locus-tag	class	description
HC680_00020	COG0187	DNA topoisomerase II activity
HC680_00025	COG0561	phosphatase activity
HC680_00040	COG2186	Transcriptional regulator
HC680_00045	COG3734	2-keto-3-deoxy-galactonokinase
HC680_00050	COG0800	Aldolase
HC680_00060	COG2271	Major facilitator Superfamily
HC680_00065	COG0823	Involved in the tonB-independent uptake of proteins
HC680_00070	COG5645	(Lipo)protein
HC680_00095	COG2188	Transcriptional regulator
HC680_00110	COG2149	membrane
HC680_00130	COG2610	gluconate transmembrane transporter activity
HC680_00140	COG0583	DNA-binding transcription factor activity
HC680_00145	COG2814	Major facilitator Superfamily
HC680_00175	COG0028	Belongs to the TPP enzyme family
HC680_00180	COG0440	acetolactate synthase activity
HC680_00185	COG2197	response regulator
HC680_00195	COG2271	Major facilitator Superfamily
HC680_00235	COG2188	Transcriptional regulator
HC680_00260	COG4580	involved in the transport of maltose and maltodextrins
HC680_00265	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC680_00270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC680_00270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC680_00280	COG1609	Transcriptional regulator
HC680_00290	COG3384	dioxygenase
HC680_00295	COG0583	DNA-binding transcription factor activity
HC680_00300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC680_00305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HC680_00310	COG2828	Protein conserved in bacteria
HC680_00325	COG0697	spore germination
HC680_00330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC680_00330	COG1263	PTS System
HC680_00340	COG2814	Major facilitator Superfamily
HC680_00350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC680_00385	COG0583	DNA-binding transcription factor activity
HC680_00410	COG1464	Belongs to the NlpA lipoprotein family
HC680_00425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HC680_00435	COG1064	alcohol dehydrogenase
HC680_00465	COG2211	Major facilitator Superfamily
HC680_00470	COG1501	Belongs to the glycosyl hydrolase 31 family
HC680_00480	COG1486	melibiose metabolic process
HC680_00485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC680_00485	COG1263	PTS System
HC680_00490	COG2982	Protein involved in outer membrane biogenesis
HC680_00495	COG2233	PERMEase
HC680_00500	COG0786	glutamate:sodium symporter activity
HC680_00520	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HC680_00545	COG3152	Membrane
HC680_00555	COG1494	fructose-1,6-bisphosphatase
HC680_00560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HC680_00565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC680_00570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC680_00590	COG2860	membrane
HC680_00600	COG2169	Transcriptional regulator
HC680_00600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC680_00605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HC680_00615	COG1561	YicC-like family, N-terminal region
HC680_00640	COG1131	(ABC) transporter
HC680_00645	COG0842	Transport permease protein
HC680_00670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC680_00705	COG1519	Transferase
HC680_00710	COG1216	Glycosyl transferase, family 2
HC680_00715	COG0438	transferase activity, transferring glycosyl groups
HC680_00725	COG0859	PFAM glycosyl transferase family 9
HC680_00735	COG1216	Glycosyl transferase, family 2
HC680_00735	COG1442	glycosyl transferase family 8
HC680_00740	COG3307	-O-antigen
HC680_00745	COG0438	transferase activity, transferring glycosyl groups
HC680_00750	COG0859	PFAM glycosyl transferase family 9
HC680_00765	COG0156	8-amino-7-oxononanoate synthase activity
HC680_00775	COG0463	Glycosyl transferase, family 2
HC680_00780	COG2861	carbohydrate metabolic process
HC680_00785	COG4942	peptidase
HC680_00795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC680_00800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HC680_00820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HC680_00830	COG2186	Transcriptional regulator
HC680_00850	COG3722	fumarate hydratase activity
HC680_00870	COG1566	PFAM secretion protein HlyD family protein
HC680_00875	COG0625	glutathione transferase activity
HC680_00885	COG3276	selenocysteine insertion sequence binding
HC680_00890	COG1414	Transcriptional regulator
HC680_00895	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HC680_00900	COG3977	Valine--pyruvate aminotransferase
HC680_00905	COG0366	Alpha amylase catalytic
HC680_00910	COG2992	FlgJ-related protein
HC680_00915	COG2207	Transcriptional regulator
HC680_00915	COG1609	Transcriptional regulator
HC680_00920	COG4214	carbohydrate transport
HC680_00930	COG4213	ABC transporter substrate-binding protein
HC680_00945	COG4682	membrane
HC680_00950	COG4682	membrane
HC680_00955	COG3274	enterobacterial common antigen metabolic process
HC680_01005	COG1278	Cold shock
HC680_01010	COG2944	sequence-specific DNA binding
HC680_01015	COG2814	Major facilitator Superfamily
HC680_01035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC680_01045	COG1609	Transcriptional regulator
HC680_01055	COG2885	chlorophyll binding
HC680_01060	COG0243	molybdopterin cofactor binding
HC680_01065	COG0456	acetyltransferase
HC680_01070	COG2818	Glycosylase
HC680_01075	COG5571	outer membrane autotransporter
HC680_01080	COG2223	nitrite transmembrane transporter activity
HC680_01105	COG0747	negative chemotaxis
HC680_01110	COG0601	transmembrane transport
HC680_01115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC680_01120	COG0444	Belongs to the ABC transporter superfamily
HC680_01125	COG4608	Belongs to the ABC transporter superfamily
HC680_01140	COG2894	cell division
HC680_01150	COG1215	transferase activity, transferring glycosyl groups
HC680_01155	COG0457	Tetratricopeptide repeat
HC680_01170	COG2194	sulfuric ester hydrolase activity
HC680_01200	COG1215	transferase activity, transferring glycosyl groups
HC680_01205	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HC680_01210	COG3118	belongs to the thioredoxin family
HC680_01210	COG0457	Tetratricopeptide repeat
HC680_01215	COG2200	EAL domain
HC680_01215	COG2199	diguanylate cyclase activity
HC680_01225	COG0612	Peptidase, M16
HC680_01240	COG2982	Protein involved in outer membrane biogenesis
HC680_01245	COG0477	Major facilitator Superfamily
HC680_01250	COG1295	ribonuclease BN
HC680_01255	COG0583	DNA-binding transcription factor activity
HC680_01260	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_01265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC680_01275	COG1454	alcohol dehydrogenase
HC680_01285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC680_01290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HC680_01295	COG0671	phosphoesterase, PA-phosphatase related
HC680_01315	COG0589	response to stress
HC680_01325	COG0306	phosphate transporter
HC680_01330	COG2081	HI0933 family
HC680_01335	COG2239	Acts as a magnesium transporter
HC680_01350	COG1124	(ABC) transporter
HC680_01360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC680_01365	COG0601	transmembrane transport
HC680_01370	COG0747	negative chemotaxis
HC680_01380	COG3479	Phenolic acid decarboxylase
HC680_01420	COG0628	permease
HC680_01425	COG0477	Major facilitator Superfamily
HC680_01435	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HC680_01450	COG3714	YhhN family
HC680_01460	COG3776	membrane
HC680_01465	COG0742	ribosomal rna small subunit methyltransferase
HC680_01470	COG0552	protein localization to endoplasmic reticulum
HC680_01475	COG2884	Cell division ATP-binding protein ftsE
HC680_01480	COG2177	Part of the ABC transporter FtsEX involved in
HC680_01495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC680_01505	COG0683	leucine binding
HC680_01515	COG0683	leucine binding
HC680_01520	COG0559	Belongs to the binding-protein-dependent transport system permease family
HC680_01570	COG0584	glycerophosphoryl diester phosphodiesterase
HC680_01580	COG0405	Gamma-glutamyltransferase
HC680_01585	COG1247	-acetyltransferase
HC680_01595	COG0673	inositol 2-dehydrogenase activity
HC680_01600	COG1741	Belongs to the pirin family
HC680_01605	COG1609	Transcriptional regulator
HC680_01610	COG3265	gluconokinase activity
HC680_01615	COG2610	gluconate transmembrane transporter activity
HC680_01625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HC680_01650	COG0058	SHG alpha-glucan phosphorylase activity
HC680_01655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HC680_01670	COG1349	DNA-binding transcription factor activity
HC680_01680	COG0058	SHG alpha-glucan phosphorylase activity
HC680_01685	COG1640	4-alpha-glucanotransferase
HC680_01690	COG2610	gluconate transmembrane transporter activity
HC680_01700	COG1040	competence protein
HC680_01725	COG1918	ferrous iron import across plasma membrane
HC680_01730	COG2183	response to ionizing radiation
HC680_01735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC680_01740	COG0745	RESPONSE REGULATOR receiver
HC680_01760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HC680_01765	COG1011	Hydrolase
HC680_01775	COG0494	nUDIX hydrolase
HC680_01780	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HC680_01805	COG4796	Type ii and iii secretion system protein
HC680_01820	COG3266	domain, Protein
HC680_01825	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HC680_01830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC680_01855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC680_01865	COG0402	S-adenosylhomocysteine deaminase activity
HC680_01870	COG0738	Major facilitator superfamily
HC680_01895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC680_01900	COG1289	transmembrane transporter activity
HC680_01910	COG1765	OsmC-like protein
HC680_01915	COG3954	Phosphoribulokinase
HC680_01925	COG0429	hydrolase of the alpha beta-hydrolase fold
HC680_01935	COG0488	(ABC) transporter
HC680_01950	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HC680_01955	COG1047	Peptidyl-prolyl cis-trans
HC680_01965	COG0545	Peptidyl-prolyl cis-trans isomerase
HC680_01970	COG2964	Protein conserved in bacteria
HC680_02015	COG0250	Participates in transcription elongation, termination and antitermination
HC680_02050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HC680_02055	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC680_02065	COG3706	GGDEF domain
HC680_02080	COG2104	thiamine diphosphate biosynthetic process
HC680_02085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC680_02100	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HC680_02135	COG3678	ATP-independent chaperone mediated protein folding
HC680_02140	COG4191	Histidine kinase
HC680_02150	COG0151	Belongs to the GarS family
HC680_02185	COG0456	acetyltransferase
HC680_02195	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HC680_02225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC680_02280	COG0527	aspartate kinase activity
HC680_02290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HC680_02300	COG0251	oxidation-reduction process
HC680_02370	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HC680_02380	COG0534	Mate efflux family protein
HC680_02390	COG3237	CsbD-like
HC680_02395	COG0735	belongs to the Fur family
HC680_02405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC680_02420	COG0305	Participates in initiation and elongation during chromosome replication
HC680_02425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC680_02440	COG0432	Pfam Uncharacterised protein family UPF0047
HC680_02445	COG2315	Protein conserved in bacteria
HC680_02460	COG0741	lytic transglycosylase activity
HC680_02470	COG4771	TonB-dependent receptor
HC680_02495	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC680_02505	COG0483	inositol monophosphate 1-phosphatase activity
HC680_02510	COG1609	Transcriptional regulator
HC680_02515	COG1234	tRNA 3'-trailer cleavage
HC680_02545	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HC680_02555	COG0789	Transcriptional regulator
HC680_02560	COG0625	glutathione transferase activity
HC680_02565	COG2252	PERMEase
HC680_02570	COG0025	NhaP-type Na H and K H
HC680_02575	COG0583	DNA-binding transcription factor activity
HC680_02580	COG1380	Effector of murein hydrolase LrgA
HC680_02585	COG1346	cytolysis
HC680_02595	COG3539	Fimbrial protein
HC680_02625	COG3162	membrane
HC680_02630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC680_02640	COG1301	dicarboxylic acid transport
HC680_02645	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HC680_02685	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC680_02690	COG1129	ABC transporter
HC680_02695	COG4191	Histidine kinase
HC680_02695	COG0784	Response regulator, receiver
HC680_02705	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HC680_02715	COG3454	Phosphonate metabolism
HC680_02720	COG4778	phosphonate C-P lyase system protein PhnL
HC680_02725	COG4107	phosphonate C-P lyase system protein PhnK
HC680_02730	COG3627	carbon phosphorus lyase activity
HC680_02735	COG3626	phosphonate metabolism
HC680_02740	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HC680_02745	COG3624	Phosphonate C-P lyase system protein PhnG
HC680_02750	COG2188	Transcriptional regulator
HC680_02755	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HC680_02760	COG2824	Alkylphosphonate utilization operon protein PhnA
HC680_02775	COG2169	Transcriptional regulator
HC680_02780	COG1486	melibiose metabolic process
HC680_02820	COG0861	Integral membrane protein TerC family
HC680_02840	COG1215	transferase activity, transferring glycosyl groups
HC680_02845	COG1649	PFAM Uncharacterised BCR, COG1649
HC680_02845	COG0726	polysaccharide deacetylase
HC680_02850	COG0457	Tetratricopeptide repeat
HC680_02885	COG1309	transcriptional regulator
HC680_02900	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HC680_02905	COG1027	Aspartate ammonia-lyase
HC680_02910	COG3030	protein affecting phage T7 exclusion by the F plasmid
HC680_02915	COG0531	amino acid
HC680_02980	COG1509	lysine 2,3-aminomutase activity
HC680_02995	COG5510	response to toxic substance
HC680_03000	COG2076	Multidrug Resistance protein
HC680_03020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HC680_03025	COG1053	succinate dehydrogenase
HC680_03040	COG3264	Mechanosensitive ion channel
HC680_03040	COG1511	domain protein
HC680_03060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC680_03080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HC680_03085	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HC680_03085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HC680_03090	COG0802	atpase or kinase
HC680_03095	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC680_03120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HC680_03125	COG0330	HflC and HflK could
HC680_03130	COG0330	HflC and HflK could
HC680_03140	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HC680_03155	COG0557	exoribonuclease II activity
HC680_03160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC680_03165	COG1960	acyl-CoA dehydrogenase activity
HC680_03175	COG3650	response to hydrogen peroxide
HC680_03180	COG1073	alpha beta
HC680_03240	COG2965	DNA replication, synthesis of RNA primer
HC680_03245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HC680_03255	COG3061	Opacity-associated protein A
HC680_03260	COG0545	Peptidyl-prolyl cis-trans isomerase
HC680_03265	COG1113	amino acid transport
HC680_03275	COG0697	spore germination
HC680_03285	COG0702	epimerase
HC680_03290	COG1733	regulation of RNA biosynthetic process
HC680_03305	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HC680_03330	COG1253	flavin adenine dinucleotide binding
HC680_03340	COG0729	surface antigen
HC680_03345	COG2911	Protein conserved in bacteria
HC680_03350	COG2105	PFAM AIG2 family protein
HC680_03365	COG1879	ABC-type sugar transport system periplasmic component
HC680_03370	COG1129	ABC transporter
HC680_03375	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC680_03380	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC680_03390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HC680_03415	COG0312	modulator of DNA gyrase
HC680_03450	COG3964	amidohydrolase
HC680_03465	COG2706	6-phosphogluconolactonase activity
HC680_03470	COG3711	transcriptional antiterminator
HC680_03470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_03475	COG3077	Addiction module antitoxin, RelB DinJ family
HC680_03480	COG2026	Addiction module toxin, RelE StbE family
HC680_03485	COG0602	queuosine metabolic process
HC680_03510	COG1486	melibiose metabolic process
HC680_03515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC680_03520	COG0366	Alpha amylase catalytic
HC680_03525	COG1263	PTS System
HC680_03525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC680_03560	COG2731	YhcH YjgK YiaL family protein
HC680_03570	COG2222	sugar isomerase
HC680_03575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC680_03580	COG1228	amidohydrolase
HC680_03585	COG1288	antiporter activity
HC680_03590	COG2188	Transcriptional regulator
HC680_03615	COG0525	valine-tRNA ligase activity
HC680_03620	COG2927	DNA polymerase III (CHI subunit)
HC680_03630	COG0795	lipopolysaccharide-transporting ATPase activity
HC680_03635	COG0795	lipopolysaccharide-transporting ATPase activity
HC680_03640	COG0433	COG0433 Predicted ATPase
HC680_03655	COG3718	enzyme involved in inositol metabolism
HC680_03660	COG1737	Transcriptional regulator
HC680_03660	COG0837	glucose binding
HC680_03665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC680_03675	COG3962	Belongs to the TPP enzyme family
HC680_03685	COG1082	Xylose isomerase domain protein TIM barrel
HC680_03695	COG1653	transport
HC680_03700	COG3842	ATPase activity
HC680_03705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HC680_03710	COG0395	ABC-type sugar transport system, permease component
HC680_03715	COG1175	transmembrane transport
HC680_03720	COG1064	alcohol dehydrogenase
HC680_03725	COG0659	secondary active sulfate transmembrane transporter activity
HC680_03730	COG0288	reversible hydration of carbon dioxide
HC680_03740	COG0582	viral genome integration into host DNA
HC680_03745	COG0515	serine threonine protein kinase
HC680_03745	COG2815	serine threonine protein kinase
HC680_03765	COG3039	Transposase
HC680_03815	COG1401	restriction endodeoxyribonuclease activity
HC680_03875	COG1216	Glycosyl transferase, family 2
HC680_03930	COG1176	ABC-type spermidine putrescine transport system, permease component I
HC680_03940	COG0584	glycerophosphoryl diester phosphodiesterase
HC680_03950	COG3507	Belongs to the glycosyl hydrolase 43 family
HC680_03955	COG2211	Major facilitator Superfamily
HC680_03960	COG2115	Belongs to the xylose isomerase family
HC680_03970	COG4580	involved in the transport of maltose and maltodextrins
HC680_03975	COG3272	Protein of unknown function (DUF1722)
HC680_03995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HC680_04010	COG0300	oxidoreductase activity
HC680_04020	COG0789	Transcriptional regulator
HC680_04025	COG3040	lipid binding
HC680_04035	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC680_04040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC680_04045	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC680_04050	COG1538	Outer membrane efflux protein
HC680_04055	COG0745	RESPONSE REGULATOR receiver
HC680_04060	COG5002	protein histidine kinase activity
HC680_04075	COG2850	peptidyl-arginine hydroxylation
HC680_04105	COG0842	Transport permease protein
HC680_04110	COG0842	Transport permease protein
HC680_04110	COG1129	ABC transporter
HC680_04115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC680_04125	COG1879	ABC-type sugar transport system periplasmic component
HC680_04130	COG1129	ABC transporter
HC680_04135	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC680_04145	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC680_04160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC680_04165	COG5457	Domain of unknown function (DUF1127)
HC680_04175	COG1566	PFAM secretion protein HlyD family protein
HC680_04190	COG1924	4 iron, 4 sulfur cluster binding
HC680_04195	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HC680_04210	COG2733	membrane
HC680_04220	COG2207	Transcriptional regulator
HC680_04220	COG1917	Cupin 2, conserved barrel domain protein
HC680_04225	COG5464	transposase or invertase
HC680_04230	COG1012	belongs to the aldehyde dehydrogenase family
HC680_04240	COG0523	cobalamin synthesis protein
HC680_04245	COG2879	small protein
HC680_04250	COG1966	Carbon starvation protein
HC680_04265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC680_04270	COG2368	4-hydroxyphenylacetate
HC680_04290	COG3971	2-oxopent-4-enoate hydratase activity
HC680_04300	COG3384	dioxygenase
HC680_04305	COG1012	belongs to the aldehyde dehydrogenase family
HC680_04315	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC680_04325	COG1846	Transcriptional regulator
HC680_04355	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HC680_04370	COG3734	2-keto-3-deoxy-galactonokinase
HC680_04375	COG0800	Aldolase
HC680_04380	COG1737	Transcriptional regulator
HC680_04390	COG1214	PFAM Peptidase M22, glycoprotease
HC680_04390	COG0456	acetyltransferase
HC680_04395	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC680_04395	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HC680_04410	COG3715	PTS system
HC680_04415	COG3716	PTS system mannose fructose sorbose family IID component
HC680_04420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC680_04430	COG5464	transposase or invertase
HC680_04445	COG1484	DNA-dependent DNA replication
HC680_04460	COG2966	Psort location CytoplasmicMembrane, score
HC680_04475	COG2197	response regulator
HC680_04480	COG2197	response regulator
HC680_04485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC680_04490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC680_04490	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC680_04495	COG4114	ferric iron reductase
HC680_04500	COG3706	GGDEF domain
HC680_04535	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HC680_04540	COG0456	acetyltransferase
HC680_04545	COG1011	Hydrolase
HC680_04555	COG2823	Periplasmic or secreted lipoprotein
HC680_04565	COG4667	esterase of the alpha-beta hydrolase superfamily
HC680_04570	COG0084	hydrolase, TatD family'
HC680_04575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC680_04605	COG3726	membrane protein affecting hemolysin expression
HC680_04610	COG0560	Phosphoserine phosphatase
HC680_04615	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HC680_04625	COG0488	(ABC) transporter
HC680_04630	COG0741	lytic transglycosylase activity
HC680_04650	COG2207	Transcriptional regulator
HC680_04650	COG3708	Transcriptional regulator
HC680_04655	COG3045	CreA protein
HC680_04660	COG0745	RESPONSE REGULATOR receiver
HC680_04665	COG2205	protein histidine kinase activity
HC680_04670	COG4452	Inner membrane protein CreD
HC680_04675	COG0745	RESPONSE REGULATOR receiver
HC680_04685	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HC680_04700	COG0460	homoserine dehydrogenase
HC680_04700	COG0527	aspartate kinase activity
HC680_04710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HC680_04725	COG1115	amino acid carrier protein
HC680_04730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC680_04735	COG0521	Mo-molybdopterin cofactor biosynthetic process
HC680_04740	COG0477	Major facilitator Superfamily
HC680_04745	COG1584	GPR1 FUN34 yaaH family protein
HC680_04750	COG4735	regulation of single-species biofilm formation
HC680_04775	COG0583	DNA-binding transcription factor activity
HC680_04795	COG0196	riboflavin kinase activity
HC680_04810	COG1047	Peptidyl-prolyl cis-trans
HC680_04835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HC680_04850	COG0505	Belongs to the CarA family
HC680_04895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HC680_04905	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HC680_04910	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HC680_04925	COG3493	citrate carrier protein
HC680_04935	COG0564	pseudouridine synthase activity
HC680_04945	COG0417	DNA replication proofreading
HC680_04950	COG0235	Class ii aldolase
HC680_04975	COG0586	Pfam SNARE associated Golgi protein
HC680_04985	COG1178	ABC-type Fe3 transport system permease component
HC680_05010	COG2814	Major facilitator Superfamily
HC680_05015	COG2271	Major facilitator Superfamily
HC680_05020	COG0583	DNA-binding transcription factor activity
HC680_05030	COG0738	Major facilitator superfamily
HC680_05080	COG0028	Belongs to the TPP enzyme family
HC680_05090	COG1609	Transcriptional regulator
HC680_05110	COG0768	penicillin binding
HC680_05115	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HC680_05120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HC680_05135	COG0772	Belongs to the SEDS family
HC680_05160	COG0849	cell division
HC680_05165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HC680_05185	COG0494	nUDIX hydrolase
HC680_05210	COG1459	type II secretion system
HC680_05215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HC680_05220	COG4969	Belongs to the N-Me-Phe pilin family
HC680_05230	COG3023	N-Acetylmuramoyl-L-alanine amidase
HC680_05235	COG3725	Membrane protein required for beta-lactamase induction
HC680_05240	COG3940	Belongs to the glycosyl hydrolase 43 family
HC680_05245	COG2211	Major facilitator Superfamily
HC680_05250	COG1113	amino acid transport
HC680_05255	COG2186	Transcriptional regulator
HC680_05260	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HC680_05265	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC680_05270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC680_05285	COG3064	Membrane
HC680_05335	COG2132	Multicopper oxidase
HC680_05340	COG4993	Dehydrogenase
HC680_05355	COG0288	reversible hydration of carbon dioxide
HC680_05360	COG1131	(ABC) transporter
HC680_05365	COG0842	Transport permease protein
HC680_05370	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_05375	COG0726	polysaccharide deacetylase
HC680_05395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HC680_05400	COG0617	tRNA 3'-terminal CCA addition
HC680_05420	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC680_05425	COG1643	Atp-dependent helicase
HC680_05525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC680_05530	COG4774	siderophore transport
HC680_05535	COG1120	ATPase activity
HC680_05540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC680_05545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC680_05565	COG2860	membrane
HC680_05585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC680_05590	COG3835	regulator
HC680_05605	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HC680_05610	COG0024	Methionine aminopeptidase
HC680_05635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HC680_05645	COG0575	Belongs to the CDS family
HC680_05650	COG0750	zinc metalloprotease
HC680_05660	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HC680_05705	COG0346	lactoylglutathione lyase activity
HC680_05715	COG4568	rho-dependent transcription termination
HC680_05730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HC680_05735	COG3015	lipoprotein NlpE involved in copper resistance
HC680_05740	COG0791	NLP P60 protein
HC680_05750	COG1720	tRNA m6t6A37 methyltransferase activity
HC680_05760	COG1464	Belongs to the NlpA lipoprotein family
HC680_05765	COG2011	ABC-type metal ion transport system permease component
HC680_05775	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HC680_05810	COG0656	L-ascorbic acid biosynthetic process
HC680_05815	COG0583	DNA-binding transcription factor activity
HC680_05820	COG2814	Major facilitator Superfamily
HC680_05830	COG2226	methyltransferase
HC680_05835	COG0741	lytic transglycosylase activity
HC680_05835	COG1388	LysM domain
HC680_05845	COG2226	methyltransferase
HC680_05855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC680_05865	COG0583	DNA-binding transcription factor activity
HC680_05875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC680_05880	COG1960	acyl-CoA dehydrogenase activity
HC680_05890	COG0121	glutamine amidotransferase
HC680_05895	COG3034	peptidoglycan biosynthetic process
HC680_05910	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HC680_05915	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HC680_05930	COG2991	Protein conserved in bacteria
HC680_05945	COG0454	-acetyltransferase
HC680_05950	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC680_05970	COG1802	Transcriptional regulator
HC680_05975	COG1113	amino acid transport
HC680_05980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC680_05985	COG1012	belongs to the aldehyde dehydrogenase family
HC680_05990	COG0579	oxidoreductase
HC680_06005	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HC680_06010	COG0625	glutathione transferase activity
HC680_06015	COG3775	system Galactitol-specific IIC component
HC680_06020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC680_06025	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_06030	COG1070	Carbohydrate kinase
HC680_06050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC680_06055	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC680_06060	COG0022	dehydrogenase e1 component
HC680_06065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC680_06070	COG2909	trisaccharide binding
HC680_06075	COG0511	ligase activity, forming carbon-carbon bonds
HC680_06080	COG0439	Biotin carboxylase
HC680_06085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC680_06090	COG0697	spore germination
HC680_06105	COG1984	allophanate hydrolase subunit 2
HC680_06110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HC680_06115	COG0436	Aminotransferase
HC680_06130	COG4221	oxidoreductase activity
HC680_06140	COG0765	amino acid transport
HC680_06170	COG0791	NLP P60 protein
HC680_06185	COG3639	organic phosphonate transmembrane transporter activity
HC680_06195	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HC680_06220	COG3188	usher protein
HC680_06235	COG0765	amino acid transport
HC680_06240	COG4597	amino acid ABC transporter
HC680_06245	COG1126	abc transporter atp-binding protein
HC680_06250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC680_06290	COG4302	ethanolamine ammonia-lyase activity
HC680_06295	COG4303	Ethanolamine ammonia lyase large subunit
HC680_06310	COG0833	amino acid
HC680_06315	COG2040	homocysteine
HC680_06320	COG4521	taurine ABC transporter
HC680_06325	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HC680_06330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC680_06335	COG2175	clavaminate synthase activity
HC680_06345	COG0113	porphobilinogen synthase activity
HC680_06350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC680_06355	COG1335	isochorismatase
HC680_06360	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HC680_06400	COG1785	Belongs to the alkaline phosphatase family
HC680_06410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC680_06420	COG3416	Protein conserved in bacteria
HC680_06425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC680_06435	COG4126	flavin adenine dinucleotide binding
HC680_06450	COG1940	carbohydrate kinase activity
HC680_06455	COG0419	ATPase involved in DNA repair
HC680_06460	COG0420	3'-5' exonuclease activity
HC680_06485	COG0366	Alpha amylase catalytic
HC680_06490	COG0583	DNA-binding transcription factor activity
HC680_06495	COG1335	isochorismatase
HC680_06505	COG1228	amidohydrolase
HC680_06515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC680_06530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_06535	COG0450	alkyl hydroperoxide reductase
HC680_06560	COG1862	Preprotein translocase
HC680_06565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC680_06570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC680_06590	COG4238	major outer membrane lipoprotein
HC680_06600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC680_06600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC680_06620	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC680_06625	COG0667	Aldo Keto reductase
HC680_06635	COG0142	geranyltranstransferase activity
HC680_06660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC680_06670	COG2814	Major facilitator Superfamily
HC680_06675	COG0673	inositol 2-dehydrogenase activity
HC680_06690	COG1053	succinate dehydrogenase
HC680_06700	COG1053	succinate dehydrogenase
HC680_06705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC680_06710	COG1414	Transcriptional regulator
HC680_06725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HC680_06730	COG1845	cytochrome c oxidase, subunit III
HC680_06735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC680_06740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC680_06745	COG2223	nitrite transmembrane transporter activity
HC680_06750	COG3056	Lipoprotein
HC680_06755	COG0271	Belongs to the BolA IbaG family
HC680_06780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HC680_06785	COG0776	regulation of translation
HC680_06790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC680_06795	COG1555	photosystem II stabilization
HC680_06800	COG0824	Thioesterase
HC680_06810	COG4533	DNA binding
HC680_06825	COG1522	sequence-specific DNA binding
HC680_06830	COG1132	(ABC) transporter
HC680_06835	COG1132	(ABC) transporter
HC680_06840	COG0347	Belongs to the P(II) protein family
HC680_06845	COG0004	ammonium transporteR
HC680_06850	COG1946	Acyl-CoA thioesterase
HC680_06855	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HC680_06860	COG3695	enzyme binding
HC680_06890	COG2364	Membrane
HC680_06905	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HC680_06920	COG2182	Extracellular solute-binding protein
HC680_06925	COG1175	transmembrane transport
HC680_06930	COG3833	ABC-type maltose transport systems, permease component
HC680_06935	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HC680_06940	COG1874	Beta-galactosidase
HC680_06985	COG0110	maltose O-acetyltransferase activity
HC680_07000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC680_07005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC680_07010	COG1309	transcriptional regulator
HC680_07015	COG3264	Mechanosensitive ion channel
HC680_07015	COG1196	nuclear chromosome segregation
HC680_07020	COG5464	transposase or invertase
HC680_07030	COG3923	Primosomal replication protein n
HC680_07035	COG2832	Protein of unknown function (DUF454)
HC680_07075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC680_07080	COG4651	solute:proton antiporter activity
HC680_07080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HC680_07095	COG2223	nitrite transmembrane transporter activity
HC680_07105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC680_07110	COG3735	TraB family
HC680_07125	COG1585	Membrane protein implicated in regulation of membrane protease activity
HC680_07130	COG0330	HflC and HflK could
HC680_07135	COG4619	ABC transporter
HC680_07140	COG0390	transport system, permease component
HC680_07145	COG3118	belongs to the thioredoxin family
HC680_07150	COG0300	oxidoreductase activity
HC680_07155	COG2755	lipolytic protein G-D-S-L family
HC680_07160	COG4181	ATPase activity
HC680_07165	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HC680_07185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HC680_07190	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HC680_07205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HC680_07215	COG2501	S4 domain
HC680_07390	COG3772	lysozyme
HC680_07545	COG0582	viral genome integration into host DNA
HC680_07680	COG3539	Fimbrial protein
HC680_07685	COG3121	Chaperone
HC680_07690	COG3188	usher protein
HC680_07705	COG1560	Kdo2-lipid A biosynthetic process
HC680_07715	COG3710	Transcriptional regulator
HC680_07720	COG0531	amino acid
HC680_07725	COG1982	Orn Lys Arg decarboxylase major
HC680_07730	COG3104	oligopeptide transport
HC680_07760	COG0673	inositol 2-dehydrogenase activity
HC680_07775	COG1129	ABC transporter
HC680_07780	COG4211	Belongs to the binding-protein-dependent transport system permease family
HC680_07835	COG1566	PFAM secretion protein HlyD family protein
HC680_07840	COG1120	ATPase activity
HC680_07845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC680_07880	COG1473	amidohydrolase
HC680_07885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC680_07890	COG0667	Aldo Keto reductase
HC680_07895	COG4608	Belongs to the ABC transporter superfamily
HC680_07900	COG0444	Belongs to the ABC transporter superfamily
HC680_07905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC680_07910	COG0601	transmembrane transport
HC680_07915	COG0747	negative chemotaxis
HC680_07940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC680_07950	COG0668	transmembrane transport
HC680_07955	COG0583	DNA-binding transcription factor activity
HC680_07970	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_07980	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC680_07985	COG1129	ABC transporter
HC680_07995	COG1879	ABC-type sugar transport system periplasmic component
HC680_08000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC680_08005	COG2390	Transcriptional regulator
HC680_08010	COG3959	Transketolase, thiamine diphosphate binding domain
HC680_08015	COG3958	Transketolase
HC680_08020	COG2977	Belongs to the P-Pant transferase superfamily
HC680_08025	COG4771	TonB-dependent receptor
HC680_08030	COG2382	esterase
HC680_08035	COG3251	PFAM MbtH domain protein
HC680_08040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC680_08040	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HC680_08045	COG1120	ATPase activity
HC680_08050	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC680_08055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC680_08065	COG4592	Periplasmic binding protein
HC680_08070	COG1169	isochorismate synthase
HC680_08075	COG1021	2,3-dihydroxybenzoate-AMP ligase
HC680_08080	COG1535	isochorismatase
HC680_08080	COG3433	isochorismatase activity
HC680_08085	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_08095	COG1966	Carbon starvation protein
HC680_08100	COG2879	small protein
HC680_08115	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_08120	COG0371	Dehydrogenase
HC680_08125	COG1129	ABC transporter
HC680_08130	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC680_08165	COG2271	Major facilitator Superfamily
HC680_08170	COG0483	inositol monophosphate 1-phosphatase activity
HC680_08180	COG0402	S-adenosylhomocysteine deaminase activity
HC680_08190	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC680_08205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC680_08215	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC680_08220	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC680_08225	COG1129	ABC transporter
HC680_08250	COG0436	Aminotransferase
HC680_08255	COG1475	DNA binding
HC680_08260	COG3969	phosphoadenosine phosphosulfate
HC680_08265	COG0583	DNA-binding transcription factor activity
HC680_08270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HC680_08290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC680_08295	COG3719	Belongs to the RNase T2 family
HC680_08300	COG3069	C4-dicarboxylate transmembrane transporter activity
HC680_08320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC680_08335	COG0583	DNA-binding transcription factor activity
HC680_08350	COG1686	Belongs to the peptidase S11 family
HC680_08355	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HC680_08360	COG0772	Belongs to the SEDS family
HC680_08365	COG0768	penicillin binding
HC680_08375	COG0799	negative regulation of ribosome biogenesis
HC680_08390	COG1466	dna polymerase III delta subunit
HC680_08405	COG2888	peptidyl-tyrosine sulfation
HC680_08420	COG1126	abc transporter atp-binding protein
HC680_08425	COG0765	amino acid transport
HC680_08430	COG0765	amino acid transport
HC680_08455	COG1702	phosphate starvation-inducible protein PhoH
HC680_08465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC680_08505	COG0367	asparagine synthase
HC680_08510	COG0647	UMP catabolic process
HC680_08515	COG1940	carbohydrate kinase activity
HC680_08515	COG1846	Transcriptional regulator
HC680_08520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HC680_08560	COG0735	belongs to the Fur family
HC680_08575	COG0596	Alpha beta hydrolase
HC680_08585	COG0033	Phosphoglucomutase
HC680_08595	COG0745	RESPONSE REGULATOR receiver
HC680_08600	COG2205	protein histidine kinase activity
HC680_08630	COG0415	Belongs to the DNA photolyase family
HC680_08645	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HC680_08650	COG1984	allophanate hydrolase subunit 2
HC680_08685	COG2009	succinate dehydrogenase
HC680_08690	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HC680_08695	COG1053	succinate dehydrogenase
HC680_08700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HC680_08705	COG0567	Dehydrogenase, E1 component
HC680_08710	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC680_08720	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HC680_08730	COG1271	oxidase subunit
HC680_08735	COG1294	oxidase, subunit
HC680_08740	COG4890	Cyd operon protein YbgT
HC680_08745	COG3790	cyd operon protein YbgE
HC680_08750	COG0824	Thioesterase
HC680_08755	COG0811	peptide transport
HC680_08760	COG0848	biopolymer transport protein
HC680_08765	COG3064	Membrane
HC680_08775	COG2885	chlorophyll binding
HC680_08780	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HC680_08830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HC680_08835	COG3201	nicotinamide mononucleotide transporter
HC680_08850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HC680_08860	COG2017	converts alpha-aldose to the beta-anomer
HC680_08870	COG1085	galactose-1-phosphate uridylyltransferase
HC680_08885	COG1119	ATPase activity
HC680_08895	COG3585	molybdate ion transport
HC680_08895	COG2005	Transcriptional regulator
HC680_08905	COG0725	ABC transporter, periplasmic molybdate-binding protein
HC680_08910	COG4149	molybdate abc transporter
HC680_08920	COG0561	phosphatase activity
HC680_08945	COG2200	EAL domain
HC680_08950	COG0789	Transcriptional regulator
HC680_08985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC680_08990	COG0589	response to stress
HC680_09000	COG4677	pectinesterase activity
HC680_09045	COG2223	nitrite transmembrane transporter activity
HC680_09055	COG2133	pyrroloquinoline quinone binding
HC680_09060	COG0625	glutathione transferase activity
HC680_09070	COG1686	Belongs to the peptidase S11 family
HC680_09075	COG1349	DNA-binding transcription factor activity
HC680_09080	COG0671	phosphoesterase, PA-phosphatase related
HC680_09085	COG2814	Major facilitator Superfamily
HC680_09090	COG0561	phosphatase activity
HC680_09095	COG0738	Major facilitator superfamily
HC680_09100	COG3226	Transcriptional regulator
HC680_09125	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HC680_09175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC680_09185	COG3344	reverse transcriptase
HC680_09195	COG4695	Portal protein
HC680_09285	COG3039	Transposase
HC680_09375	COG0778	Nitroreductase
HC680_09390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HC680_09395	COG3842	ATPase activity
HC680_09400	COG1176	ABC-type spermidine putrescine transport system, permease component I
HC680_09405	COG1177	transmembrane transport
HC680_09420	COG0745	RESPONSE REGULATOR receiver
HC680_09425	COG5002	protein histidine kinase activity
HC680_09430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC680_09435	COG4160	amino acid transport
HC680_09440	COG4215	(ABC) transporter
HC680_09445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC680_09450	COG1126	abc transporter atp-binding protein
HC680_09460	COG5001	Diguanylate cyclase
HC680_09460	COG4251	negative regulation of phosphorylation
HC680_09460	COG3706	GGDEF domain
HC680_09460	COG2203	Gaf domain
HC680_09465	COG3023	N-Acetylmuramoyl-L-alanine amidase
HC680_09470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC680_09475	COG0702	epimerase
HC680_09480	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HC680_09485	COG0028	Belongs to the TPP enzyme family
HC680_09495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC680_09505	COG2431	L-lysine efflux transmembrane transporter activity
HC680_09515	COG3593	DNA synthesis involved in DNA repair
HC680_09520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC680_09530	COG1278	Cold shock
HC680_09540	COG0542	response to heat
HC680_09555	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HC680_09560	COG4988	ABC transporter
HC680_09565	COG0492	ferredoxin-NADP+ reductase activity
HC680_09580	COG1178	ABC-type Fe3 transport system permease component
HC680_09580	COG1674	ftsk spoiiie
HC680_09590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HC680_09600	COG0243	molybdopterin cofactor binding
HC680_09605	COG0437	4 iron, 4 sulfur cluster binding
HC680_09610	COG3302	dmso reductase anchor subunit
HC680_09620	COG0477	Major facilitator Superfamily
HC680_09625	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HC680_09630	COG1882	Formate acetyltransferase
HC680_09635	COG2116	formate transmembrane transporter activity
HC680_09640	COG1944	ATP diphosphatase activity
HC680_09645	COG2323	membrane
HC680_09665	COG0539	negative regulation of cytoplasmic translation
HC680_09675	COG2333	competence protein COMEC
HC680_09675	COG0658	competence protein
HC680_09690	COG3214	Protein conserved in bacteria
HC680_09705	COG3173	Aminoglycoside phosphotransferase
HC680_09710	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HC680_09715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HC680_09725	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HC680_09735	COG2989	Protein conserved in bacteria
HC680_09740	COG3108	Peptidase M15
HC680_09745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC680_09750	COG1448	Aminotransferase
HC680_09755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HC680_09775	COG0814	amino acid
HC680_09785	COG1473	amidohydrolase
HC680_09795	COG0308	aminopeptidase N
HC680_09805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC680_09810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC680_09815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC680_09820	COG0431	NADPH-dependent FMN reductase
HC680_09835	COG3217	Mosc domain protein beta barrel domain protein
HC680_09835	COG0633	Ferredoxin
HC680_09845	COG0488	(ABC) transporter
HC680_09850	COG2995	paraquat-inducible protein a
HC680_09855	COG3008	intermembrane lipid transfer
HC680_09855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HC680_09860	COG3009	Protein conserved in bacteria
HC680_09865	COG3130	regulation of translation
HC680_09875	COG1067	ATP-dependent peptidase activity
HC680_09895	COG3070	regulator of competence-specific genes
HC680_09900	COG1289	transmembrane transporter activity
HC680_09905	COG3304	Inner membrane component domain
HC680_09910	COG0210	DNA helicase
HC680_09920	COG1832	CoA-binding protein
HC680_09935	COG1881	PFAM PEBP family protein
HC680_09940	COG2207	Transcriptional regulator
HC680_09955	COG0670	Belongs to the BI1 family
HC680_09980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC680_09985	COG1012	belongs to the aldehyde dehydrogenase family
HC680_09990	COG4638	Rieske (2fe-2S)
HC680_09995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC680_10000	COG0473	3-isopropylmalate dehydrogenase activity
HC680_10005	COG0583	DNA-binding transcription factor activity
HC680_10010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC680_10015	COG1012	belongs to the aldehyde dehydrogenase family
HC680_10020	COG1396	sequence-specific DNA binding
HC680_10020	COG1917	Cupin 2, conserved barrel domain protein
HC680_10025	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HC680_10030	COG0174	glutamine synthetase
HC680_10035	COG0531	amino acid
HC680_10050	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_10080	COG3729	General stress protein
HC680_10090	COG2233	PERMEase
HC680_10125	COG1309	transcriptional regulator
HC680_10140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC680_10155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC680_10175	COG1702	phosphate starvation-inducible protein PhoH
HC680_10180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HC680_10190	COG1335	isochorismatase
HC680_10200	COG0583	DNA-binding transcription factor activity
HC680_10205	COG1309	transcriptional regulator
HC680_10230	COG3381	protein complex oligomerization
HC680_10265	COG5645	(Lipo)protein
HC680_10280	COG1560	Kdo2-lipid A biosynthetic process
HC680_10330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC680_10350	COG2814	Major facilitator Superfamily
HC680_10355	COG0583	DNA-binding transcription factor activity
HC680_10360	COG1530	ribonuclease E activity
HC680_10380	COG1399	metal-binding, possibly nucleic acid-binding protein
HC680_10400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC680_10415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC680_10420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC680_10425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC680_10435	COG0470	DNA polymerase III
HC680_10440	COG0084	hydrolase, TatD family'
HC680_10450	COG0537	adenosine 5'-monophosphoramidase activity
HC680_10455	COG5633	Lipoprotein
HC680_10480	COG1252	NADH dehydrogenase
HC680_10485	COG3134	Outer membrane lipoprotein
HC680_10500	COG1309	transcriptional regulator
HC680_10515	COG1388	LysM domain
HC680_10515	COG1376	ErfK ybiS ycfS ynhG family protein
HC680_10520	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HC680_10530	COG4591	ABC-type transport system involved in lipoprotein release permease component
HC680_10540	COG4591	ABC-type transport system involved in lipoprotein release permease component
HC680_10550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HC680_10560	COG2390	Transcriptional regulator
HC680_10575	COG3395	kinase activity
HC680_10590	COG0698	ribose 5-phosphate isomerase
HC680_10595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC680_10600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HC680_10605	COG0318	PFAM AMP-dependent synthetase and ligase
HC680_10620	COG1177	transmembrane transport
HC680_10640	COG1943	Transposase
HC680_10645	COG1943	Transposase
HC680_10650	COG2850	peptidyl-arginine hydroxylation
HC680_10655	COG2205	protein histidine kinase activity
HC680_10675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HC680_10695	COG1187	pseudouridine synthase activity
HC680_10700	COG0538	isocitrate dehydrogenase activity
HC680_10705	COG0582	viral genome integration into host DNA
HC680_10720	COG3706	GGDEF domain
HC680_10725	COG3300	MHYT domain
HC680_10725	COG5001	Diguanylate cyclase
HC680_10730	COG0538	isocitrate dehydrogenase activity
HC680_10735	COG0640	Transcriptional regulator
HC680_10760	COG3813	Protein conserved in bacteria
HC680_10765	COG1063	alcohol dehydrogenase
HC680_10770	COG3729	General stress protein
HC680_10775	COG3685	Protein conserved in bacteria
HC680_10780	COG3685	Protein conserved in bacteria
HC680_10785	COG3546	catalase activity
HC680_10790	COG1271	oxidase subunit
HC680_10795	COG1294	oxidase, subunit
HC680_10825	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HC680_10830	COG0583	DNA-binding transcription factor activity
HC680_10835	COG3706	GGDEF domain
HC680_10840	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HC680_10855	COG1560	Kdo2-lipid A biosynthetic process
HC680_10865	COG3182	Iron-regulated membrane protein
HC680_10885	COG2203	Gaf domain
HC680_10885	COG2199	diguanylate cyclase activity
HC680_10890	COG3042	response to heat
HC680_10895	COG3189	MarR family transcriptional regulator
HC680_10900	COG1683	Conserved Protein
HC680_10905	COG0504	CTP synthase activity
HC680_10910	COG2807	transmembrane transport
HC680_10915	COG2207	Transcriptional regulator
HC680_10925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC680_10930	COG0859	PFAM glycosyl transferase family 9
HC680_10940	COG3344	reverse transcriptase
HC680_10945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC680_10950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC680_10955	COG0583	DNA-binding transcription factor activity
HC680_10960	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_10985	COG0386	Belongs to the glutathione peroxidase family
HC680_11000	COG2766	serine protein kinase
HC680_11005	COG3713	MltA-interacting MipA family protein
HC680_11010	COG0656	L-ascorbic acid biosynthetic process
HC680_11030	COG3139	Protein of unknown function (DUF1315)
HC680_11045	COG1335	isochorismatase
HC680_11050	COG0252	asparaginase activity
HC680_11055	COG0616	signal peptide processing
HC680_11060	COG0778	Nitroreductase
HC680_11070	COG0709	Synthesizes selenophosphate from selenide and ATP
HC680_11075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC680_11080	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_11080	COG0604	alcohol dehydrogenase
HC680_11080	COG3321	synthase
HC680_11085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC680_11090	COG0494	nUDIX hydrolase
HC680_11095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HC680_11100	COG2897	thiosulfate sulfurtransferase activity
HC680_11105	COG4136	ATPase activity
HC680_11110	COG4135	transport system, permease component
HC680_11115	COG4134	Bacterial extracellular solute-binding protein
HC680_11120	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC680_11125	COG0398	Pfam SNARE associated Golgi protein
HC680_11130	COG0398	Pfam SNARE associated Golgi protein
HC680_11135	COG0708	Exodeoxyribonuclease III
HC680_11145	COG3138	arginine N-succinyltransferase
HC680_11155	COG3724	N-succinylarginine dihydrolase activity
HC680_11165	COG3678	ATP-independent chaperone mediated protein folding
HC680_11170	COG0322	excinuclease ABC activity
HC680_11180	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC680_11185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC680_11195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC680_11200	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC680_11205	COG2169	Transcriptional regulator
HC680_11205	COG1917	Cupin 2, conserved barrel domain protein
HC680_11210	COG1486	melibiose metabolic process
HC680_11220	COG0753	catalase activity
HC680_11235	COG1988	membrane-bound metal-dependent
HC680_11240	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_11245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC680_11275	COG0727	PFAM Uncharacterised protein family (UPF0153)
HC680_11280	COG3047	cAMP biosynthetic process
HC680_11290	COG4774	siderophore transport
HC680_11325	COG0134	indole-3-glycerol-phosphate synthase activity
HC680_11325	COG0135	phosphoribosylanthranilate isomerase activity
HC680_11330	COG0512	Glutamine amidotransferase of anthranilate synthase
HC680_11330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HC680_11335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC680_11345	COG0009	L-threonylcarbamoyladenylate synthase
HC680_11355	COG0583	DNA-binding transcription factor activity
HC680_11365	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HC680_11370	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_11380	COG0616	signal peptide processing
HC680_11405	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HC680_11415	COG0671	phosphoesterase, PA-phosphatase related
HC680_11420	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HC680_11425	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HC680_11435	COG0023	Translation Initiation Factor
HC680_11450	COG1349	DNA-binding transcription factor activity
HC680_11465	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC680_11465	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC680_11470	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HC680_11480	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC680_11495	COG4171	peptide transport system, permease
HC680_11510	COG0702	epimerase
HC680_11525	COG1473	amidohydrolase
HC680_11535	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC680_11540	COG1842	Phage shock protein A
HC680_11550	COG1983	PspC domain protein
HC680_11560	COG3106	COG3106 Predicted ATPase
HC680_11570	COG0583	DNA-binding transcription factor activity
HC680_11575	COG1486	melibiose metabolic process
HC680_11585	COG3180	Ammonia monooxygenase
HC680_11590	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HC680_11595	COG4948	Mandelate Racemase Muconate Lactonizing
HC680_11600	COG2866	Carboxypeptidase
HC680_11610	COG4166	transmembrane transport
HC680_11635	COG0656	L-ascorbic acid biosynthetic process
HC680_11655	COG0583	DNA-binding transcription factor activity
HC680_11660	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_11665	COG1078	dGTPase activity
HC680_11670	COG0693	protein deglycase activity
HC680_11700	COG2885	chlorophyll binding
HC680_11825	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_11830	COG1309	transcriptional regulator
HC680_11835	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_11855	COG0583	DNA-binding transcription factor activity
HC680_11890	COG0436	Aminotransferase
HC680_11905	COG2011	ABC-type metal ion transport system permease component
HC680_11910	COG1448	Aminotransferase
HC680_11920	COG1522	sequence-specific DNA binding
HC680_11925	COG1113	amino acid transport
HC680_11940	COG0673	inositol 2-dehydrogenase activity
HC680_11945	COG1349	DNA-binding transcription factor activity
HC680_11955	COG0513	Belongs to the DEAD box helicase family
HC680_11965	COG0589	response to stress
HC680_11975	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HC680_11980	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HC680_11980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC680_11980	COG0674	pyruvate-flavodoxin oxidoreductase activity
HC680_11980	COG1013	pyruvate-flavodoxin oxidoreductase activity
HC680_11985	COG3042	response to heat
HC680_11990	COG3187	Heat shock protein
HC680_11995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC680_12000	COG0586	Pfam SNARE associated Golgi protein
HC680_12005	COG2911	Protein conserved in bacteria
HC680_12015	COG3784	Protein of unknown function (DUF1318)
HC680_12020	COG2207	Transcriptional regulator
HC680_12025	COG1012	belongs to the aldehyde dehydrogenase family
HC680_12040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC680_12050	COG1126	abc transporter atp-binding protein
HC680_12055	COG0583	DNA-binding transcription factor activity
HC680_12060	COG2072	flavoprotein involved in K transport
HC680_12075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC680_12095	COG2030	dehydratase
HC680_12095	COG1012	belongs to the aldehyde dehydrogenase family
HC680_12100	COG3396	Phenylacetate-CoA oxygenase
HC680_12105	COG3460	Phenylacetate-CoA oxygenase
HC680_12110	COG3396	Phenylacetate-CoA oxygenase
HC680_12115	COG2151	metal-sulfur cluster biosynthetic enzyme
HC680_12120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC680_12125	COG1024	Enoyl-CoA hydratase
HC680_12130	COG1024	Enoyl-CoA hydratase
HC680_12135	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC680_12140	COG2050	protein possibly involved in aromatic compounds catabolism
HC680_12145	COG0183	Belongs to the thiolase family
HC680_12150	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HC680_12155	COG3327	negative regulation of DNA-templated transcription, initiation
HC680_12160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HC680_12175	COG1643	Atp-dependent helicase
HC680_12180	COG4122	O-methyltransferase activity
HC680_12205	COG0583	DNA-binding transcription factor activity
HC680_12210	COG0667	Aldo Keto reductase
HC680_12215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC680_12225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC680_12230	COG3138	arginine N-succinyltransferase
HC680_12235	COG1012	belongs to the aldehyde dehydrogenase family
HC680_12240	COG3724	N-succinylarginine dihydrolase activity
HC680_12245	COG2988	succinylglutamate desuccinylase activity
HC680_12250	COG1113	amino acid transport
HC680_12255	COG0477	Major facilitator Superfamily
HC680_12260	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HC680_12270	COG1012	belongs to the aldehyde dehydrogenase family
HC680_12275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC680_12280	COG0401	homolog of Blt101
HC680_12285	COG5562	phage envelope protein
HC680_12290	COG0425	Belongs to the sulfur carrier protein TusA family
HC680_12320	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HC680_12325	COG1263	PTS System
HC680_12325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC680_12330	COG1609	Transcriptional regulator
HC680_12335	COG5339	Protein conserved in bacteria
HC680_12340	COG1482	cell wall glycoprotein biosynthetic process
HC680_12345	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HC680_12345	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HC680_12350	COG0114	fumarate hydratase activity
HC680_12360	COG2205	protein histidine kinase activity
HC680_12370	COG0745	RESPONSE REGULATOR receiver
HC680_12375	COG3136	membrane protein required for alginate biosynthesis
HC680_12385	COG0531	amino acid
HC680_12405	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HC680_12410	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HC680_12425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC680_12440	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HC680_12445	COG1473	amidohydrolase
HC680_12455	COG0583	DNA-binding transcription factor activity
HC680_12460	COG2840	Smr protein MutS2
HC680_12465	COG1414	Transcriptional regulator
HC680_12475	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC680_12480	COG0183	Belongs to the thiolase family
HC680_12490	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HC680_12495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC680_12505	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HC680_12505	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HC680_12525	COG4565	transcriptional regulatory protein
HC680_12530	COG3290	protein histidine kinase activity
HC680_12555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC680_12595	COG0628	permease
HC680_12615	COG3591	Belongs to the peptidase S1B family
HC680_12635	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HC680_12640	COG2814	Major facilitator Superfamily
HC680_12645	COG0583	DNA-binding transcription factor activity
HC680_12650	COG1940	carbohydrate kinase activity
HC680_12655	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HC680_12670	COG3302	dmso reductase anchor subunit
HC680_12675	COG0437	4 iron, 4 sulfur cluster binding
HC680_12680	COG0243	molybdopterin cofactor binding
HC680_12695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC680_12710	COG2271	Major facilitator Superfamily
HC680_12715	COG0246	Mannitol dehydrogenase
HC680_12720	COG0589	response to stress
HC680_12725	COG1802	Transcriptional regulator
HC680_12730	COG4221	oxidoreductase activity
HC680_12745	COG2207	Transcriptional regulator
HC680_12750	COG2135	peptidase activity
HC680_12765	COG2197	response regulator
HC680_12785	COG0071	Belongs to the small heat shock protein (HSP20) family
HC680_12790	COG1546	Belongs to the CinA family
HC680_12795	COG2200	EAL domain
HC680_12810	COG3708	Transcriptional regulator
HC680_12810	COG2207	Transcriptional regulator
HC680_12815	COG2610	gluconate transmembrane transporter activity
HC680_12820	COG3622	Belongs to the hyi family
HC680_12825	COG0235	Class ii aldolase
HC680_12835	COG2084	Dehydrogenase
HC680_12840	COG1349	DNA-binding transcription factor activity
HC680_12855	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HC680_12860	COG2223	nitrite transmembrane transporter activity
HC680_12900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC680_12905	COG0683	leucine binding
HC680_12920	COG1129	ABC transporter
HC680_12935	COG2814	Major facilitator Superfamily
HC680_12940	COG0697	spore germination
HC680_12950	COG4977	sequence-specific DNA binding
HC680_12980	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_12985	COG2731	YhcH YjgK YiaL family protein
HC680_13000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC680_13010	COG3395	kinase activity
HC680_13015	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HC680_13020	COG1349	DNA-binding transcription factor activity
HC680_13025	COG0039	L-malate dehydrogenase activity
HC680_13035	COG0583	DNA-binding transcription factor activity
HC680_13040	COG1012	belongs to the aldehyde dehydrogenase family
HC680_13055	COG2199	diguanylate cyclase activity
HC680_13125	COG0477	Major facilitator Superfamily
HC680_13140	COG2070	2-Nitropropane dioxygenase
HC680_13145	COG2011	ABC-type metal ion transport system permease component
HC680_13165	COG4628	conserved protein (DUF2132)
HC680_13180	COG2207	Transcriptional regulator
HC680_13215	COG3195	allantoin biosynthetic process
HC680_13215	COG3648	Uricase
HC680_13220	COG2351	hydroxyisourate hydrolase activity
HC680_13225	COG1396	sequence-specific DNA binding
HC680_13230	COG3550	peptidyl-serine autophosphorylation
HC680_13245	COG3188	usher protein
HC680_13280	COG5001	Diguanylate cyclase
HC680_13280	COG3300	MHYT domain
HC680_13285	COG2819	hydrolase of the alpha beta superfamily
HC680_13290	COG4644	lycopene metabolic process
HC680_13315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_13315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_13320	COG2814	Major facilitator Superfamily
HC680_13335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC680_13335	COG1263	PTS System
HC680_13340	COG2186	Transcriptional regulator
HC680_13360	COG3835	regulator
HC680_13365	COG1929	Belongs to the glycerate kinase type-1 family
HC680_13405	COG0583	DNA-binding transcription factor activity
HC680_13435	COG3118	belongs to the thioredoxin family
HC680_13445	COG1271	oxidase subunit
HC680_13450	COG1294	oxidase, subunit
HC680_13460	COG0583	DNA-binding transcription factor activity
HC680_13465	COG0814	amino acid
HC680_13470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC680_13475	COG0626	cystathionine gamma-synthase activity
HC680_13480	COG0583	DNA-binding transcription factor activity
HC680_13485	COG0251	oxidation-reduction process
HC680_13500	COG1473	amidohydrolase
HC680_13515	COG0667	Aldo Keto reductase
HC680_13520	COG3386	PFAM SMP-30 Gluconolaconase
HC680_13525	COG0667	Aldo Keto reductase
HC680_13530	COG0667	Aldo Keto reductase
HC680_13540	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HC680_13540	COG0456	acetyltransferase
HC680_13565	COG1652	LysM domain
HC680_13595	COG1609	Transcriptional regulator
HC680_13605	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC680_13620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC680_13630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC680_13635	COG0583	DNA-binding transcription factor activity
HC680_13640	COG0583	DNA-binding transcription factor activity
HC680_13655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC680_13655	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HC680_13655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC680_13660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC680_13680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC680_13685	COG3037	sugar-specific permease SgaT UlaA
HC680_13695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_13700	COG1609	Transcriptional regulator
HC680_13710	COG2223	nitrite transmembrane transporter activity
HC680_13740	COG0477	Major facilitator Superfamily
HC680_13745	COG4529	Protein conserved in bacteria
HC680_13750	COG1902	pentaerythritol trinitrate reductase activity
HC680_13760	COG0583	DNA-binding transcription factor activity
HC680_13765	COG2070	2-Nitropropane dioxygenase
HC680_13775	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HC680_13830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HC680_13880	COG2207	Transcriptional regulator
HC680_13900	COG1335	isochorismatase
HC680_13905	COG0406	alpha-ribazole phosphatase activity
HC680_13945	COG1953	Uracil, thiamine, allantoin
HC680_13950	COG0402	S-adenosylhomocysteine deaminase activity
HC680_13955	COG3706	GGDEF domain
HC680_13960	COG1609	Transcriptional regulator
HC680_13970	COG0673	inositol 2-dehydrogenase activity
HC680_13980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HC680_13985	COG1116	anion transmembrane transporter activity
HC680_13990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC680_13995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC680_14000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC680_14005	COG0076	glutamate decarboxylase activity
HC680_14020	COG2205	protein histidine kinase activity
HC680_14025	COG0745	RESPONSE REGULATOR receiver
HC680_14030	COG0596	Alpha beta hydrolase
HC680_14070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HC680_14070	COG0519	Catalyzes the synthesis of GMP from XMP
HC680_14090	COG0583	DNA-binding transcription factor activity
HC680_14100	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HC680_14105	COG1285	pathogenesis
HC680_14110	COG2814	Major facilitator Superfamily
HC680_14115	COG0583	DNA-binding transcription factor activity
HC680_14120	COG0243	molybdopterin cofactor binding
HC680_14125	COG3781	membrane
HC680_14150	COG1764	response to oxidative stress
HC680_14160	COG3111	PFAM Bacterial OB fold (BOF) protein
HC680_14170	COG2323	membrane
HC680_14180	COG0366	Alpha amylase catalytic
HC680_14190	COG3685	Protein conserved in bacteria
HC680_14200	COG3729	General stress protein
HC680_14205	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_14250	COG0488	(ABC) transporter
HC680_14265	COG1064	alcohol dehydrogenase
HC680_14270	COG0747	negative chemotaxis
HC680_14290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC680_14300	COG2814	Major facilitator Superfamily
HC680_14310	COG2326	polyphosphate kinase activity
HC680_14325	COG2864	formate dehydrogenase
HC680_14330	COG0437	4 iron, 4 sulfur cluster binding
HC680_14355	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HC680_14365	COG3485	protocatechuate 3,4-dioxygenase
HC680_14370	COG4829	muconolactone delta-isomerase
HC680_14375	COG4948	Mandelate Racemase Muconate Lactonizing
HC680_14380	COG1414	Transcriptional regulator
HC680_14400	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HC680_14405	COG1140	nitrate reductase beta subunit
HC680_14410	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HC680_14415	COG2181	nitrate reductase activity
HC680_14425	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HC680_14430	COG1178	ABC-type Fe3 transport system permease component
HC680_14435	COG1840	ABC-type Fe3 transport system, periplasmic component
HC680_14440	COG3842	ATPase activity
HC680_14445	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC680_14455	COG0625	glutathione transferase activity
HC680_14465	COG1126	abc transporter atp-binding protein
HC680_14470	COG0765	amino acid transport
HC680_14485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC680_14490	COG1473	amidohydrolase
HC680_14495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC680_14500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC680_14525	COG4772	TonB-dependent receptor
HC680_14530	COG1228	amidohydrolase
HC680_14535	COG3691	Protein conserved in bacteria
HC680_14550	COG2130	NADP-dependent
HC680_14560	COG1247	-acetyltransferase
HC680_14565	COG3238	Protein conserved in bacteria
HC680_14575	COG0747	negative chemotaxis
HC680_14585	COG1012	belongs to the aldehyde dehydrogenase family
HC680_14620	COG1012	belongs to the aldehyde dehydrogenase family
HC680_14625	COG1177	transmembrane transport
HC680_14630	COG1176	ABC-type spermidine putrescine transport system, permease component I
HC680_14635	COG3842	ATPase activity
HC680_14640	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HC680_14645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC680_14650	COG1271	oxidase subunit
HC680_14655	COG1294	oxidase, subunit
HC680_14675	COG0826	peptidase U32
HC680_14685	COG1396	sequence-specific DNA binding
HC680_14690	COG3135	benzoate transporter
HC680_14695	COG2207	Transcriptional regulator
HC680_14695	COG3708	Transcriptional regulator
HC680_14700	COG0697	spore germination
HC680_14710	COG0500	methyltransferase
HC680_14715	COG1275	C4-dicarboxylate transporter malic acid transport protein
HC680_14720	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HC680_14725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC680_14740	COG2272	Belongs to the type-B carboxylesterase lipase family
HC680_14745	COG5383	Protein conserved in bacteria
HC680_14750	COG3485	protocatechuate 3,4-dioxygenase
HC680_14755	COG3485	protocatechuate 3,4-dioxygenase
HC680_14760	COG0583	DNA-binding transcription factor activity
HC680_14780	COG3038	cytochrome b561
HC680_14800	COG2814	Major facilitator Superfamily
HC680_14810	COG0673	inositol 2-dehydrogenase activity
HC680_14820	COG2723	6-phospho-beta-galactosidase activity
HC680_14855	COG4659	FMN binding
HC680_14865	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HC680_14875	COG0625	glutathione transferase activity
HC680_14880	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HC680_14895	COG3895	Periplasmic Protein
HC680_14910	COG3706	GGDEF domain
HC680_14925	COG1566	PFAM secretion protein HlyD family protein
HC680_14930	COG1289	transmembrane transporter activity
HC680_14935	COG2032	superoxide dismutase activity
HC680_14940	COG4989	oxidoreductase activity
HC680_14945	COG3313	Fe-S protein
HC680_14950	COG1309	transcriptional regulator
HC680_14955	COG1902	pentaerythritol trinitrate reductase activity
HC680_14960	COG0346	lactoylglutathione lyase activity
HC680_14970	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HC680_14975	COG0791	NLP P60 protein
HC680_14990	COG2814	Major facilitator Superfamily
HC680_15005	COG0583	DNA-binding transcription factor activity
HC680_15010	COG2814	Major facilitator Superfamily
HC680_15015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HC680_15020	COG0307	riboflavin synthase, alpha
HC680_15065	COG0300	oxidoreductase activity
HC680_15085	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HC680_15125	COG1349	DNA-binding transcription factor activity
HC680_15130	COG0346	lactoylglutathione lyase activity
HC680_15155	COG0444	Belongs to the ABC transporter superfamily
HC680_15160	COG4608	Belongs to the ABC transporter superfamily
HC680_15190	COG0531	amino acid
HC680_15195	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_15205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC680_15240	COG0402	S-adenosylhomocysteine deaminase activity
HC680_15265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC680_15270	COG0277	FAD linked oxidase domain protein
HC680_15285	COG2814	Major facilitator Superfamily
HC680_15315	COG0583	DNA-binding transcription factor activity
HC680_15325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC680_15335	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC680_15340	COG2610	gluconate transmembrane transporter activity
HC680_15345	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_15380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC680_15395	COG0745	RESPONSE REGULATOR receiver
HC680_15400	COG5002	protein histidine kinase activity
HC680_15400	COG3850	Histidine kinase
HC680_15425	COG3088	subunit of a heme lyase
HC680_15425	COG4235	cytochrome complex assembly
HC680_15430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC680_15435	COG1138	Cytochrome C-type biogenesis protein
HC680_15450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC680_15455	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC680_15460	COG4133	protoheme IX ABC transporter activity
HC680_15490	COG1175	transmembrane transport
HC680_15505	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HC680_15510	COG3383	formate dehydrogenase (NAD+) activity
HC680_15550	COG1126	abc transporter atp-binding protein
HC680_15555	COG0765	amino acid transport
HC680_15575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC680_15580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC680_15585	COG1120	ATPase activity
HC680_15590	COG4774	siderophore transport
HC680_15595	COG1116	anion transmembrane transporter activity
HC680_15600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC680_15620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC680_15625	COG0583	DNA-binding transcription factor activity
HC680_15645	COG2814	Major facilitator Superfamily
HC680_15680	COG1414	Transcriptional regulator
HC680_15705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC680_15710	COG2271	Major facilitator Superfamily
HC680_15720	COG1309	transcriptional regulator
HC680_15750	COG1376	ErfK ybiS ycfS ynhG family protein
HC680_15765	COG0719	Fe-S assembly protein
HC680_15770	COG0396	ATPase activity
HC680_15775	COG0719	Fe-S assembly protein
HC680_15780	COG0316	Belongs to the HesB IscA family
HC680_15800	COG1309	transcriptional regulator
HC680_15805	COG1304	FMN binding
HC680_15830	COG0583	DNA-binding transcription factor activity
HC680_15840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC680_15845	COG1120	ATPase activity
HC680_15870	COG2261	transglycosylase associated protein
HC680_15875	COG2050	protein possibly involved in aromatic compounds catabolism
HC680_15880	COG0277	FAD linked oxidase domain protein
HC680_15880	COG0247	lactate metabolic process
HC680_15885	COG0628	permease
HC680_15895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC680_15895	COG0574	Belongs to the PEP-utilizing enzyme family
HC680_15910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HC680_15915	COG4256	Hemin uptake protein
HC680_15925	COG0791	NLP P60 protein
HC680_15935	COG0386	Belongs to the glutathione peroxidase family
HC680_15955	COG0583	DNA-binding transcription factor activity
HC680_15975	COG0072	phenylalanine-tRNA ligase activity
HC680_15975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC680_16015	COG3137	Salt-induced outer membrane protein
HC680_16020	COG1105	Belongs to the carbohydrate kinase PfkB family
HC680_16030	COG3001	Fructosamine kinase
HC680_16080	COG2350	Protein conserved in bacteria
HC680_16090	COG2353	YceI-like domain
HC680_16110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC680_16120	COG0444	Belongs to the ABC transporter superfamily
HC680_16125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC680_16130	COG0601	transmembrane transport
HC680_16135	COG4166	transmembrane transport
HC680_16145	COG2095	MarC family integral membrane protein
HC680_16155	COG1012	belongs to the aldehyde dehydrogenase family
HC680_16155	COG1454	alcohol dehydrogenase
HC680_16160	COG1435	thymidine kinase activity
HC680_16170	COG2916	Histone family protein nucleoid-structuring protein H-NS
HC680_16175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC680_16180	COG0745	RESPONSE REGULATOR receiver
HC680_16185	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC680_16195	COG0788	formyltetrahydrofolate deformylase activity
HC680_16230	COG1522	sequence-specific DNA binding
HC680_16240	COG2181	nitrate reductase activity
HC680_16245	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HC680_16250	COG1140	nitrate reductase beta subunit
HC680_16255	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HC680_16265	COG2223	nitrite transmembrane transporter activity
HC680_16270	COG3850	Histidine kinase
HC680_16275	COG2197	response regulator
HC680_16280	COG4932	domain protein
HC680_16285	COG0243	molybdopterin cofactor binding
HC680_16290	COG2146	nitrite reductase [NAD(P)H] activity
HC680_16290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC680_16295	COG1116	anion transmembrane transporter activity
HC680_16305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC680_16315	COG3707	response regulator
HC680_16320	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HC680_16330	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HC680_16335	COG4572	Cation transport regulator
HC680_16340	COG0387	Pfam Sodium calcium exchanger
HC680_16360	COG2890	protein-(glutamine-N5) methyltransferase activity
HC680_16390	COG0659	secondary active sulfate transmembrane transporter activity
HC680_16410	COG0012	GTP binding
HC680_16475	COG1388	LysM domain
HC680_16480	COG3501	Rhs element vgr protein
HC680_16490	COG2885	chlorophyll binding
HC680_16515	COG3122	Protein conserved in bacteria
HC680_16530	COG0583	DNA-binding transcription factor activity
HC680_16560	COG0583	DNA-binding transcription factor activity
HC680_16595	COG1882	Formate acetyltransferase
HC680_16610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC680_16615	COG0583	DNA-binding transcription factor activity
HC680_16655	COG2308	Evidence 4 Homologs of previously reported genes of
HC680_16665	COG2211	Major facilitator Superfamily
HC680_16675	COG4774	siderophore transport
HC680_16685	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC680_16710	COG2719	SpoVR family
HC680_16740	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC680_16755	COG2894	cell division
HC680_16765	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HC680_16775	COG3065	identical protein binding
HC680_16785	COG1199	ATP-dependent helicase activity
HC680_16790	COG0251	oxidation-reduction process
HC680_16810	COG1760	l-serine dehydratase
HC680_16820	COG2200	EAL domain
HC680_16825	COG1253	flavin adenine dinucleotide binding
HC680_16830	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_16830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC680_16835	COG3715	PTS system
HC680_16840	COG3716	PTS system mannose fructose sorbose family IID component
HC680_16855	COG2226	methyltransferase
HC680_16860	COG0768	penicillin binding
HC680_16895	COG1414	Transcriptional regulator
HC680_16900	COG2814	Major facilitator Superfamily
HC680_16920	COG1956	GAF domain-containing protein
HC680_16925	COG2995	paraquat-inducible protein a
HC680_16930	COG3008	intermembrane lipid transfer
HC680_16955	COG2990	Protein conserved in bacteria
HC680_16970	COG1276	copper resistance
HC680_16975	COG2372	response to copper ion
HC680_16985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC680_16990	COG1770	oligopeptidase
HC680_16995	COG2979	Protein of unknown function (DUF533)
HC680_17000	COG3141	response to X-ray
HC680_17010	COG0800	Aldolase
HC680_17015	COG0129	dihydroxy-acid dehydratase activity
HC680_17020	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HC680_17030	COG1737	Transcriptional regulator
HC680_17040	COG1560	Kdo2-lipid A biosynthetic process
HC680_17045	COG0739	heme binding
HC680_17050	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HC680_17060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC680_17085	COG0494	nUDIX hydrolase
HC680_17095	COG1335	isochorismatase
HC680_17100	COG1801	Protein of unknown function DUF72
HC680_17105	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HC680_17125	COG3102	Protein conserved in bacteria
HC680_17135	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC680_17160	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC680_17170	COG1879	ABC-type sugar transport system periplasmic component
HC680_17180	COG1528	Iron-storage protein
HC680_17190	COG2211	Major facilitator Superfamily
HC680_17200	COG0477	Major facilitator Superfamily
HC680_17215	COG1528	Iron-storage protein
HC680_17225	COG0814	amino acid
HC680_17230	COG3012	SEC-C Motif Domain Protein
HC680_17230	COG3318	Belongs to the UPF0149 family
HC680_17245	COG3772	lysozyme
HC680_17405	COG0305	Participates in initiation and elongation during chromosome replication
HC680_17495	COG2197	response regulator
HC680_17505	COG2197	response regulator
HC680_17530	COG0366	Alpha amylase catalytic
HC680_17560	COG2354	Protein conserved in bacteria
HC680_17565	COG0697	spore germination
HC680_17570	COG3727	T/G mismatch-specific endonuclease activity
HC680_17575	COG0270	DNA (cytosine-5-)-methyltransferase activity
HC680_17580	COG1418	mRNA catabolic process
HC680_17595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HC680_17610	COG3344	reverse transcriptase
HC680_17620	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC680_17810	COG1403	HNH endonuclease
HC680_17815	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HC680_17825	COG1846	Transcriptional regulator
HC680_17840	COG4197	protein conserved in bacteria, prophage-related
HC680_17940	COG0025	NhaP-type Na H and K H
HC680_17945	COG1309	transcriptional regulator
HC680_17950	COG0604	alcohol dehydrogenase
HC680_17970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HC680_17980	COG0534	Mate efflux family protein
HC680_17995	COG0582	viral genome integration into host DNA
HC680_18010	COG1737	Transcriptional regulator
HC680_18025	COG2814	Major facilitator Superfamily
HC680_18030	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_18045	COG4977	sequence-specific DNA binding
HC680_18050	COG1566	PFAM secretion protein HlyD family protein
HC680_18065	COG2207	Transcriptional regulator
HC680_18085	COG3706	GGDEF domain
HC680_18110	COG3615	Tellurite resistance protein tehB
HC680_18120	COG3300	MHYT domain
HC680_18120	COG5001	Diguanylate cyclase
HC680_18130	COG0477	Major facilitator Superfamily
HC680_18135	COG0095	Lipoate-protein ligase
HC680_18140	COG0583	DNA-binding transcription factor activity
HC680_18145	COG1942	4-Oxalocrotonate Tautomerase
HC680_18155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HC680_18175	COG1289	transmembrane transporter activity
HC680_18190	COG2925	Exonuclease
HC680_18195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HC680_18200	COG0640	Transcriptional regulator
HC680_18205	COG0531	amino acid
HC680_18215	COG0583	DNA-binding transcription factor activity
HC680_18220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC680_18250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HC680_18275	COG0463	Glycosyl transferase, family 2
HC680_18285	COG1215	transferase activity, transferring glycosyl groups
HC680_18290	COG0438	transferase activity, transferring glycosyl groups
HC680_18425	COG1253	flavin adenine dinucleotide binding
HC680_18430	COG2982	Protein involved in outer membrane biogenesis
HC680_18445	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC680_18450	COG0443	Heat shock 70 kDa protein
HC680_18455	COG5002	protein histidine kinase activity
HC680_18475	COG1301	dicarboxylic acid transport
HC680_18500	COG2205	protein histidine kinase activity
HC680_18505	COG0745	RESPONSE REGULATOR receiver
HC680_18520	COG4608	Belongs to the ABC transporter superfamily
HC680_18525	COG0444	Belongs to the ABC transporter superfamily
HC680_18535	COG0601	transmembrane transport
HC680_18540	COG0747	negative chemotaxis
HC680_18545	COG4948	Mandelate Racemase Muconate Lactonizing
HC680_18550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC680_18560	COG1070	Carbohydrate kinase
HC680_18595	COG1830	Aldolase
HC680_18600	COG0351	phosphomethylpyrimidine kinase
HC680_18615	COG0583	DNA-binding transcription factor activity
HC680_18625	COG2252	PERMEase
HC680_18630	COG0583	DNA-binding transcription factor activity
HC680_18635	COG5455	response to cobalt ion
HC680_18655	COG4807	Protein conserved in bacteria
HC680_18665	COG3275	phosphorelay sensor kinase activity
HC680_18675	COG1174	glycine betaine transport
HC680_18680	COG1125	glycine betaine transport
HC680_18685	COG1174	glycine betaine transport
HC680_18690	COG1732	Glycine betaine
HC680_18695	COG1472	Belongs to the glycosyl hydrolase 3 family
HC680_18700	COG0277	FAD linked oxidase domain protein
HC680_18710	COG1686	Belongs to the peptidase S11 family
HC680_18720	COG0586	Pfam SNARE associated Golgi protein
HC680_18735	COG2723	6-phospho-beta-galactosidase activity
HC680_18750	COG3659	wide pore channel activity
HC680_18755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC680_18765	COG1346	cytolysis
HC680_18775	COG2949	membrane
HC680_18785	COG1129	ABC transporter
HC680_18800	COG2311	Membrane
HC680_18815	COG4771	TonB-dependent receptor
HC680_18820	COG0833	amino acid
HC680_18825	COG0583	DNA-binding transcription factor activity
HC680_18830	COG2855	membrane
HC680_18840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC680_18840	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HC680_18840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC680_18845	COG1105	Belongs to the carbohydrate kinase PfkB family
HC680_18850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_18850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_18870	COG1312	Catalyzes the dehydration of D-mannonate
HC680_18875	COG0246	Mannitol dehydrogenase
HC680_18880	COG0523	cobalamin synthesis protein
HC680_18885	COG0671	phosphoesterase, PA-phosphatase related
HC680_18890	COG0791	NLP P60 protein
HC680_18895	COG2200	EAL domain
HC680_18900	COG4166	transmembrane transport
HC680_18905	COG4174	ABC transporter (Permease)
HC680_18910	COG4239	(ABC) transporter, permease
HC680_18915	COG4172	Belongs to the ABC transporter superfamily
HC680_18925	COG2814	Major facilitator Superfamily
HC680_18930	COG1187	pseudouridine synthase activity
HC680_18935	COG1061	Type III restriction enzyme res subunit
HC680_18955	COG0494	nUDIX hydrolase
HC680_18960	COG1349	DNA-binding transcription factor activity
HC680_18985	COG0628	permease
HC680_19000	COG0659	secondary active sulfate transmembrane transporter activity
HC680_19005	COG2239	Acts as a magnesium transporter
HC680_19010	COG4615	Cyclic peptide transporter
HC680_19015	COG3145	DNA-N1-methyladenine dioxygenase activity
HC680_19020	COG2169	Transcriptional regulator
HC680_19020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC680_19035	COG0642	Histidine kinase
HC680_19035	COG2198	Histidine kinase
HC680_19045	COG2205	protein histidine kinase activity
HC680_19045	COG0784	Response regulator, receiver
HC680_19050	COG3852	Histidine kinase
HC680_19055	COG2204	response regulator
HC680_19060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC680_19065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC680_19070	COG2031	fatty acid transporter
HC680_19075	COG0183	Belongs to the thiolase family
HC680_19100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC680_19105	COG0584	glycerophosphoryl diester phosphodiesterase
HC680_19110	COG2271	Major facilitator Superfamily
HC680_19115	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HC680_19125	COG0247	lactate metabolic process
HC680_19135	COG2271	Major facilitator Superfamily
HC680_19145	COG1414	Transcriptional regulator
HC680_19165	COG5464	transposase or invertase
HC680_19175	COG0318	PFAM AMP-dependent synthetase and ligase
HC680_19200	COG1169	isochorismate synthase
HC680_19205	COG2153	protein acetylation
HC680_19220	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC680_19225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC680_19235	COG0839	Belongs to the complex I subunit 6 family
HC680_19285	COG0583	DNA-binding transcription factor activity
HC680_19290	COG0436	Aminotransferase
HC680_19300	COG0471	metal ion transport
HC680_19300	COG0490	domain, Protein
HC680_19305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC680_19325	COG0857	belongs to the CobB CobQ family
HC680_19325	COG0280	phosphate acetyltransferase
HC680_19330	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HC680_19335	COG0622	Phosphoesterase
HC680_19340	COG0625	glutathione transferase activity
HC680_19345	COG0625	glutathione transferase activity
HC680_19350	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HC680_19355	COG1090	epimerase
HC680_19370	COG4598	ABC transporter
HC680_19375	COG4160	amino acid transport
HC680_19400	COG0163	prenyltransferase activity
HC680_19405	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HC680_19410	COG1286	toxin biosynthetic process
HC680_19415	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HC680_19420	COG0285	dihydrofolate synthase activity
HC680_19430	COG0586	Pfam SNARE associated Golgi protein
HC680_19440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HC680_19460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC680_19475	COG3101	peptidyl-lysine hydroxylation
HC680_19480	COG0730	response to heat
HC680_19505	COG2062	phosphohistidine phosphatase, SixA
HC680_19520	COG3691	Protein conserved in bacteria
HC680_19530	COG2853	Lipoprotein
HC680_19535	COG2116	formate transmembrane transporter activity
HC680_19550	COG3344	reverse transcriptase
HC680_19555	COG3344	reverse transcriptase
HC680_19670	COG4626	Terminase
HC680_19670	COG1802	Transcriptional regulator
HC680_19740	COG1403	HNH endonuclease
HC680_19745	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HC680_19755	COG1846	Transcriptional regulator
HC680_19775	COG1396	sequence-specific DNA binding
HC680_19825	COG0582	viral genome integration into host DNA
HC680_19845	COG0583	DNA-binding transcription factor activity
HC680_19850	COG0590	tRNA wobble adenosine to inosine editing
HC680_19855	COG2807	transmembrane transport
HC680_19865	COG0436	Aminotransferase
HC680_19880	COG3275	phosphorelay sensor kinase activity
HC680_19885	COG3279	Response regulator of the LytR AlgR family
HC680_19900	COG3961	Belongs to the TPP enzyme family
HC680_19905	COG0667	Aldo Keto reductase
HC680_19920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC680_19925	COG2200	EAL domain
HC680_19925	COG2199	diguanylate cyclase activity
HC680_19940	COG3415	Transposase
HC680_19945	COG3415	Transposase
HC680_19975	COG0583	DNA-binding transcription factor activity
HC680_19980	COG0385	Bile acid
HC680_19985	COG3530	Putative quorum-sensing-regulated virulence factor
HC680_20005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC680_20045	COG4319	ketosteroid isomerase
HC680_20055	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HC680_20060	COG4208	sulfate ABC transporter
HC680_20065	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HC680_20070	COG4150	thiosulfate binding
HC680_20080	COG2837	iron assimilation
HC680_20100	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC680_20190	COG4810	utilization protein
HC680_20200	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC680_20205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HC680_20210	COG5342	invasion associated locus B
HC680_20220	COG0493	'glutamate synthase
HC680_20220	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HC680_20225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC680_20235	COG1393	Belongs to the ArsC family
HC680_20250	COG0400	carboxylic ester hydrolase activity
HC680_20255	COG1444	tRNA N-acetyltransferase activity
HC680_20260	COG2321	neutral zinc metallopeptidase
HC680_20270	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HC680_20280	COG2716	regulation of RNA biosynthetic process
HC680_20285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HC680_20290	COG0628	permease
HC680_20300	COG4783	chaperone-mediated protein folding
HC680_20305	COG1393	Belongs to the ArsC family
HC680_20320	COG2233	PERMEase
HC680_20330	COG2723	6-phospho-beta-galactosidase activity
HC680_20345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HC680_20360	COG2200	EAL domain
HC680_20380	COG0641	radical SAM
HC680_20385	COG3119	arylsulfatase activity
HC680_20395	COG0517	IMP dehydrogenase activity
HC680_20395	COG0516	GMP reductase activity
HC680_20405	COG1645	bacterial-type flagellum-dependent swarming motility
HC680_20425	COG2976	Protein conserved in bacteria
HC680_20455	COG4953	penicillin-binding protein 1C
HC680_20460	COG2373	Large extracellular alpha-helical protein
HC680_20465	COG2897	thiosulfate sulfurtransferase activity
HC680_20485	COG2975	iron-sulfur cluster assembly
HC680_20490	COG0633	Ferredoxin
HC680_20510	COG0822	iron-sulfur transferase activity
HC680_20540	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HC680_20545	COG3683	transport system, periplasmic component
HC680_20550	COG3711	transcriptional antiterminator
HC680_20555	COG2814	Major facilitator Superfamily
HC680_20560	COG2017	converts alpha-aldose to the beta-anomer
HC680_20565	COG2814	Major facilitator Superfamily
HC680_20565	COG0477	Major facilitator Superfamily
HC680_20570	COG0457	Tetratricopeptide repeat
HC680_20575	COG1940	carbohydrate kinase activity
HC680_20580	COG2259	Doxx family
HC680_20590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC680_20590	COG1017	nitric oxide dioxygenase activity
HC680_20595	COG0347	Belongs to the P(II) protein family
HC680_20600	COG2204	response regulator
HC680_20605	COG3170	Tfp pilus assembly protein FimV
HC680_20610	COG2205	protein histidine kinase activity
HC680_20615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC680_20615	COG0047	phosphoribosylformylglycinamidine synthase activity
HC680_20630	COG0560	Phosphoserine phosphatase
HC680_20635	COG1737	Transcriptional regulator
HC680_20640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HC680_20650	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HC680_20670	COG0681	Belongs to the peptidase S26 family
HC680_20690	COG3344	reverse transcriptase
HC680_20750	COG1846	Transcriptional regulator
HC680_20785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC680_20820	COG3086	response to oxidative stress
HC680_20825	COG3026	antisigma factor binding
HC680_20830	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HC680_20845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HC680_20855	COG0513	Belongs to the DEAD box helicase family
HC680_20870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC680_20875	COG3118	belongs to the thioredoxin family
HC680_20890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC680_20895	COG5544	Lipoprotein
HC680_20900	COG0477	Major facilitator Superfamily
HC680_20925	COG0542	response to heat
HC680_20940	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC680_20945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HC680_20955	COG1605	Chorismate mutase
HC680_20955	COG0077	Prephenate dehydratase
HC680_20965	COG0287	Prephenate dehydrogenase
HC680_20965	COG1605	Chorismate mutase
HC680_20970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HC680_20980	COG2199	diguanylate cyclase activity
HC680_20985	COG2885	chlorophyll binding
HC680_21025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HC680_21030	COG4137	Cytochrome C assembly protein
HC680_21035	COG4536	flavin adenine dinucleotide binding
HC680_21050	COG0497	DNA recombination
HC680_21070	COG2867	negative regulation of translational initiation
HC680_21135	COG2207	Transcriptional regulator
HC680_21135	COG3708	Transcriptional regulator
HC680_21140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC680_21175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC680_21185	COG0235	Class ii aldolase
HC680_21195	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_21210	COG2197	response regulator
HC680_21215	COG3539	Fimbrial protein
HC680_21225	COG3188	usher protein
HC680_21245	COG3121	Chaperone
HC680_21250	COG3539	Fimbrial protein
HC680_21255	COG1012	belongs to the aldehyde dehydrogenase family
HC680_21260	COG3284	Transcriptional regulator
HC680_21265	COG0583	DNA-binding transcription factor activity
HC680_21275	COG0640	Transcriptional regulator
HC680_21280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC680_21295	COG2916	Histone family protein nucleoid-structuring protein H-NS
HC680_21315	COG4575	ribosome binding
HC680_21320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC680_21325	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC680_21330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HC680_21340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC680_21355	COG4176	ABC-type proline glycine betaine transport system permease component
HC680_21365	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HC680_21380	COG1846	Transcriptional regulator
HC680_21390	COG1566	PFAM secretion protein HlyD family protein
HC680_21395	COG2814	Major facilitator Superfamily
HC680_21400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC680_21420	COG1238	metal cluster binding
HC680_21425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC680_21430	COG2823	Periplasmic or secreted lipoprotein
HC680_21465	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HC680_21485	COG1546	Belongs to the CinA family
HC680_21490	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC680_21495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC680_21500	COG1121	(ABC) transporter
HC680_21505	COG2951	lytic endotransglycosylase activity
HC680_21510	COG3730	PTS system glucitol sorbitol-specific
HC680_21515	COG3732	PTS system glucitol sorbitol-specific
HC680_21525	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_21530	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_21535	COG1349	DNA-binding transcription factor activity
HC680_21565	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HC680_21570	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HC680_21575	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HC680_21580	COG1609	Transcriptional regulator
HC680_21590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC680_21590	COG1263	PTS System
HC680_21595	COG2723	6-phospho-beta-galactosidase activity
HC680_21605	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HC680_21615	COG3260	NADH ubiquinone oxidoreductase 20
HC680_21620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC680_21625	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HC680_21625	COG3261	NADH dehydrogenase
HC680_21630	COG0650	Formate hydrogenlyase subunit 4
HC680_21635	COG0651	ATP synthesis coupled electron transport
HC680_21640	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HC680_21655	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HC680_21660	COG0298	carbon dioxide binding
HC680_21665	COG0409	Hydrogenase expression formation protein
HC680_21670	COG0309	Hydrogenase expression formation protein (HypE)
HC680_21680	COG2723	6-phospho-beta-galactosidase activity
HC680_21690	COG4580	involved in the transport of maltose and maltodextrins
HC680_21695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC680_21700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC680_21705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC680_21710	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC680_21715	COG1940	carbohydrate kinase activity
HC680_21720	COG1609	Transcriptional regulator
HC680_21730	COG1121	(ABC) transporter
HC680_21735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC680_21740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC680_21755	COG0679	Auxin Efflux Carrier
HC680_21775	COG3720	iron ion transport
HC680_21780	COG4558	Periplasmic binding protein
HC680_21785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC680_21825	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HC680_21830	COG0163	prenyltransferase activity
HC680_21855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC680_21860	COG4942	peptidase
HC680_21860	COG1388	LysM domain
HC680_21920	COG2234	aminopeptidase activity
HC680_21940	COG0720	synthase
HC680_21945	COG0602	queuosine metabolic process
HC680_21970	COG3956	TIGRFAM MazG family protein
HC680_21975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC680_21985	COG2205	protein histidine kinase activity
HC680_21985	COG3850	Histidine kinase
HC680_21985	COG4999	Histidine kinase
HC680_21985	COG3437	response regulator, receiver
HC680_21990	COG1929	Belongs to the glycerate kinase type-1 family
HC680_21995	COG4948	Mandelate Racemase Muconate Lactonizing
HC680_22000	COG4948	Mandelate Racemase Muconate Lactonizing
HC680_22005	COG2271	Major facilitator Superfamily
HC680_22010	COG0716	FMN binding
HC680_22015	COG0564	pseudouridine synthase activity
HC680_22020	COG3098	single-species biofilm formation
HC680_22035	COG1611	Belongs to the LOG family
HC680_22040	COG0814	amino acid
HC680_22045	COG1760	l-serine dehydratase
HC680_22050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC680_22060	COG0477	Major facilitator Superfamily
HC680_22065	COG1464	Belongs to the NlpA lipoprotein family
HC680_22070	COG2011	ABC-type metal ion transport system permease component
HC680_22075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC680_22090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC680_22110	COG1454	alcohol dehydrogenase
HC680_22115	COG0235	Class ii aldolase
HC680_22125	COG0738	Major facilitator superfamily
HC680_22145	COG1349	DNA-binding transcription factor activity
HC680_22155	COG2363	Small membrane protein
HC680_22160	COG0583	DNA-binding transcription factor activity
HC680_22170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC680_22175	COG2166	iron-sulfur cluster assembly
HC680_22180	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HC680_22185	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HC680_22365	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HC680_22380	COG1454	alcohol dehydrogenase
HC680_22380	COG1012	belongs to the aldehyde dehydrogenase family
HC680_22385	COG4656	Part of a membrane complex involved in electron transport
HC680_22415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HC680_22420	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC680_22425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HC680_22425	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HC680_22435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HC680_22445	COG1025	Belongs to the peptidase M16 family
HC680_22450	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HC680_22455	COG4967	type IV pilus modification protein PilV
HC680_22465	COG4795	General secretion pathway protein
HC680_22470	COG2165	general secretion pathway protein
HC680_22505	COG0861	Integral membrane protein TerC family
HC680_22515	COG0667	Aldo Keto reductase
HC680_22530	COG1609	Transcriptional regulator
HC680_22540	COG2186	Transcriptional regulator
HC680_22545	COG2723	6-phospho-beta-galactosidase activity
HC680_22550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC680_22555	COG1609	Transcriptional regulator
HC680_22565	COG0583	DNA-binding transcription factor activity
HC680_22570	COG1794	racemase activity, acting on amino acids and derivatives
HC680_22575	COG1917	Cupin 2, conserved barrel domain protein
HC680_22580	COG1175	transmembrane transport
HC680_22585	COG0395	ABC-type sugar transport system, permease component
HC680_22590	COG3842	ATPase activity
HC680_22625	COG2814	Major facilitator Superfamily
HC680_22630	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_22640	COG0823	Involved in the tonB-independent uptake of proteins
HC680_22650	COG0183	Belongs to the thiolase family
HC680_22665	COG0814	amino acid
HC680_22670	COG0667	Aldo Keto reductase
HC680_22720	COG0697	spore germination
HC680_22725	COG1846	Transcriptional regulator
HC680_22730	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HC680_22735	COG0582	viral genome integration into host DNA
HC680_22740	COG4974	Belongs to the 'phage' integrase family
HC680_22755	COG3539	Fimbrial protein
HC680_22760	COG3121	Chaperone
HC680_22765	COG3188	usher protein
HC680_22770	COG3539	Fimbrial protein
HC680_22775	COG3539	Fimbrial protein
HC680_22780	COG3539	Fimbrial protein
HC680_22790	COG2388	GCN5-related N-acetyl-transferase
HC680_22795	COG3592	Divergent 4Fe-4S mono-cluster
HC680_22810	COG1289	transmembrane transporter activity
HC680_22815	COG1538	Outer membrane efflux protein
HC680_22825	COG3104	oligopeptide transport
HC680_22830	COG1393	Belongs to the ArsC family
HC680_22835	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC680_22875	COG0667	Aldo Keto reductase
HC680_22890	COG2814	Major facilitator Superfamily
HC680_22900	COG4942	peptidase
HC680_22925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HC680_22935	COG4974	Belongs to the 'phage' integrase family
HC680_22940	COG0716	FMN binding
HC680_22950	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HC680_22960	COG1272	protein, Hemolysin III
HC680_22970	COG1737	Transcriptional regulator
HC680_22975	COG2723	6-phospho-beta-galactosidase activity
HC680_22995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC680_23005	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_23025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC680_23030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC680_23035	COG0006	proline dipeptidase activity
HC680_23055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HC680_23060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC680_23080	COG2968	Membrane
HC680_23090	COG0668	transmembrane transport
HC680_23095	COG0191	fructose-bisphosphate aldolase activity
HC680_23110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HC680_23115	COG0501	Belongs to the peptidase M48B family
HC680_23135	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HC680_23140	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_23170	COG1414	Transcriptional regulator
HC680_23175	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_23190	COG2146	nitrite reductase [NAD(P)H] activity
HC680_23225	COG2814	Major facilitator Superfamily
HC680_23235	COG2356	endonuclease I
HC680_23240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HC680_23245	COG0189	ligase activity
HC680_23270	COG2805	Type II/IV secretion system protein
HC680_23275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HC680_23280	COG0762	integral membrane protein
HC680_23295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC680_23310	COG4214	carbohydrate transport
HC680_23320	COG3171	Protein conserved in bacteria
HC680_23330	COG1194	a g-specific adenine glycosylase
HC680_23345	COG2211	Major facilitator Superfamily
HC680_23350	COG1982	Orn Lys Arg decarboxylase major
HC680_23355	COG1811	Na channel or pump
HC680_23385	COG3188	usher protein
HC680_23390	COG3121	Chaperone
HC680_23395	COG3121	Chaperone
HC680_23410	COG3121	Chaperone
HC680_23425	COG0626	cystathionine gamma-synthase activity
HC680_23430	COG0583	DNA-binding transcription factor activity
HC680_23450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC680_23455	COG0754	glutathionylspermidine amidase activity
HC680_23470	COG0625	glutathione transferase activity
HC680_23490	COG0848	biopolymer transport protein
HC680_23505	COG0626	cystathionine gamma-synthase activity
HC680_23510	COG0586	Pfam SNARE associated Golgi protein
HC680_23515	COG2207	Transcriptional regulator
HC680_23520	COG1979	alcohol dehydrogenase
HC680_23525	COG0656	L-ascorbic acid biosynthetic process
HC680_23535	COG1032	radical SAM domain protein
HC680_23540	COG2132	Multicopper oxidase
HC680_23545	COG0204	Acyl-transferase
HC680_23550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC680_23555	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HC680_23560	COG3111	PFAM Bacterial OB fold (BOF) protein
HC680_23570	COG0642	Histidine kinase
HC680_23575	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC680_23580	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC680_23590	COG3150	esterase
HC680_23595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HC680_23600	COG3151	Protein conserved in bacteria
HC680_23605	COG0494	nUDIX hydrolase
HC680_23620	COG0754	glutathionylspermidine amidase activity
HC680_23625	COG3384	dioxygenase
HC680_23640	COG2960	long-chain fatty acid transporting porin activity
HC680_23665	COG3025	triphosphatase activity
HC680_23670	COG4991	sh3 domain protein
HC680_23685	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HC680_23750	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HC680_23755	COG0358	DNA primase activity
HC680_23760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC680_23785	COG2197	response regulator
HC680_23790	COG2198	Histidine kinase
HC680_23790	COG0784	Response regulator, receiver
HC680_23790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC680_23790	COG2205	protein histidine kinase activity
HC680_23800	COG3247	response to pH
HC680_23870	COG2376	Dihydroxyacetone kinase
HC680_23875	COG1461	Dihydroxyacetone kinase
HC680_23890	COG2375	cellular response to nickel ion
HC680_23900	COG1695	Transcriptional regulator
HC680_23950	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC680_23950	COG1902	pentaerythritol trinitrate reductase activity
HC680_23970	COG1451	nucleotide metabolic process
HC680_23975	COG0673	inositol 2-dehydrogenase activity
HC680_23980	COG0861	Integral membrane protein TerC family
HC680_23995	COG2721	sulfolactate sulfo-lyase activity
HC680_24005	COG2271	Major facilitator Superfamily
HC680_24010	COG2186	Transcriptional regulator
HC680_24015	COG0586	Pfam SNARE associated Golgi protein
HC680_24025	COG1422	Protein of unknown function (DUF1090)
HC680_24030	COG4575	ribosome binding
HC680_24035	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HC680_24045	COG2259	Doxx family
HC680_24050	COG0435	Glutathione S-transferase
HC680_24055	COG3152	Membrane
HC680_24060	COG0583	DNA-binding transcription factor activity
HC680_24065	COG1741	Belongs to the pirin family
HC680_24095	COG1929	Belongs to the glycerate kinase type-1 family
HC680_24100	COG2084	Dehydrogenase
HC680_24110	COG2271	Major facilitator Superfamily
HC680_24120	COG2721	sulfolactate sulfo-lyase activity
HC680_24125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC680_24130	COG1349	DNA-binding transcription factor activity
HC680_24145	COG1105	Belongs to the carbohydrate kinase PfkB family
HC680_24150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_24150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC680_24150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC680_24155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_24155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_24165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_24170	COG3414	Phosphotransferase system galactitol-specific IIB component
HC680_24175	COG3775	system Galactitol-specific IIC component
HC680_24180	COG1063	alcohol dehydrogenase
HC680_24195	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HC680_24215	COG2823	Periplasmic or secreted lipoprotein
HC680_24220	COG0701	Predicted permease
HC680_24225	COG0702	epimerase
HC680_24230	COG0693	protein deglycase activity
HC680_24245	COG3153	acetyltransferase
HC680_24250	COG3154	lipid carrier protein
HC680_24255	COG0826	peptidase U32
HC680_24260	COG0826	peptidase U32
HC680_24265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC680_24270	COG0814	amino acid
HC680_24315	COG0195	Participates in both transcription termination and antitermination
HC680_24360	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC680_24370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HC680_24375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC680_24385	COG1534	Rna-binding protein
HC680_24395	COG2027	D-alanyl-D-alanine carboxypeptidase
HC680_24405	COG0697	spore germination
HC680_24420	COG0142	geranyltranstransferase activity
HC680_24425	COG3423	Transcriptional regulator
HC680_24435	COG5007	Belongs to the BolA IbaG family
HC680_24440	COG3113	response to antibiotic
HC680_24445	COG2854	intermembrane phospholipid transfer
HC680_24450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HC680_24455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HC680_24460	COG1127	ABC transporter
HC680_24465	COG0530	calcium, potassium:sodium antiporter activity
HC680_24475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HC680_24480	COG3117	lipopolysaccharide transmembrane transporter activity
HC680_24485	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HC680_24490	COG1137	ATPase activity
HC680_24495	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HC680_24500	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HC680_24505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_24515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC680_24520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC680_24525	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HC680_24530	COG2198	Histidine kinase
HC680_24530	COG5002	protein histidine kinase activity
HC680_24530	COG0784	Response regulator, receiver
HC680_24535	COG1312	Catalyzes the dehydration of D-mannonate
HC680_24545	COG1063	alcohol dehydrogenase
HC680_24550	COG2271	Major facilitator Superfamily
HC680_24555	COG1242	4 iron, 4 sulfur cluster binding
HC680_24560	COG0067	glutamate synthase
HC680_24560	COG0070	glutamate synthase
HC680_24560	COG0069	glutamate synthase activity
HC680_24565	COG0493	'glutamate synthase
HC680_24575	COG2969	positive regulation of protein catabolic process
HC680_24580	COG0625	glutathione transferase activity
HC680_24600	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HC680_24605	COG3105	Protein conserved in bacteria
HC680_24610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC680_24615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC680_24640	COG2732	(Barnase) inhibitor
HC680_24645	COG1289	transmembrane transporter activity
HC680_24660	COG0583	DNA-binding transcription factor activity
HC680_24665	COG0312	modulator of DNA gyrase
HC680_24670	COG3164	Protein of unknown function
HC680_24675	COG1530	ribonuclease E activity
HC680_24685	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HC680_24690	COG1792	Involved in formation and maintenance of cell shape
HC680_24695	COG1077	Cell shape determining protein MreB Mrl
HC680_24700	COG2199	diguanylate cyclase activity
HC680_24700	COG2200	EAL domain
HC680_24725	COG0511	ligase activity, forming carbon-carbon bonds
HC680_24730	COG0439	Biotin carboxylase
HC680_24735	COG3924	membrane
HC680_24740	COG4145	pantothenate transmembrane transporter activity
HC680_24760	COG1309	transcriptional regulator
HC680_24765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC680_24770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC680_24815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HC680_24845	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HC680_24855	COG1739	Uncharacterized protein family UPF0029
HC680_24900	COG0805	protein transport
HC680_24920	COG3165	ubiquinone biosynthetic process from chorismate
HC680_24950	COG0583	DNA-binding transcription factor activity
HC680_24955	COG0697	spore germination
HC680_24960	COG0561	phosphatase activity
HC680_24965	COG2267	carboxylic ester hydrolase activity
HC680_24970	COG1280	lysine exporter protein (LysE YggA)
HC680_24980	COG1280	lysine exporter protein (LysE YggA)
HC680_25010	COG0210	DNA helicase
HC680_25015	COG1011	Hydrolase
HC680_25045	COG3072	Adenylate cyclase
HC680_25060	COG2959	enzyme of heme biosynthesis
HC680_25065	COG3071	HemY protein
HC680_25115	COG2244	polysaccharide biosynthetic process
HC680_25120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC680_25125	COG0456	acetyltransferase
HC680_25130	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HC680_25135	COG1088	dTDP-glucose 4,6-dehydratase activity
HC680_25140	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HC680_25145	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HC680_25155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC680_25160	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HC680_25165	COG3118	belongs to the thioredoxin family
HC680_25190	COG1811	Na channel or pump
HC680_25200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC680_25205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC680_25215	COG0583	DNA-binding transcription factor activity
HC680_25220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC680_25235	COG3978	acetolactate synthase activity
HC680_25255	COG3085	chromosome segregation
HC680_25330	COG0583	DNA-binding transcription factor activity
HC680_25345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HC680_25360	COG3443	Belongs to the bacterial solute-binding protein 9 family
HC680_25365	COG2207	Transcriptional regulator
HC680_25375	COG0371	Dehydrogenase
HC680_25380	COG0697	spore germination
HC680_25390	COG0583	DNA-binding transcription factor activity
HC680_25400	COG0737	Belongs to the 5'-nucleotidase family
HC680_25410	COG0527	aspartate kinase activity
HC680_25410	COG0460	homoserine dehydrogenase
HC680_25415	COG0626	cystathionine gamma-synthase activity
HC680_25430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC680_25435	COG1609	Transcriptional regulator
HC680_25440	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HC680_25455	COG1575	Belongs to the MenA family. Type 1 subfamily
HC680_25475	COG3678	ATP-independent chaperone mediated protein folding
HC680_25480	COG0745	RESPONSE REGULATOR receiver
HC680_25485	COG2205	protein histidine kinase activity
HC680_25490	COG2258	MOSC domain
HC680_25495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC680_25535	COG1129	ABC transporter
HC680_25540	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC680_25545	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC680_25550	COG1454	alcohol dehydrogenase
HC680_25560	COG2211	Major facilitator Superfamily
HC680_25620	COG0205	6-phosphofructokinase activity
HC680_25640	COG0437	4 iron, 4 sulfur cluster binding
HC680_25645	COG2864	formate dehydrogenase
HC680_25660	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HC680_25670	COG0456	acetyltransferase
HC680_25685	COG1011	Hydrolase
HC680_25700	COG3852	Histidine kinase
HC680_25715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC680_25735	COG0204	Acyl-transferase
HC680_25745	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC680_25750	COG3084	Protein conserved in bacteria
HC680_25760	COG1763	Mo-molybdopterin cofactor biosynthetic process
HC680_25785	COG2186	Transcriptional regulator
HC680_25790	COG0477	Major facilitator Superfamily
HC680_25795	COG1609	Transcriptional regulator
HC680_25800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC680_25810	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC680_25815	COG1129	ABC transporter
HC680_25845	COG1522	sequence-specific DNA binding
HC680_25850	COG0716	FMN binding
HC680_25865	COG3312	ion transport
HC680_25930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC680_25935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC680_25940	COG0573	inorganic phosphate transmembrane transporter activity
HC680_25945	COG0581	inorganic phosphate transmembrane transporter activity
HC680_25950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC680_25955	COG0704	Plays a role in the regulation of phosphate uptake
HC680_25970	COG2382	esterase
HC680_25975	COG0363	glucosamine-6-phosphate deaminase activity
HC680_25980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC680_25990	COG2252	PERMEase
HC680_25995	COG0431	NADPH-dependent FMN reductase
HC680_26000	COG2091	lysine biosynthetic process via aminoadipic acid
HC680_26030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HC680_26170	COG1199	ATP-dependent helicase activity
HC680_26310	COG5654	RES domain protein
HC680_26315	COG5642	Protein of unknown function (DUF2384)
HC680_26365	COG1192	Involved in chromosome partitioning
HC680_26420	COG0305	Participates in initiation and elongation during chromosome replication
HC680_26575	COG3039	Transposase
HC680_26615	COG3220	belongs to the UPF0276 family
HC680_26640	COG4134	Bacterial extracellular solute-binding protein
HC680_26645	COG4135	transport system, permease component
HC680_26650	COG4136	ATPase activity
HC680_26655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HC680_26690	COG0589	response to stress
HC680_26695	COG0659	secondary active sulfate transmembrane transporter activity
HC680_26725	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HC680_26745	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HC680_26755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC680_26800	COG0789	Transcriptional regulator
HC680_26825	COG3344	reverse transcriptase
HC680_27005	COG1028	Short-chain dehydrogenase reductase Sdr
HC680_27095	COG1192	Involved in chromosome partitioning
HC680_27115	COG1522	sequence-specific DNA binding
HC680_27120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HC680_27130	COG0789	Transcriptional regulator
HC680_27150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC680_27155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC680_27170	COG3423	Transcriptional regulator
HC680_27330	COG2974	May be involved in recombination
HC680_27365	COG3039	Transposase
HC680_27385	COG3272	Protein of unknown function (DUF1722)
HC680_27390	COG4580	involved in the transport of maltose and maltodextrins
HC680_27400	COG2223	nitrite transmembrane transporter activity
HC680_27410	COG1609	Transcriptional regulator
HC680_27425	COG3039	Transposase
HC680_27450	COG3039	Transposase
HC680_27455	COG1802	Transcriptional regulator
HC680_27475	COG2826	transposase and inactivated derivatives, IS30 family
HC680_27480	COG2963	transposase activity
HC680_27565	COG0038	chloride channel
HC680_27570	COG0671	phosphoesterase, PA-phosphatase related
HC680_27575	COG1227	inorganic diphosphatase activity
HC680_27585	COG0148	phosphopyruvate hydratase activity
HC680_27595	COG0588	phosphoglycerate mutase activity
HC680_27600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC680_27605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC680_27610	COG1193	negative regulation of DNA recombination
HC680_27615	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HC680_27630	COG3344	reverse transcriptase
HC680_27655	COG2826	transposase and inactivated derivatives, IS30 family
HC680_27665	COG3344	reverse transcriptase
HC680_27700	COG3039	Transposase
HC680_27755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC680_27770	COG0210	DNA helicase
HC680_27810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HC680_27810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HC680_28000	COG5499	transcription regulator containing HTH domain
HC680_28005	COG4680	protein conserved in bacteria
HC680_28020	COG3436	PFAM IS66 Orf2 family protein
HC680_28025	COG4372	Transposase
HC680_28035	COG3039	Transposase
HC680_28045	COG4598	ABC transporter
HC680_28070	COG0583	DNA-binding transcription factor activity
HC680_28100	COG5654	RES domain protein
HC680_28105	COG5642	Protein of unknown function (DUF2384)
HC680_28135	COG3436	PFAM IS66 Orf2 family protein
HC680_28155	COG0501	Belongs to the peptidase M48B family
HC680_28165	COG3706	GGDEF domain
HC680_28175	COG0542	response to heat
HC680_28180	COG0071	Belongs to the small heat shock protein (HSP20) family
HC680_28225	COG3436	PFAM IS66 Orf2 family protein
HC680_28245	COG2205	protein histidine kinase activity
HC680_28250	COG0745	RESPONSE REGULATOR receiver
HC680_28255	COG1276	copper resistance
HC680_28260	COG2372	response to copper ion
HC680_28265	COG3667	copper resistance
HC680_28270	COG2132	Multicopper oxidase
HC680_28280	COG0739	heme binding
HC680_28310	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC680_28360	COG3547	Transposase (IS116 IS110 IS902 family)
HC680_28415	COG0840	transmembrane signaling receptor activity
HC680_28430	COG1349	DNA-binding transcription factor activity
HC680_28435	COG2084	Dehydrogenase
HC680_28465	COG3344	reverse transcriptase
HC680_28565	COG1136	(ABC) transporter
HC680_28565	COG0577	efflux transmembrane transporter activity
HC680_28575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HC680_28590	COG4372	Transposase
HC680_28595	COG3436	PFAM IS66 Orf2 family protein
HC680_28695	COG2372	response to copper ion
HC680_28705	COG3039	Transposase
HC680_28715	COG2814	Major facilitator Superfamily
HC680_28720	COG0543	2 iron, 2 sulfur cluster binding
HC680_28735	COG0418	dihydroorotase activity
HC680_28765	COG2223	nitrite transmembrane transporter activity
HC680_28775	COG1609	Transcriptional regulator
HC680_28800	COG3436	PFAM IS66 Orf2 family protein
HC680_28805	COG1120	ATPase activity
HC680_28810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC680_28815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC680_28820	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC680_28825	COG4772	TonB-dependent receptor
HC680_28830	COG3712	iron ion homeostasis
HC680_28835	COG1595	DNA-templated transcription, initiation
HC680_28865	COG2223	nitrite transmembrane transporter activity
HC680_28875	COG1609	Transcriptional regulator
HC680_28885	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
HC680_29040	COG2801	Transposase and inactivated derivatives
HC680_29070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC680_29080	COG2801	Transposase and inactivated derivatives
HC680_29140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC680_29145	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HC680_29175	COG2986	histidine ammonia-lyase
HC680_29185	COG2188	Transcriptional regulator
HC680_29190	COG0402	S-adenosylhomocysteine deaminase activity
HC680_29365	COG0629	single-stranded DNA binding
HC680_29700	COG4644	lycopene metabolic process
HC680_29720	COG4763	Acyl-transferase
HC680_29775	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC680_29865	COG0058	SHG alpha-glucan phosphorylase activity
HC680_29870	COG0033	Phosphoglucomutase
HC680_29890	COG2801	Transposase and inactivated derivatives
HC680_29900	COG2801	Transposase and inactivated derivatives
HC680_29910	COG2801	Transposase and inactivated derivatives
HC680_29955	COG5290	Psort location Cytoplasmic, score
HC680_29975	COG4644	lycopene metabolic process