ENOG4105DG4 malate L-lactate dehydrogenase CSC00_1534 ENOG4108V8F Transcriptional regulator, MarR family CSC00_1536 ENOG4105ERH Fumarylacetoacetate hydrolase CSC00_1538 ENOG4105C26 Dehydrogenase CSC00_1539 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase CSC00_1542 ENOG4105CNV Aldolase CSC00_1545 ENOG4105EFA 4-hydroxyphenylacetate CSC00_1546 ENOG4107UWN reductase CSC00_1549 ENOG4105D22 carbon starvation protein CSC00_1550 ENOG4105VCD cytoplasmic protein CSC00_1551 ENOG4105CKI cobalamin synthesis protein CSC00_1553 ENOG4105C26 Dehydrogenase CSC00_1554 ENOG4105DNE Transposase CSC00_1555 ENOG4106AXJ AraC family transcriptional regulator CSC00_1557 ENOG4106BRA Membrane CSC00_1558 ENOG41083G8 Multidrug resistance protein MdtM CSC00_1560 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase CSC00_1561 ENOG4105CIZ coA-substrate-specific enzyme activase CSC00_1564 ENOG4105EFX secretion protein, HlyD family CSC00_1566 ENOG4106DIZ Domain of unknown function (DUF1127) CSC00_1567 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CSC00_1569 ENOG41064T2 transcriptional regulator, lysR family CSC00_1570 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CSC00_1571 ENOG4105CNN ABC, transporter CSC00_1572 ENOG4105CNN ABC, transporter CSC00_1573 ENOG4105C2J ABC transporter CSC00_1574 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CSC00_1576 ENOG4105D0S secretion protein (HlyD CSC00_1577 ENOG4105CJ1 ABC, transporter CSC00_1578 ENOG4105CMI transporter CSC00_1585 ENOG4105EZE Cupin 4 family protein CSC00_1588 ENOG4105GR3 Histidine kinase CSC00_1589 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSC00_1591 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CSC00_1592 ENOG410624V efflux system protein CSC00_1593 ENOG4105EP1 Efflux transporter rnd family, mfp subunit CSC00_1594 ENOG4108IJF Heavy metal efflux pump, CzcA CSC00_1596 ENOG4105QNF Outer membrane lipoprotein CSC00_1597 ENOG4108XDN Transcriptional regulator CSC00_1599 ENOG4107FW0 short-chain dehydrogenase reductase CSC00_1602 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CSC00_1606 ENOG4107SEY Conserved Protein CSC00_1607 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) CSC00_1609 ENOG4105C93 Xylose Isomerase CSC00_1610 ENOG4105CT4 transporter CSC00_1611 ENOG4105DSG hydrolase family 43 CSC00_1619 ENOG4105DQ6 Transposase CSC00_1629 ENOG4105ZTC transcriptional activator, Ogr delta CSC00_1639 ENOG41077A9 carbonic anhydrase CSC00_1640 ENOG4105CHH sulfate transporter CSC00_1641 ENOG4105DQ4 alcohol dehydrogenase CSC00_1643 ENOG4105DRS transport system, permease CSC00_1644 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) CSC00_1645 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CSC00_1646 ENOG4108IJG ABC transporter substrate-binding protein CSC00_1647 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CSC00_1648 ENOG4105F0H myo-inositol catabolism protein CSC00_1650 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) CSC00_1652 ENOG4105D7K pfkb domain protein CSC00_1653 ENOG4105CHC glucokinase (EC 2.7.1.2) CSC00_1655 ENOG4105DH8 myo-inositol catabolism CSC00_1656 ENOG4105C26 Dehydrogenase CSC00_1658 ENOG4105D7A ATP-binding protein CSC00_1659 ENOG4108K5H permease YjgP YjgQ family protein CSC00_1660 ENOG4108M8S permease YjgP YjgQ family protein CSC00_1662 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CSC00_1663 ENOG4105MYG DNA polymerase iii, chi subunit CSC00_1664 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CSC00_1665 ENOG4108MJ3 acetyltransferase CSC00_1666 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase CSC00_1667 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) CSC00_1669 ENOG4105FDP GntR family transcriptional regulator CSC00_1670 ENOG4105CSX c4-dicarboxylate anaerobic carrier CSC00_1671 ENOG4105CI2 imidazolone-5-propionate hydrolase CSC00_1672 ENOG4108KPW sugar kinase CSC00_1673 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine CSC00_1675 ENOG4105XEP YhcH YjgK YiaL family protein CSC00_1677 ENOG4105CXT aspartate transcarbamylase CSC00_1678 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) CSC00_1679 ENOG4105KME endoribonuclease L-psp CSC00_1681 ENOG4105D4X repressor CSC00_1682 ENOG4105C5Y PTS System CSC00_1683 ENOG4105CG3 alpha amylase, catalytic region CSC00_1684 ENOG4105CK1 PTS System CSC00_1685 ENOG4105F8D glycoside hydrolase family 4 CSC00_1688 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CSC00_1689 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) CSC00_1690 ENOG4105K4U addiction module toxin, RelE StbE family CSC00_1692 ENOG4105EMD TRANSCRIPTIONal CSC00_1693 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CSC00_1696 ENOG41069H0 dihydroorotase EC 3.5.2.3 CSC00_1703 ENOG4108XVM Cytochrome b(562) CSC00_1704 ENOG4105CMS peptidase U62, modulator of DNA gyrase CSC00_1705 ENOG4105N42 UPF0307 protein CSC00_1710 ENOG4105DFU Cell wall formation (By similarity) CSC00_1712 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 CSC00_1713 ENOG41062B0 ABC transporter, permease CSC00_1714 ENOG4107R9N ABC transporter CSC00_1715 ENOG4105C2J ABC transporter CSC00_1717 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator CSC00_1718 ENOG4105F0N pyrophosphate phospho-hydrolase CSC00_1721 ENOG4108ZHD aig2 family CSC00_1722 ENOG4105MA0 exported protein CSC00_1723 ENOG4105CFU surface antigen CSC00_1725 ENOG4105C37 (CBS) domain CSC00_1726 ENOG41061GZ Protein of unknown function (DUF1107) CSC00_1727 ENOG4108UUE Transcriptional regulator CSC00_1728 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase CSC00_1729 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic CSC00_1730 ENOG4105KVH Transcriptional regulator CSC00_1731 ENOG4105ECR NmrA family CSC00_1733 ENOG4105DXC membrane CSC00_1734 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) CSC00_1736 ENOG4108V1T peptidylprolyl cis-trans isomerase CSC00_1737 ENOG4105FHY Opacity-associated protein A CSC00_1738 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CSC00_1739 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CSC00_1740 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CSC00_1741 ENOG4105KIT UPF0379 protein yjfY CSC00_1746 ENOG4106ETB IIa component CSC00_1747 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport CSC00_1748 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC CSC00_1751 ENOG4108MXZ Esterase CSC00_1752 ENOG4105WSB biofilm stress and motility protein A CSC00_1753 ENOG4105S17 UPF0379 protein yjfN CSC00_1754 ENOG4105CSU acyl-Coa dehydrogenase CSC00_1755 ENOG4105C2N RNA methyltransferase TrmH family group 3 CSC00_1756 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CSC00_1758 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CSC00_1762 ENOG4105EPW hflc protein CSC00_1763 ENOG4107QJR hflk protein CSC00_1764 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CSC00_1765 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CSC00_1767 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CSC00_1768 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CSC00_1769 ENOG4105K8N protein family UPF0079, ATPase CSC00_1770 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CSC00_1771 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CSC00_1776 ENOG4106TNF Periplasmic binding protein CSC00_1777 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) CSC00_1778 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CSC00_1779 ENOG4105DJ4 phosphatidylserine decarboxylase CSC00_1780 ENOG4105EGS Mechanosensitive ion channel CSC00_1781 ENOG4107SC7 Inner membrane transporter yjeM CSC00_1782 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) CSC00_1783 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) CSC00_1784 ENOG4105E33 succinate dehydrogenase CSC00_1788 ENOG4105KPY Small multidrug resistance protein CSC00_1789 ENOG4106BSU Entericidin B CSC00_1792 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CSC00_1794 ENOG4105F2I Transposase CSC00_1797 ENOG4105CW0 outer membrane usher protein CSC00_1801 ENOG4108MBX Secretion Protein CSC00_1802 ENOG4108JJA ABC, transporter CSC00_1804 ENOG4108ZVF (LipO)protein CSC00_1805 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CSC00_1808 ENOG4105DVH amino acid CSC00_1809 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 CSC00_1811 ENOG4108IJ0 Aspartate ammonia-lyase CSC00_1812 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CSC00_1814 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) CSC00_1815 ENOG4108SIC Transcriptional regulator CSC00_1819 ENOG4105DQ6 Transposase CSC00_1824 ENOG4108TUY outer membrane protein PgaA CSC00_1825 ENOG4107BJW polysaccharide deacetylase CSC00_1826 ENOG4105CND Glycosyl transferase, family 2 CSC00_1829 ENOG4108ZCF integral membrane protein CSC00_1831 ENOG4105DVC DnaJ domain protein CSC00_1834 ENOG4105DQ6 Transposase CSC00_1838 ENOG4105CT4 transporter CSC00_1839 ENOG4105F8D glycoside hydrolase family 4 CSC00_1840 ENOG4108K2B transcriptional regulator CSC00_1841 ENOG4105CSH Transporter CSC00_1842 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CSC00_1843 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase CSC00_1844 ENOG4107RJJ Transcriptional regulator CSC00_1845 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG CSC00_1846 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH CSC00_1847 ENOG4105EKV Phosphonate metabolism protein CSC00_1848 ENOG4105FT8 Phosphonate metabolism CSC00_1849 ENOG4105ENV phosphonate C-P lyase system protein PhnK CSC00_1850 ENOG4105HRV phosphonate c-p lyase system protein phnl CSC00_1851 ENOG4105FD8 phosphonate metabolism protein PhnM CSC00_1852 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) CSC00_1853 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein CSC00_1855 ENOG4105BZU Histidine kinase CSC00_1856 ENOG4105C2J ABC transporter CSC00_1857 ENOG4105CNN ABC, transporter CSC00_1858 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CSC00_1863 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CSC00_1864 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CSC00_1865 ENOG41082ND Uncharacterized protein yjcO CSC00_1866 ENOG4105CK2 sodium dicarboxylate symporter CSC00_1868 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CSC00_1869 ENOG41062QD Membrane CSC00_1873 ENOG4105CW0 outer membrane usher protein CSC00_1874 ENOG4108VCD Chaperone CSC00_1875 ENOG4105MX3 Fimbrial CSC00_1877 ENOG41067MG lrgb family CSC00_1879 ENOG4105CMU LysR family (Transcriptional regulator CSC00_1880 ENOG4105EEQ Na H antiporter CSC00_1881 ENOG4105C7N Xanthine uracil vitamin C permease CSC00_1882 ENOG4108K3A Glutathione S-transferase CSC00_1883 ENOG4108Z4X TRANSCRIPTIONal CSC00_1884 ENOG4108W3Q Transcriptional regulator CSC00_1885 ENOG4108M8H domain protein CSC00_1887 ENOG4105PMV Membrane CSC00_1892 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CSC00_1893 ENOG4105ETE Transcriptional regulator (LacI family CSC00_1894 ENOG4105ECY inositol monophosphatase CSC00_1896 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CSC00_1900 ENOG4108DMH HTH_ARAC CSC00_1901 ENOG4107RNH Outer membrane receptor FepA CSC00_1903 ENOG4105E4C Lytic transglycosylase catalytic CSC00_1904 ENOG4108UUM single-stranded DNA-binding protein CSC00_1905 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CSC00_1906 ENOG4105MSB protein, conserved in bacteria CSC00_1907 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme CSC00_1909 ENOG4105CGF Aromatic amino acid aminotransferase CSC00_1910 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CSC00_1911 ENOG4105CDU Replicative dna helicase CSC00_1912 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CSC00_1913 ENOG4105P4Z Phage shock protein G CSC00_1914 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CSC00_1917 ENOG4105MYN Zinc uptake regulation protein CSC00_1918 ENOG4105VDW Csbd family CSC00_1920 ENOG4107R73 Mate efflux family protein CSC00_1921 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CSC00_1922 ENOG41080IJ Diacylglycerol kinase CSC00_1923 ENOG4105E55 glycerol-3-phosphate acyltransferase CSC00_1924 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) CSC00_1925 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) CSC00_1926 ENOG4107W52 maltose operon periplasmic protein CSC00_1927 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) CSC00_1929 ENOG4107FKK extracellular solute-binding protein family 1 CSC00_1930 ENOG4105D56 permease protein CSC00_1931 ENOG4105EG2 ABC transporter, permease CSC00_1932 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CSC00_1933 ENOG4105CEM UPF0597 protein CSC00_1937 ENOG4105KME endoribonuclease L-psp CSC00_1939 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CSC00_1940 ENOG4107QP8 phosphohexose isomerase CSC00_1941 ENOG4105CFH Aspartokinase CSC00_1942 ENOG4105C09 Bile acid CSC00_1943 ENOG4108ZR5 Conserved Protein CSC00_1944 ENOG4105FE9 pseudouridine synthase CSC00_1945 ENOG4105DKT Transcriptional regulator CSC00_1946 ENOG4105CHR reductase CSC00_1947 ENOG4108XCU pts system CSC00_1948 ENOG4105KPI PTS system sorbose subfamily IIB component CSC00_1949 ENOG4105ETZ PTS System CSC00_1950 ENOG4105F3R pts system mannose fructose sorbose family iid CSC00_1951 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein CSC00_1952 ENOG4105F9E Shikimate 5-dehydrogenase CSC00_1953 ENOG4105EAM Na Pi-cotransporter CSC00_1954 ENOG4105C3R Methionine synthase CSC00_1955 ENOG41069M3 Transcriptional regulator CSC00_1956 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) CSC00_1957 ENOG4108I9X Isocitrate lyase CSC00_1958 ENOG4107QP3 malate synthase g CSC00_1959 ENOG4105CVG Homoserine O-transsuccinylase CSC00_1960 ENOG4105K5X acetyltransferase CSC00_1965 ENOG4105DC1 bifunctional purine biosynthesis protein purh CSC00_1966 ENOG4105C12 Phosphoribosylglycinamide synthetase CSC00_1968 ENOG4105BZU Histidine kinase CSC00_1969 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism CSC00_1970 ENOG4108T8B Protein of unknown function (DUF1481) CSC00_1971 ENOG4105K70 DNA-binding protein CSC00_1972 ENOG4105R2J Conserved Protein CSC00_1973 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) CSC00_1974 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CSC00_1975 ENOG4105E09 nadh pyrophosphatase CSC00_1976 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) CSC00_1977 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CSC00_1978 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CSC00_1979 ENOG4105D06 uba thif-type nad fad binding protein CSC00_1980 ENOG4105WHD thiamine biosynthesis protein ThiS CSC00_1981 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CSC00_1982 ENOG4105D41 biosynthesis protein thiH CSC00_1984 ENOG4106TD9 Diguanylate cyclase CSC00_1986 ENOG4105VCP PTS System CSC00_1987 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CSC00_1988 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CSC00_1989 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CSC00_1992 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CSC00_1993 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CSC00_1994 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CSC00_1995 ENOG4105PM1 preprotein translocase subunit SecE CSC00_1996 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CSC00_2001 ENOG4105CS9 pantothenic acid kinase CSC00_2002 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CSC00_2003 ENOG4105D4A Cell wall formation (By similarity) CSC00_2009 ENOG4108RR8 protoporphyrinogen oxidase CSC00_2010 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) CSC00_2011 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CSC00_2012 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) CSC00_2013 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) CSC00_2014 ENOG4105CHU acetyl-coa acetyltransferase CSC00_2015 ENOG4107QK7 reductase CSC00_2016 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CSC00_2018 ENOG4105MDZ Transcriptional activator rfaH CSC00_2020 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CSC00_2022 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CSC00_2023 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) CSC00_2024 ENOG4105JC1 sterol-binding domain protein CSC00_2025 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CSC00_2026 ENOG4105CGY Dna recombination protein CSC00_2027 ENOG4107SXA Phosphorylase CSC00_2028 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) CSC00_2029 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CSC00_2030 ENOG4105EMK carboxylate amino acid amine transporter CSC00_2031 ENOG4105DQF Hydrolase CSC00_2032 ENOG4108EUD Lysophospholipase CSC00_2036 ENOG4105C9U ATP-dependent DNA helicase RecQ CSC00_2037 ENOG4105HDD phospholipase CSC00_2038 ENOG4108VUY thioesterase Superfamily protein CSC00_2039 ENOG4105FR1 rard protein CSC00_2040 ENOG4107QUT magnesium and cobalt transport protein CorA CSC00_2042 ENOG4105C4R Atp-dependent dna helicase CSC00_2043 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant CSC00_2044 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CSC00_2045 ENOG4105CT0 Protein of unknown function, DUF484 CSC00_2047 ENOG4105S7Z (LipO)protein CSC00_2048 ENOG4105XQ6 frataxin-like protein CSC00_2049 ENOG4107T0K Adenylate cyclase CSC00_2050 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CSC00_2051 ENOG41076E6 Uroporphyrinogen-III Synthase CSC00_2052 ENOG4105ECF c-methyltransferase CSC00_2053 ENOG410601J HemY protein CSC00_2059 ENOG4105C85 amino acid CSC00_2060 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family CSC00_2061 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) CSC00_2062 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) CSC00_2063 ENOG4105EGZ biosynthesis protein CSC00_2064 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CSC00_2065 ENOG4108WJ1 acetyltransferase CSC00_2066 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CSC00_2067 ENOG4105C1B dTDP-glucose 4-6-dehydratase CSC00_2068 ENOG4108IJ1 Dehydrogenase CSC00_2069 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CSC00_2070 ENOG4105SFE lipopolysaccharide biosynthesis protein CSC00_2071 ENOG4105ESV Glycosyl transferase, family 4 CSC00_2073 ENOG4105K63 Thioredoxin CSC00_2074 ENOG4105C1J atp-dependent rna helicase CSC00_2075 ENOG4105C9X ppx gppa phosphatase CSC00_2077 ENOG4105F2I Transposase CSC00_2078 ENOG4108UQV Membrane CSC00_2079 ENOG4105C4R Atp-dependent dna helicase CSC00_2080 ENOG4105KQ5 peptidylprolyl cis-trans isomerase CSC00_2081 ENOG4105KQ5 peptidylprolyl cis-trans isomerase CSC00_2083 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CSC00_2084 ENOG4105EMY transcriptional regulator CSC00_2085 ENOG4105C7B Threonine dehydratase CSC00_2086 ENOG4105C01 Dihydroxy-acid dehydratase CSC00_2087 ENOG4105CM2 brancheD-chain amino acid aminotransferase CSC00_2088 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit CSC00_2091 ENOG4105C0P Mg chelatase subunit ChlI CSC00_2092 ENOG4108WFC UPF0438 protein yifE CSC00_2103 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) CSC00_2104 ENOG4108Y73 Membrane CSC00_2105 ENOG4105EJ2 Transcriptional regulator CSC00_2106 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) CSC00_2107 ENOG4105C5Q Transcriptional regulator CSC00_2108 ENOG4105CH7 arginosuccinase CSC00_2109 ENOG4105CAS nag kinase CSC00_2110 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CSC00_2113 ENOG4108MEK Metal-binding protein YodA CSC00_2114 ENOG4106R3P AraC family transcriptional regulator CSC00_2115 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CSC00_2116 ENOG4105DCT glycerol dehydrogenase CSC00_2117 ENOG4108Q5Y Membrane CSC00_2118 ENOG4105SYT Methylenetetrahydrofolate reductase CSC00_2119 ENOG4105CN8 Transcriptional regulator CSC00_2120 ENOG4108Z8I decarboxylase CSC00_2121 ENOG4105CGH 5'-nucleotidase CSC00_2123 ENOG4105CFH Aspartokinase CSC00_2124 ENOG4105C28 cystathionine CSC00_2125 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) CSC00_2127 ENOG4105C25 Primosomal protein n' CSC00_2128 ENOG4105ETE Transcriptional regulator (LacI family CSC00_2129 ENOG41063M6 Cell Division Protein CSC00_2132 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CSC00_2135 ENOG41076HS cation diffusion facilitator family transporter CSC00_2136 ENOG4105FMW periplasmic CSC00_2137 ENOG4105E3W Two component transcriptional regulator (Winged helix family CSC00_2138 ENOG4105E0F Histidine kinase CSC00_2139 ENOG4108RPX mosc domain containing protein CSC00_2140 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CSC00_2141 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) CSC00_2142 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) CSC00_2143 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) CSC00_2144 ENOG4105DET Rhamnulokinase CSC00_2145 ENOG4105DKG l-rhamnose isomerase CSC00_2146 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) CSC00_2147 ENOG4105D4B ABC, transporter CSC00_2148 ENOG4105C2J ABC transporter CSC00_2149 ENOG4105CNN ABC, transporter CSC00_2150 ENOG4105CNN ABC, transporter CSC00_2151 ENOG4105C0A alcohol dehydrogenase CSC00_2153 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) CSC00_2162 ENOG4105D2N Aldolase CSC00_2165 ENOG4105CTQ phosphohexokinase CSC00_2167 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CSC00_2168 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CSC00_2169 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CSC00_2170 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CSC00_2171 ENOG4108MG3 formate dehydrogenase CSC00_2174 ENOG41068KX affects formate dehydrogenase-N CSC00_2176 ENOG4105SUU thioesterase domain CSC00_2177 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CSC00_2178 ENOG4107S2Z UPF0761 membrane protein CSC00_2179 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 CSC00_2182 ENOG4105C5F glutamine synthetase CSC00_2183 ENOG4105CUX Signal transduction histidine kinase CSC00_2184 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CSC00_2185 ENOG4105D4P Coproporphyrinogen iii oxidase CSC00_2186 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) CSC00_2187 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CSC00_2189 ENOG4105C2M dna polymerase I CSC00_2190 ENOG4106HNH Acyl-transferase CSC00_2192 ENOG4105E27 serine threonine protein kinase CSC00_2193 ENOG4105PC1 Conserved Protein CSC00_2194 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CSC00_2195 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b CSC00_2200 ENOG4107EJG GntR family transcriptional regulator CSC00_2201 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSC00_2202 ENOG4105ETE Transcriptional regulator (LacI family CSC00_2203 ENOG4108RVA ribokinase CSC00_2204 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CSC00_2205 ENOG4105CNN ABC, transporter CSC00_2206 ENOG4105C2J ABC transporter CSC00_2208 ENOG4105DFH Transport of potassium into the cell (By similarity) CSC00_2211 ENOG4105CU9 asparagine synthetase A CSC00_2212 ENOG4108VVK transcriptional Regulator, AsnC CSC00_2213 ENOG4105QTB Flavodoxin CSC00_2214 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CSC00_2215 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CSC00_2216 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation CSC00_2218 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CSC00_2220 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CSC00_2221 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CSC00_2222 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CSC00_2223 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CSC00_2224 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CSC00_2227 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CSC00_2228 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CSC00_2229 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) CSC00_2230 ENOG4105C8U phosphate abc transporter CSC00_2231 ENOG4105E2Z phosphate ABC transporter (Permease CSC00_2232 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CSC00_2235 ENOG4108P68 Outer membrane porin CSC00_2236 ENOG4105DYC esterase CSC00_2237 ENOG4107VKM 6-phosphogluconolactonase CSC00_2238 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 CSC00_2240 ENOG4105C7N Xanthine uracil vitamin C permease CSC00_2241 ENOG4108YYH Nadph-dependent fmn reductase CSC00_2242 ENOG4105E8Q phosphopantetheinyl transferase CSC00_2244 ENOG4105C2C drug resistance transporter, Bcr CflA CSC00_2246 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CSC00_2247 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CSC00_2251 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CSC00_2252 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CSC00_2253 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CSC00_2254 ENOG410667J hydrolase CSC00_2257 ENOG4105EMF GntR family transcriptional regulator CSC00_2258 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 CSC00_2259 ENOG4108RTU Aldolase CSC00_2260 ENOG4105CXK mandelate racemase muconate lactonizing CSC00_2262 ENOG4105DJB Major Facilitator Superfamily CSC00_2263 ENOG4105D99 atp gtp-binding protein CSC00_2264 ENOG4105R2A (LipO)protein CSC00_2267 ENOG4105F5P DNA-damage-inducible protein d CSC00_2268 ENOG4105D0C transport protein CSC00_2269 ENOG4105FDP GntR family transcriptional regulator CSC00_2270 ENOG4105CI1 PTS System CSC00_2271 ENOG4105F8D glycoside hydrolase family 4 CSC00_2272 ENOG4105VG5 Membrane CSC00_2273 ENOG4105JP4 Inner membrane protein yidG CSC00_2277 ENOG4105W8I Transcriptional regulator CSC00_2278 ENOG4105E5M Multidrug resistance protein D CSC00_2282 ENOG4105C7K acetolactate synthase CSC00_2283 ENOG4105M71 acetolactate synthase 1 regulatory subunit CSC00_2284 ENOG4108KX4 response regulator CSC00_2285 ENOG4105BZU Histidine kinase CSC00_2286 ENOG4105CXY transporter CSC00_2287 ENOG4105CXY transporter CSC00_2288 ENOG4108SAJ Protein of unknown function (DUF1198) CSC00_2292 ENOG4108KAZ Involved in phosphonate degradation (By similarity) CSC00_2293 ENOG4107STF Involved in phosphonate degradation (By similarity) CSC00_2294 ENOG4106S9K Transcriptional regulator CSC00_2297 ENOG4108MP3 ABC transporter, permease CSC00_2300 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) CSC00_2301 ENOG4105VCP PTS System CSC00_2302 ENOG4105CK1 PTS System CSC00_2304 ENOG4105ETE Transcriptional regulator (LacI family CSC00_2305 ENOG4105D2S major facilitator superfamily CSC00_2307 ENOG4107F9Y LysR family transcriptional regulator CSC00_2309 ENOG4105JSC dimethylmenaquinone methyltransferase CSC00_2312 ENOG4105T8A Uncharacterized protein YicS CSC00_2313 ENOG4108UZ3 Transporter CSC00_2314 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) CSC00_2315 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CSC00_2316 ENOG4105C2C drug resistance transporter, Bcr CflA CSC00_2317 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CSC00_2318 ENOG4105BZS acriflavin resistance protein CSC00_2319 ENOG4105C1P efflux transporter, rnd family, mfp subunit CSC00_2325 ENOG410630P Transcriptional regulator CSC00_2327 ENOG4105CR8 Transcriptional regulator CSC00_2332 ENOG4105D01 (LipO)protein CSC00_2335 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein CSC00_2337 ENOG4105DQ4 alcohol dehydrogenase CSC00_2341 ENOG4105NI3 Protein of unknown function (DUF3237) CSC00_2343 ENOG4105CT4 transporter CSC00_2344 ENOG4105CJQ hydrolase, family 31 CSC00_2346 ENOG4105F8D glycoside hydrolase family 4 CSC00_2347 ENOG4105CI1 PTS System CSC00_2348 ENOG4105JV1 AsmA family CSC00_2349 ENOG4105C2W permease CSC00_2351 ENOG4105D6U Sodium Glutamate Symporter CSC00_2352 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CSC00_2353 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CSC00_2354 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) CSC00_2355 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CSC00_2358 ENOG4105CP7 Triose-phosphate isomerase CSC00_2359 ENOG4105EBK exported protein CSC00_2360 ENOG4108VTS Membrane CSC00_2361 ENOG4105DP0 ferredoxin-NADP reductase CSC00_2362 ENOG4105CBT Fructose-1,6-bisphosphatase CSC00_2363 ENOG4105CB5 ATP-dependent DNA helicase recG CSC00_2364 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase CSC00_2365 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CSC00_2366 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) CSC00_2367 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CSC00_2368 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) CSC00_2369 ENOG4105EN6 Membrane CSC00_2371 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CSC00_2372 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) CSC00_2374 ENOG4105DSJ YicC domain protein CSC00_2379 ENOG4105CJ1 ABC, transporter CSC00_2380 ENOG4105F2I Transposase CSC00_2382 ENOG4107QWP ABC-2 type transporter CSC00_2385 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CSC00_2386 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CSC00_2387 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CSC00_2388 ENOG4105W5Q DNA repair protein (RadC CSC00_2391 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CSC00_2392 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CSC00_2393 ENOG4106WTF Glycosyl transferase, family 2 CSC00_2394 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase CSC00_2395 ENOG4105K64 Glycosyl transferase, family 2 CSC00_2396 ENOG4105CPK Glycosyl transferase (Group 1 CSC00_2398 ENOG4105DKP glycosyl transferase, family 9 CSC00_2403 ENOG4105D16 lipopolysaccharide heptosyltransferase i CSC00_2404 ENOG4105XA0 heptosyltransferase ii CSC00_2405 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CSC00_2406 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CSC00_2407 ENOG4105CPQ Dehydrogenase CSC00_2409 ENOG4105PXI polysaccharide deacetylase CSC00_2410 ENOG41063SB peptidase CSC00_2412 ENOG4107YZP Rhodanese domain protein CSC00_2413 ENOG4105VW4 glutaredoxin 3 CSC00_2415 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CSC00_2416 ENOG4105D7W serine acetyltransferase CSC00_2417 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CSC00_2418 ENOG4105DMF Dehydrogenase CSC00_2419 ENOG41073TP transcriptional regulator CSC00_2420 ENOG4105DAA L-lactate CSC00_2421 ENOG4108YYI Protein of unknown function (DUF2810) CSC00_2423 ENOG4105E61 Mannitol repressor protein CSC00_2424 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase CSC00_2425 ENOG4105CTS PTS system mannitol-specific CSC00_2426 ENOG4105FP6 Protein of unknown function (DUF3302) CSC00_2427 ENOG4105EFX secretion protein, HlyD family CSC00_2428 ENOG4108U78 Glutathione S-transferase CSC00_2429 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) CSC00_2430 ENOG4105EM7 Selenocysteine-specific translation elongation factor CSC00_2431 ENOG4108RC0 Electron transport protein CSC00_2432 ENOG4105JKW Valine--pyruvate aminotransferase CSC00_2433 ENOG4107T9C Alpha amylase catalytic region CSC00_2434 ENOG4108UR8 BAX protein CSC00_2435 ENOG4105T16 Transcriptional regulator (AraC family) CSC00_2436 ENOG4107RNG ABC transporter CSC00_2437 ENOG4105C2J ABC transporter CSC00_2438 ENOG4105DFW ABC transporter CSC00_2439 ENOG4105C93 Xylose Isomerase CSC00_2440 ENOG4105CMG Carbohydrate kinase CSC00_2441 ENOG410688U Inner membrane protein yiaB CSC00_2442 ENOG4108Z12 YiaAB two helix domain-containing protein CSC00_2443 ENOG4105MEV Acyl-transferase CSC00_2445 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit CSC00_2446 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CSC00_2448 ENOG41060TC Hok gef cell toxic protein CSC00_2450 ENOG4105VEQ Cold shock protein CSC00_2451 ENOG4105MVF Transcriptional regulator CSC00_2452 ENOG4105D2S major facilitator superfamily CSC00_2453 ENOG4106JH6 (LipO)protein CSC00_2454 ENOG4105C5I Dehydrogenase CSC00_2456 ENOG4105D7K pfkb domain protein CSC00_2458 ENOG4108M60 Transcriptional regulator CSC00_2460 ENOG4108ZG0 Ompa motb domain protein CSC00_2461 ENOG4107QY8 reductase CSC00_2462 ENOG4105HNP -acetyltransferase CSC00_2463 ENOG4108R3E Dna-3-methyladenine glycosylase i CSC00_2464 ENOG4105EAX Putative lipase CSC00_2465 ENOG4105FCD Major Facilitator CSC00_2466 ENOG4105DIJ Phosphoethanolamine transferase CSC00_2470 ENOG4105DQ6 Transposase CSC00_2471 ENOG4105DEF Extracellular solute-binding protein, family 5 CSC00_2472 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSC00_2473 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSC00_2474 ENOG4105C3U ABC transporter CSC00_2475 ENOG4108JQ7 (ABC) transporter CSC00_2479 ENOG4107QZ7 Cellulose synthase catalytic subunit CSC00_2480 ENOG4107EEX Cellulose synthase regulator protein CSC00_2481 ENOG4105EJG cellulose synthase CSC00_2484 ENOG4105D1V cellulose synthase operon protein YhjU CSC00_2485 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT CSC00_2486 ENOG4105U74 cellulose biosynthesis protein BcsE CSC00_2487 ENOG410661M cytoplasmic protein CSC00_2488 ENOG4105UTS cellulose synthase operon protein YhjQ CSC00_2489 ENOG4107QZ7 Cellulose synthase catalytic subunit CSC00_2490 ENOG4107EEX Cellulose synthase regulator protein CSC00_2491 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) CSC00_2492 ENOG4105EJG cellulose synthase CSC00_2494 ENOG4105BZU Histidine kinase CSC00_2495 ENOG4105CK2 sodium dicarboxylate symporter CSC00_2496 ENOG4105CS0 peptidase CSC00_2499 ENOG41066T0 asmA family CSC00_2500 ENOG4105CSH Transporter CSC00_2501 ENOG4107H3J ribonuclease CSC00_2502 ENOG4105CBN LysR family transcriptional regulator CSC00_2503 ENOG4105CHR reductase CSC00_2506 ENOG4105C0A alcohol dehydrogenase CSC00_2508 ENOG4105DC8 reductase CSC00_2509 ENOG4105D6S protein involved in catabolism of external DNA CSC00_2510 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CSC00_2511 ENOG4105DGW oligopeptidase A CSC00_2512 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) CSC00_2513 ENOG4105DUX Transporter CSC00_2514 ENOG4108M6U Universal stress protein A CSC00_2516 ENOG4105CJ3 phosphate transporter CSC00_2517 ENOG4105CBX hi0933 family CSC00_2518 ENOG4105CJW magnesium transporter CSC00_2520 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) CSC00_2522 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSC00_2523 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSC00_2524 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CSC00_2526 ENOG4105PY6 Phenolic acid decarboxylase CSC00_2527 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CSC00_2528 ENOG4105CKK Glycosyl transferase, family 2 CSC00_2529 ENOG4105C3I Nad-dependent epimerase dehydratase CSC00_2530 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) CSC00_2531 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) CSC00_2532 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CSC00_2533 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CSC00_2534 ENOG4105DSF transport protein CSC00_2535 ENOG4105F9N Major Facilitator Superfamily CSC00_2536 ENOG4108W1V Lipoprotein CSC00_2537 ENOG4105EX9 Membrane CSC00_2540 ENOG4107FS9 Membrane CSC00_2542 ENOG4105MG3 Membrane CSC00_2543 ENOG4106H78 methyltransferase CSC00_2544 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CSC00_2545 ENOG4105CAK Cell division ATP-binding protein ftsE CSC00_2546 ENOG4105CRP Part of the ABC transporter FtsEX involved in CSC00_2547 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSC00_2549 ENOG4108JPW Aminotransferase CSC00_2552 ENOG4105CP9 extracellular ligand-binding receptor CSC00_2553 ENOG4105U59 -acetyltransferase CSC00_2556 ENOG4105CP9 extracellular ligand-binding receptor CSC00_2557 ENOG4105C32 Amino acid ABC transporter (Permease) CSC00_2558 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CSC00_2559 ENOG4105C0Z ABC transporter CSC00_2560 ENOG4108IV0 ABC, transporter CSC00_2561 ENOG41060M8 Pfam:PhdYeFM CSC00_2563 ENOG4105BZ7 extracellular solute-binding protein family 1 CSC00_2564 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component CSC00_2567 ENOG4107T6V glycerophosphoryl diester phosphodiesterase CSC00_2568 ENOG4105WC8 Conserved Protein CSC00_2569 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CSC00_2570 ENOG4105WCN acetyltransferase CSC00_2572 ENOG4105D9R oxidoreductase CSC00_2573 ENOG4105C2I pirin domain protein CSC00_2574 ENOG4105DIQ Transcriptional regulator CSC00_2575 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CSC00_2576 ENOG4105C6Z Gluconate CSC00_2578 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CSC00_2579 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CSC00_2580 ENOG4108IUM Glycogen debranching enzyme CSC00_2581 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CSC00_2582 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) CSC00_2583 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CSC00_2585 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CSC00_2586 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) CSC00_2587 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) CSC00_2588 ENOG4105E98 transcriptional regulator DeoR family CSC00_2589 ENOG41061ZR Transcriptional regulator CSC00_2591 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CSC00_2592 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) CSC00_2593 ENOG4105C6Z Gluconate CSC00_2595 ENOG4105MJ2 Competence protein CSC00_2596 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CSC00_2598 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) CSC00_2599 ENOG4105CE1 Ferrous iron transport protein b CSC00_2600 ENOG4105XFK Ferrous iron transport protein A CSC00_2601 ENOG4105BZM domain protein CSC00_2602 ENOG4108RRZ Transcription elongation factor GreB CSC00_2603 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CSC00_2604 ENOG4105E0F Histidine kinase CSC00_2608 ENOG4105VEJ Heat shock protein CSC00_2609 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 CSC00_2610 ENOG4105DQY intracellular growth attenuator CSC00_2611 ENOG4107RK2 ADP-ribose diphosphatase NudE CSC00_2612 ENOG4108JQC penicillin-binding protein 1A CSC00_2617 ENOG4105E4G Type IV pilus CSC00_2618 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CSC00_2619 ENOG4105D49 3-dehydroquinate synthase CSC00_2620 ENOG4105EGB membrane protein DamX CSC00_2621 ENOG4105DFE Dna adenine methylase CSC00_2622 ENOG4105DJV ribulose-phosphate 3-epimerase CSC00_2624 ENOG4105C31 Tryptophanyl-tRNA synthetase CSC00_2625 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CSC00_2626 ENOG4105WZK nitrite reductase NADPH small subunit CSC00_2627 ENOG4107QZF nitrite reductase NADPH large subunit CSC00_2629 ENOG4105DZC cytosine deaminase CSC00_2630 ENOG4106DTQ Protein TsgA homolog CSC00_2631 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CSC00_2632 ENOG4106195 uncharacterized protein yhfG CSC00_2633 ENOG4105MZU cell filamentation protein CSC00_2635 ENOG4105C8Y Acetylornithine aminotransferase CSC00_2636 ENOG410613R integral membrane protein, YccS YhfK family CSC00_2638 ENOG4108UKZ OsmC family CSC00_2639 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) CSC00_2641 ENOG4105DNZ Alpha Beta Hydrolase CSC00_2642 ENOG4105C5H ABC transporter CSC00_2643 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CSC00_2644 ENOG4105CKD glutathione-regulated potassium-efflux system protein CSC00_2645 ENOG4105VKU nucleicacid-binding protein CSC00_2646 ENOG4108YZY peptidylprolyl cis-trans isomerase CSC00_2648 ENOG4108V1T peptidylprolyl cis-trans isomerase CSC00_2649 ENOG4105WWK YheO domain protein CSC00_2650 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) CSC00_2651 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) CSC00_2652 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) CSC00_2654 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CSC00_2655 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CSC00_2656 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CSC00_2657 ENOG4105W53 bacterioferritin-associated ferredoxin CSC00_2658 ENOG4108UQY Iron-storage protein CSC00_2662 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CSC00_2666 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CSC00_2668 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CSC00_2669 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CSC00_2671 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CSC00_2672 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CSC00_2673 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CSC00_2676 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CSC00_2677 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CSC00_2678 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CSC00_2679 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CSC00_2680 ENOG4105VPB 50S ribosomal protein L30 CSC00_2682 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CSC00_2684 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CSC00_2686 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CSC00_2688 ENOG4105VTS DnaJ-like, subfamily C CSC00_2689 ENOG4105W1Y Transcriptional regulator CSC00_2691 ENOG4105C1A potassium transporter peripheral membrane CSC00_2692 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CSC00_2693 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CSC00_2694 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CSC00_2695 ENOG4105C79 DNA protecting protein DprA CSC00_2697 ENOG4108WI1 Dna topoisomerase CSC00_2698 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CSC00_2699 ENOG4105E2X shikimate dehydrogenase CSC00_2700 ENOG4105SG3 Protein of unknown function (DUF1488) CSC00_2701 ENOG4108Z0R Transferase CSC00_2707 ENOG4105XCM membrane LIPOPROTEIN CSC00_2708 ENOG4105BZS acriflavin resistance protein CSC00_2709 ENOG4105C1P efflux transporter, rnd family, mfp subunit CSC00_2710 ENOG4108XG4 DNA-binding transcriptional regulator CSC00_2711 ENOG4105DFP Integrase CSC00_2714 ENOG4105XB7 anti-repressor protein CSC00_2733 ENOG4105CAR Terminase, large subunit CSC00_2735 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) CSC00_2736 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CSC00_2738 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CSC00_2739 ENOG4108IA2 Sodium pantothenate symporter CSC00_2740 ENOG4105RG0 Membrane CSC00_2741 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CSC00_2742 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CSC00_2744 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) CSC00_2745 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) CSC00_2747 ENOG41062P1 Diguanylate cyclase phosphodiesterase CSC00_2748 ENOG4105DFF Rod shape-determining protein mreb CSC00_2749 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CSC00_2750 ENOG4105VQ7 Rod shape-determining protein MreD CSC00_2752 ENOG4105C03 ribonuclease CSC00_2753 ENOG4105QD6 exported protein CSC00_2754 ENOG4105D1U peptidase U62 modulator of DNA gyrase CSC00_2755 ENOG4105CR8 Transcriptional regulator CSC00_2758 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) CSC00_2759 ENOG4105UNR (Barnase) inhibitor CSC00_2760 ENOG4105RID UPF0379 protein yhcN CSC00_2761 ENOG4105RID UPF0379 protein yhcN CSC00_2763 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CSC00_2764 ENOG4105C0H protease CSC00_2765 ENOG4105C0H protease CSC00_2766 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III CSC00_2767 ENOG4105D6Z AFG1 family ATPase CSC00_2769 ENOG4108UJD 30S ribosomal protein S9 CSC00_2770 ENOG4107MKT Stringent starvation protein a CSC00_2771 ENOG4105KB2 stringent starvation protein b CSC00_2772 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) CSC00_2773 ENOG4105BZ8 glutamate synthase CSC00_2774 ENOG4105CBC glutamate synthase CSC00_2775 ENOG4105N5T Radical SAM Protein CSC00_2776 ENOG4108I5G Major Facilitator superfamily CSC00_2777 ENOG4105CPQ Dehydrogenase CSC00_2779 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CSC00_2780 ENOG4105BZU Histidine kinase CSC00_2781 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain CSC00_2783 ENOG41080Z8 PHOSPHOCARRIER protein CSC00_2785 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN CSC00_2786 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA CSC00_2787 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSC00_2788 ENOG4108IUZ ABC transporter CSC00_2789 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA CSC00_2790 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) CSC00_2791 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase CSC00_2792 ENOG4105C2X Arabinose 5-phosphate isomerase CSC00_2793 ENOG4105FEU K -dependent Na -Ca exchanger CSC00_2794 ENOG4105DHJ ABC, transporter CSC00_2795 ENOG4105CY3 ABC transporter, permease CSC00_2796 ENOG4107PE3 Mammalian cell entry related domain protein CSC00_2797 ENOG4105E3I toluene tolerance CSC00_2798 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane CSC00_2799 ENOG4105VFK BolA family CSC00_2800 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CSC00_2801 ENOG4105HVQ Regulatory factor of maltose metabolism CSC00_2802 ENOG4105EAH synthase CSC00_2805 ENOG4105QYV Membrane CSC00_2806 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CSC00_2807 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase CSC00_2808 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CSC00_2809 ENOG4105HBR Rna-binding protein CSC00_2810 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) CSC00_2811 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CSC00_2812 ENOG4105EEI dihydropteroate synthase CSC00_2817 ENOG4108UII YfaZ family CSC00_2819 ENOG4108PNB DNA-binding transcriptional regulator CSC00_2820 ENOG4105CDH Citrulline--aspartate ligase CSC00_2824 ENOG4105CHV Transcription elongation factor NusA CSC00_2825 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CSC00_2827 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CSC00_2828 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CSC00_2830 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CSC00_2832 ENOG4105C1J atp-dependent rna helicase CSC00_2833 ENOG4105CIC tryptophan-specific transport protein CSC00_2834 ENOG4105DEN Luciferase family CSC00_2835 ENOG4106RZ4 Peptidase U32 CSC00_2836 ENOG4105CFP Peptidase U32 CSC00_2837 ENOG4105XPQ lipid carrier protein CSC00_2838 ENOG4108YYD acetyltransferase CSC00_2839 ENOG41082IR Excinuclease ABC C subunit domain protein CSC00_2840 ENOG4108ZPB UPF0306 protein CSC00_2841 ENOG4107R7Y intracellular protease Pfpi family CSC00_2842 ENOG4105K4T epimerase CSC00_2843 ENOG4107S21 permease CSC00_2844 ENOG4105W4M Transport-associated protein CSC00_2846 ENOG41082RQ UPF0102 protein CSC00_2847 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) CSC00_2848 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CSC00_2849 ENOG4107R3N Filamentation induced by cAMP protein fic CSC00_2851 ENOG4107WTH Galactitol-1-phosphate dehydrogenase CSC00_2852 ENOG4105DT3 PTS system, galactitol-specific IIc component CSC00_2853 ENOG41090UW PTS System CSC00_2854 ENOG41082GB PTS system galactitol-specific transporter subunit IIA CSC00_2855 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of CSC00_2856 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CSC00_2857 ENOG4105DM4 PTS System CSC00_2858 ENOG4105DE4 1-phosphofructokinase CSC00_2859 ENOG4105D2N Aldolase CSC00_2861 ENOG4105E98 transcriptional regulator DeoR family CSC00_2862 ENOG4107UEK pfkb domain protein CSC00_2863 ENOG4105CTX dehydratase CSC00_2865 ENOG4105DJB Major Facilitator Superfamily CSC00_2866 ENOG4105CNV Aldolase CSC00_2867 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CSC00_2868 ENOG4105BZW Glycerate kinase CSC00_2872 ENOG4106D80 Uncharacterized protein YhaL CSC00_2873 ENOG4108CNN domain protein CSC00_2874 ENOG4105CWB LysR family transcriptional Regulator CSC00_2875 ENOG4105KAF membrAne CSC00_2876 ENOG4105CHF Glutathione S-transferase CSC00_2877 ENOG4108VBZ doxx family CSC00_2878 ENOG4105YJD CSC00_2879 ENOG41090KG Inner membrane protein YqjE CSC00_2880 ENOG4105NE1 Conserved Protein CSC00_2881 ENOG4105WAY exported protein CSC00_2882 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) CSC00_2883 ENOG4106W5V Membrane CSC00_2884 ENOG4107YCY Transcriptional regulator CSC00_2885 ENOG4105DPW Major facilitator superfamily MFS_1 CSC00_2887 ENOG4105CTX dehydratase CSC00_2888 ENOG4105P66 Membrane CSC00_2889 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) CSC00_2890 ENOG4105DU1 integral membrane protein, terc CSC00_2891 ENOG4105EE0 oxidoreductase CSC00_2892 ENOG4108VKG metal-dependent hydrolase CSC00_2895 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) CSC00_2896 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CSC00_2897 ENOG4107RYS Autoinducer-2 (AI-2) kinase CSC00_2898 ENOG4105DKT Transcriptional regulator CSC00_2899 ENOG4105C2J ABC transporter CSC00_2900 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane CSC00_2901 ENOG4105F5R ABC transporter CSC00_2902 ENOG4105D4B ABC, transporter CSC00_2903 ENOG41061GT Aldolase CSC00_2904 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound CSC00_2905 ENOG4105C8Y Acetylornithine aminotransferase CSC00_2906 ENOG4105NTW Transcriptional regulator CSC00_2908 ENOG4105Q26 Siderophore-interacting protein CSC00_2911 ENOG4108UTZ Dihydroxyacetone kinase CSC00_2912 ENOG4105CMT Dihydroxyacetone kinase CSC00_2918 ENOG4105C0A alcohol dehydrogenase CSC00_2921 ENOG4105YCI dehydratase medium subunit CSC00_2922 ENOG4108ZFT Dehydratase small subunit CSC00_2923 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit CSC00_2924 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CSC00_2925 ENOG4105XXV Acid-resistance protein CSC00_2926 ENOG4108YK4 Acid-resistance membrane protein CSC00_2927 ENOG4108V08 YfdX protein CSC00_2928 ENOG4105BZU Histidine kinase CSC00_2929 ENOG4108WQH regulatoR CSC00_2933 ENOG4108VCA G U mismatch-specific DNA glycosylase CSC00_2934 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSC00_2935 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CSC00_2936 ENOG4105VCC 30S ribosomal protein S21 CSC00_2937 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CSC00_2941 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) CSC00_2945 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CSC00_2948 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CSC00_2949 ENOG4107ZVW dihydroneopterin aldolase CSC00_2950 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CSC00_2951 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CSC00_2952 ENOG4106MWK domain protein CSC00_2953 ENOG4105I7R Adenylate cyclase CSC00_2954 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) CSC00_2955 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) CSC00_2958 ENOG4105W0Z cytoplasmic protein CSC00_2959 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CSC00_2961 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CSC00_2962 ENOG4106032 Glutathionylspermidine synthase CSC00_2963 ENOG4105F1G UPF0441 protein CSC00_2965 ENOG41087AY ADP-Ribose pyrophosphatase CSC00_2966 ENOG4108SX3 cytoplasmic protein CSC00_2967 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) CSC00_2968 ENOG4105IPS esterase CSC00_2969 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CSC00_2970 ENOG4105VRH Antibiotic biosynthesis monooxygenase CSC00_2971 ENOG4105NF4 modulator of drug activity CSC00_2972 ENOG4105DHQ Histidine kinase CSC00_2973 ENOG4105XJC Two component transcriptional regulator (Winged helix family CSC00_2974 ENOG4105H4F exported protein CSC00_2975 ENOG4105F4I Transcriptional regulator CSC00_2976 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CSC00_2977 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase CSC00_2978 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) CSC00_2979 ENOG4105CCT upf0313 protein CSC00_2981 ENOG4105CV8 reductase CSC00_2982 ENOG4108I6A alcohol dehydrogenase CSC00_2983 ENOG4105CF7 AraC family transcriptional regulator CSC00_2984 ENOG4108K81 inner membrane protein YghB CSC00_2985 ENOG4105C28 cystathionine CSC00_2987 ENOG4105CWK Biopolymer transport protein, ExbB CSC00_2988 ENOG4108ZZF transport protein (ExbD) CSC00_2989 ENOG4105CT4 transporter CSC00_2990 ENOG4105E4I Glycoside hydrolase family 28 CSC00_2991 ENOG4108TEB UPF0114 protein CSC00_2993 ENOG410900S Protein of unknown function (DUF2623) CSC00_2994 ENOG4105CYM Glutathione S-transferase CSC00_2997 ENOG4106032 Glutathionylspermidine synthase CSC00_2998 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CSC00_3002 ENOG4105CC0 LysR family Transcriptional regulator CSC00_3003 ENOG4105C28 cystathionine CSC00_3011 ENOG4105CDU Replicative dna helicase CSC00_3059 ENOG4105HVQ Regulatory factor of maltose metabolism CSC00_3061 ENOG4105VEQ Cold shock protein CSC00_3062 ENOG4105HVQ Regulatory factor of maltose metabolism CSC00_3070 ENOG4105MFG Antirestriction protein CSC00_3077 ENOG4108UQV Membrane CSC00_3078 ENOG4105CXN decarboxylase CSC00_3079 ENOG4105EAA nucleoside CSC00_3080 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division CSC00_3081 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) CSC00_3082 ENOG4105CEN a g-specific adenine glycosylase CSC00_3083 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CSC00_3084 ENOG41090ED Protein with unknown function (DUF469) CSC00_3085 ENOG4105K33 Periplasmic Protein CSC00_3086 ENOG4105CSA Coproporphyrinogen iii oxidase CSC00_3087 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CSC00_3088 ENOG4105VZ9 UPF0235 protein CSC00_3089 ENOG4108VIA integral membrane protein CSC00_3090 ENOG4105DFA alanine racemase domain protein CSC00_3091 ENOG4105CZX twitching motility protein CSC00_3093 ENOG41086KC Transcriptional regulator CSC00_3094 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CSC00_3095 ENOG4108UJU UPF0301 protein CSC00_3096 ENOG4105D7Z glutathione synthase CSC00_3097 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CSC00_3098 ENOG4105RWS endonuclease I CSC00_3099 ENOG4105GPY SprT protein CSC00_3100 ENOG4107QNK )-transporter CSC00_3101 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CSC00_3110 ENOG4105CHR reductase CSC00_3111 ENOG4108FUF Transcriptional regulator, IclR family CSC00_3113 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase CSC00_3117 ENOG4105CHR reductase CSC00_3118 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) CSC00_3121 ENOG4105J5J Outer membrane porin CSC00_3122 ENOG4108K0D peptidase, M48 CSC00_3123 ENOG4105CV1 Transketolase (EC 2.2.1.1) CSC00_3124 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CSC00_3126 ENOG4105D2N Aldolase CSC00_3127 ENOG4105D64 Mechanosensitive ion channel CSC00_3128 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CSC00_3129 ENOG4105MPN Membrane CSC00_3130 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CSC00_3131 ENOG4105E66 phosphoriboisomerase A CSC00_3133 ENOG4108JQ1 Dehydrogenase CSC00_3134 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CSC00_3135 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) CSC00_3136 ENOG4105E07 UPF0149 protein CSC00_3137 ENOG4107RAQ aminopeptidase CSC00_3138 ENOG4105D0A hydroxylase CSC00_3139 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CSC00_3140 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CSC00_3141 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CSC00_3142 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CSC00_3143 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CSC00_3144 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CSC00_3149 ENOG4105CS2 ec 3.2.1.21 CSC00_3150 ENOG4108Q3X Transcriptional regulator CSC00_3151 ENOG4105N5Z UPF0267 protein CSC00_3152 ENOG4108UT2 hemolysin iii CSC00_3154 ENOG4105Y75 tpr repeat protein CSC00_3155 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB CSC00_3156 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) CSC00_3157 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CSC00_3158 ENOG4105T95 Thiol disulfide interChange protein CSC00_3159 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CSC00_3161 ENOG4105CRK lysyL-tRNA synthetase CSC00_3162 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) CSC00_3164 ENOG4108K5P (LipO)protein CSC00_3166 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSC00_3169 ENOG4105CPC Aldo Keto reductase CSC00_3172 ENOG4105W7K Transcriptional regulator CSC00_3176 ENOG4107R5R arsenical pump membrane protein CSC00_3177 ENOG4105K89 arsenate reductase CSC00_3178 ENOG4105DUX Transporter CSC00_3179 ENOG4105V2F Uncharacterized protein yoac CSC00_3180 ENOG4105ETP RND efflux system, outer membrane lipoprotein CSC00_3181 ENOG4108MI0 Resistance protein CSC00_3182 ENOG4105J12 Multidrug resistance protein mdtN CSC00_3184 ENOG4105VR1 Pfam:DUF1271 CSC00_3185 ENOG410830R acetyltransferase CSC00_3187 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin CSC00_3188 ENOG4108T65 Fimbrial CSC00_3189 ENOG4108SQA Fimbrial CSC00_3190 ENOG4105CW0 outer membrane usher protein CSC00_3191 ENOG4108NAE Fimbrial chaperone protein CSC00_3192 ENOG4108S54 Fimbrial protein CSC00_3193 ENOG4108RQP Major type 1 subunit fimbrin CSC00_3195 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off CSC00_3196 ENOG4105F2I Transposase CSC00_3197 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off CSC00_3199 ENOG4108W9T type 1 fimbriae regulatory protein CSC00_3201 ENOG4105D7X high-affinity nickel-transporter CSC00_3202 ENOG4108ZT1 Transcriptional regulator CSC00_3203 ENOG4108KTG Membrane protein, drug metabolite transporter CSC00_3205 ENOG4105F2I Transposase CSC00_3207 ENOG4108T1W Fimbrial subunit type 3 CSC00_3215 ENOG4107S5I aldo keto reductase CSC00_3216 ENOG4108MHD transport protein CSC00_3218 ENOG4105C5Q Transcriptional regulator CSC00_3219 ENOG4105CHU acetyl-coa acetyltransferase CSC00_3220 ENOG4108QGT oligogalacturonate-specific porin CSC00_3221 ENOG4105CAZ oligogalacturonide lyase CSC00_3223 ENOG4105CHR reductase CSC00_3224 ENOG4107QNK )-transporter CSC00_3225 ENOG4106NDP Transcriptional regulator CSC00_3227 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) CSC00_3228 ENOG4108HKT sucrose-6-phosphate hydrolase CSC00_3231 ENOG4108IJ9 (ABC) transporter CSC00_3232 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CSC00_3233 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CSC00_3234 ENOG4105YKW CSC00_3236 ENOG4105RQF LysR family Transcriptional regulator CSC00_3237 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CSC00_3238 ENOG4105DDV Transcriptional regulator (LacI family CSC00_3239 ENOG4105CK1 PTS System CSC00_3240 ENOG4105CS2 ec 3.2.1.21 CSC00_3241 ENOG4107YCY Transcriptional regulator CSC00_3243 ENOG41060NJ transcriptional regulator CSC00_3245 ENOG4105CEY Amp-dependent synthetase and ligase CSC00_3246 ENOG4107S74 Lysophospholipid transporter LplT CSC00_3247 ENOG4105CPC Aldo Keto reductase CSC00_3249 ENOG4105SUV lipoprotein YgdR CSC00_3250 ENOG4105EE5 Membrane protein terC CSC00_3251 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) CSC00_3253 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CSC00_3254 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase CSC00_3255 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CSC00_3256 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CSC00_3257 ENOG4105IPU prepilin peptidase dependent protein A CSC00_3258 ENOG4105JCS prepilin peptidase dependent protein CSC00_3259 ENOG4105SEN Protein of unknown function (DUF2509) CSC00_3260 ENOG4105RVB Prepilin peptidase dependent protein c CSC00_3261 ENOG4105DSY exodeoxyribonuclease V, gamma CSC00_3262 ENOG4107QXK peptidase CSC00_3263 ENOG4107QKA exodeoxyribonuclease V beta CSC00_3264 ENOG4107QYX exodeoxyribonuclease v alpha CSC00_3266 ENOG4107QZM n-acetylglutamate synthase CSC00_3267 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CSC00_3268 ENOG4107QZB decarboxylase CSC00_3269 ENOG4105JZC GHMP kinase CSC00_3270 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CSC00_3271 ENOG4105KTW ethanolamine utilization protein CSC00_3272 ENOG4105M3W utilization protein CSC00_3274 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) CSC00_3275 ENOG4108EKI Dehydrogenase CSC00_3276 ENOG4108EKI Dehydrogenase CSC00_3278 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml CSC00_3281 ENOG4105KNY Microcompartments protein CSC00_3282 ENOG4105KNY Microcompartments protein CSC00_3284 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit CSC00_3285 ENOG4108ZFT Dehydratase small subunit CSC00_3286 ENOG4105YCI dehydratase medium subunit CSC00_3287 ENOG4105DMB glycerol dehydratase CSC00_3288 ENOG4105EHR propanediol utilization protein pduB CSC00_3289 ENOG4105KNY Microcompartments protein CSC00_3291 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CSC00_3292 ENOG4107XVH Transcriptional regulator CSC00_3293 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CSC00_3294 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CSC00_3295 ENOG41081F0 Precorrin-8x methylmutase CSC00_3296 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) CSC00_3297 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase CSC00_3298 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase CSC00_3299 ENOG4105CIA precorrin-4 C(11)-methyltransferase CSC00_3300 ENOG4108P62 biosynthesis protein (CbiG) CSC00_3301 ENOG4105E4R Precorrin-3B C17-methyltransferase CSC00_3302 ENOG4105QUC reductase CSC00_3303 ENOG4107PPM cobalt chelatase CSC00_3304 ENOG4105DVK Precorrin-2 c20-methyltransferase CSC00_3305 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CSC00_3306 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CSC00_3307 ENOG4108V4M Cobalt abc transporter CSC00_3309 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CSC00_3310 ENOG4108YZT Adenosylcobinamide kinase CSC00_3315 ENOG4105CA3 membrane-bound lytic murein transglycosylase CSC00_3316 ENOG4105CUZ uba thif-type nad fad binding protein CSC00_3317 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) CSC00_3318 ENOG4105C9B Cysteine desulfurase CSC00_3319 ENOG4105M5B (LipO)protein CSC00_3320 ENOG4105ETT transcriptional Regulator, LysR family CSC00_3321 ENOG4105M08 Membrane CSC00_3323 ENOG4107EDW L-fucose operon activator CSC00_3324 ENOG4105NWF RbsD or FucU transport CSC00_3325 ENOG4105CMG Carbohydrate kinase CSC00_3326 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) CSC00_3327 ENOG4105EDR glucose galactose transporter CSC00_3329 ENOG4107W7X Aldolase CSC00_3330 ENOG4105C0A alcohol dehydrogenase CSC00_3332 ENOG4108JU7 Transcriptional regulator CSC00_3334 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CSC00_3337 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CSC00_3338 ENOG4108UMI ABC transporter, permease CSC00_3339 ENOG4105D01 (LipO)protein CSC00_3340 ENOG41079KZ Major Facilitator Superfamily CSC00_3342 ENOG4105GVF (ABC) transporter CSC00_3343 ENOG4105EJQ L-serine dehydratase CSC00_3344 ENOG4105C44 Serine transporter CSC00_3345 ENOG4105EWT decarboxylase family CSC00_3346 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CSC00_3347 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) CSC00_3348 ENOG4105WP7 tRNA pseudouridine synthase C CSC00_3349 ENOG4105DR9 pseudouridine synthase CSC00_3350 ENOG4105QDK Flavodoxin CSC00_3351 ENOG4105DJB Major Facilitator Superfamily CSC00_3352 ENOG4105EQX glucarate dehydratase CSC00_3353 ENOG4105EQX glucarate dehydratase CSC00_3354 ENOG4105BZW Glycerate kinase CSC00_3355 ENOG4105BZU Histidine kinase CSC00_3356 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CSC00_3357 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CSC00_3358 ENOG4105DXN mazG family CSC00_3359 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CSC00_3360 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CSC00_3363 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CSC00_3364 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CSC00_3366 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CSC00_3367 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CSC00_3368 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CSC00_3369 ENOG4108MXK alkaline phosphatase isozyme conversion CSC00_3370 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CSC00_3374 ENOG4105N0Z inner membrane protein ygbE CSC00_3376 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CSC00_3377 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CSC00_3378 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) CSC00_3380 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CSC00_3381 ENOG4108K5P (LipO)protein CSC00_3382 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSC00_3387 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CSC00_3388 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CSC00_3389 ENOG4105KZM cytoplasmic protein CSC00_3390 ENOG4107635 Hok Gef family protein CSC00_3391 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CSC00_3394 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CSC00_3395 ENOG4105EHG Permease protein CSC00_3396 ENOG4107R4I Periplasmic binding protein CSC00_3397 ENOG4106QJH hemin transport protein CSC00_3401 ENOG4108N2Y auxin Efflux CSC00_3403 ENOG4105VXR cytoplasmic protein CSC00_3404 ENOG4105CC5 ABC transporter CSC00_3405 ENOG4105CC5 ABC transporter CSC00_3406 ENOG4105DIK (ABC) transporter CSC00_3407 ENOG4105DSE periplasmic solute binding protein CSC00_3408 ENOG4105DDV Transcriptional regulator (LacI family CSC00_3409 ENOG4105DKQ ROK family CSC00_3410 ENOG4105VCP PTS System CSC00_3411 ENOG4105CK1 PTS System CSC00_3412 ENOG4105VZJ PTS System CSC00_3413 ENOG4105CK1 PTS System CSC00_3414 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) CSC00_3416 ENOG4105CS2 ec 3.2.1.21 CSC00_3418 ENOG4105C45 hydrogenase expression formation protein (HypE) CSC00_3419 ENOG4105CQS hydrogenase expression formation protein HypD CSC00_3420 ENOG41083WG hydrogenase assembly chaperone CSC00_3421 ENOG4107RSS Hydrogenase accessory protein HypB CSC00_3423 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CSC00_3424 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA CSC00_3425 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) CSC00_3426 ENOG4107R30 NADH dehydrogenase CSC00_3427 ENOG4107TDF Formate hydrogenlyase subunit 4 CSC00_3428 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CSC00_3429 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit CSC00_3430 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit CSC00_3431 ENOG4105I6X formate hydrogenlyase maturation CSC00_3432 ENOG4108MG9 hydrogenase 3 maturation protease CSC00_3435 ENOG4105CS2 ec 3.2.1.21 CSC00_3436 ENOG4105C5Y PTS System CSC00_3439 ENOG4105DDV Transcriptional regulator (LacI family CSC00_3440 ENOG4108RC0 Electron transport protein CSC00_3441 ENOG4105C8H hydrogenase maturation protein Hypf CSC00_3443 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase CSC00_3444 ENOG4105CNW domain protein CSC00_3446 ENOG4108JUA Transcriptional regulator CSC00_3448 ENOG410804X Transcriptional regulator CSC00_3449 ENOG4105J92 DNA-binding transcriptional activator GutM CSC00_3450 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase CSC00_3451 ENOG4105VI0 Pts system, glucitol sorbitol-specific CSC00_3452 ENOG4105DZY Pts system, glucitol sorbitol-specific CSC00_3453 ENOG410787A Pts system, glucitol sorbitol-specific CSC00_3454 ENOG4105CVE Lytic murein transglycosylase CSC00_3456 ENOG4105CC5 ABC transporter CSC00_3457 ENOG4105DSE periplasmic solute binding protein CSC00_3458 ENOG4107TH8 cina domain protein CSC00_3459 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CSC00_3460 ENOG4105Y3E Modulates RecA activity (By similarity) CSC00_3462 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CSC00_3463 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) CSC00_3470 ENOG4105K3G Periplasmic Protein CSC00_3471 ENOG4107VXZ Hydrolase CSC00_3472 ENOG4105W39 Membrane CSC00_3473 ENOG4105D9M gamma-glutamylcysteine synthetase CSC00_3476 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CSC00_3477 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSC00_3478 ENOG4105CW7 secretion protein, HlyD family CSC00_3480 ENOG4105NTK Transcriptional repressor Mpra CSC00_3481 ENOG4105ZED uncharacterized protein ygaH CSC00_3482 ENOG4108UMN azlc family CSC00_3483 ENOG4105GIJ Glycine betaine CSC00_3484 ENOG4108HQS Glycine betaine CSC00_3485 ENOG4108IJ7 Glycine betaine CSC00_3486 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CSC00_3487 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CSC00_3488 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CSC00_3489 ENOG4105WAZ (Glutaredoxin-like protein) NrdH CSC00_3490 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CSC00_3491 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CSC00_3492 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) CSC00_3493 ENOG4108WMJ Protein of unknown function (DUF2002) CSC00_3496 ENOG4108X73 DNA- binding protein CSC00_3499 ENOG4108V62 Rhodanese domain protein CSC00_3500 ENOG41080HT Transcriptional regulator, arsr family CSC00_3502 ENOG4105CC0 LysR family Transcriptional regulator CSC00_3503 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CSC00_3504 ENOG4105C26 Dehydrogenase CSC00_3507 ENOG4105X0I Fimbrial CSC00_3508 ENOG4108VCD Chaperone CSC00_3509 ENOG4105CW0 outer membrane usher protein CSC00_3512 ENOG4105CW0 outer membrane usher protein CSC00_3513 ENOG4106P2F Pfam:Pili_assembly_C CSC00_3514 ENOG4106EAR Fimbrial protein CSC00_3515 ENOG4108WQH regulatoR CSC00_3518 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CSC00_3519 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase CSC00_3520 ENOG4105MP9 class II Aldolase CSC00_3522 ENOG4106TNF Periplasmic binding protein CSC00_3525 ENOG4105CYW agmatinase CSC00_3526 ENOG4105EVZ LysR family transcriptional regulator CSC00_3530 ENOG4105C1P efflux transporter, rnd family, mfp subunit CSC00_3531 ENOG4105UEI Transcriptional Regulator AraC Family CSC00_3537 ENOG4108Z1B Cyclase dehydrase CSC00_3539 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CSC00_3541 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CSC00_3543 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CSC00_3544 ENOG4108JU6 CBS domain protein CSC00_3545 ENOG4106KVJ cytochrome C assembly protein CSC00_3546 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY CSC00_3547 ENOG4105K5M 30s ribosomal protein S16 CSC00_3548 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CSC00_3549 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CSC00_3550 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CSC00_3554 ENOG41090EK ompa motb domain protein CSC00_3555 ENOG4108KHX Diguanylate cyclase CSC00_3556 ENOG4108WS1 CSC00_3557 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CSC00_3558 ENOG4105EHE chorismate mutase- prephenate dehydrogenase CSC00_3560 ENOG4105CQC Prephenate dehydratase CSC00_3561 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA CSC00_3562 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CSC00_3563 ENOG4105C34 Pseudouridine synthase CSC00_3564 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CSC00_3566 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CSC00_3573 ENOG4105CSH Transporter CSC00_3574 ENOG4105T42 (LipO)protein CSC00_3575 ENOG4105JIM Phosphatidylserine synthase CSC00_3576 ENOG4105CD5 CoA-binding domain protein CSC00_3577 ENOG4106IUH DTW domain containing protein CSC00_3578 ENOG4105K63 Thioredoxin CSC00_3579 ENOG4105EIB trna rrna methyltransferase CSC00_3580 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CSC00_3582 ENOG4105C1J atp-dependent rna helicase CSC00_3583 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) CSC00_3584 ENOG4108IYU L-aspartate oxidase CSC00_3586 ENOG41069PW sigma-e factor negative regulatory protein CSC00_3587 ENOG4105VQK sigma E regulatory protein, MucB RseB CSC00_3588 ENOG4105WMJ Positive regulator of sigma E, RseC MucC CSC00_3589 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CSC00_3590 ENOG4105C3F Signal peptidase i CSC00_3592 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CSC00_3593 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) CSC00_3594 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) CSC00_3595 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CSC00_3596 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding CSC00_3597 ENOG4106G6Q Transcriptional regulator CSC00_3598 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB CSC00_3599 ENOG4108Z6B deaminase CSC00_3600 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) CSC00_3601 ENOG4108ETH Formylglycinamide ribotide synthetase CSC00_3602 ENOG4107WP9 Histidine kinase CSC00_3603 ENOG4108SKK alpha helix protein CSC00_3604 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CSC00_3605 ENOG4108YZA Nitrogen regulatory protein pii CSC00_3606 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CSC00_3607 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CSC00_3608 ENOG4108SB3 DoxX Family CSC00_3609 ENOG4108NZE NAGC-like transcriptional regulator CSC00_3610 ENOG4107HQ7 repeat protein CSC00_3611 ENOG4107QNK )-transporter CSC00_3612 ENOG4108ZKT aldose 1-epimerase CSC00_3613 ENOG4105D8G Major Facilitator superfamily CSC00_3614 ENOG4108MN2 Stationary phase inducible protein CsiE CSC00_3615 ENOG41065CD Exported protein CSC00_3616 ENOG4105D7X high-affinity nickel-transporter CSC00_3618 ENOG4105ECY inositol monophosphatase CSC00_3619 ENOG4105CVS RNA methyltransferase TrmH family, group 1 CSC00_3621 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family CSC00_3622 ENOG4105C3J Cysteine desulfurase CSC00_3623 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins CSC00_3624 ENOG4108Z4V iron-sulfur cluster assembly CSC00_3625 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) CSC00_3626 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB CSC00_3627 ENOG4108ZIT Ferredoxin, 2FE-2S CSC00_3628 ENOG4105WVQ Fe-S assembly protein IscX CSC00_3629 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CSC00_3630 ENOG4105YYA enhanced serine sensitivity protein SseB CSC00_3632 ENOG4105KHC sulfurtransferase CSC00_3633 ENOG4105DN3 alpha-2-macroglobulin domain protein CSC00_3634 ENOG4108JQB penicillin-binding protein 1C CSC00_3636 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CSC00_3638 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) CSC00_3639 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CSC00_3641 ENOG4105N21 Membrane CSC00_3642 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CSC00_3643 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CSC00_3645 ENOG4105VPD cellular component movement CSC00_3646 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CSC00_3648 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CSC00_3649 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CSC00_3651 ENOG4105C4X radical SAM domain protein CSC00_3654 ENOG41062G3 Protein of unknown function (DUF2633) CSC00_3655 ENOG4105BZU Histidine kinase CSC00_3656 ENOG4105C9X ppx gppa phosphatase CSC00_3657 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CSC00_3658 ENOG4108V3E phosphoribosylglycinamide formyltransferase CSC00_3659 ENOG4105CXB phosphoribosylaminoimidazole synthetase CSC00_3660 ENOG41066F8 ROK family CSC00_3661 ENOG4105CS2 ec 3.2.1.21 CSC00_3662 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CSC00_3663 ENOG4105C2W permease CSC00_3666 ENOG4105K89 arsenate reductase CSC00_3667 ENOG4105ERG peptidase m48, ste24p CSC00_3669 ENOG4105C02 permease CSC00_3670 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CSC00_3671 ENOG4105RH4 Glycine cleavage system transcriptional repressor CSC00_3672 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CSC00_3673 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CSC00_3675 ENOG4105CGZ zinc metallopeptidase CSC00_3676 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) CSC00_3677 ENOG4106KED esterase YpfH CSC00_3678 ENOG4105XYK UPF0370 protein CSC00_3679 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CSC00_3680 ENOG4105KUZ arsenate reductase CSC00_3681 ENOG4105BZS acriflavin resistance protein CSC00_3682 ENOG4105BZ8 glutamate synthase CSC00_3683 ENOG4107VIJ nudix hydrolase CSC00_3684 ENOG4108PVD exported protein CSC00_3685 ENOG4105CV1 Transketolase (EC 2.2.1.1) CSC00_3686 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CSC00_3687 ENOG4105C6K Malic enzyme CSC00_3688 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place CSC00_3689 ENOG4106S4J ethanolamine utilization protein EutP CSC00_3690 ENOG4105NDK ethanolamine utilization protein CSC00_3691 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase CSC00_3692 ENOG4108IJ2 phosphate acetyltransferase CSC00_3693 ENOG4105KNY Microcompartments protein CSC00_3694 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml CSC00_3695 ENOG4108EKI Dehydrogenase CSC00_3696 ENOG4107RWI ethanolamine utilization protein eutJ CSC00_3697 ENOG4105C0A alcohol dehydrogenase CSC00_3698 ENOG4105ENY Ethanolamine utilization protein eutH CSC00_3699 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase CSC00_3700 ENOG4105CPD ethanolamine ammonia-lyase CSC00_3702 ENOG4106D67 ethanolamine utilization protein CSC00_3703 ENOG4108X49 Ethanolamine utilization protein EutK CSC00_3704 ENOG4108K3Z AraC family transcriptional regulator CSC00_3705 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) CSC00_3706 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase CSC00_3708 ENOG4105QZU Inner membrane protein YfeZ CSC00_3709 ENOG4105E7K (LipO)protein CSC00_3710 ENOG4105EZR dyp-type peroxidase family protein CSC00_3711 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein CSC00_3712 ENOG4108I5D sulfate abc transporter CSC00_3713 ENOG4105ECW sulfate abc transporter CSC00_3714 ENOG4108IJ6 ABC transporter CSC00_3715 ENOG4105C6T cysteine synthase CSC00_3716 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein CSC00_3717 ENOG4105CSW GntR family transcriptional regulator CSC00_3720 ENOG4105C5Y PTS System CSC00_3722 ENOG4105KZ7 phosphocarrier protein hpr CSC00_3723 ENOG4105C6T cysteine synthase CSC00_3724 ENOG4105EXN Sulfate transport protein CysZ CSC00_3726 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) CSC00_3727 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CSC00_3728 ENOG4105VRT cytoplasmic protein CSC00_3729 ENOG4105DHU Bile acid CSC00_3730 ENOG4108M0I Transcriptional regulator CSC00_3736 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CSC00_3737 ENOG4105GXM Putative transcription regulator (DUF1323) CSC00_3738 ENOG4105HZG regulatoR CSC00_3741 ENOG4108KMM Diguanylate cyclase CSC00_3742 ENOG4105D9N nucleoside CSC00_3743 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CSC00_3744 ENOG4109076 Conserved Protein CSC00_3745 ENOG4105CPC Aldo Keto reductase CSC00_3746 ENOG4107RA9 decarboxylase CSC00_3748 ENOG4105CHC glucokinase (EC 2.7.1.2) CSC00_3749 ENOG4105DY9 regulatoR CSC00_3750 ENOG4108HRK Histidine kinase CSC00_3752 ENOG4105CHM Aminotransferase CSC00_3753 ENOG4105DJ2 Major Facilitator Superfamily CSC00_3754 ENOG4107Y2X deaminase CSC00_3755 ENOG4105DND Transcriptional regulator CSC00_3760 ENOG4105S64 Formate nitrite transporter CSC00_3761 ENOG410903C (LipO)protein CSC00_3762 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation CSC00_3763 ENOG4105KZW UPF0381 protein CSC00_3764 ENOG4105CHU acetyl-coa acetyltransferase CSC00_3765 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CSC00_3766 ENOG4108BY2 phosphohistidine phosphatase CSC00_3767 ENOG4108DG9 Smr protein MutS2 CSC00_3768 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) CSC00_3769 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CSC00_3770 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) CSC00_3771 ENOG4105EJ9 Membrane CSC00_3772 ENOG4108BPE -transporting atpase CSC00_3773 ENOG4105MH2 YfcL protein CSC00_3774 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) CSC00_3775 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CSC00_3776 ENOG4105F9N Major Facilitator Superfamily CSC00_3777 ENOG4106WZ1 flagella biosynthesis regulator CSC00_3780 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CSC00_3781 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CSC00_3782 ENOG4105DQR SNARE associated Golgi CSC00_3783 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CSC00_3784 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CSC00_3785 ENOG4108S3P Sporulation domain protein CSC00_3786 ENOG4105E96 Colicin v production protein CSC00_3787 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CSC00_3788 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CSC00_3790 ENOG4105E89 ABC transporter CSC00_3791 ENOG4105E89 ABC transporter CSC00_3792 ENOG4105DSP amino acid AbC transporter CSC00_3793 ENOG4106YG3 ABC transporter CSC00_3794 ENOG4108JEH abc transporter atp-binding protein CSC00_3795 ENOG4105KNA -acetyltransferase CSC00_3797 ENOG4105ECP epimerase CSC00_3798 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase CSC00_3799 ENOG4105CYM Glutathione S-transferase CSC00_3800 ENOG4108SHQ Glutathione S-transferase CSC00_3801 ENOG4108RE9 Phosphodiesterase CSC00_3802 ENOG4105PTV Nudix Hydrolase CSC00_3803 ENOG4105C6K Malic enzyme CSC00_3804 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CSC00_3809 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 CSC00_3810 ENOG4107QWE )-transporter CSC00_3812 ENOG4105CHM Aminotransferase CSC00_3814 ENOG4107NQ8 LysR family Transcriptional regulator CSC00_3816 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CSC00_3818 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CSC00_3819 ENOG4105GKE subunit e CSC00_3820 ENOG4107QIZ NADH dehydrogenase CSC00_3821 ENOG4107R0R NADH dehydrogenase subunit g CSC00_3824 ENOG4107UFS subunit j CSC00_3826 ENOG4105D65 subunit l CSC00_3827 ENOG4105C8S subunit m CSC00_3828 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CSC00_3829 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CSC00_3830 ENOG4107YB6 acetyltransferase, (GNAT) family CSC00_3831 ENOG4105E4F Isochorismate synthase CSC00_3832 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CSC00_3833 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CSC00_3834 ENOG4108IPT Naphthoate synthase CSC00_3835 ENOG4105DNI Converts SHCHC to OSB (By similarity) CSC00_3836 ENOG4105CEY Amp-dependent synthetase and ligase CSC00_3839 ENOG4105DNE Transposase CSC00_3841 ENOG4108UII YfaZ family CSC00_3843 ENOG4107258 Transcriptional regulator CSC00_3844 ENOG4105CXK mandelate racemase muconate lactonizing CSC00_3846 ENOG4105CSP Major Facilitator Superfamily CSC00_3847 ENOG4105CNV Aldolase CSC00_3848 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CSC00_3849 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B CSC00_3850 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A CSC00_3851 ENOG4105CXY transporter CSC00_3852 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase CSC00_3853 ENOG4105XPH Ferredoxin CSC00_3854 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CSC00_3855 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CSC00_3856 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CSC00_3857 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CSC00_3858 ENOG4105BZU Histidine kinase CSC00_3859 ENOG41068CG regulatoR CSC00_3860 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC CSC00_3864 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CSC00_3865 ENOG4105CF1 Alkylated DNA repair protein CSC00_3866 ENOG4105IBP Cyclic peptide transporter CSC00_3867 ENOG4105CJW magnesium transporter CSC00_3868 ENOG4105CHH sulfate transporter CSC00_3871 ENOG4105F4G Membrane CSC00_3873 ENOG4105E68 Sulfatase CSC00_3874 ENOG4105PAN UPF0352 protein CSC00_3875 ENOG4106V8H Nucleoid-associated protein CSC00_3876 ENOG4105N2W Transcriptional regulator CSC00_3877 ENOG4107VIJ nudix hydrolase CSC00_3880 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CSC00_3881 ENOG4105CFI type iii restriction protein res subunit CSC00_3882 ENOG4105I08 Pseudouridine synthase CSC00_3883 ENOG4105C2C drug resistance transporter, Bcr CflA CSC00_3884 ENOG4105HG6 CSC00_3885 ENOG4108JQ5 ABC transporter CSC00_3886 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component CSC00_3887 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component CSC00_3888 ENOG4105E43 Extracellular solute-binding protein, family 5 CSC00_3889 ENOG4105CXC rtn protein CSC00_3890 ENOG4107TT5 NLP P60 protein CSC00_3893 ENOG41076MN Phosphoesterase, PA-phosphatase related CSC00_3894 ENOG4105CKI cobalamin synthesis protein CSC00_3895 ENOG4105DEI Mannitol dehydrogenase CSC00_3896 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CSC00_3898 ENOG4105KRS Proteinase inhibitor CSC00_3899 ENOG4105S8Q sugar efflux transporter CSC00_3900 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CSC00_3901 ENOG4105DE4 1-phosphofructokinase CSC00_3902 ENOG4105DM4 PTS System CSC00_3903 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CSC00_3904 ENOG4105HMI Membrane CSC00_3906 ENOG4105DUM transcriptional regulator, lysR family CSC00_3907 ENOG4108IQI permease CSC00_3909 ENOG4105D05 Receptor CSC00_3911 ENOG4105EUJ GTP cyclohydrolase i CSC00_3912 ENOG4105DHF Membrane CSC00_3913 ENOG41060NJ transcriptional regulator CSC00_3915 ENOG4105C2J ABC transporter CSC00_3916 ENOG4107SDZ Galactoside transport system permease protein mglC CSC00_3917 ENOG4107GZ4 SanA protein CSC00_3918 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) CSC00_3919 ENOG41067MG lrgb family CSC00_3920 ENOG4105VAW lrga family CSC00_3921 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) CSC00_3923 ENOG4105TW1 Carbohydrate-selective porin OprB CSC00_3926 ENOG4105CS2 ec 3.2.1.21 CSC00_3929 ENOG4105KHU inner membrane protein YohD CSC00_3930 ENOG41069YE inner membrane protein yohC CSC00_3931 ENOG41061WM D-Alanyl-D-Alanine CSC00_3933 ENOG4105CXG d-lactate dehydrogenase CSC00_3934 ENOG4107QK4 glycoside hydrolase, family 3 domain protein CSC00_3935 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system CSC00_3936 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component CSC00_3937 ENOG4108IJ8 ABC transporter CSC00_3938 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component CSC00_3940 ENOG4108HRK Histidine kinase CSC00_3941 ENOG4108NEV two component transcriptional regulator, LytTR family CSC00_3942 ENOG4108W15 Protein of unknown function (DUF1456) CSC00_3943 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CSC00_3945 ENOG4105D1F ATP-binding protein CSC00_3947 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly CSC00_3948 ENOG4105EJC lysr family transcriptional regulator CSC00_3949 ENOG4105C7N Xanthine uracil vitamin C permease CSC00_3950 ENOG4105CPN adenine deaminase CSC00_3951 ENOG4105DUM transcriptional regulator, lysR family CSC00_3952 ENOG4105EUZ Beta-lactamase domain protein CSC00_3954 ENOG4105EUZ Beta-lactamase domain protein CSC00_3957 ENOG4105DWF phosphomethylpyrimidine kinase CSC00_3958 ENOG4105EIE fructose-bisphosphate aldolase CSC00_3959 ENOG4105IE8 Alpha-ketoglutarate permease CSC00_3965 ENOG4105DEI Mannitol dehydrogenase CSC00_3966 ENOG4105CMG Carbohydrate kinase CSC00_3967 ENOG4105IE8 Alpha-ketoglutarate permease CSC00_3968 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 CSC00_3970 ENOG4105DQ6 Transposase CSC00_3972 ENOG4105CFP Peptidase U32 CSC00_3973 ENOG4105E3W Two component transcriptional regulator (Winged helix family CSC00_3974 ENOG4105EB3 Histidine kinase CSC00_3975 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSC00_3976 ENOG4105BZS acriflavin resistance protein CSC00_3977 ENOG4105BZS acriflavin resistance protein CSC00_3978 ENOG4105ENT Efflux transporter rnd family, mfp subunit CSC00_3979 ENOG4105CK2 sodium dicarboxylate symporter CSC00_3983 ENOG4105BZU Histidine kinase CSC00_3984 ENOG4105R8A Heat shock protein CSC00_3985 ENOG4105D03 DNA-3-methyladenine glycosylase II CSC00_3988 ENOG4108GAE asmA family CSC00_3989 ENOG4105EE5 Membrane protein terC CSC00_3990 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CSC00_3991 ENOG4105MH5 phosphoesterase PA-phosphatase related protein CSC00_3994 ENOG4108MRJ CSC00_3995 ENOG4105DAY polysaccharide export protein CSC00_3999 ENOG4105D3Q Sugar transferase CSC00_4004 ENOG4105C0K Gdp-mannose 4,6-dehydratase CSC00_4005 ENOG4105C30 Nad-dependent epimerase dehydratase CSC00_4006 ENOG4105FGF GDP-mannose mannosyl hydrolase CSC00_4007 ENOG4106CD9 glycosyl transferase group 1 CSC00_4009 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CSC00_4021 ENOG4105CPK Glycosyl transferase (Group 1 CSC00_4026 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CSC00_4027 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CSC00_4029 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CSC00_4030 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CSC00_4031 ENOG4105CIH Imidazole acetol-phosphate transaminase CSC00_4034 ENOG4108535 NAD dependent epimerase/dehydratase family CSC00_4035 ENOG4105EQ1 Transcriptional regulator CSC00_4036 ENOG4105CUB amino acid CSC00_4037 ENOG4105YVS arsR family transcriptional regulator CSC00_4038 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CSC00_4039 ENOG4105CJB Exodeoxyribonuclease I CSC00_4040 ENOG4105DZ1 carboxypeptidase CSC00_4041 ENOG4105EKQ RNA-directed DNA polymerase CSC00_4043 ENOG4105DR8 Membrane CSC00_4045 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) CSC00_4047 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) CSC00_4049 ENOG41090U3 tautomerase CSC00_4050 ENOG4105HEI LysR family (Transcriptional regulator CSC00_4051 ENOG4108KMH lipoate-protein ligase a CSC00_4052 ENOG4105CSH Transporter CSC00_4054 ENOG4105BZU Histidine kinase CSC00_4056 ENOG4108YS1 cytoplasmic protein CSC00_4057 ENOG4105YP6 Domain of unknown function (DUF1869) CSC00_4058 ENOG4105ETT transcriptional Regulator, LysR family CSC00_4061 ENOG4105BZU Histidine kinase CSC00_4090 ENOG4105D8D Type III CSC00_4096 ENOG4105UQX Mate efflux family protein CSC00_4098 ENOG4105FYV Amp nucleosidase CSC00_4102 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family CSC00_4103 ENOG4108WUH Transcriptional regulator, TetR family CSC00_4104 ENOG4105EEQ Na H antiporter CSC00_4107 ENOG4107R11 Transcriptional regulator CSC00_4108 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CSC00_4111 ENOG4108UQ8 endoribonuclease L-psp CSC00_4113 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) CSC00_4115 ENOG4105FCK Membrane CSC00_4116 ENOG4105Y0K Inner membrane protein YedR CSC00_4117 ENOG4105EST Metal Dependent Phosphohydrolase CSC00_4118 ENOG4105DVF Cytosine-specific methyltransferase CSC00_4119 ENOG41090BB DNA mismatch endonuclease (vsr) CSC00_4120 ENOG4105FDR Membrane CSC00_4121 ENOG4105CKW Inner membrane protein yedI CSC00_4123 ENOG4105YX3 cellular response to acidity CSC00_4126 ENOG4105JCU Inherit from NOG: (Lipo)protein CSC00_4127 ENOG4105E5K Alpha-amylase CSC00_4128 ENOG4105EAB amino acid AbC transporter CSC00_4129 ENOG4105K6H D-cysteine desulfhydrase CSC00_4130 ENOG4105E5Q amino acid AbC transporter CSC00_4131 ENOG4105CDA abc transporter atp-binding protein CSC00_4132 ENOG4105VJY transcriptional regulator CSC00_4133 ENOG4105XVG cytoplasmic protein CSC00_4134 ENOG4105WH1 Two component transcriptional regulator luxr family CSC00_4136 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CSC00_4141 ENOG4106RHG Yeca family CSC00_4142 ENOG4105E0U tyrosine-specific transport protein CSC00_4143 ENOG4105VVZ metal-binding protein CSC00_4144 ENOG41090A1 ferritin CSC00_4147 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSC00_4148 ENOG4105N4N Protein of unknown function (DUF2766) CSC00_4151 ENOG4108UEC Ferritin-like protein CSC00_4153 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator CSC00_4155 ENOG4105CNN ABC, transporter CSC00_4157 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase CSC00_4158 ENOG4108VA4 Universal stress protein CSC00_4159 ENOG4105CT4 transporter CSC00_4160 ENOG4105F5H Glycosyl Hydrolase Family 88 CSC00_4161 ENOG4105C75 arginyL-tRNA synthetase CSC00_4162 ENOG4106ZCM YecM protein CSC00_4163 ENOG4106N3A copper homeostasis protein cutc CSC00_4164 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) CSC00_4165 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) CSC00_4166 ENOG4105WJG Glutathione CSC00_4167 ENOG41081XQ Conserved Protein CSC00_4168 ENOG4105D3W isochorismatase CSC00_4169 ENOG4105C9M aspartyl-trna synthetase CSC00_4170 ENOG4108TIT dATP pyrophosphohydrolase CSC00_4172 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) CSC00_4174 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CSC00_4175 ENOG4105FAV ABC, transporter CSC00_4177 ENOG4105NXV High-affinity zinc uptake system protein CSC00_4178 ENOG4105DR5 peptidase CSC00_4179 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase CSC00_4180 ENOG4105CA9 Pyruvate kinase CSC00_4181 ENOG4106KNT transcriptional regulator CSC00_4184 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CSC00_4185 ENOG4105C01 Dihydroxy-acid dehydratase CSC00_4186 ENOG4108UHU Aldolase CSC00_4188 ENOG4105X2V dna damage-inducible protein CSC00_4189 ENOG4108Q2J Inner membrane protein YebE CSC00_4190 ENOG4105CUG Oligopeptidase b CSC00_4191 ENOG4105UMD exodeoxyribonuclease X CSC00_4192 ENOG4105MPK DNA polymerase III subunit theta CSC00_4193 ENOG4105FXM Copper resistance protein CSC00_4194 ENOG4108PNC copper resistance CSC00_4195 ENOG4105NKT exported protein CSC00_4197 ENOG4108MJ5 VirK protein CSC00_4198 ENOG4108R1E Serine threonine protein phosphatase 1 CSC00_4199 ENOG4105UVW uncharacterized protein yebW CSC00_4200 ENOG4105WT8 Protein of unknown function (DUF1480) CSC00_4201 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CSC00_4202 ENOG4105DY2 Paraquat-inducible protein b CSC00_4203 ENOG4105H2K paraquat-inducible protein a CSC00_4204 ENOG4108ZGC gaf domain protein CSC00_4205 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) CSC00_4206 ENOG4105CN1 protease CSC00_4207 ENOG4105D0M Protease HtpX homolog CSC00_4208 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSC00_4209 ENOG4105J4Q Transcriptional regulator CSC00_4210 ENOG4105TIK CSC00_4212 ENOG4105Q3Y exported protein CSC00_4214 ENOG4105VEQ Cold shock protein CSC00_4215 ENOG4105CJN penicillin-binding protein CSC00_4216 ENOG4105DHI Methyltransferase CSC00_4217 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) CSC00_4218 ENOG4108NK4 UPF0266 membrane protein CSC00_4219 ENOG4105F3R pts system mannose fructose sorbose family iid CSC00_4220 ENOG4105ETZ PTS System CSC00_4221 ENOG4108EQA pts system CSC00_4222 ENOG4105EE5 Membrane protein terC CSC00_4223 ENOG4107XTP (EAL) domain protein CSC00_4224 ENOG4105EJQ L-serine dehydratase CSC00_4225 ENOG4105P8F nudix hydrolase CSC00_4227 ENOG4105X5C UPF0181 protein CSC00_4228 ENOG4105M4H endoribonuclease L-psp CSC00_4229 ENOG4105DVT helicase CSC00_4230 ENOG41072GX Peptidase M22 Glycoprotease CSC00_4231 ENOG4105Y4Z Outer Membrane Lipoprotein CSC00_4232 ENOG4105CEY Amp-dependent synthetase and ligase CSC00_4233 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) CSC00_4234 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) CSC00_4235 ENOG4107QMS site-determining protein CSC00_4236 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CSC00_4237 ENOG4105VNG YcgL domain-containing protein CSC00_4238 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase CSC00_4239 ENOG4108ZZ3 UPF0260 protein CSC00_4242 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CSC00_4244 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) CSC00_4245 ENOG4105ED1 spovr family CSC00_4247 ENOG4105MWK D-amino acid dehydrogenase, small subunit CSC00_4249 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) CSC00_4250 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CSC00_4251 ENOG4106JQ5 Transglycosylase SLT domain CSC00_4252 ENOG4105E0K tonB-dependent siderophore receptor CSC00_4263 ENOG410811B TRANSCRIPTIONal CSC00_4264 ENOG4105C7B Threonine dehydratase CSC00_4267 ENOG4105C6N Formate acetyltransferase CSC00_4269 ENOG4105C32 Amino acid ABC transporter (Permease) CSC00_4270 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CSC00_4271 ENOG4105C0Z ABC transporter CSC00_4272 ENOG4108IV0 ABC, transporter CSC00_4273 ENOG4107YNJ LysR family Transcriptional regulator CSC00_4277 ENOG4105CSH Transporter CSC00_4279 ENOG4105F04 LysR family Transcriptional regulator CSC00_4281 ENOG4105D3G Pseudouridine synthase CSC00_4282 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme CSC00_4287 ENOG4108ZG0 Ompa motb domain protein CSC00_4289 ENOG4105CS6 Rhs element vgr protein CSC00_4303 ENOG4105E6M Sulphatase-modifying factor protein CSC00_4309 ENOG4105F2I Transposase CSC00_4323 ENOG4105C3G gtp-binding protein CSC00_4326 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria CSC00_4328 ENOG4105CHH sulfate transporter CSC00_4329 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CSC00_4330 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CSC00_4332 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CSC00_4333 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CSC00_4334 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CSC00_4335 ENOG4108YY7 Invasion gene expression up-regulator SirB CSC00_4336 ENOG41063JG Transcriptional regulator CSC00_4338 ENOG4105EWV Sodium calcium exchanger membrane region CSC00_4339 ENOG4105WS7 Cation transport regulator CSC00_4340 ENOG4108NH8 Cation transport protein CSC00_4343 ENOG41090EX DsrE family CSC00_4345 ENOG4105I5W Transporter CSC00_4347 ENOG4105D7T ABC transporter CSC00_4348 ENOG4107QZF nitrite reductase NADPH large subunit CSC00_4350 ENOG4105ID0 Putative invasin CSC00_4351 ENOG4105WH1 Two component transcriptional regulator luxr family CSC00_4352 ENOG4105BZU Histidine kinase CSC00_4353 ENOG4105DQQ Major facilitator superfamily MFS_1 CSC00_4355 ENOG4105CRU nitrate reductase, alpha subunit CSC00_4356 ENOG4108IUE nitrate reductase beta subunit CSC00_4357 ENOG4105R3A Nitrate reductase CSC00_4358 ENOG41076YT nitrate reductase, gamma subunit CSC00_4363 ENOG4105CIY formyltetrahydrofolate deformylase CSC00_4365 ENOG4105D78 K07001 NTE family protein CSC00_4366 ENOG4105I93 response regulator CSC00_4367 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CSC00_4370 ENOG4107104 thymidine kinase CSC00_4371 ENOG4108EKI Dehydrogenase CSC00_4373 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein CSC00_4375 ENOG4108J59 Extracellular solute-binding protein, family 5 CSC00_4377 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSC00_4378 ENOG4105C3U ABC transporter CSC00_4379 ENOG4108JQ7 (ABC) transporter CSC00_4380 ENOG4105EYW Ion transport protein CSC00_4382 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CSC00_4385 ENOG4108YYC ycei family CSC00_4386 ENOG4105K9H YciI-like protein CSC00_4387 ENOG410822N TonB family CSC00_4388 ENOG4105FGM Fructosamine kinase CSC00_4389 ENOG4105P10 Uncharacterized protein ydiZ CSC00_4390 ENOG4105DE4 1-phosphofructokinase CSC00_4391 ENOG4108NE3 Salt-induced outer membrane protein CSC00_4394 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CSC00_4395 ENOG41082NX 50s ribosomal protein l35 CSC00_4396 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CSC00_4397 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CSC00_4398 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CSC00_4401 ENOG4105MWK D-amino acid dehydrogenase, small subunit CSC00_4402 ENOG4105RQF LysR family Transcriptional regulator CSC00_4404 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) CSC00_4405 ENOG4105D01 (LipO)protein CSC00_4406 ENOG4108V06 Glutathione peroxidase CSC00_4408 ENOG4108QBX (LipO)protein CSC00_4409 ENOG4105CNG UPF0061 protein CSC00_4410 ENOG4106EDX Hemin uptake protein CSC00_4411 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CSC00_4414 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CSC00_4415 ENOG4105IPI Membrane CSC00_4417 ENOG4105CQB FAD linked oxidase domain protein CSC00_4418 ENOG4105KA0 thioesterase Superfamily protein CSC00_4419 ENOG4105Y3U Transglycosylase-associated protein CSC00_4423 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CSC00_4425 ENOG4105E0A ABC, transporter CSC00_4426 ENOG4105EHG Permease protein CSC00_4428 ENOG4106KR7 LysR family Transcriptional regulator CSC00_4433 ENOG4105DMF Dehydrogenase CSC00_4434 ENOG4105KBX Transcriptional regulator, TetR family CSC00_4438 ENOG4108Z4V iron-sulfur cluster assembly CSC00_4439 ENOG4105DIW FeS assembly protein SUFB CSC00_4440 ENOG4105C3K feS assembly ATPase SufC CSC00_4441 ENOG4105JRK feS assembly protein SufD CSC00_4442 ENOG4105C9B Cysteine desulfurase CSC00_4443 ENOG4105C9B Cysteine desulfurase CSC00_4444 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) CSC00_4445 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CSC00_4447 ENOG4105CA9 Pyruvate kinase CSC00_4450 ENOG4105RFR Protein of unknown function (DUF2767) CSC00_4453 ENOG4105DJB Major Facilitator Superfamily CSC00_4454 ENOG4105E2X shikimate dehydrogenase CSC00_4455 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein CSC00_4456 ENOG4108W0P ABC transporter CSC00_4457 ENOG4105EHG Permease protein CSC00_4458 ENOG4105S10 periplasmic binding protein CSC00_4459 ENOG4108K2P TRANSCRIPTIONal CSC00_4460 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase CSC00_4461 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) CSC00_4462 ENOG4107UB2 Alpha beta hydrolase fold CSC00_4463 ENOG4105IKQ hydratase CSC00_4464 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) CSC00_4465 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) CSC00_4466 ENOG4108SC4 )-transporter CSC00_4469 ENOG4108T2C cysteine dioxygenase type I CSC00_4470 ENOG4106KR7 LysR family Transcriptional regulator CSC00_4471 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CSC00_4475 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CSC00_4476 ENOG4108IY8 ABC, transporter CSC00_4478 ENOG4105E0A ABC, transporter CSC00_4479 ENOG4105DQ5 transport system permease protein CSC00_4484 ENOG4106PMH Extracellular solute-binding protein family 3 CSC00_4485 ENOG4105E5Q amino acid AbC transporter CSC00_4486 ENOG4105CDA abc transporter atp-binding protein CSC00_4489 ENOG41083G8 Multidrug resistance protein MdtM CSC00_4492 ENOG4105CH2 amidohydrolase CSC00_4493 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CSC00_4494 ENOG4105DG4 malate L-lactate dehydrogenase CSC00_4496 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC CSC00_4497 ENOG4107Z33 ABC transporter, permease CSC00_4505 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) CSC00_4506 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) CSC00_4507 ENOG41060IM Heme exporter protein CSC00_4510 ENOG4105DA4 cytochrome c-type biogenesis protein CSC00_4511 ENOG4107QX9 Thiol disulfide interChange protein CSC00_4512 ENOG4105KWW Biogenesis protein CSC00_4514 ENOG4105E7U AraC family transcriptional regulator CSC00_4519 ENOG4105CHR reductase CSC00_4520 ENOG4105C7K acetolactate synthase CSC00_4523 ENOG4105DTD Dehydrogenase CSC00_4524 ENOG4105CY2 Citrate transporter CSC00_4525 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) CSC00_4526 ENOG4105CHU acetyl-coa acetyltransferase CSC00_4527 ENOG4107QNJ CoA-transferase subunit B CSC00_4529 ENOG4106NZI LysR family Transcriptional regulator CSC00_4534 ENOG4105CQB FAD linked oxidase domain protein CSC00_4535 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CSC00_4539 ENOG4105KME endoribonuclease L-psp CSC00_4540 ENOG4107TTD cytosine deaminase CSC00_4542 ENOG4105EMY transcriptional regulator CSC00_4551 ENOG4108JQ7 (ABC) transporter CSC00_4552 ENOG4105C3U ABC transporter CSC00_4557 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase CSC00_4558 ENOG4105E98 transcriptional regulator DeoR family CSC00_4560 ENOG4107B2H carbonic anhydrase CSC00_4565 ENOG4105CY0 Metallo-Beta-Lactamase CSC00_4570 ENOG4105F2I Transposase CSC00_4574 ENOG4108URH decarboxylase CSC00_4576 ENOG4107QI1 Mate efflux family protein CSC00_4577 ENOG4108R6K riboflavin synthase, subunit alpha CSC00_4578 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CSC00_4579 ENOG4105CZQ inner membrane transport protein YdhC CSC00_4580 ENOG4105ETE Transcriptional regulator (LacI family CSC00_4581 ENOG4105F27 Major Facilitator CSC00_4582 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CSC00_4584 ENOG4105K4H Nlp p60 protein CSC00_4585 ENOG4105M2J Glutaredoxin CSC00_4586 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) CSC00_4587 ENOG4108UYE Lactoylglutathione lyase CSC00_4588 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CSC00_4589 ENOG4108WUH Transcriptional regulator, TetR family CSC00_4590 ENOG4105XZD Fe-S protein CSC00_4591 ENOG4107RGM aldo keto reductase CSC00_4592 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CSC00_4593 ENOG4105DSW Fusaric acid resistance protein CSC00_4594 ENOG4105Y49 secretion protein, HlyD family CSC00_4597 ENOG4105BZU Histidine kinase CSC00_4598 ENOG4108XTF Outer Membrane Lipoprotein CSC00_4599 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CSC00_4600 ENOG410642K Lysozyme inhibitor CSC00_4601 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) CSC00_4602 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CSC00_4603 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) CSC00_4604 ENOG4108K3A Glutathione S-transferase CSC00_4607 ENOG4105CSM endonuclease III CSC00_4609 ENOG4108UQQ Electron transport complex CSC00_4614 ENOG4105M9B inner membrane protein ydgK CSC00_4616 ENOG4105CS2 ec 3.2.1.21 CSC00_4617 ENOG4105D9R oxidoreductase CSC00_4618 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CSC00_4619 ENOG4105EQ0 Major Facilitator superfamily CSC00_4620 ENOG4107YPT transcriptional regulator CSC00_4623 ENOG4105CPW cytochrome b561 CSC00_4628 ENOG4105DDW LysR family Transcriptional regulator CSC00_4630 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha CSC00_4631 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta CSC00_4632 ENOG4105E32 cytoplasmic protein CSC00_4633 ENOG4105EBR Carboxylesterase CSC00_4636 ENOG4108Z9I -acetyltransferase CSC00_4637 ENOG4107WE3 acetyltransferase YdcK CSC00_4638 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein CSC00_4639 ENOG41088CC tellurite resistance protein tehB CSC00_4641 ENOG4108KKZ (LipO)protein CSC00_4643 ENOG4105UEI Transcriptional Regulator AraC Family CSC00_4644 ENOG4105DKK Benzoate CSC00_4645 ENOG4108JCI Transcriptional regulator CSC00_4647 ENOG4105CFP Peptidase U32 CSC00_4651 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CSC00_4652 ENOG4105C4M (Ubiquinol oxidase) subunit I CSC00_4653 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CSC00_4654 ENOG4107TYH extracellular solute-binding protein family 1 CSC00_4655 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CSC00_4656 ENOG4105D81 ABC transporter, permease CSC00_4657 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component CSC00_4658 ENOG4105C26 Dehydrogenase CSC00_4661 ENOG410654E Membrane CSC00_4662 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 CSC00_4665 ENOG4105DEF Extracellular solute-binding protein, family 5 CSC00_4666 ENOG4105R71 cytoplasmic protein CSC00_4667 ENOG4108T9Y Inner membrane protein ydcZ CSC00_4668 ENOG4108Z7F N-acetyltransferase CSC00_4670 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CSC00_4671 ENOG4105DU0 nucleoside hydrolase CSC00_4673 ENOG41065TG regulatoR CSC00_4674 ENOG4105CI2 imidazolone-5-propionate hydrolase CSC00_4675 ENOG4105CHB tonB-dependent Receptor CSC00_4676 ENOG4108NS2 receptor CSC00_4678 ENOG4105C85 amino acid CSC00_4679 ENOG4105EQ2 LysR family Transcriptional regulator CSC00_4680 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CSC00_4681 ENOG4105DEN Luciferase family CSC00_4682 ENOG4105CH2 amidohydrolase CSC00_4684 ENOG4105EAB amino acid AbC transporter CSC00_4686 ENOG4105DRP amino acid AbC transporter CSC00_4687 ENOG4105CDA abc transporter atp-binding protein CSC00_4689 ENOG4108N27 Glutathione S-transferase CSC00_4692 ENOG4105CT4 transporter CSC00_4695 ENOG4108MEJ flavin reductase domain protein CSC00_4696 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CSC00_4697 ENOG4105C4Y ABC transporter CSC00_4698 ENOG4107RCV ABC transporter, permease CSC00_4699 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CSC00_4700 ENOG4105D0D Nitrate reductase 2, gamma subunit CSC00_4701 ENOG4108NZN Respiratory nitrate reductase 2 delta chain CSC00_4702 ENOG4108IUE nitrate reductase beta subunit CSC00_4703 ENOG4105CRU nitrate reductase, alpha subunit CSC00_4704 ENOG4107QND Nitrite extrusion protein CSC00_4707 ENOG4107HP6 Transcriptional regulator CSC00_4708 ENOG4105DTQ mandelate racemase muconate lactonizing CSC00_4709 ENOG4105NN7 muconolactone delta-isomerase CSC00_4710 ENOG410626B catechol 1,2-dioxygenase CSC00_4712 ENOG4108UKV benzoate 1,2-dioxygenase CSC00_4716 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CSC00_4717 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CSC00_4718 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CSC00_4719 ENOG4108MG3 formate dehydrogenase CSC00_4722 ENOG4105CSR polyphosphate kinase 2 CSC00_4724 ENOG4105F27 Major Facilitator CSC00_4727 ENOG4108JQ6 ABC transporter CSC00_4728 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSC00_4731 ENOG4105DQ4 alcohol dehydrogenase CSC00_4735 ENOG4105C5H ABC transporter CSC00_4737 ENOG4107R1I NAD-dependent malic enzyme CSC00_4741 ENOG4105JQN Transcriptional regulator CSC00_4742 ENOG4105N0E Protein of unknown function (DUF2543) CSC00_4743 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CSC00_4746 ENOG4108N8X transition metal ion binding CSC00_4748 ENOG4105CG3 alpha amylase, catalytic region CSC00_4752 ENOG4105F2I Transposase CSC00_4753 ENOG4108YDI single-species biofilm formation on inanimate substrate CSC00_4755 ENOG4108Z9K Osmotically inducible protein CSC00_4758 ENOG41076HS cation diffusion facilitator family transporter CSC00_4759 ENOG4105FFC UPF0187 protein CSC00_4760 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit CSC00_4761 ENOG4105C5Q Transcriptional regulator CSC00_4762 ENOG4108KUU Inner membrane metabolite transport protein ydjE CSC00_4763 ENOG4105KT7 mgtC SapB transporter CSC00_4764 ENOG4105D6Z AFG1 family ATPase CSC00_4765 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) CSC00_4766 ENOG4106KR7 LysR family Transcriptional regulator CSC00_4770 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CSC00_4771 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF CSC00_4772 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E CSC00_4774 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) CSC00_4775 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) CSC00_4776 ENOG4108IGT Dipeptidase CSC00_4777 ENOG4108J2P Alpha beta hydrolase fold CSC00_4778 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CSC00_4779 ENOG4105E0F Histidine kinase CSC00_4782 ENOG4105DY8 decarboxylase CSC00_4783 ENOG4108JPW Aminotransferase CSC00_4784 ENOG4107Z6I Thiamine biosynthesis protein CSC00_4785 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component CSC00_4786 ENOG4108YI8 ABC transporter CSC00_4787 ENOG4105ETU transcriptional activator (TenA CSC00_4789 ENOG4105CIB oxidoreductase Domain protein CSC00_4791 ENOG4105ETE Transcriptional regulator (LacI family CSC00_4792 ENOG4105BZU Histidine kinase CSC00_4793 ENOG4107QUY Guanine deaminase CSC00_4794 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease CSC00_4806 ENOG41089BK Glutamine amido-transferase CSC00_4807 ENOG4105R1U AraC Family Transcriptional Regulator CSC00_4810 ENOG4105CMU LysR family (Transcriptional regulator CSC00_4813 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CSC00_4817 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CSC00_4822 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CSC00_4827 ENOG4105E5Q amino acid AbC transporter CSC00_4829 ENOG4105C5R Aminotransferase CSC00_4832 ENOG4105CBN LysR family transcriptional regulator CSC00_4834 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CSC00_4835 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain CSC00_4836 ENOG4105CSH Transporter CSC00_4842 ENOG4105FCD Major Facilitator CSC00_4844 ENOG4105ETE Transcriptional regulator (LacI family CSC00_4845 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia CSC00_4847 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC CSC00_4848 ENOG4105UP7 3-epimerase CSC00_4851 ENOG4108YRF PTS System CSC00_4852 ENOG4105DM4 PTS System CSC00_4853 ENOG410829K Lysine exporter protein (Lyse ygga) CSC00_4855 ENOG4105CBN LysR family transcriptional regulator CSC00_4856 ENOG4105HEI LysR family (Transcriptional regulator CSC00_4859 ENOG4107PP3 Acetylornithine deacetylase CSC00_4862 ENOG4105CNN ABC, transporter CSC00_4863 ENOG4105C2J ABC transporter CSC00_4864 ENOG4105ETE Transcriptional regulator (LacI family CSC00_4870 ENOG4109066 lysm domain bon superfamily protein CSC00_4871 ENOG4105CXY transporter CSC00_4872 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC CSC00_4874 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta CSC00_4875 ENOG4105RHY Pfam:UPF0157 CSC00_4877 ENOG4105EQ2 LysR family Transcriptional regulator CSC00_4878 ENOG4105CPC Aldo Keto reductase CSC00_4879 ENOG4107SET aldo keto reductase CSC00_4880 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis CSC00_4881 ENOG4105CPC Aldo Keto reductase CSC00_4889 ENOG4105ENX hydrolase CSC00_4892 ENOG4105MVE transcriptional regulator CSC00_4893 ENOG4105CMG Carbohydrate kinase CSC00_4894 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CSC00_4895 ENOG4105E98 transcriptional regulator DeoR family CSC00_4896 ENOG4105UP7 3-epimerase CSC00_4897 ENOG4108RVA ribokinase CSC00_4898 ENOG4105EDR glucose galactose transporter CSC00_4901 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) CSC00_4902 ENOG4105CHR reductase CSC00_4903 ENOG4105CHU acetyl-coa acetyltransferase CSC00_4907 ENOG4105BZW Glycerate kinase CSC00_4908 ENOG4107VHA regulatoR CSC00_4910 ENOG4105JQN Transcriptional regulator CSC00_4912 ENOG4107YCY Transcriptional regulator CSC00_4913 ENOG4105CI1 PTS System CSC00_4914 ENOG4105F8D glycoside hydrolase family 4 CSC00_4916 ENOG4105C54 Major Facilitator superfamily CSC00_4917 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CSC00_4920 ENOG4105NIV Esterase CSC00_4921 ENOG4105BZU Histidine kinase CSC00_4924 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CSC00_4927 ENOG4108VCD Chaperone CSC00_4928 ENOG4105CW0 outer membrane usher protein CSC00_4930 ENOG4105F32 YngK protein CSC00_4931 ENOG4105CAF HipA N-terminal domain protein CSC00_4932 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein CSC00_4933 ENOG4105VT2 5-hydroxyisourate hydrolase CSC00_4934 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) CSC00_4935 ENOG4105C2W permease CSC00_4936 ENOG41061H0 Monooxygenase CSC00_4937 ENOG4108KSA LysR family transcriptional regulator CSC00_4944 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions CSC00_4947 ENOG4105VYA Uncharacterized conserved protein (DUF2132) CSC00_4949 ENOG4105D01 (LipO)protein CSC00_4951 ENOG4108UMI ABC transporter, permease CSC00_4952 ENOG4105EA8 2-Nitropropane dioxygenase CSC00_4953 ENOG4105EGI Transcriptional regulator CSC00_4954 ENOG4105CBP Major Facilitator CSC00_4956 ENOG4105F9N Major Facilitator Superfamily CSC00_4966 ENOG4107QZW Altronate oxidoreductase CSC00_4968 ENOG4105BZU Histidine kinase CSC00_4969 ENOG4105M0C cytoplasmic protein CSC00_4970 ENOG4105CSV Glutaminase CSC00_4971 ENOG4105C26 Dehydrogenase CSC00_4972 ENOG4105EGI Transcriptional regulator CSC00_4974 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CSC00_4975 ENOG4105MVE transcriptional regulator CSC00_4976 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) CSC00_4977 ENOG4107S2N Type III effector Hrp-dependent CSC00_4978 ENOG4105C0A alcohol dehydrogenase CSC00_4979 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CSC00_4982 ENOG4108R66 Conserved Protein CSC00_4983 ENOG4105CHR reductase CSC00_4984 ENOG4105JAB phenazine biosynthesis protein, phzf family CSC00_4985 ENOG4105F27 Major Facilitator CSC00_4986 ENOG41082NP Multiple antibiotic resistance CSC00_4988 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes CSC00_4989 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF CSC00_4990 ENOG4106DNR multiple antibiotic resistance protein CSC00_4991 ENOG4108594 Permease of the drug metabolite transporter CSC00_4992 ENOG4105E5W Transporter CSC00_4994 ENOG4108IV0 ABC, transporter CSC00_4996 ENOG4105CNN ABC, transporter CSC00_4997 ENOG4105C32 Amino acid ABC transporter (Permease) CSC00_4998 ENOG41083Z3 extracellular ligand-binding receptor CSC00_5001 ENOG4105ECQ AraC Family Transcriptional Regulator CSC00_5005 ENOG4105ETE Transcriptional regulator (LacI family CSC00_5006 ENOG4105CNT hydrolase family 2 CSC00_5007 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) CSC00_5008 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CSC00_5010 ENOG4108J4B Beta-lactamase CSC00_5011 ENOG4105MVE transcriptional regulator CSC00_5013 ENOG4105G63 Type III effector Hrp-dependent CSC00_5014 ENOG4105FB2 class II Aldolase CSC00_5015 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) CSC00_5016 ENOG4105C6Z Gluconate CSC00_5018 ENOG4105F2I Transposase CSC00_5021 ENOG4105BZU Histidine kinase CSC00_5022 ENOG4108WTK competence damage-inducible protein CSC00_5023 ENOG4108ZNX Heat shock protein CSC00_5025 ENOG4108WQH regulatoR CSC00_5028 ENOG4108RAV Conserved protein CSC00_5029 ENOG4105R1U AraC Family Transcriptional Regulator CSC00_5032 ENOG4105DGW oligopeptidase A CSC00_5033 ENOG4105EMU Dehydrogenase CSC00_5034 ENOG4107XBN GntR Family Transcriptional Regulator CSC00_5035 ENOG4108U51 Universal stress protein CSC00_5036 ENOG4105DEI Mannitol dehydrogenase CSC00_5037 ENOG4108I5G Major Facilitator superfamily CSC00_5038 ENOG4105KK4 UPF0060 membrane protein CSC00_5039 ENOG4105M5Q UPF0482 protein CSC00_5040 ENOG4108MK9 spermidine N(1)-acetyltransferase CSC00_5042 ENOG4105KBG Protein of unknown function (DUF1161) CSC00_5043 ENOG4107QY8 reductase CSC00_5044 ENOG4105QAX Iron-sulfur CSC00_5045 ENOG4107KGK dmso reductase anchor subunit CSC00_5046 ENOG4108NEM leader-binding protein dmsD CSC00_5047 ENOG4105CMQ Chloride channel CSC00_5048 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CSC00_5049 ENOG4105DAG ROK family CSC00_5050 ENOG4106NZI LysR family Transcriptional regulator CSC00_5051 ENOG4105D94 Major Facilitator Superfamily CSC00_5052 ENOG4105CTD carboxy-peptidase CSC00_5055 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap CSC00_5057 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) CSC00_5058 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) CSC00_5059 ENOG4105DSF transport protein CSC00_5065 ENOG4107TT2 Auxin Efflux Carrier CSC00_5066 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase CSC00_5067 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CSC00_5068 ENOG4108K70 Transcriptional regulator CSC00_5069 ENOG4105DWT malate dehydrogenase (quinone) CSC00_5070 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CSC00_5072 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CSC00_5073 ENOG4108MRH transcriptional regulatory protein CSC00_5078 ENOG4107GFK fumarate CSC00_5080 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase CSC00_5081 ENOG4105F2Z 3-oxoadipate enol-lactonase CSC00_5082 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase CSC00_5083 ENOG4105CHU acetyl-coa acetyltransferase CSC00_5084 ENOG4107QNJ CoA-transferase subunit B CSC00_5086 ENOG4107HP6 Transcriptional regulator CSC00_5087 ENOG4108DG9 Smr protein MutS2 CSC00_5088 ENOG4106KR7 LysR family Transcriptional regulator CSC00_5090 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B CSC00_5091 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B CSC00_5092 ENOG4105CFC Transporter CSC00_5094 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CSC00_5095 ENOG4105DS0 Transcriptional regulator, Crp Fnr family CSC00_5096 ENOG4105Q9Y Universal stress protein CSC00_5097 ENOG410671Z uncharacterized protein ydiH CSC00_5098 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CSC00_5099 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CSC00_5102 ENOG4105C5D exported protein CSC00_5103 ENOG4105D5Q Arginine ornithine antiporter CSC00_5104 ENOG410642E Short chain dehydrogenase CSC00_5105 ENOG4105RA2 Membrane CSC00_5106 ENOG4107EXC regulatoR CSC00_5108 ENOG4105JJR Histidine kinase CSC00_5110 ENOG4105C9Q fumarate hydratase class II CSC00_5111 ENOG4107GFK fumarate CSC00_5112 ENOG4105EIP mannose-6-phosphate isomerase CSC00_5113 ENOG4106J39 exported protein CSC00_5114 ENOG4107P2S Transcriptional regulator CSC00_5115 ENOG4105CI1 PTS System CSC00_5116 ENOG4105C87 Aminotransferase class I and II CSC00_5118 ENOG41061EV selenium-binding protein YdfZ CSC00_5121 ENOG41066VF YeeE YedE family protein CSC00_5122 ENOG4105KSU Redox protein CSC00_5123 ENOG41064WM Uncharacterized protein YcgX CSC00_5124 ENOG4105VPI YqaE family transport protein CSC00_5125 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CSC00_5126 ENOG4105C26 Dehydrogenase CSC00_5128 ENOG4107DB1 DUF218 domain CSC00_5129 ENOG4105CSH Transporter CSC00_5131 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) CSC00_5132 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) CSC00_5133 ENOG4105C26 Dehydrogenase CSC00_5134 ENOG4105F4X arginine CSC00_5135 ENOG4105C8Y Acetylornithine aminotransferase CSC00_5138 ENOG4105D82 Glutamate dehydrogenase CSC00_5139 ENOG4108FN7 Aldo keto reductase CSC00_5140 ENOG410642W LysR family Transcriptional regulator CSC00_5144 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CSC00_5146 ENOG4105CQ7 ATP-dependent helicase CSC00_5147 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CSC00_5149 ENOG4108Z0R Transferase CSC00_5150 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein CSC00_5151 ENOG4105DZS Phenylacetate-CoA ligase CSC00_5152 ENOG4105CHU acetyl-coa acetyltransferase CSC00_5153 ENOG4108ZJI phenylacetic acid degradation protein CSC00_5154 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CSC00_5155 ENOG4108UKI Enoyl-CoA hydratase CSC00_5156 ENOG4105E39 Enoyl-CoA hydratase CSC00_5157 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CSC00_5158 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit CSC00_5159 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit CSC00_5160 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit CSC00_5161 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit CSC00_5162 ENOG4105DXM phenylacetic acid degradation protein CSC00_5163 ENOG4105F11 amine oxidase CSC00_5166 ENOG4105C26 Dehydrogenase CSC00_5167 ENOG4108WFR AraC Family Transcriptional Regulator CSC00_5168 ENOG4105WXT Conserved Protein CSC00_5169 ENOG410689M (LipO)protein CSC00_5170 ENOG4107H52 Dicarboxylate transport CSC00_5171 ENOG4108KF1 Membrane CSC00_5172 ENOG4105C5I Dehydrogenase CSC00_5173 ENOG41090X5 Heat shock protein hslJ CSC00_5175 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) CSC00_5176 ENOG4105FCK Membrane CSC00_5178 ENOG4108RW8 Universal stress protein F CSC00_5180 ENOG4105C1J atp-dependent rna helicase CSC00_5181 ENOG4107RX3 Mg2 transporter protein cora family protein CSC00_5182 ENOG4105E98 transcriptional regulator DeoR family CSC00_5183 ENOG4105D9R oxidoreductase CSC00_5186 ENOG4105C85 amino acid CSC00_5187 ENOG4105F7P transcriptional regulator AsnC family CSC00_5189 ENOG4105CGF Aromatic amino acid aminotransferase CSC00_5190 ENOG4108UMI ABC transporter, permease CSC00_5192 ENOG4105D01 (LipO)protein CSC00_5194 ENOG4105EE1 crotonyl-CoA reductase CSC00_5199 ENOG4105HEI LysR family (Transcriptional regulator CSC00_5204 ENOG4108XFH Transcriptional regulator CSC00_5205 ENOG4105F6U Short-chain dehydrogenase reductase Sdr CSC00_5224 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CSC00_5226 ENOG4108ZG0 Ompa motb domain protein CSC00_5232 ENOG4106FE3 DNA repair CSC00_5249 ENOG4105E4C Lytic transglycosylase catalytic CSC00_5253 ENOG4105MP0 transposase CSC00_5264 ENOG4107ZQ5 Phage-associated protein, HI1409 family CSC00_5265 ENOG4108N0N Phage Terminase Large Subunit CSC00_5272 ENOG4105HGD Antitermination protein CSC00_5290 ENOG4105DFP Integrase CSC00_5291 ENOG4108Z0Z intracellular protease Pfpi family CSC00_5294 ENOG4105CBN LysR family transcriptional regulator CSC00_5298 ENOG4107RTG Major Facilitator superfamily CSC00_5299 ENOG4105ENX hydrolase CSC00_5300 ENOG4105EQ2 LysR family Transcriptional regulator CSC00_5303 ENOG4107QSI ABC, transporter CSC00_5305 ENOG4105KXI murein peptide amidase A CSC00_5306 ENOG4107S8C mandelate racemase muconate lactonizing CSC00_5307 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CSC00_5308 ENOG4108KK1 membrane protein AbrB duplication CSC00_5309 ENOG4108JU8 Transcriptional regulator CSC00_5310 ENOG4105F8D glycoside hydrolase family 4 CSC00_5311 ENOG4105W8I Transcriptional regulator CSC00_5312 ENOG4106K28 UPF0283 membrane protein CSC00_5313 ENOG4105CM6 amino acid regulated cytosolic protein CSC00_5314 ENOG4105NNG Peripheral inner membrane phage-shock protein CSC00_5315 ENOG4105FM1 phage shock protein C CSC00_5316 ENOG4105YYT phage shock protein B CSC00_5317 ENOG41087YS Phage shock protein A CSC00_5318 ENOG4105E51 psp operon transcriptional activator CSC00_5320 ENOG4105CH2 amidohydrolase CSC00_5321 ENOG41063ZK Transcriptional Regulator AraC Family CSC00_5324 ENOG4108J59 Extracellular solute-binding protein, family 5 CSC00_5325 ENOG4108I5W peptide transport system, permease protein CSC00_5326 ENOG4108RAV Conserved protein CSC00_5329 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CSC00_5330 ENOG4105KT5 UmuD protein CSC00_5331 ENOG4105EKQ RNA-directed DNA polymerase CSC00_5339 ENOG4105BZU Histidine kinase CSC00_5344 ENOG4108ZSJ is1 orf2 CSC00_5346 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CSC00_5347 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A CSC00_5362 ENOG4105EKQ RNA-directed DNA polymerase CSC00_5378 ENOG4105D5G Transposase CSC00_5379 ENOG4105F2I Transposase CSC00_5381 ENOG4105EMU Dehydrogenase CSC00_5392 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CSC00_5398 ENOG410600T transposase CSC00_5408 ENOG4105GR3 Histidine kinase CSC00_5409 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSC00_5410 ENOG4108PG2 copper resistance CSC00_5411 ENOG4105JDN Copper resistance protein CSC00_5412 ENOG4105VR0 copper resistance CSC00_5413 ENOG4105E3B Multicopper oxidase CSC00_5415 ENOG4105DR5 peptidase CSC00_5421 ENOG410624V efflux system protein CSC00_5428 ENOG4108ZSJ is1 orf2 CSC00_5429 ENOG4108ZQS transposase CSC00_5430 ENOG4108MVM Transposase CSC00_5432 ENOG4105C94 Transporter CSC00_5433 ENOG4105EXU Membrane CSC00_5434 ENOG4108M8H domain protein CSC00_5436 ENOG410620I Diguanylate cyclase CSC00_5438 ENOG4106JVB Replication Protein CSC00_5439 ENOG4105EZN Cobyrinic acid ac-diamide synthase CSC00_5440 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB CSC00_5442 ENOG4105D7V transposase CSC00_5443 ENOG4105D7V transposase CSC00_5447 ENOG4105EKQ RNA-directed DNA polymerase CSC00_5458 ENOG4105FEQ ParB domain protein nuclease CSC00_5468 ENOG4108Z3N Transcriptional regulator CSC00_5502 ENOG4107CBI conjugal transfer fertility inhibition protein CSC00_5506 ENOG4108MA7 Inherit from COG: YD repeat protein CSC00_5508 ENOG4106CQM replication CSC00_5514 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) CSC00_5516 ENOG4105ETE Transcriptional regulator (LacI family CSC00_5518 ENOG4105CIS alcohol dehydrogenase CSC00_5521 ENOG4108YXQ IS66 Orf2 family protein CSC00_5522 ENOG4105E0A ABC, transporter CSC00_5523 ENOG4108IHU transport system permease protein CSC00_5524 ENOG4105DQ5 transport system permease protein CSC00_5525 ENOG4108HUF Transporter CSC00_5526 ENOG4105GAV receptor CSC00_5527 ENOG4108S3W Anti-feci sigma factor, fecr CSC00_5528 ENOG4108SF5 RNA Polymerase CSC00_5533 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSC00_5534 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSC00_5537 ENOG4108JQ6 ABC transporter CSC00_5538 ENOG4105E5H Transposase CSC00_5539 ENOG4105E5H Transposase CSC00_5541 ENOG4108YXQ IS66 Orf2 family protein CSC00_5545 ENOG4108MBK is1 orf2 CSC00_5554 ENOG4105MP0 transposase CSC00_5559 ENOG4105VUN Transcriptional regulator CSC00_5575 ENOG4105F2I Transposase CSC00_5576 ENOG4105F2I Transposase CSC00_5580 ENOG4105VN1 Heat shock protein CSC00_5581 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CSC00_5584 ENOG4105D0M Protease HtpX homolog CSC00_5590 ENOG4105KF5 hemolysin expression-modulating protein CSC00_5604 ENOG4105CAU Arsenical resistance protein, ArsH CSC00_5607 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CSC00_5635 ENOG4105C4R Atp-dependent dna helicase CSC00_5648 ENOG4105EKQ RNA-directed DNA polymerase CSC00_5655 ENOG4106JVB Replication Protein CSC00_5673 ENOG4105T95 Thiol disulfide interChange protein CSC00_5700 ENOG4105EKQ RNA-directed DNA polymerase CSC00_5702 ENOG4105D7V transposase CSC00_5726 ENOG4106JVB Replication Protein CSC00_5737 ENOG4106CVF DNA replication protein CSC00_5762 ENOG4105EQR Transposase IS116 IS110 IS902 CSC00_5792 ENOG4108NYK Tape measure protein CSC00_5808 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CSC00_5809 ENOG4105FA0 parb-like partition protein CSC00_5828 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CSC00_5831 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CSC00_5852 ENOG4105D5M phosphate starvation-inducible protein CSC00_5853 ENOG41090BQ Glutaredoxin CSC00_5860 ENOG4106J5W DNA polymerase III (alpha subunit) CSC00_5865 ENOG4105C2M dna polymerase I CSC00_5867 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CSC00_5871 ENOG4106JVB Replication Protein CSC00_5898 ENOG4107XMK single-stranded DNA-binding protein CSC00_5906 ENOG4105KF5 hemolysin expression-modulating protein