locus-tag	class	description
C2L60_00020	COG0187	DNA topoisomerase II activity
C2L60_00025	COG0561	phosphatase activity
C2L60_00040	COG2186	Transcriptional regulator
C2L60_00045	COG3734	2-keto-3-deoxy-galactonokinase
C2L60_00050	COG0800	Aldolase
C2L60_00060	COG3039	Transposase
C2L60_00070	COG3039	Transposase
C2L60_00080	COG2271	Major facilitator Superfamily
C2L60_00085	COG0823	Involved in the tonB-independent uptake of proteins
C2L60_00090	COG5645	(Lipo)protein
C2L60_00105	COG3645	SOS response
C2L60_00115	COG2188	Transcriptional regulator
C2L60_00130	COG2149	membrane
C2L60_00150	COG2610	gluconate transmembrane transporter activity
C2L60_00155	COG0583	DNA-binding transcription factor activity
C2L60_00160	COG2814	Major facilitator Superfamily
C2L60_00185	COG0028	Belongs to the TPP enzyme family
C2L60_00190	COG0440	acetolactate synthase activity
C2L60_00195	COG2197	response regulator
C2L60_00205	COG2271	Major facilitator Superfamily
C2L60_00250	COG2188	Transcriptional regulator
C2L60_00280	COG4580	involved in the transport of maltose and maltodextrins
C2L60_00285	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2L60_00290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2L60_00290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2L60_00300	COG1609	Transcriptional regulator
C2L60_00310	COG3384	dioxygenase
C2L60_00315	COG0583	DNA-binding transcription factor activity
C2L60_00320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2L60_00325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2L60_00330	COG2828	Protein conserved in bacteria
C2L60_00345	COG0697	spore germination
C2L60_00350	COG1263	PTS System
C2L60_00350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2L60_00360	COG2814	Major facilitator Superfamily
C2L60_00365	COG1538	Outer membrane efflux protein
C2L60_00370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L60_00405	COG0583	DNA-binding transcription factor activity
C2L60_00430	COG1464	Belongs to the NlpA lipoprotein family
C2L60_00445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2L60_00455	COG1064	alcohol dehydrogenase
C2L60_00490	COG2211	Major facilitator Superfamily
C2L60_00495	COG1501	Belongs to the glycosyl hydrolase 31 family
C2L60_00505	COG1486	melibiose metabolic process
C2L60_00510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2L60_00510	COG1263	PTS System
C2L60_00515	COG2982	Protein involved in outer membrane biogenesis
C2L60_00520	COG2233	PERMEase
C2L60_00525	COG0786	glutamate:sodium symporter activity
C2L60_00545	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2L60_00570	COG3152	Membrane
C2L60_00580	COG1494	fructose-1,6-bisphosphatase
C2L60_00585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2L60_00590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2L60_00595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2L60_00615	COG2860	membrane
C2L60_00625	COG2169	Transcriptional regulator
C2L60_00625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2L60_00630	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2L60_00635	COG1561	YicC-like family, N-terminal region
C2L60_00640	COG3039	Transposase
C2L60_00650	COG3039	Transposase
C2L60_00665	COG1131	(ABC) transporter
C2L60_00670	COG0842	Transport permease protein
C2L60_00695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2L60_00730	COG1519	Transferase
C2L60_00735	COG1216	Glycosyl transferase, family 2
C2L60_00740	COG0438	transferase activity, transferring glycosyl groups
C2L60_00750	COG0859	PFAM glycosyl transferase family 9
C2L60_00775	COG0859	PFAM glycosyl transferase family 9
C2L60_00790	COG0156	8-amino-7-oxononanoate synthase activity
C2L60_00800	COG0463	Glycosyl transferase, family 2
C2L60_00805	COG2861	carbohydrate metabolic process
C2L60_00810	COG4942	peptidase
C2L60_00820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2L60_00825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2L60_00845	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2L60_00855	COG2186	Transcriptional regulator
C2L60_00875	COG3722	fumarate hydratase activity
C2L60_00895	COG1566	PFAM secretion protein HlyD family protein
C2L60_00900	COG0625	glutathione transferase activity
C2L60_00910	COG3276	selenocysteine insertion sequence binding
C2L60_00915	COG1414	Transcriptional regulator
C2L60_00920	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2L60_00925	COG3977	Valine--pyruvate aminotransferase
C2L60_00930	COG0366	Alpha amylase catalytic
C2L60_00940	COG2992	FlgJ-related protein
C2L60_00945	COG2207	Transcriptional regulator
C2L60_00945	COG1609	Transcriptional regulator
C2L60_00950	COG4214	carbohydrate transport
C2L60_00955	COG1129	ABC transporter
C2L60_00960	COG4213	ABC transporter substrate-binding protein
C2L60_00980	COG4682	membrane
C2L60_00985	COG4682	membrane
C2L60_00990	COG3274	enterobacterial common antigen metabolic process
C2L60_01030	COG1278	Cold shock
C2L60_01035	COG2944	sequence-specific DNA binding
C2L60_01040	COG2814	Major facilitator Superfamily
C2L60_01065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2L60_01075	COG1609	Transcriptional regulator
C2L60_01080	COG2885	chlorophyll binding
C2L60_01085	COG0243	molybdopterin cofactor binding
C2L60_01090	COG0456	acetyltransferase
C2L60_01095	COG2818	Glycosylase
C2L60_01100	COG5571	outer membrane autotransporter
C2L60_01105	COG2223	nitrite transmembrane transporter activity
C2L60_01145	COG0747	negative chemotaxis
C2L60_01150	COG0601	transmembrane transport
C2L60_01155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2L60_01160	COG0444	Belongs to the ABC transporter superfamily
C2L60_01165	COG4608	Belongs to the ABC transporter superfamily
C2L60_01190	COG1215	transferase activity, transferring glycosyl groups
C2L60_01195	COG0457	Tetratricopeptide repeat
C2L60_01210	COG2194	sulfuric ester hydrolase activity
C2L60_01240	COG1215	transferase activity, transferring glycosyl groups
C2L60_01245	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2L60_01250	COG0457	Tetratricopeptide repeat
C2L60_01250	COG3118	belongs to the thioredoxin family
C2L60_01255	COG2200	EAL domain
C2L60_01255	COG2199	diguanylate cyclase activity
C2L60_01270	COG0612	Peptidase, M16
C2L60_01285	COG2982	Protein involved in outer membrane biogenesis
C2L60_01290	COG0477	Major facilitator Superfamily
C2L60_01295	COG1295	ribonuclease BN
C2L60_01300	COG0583	DNA-binding transcription factor activity
C2L60_01305	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_01310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2L60_01320	COG1454	alcohol dehydrogenase
C2L60_01330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2L60_01335	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2L60_01340	COG0671	phosphoesterase, PA-phosphatase related
C2L60_01360	COG0589	response to stress
C2L60_01370	COG0306	phosphate transporter
C2L60_01375	COG2081	HI0933 family
C2L60_01380	COG2239	Acts as a magnesium transporter
C2L60_01390	COG1124	(ABC) transporter
C2L60_01400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2L60_01405	COG0601	transmembrane transport
C2L60_01410	COG0747	negative chemotaxis
C2L60_01425	COG3479	Phenolic acid decarboxylase
C2L60_01465	COG0628	permease
C2L60_01470	COG0477	Major facilitator Superfamily
C2L60_01480	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2L60_01495	COG3714	YhhN family
C2L60_01505	COG3776	membrane
C2L60_01510	COG0742	ribosomal rna small subunit methyltransferase
C2L60_01515	COG0552	protein localization to endoplasmic reticulum
C2L60_01520	COG2884	Cell division ATP-binding protein ftsE
C2L60_01525	COG2177	Part of the ABC transporter FtsEX involved in
C2L60_01540	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2L60_01550	COG0683	leucine binding
C2L60_01570	COG0683	leucine binding
C2L60_01575	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2L60_01585	COG0411	ABC transporter
C2L60_01590	COG0410	ABC transporter
C2L60_01605	COG1653	transport
C2L60_01625	COG0584	glycerophosphoryl diester phosphodiesterase
C2L60_01635	COG0405	Gamma-glutamyltransferase
C2L60_01640	COG1247	-acetyltransferase
C2L60_01650	COG0673	inositol 2-dehydrogenase activity
C2L60_01655	COG1741	Belongs to the pirin family
C2L60_01660	COG1609	Transcriptional regulator
C2L60_01665	COG3265	gluconokinase activity
C2L60_01670	COG2610	gluconate transmembrane transporter activity
C2L60_01680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2L60_01705	COG0058	SHG alpha-glucan phosphorylase activity
C2L60_01720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2L60_01735	COG1349	DNA-binding transcription factor activity
C2L60_01750	COG0058	SHG alpha-glucan phosphorylase activity
C2L60_01755	COG1640	4-alpha-glucanotransferase
C2L60_01760	COG2610	gluconate transmembrane transporter activity
C2L60_01770	COG1040	competence protein
C2L60_01795	COG1918	ferrous iron import across plasma membrane
C2L60_01800	COG2183	response to ionizing radiation
C2L60_01805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2L60_01810	COG0745	RESPONSE REGULATOR receiver
C2L60_01830	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2L60_01835	COG1011	Hydrolase
C2L60_01845	COG0494	nUDIX hydrolase
C2L60_01850	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2L60_01875	COG4796	Type ii and iii secretion system protein
C2L60_01895	COG3266	domain, Protein
C2L60_01900	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2L60_01905	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2L60_01925	COG2146	nitrite reductase [NAD(P)H] activity
C2L60_01930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2L60_01935	COG0402	S-adenosylhomocysteine deaminase activity
C2L60_01940	COG0738	Major facilitator superfamily
C2L60_01965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2L60_01970	COG1289	transmembrane transporter activity
C2L60_01985	COG1765	OsmC-like protein
C2L60_01990	COG3954	Phosphoribulokinase
C2L60_02000	COG0429	hydrolase of the alpha beta-hydrolase fold
C2L60_02010	COG0488	(ABC) transporter
C2L60_02030	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2L60_02035	COG1047	Peptidyl-prolyl cis-trans
C2L60_02045	COG0545	Peptidyl-prolyl cis-trans isomerase
C2L60_02050	COG2964	Protein conserved in bacteria
C2L60_02095	COG2906	2 iron, 2 sulfur cluster binding
C2L60_02110	COG0051	transcription antitermination factor activity, RNA binding
C2L60_02145	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2L60_02150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2L60_02215	COG0201	protein transport
C2L60_02240	COG0202	RNA polymerase activity
C2L60_02255	COG0789	Transcriptional regulator
C2L60_02260	COG3036	rescue of stalled ribosome
C2L60_02270	COG0569	domain protein
C2L60_02290	COG0758	DNA mediated transformation
C2L60_02300	COG0551	DNA topoisomerase type I activity
C2L60_02320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2L60_02360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L60_02365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L60_02370	COG1309	transcriptional regulator
C2L60_02375	COG0582	viral genome integration into host DNA
C2L60_02390	COG3561	AntA/AntB antirepressor
C2L60_02480	COG1802	Transcriptional regulator
C2L60_02480	COG4626	Terminase
C2L60_02510	COG4145	pantothenate transmembrane transporter activity
C2L60_02515	COG3924	membrane
C2L60_02520	COG0439	Biotin carboxylase
C2L60_02525	COG0511	ligase activity, forming carbon-carbon bonds
C2L60_02545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2L60_02555	COG2200	EAL domain
C2L60_02555	COG2199	diguanylate cyclase activity
C2L60_02565	COG1077	Cell shape determining protein MreB Mrl
C2L60_02570	COG1792	Involved in formation and maintenance of cell shape
C2L60_02575	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2L60_02585	COG1530	ribonuclease E activity
C2L60_02590	COG3164	Protein of unknown function
C2L60_02595	COG0312	modulator of DNA gyrase
C2L60_02600	COG0583	DNA-binding transcription factor activity
C2L60_02615	COG1289	transmembrane transporter activity
C2L60_02620	COG2732	(Barnase) inhibitor
C2L60_02645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2L60_02650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2L60_02655	COG3105	Protein conserved in bacteria
C2L60_02660	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2L60_02680	COG0625	glutathione transferase activity
C2L60_02685	COG2969	positive regulation of protein catabolic process
C2L60_02695	COG0493	'glutamate synthase
C2L60_02700	COG0070	glutamate synthase
C2L60_02700	COG0069	glutamate synthase activity
C2L60_02700	COG0067	glutamate synthase
C2L60_02710	COG1242	4 iron, 4 sulfur cluster binding
C2L60_02715	COG2271	Major facilitator Superfamily
C2L60_02720	COG1063	alcohol dehydrogenase
C2L60_02725	COG1312	Catalyzes the dehydration of D-mannonate
C2L60_02730	COG5002	protein histidine kinase activity
C2L60_02730	COG0784	Response regulator, receiver
C2L60_02730	COG2198	Histidine kinase
C2L60_02735	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2L60_02740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2L60_02745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_02755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_02760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2L60_02765	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2L60_02770	COG1137	ATPase activity
C2L60_02775	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2L60_02780	COG3117	lipopolysaccharide transmembrane transporter activity
C2L60_02785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2L60_02795	COG0530	calcium, potassium:sodium antiporter activity
C2L60_02805	COG1127	ABC transporter
C2L60_02810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2L60_02815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2L60_02820	COG2854	intermembrane phospholipid transfer
C2L60_02825	COG3113	response to antibiotic
C2L60_02830	COG5007	Belongs to the BolA IbaG family
C2L60_02840	COG3423	Transcriptional regulator
C2L60_02845	COG0142	geranyltranstransferase activity
C2L60_02860	COG0697	spore germination
C2L60_02870	COG2027	D-alanyl-D-alanine carboxypeptidase
C2L60_02875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2L60_02880	COG1534	Rna-binding protein
C2L60_02890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2L60_02895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2L60_02905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2L60_02945	COG0195	Participates in both transcription termination and antitermination
C2L60_02995	COG0814	amino acid
C2L60_03000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L60_03020	COG3153	acetyltransferase
C2L60_03035	COG0693	protein deglycase activity
C2L60_03040	COG0702	epimerase
C2L60_03045	COG0701	Predicted permease
C2L60_03050	COG2823	Periplasmic or secreted lipoprotein
C2L60_03070	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2L60_03085	COG1063	alcohol dehydrogenase
C2L60_03090	COG3775	system Galactitol-specific IIC component
C2L60_03095	COG3414	Phosphotransferase system galactitol-specific IIB component
C2L60_03100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_03110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_03110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_03115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2L60_03115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_03115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2L60_03120	COG1105	Belongs to the carbohydrate kinase PfkB family
C2L60_03130	COG1349	DNA-binding transcription factor activity
C2L60_03135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2L60_03140	COG2721	sulfolactate sulfo-lyase activity
C2L60_03145	COG2271	Major facilitator Superfamily
C2L60_03155	COG2084	Dehydrogenase
C2L60_03160	COG1929	Belongs to the glycerate kinase type-1 family
C2L60_03180	COG1741	Belongs to the pirin family
C2L60_03185	COG0583	DNA-binding transcription factor activity
C2L60_03190	COG3152	Membrane
C2L60_03195	COG0435	Glutathione S-transferase
C2L60_03200	COG2259	Doxx family
C2L60_03210	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
C2L60_03215	COG4575	ribosome binding
C2L60_03220	COG1422	Protein of unknown function (DUF1090)
C2L60_03230	COG0586	Pfam SNARE associated Golgi protein
C2L60_03235	COG2186	Transcriptional regulator
C2L60_03240	COG2271	Major facilitator Superfamily
C2L60_03250	COG2721	sulfolactate sulfo-lyase activity
C2L60_03265	COG0861	Integral membrane protein TerC family
C2L60_03270	COG0673	inositol 2-dehydrogenase activity
C2L60_03275	COG1451	nucleotide metabolic process
C2L60_03295	COG1902	pentaerythritol trinitrate reductase activity
C2L60_03295	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2L60_03350	COG1695	Transcriptional regulator
C2L60_03355	COG2375	cellular response to nickel ion
C2L60_03370	COG1461	Dihydroxyacetone kinase
C2L60_03375	COG2376	Dihydroxyacetone kinase
C2L60_03455	COG3247	response to pH
C2L60_03465	COG2205	protein histidine kinase activity
C2L60_03465	COG0784	Response regulator, receiver
C2L60_03465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L60_03465	COG2198	Histidine kinase
C2L60_03470	COG2197	response regulator
C2L60_03495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2L60_03500	COG0358	DNA primase activity
C2L60_03570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2L60_03585	COG4991	sh3 domain protein
C2L60_03590	COG3025	triphosphatase activity
C2L60_03610	COG2960	long-chain fatty acid transporting porin activity
C2L60_03625	COG3384	dioxygenase
C2L60_03630	COG0754	glutathionylspermidine amidase activity
C2L60_03645	COG0494	nUDIX hydrolase
C2L60_03650	COG3151	Protein conserved in bacteria
C2L60_03655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2L60_03660	COG3150	esterase
C2L60_03665	COG0187	DNA topoisomerase II activity
C2L60_03670	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2L60_03675	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2L60_03680	COG0642	Histidine kinase
C2L60_03685	COG0745	RESPONSE REGULATOR receiver
C2L60_03690	COG3111	PFAM Bacterial OB fold (BOF) protein
C2L60_03695	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C2L60_03700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2L60_03705	COG0204	Acyl-transferase
C2L60_03710	COG2132	Multicopper oxidase
C2L60_03715	COG1032	radical SAM domain protein
C2L60_03725	COG0656	L-ascorbic acid biosynthetic process
C2L60_03730	COG1979	alcohol dehydrogenase
C2L60_03735	COG2207	Transcriptional regulator
C2L60_03740	COG0586	Pfam SNARE associated Golgi protein
C2L60_03745	COG0626	cystathionine gamma-synthase activity
C2L60_03755	COG0811	peptide transport
C2L60_03760	COG0848	biopolymer transport protein
C2L60_03765	COG2211	Major facilitator Superfamily
C2L60_03790	COG0625	glutathione transferase activity
C2L60_03800	COG0754	glutathionylspermidine amidase activity
C2L60_03805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L60_03825	COG0583	DNA-binding transcription factor activity
C2L60_03830	COG0626	cystathionine gamma-synthase activity
C2L60_03880	COG0305	Participates in initiation and elongation during chromosome replication
C2L60_04095	COG3423	Transcriptional regulator
C2L60_04105	COG1278	Cold shock
C2L60_04110	COG3423	Transcriptional regulator
C2L60_04120	COG3039	Transposase
C2L60_04185	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2L60_04195	COG1811	Na channel or pump
C2L60_04205	COG1982	Orn Lys Arg decarboxylase major
C2L60_04210	COG2211	Major facilitator Superfamily
C2L60_04225	COG1194	a g-specific adenine glycosylase
C2L60_04235	COG3171	Protein conserved in bacteria
C2L60_04245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2L60_04260	COG0762	integral membrane protein
C2L60_04265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2L60_04270	COG2805	Type II/IV secretion system protein
C2L60_04290	COG0189	ligase activity
C2L60_04295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2L60_04300	COG2356	endonuclease I
C2L60_04310	COG2814	Major facilitator Superfamily
C2L60_04350	COG2146	nitrite reductase [NAD(P)H] activity
C2L60_04365	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_04370	COG1414	Transcriptional regulator
C2L60_04400	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_04405	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
C2L60_04430	COG3039	Transposase
C2L60_04435	COG0501	Belongs to the peptidase M48B family
C2L60_04440	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2L60_04455	COG0191	fructose-bisphosphate aldolase activity
C2L60_04460	COG0668	transmembrane transport
C2L60_04470	COG2968	Membrane
C2L60_04485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2L60_04490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2L60_04510	COG0006	proline dipeptidase activity
C2L60_04515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2L60_04520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2L60_04540	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_04545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2L60_04565	COG2723	6-phospho-beta-galactosidase activity
C2L60_04570	COG1737	Transcriptional regulator
C2L60_04580	COG1272	protein, Hemolysin III
C2L60_04590	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2L60_04600	COG0716	FMN binding
C2L60_04605	COG4974	Belongs to the 'phage' integrase family
C2L60_04615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2L60_04640	COG4942	peptidase
C2L60_04650	COG2814	Major facilitator Superfamily
C2L60_04665	COG0667	Aldo Keto reductase
C2L60_04700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2L60_04705	COG1393	Belongs to the ArsC family
C2L60_04710	COG3104	oligopeptide transport
C2L60_04720	COG1538	Outer membrane efflux protein
C2L60_04725	COG1289	transmembrane transporter activity
C2L60_04740	COG3592	Divergent 4Fe-4S mono-cluster
C2L60_04745	COG2388	GCN5-related N-acetyl-transferase
C2L60_04755	COG3539	Fimbrial protein
C2L60_04760	COG3539	Fimbrial protein
C2L60_04765	COG3539	Fimbrial protein
C2L60_04770	COG3188	usher protein
C2L60_04775	COG3121	Chaperone
C2L60_04780	COG3539	Fimbrial protein
C2L60_04790	COG4974	Belongs to the 'phage' integrase family
C2L60_04795	COG0582	viral genome integration into host DNA
C2L60_04805	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2L60_04810	COG1846	Transcriptional regulator
C2L60_04815	COG0697	spore germination
C2L60_04825	COG3039	Transposase
C2L60_04875	COG0667	Aldo Keto reductase
C2L60_04880	COG0814	amino acid
C2L60_04895	COG0183	Belongs to the thiolase family
C2L60_04900	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2L60_04905	COG0823	Involved in the tonB-independent uptake of proteins
C2L60_04910	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_04915	COG2814	Major facilitator Superfamily
C2L60_04945	COG3842	ATPase activity
C2L60_04950	COG0395	ABC-type sugar transport system, permease component
C2L60_04955	COG1175	transmembrane transport
C2L60_04960	COG1917	Cupin 2, conserved barrel domain protein
C2L60_04965	COG1794	racemase activity, acting on amino acids and derivatives
C2L60_04970	COG0583	DNA-binding transcription factor activity
C2L60_04975	COG0019	diaminopimelate decarboxylase activity
C2L60_04980	COG1609	Transcriptional regulator
C2L60_04985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2L60_04990	COG2723	6-phospho-beta-galactosidase activity
C2L60_04995	COG2186	Transcriptional regulator
C2L60_05005	COG1609	Transcriptional regulator
C2L60_05030	COG0667	Aldo Keto reductase
C2L60_05040	COG0861	Integral membrane protein TerC family
C2L60_05070	COG2165	general secretion pathway protein
C2L60_05075	COG4795	General secretion pathway protein
C2L60_05085	COG4967	type IV pilus modification protein PilV
C2L60_05090	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2L60_05095	COG1025	Belongs to the peptidase M16 family
C2L60_05100	COG1074	ATP-dependent DNA helicase activity
C2L60_05105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2L60_05115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2L60_05115	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2L60_05120	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2L60_05125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2L60_05145	COG4810	utilization protein
C2L60_05155	COG4656	Part of a membrane complex involved in electron transport
C2L60_05160	COG1454	alcohol dehydrogenase
C2L60_05160	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_05195	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C2L60_05230	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C2L60_05265	COG2241	protein methyltransferase activity
C2L60_05275	COG2875	Belongs to the precorrin methyltransferase family
C2L60_05355	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2L60_05360	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2L60_05365	COG2166	iron-sulfur cluster assembly
C2L60_05370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2L60_05380	COG0583	DNA-binding transcription factor activity
C2L60_05385	COG2363	Small membrane protein
C2L60_05395	COG1349	DNA-binding transcription factor activity
C2L60_05415	COG0738	Major facilitator superfamily
C2L60_05420	COG0235	Class ii aldolase
C2L60_05425	COG1454	alcohol dehydrogenase
C2L60_05440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L60_05455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2L60_05460	COG2011	ABC-type metal ion transport system permease component
C2L60_05465	COG1464	Belongs to the NlpA lipoprotein family
C2L60_05475	COG0477	Major facilitator Superfamily
C2L60_05485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L60_05490	COG1760	l-serine dehydratase
C2L60_05495	COG0814	amino acid
C2L60_05500	COG1611	Belongs to the LOG family
C2L60_05515	COG3098	single-species biofilm formation
C2L60_05520	COG0564	pseudouridine synthase activity
C2L60_05525	COG0716	FMN binding
C2L60_05530	COG2271	Major facilitator Superfamily
C2L60_05535	COG4948	Mandelate Racemase Muconate Lactonizing
C2L60_05540	COG4948	Mandelate Racemase Muconate Lactonizing
C2L60_05545	COG1929	Belongs to the glycerate kinase type-1 family
C2L60_05550	COG2205	protein histidine kinase activity
C2L60_05550	COG4999	Histidine kinase
C2L60_05550	COG3437	response regulator, receiver
C2L60_05550	COG3850	Histidine kinase
C2L60_05560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2L60_05565	COG3956	TIGRFAM MazG family protein
C2L60_05585	COG0602	queuosine metabolic process
C2L60_05590	COG0720	synthase
C2L60_05610	COG2234	aminopeptidase activity
C2L60_05670	COG4942	peptidase
C2L60_05670	COG1388	LysM domain
C2L60_05675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2L60_05700	COG0163	prenyltransferase activity
C2L60_05705	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2L60_05750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2L60_05755	COG4558	Periplasmic binding protein
C2L60_05760	COG3720	iron ion transport
C2L60_05780	COG0679	Auxin Efflux Carrier
C2L60_05795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2L60_05800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2L60_05805	COG1121	(ABC) transporter
C2L60_05810	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2L60_05815	COG1609	Transcriptional regulator
C2L60_05820	COG1940	carbohydrate kinase activity
C2L60_05825	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2L60_05830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2L60_05835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2L60_05840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2L60_05850	COG4580	involved in the transport of maltose and maltodextrins
C2L60_05860	COG2723	6-phospho-beta-galactosidase activity
C2L60_05870	COG0309	Hydrogenase expression formation protein (HypE)
C2L60_05875	COG0409	Hydrogenase expression formation protein
C2L60_05880	COG0298	carbon dioxide binding
C2L60_05885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C2L60_05905	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2L60_05910	COG0651	ATP synthesis coupled electron transport
C2L60_05915	COG0650	Formate hydrogenlyase subunit 4
C2L60_05920	COG3261	NADH dehydrogenase
C2L60_05920	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C2L60_05925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2L60_05930	COG3260	NADH ubiquinone oxidoreductase 20
C2L60_05940	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2L60_05950	COG2723	6-phospho-beta-galactosidase activity
C2L60_05955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2L60_05955	COG1263	PTS System
C2L60_05960	COG1609	Transcriptional regulator
C2L60_05965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2L60_05970	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2L60_05975	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C2L60_06005	COG1349	DNA-binding transcription factor activity
C2L60_06010	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_06015	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_06025	COG3732	PTS system glucitol sorbitol-specific
C2L60_06030	COG3730	PTS system glucitol sorbitol-specific
C2L60_06035	COG2951	lytic endotransglycosylase activity
C2L60_06045	COG1121	(ABC) transporter
C2L60_06050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2L60_06055	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2L60_06060	COG1546	Belongs to the CinA family
C2L60_06115	COG2823	Periplasmic or secreted lipoprotein
C2L60_06120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2L60_06125	COG1238	metal cluster binding
C2L60_06145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2L60_06150	COG2814	Major facilitator Superfamily
C2L60_06155	COG1566	PFAM secretion protein HlyD family protein
C2L60_06160	COG1846	Transcriptional regulator
C2L60_06170	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2L60_06180	COG4176	ABC-type proline glycine betaine transport system permease component
C2L60_06195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2L60_06205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2L60_06210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2L60_06215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L60_06220	COG4575	ribosome binding
C2L60_06245	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2L60_06260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2L60_06265	COG0640	Transcriptional regulator
C2L60_06275	COG0583	DNA-binding transcription factor activity
C2L60_06280	COG3284	Transcriptional regulator
C2L60_06285	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_06290	COG3539	Fimbrial protein
C2L60_06295	COG3121	Chaperone
C2L60_06315	COG3188	usher protein
C2L60_06325	COG3539	Fimbrial protein
C2L60_06330	COG2197	response regulator
C2L60_06345	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_06355	COG0235	Class ii aldolase
C2L60_06365	COG3039	Transposase
C2L60_06370	COG4974	Belongs to the 'phage' integrase family
C2L60_06405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2L60_06425	COG3344	reverse transcriptase
C2L60_06460	COG4695	Portal protein
C2L60_06625	COG2867	negative regulation of translational initiation
C2L60_06640	COG0497	DNA recombination
C2L60_06660	COG4536	flavin adenine dinucleotide binding
C2L60_06665	COG4137	Cytochrome C assembly protein
C2L60_06670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2L60_06705	COG2885	chlorophyll binding
C2L60_06710	COG2199	diguanylate cyclase activity
C2L60_06720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2L60_06725	COG1605	Chorismate mutase
C2L60_06725	COG0287	Prephenate dehydrogenase
C2L60_06735	COG0077	Prephenate dehydratase
C2L60_06735	COG1605	Chorismate mutase
C2L60_06745	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2L60_06750	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2L60_06755	COG0564	pseudouridine synthase activity
C2L60_06765	COG0542	response to heat
C2L60_06790	COG0477	Major facilitator Superfamily
C2L60_06795	COG5544	Lipoprotein
C2L60_06800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2L60_06815	COG3118	belongs to the thioredoxin family
C2L60_06820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2L60_06835	COG0513	Belongs to the DEAD box helicase family
C2L60_06845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2L60_06855	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2L60_06860	COG3026	antisigma factor binding
C2L60_06865	COG3086	response to oxidative stress
C2L60_06875	COG0681	Belongs to the peptidase S26 family
C2L60_06895	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2L60_06905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2L60_06910	COG1737	Transcriptional regulator
C2L60_06915	COG0560	Phosphoserine phosphatase
C2L60_06920	COG0590	tRNA wobble adenosine to inosine editing
C2L60_06930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2L60_06930	COG0047	phosphoribosylformylglycinamidine synthase activity
C2L60_06935	COG2205	protein histidine kinase activity
C2L60_06940	COG3170	Tfp pilus assembly protein FimV
C2L60_06945	COG2204	response regulator
C2L60_06950	COG0347	Belongs to the P(II) protein family
C2L60_06955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2L60_06955	COG1017	nitric oxide dioxygenase activity
C2L60_06970	COG2259	Doxx family
C2L60_06975	COG1940	carbohydrate kinase activity
C2L60_06980	COG0457	Tetratricopeptide repeat
C2L60_06985	COG2814	Major facilitator Superfamily
C2L60_06985	COG0477	Major facilitator Superfamily
C2L60_06990	COG2017	converts alpha-aldose to the beta-anomer
C2L60_06995	COG2814	Major facilitator Superfamily
C2L60_07000	COG3711	transcriptional antiterminator
C2L60_07005	COG3683	transport system, periplasmic component
C2L60_07010	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2L60_07040	COG0822	iron-sulfur transferase activity
C2L60_07060	COG0633	Ferredoxin
C2L60_07065	COG2975	iron-sulfur cluster assembly
C2L60_07085	COG2897	thiosulfate sulfurtransferase activity
C2L60_07090	COG2373	Large extracellular alpha-helical protein
C2L60_07095	COG4953	penicillin-binding protein 1C
C2L60_07130	COG2976	Protein conserved in bacteria
C2L60_07150	COG1645	bacterial-type flagellum-dependent swarming motility
C2L60_07160	COG0517	IMP dehydrogenase activity
C2L60_07160	COG0516	GMP reductase activity
C2L60_07210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2L60_07290	COG3344	reverse transcriptase
C2L60_07305	COG3728	DNA packaging
C2L60_07305	COG5484	DNA packaging
C2L60_07440	COG3039	Transposase
C2L60_07480	COG3179	chitinase
C2L60_07495	COG0641	radical SAM
C2L60_07515	COG2200	EAL domain
C2L60_07520	COG0248	Ppx GppA phosphatase
C2L60_07530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2L60_07545	COG2723	6-phospho-beta-galactosidase activity
C2L60_07555	COG2233	PERMEase
C2L60_07570	COG1393	Belongs to the ArsC family
C2L60_07575	COG4783	chaperone-mediated protein folding
C2L60_07580	COG0628	permease
C2L60_07585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2L60_07590	COG2716	regulation of RNA biosynthetic process
C2L60_07600	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2L60_07610	COG2321	neutral zinc metallopeptidase
C2L60_07615	COG1444	tRNA N-acetyltransferase activity
C2L60_07620	COG0400	carboxylic ester hydrolase activity
C2L60_07635	COG1393	Belongs to the ArsC family
C2L60_07645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L60_07655	COG0493	'glutamate synthase
C2L60_07655	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2L60_07665	COG5342	invasion associated locus B
C2L60_07670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2L60_07675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2L60_07685	COG4810	utilization protein
C2L60_07690	COG4917	ethanolamine utilization protein
C2L60_07725	COG4820	ethanolamine utilization protein (EutJ)
C2L60_07755	COG4816	utilization protein
C2L60_07775	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2L60_07795	COG2837	iron assimilation
C2L60_07805	COG4150	thiosulfate binding
C2L60_07810	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2L60_07815	COG4208	sulfate ABC transporter
C2L60_07820	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2L60_07830	COG4319	ketosteroid isomerase
C2L60_07850	COG2190	(PTS) system
C2L60_07865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2L60_07885	COG3530	Putative quorum-sensing-regulated virulence factor
C2L60_07890	COG0385	Bile acid
C2L60_07895	COG0583	DNA-binding transcription factor activity
C2L60_07930	COG3415	Transposase
C2L60_07935	COG3415	Transposase
C2L60_07950	COG2200	EAL domain
C2L60_07950	COG2199	diguanylate cyclase activity
C2L60_07955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2L60_07970	COG0667	Aldo Keto reductase
C2L60_07975	COG3961	Belongs to the TPP enzyme family
C2L60_07990	COG3279	Response regulator of the LytR AlgR family
C2L60_07995	COG3275	phosphorelay sensor kinase activity
C2L60_08005	COG0436	Aminotransferase
C2L60_08015	COG2807	transmembrane transport
C2L60_08020	COG0590	tRNA wobble adenosine to inosine editing
C2L60_08025	COG0583	DNA-binding transcription factor activity
C2L60_08045	COG2116	formate transmembrane transporter activity
C2L60_08050	COG2853	Lipoprotein
C2L60_08065	COG3691	Protein conserved in bacteria
C2L60_08080	COG2062	phosphohistidine phosphatase, SixA
C2L60_08090	COG2890	protein-(glutamine-N5) methyltransferase activity
C2L60_08105	COG0730	response to heat
C2L60_08110	COG3101	peptidyl-lysine hydroxylation
C2L60_08125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2L60_08145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2L60_08155	COG0586	Pfam SNARE associated Golgi protein
C2L60_08165	COG0285	dihydrofolate synthase activity
C2L60_08170	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2L60_08175	COG1286	toxin biosynthetic process
C2L60_08180	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2L60_08185	COG0163	prenyltransferase activity
C2L60_08190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L60_08200	COG4215	(ABC) transporter
C2L60_08205	COG4160	amino acid transport
C2L60_08210	COG4598	ABC transporter
C2L60_08220	COG1090	epimerase
C2L60_08225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2L60_08230	COG0625	glutathione transferase activity
C2L60_08235	COG0625	glutathione transferase activity
C2L60_08240	COG0622	Phosphoesterase
C2L60_08245	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2L60_08250	COG0857	belongs to the CobB CobQ family
C2L60_08250	COG0280	phosphate acetyltransferase
C2L60_08255	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2L60_08270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2L60_08275	COG0490	domain, Protein
C2L60_08275	COG0471	metal ion transport
C2L60_08285	COG0436	Aminotransferase
C2L60_08290	COG0583	DNA-binding transcription factor activity
C2L60_08320	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C2L60_08330	COG1034	ATP synthesis coupled electron transport
C2L60_08345	COG0839	Belongs to the complex I subunit 6 family
C2L60_08355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2L60_08360	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2L60_08375	COG2153	protein acetylation
C2L60_08380	COG1169	isochorismate synthase
C2L60_08405	COG0318	PFAM AMP-dependent synthetase and ligase
C2L60_08415	COG5464	transposase or invertase
C2L60_08430	COG1414	Transcriptional regulator
C2L60_08440	COG2271	Major facilitator Superfamily
C2L60_08450	COG0247	lactate metabolic process
C2L60_08460	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2L60_08465	COG2271	Major facilitator Superfamily
C2L60_08470	COG0584	glycerophosphoryl diester phosphodiesterase
C2L60_08480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2L60_08510	COG2205	protein histidine kinase activity
C2L60_08510	COG0784	Response regulator, receiver
C2L60_08520	COG2198	Histidine kinase
C2L60_08520	COG0642	Histidine kinase
C2L60_08535	COG2169	Transcriptional regulator
C2L60_08535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2L60_08540	COG3145	DNA-N1-methyladenine dioxygenase activity
C2L60_08545	COG4615	Cyclic peptide transporter
C2L60_08550	COG2239	Acts as a magnesium transporter
C2L60_08555	COG0659	secondary active sulfate transmembrane transporter activity
C2L60_08570	COG0628	permease
C2L60_08595	COG1349	DNA-binding transcription factor activity
C2L60_08600	COG0494	nUDIX hydrolase
C2L60_08620	COG1061	Type III restriction enzyme res subunit
C2L60_08625	COG1187	pseudouridine synthase activity
C2L60_08630	COG2814	Major facilitator Superfamily
C2L60_08640	COG4172	Belongs to the ABC transporter superfamily
C2L60_08645	COG4239	(ABC) transporter, permease
C2L60_08650	COG4174	ABC transporter (Permease)
C2L60_08655	COG4166	transmembrane transport
C2L60_08660	COG2200	EAL domain
C2L60_08665	COG0791	NLP P60 protein
C2L60_08670	COG0671	phosphoesterase, PA-phosphatase related
C2L60_08675	COG0523	cobalamin synthesis protein
C2L60_08680	COG0246	Mannitol dehydrogenase
C2L60_08685	COG1312	Catalyzes the dehydration of D-mannonate
C2L60_08715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_08715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_08720	COG1105	Belongs to the carbohydrate kinase PfkB family
C2L60_08725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2L60_08725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2L60_08725	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2L60_08735	COG2855	membrane
C2L60_08745	COG0583	DNA-binding transcription factor activity
C2L60_08750	COG0833	amino acid
C2L60_08765	COG4771	TonB-dependent receptor
C2L60_08780	COG2311	Membrane
C2L60_08795	COG1129	ABC transporter
C2L60_08805	COG2949	membrane
C2L60_08820	COG1346	cytolysis
C2L60_08830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2L60_08835	COG3659	wide pore channel activity
C2L60_08850	COG2723	6-phospho-beta-galactosidase activity
C2L60_08855	COG1538	Outer membrane efflux protein
C2L60_08860	COG0586	Pfam SNARE associated Golgi protein
C2L60_08870	COG1686	Belongs to the peptidase S11 family
C2L60_08880	COG0277	FAD linked oxidase domain protein
C2L60_08885	COG1472	Belongs to the glycosyl hydrolase 3 family
C2L60_08890	COG1732	Glycine betaine
C2L60_08895	COG1174	glycine betaine transport
C2L60_08900	COG1125	glycine betaine transport
C2L60_08905	COG1174	glycine betaine transport
C2L60_08915	COG3275	phosphorelay sensor kinase activity
C2L60_08925	COG4807	Protein conserved in bacteria
C2L60_08945	COG5455	response to cobalt ion
C2L60_08950	COG0583	DNA-binding transcription factor activity
C2L60_08955	COG2252	PERMEase
C2L60_08965	COG0583	DNA-binding transcription factor activity
C2L60_08980	COG0351	phosphomethylpyrimidine kinase
C2L60_08985	COG1830	Aldolase
C2L60_09020	COG1070	Carbohydrate kinase
C2L60_09030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2L60_09035	COG4948	Mandelate Racemase Muconate Lactonizing
C2L60_09040	COG0747	negative chemotaxis
C2L60_09045	COG0601	transmembrane transport
C2L60_09055	COG0444	Belongs to the ABC transporter superfamily
C2L60_09060	COG4608	Belongs to the ABC transporter superfamily
C2L60_09075	COG0745	RESPONSE REGULATOR receiver
C2L60_09080	COG2205	protein histidine kinase activity
C2L60_09105	COG1301	dicarboxylic acid transport
C2L60_09120	COG5002	protein histidine kinase activity
C2L60_09125	COG0443	Heat shock 70 kDa protein
C2L60_09135	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2L60_09150	COG2982	Protein involved in outer membrane biogenesis
C2L60_09155	COG1253	flavin adenine dinucleotide binding
C2L60_09205	COG0463	Glycosyl transferase, family 2
C2L60_09220	COG2244	polysaccharide biosynthetic process
C2L60_09230	COG1088	dTDP-glucose 4,6-dehydratase activity
C2L60_09265	COG1088	dTDP-glucose 4,6-dehydratase activity
C2L60_09330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2L60_09360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2L60_09365	COG0583	DNA-binding transcription factor activity
C2L60_09375	COG0531	amino acid
C2L60_09380	COG0640	Transcriptional regulator
C2L60_09385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2L60_09390	COG2925	Exonuclease
C2L60_09405	COG3344	reverse transcriptase
C2L60_09415	COG1289	transmembrane transporter activity
C2L60_09435	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2L60_09445	COG1942	4-Oxalocrotonate Tautomerase
C2L60_09450	COG0583	DNA-binding transcription factor activity
C2L60_09455	COG0095	Lipoate-protein ligase
C2L60_09460	COG0477	Major facilitator Superfamily
C2L60_09475	COG5001	Diguanylate cyclase
C2L60_09475	COG3300	MHYT domain
C2L60_09485	COG3615	Tellurite resistance protein tehB
C2L60_09510	COG3706	GGDEF domain
C2L60_09575	COG2003	Belongs to the UPF0758 family
C2L60_09630	COG3504	Conjugal transfer protein
C2L60_09695	COG4771	TonB-dependent receptor
C2L60_09700	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2L60_09720	COG3433	isochorismatase activity
C2L60_09720	COG2226	methyltransferase
C2L60_09720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2L60_09735	COG1132	(ABC) transporter
C2L60_09740	COG2814	Major facilitator Superfamily
C2L60_09745	COG1169	isochorismate synthase
C2L60_09750	COG0582	viral genome integration into host DNA
C2L60_09760	COG0534	Mate efflux family protein
C2L60_09770	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2L60_09790	COG0604	alcohol dehydrogenase
C2L60_09795	COG1309	transcriptional regulator
C2L60_09800	COG0025	NhaP-type Na H and K H
C2L60_09845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L60_09855	COG1418	mRNA catabolic process
C2L60_09860	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2L60_09865	COG3727	T/G mismatch-specific endonuclease activity
C2L60_09870	COG0697	spore germination
C2L60_09875	COG2354	Protein conserved in bacteria
C2L60_09905	COG0366	Alpha amylase catalytic
C2L60_09930	COG2197	response regulator
C2L60_09940	COG2197	response regulator
C2L60_09950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2L60_09980	COG3012	SEC-C Motif Domain Protein
C2L60_09980	COG3318	Belongs to the UPF0149 family
C2L60_09985	COG0814	amino acid
C2L60_09995	COG1528	Iron-storage protein
C2L60_10010	COG0477	Major facilitator Superfamily
C2L60_10020	COG2211	Major facilitator Superfamily
C2L60_10030	COG1528	Iron-storage protein
C2L60_10040	COG1879	ABC-type sugar transport system periplasmic component
C2L60_10050	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L60_10075	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2L60_10085	COG3102	Protein conserved in bacteria
C2L60_10105	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C2L60_10110	COG1801	Protein of unknown function DUF72
C2L60_10115	COG1335	isochorismatase
C2L60_10125	COG0494	nUDIX hydrolase
C2L60_10150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2L60_10160	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2L60_10165	COG0739	heme binding
C2L60_10170	COG1560	Kdo2-lipid A biosynthetic process
C2L60_10180	COG1737	Transcriptional regulator
C2L60_10195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2L60_10200	COG0129	dihydroxy-acid dehydratase activity
C2L60_10205	COG0800	Aldolase
C2L60_10215	COG3141	response to X-ray
C2L60_10220	COG2979	Protein of unknown function (DUF533)
C2L60_10225	COG1770	oligopeptidase
C2L60_10230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2L60_10240	COG2372	response to copper ion
C2L60_10245	COG1276	copper resistance
C2L60_10260	COG2990	Protein conserved in bacteria
C2L60_10285	COG3008	intermembrane lipid transfer
C2L60_10290	COG2995	paraquat-inducible protein a
C2L60_10295	COG1956	GAF domain-containing protein
C2L60_10315	COG2814	Major facilitator Superfamily
C2L60_10325	COG1414	Transcriptional regulator
C2L60_10360	COG1278	Cold shock
C2L60_10365	COG0768	penicillin binding
C2L60_10370	COG2226	methyltransferase
C2L60_10385	COG3716	PTS system mannose fructose sorbose family IID component
C2L60_10390	COG3715	PTS system
C2L60_10395	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_10395	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2L60_10400	COG1253	flavin adenine dinucleotide binding
C2L60_10405	COG2200	EAL domain
C2L60_10410	COG1760	l-serine dehydratase
C2L60_10430	COG0251	oxidation-reduction process
C2L60_10435	COG1199	ATP-dependent helicase activity
C2L60_10445	COG3065	identical protein binding
C2L60_10450	COG0318	PFAM AMP-dependent synthetase and ligase
C2L60_10455	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C2L60_10465	COG2894	cell division
C2L60_10480	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2L60_10510	COG2719	SpoVR family
C2L60_10530	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2L60_10540	COG4774	siderophore transport
C2L60_10555	COG2308	Evidence 4 Homologs of previously reported genes of
C2L60_10595	COG0583	DNA-binding transcription factor activity
C2L60_10600	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2L60_10615	COG1882	Formate acetyltransferase
C2L60_10625	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2L60_10640	COG0410	ABC transporter
C2L60_10645	COG0583	DNA-binding transcription factor activity
C2L60_10765	COG0012	GTP binding
C2L60_10785	COG0659	secondary active sulfate transmembrane transporter activity
C2L60_10790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2L60_10820	COG2890	protein-(glutamine-N5) methyltransferase activity
C2L60_10825	COG3094	Invasion gene expression up-regulator, SirB
C2L60_10830	COG2912	Transglutaminase-like superfamily
C2L60_10840	COG0387	Pfam Sodium calcium exchanger
C2L60_10845	COG4572	Cation transport regulator
C2L60_10850	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2L60_10860	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2L60_10865	COG3707	response regulator
C2L60_10870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L60_10880	COG1116	anion transmembrane transporter activity
C2L60_10885	COG2146	nitrite reductase [NAD(P)H] activity
C2L60_10885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2L60_10890	COG0243	molybdopterin cofactor binding
C2L60_10895	COG4932	domain protein
C2L60_10900	COG2197	response regulator
C2L60_10905	COG3850	Histidine kinase
C2L60_10910	COG2223	nitrite transmembrane transporter activity
C2L60_10915	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2L60_10920	COG1140	nitrate reductase beta subunit
C2L60_10925	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2L60_10930	COG2181	nitrate reductase activity
C2L60_10940	COG1522	sequence-specific DNA binding
C2L60_10975	COG0788	formyltetrahydrofolate deformylase activity
C2L60_10985	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2L60_10990	COG0745	RESPONSE REGULATOR receiver
C2L60_10995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2L60_11000	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2L60_11005	COG1435	thymidine kinase activity
C2L60_11010	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_11010	COG1454	alcohol dehydrogenase
C2L60_11020	COG2095	MarC family integral membrane protein
C2L60_11025	COG4166	transmembrane transport
C2L60_11030	COG0601	transmembrane transport
C2L60_11035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2L60_11040	COG0444	Belongs to the ABC transporter superfamily
C2L60_11050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2L60_11070	COG2353	YceI-like domain
C2L60_11075	COG2350	Protein conserved in bacteria
C2L60_11095	COG1105	Belongs to the carbohydrate kinase PfkB family
C2L60_11100	COG3137	Salt-induced outer membrane protein
C2L60_11140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2L60_11140	COG0072	phenylalanine-tRNA ligase activity
C2L60_11160	COG0583	DNA-binding transcription factor activity
C2L60_11180	COG0386	Belongs to the glutathione peroxidase family
C2L60_11190	COG0791	NLP P60 protein
C2L60_11200	COG4256	Hemin uptake protein
C2L60_11205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2L60_11215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2L60_11215	COG0574	Belongs to the PEP-utilizing enzyme family
C2L60_11225	COG0628	permease
C2L60_11230	COG0247	lactate metabolic process
C2L60_11230	COG0277	FAD linked oxidase domain protein
C2L60_11235	COG2050	protein possibly involved in aromatic compounds catabolism
C2L60_11240	COG2261	transglycosylase associated protein
C2L60_11270	COG1120	ATPase activity
C2L60_11285	COG0583	DNA-binding transcription factor activity
C2L60_11310	COG1304	FMN binding
C2L60_11315	COG1309	transcriptional regulator
C2L60_11330	COG0316	Belongs to the HesB IscA family
C2L60_11335	COG0719	Fe-S assembly protein
C2L60_11340	COG0396	ATPase activity
C2L60_11345	COG0719	Fe-S assembly protein
C2L60_11360	COG1376	ErfK ybiS ycfS ynhG family protein
C2L60_11385	COG1309	transcriptional regulator
C2L60_11395	COG2271	Major facilitator Superfamily
C2L60_11400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2L60_11425	COG1414	Transcriptional regulator
C2L60_11460	COG2814	Major facilitator Superfamily
C2L60_11480	COG0583	DNA-binding transcription factor activity
C2L60_11485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L60_11505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L60_11510	COG1116	anion transmembrane transporter activity
C2L60_11515	COG4774	siderophore transport
C2L60_11520	COG1120	ATPase activity
C2L60_11525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2L60_11530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2L60_11550	COG0765	amino acid transport
C2L60_11555	COG1126	abc transporter atp-binding protein
C2L60_11570	COG2814	Major facilitator Superfamily
C2L60_11585	COG1473	amidohydrolase
C2L60_11590	COG3383	formate dehydrogenase (NAD+) activity
C2L60_11595	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2L60_11605	COG1840	ABC-type Fe3 transport system, periplasmic component
C2L60_11610	COG1175	transmembrane transport
C2L60_11640	COG4133	protoheme IX ABC transporter activity
C2L60_11645	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2L60_11650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2L60_11665	COG1138	Cytochrome C-type biogenesis protein
C2L60_11670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2L60_11675	COG3088	subunit of a heme lyase
C2L60_11675	COG4235	cytochrome complex assembly
C2L60_11715	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C2L60_11745	COG3039	Transposase
C2L60_11760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L60_11795	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_11800	COG2610	gluconate transmembrane transporter activity
C2L60_11805	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L60_11815	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2L60_11825	COG0583	DNA-binding transcription factor activity
C2L60_11850	COG0277	FAD linked oxidase domain protein
C2L60_11855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L60_11880	COG0402	S-adenosylhomocysteine deaminase activity
C2L60_11895	COG0583	DNA-binding transcription factor activity
C2L60_11960	COG4608	Belongs to the ABC transporter superfamily
C2L60_11965	COG0444	Belongs to the ABC transporter superfamily
C2L60_11990	COG0346	lactoylglutathione lyase activity
C2L60_11995	COG1349	DNA-binding transcription factor activity
C2L60_12025	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C2L60_12080	COG0307	riboflavin synthase, alpha
C2L60_12085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2L60_12090	COG2814	Major facilitator Superfamily
C2L60_12095	COG0583	DNA-binding transcription factor activity
C2L60_12110	COG2814	Major facilitator Superfamily
C2L60_12115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2L60_12125	COG0791	NLP P60 protein
C2L60_12130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2L60_12140	COG0346	lactoylglutathione lyase activity
C2L60_12145	COG1902	pentaerythritol trinitrate reductase activity
C2L60_12150	COG1309	transcriptional regulator
C2L60_12155	COG3313	Fe-S protein
C2L60_12160	COG4989	oxidoreductase activity
C2L60_12165	COG2032	superoxide dismutase activity
C2L60_12170	COG1289	transmembrane transporter activity
C2L60_12175	COG1566	PFAM secretion protein HlyD family protein
C2L60_12190	COG3706	GGDEF domain
C2L60_12195	COG3133	Outer membrane lipoprotein
C2L60_12205	COG3895	Periplasmic Protein
C2L60_12220	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2L60_12225	COG0625	glutathione transferase activity
C2L60_12240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2L60_12250	COG4659	FMN binding
C2L60_12285	COG2723	6-phospho-beta-galactosidase activity
C2L60_12295	COG0673	inositol 2-dehydrogenase activity
C2L60_12305	COG2814	Major facilitator Superfamily
C2L60_12310	COG1733	regulation of RNA biosynthetic process
C2L60_12325	COG3038	cytochrome b561
C2L60_12345	COG0583	DNA-binding transcription factor activity
C2L60_12350	COG3485	protocatechuate 3,4-dioxygenase
C2L60_12355	COG3485	protocatechuate 3,4-dioxygenase
C2L60_12360	COG5383	Protein conserved in bacteria
C2L60_12365	COG2272	Belongs to the type-B carboxylesterase lipase family
C2L60_12380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2L60_12385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2L60_12390	COG1275	C4-dicarboxylate transporter malic acid transport protein
C2L60_12395	COG0500	methyltransferase
C2L60_12410	COG3708	Transcriptional regulator
C2L60_12410	COG2207	Transcriptional regulator
C2L60_12415	COG3135	benzoate transporter
C2L60_12420	COG1396	sequence-specific DNA binding
C2L60_12430	COG0826	peptidase U32
C2L60_12450	COG1294	oxidase, subunit
C2L60_12455	COG1271	oxidase subunit
C2L60_12460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L60_12465	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2L60_12470	COG3842	ATPase activity
C2L60_12475	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2L60_12480	COG1177	transmembrane transport
C2L60_12485	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_12515	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_12520	COG0747	negative chemotaxis
C2L60_12530	COG3238	Protein conserved in bacteria
C2L60_12535	COG1247	-acetyltransferase
C2L60_12545	COG2130	NADP-dependent
C2L60_12560	COG3691	Protein conserved in bacteria
C2L60_12565	COG1228	amidohydrolase
C2L60_12570	COG4772	TonB-dependent receptor
C2L60_12600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L60_12610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L60_12625	COG0765	amino acid transport
C2L60_12630	COG1126	abc transporter atp-binding protein
C2L60_12640	COG0625	glutathione transferase activity
C2L60_12670	COG2211	Major facilitator Superfamily
C2L60_12685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2L60_12690	COG3842	ATPase activity
C2L60_12695	COG1840	ABC-type Fe3 transport system, periplasmic component
C2L60_12700	COG1178	ABC-type Fe3 transport system permease component
C2L60_12705	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2L60_12710	COG2181	nitrate reductase activity
C2L60_12715	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2L60_12720	COG1140	nitrate reductase beta subunit
C2L60_12725	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2L60_12745	COG1414	Transcriptional regulator
C2L60_12750	COG4948	Mandelate Racemase Muconate Lactonizing
C2L60_12755	COG4829	muconolactone delta-isomerase
C2L60_12760	COG3485	protocatechuate 3,4-dioxygenase
C2L60_12770	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2L60_12790	COG3383	formate dehydrogenase (NAD+) activity
C2L60_12790	COG0243	molybdopterin cofactor binding
C2L60_12795	COG0243	molybdopterin cofactor binding
C2L60_12795	COG3383	formate dehydrogenase (NAD+) activity
C2L60_12800	COG0437	4 iron, 4 sulfur cluster binding
C2L60_12805	COG2864	formate dehydrogenase
C2L60_12820	COG2326	polyphosphate kinase activity
C2L60_12830	COG2814	Major facilitator Superfamily
C2L60_12840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L60_12860	COG0747	negative chemotaxis
C2L60_12865	COG1064	alcohol dehydrogenase
C2L60_12880	COG0488	(ABC) transporter
C2L60_12920	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_12925	COG3729	General stress protein
C2L60_12940	COG3685	Protein conserved in bacteria
C2L60_12950	COG0366	Alpha amylase catalytic
C2L60_12960	COG2323	membrane
C2L60_12970	COG3111	PFAM Bacterial OB fold (BOF) protein
C2L60_12975	COG1764	response to oxidative stress
C2L60_13000	COG3781	membrane
C2L60_13005	COG0243	molybdopterin cofactor binding
C2L60_13010	COG0583	DNA-binding transcription factor activity
C2L60_13015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2L60_13040	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2L60_13045	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2L60_13050	COG2814	Major facilitator Superfamily
C2L60_13060	COG1285	pathogenesis
C2L60_13065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2L60_13075	COG0583	DNA-binding transcription factor activity
C2L60_13095	COG0519	Catalyzes the synthesis of GMP from XMP
C2L60_13095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2L60_13135	COG0596	Alpha beta hydrolase
C2L60_13140	COG0745	RESPONSE REGULATOR receiver
C2L60_13145	COG2205	protein histidine kinase activity
C2L60_13160	COG0076	glutamate decarboxylase activity
C2L60_13165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2L60_13170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L60_13175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L60_13180	COG1116	anion transmembrane transporter activity
C2L60_13185	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2L60_13195	COG0673	inositol 2-dehydrogenase activity
C2L60_13210	COG3706	GGDEF domain
C2L60_13215	COG0402	S-adenosylhomocysteine deaminase activity
C2L60_13220	COG1953	Uracil, thiamine, allantoin
C2L60_13255	COG0406	alpha-ribazole phosphatase activity
C2L60_13265	COG1335	isochorismatase
C2L60_13305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2L60_13380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2L60_13390	COG2070	2-Nitropropane dioxygenase
C2L60_13395	COG0583	DNA-binding transcription factor activity
C2L60_13405	COG1902	pentaerythritol trinitrate reductase activity
C2L60_13410	COG4529	Protein conserved in bacteria
C2L60_13415	COG0477	Major facilitator Superfamily
C2L60_13445	COG2223	nitrite transmembrane transporter activity
C2L60_13455	COG1609	Transcriptional regulator
C2L60_13460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_13470	COG3037	sugar-specific permease SgaT UlaA
C2L60_13475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2L60_13485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2L60_13490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2L60_13490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2L60_13490	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2L60_13505	COG0583	DNA-binding transcription factor activity
C2L60_13510	COG0583	DNA-binding transcription factor activity
C2L60_13515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2L60_13525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2L60_13540	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L60_13550	COG1609	Transcriptional regulator
C2L60_13580	COG1652	LysM domain
C2L60_13595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2L60_13595	COG0426	domain, Protein
C2L60_13610	COG1840	ABC-type Fe3 transport system, periplasmic component
C2L60_13625	COG0456	acetyltransferase
C2L60_13625	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2L60_13635	COG0667	Aldo Keto reductase
C2L60_13640	COG0667	Aldo Keto reductase
C2L60_13650	COG0667	Aldo Keto reductase
C2L60_13665	COG4977	sequence-specific DNA binding
C2L60_13685	COG4977	sequence-specific DNA binding
C2L60_13690	COG1349	DNA-binding transcription factor activity
C2L60_13705	COG1349	DNA-binding transcription factor activity
C2L60_13710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2L60_13715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2L60_13720	COG0738	Major facilitator superfamily
C2L60_13765	COG1929	Belongs to the glycerate kinase type-1 family
C2L60_13770	COG3835	regulator
C2L60_13790	COG2186	Transcriptional regulator
C2L60_13795	COG1263	PTS System
C2L60_13795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2L60_13810	COG2814	Major facilitator Superfamily
C2L60_13815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_13815	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_13825	COG2819	hydrolase of the alpha beta superfamily
C2L60_13830	COG5001	Diguanylate cyclase
C2L60_13830	COG3300	MHYT domain
C2L60_13845	COG0024	Methionine aminopeptidase
C2L60_13865	COG3188	usher protein
C2L60_13880	COG3550	peptidyl-serine autophosphorylation
C2L60_13885	COG1396	sequence-specific DNA binding
C2L60_13890	COG2351	hydroxyisourate hydrolase activity
C2L60_13895	COG3195	allantoin biosynthetic process
C2L60_13895	COG3648	Uricase
C2L60_13900	COG2233	PERMEase
C2L60_13930	COG2207	Transcriptional regulator
C2L60_13945	COG4628	conserved protein (DUF2132)
C2L60_13965	COG2011	ABC-type metal ion transport system permease component
C2L60_13970	COG2070	2-Nitropropane dioxygenase
C2L60_13980	COG0477	Major facilitator Superfamily
C2L60_13995	COG0477	Major facilitator Superfamily
C2L60_14060	COG2199	diguanylate cyclase activity
C2L60_14075	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_14080	COG0583	DNA-binding transcription factor activity
C2L60_14090	COG0039	L-malate dehydrogenase activity
C2L60_14095	COG1349	DNA-binding transcription factor activity
C2L60_14100	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2L60_14105	COG3395	kinase activity
C2L60_14115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2L60_14130	COG2731	YhcH YjgK YiaL family protein
C2L60_14135	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_14155	COG1846	Transcriptional regulator
C2L60_14160	COG4977	sequence-specific DNA binding
C2L60_14170	COG0697	spore germination
C2L60_14175	COG2814	Major facilitator Superfamily
C2L60_14185	COG0410	ABC transporter
C2L60_14190	COG1129	ABC transporter
C2L60_14200	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2L60_14205	COG0683	leucine binding
C2L60_14210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2L60_14245	COG2223	nitrite transmembrane transporter activity
C2L60_14250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2L60_14265	COG1349	DNA-binding transcription factor activity
C2L60_14270	COG2084	Dehydrogenase
C2L60_14275	COG3395	kinase activity
C2L60_14280	COG0235	Class ii aldolase
C2L60_14285	COG3622	Belongs to the hyi family
C2L60_14290	COG2610	gluconate transmembrane transporter activity
C2L60_14295	COG3708	Transcriptional regulator
C2L60_14295	COG2207	Transcriptional regulator
C2L60_14310	COG2200	EAL domain
C2L60_14315	COG1546	Belongs to the CinA family
C2L60_14320	COG0071	Belongs to the small heat shock protein (HSP20) family
C2L60_14330	COG2197	response regulator
C2L60_14335	COG2135	peptidase activity
C2L60_14340	COG2207	Transcriptional regulator
C2L60_14355	COG4221	oxidoreductase activity
C2L60_14360	COG1802	Transcriptional regulator
C2L60_14365	COG0589	response to stress
C2L60_14370	COG0246	Mannitol dehydrogenase
C2L60_14375	COG2271	Major facilitator Superfamily
C2L60_14390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2L60_14405	COG0243	molybdopterin cofactor binding
C2L60_14410	COG0437	4 iron, 4 sulfur cluster binding
C2L60_14415	COG3302	dmso reductase anchor subunit
C2L60_14430	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2L60_14435	COG1940	carbohydrate kinase activity
C2L60_14440	COG0583	DNA-binding transcription factor activity
C2L60_14445	COG2814	Major facilitator Superfamily
C2L60_14450	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2L60_14460	COG3591	Belongs to the peptidase S1B family
C2L60_14480	COG0628	permease
C2L60_14510	COG0679	Auxin Efflux Carrier
C2L60_14520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2L60_14545	COG3290	protein histidine kinase activity
C2L60_14550	COG4565	transcriptional regulatory protein
C2L60_14560	COG1053	succinate dehydrogenase
C2L60_14575	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2L60_14575	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2L60_14595	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2L60_14600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2L60_14610	COG0183	Belongs to the thiolase family
C2L60_14615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2L60_14625	COG1414	Transcriptional regulator
C2L60_14630	COG2840	Smr protein MutS2
C2L60_14635	COG0583	DNA-binding transcription factor activity
C2L60_14645	COG1473	amidohydrolase
C2L60_14650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C2L60_14660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2L60_14665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2L60_14680	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2L60_14685	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2L60_14705	COG0531	amino acid
C2L60_14715	COG3136	membrane protein required for alginate biosynthesis
C2L60_14720	COG0745	RESPONSE REGULATOR receiver
C2L60_14730	COG2205	protein histidine kinase activity
C2L60_14740	COG0114	fumarate hydratase activity
C2L60_14745	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2L60_14745	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2L60_14750	COG1482	cell wall glycoprotein biosynthetic process
C2L60_14755	COG5339	Protein conserved in bacteria
C2L60_14760	COG1609	Transcriptional regulator
C2L60_14765	COG1263	PTS System
C2L60_14765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2L60_14770	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2L60_14795	COG2391	methyltransferase activity
C2L60_14800	COG0425	Belongs to the sulfur carrier protein TusA family
C2L60_14805	COG5562	phage envelope protein
C2L60_14810	COG0401	homolog of Blt101
C2L60_14815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2L60_14820	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_14825	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2L60_14830	COG0477	Major facilitator Superfamily
C2L60_14835	COG1113	amino acid transport
C2L60_14840	COG2988	succinylglutamate desuccinylase activity
C2L60_14845	COG3724	N-succinylarginine dihydrolase activity
C2L60_14850	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_14855	COG3138	arginine N-succinyltransferase
C2L60_14860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2L60_14865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2L60_14870	COG0667	Aldo Keto reductase
C2L60_14875	COG0583	DNA-binding transcription factor activity
C2L60_14895	COG1538	Outer membrane efflux protein
C2L60_14905	COG1643	Atp-dependent helicase
C2L60_14920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2L60_14925	COG3327	negative regulation of DNA-templated transcription, initiation
C2L60_14930	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C2L60_14935	COG0183	Belongs to the thiolase family
C2L60_14940	COG2050	protein possibly involved in aromatic compounds catabolism
C2L60_14945	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L60_14950	COG1024	Enoyl-CoA hydratase
C2L60_14955	COG1024	Enoyl-CoA hydratase
C2L60_14960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2L60_14965	COG2151	metal-sulfur cluster biosynthetic enzyme
C2L60_14970	COG3396	Phenylacetate-CoA oxygenase
C2L60_14975	COG3460	Phenylacetate-CoA oxygenase
C2L60_14980	COG3396	Phenylacetate-CoA oxygenase
C2L60_14985	COG2030	dehydratase
C2L60_14985	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_15015	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_15020	COG2207	Transcriptional regulator
C2L60_15025	COG3784	Protein of unknown function (DUF1318)
C2L60_15035	COG2911	Protein conserved in bacteria
C2L60_15040	COG0586	Pfam SNARE associated Golgi protein
C2L60_15045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2L60_15050	COG3187	Heat shock protein
C2L60_15055	COG3042	response to heat
C2L60_15065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2L60_15065	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2L60_15065	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2L60_15065	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2L60_15070	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L60_15080	COG0589	response to stress
C2L60_15090	COG0513	Belongs to the DEAD box helicase family
C2L60_15110	COG1349	DNA-binding transcription factor activity
C2L60_15115	COG0673	inositol 2-dehydrogenase activity
C2L60_15130	COG1113	amino acid transport
C2L60_15135	COG1522	sequence-specific DNA binding
C2L60_15145	COG1448	Aminotransferase
C2L60_15150	COG2011	ABC-type metal ion transport system permease component
C2L60_15165	COG0436	Aminotransferase
C2L60_15195	COG0583	DNA-binding transcription factor activity
C2L60_15215	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_15220	COG1309	transcriptional regulator
C2L60_15225	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_15310	COG2885	chlorophyll binding
C2L60_15335	COG3039	Transposase
C2L60_15435	COG0741	lytic transglycosylase activity
C2L60_15435	COG0739	heme binding
C2L60_15435	COG1196	nuclear chromosome segregation
C2L60_15505	COG3567	Phage-associated protein, HI1409 family
C2L60_15510	COG1783	phage Terminase large subunit
C2L60_15530	COG3772	lysozyme
C2L60_15540	COG0484	heat shock protein binding
C2L60_15590	COG3039	Transposase
C2L60_15650	COG0582	viral genome integration into host DNA
C2L60_15655	COG0693	protein deglycase activity
C2L60_15660	COG1078	dGTPase activity
C2L60_15665	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_15670	COG0583	DNA-binding transcription factor activity
C2L60_15690	COG0656	L-ascorbic acid biosynthetic process
C2L60_15720	COG4166	transmembrane transport
C2L60_15725	COG2866	Carboxypeptidase
C2L60_15730	COG4948	Mandelate Racemase Muconate Lactonizing
C2L60_15735	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2L60_15740	COG3180	Ammonia monooxygenase
C2L60_15745	COG3283	Transcriptional regulator of aromatic amino acids metabolism
C2L60_15750	COG1486	melibiose metabolic process
C2L60_15755	COG0583	DNA-binding transcription factor activity
C2L60_15765	COG3106	COG3106 Predicted ATPase
C2L60_15775	COG1983	PspC domain protein
C2L60_15785	COG1842	Phage shock protein A
C2L60_15790	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2L60_15800	COG1473	amidohydrolase
C2L60_15815	COG0702	epimerase
C2L60_15825	COG4168	peptide transport system, permease
C2L60_15830	COG2135	peptidase activity
C2L60_15840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2L60_15845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2L60_15850	COG3344	reverse transcriptase
C2L60_15875	COG3316	Transposase and inactivated derivatives
C2L60_15900	COG3316	Transposase and inactivated derivatives
C2L60_15930	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2L60_16045	COG4171	peptide transport system, permease
C2L60_16060	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2L60_16070	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2L60_16075	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2L60_16075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2L60_16090	COG1349	DNA-binding transcription factor activity
C2L60_16100	COG0023	Translation Initiation Factor
C2L60_16110	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2L60_16115	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C2L60_16120	COG0671	phosphoesterase, PA-phosphatase related
C2L60_16130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2L60_16150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2L60_16160	COG0616	signal peptide processing
C2L60_16170	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_16175	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C2L60_16180	COG1187	pseudouridine synthase activity
C2L60_16185	COG0583	DNA-binding transcription factor activity
C2L60_16195	COG0009	L-threonylcarbamoyladenylate synthase
C2L60_16205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2L60_16210	COG0512	Glutamine amidotransferase of anthranilate synthase
C2L60_16210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2L60_16215	COG0135	phosphoribosylanthranilate isomerase activity
C2L60_16215	COG0134	indole-3-glycerol-phosphate synthase activity
C2L60_16270	COG4774	siderophore transport
C2L60_16280	COG3047	cAMP biosynthetic process
C2L60_16305	COG1607	acyl-coa hydrolase
C2L60_16315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2L60_16320	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_16325	COG1988	membrane-bound metal-dependent
C2L60_16340	COG0753	catalase activity
C2L60_16350	COG1486	melibiose metabolic process
C2L60_16355	COG1917	Cupin 2, conserved barrel domain protein
C2L60_16355	COG2169	Transcriptional regulator
C2L60_16360	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2L60_16365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2L60_16370	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2L60_16375	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2L60_16385	COG0322	excinuclease ABC activity
C2L60_16390	COG3678	ATP-independent chaperone mediated protein folding
C2L60_16400	COG3724	N-succinylarginine dihydrolase activity
C2L60_16410	COG3138	arginine N-succinyltransferase
C2L60_16420	COG0708	Exodeoxyribonuclease III
C2L60_16425	COG0398	Pfam SNARE associated Golgi protein
C2L60_16430	COG0398	Pfam SNARE associated Golgi protein
C2L60_16435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2L60_16440	COG4134	Bacterial extracellular solute-binding protein
C2L60_16445	COG4135	transport system, permease component
C2L60_16450	COG4136	ATPase activity
C2L60_16455	COG2897	thiosulfate sulfurtransferase activity
C2L60_16460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2L60_16465	COG0494	nUDIX hydrolase
C2L60_16470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2L60_16480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2L60_16485	COG0709	Synthesizes selenophosphate from selenide and ATP
C2L60_16505	COG0778	Nitroreductase
C2L60_16510	COG0616	signal peptide processing
C2L60_16515	COG0252	asparaginase activity
C2L60_16520	COG1335	isochorismatase
C2L60_16525	COG2814	Major facilitator Superfamily
C2L60_16530	COG1349	DNA-binding transcription factor activity
C2L60_16535	COG0667	Aldo Keto reductase
C2L60_16540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2L60_16545	COG0191	fructose-bisphosphate aldolase activity
C2L60_16550	COG1063	alcohol dehydrogenase
C2L60_16555	COG2271	Major facilitator Superfamily
C2L60_16560	COG1063	alcohol dehydrogenase
C2L60_16570	COG1403	HNH endonuclease
C2L60_16575	COG3139	Protein of unknown function (DUF1315)
C2L60_16585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2L60_16600	COG3713	MltA-interacting MipA family protein
C2L60_16605	COG2766	serine protein kinase
C2L60_16620	COG0386	Belongs to the glutathione peroxidase family
C2L60_16640	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_16645	COG0583	DNA-binding transcription factor activity
C2L60_16650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2L60_16655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2L60_16660	COG3344	reverse transcriptase
C2L60_16675	COG0859	PFAM glycosyl transferase family 9
C2L60_16680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2L60_16690	COG2207	Transcriptional regulator
C2L60_16695	COG2807	transmembrane transport
C2L60_16700	COG0504	CTP synthase activity
C2L60_16705	COG1683	Conserved Protein
C2L60_16710	COG3189	MarR family transcriptional regulator
C2L60_16715	COG3042	response to heat
C2L60_16720	COG2203	Gaf domain
C2L60_16720	COG2199	diguanylate cyclase activity
C2L60_16740	COG3182	Iron-regulated membrane protein
C2L60_16750	COG1560	Kdo2-lipid A biosynthetic process
C2L60_16765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2L60_16770	COG3706	GGDEF domain
C2L60_16775	COG0583	DNA-binding transcription factor activity
C2L60_16780	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2L60_16805	COG1294	oxidase, subunit
C2L60_16810	COG1271	oxidase subunit
C2L60_16815	COG3546	catalase activity
C2L60_16820	COG3685	Protein conserved in bacteria
C2L60_16825	COG3685	Protein conserved in bacteria
C2L60_16830	COG3729	General stress protein
C2L60_16835	COG1063	alcohol dehydrogenase
C2L60_16840	COG3813	Protein conserved in bacteria
C2L60_16855	COG0640	Transcriptional regulator
C2L60_16860	COG0538	isocitrate dehydrogenase activity
C2L60_16950	COG0616	signal peptide processing
C2L60_16965	COG1802	Transcriptional regulator
C2L60_16965	COG4626	Terminase
C2L60_17005	COG3772	lysozyme
C2L60_17020	COG1403	HNH endonuclease
C2L60_17045	COG3344	reverse transcriptase
C2L60_17055	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C2L60_17100	COG1396	sequence-specific DNA binding
C2L60_17125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2L60_17135	COG0582	viral genome integration into host DNA
C2L60_17140	COG0538	isocitrate dehydrogenase activity
C2L60_17145	COG1187	pseudouridine synthase activity
C2L60_17165	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2L60_17185	COG2205	protein histidine kinase activity
C2L60_17190	COG2850	peptidyl-arginine hydroxylation
C2L60_17205	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2L60_17210	COG1177	transmembrane transport
C2L60_17215	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2L60_17225	COG0318	PFAM AMP-dependent synthetase and ligase
C2L60_17235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2L60_17245	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2L60_17255	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2L60_17265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2L60_17270	COG1388	LysM domain
C2L60_17270	COG1376	ErfK ybiS ycfS ynhG family protein
C2L60_17280	COG1309	transcriptional regulator
C2L60_17290	COG3134	Outer membrane lipoprotein
C2L60_17295	COG1252	NADH dehydrogenase
C2L60_17320	COG5633	Lipoprotein
C2L60_17325	COG0537	adenosine 5'-monophosphoramidase activity
C2L60_17335	COG0084	hydrolase, TatD family'
C2L60_17340	COG0470	DNA polymerase III
C2L60_17350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2L60_17355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2L60_17360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2L60_17370	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_17375	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2L60_17395	COG1399	metal-binding, possibly nucleic acid-binding protein
C2L60_17415	COG1530	ribonuclease E activity
C2L60_17420	COG0583	DNA-binding transcription factor activity
C2L60_17425	COG2814	Major facilitator Superfamily
C2L60_17445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2L60_17495	COG1560	Kdo2-lipid A biosynthetic process
C2L60_17515	COG5645	(Lipo)protein
C2L60_17555	COG3381	protein complex oligomerization
C2L60_17585	COG0583	DNA-binding transcription factor activity
C2L60_17595	COG1335	isochorismatase
C2L60_17615	COG1702	phosphate starvation-inducible protein PhoH
C2L60_17630	COG0672	)-iron permease
C2L60_17635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2L60_17645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2L60_17665	COG1309	transcriptional regulator
C2L60_17700	COG2233	PERMEase
C2L60_17710	COG3729	General stress protein
C2L60_17730	COG1733	regulation of RNA biosynthetic process
C2L60_17735	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_17750	COG0531	amino acid
C2L60_17760	COG0174	glutamine synthetase
C2L60_17765	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2L60_17770	COG1917	Cupin 2, conserved barrel domain protein
C2L60_17770	COG1396	sequence-specific DNA binding
C2L60_17775	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_17780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L60_17785	COG0583	DNA-binding transcription factor activity
C2L60_17790	COG0473	3-isopropylmalate dehydrogenase activity
C2L60_17800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2L60_17805	COG4638	Rieske (2fe-2S)
C2L60_17810	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_17815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2L60_17825	COG2200	EAL domain
C2L60_17830	COG2200	EAL domain
C2L60_17845	COG0670	Belongs to the BI1 family
C2L60_17860	COG2207	Transcriptional regulator
C2L60_17865	COG1881	PFAM PEBP family protein
C2L60_17880	COG1832	CoA-binding protein
C2L60_17890	COG0210	DNA helicase
C2L60_17895	COG3304	Inner membrane component domain
C2L60_17900	COG1289	transmembrane transporter activity
C2L60_17905	COG3070	regulator of competence-specific genes
C2L60_17930	COG1067	ATP-dependent peptidase activity
C2L60_17940	COG3130	regulation of translation
C2L60_17950	COG3009	Protein conserved in bacteria
C2L60_17955	COG3008	intermembrane lipid transfer
C2L60_17955	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2L60_17960	COG2995	paraquat-inducible protein a
C2L60_17965	COG0488	(ABC) transporter
C2L60_17975	COG3217	Mosc domain protein beta barrel domain protein
C2L60_17975	COG0633	Ferredoxin
C2L60_17990	COG0431	NADPH-dependent FMN reductase
C2L60_17995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L60_18000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L60_18005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L60_18015	COG0308	aminopeptidase N
C2L60_18030	COG1473	amidohydrolase
C2L60_18040	COG0814	amino acid
C2L60_18050	COG1522	sequence-specific DNA binding
C2L60_18065	COG1448	Aminotransferase
C2L60_18070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2L60_18075	COG3108	Peptidase M15
C2L60_18085	COG2989	Protein conserved in bacteria
C2L60_18095	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2L60_18105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2L60_18110	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2L60_18115	COG3173	Aminoglycoside phosphotransferase
C2L60_18130	COG3214	Protein conserved in bacteria
C2L60_18145	COG2333	competence protein COMEC
C2L60_18145	COG0658	competence protein
C2L60_18155	COG0539	negative regulation of cytoplasmic translation
C2L60_18175	COG2323	membrane
C2L60_18180	COG1944	ATP diphosphatase activity
C2L60_18185	COG2116	formate transmembrane transporter activity
C2L60_18190	COG1882	Formate acetyltransferase
C2L60_18195	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2L60_18200	COG0477	Major facilitator Superfamily
C2L60_18210	COG3302	dmso reductase anchor subunit
C2L60_18215	COG0437	4 iron, 4 sulfur cluster binding
C2L60_18220	COG0243	molybdopterin cofactor binding
C2L60_18230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2L60_18240	COG1178	ABC-type Fe3 transport system permease component
C2L60_18240	COG1674	ftsk spoiiie
C2L60_18250	COG0492	ferredoxin-NADP+ reductase activity
C2L60_18255	COG4988	ABC transporter
C2L60_18260	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2L60_18275	COG0542	response to heat
C2L60_18285	COG1278	Cold shock
C2L60_18300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L60_18305	COG3593	DNA synthesis involved in DNA repair
C2L60_18310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2L60_18315	COG2431	L-lysine efflux transmembrane transporter activity
C2L60_18325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2L60_18335	COG0028	Belongs to the TPP enzyme family
C2L60_18340	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C2L60_18345	COG0702	epimerase
C2L60_18350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2L60_18355	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2L60_18360	COG2203	Gaf domain
C2L60_18360	COG4251	negative regulation of phosphorylation
C2L60_18360	COG5001	Diguanylate cyclase
C2L60_18360	COG3706	GGDEF domain
C2L60_18375	COG1126	abc transporter atp-binding protein
C2L60_18380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L60_18385	COG4215	(ABC) transporter
C2L60_18390	COG4160	amino acid transport
C2L60_18395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L60_18400	COG5002	protein histidine kinase activity
C2L60_18405	COG0745	RESPONSE REGULATOR receiver
C2L60_18420	COG1177	transmembrane transport
C2L60_18425	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2L60_18430	COG3842	ATPase activity
C2L60_18435	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2L60_18460	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2L60_18620	COG4695	Portal protein
C2L60_18655	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2L60_18695	COG3344	reverse transcriptase
C2L60_18705	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2L60_18710	COG3226	Transcriptional regulator
C2L60_18715	COG0738	Major facilitator superfamily
C2L60_18720	COG0561	phosphatase activity
C2L60_18725	COG2814	Major facilitator Superfamily
C2L60_18735	COG0671	phosphoesterase, PA-phosphatase related
C2L60_18740	COG1349	DNA-binding transcription factor activity
C2L60_18745	COG1686	Belongs to the peptidase S11 family
C2L60_18750	COG0625	glutathione transferase activity
C2L60_18755	COG2133	pyrroloquinoline quinone binding
C2L60_18765	COG2223	nitrite transmembrane transporter activity
C2L60_18790	COG0747	negative chemotaxis
C2L60_18805	COG0303	'Molybdopterin
C2L60_18810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2L60_18815	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2L60_18825	COG0561	phosphatase activity
C2L60_18835	COG1609	Transcriptional regulator
C2L60_18840	COG2271	Major facilitator Superfamily
C2L60_18855	COG0488	(ABC) transporter
C2L60_18860	COG2365	Tyrosine phosphatase family
C2L60_18865	COG1376	ErfK ybiS ycfS ynhG family protein
C2L60_18870	COG2188	Transcriptional regulator
C2L60_18875	COG2723	6-phospho-beta-galactosidase activity
C2L60_18880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2L60_18885	COG1321	iron dependent repressor
C2L60_18895	COG2194	sulfuric ester hydrolase activity
C2L60_18900	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2L60_18915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L60_18920	COG0765	amino acid transport
C2L60_18925	COG1126	abc transporter atp-binding protein
C2L60_18930	COG0668	transmembrane transport
C2L60_18940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2L60_18950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2L60_18960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2L60_18965	COG1199	ATP-dependent helicase activity
C2L60_18970	COG0513	Belongs to the DEAD box helicase family
C2L60_18975	COG3958	Transketolase
C2L60_18980	COG3959	Transketolase, thiamine diphosphate binding domain
C2L60_18985	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_18990	COG2271	Major facilitator Superfamily
C2L60_18995	COG0583	DNA-binding transcription factor activity
C2L60_19000	COG1309	transcriptional regulator
C2L60_19005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L60_19010	COG1131	(ABC) transporter
C2L60_19015	COG0842	Transport permease protein
C2L60_19020	COG0842	Transport permease protein
C2L60_19035	COG3568	Endonuclease Exonuclease Phosphatase
C2L60_19040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2L60_19045	COG0392	lysyltransferase activity
C2L60_19060	COG0670	Belongs to the BI1 family
C2L60_19065	COG0314	molybdopterin synthase activity
C2L60_19070	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2L60_19080	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2L60_19105	COG0745	RESPONSE REGULATOR receiver
C2L60_19110	COG0642	Histidine kinase
C2L60_19135	COG0410	ABC transporter
C2L60_19145	COG2226	methyltransferase
C2L60_19165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2L60_19170	COG1881	PFAM PEBP family protein
C2L60_19210	COG4677	pectinesterase activity
C2L60_19240	COG0789	Transcriptional regulator
C2L60_19245	COG2200	EAL domain
C2L60_19270	COG0561	phosphatase activity
C2L60_19275	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2L60_19280	COG4149	molybdate abc transporter
C2L60_19285	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2L60_19295	COG3585	molybdate ion transport
C2L60_19295	COG2005	Transcriptional regulator
C2L60_19300	COG1119	ATPase activity
C2L60_19310	COG1085	galactose-1-phosphate uridylyltransferase
C2L60_19320	COG2017	converts alpha-aldose to the beta-anomer
C2L60_19330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2L60_19345	COG3201	nicotinamide mononucleotide transporter
C2L60_19350	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2L60_19390	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2L60_19395	COG2885	chlorophyll binding
C2L60_19405	COG3064	Membrane
C2L60_19410	COG0848	biopolymer transport protein
C2L60_19415	COG0811	peptide transport
C2L60_19420	COG0824	Thioesterase
C2L60_19425	COG3790	cyd operon protein YbgE
C2L60_19430	COG4890	Cyd operon protein YbgT
C2L60_19435	COG1294	oxidase, subunit
C2L60_19440	COG1271	oxidase subunit
C2L60_19450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2L60_19460	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2L60_19465	COG0567	Dehydrogenase, E1 component
C2L60_19470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2L60_19475	COG1053	succinate dehydrogenase
C2L60_19480	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2L60_19485	COG2009	succinate dehydrogenase
C2L60_19530	COG1984	allophanate hydrolase subunit 2
C2L60_19535	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2L60_19540	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2L60_19550	COG0415	Belongs to the DNA photolyase family
C2L60_19580	COG2205	protein histidine kinase activity
C2L60_19585	COG0745	RESPONSE REGULATOR receiver
C2L60_19595	COG0033	Phosphoglucomutase
C2L60_19605	COG0596	Alpha beta hydrolase
C2L60_19620	COG0735	belongs to the Fur family
C2L60_19665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2L60_19670	COG1940	carbohydrate kinase activity
C2L60_19670	COG1846	Transcriptional regulator
C2L60_19675	COG0647	UMP catabolic process
C2L60_19680	COG0367	asparagine synthase
C2L60_19725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2L60_19735	COG1702	phosphate starvation-inducible protein PhoH
C2L60_19745	COG4535	Mg2 and Co2 transporter CorC
C2L60_19760	COG0765	amino acid transport
C2L60_19765	COG0765	amino acid transport
C2L60_19770	COG1126	abc transporter atp-binding protein
C2L60_19775	COG3039	Transposase
C2L60_19795	COG2888	peptidyl-tyrosine sulfation
C2L60_19810	COG1466	dna polymerase III delta subunit
C2L60_19830	COG0799	negative regulation of ribosome biogenesis
C2L60_19840	COG0768	penicillin binding
C2L60_19845	COG0772	Belongs to the SEDS family
C2L60_19850	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2L60_19855	COG1686	Belongs to the peptidase S11 family
C2L60_19870	COG0583	DNA-binding transcription factor activity
C2L60_19885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2L60_19895	COG1278	Cold shock
C2L60_19910	COG3069	C4-dicarboxylate transmembrane transporter activity
C2L60_19915	COG3719	Belongs to the RNase T2 family
C2L60_19920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2L60_19925	COG0589	response to stress
C2L60_19935	COG0450	alkyl hydroperoxide reductase
C2L60_19940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2L60_19945	COG0583	DNA-binding transcription factor activity
C2L60_19950	COG3969	phosphoadenosine phosphosulfate
C2L60_19955	COG1475	DNA binding
C2L60_19960	COG0436	Aminotransferase
C2L60_19985	COG1129	ABC transporter
C2L60_19990	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L60_19995	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L60_20005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2L60_20020	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2L60_20030	COG0402	S-adenosylhomocysteine deaminase activity
C2L60_20040	COG0483	inositol monophosphate 1-phosphatase activity
C2L60_20045	COG2271	Major facilitator Superfamily
C2L60_20075	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L60_20080	COG1129	ABC transporter
C2L60_20085	COG0371	Dehydrogenase
C2L60_20090	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_20105	COG2879	small protein
C2L60_20110	COG1966	Carbon starvation protein
C2L60_20120	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_20125	COG3433	isochorismatase activity
C2L60_20125	COG1535	isochorismatase
C2L60_20130	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2L60_20135	COG1169	isochorismate synthase
C2L60_20140	COG4592	Periplasmic binding protein
C2L60_20150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2L60_20155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2L60_20160	COG1120	ATPase activity
C2L60_20165	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2L60_20165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2L60_20170	COG3251	PFAM MbtH domain protein
C2L60_20175	COG2382	esterase
C2L60_20180	COG4771	TonB-dependent receptor
C2L60_20185	COG2977	Belongs to the P-Pant transferase superfamily
C2L60_20190	COG3958	Transketolase
C2L60_20195	COG3959	Transketolase, thiamine diphosphate binding domain
C2L60_20205	COG2390	Transcriptional regulator
C2L60_20210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2L60_20215	COG1879	ABC-type sugar transport system periplasmic component
C2L60_20225	COG1129	ABC transporter
C2L60_20230	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L60_20240	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_20250	COG0583	DNA-binding transcription factor activity
C2L60_20255	COG0668	transmembrane transport
C2L60_20265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2L60_20295	COG0747	negative chemotaxis
C2L60_20300	COG0601	transmembrane transport
C2L60_20305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2L60_20310	COG0444	Belongs to the ABC transporter superfamily
C2L60_20315	COG4608	Belongs to the ABC transporter superfamily
C2L60_20330	COG4221	oxidoreductase activity
C2L60_20340	COG4215	(ABC) transporter
C2L60_20345	COG0765	amino acid transport
C2L60_20350	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2L60_20365	COG0697	spore germination
C2L60_20375	COG3698	Phosphodiester glycosidase
C2L60_20425	COG2315	Protein conserved in bacteria
C2L60_20430	COG0778	Nitroreductase
C2L60_20440	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2L60_20450	COG3716	PTS system mannose fructose sorbose family IID component
C2L60_20455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2L60_20460	COG2222	sugar isomerase
C2L60_20465	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2L60_20465	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2L60_20485	COG0477	Major facilitator Superfamily
C2L60_20490	COG0668	transmembrane transport
C2L60_20520	COG3188	usher protein
C2L60_20535	COG2771	luxR family
C2L60_20545	COG0673	inositol 2-dehydrogenase activity
C2L60_20555	COG2211	Major facilitator Superfamily
C2L60_20560	COG1113	amino acid transport
C2L60_20575	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_20580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L60_20590	COG0531	amino acid
C2L60_20640	COG0667	Aldo Keto reductase
C2L60_20645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L60_20650	COG1473	amidohydrolase
C2L60_20670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2L60_20675	COG1120	ATPase activity
C2L60_20680	COG1566	PFAM secretion protein HlyD family protein
C2L60_20725	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L60_20730	COG1129	ABC transporter
C2L60_20745	COG0673	inositol 2-dehydrogenase activity
C2L60_20775	COG3104	oligopeptide transport
C2L60_20780	COG1982	Orn Lys Arg decarboxylase major
C2L60_20785	COG0531	amino acid
C2L60_20790	COG3710	Transcriptional regulator
C2L60_20800	COG1560	Kdo2-lipid A biosynthetic process
C2L60_20815	COG3188	usher protein
C2L60_20820	COG3121	Chaperone
C2L60_20825	COG3539	Fimbrial protein
C2L60_20885	COG2501	S4 domain
C2L60_20895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2L60_20915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2L60_20920	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2L60_20935	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2L60_20940	COG4181	ATPase activity
C2L60_20945	COG2755	lipolytic protein G-D-S-L family
C2L60_20950	COG0300	oxidoreductase activity
C2L60_20955	COG3118	belongs to the thioredoxin family
C2L60_20965	COG0390	transport system, permease component
C2L60_20970	COG4619	ABC transporter
C2L60_20975	COG0330	HflC and HflK could
C2L60_20980	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2L60_20995	COG3735	TraB family
C2L60_21000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2L60_21010	COG2223	nitrite transmembrane transporter activity
C2L60_21015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2L60_21015	COG4651	solute:proton antiporter activity
C2L60_21020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2L60_21065	COG2832	Protein of unknown function (DUF454)
C2L60_21070	COG3923	Primosomal replication protein n
C2L60_21080	COG5464	transposase or invertase
C2L60_21085	COG3264	Mechanosensitive ion channel
C2L60_21085	COG1196	nuclear chromosome segregation
C2L60_21110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L60_21115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L60_21130	COG0110	maltose O-acetyltransferase activity
C2L60_21175	COG1874	Beta-galactosidase
C2L60_21180	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C2L60_21185	COG3833	ABC-type maltose transport systems, permease component
C2L60_21190	COG1175	transmembrane transport
C2L60_21195	COG2182	Extracellular solute-binding protein
C2L60_21205	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2L60_21220	COG2364	Membrane
C2L60_21250	COG3695	enzyme binding
C2L60_21255	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C2L60_21260	COG1946	Acyl-CoA thioesterase
C2L60_21265	COG0004	ammonium transporteR
C2L60_21270	COG0347	Belongs to the P(II) protein family
C2L60_21275	COG1132	(ABC) transporter
C2L60_21280	COG1132	(ABC) transporter
C2L60_21285	COG1522	sequence-specific DNA binding
C2L60_21300	COG4533	DNA binding
C2L60_21310	COG0824	Thioesterase
C2L60_21315	COG1555	photosystem II stabilization
C2L60_21320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2L60_21325	COG0776	regulation of translation
C2L60_21330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2L60_21360	COG0271	Belongs to the BolA IbaG family
C2L60_21365	COG3056	Lipoprotein
C2L60_21370	COG2223	nitrite transmembrane transporter activity
C2L60_21375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2L60_21380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2L60_21385	COG1845	cytochrome c oxidase, subunit III
C2L60_21390	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2L60_21405	COG1414	Transcriptional regulator
C2L60_21410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2L60_21415	COG1053	succinate dehydrogenase
C2L60_21425	COG1053	succinate dehydrogenase
C2L60_21440	COG0673	inositol 2-dehydrogenase activity
C2L60_21445	COG2814	Major facilitator Superfamily
C2L60_21455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2L60_21460	COG0693	protein deglycase activity
C2L60_21480	COG0142	geranyltranstransferase activity
C2L60_21490	COG0667	Aldo Keto reductase
C2L60_21495	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2L60_21515	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2L60_21515	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2L60_21525	COG4238	major outer membrane lipoprotein
C2L60_21545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2L60_21550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2L60_21555	COG1862	Preprotein translocase
C2L60_21575	COG0450	alkyl hydroperoxide reductase
C2L60_21580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_21595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2L60_21605	COG1228	amidohydrolase
C2L60_21615	COG1335	isochorismatase
C2L60_21620	COG0583	DNA-binding transcription factor activity
C2L60_21625	COG0366	Alpha amylase catalytic
C2L60_21635	COG1114	Component of the transport system for branched-chain amino acids
C2L60_21650	COG0420	3'-5' exonuclease activity
C2L60_21655	COG0419	ATPase involved in DNA repair
C2L60_21660	COG1940	carbohydrate kinase activity
C2L60_21675	COG4126	flavin adenine dinucleotide binding
C2L60_21685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2L60_21690	COG3416	Protein conserved in bacteria
C2L60_21700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2L60_21710	COG1785	Belongs to the alkaline phosphatase family
C2L60_21730	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2L60_21750	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C2L60_21755	COG1335	isochorismatase
C2L60_21760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2L60_21765	COG0113	porphobilinogen synthase activity
C2L60_21775	COG2175	clavaminate synthase activity
C2L60_21780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L60_21785	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2L60_21790	COG4521	taurine ABC transporter
C2L60_21795	COG2040	homocysteine
C2L60_21800	COG0833	amino acid
C2L60_21810	COG4303	Ethanolamine ammonia lyase large subunit
C2L60_21815	COG4302	ethanolamine ammonia-lyase activity
C2L60_21835	COG0411	ABC transporter
C2L60_21840	COG0410	ABC transporter
C2L60_21850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L60_21855	COG1126	abc transporter atp-binding protein
C2L60_21860	COG0765	amino acid transport
C2L60_21865	COG0765	amino acid transport
C2L60_21880	COG3188	usher protein
C2L60_21905	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C2L60_21915	COG3639	organic phosphonate transmembrane transporter activity
C2L60_21945	COG0791	NLP P60 protein
C2L60_21970	COG0582	viral genome integration into host DNA
C2L60_21975	COG1192	Involved in chromosome partitioning
C2L60_22035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2L60_22040	COG0022	dehydrogenase e1 component
C2L60_22045	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2L60_22050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2L60_22065	COG1830	Aldolase
C2L60_22075	COG1070	Carbohydrate kinase
C2L60_22080	COG1028	Short-chain dehydrogenase reductase Sdr
C2L60_22085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2L60_22090	COG3775	system Galactitol-specific IIC component
C2L60_22095	COG0625	glutathione transferase activity
C2L60_22100	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2L60_22120	COG0579	oxidoreductase
C2L60_22125	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_22130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2L60_22135	COG1113	amino acid transport
C2L60_22140	COG1802	Transcriptional regulator
C2L60_22160	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2L60_22165	COG0454	-acetyltransferase
C2L60_22180	COG2991	Protein conserved in bacteria
C2L60_22195	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2L60_22200	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2L60_22220	COG3034	peptidoglycan biosynthetic process
C2L60_22225	COG0121	glutamine amidotransferase
C2L60_22235	COG1960	acyl-CoA dehydrogenase activity
C2L60_22240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2L60_22250	COG0583	DNA-binding transcription factor activity
C2L60_22265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2L60_22275	COG2226	methyltransferase
C2L60_22285	COG0741	lytic transglycosylase activity
C2L60_22285	COG1388	LysM domain
C2L60_22290	COG2226	methyltransferase
C2L60_22300	COG2814	Major facilitator Superfamily
C2L60_22305	COG0583	DNA-binding transcription factor activity
C2L60_22310	COG0656	L-ascorbic acid biosynthetic process
C2L60_22350	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2L60_22360	COG2011	ABC-type metal ion transport system permease component
C2L60_22365	COG1464	Belongs to the NlpA lipoprotein family
C2L60_22375	COG1720	tRNA m6t6A37 methyltransferase activity
C2L60_22385	COG0791	NLP P60 protein
C2L60_22390	COG3015	lipoprotein NlpE involved in copper resistance
C2L60_22395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C2L60_22400	COG4681	YaeQ
C2L60_22410	COG4568	rho-dependent transcription termination
C2L60_22420	COG0346	lactoylglutathione lyase activity
C2L60_22465	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C2L60_22475	COG0750	zinc metalloprotease
C2L60_22480	COG0575	Belongs to the CDS family
C2L60_22495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2L60_22520	COG0024	Methionine aminopeptidase
C2L60_22525	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2L60_22540	COG3835	regulator
C2L60_22545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2L60_22565	COG2860	membrane
C2L60_22585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2L60_22590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2L60_22595	COG1120	ATPase activity
C2L60_22605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2L60_22695	COG1643	Atp-dependent helicase
C2L60_22700	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2L60_22710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2L60_22720	COG0617	tRNA 3'-terminal CCA addition
C2L60_22725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2L60_22745	COG0726	polysaccharide deacetylase
C2L60_22750	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_22755	COG0842	Transport permease protein
C2L60_22760	COG1131	(ABC) transporter
C2L60_22765	COG0288	reversible hydration of carbon dioxide
C2L60_22775	COG4993	Dehydrogenase
C2L60_22780	COG2132	Multicopper oxidase
C2L60_22835	COG3064	Membrane
C2L60_22850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2L60_22855	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2L60_22860	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2L60_22865	COG2186	Transcriptional regulator
C2L60_22870	COG1113	amino acid transport
C2L60_22875	COG2211	Major facilitator Superfamily
C2L60_22880	COG3940	Belongs to the glycosyl hydrolase 43 family
C2L60_22885	COG3725	Membrane protein required for beta-lactamase induction
C2L60_22890	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2L60_22900	COG4969	Belongs to the N-Me-Phe pilin family
C2L60_22905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2L60_22910	COG1459	type II secretion system
C2L60_22920	COG0237	dephospho-CoA kinase activity
C2L60_22935	COG0494	nUDIX hydrolase
C2L60_22955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2L60_22960	COG0849	cell division
C2L60_22970	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2L60_22985	COG0772	Belongs to the SEDS family
C2L60_23000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2L60_23005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2L60_23010	COG0768	penicillin binding
C2L60_23035	COG1609	Transcriptional regulator
C2L60_23045	COG0028	Belongs to the TPP enzyme family
C2L60_23095	COG0738	Major facilitator superfamily
C2L60_23105	COG0583	DNA-binding transcription factor activity
C2L60_23110	COG2271	Major facilitator Superfamily
C2L60_23115	COG2814	Major facilitator Superfamily
C2L60_23130	COG4143	(ABC) transporter
C2L60_23135	COG1178	ABC-type Fe3 transport system permease component
C2L60_23145	COG0586	Pfam SNARE associated Golgi protein
C2L60_23165	COG0235	Class ii aldolase
C2L60_23170	COG0417	DNA replication proofreading
C2L60_23180	COG0564	pseudouridine synthase activity
C2L60_23195	COG3493	citrate carrier protein
C2L60_23210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2L60_23215	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2L60_23225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2L60_23280	COG0505	Belongs to the CarA family
C2L60_23350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2L60_23375	COG1047	Peptidyl-prolyl cis-trans
C2L60_23390	COG0196	riboflavin kinase activity
C2L60_23410	COG0583	DNA-binding transcription factor activity
C2L60_23435	COG4735	regulation of single-species biofilm formation
C2L60_23440	COG1584	GPR1 FUN34 yaaH family protein
C2L60_23445	COG0477	Major facilitator Superfamily
C2L60_23450	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2L60_23460	COG1115	amino acid carrier protein
C2L60_23475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2L60_23485	COG0527	aspartate kinase activity
C2L60_23485	COG0460	homoserine dehydrogenase
C2L60_23495	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2L60_23510	COG0745	RESPONSE REGULATOR receiver
C2L60_23515	COG4452	Inner membrane protein CreD
C2L60_23520	COG2205	protein histidine kinase activity
C2L60_23525	COG0745	RESPONSE REGULATOR receiver
C2L60_23530	COG3045	CreA protein
C2L60_23535	COG2207	Transcriptional regulator
C2L60_23535	COG3708	Transcriptional regulator
C2L60_23555	COG0741	lytic transglycosylase activity
C2L60_23565	COG0488	(ABC) transporter
C2L60_23575	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2L60_23580	COG0560	Phosphoserine phosphatase
C2L60_23620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2L60_23625	COG0084	hydrolase, TatD family'
C2L60_23630	COG4667	esterase of the alpha-beta hydrolase superfamily
C2L60_23640	COG2823	Periplasmic or secreted lipoprotein
C2L60_23650	COG1011	Hydrolase
C2L60_23655	COG0456	acetyltransferase
C2L60_23660	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C2L60_23690	COG3706	GGDEF domain
C2L60_23695	COG4114	ferric iron reductase
C2L60_23700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2L60_23705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2L60_23710	COG2197	response regulator
C2L60_23715	COG2197	response regulator
C2L60_23735	COG2966	Psort location CytoplasmicMembrane, score
C2L60_23750	COG1484	DNA-dependent DNA replication
C2L60_23765	COG5464	transposase or invertase
C2L60_23775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2L60_23780	COG3716	PTS system mannose fructose sorbose family IID component
C2L60_23785	COG3715	PTS system
C2L60_23800	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2L60_23800	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2L60_23810	COG1063	alcohol dehydrogenase
C2L60_23815	COG1802	Transcriptional regulator
C2L60_23820	COG2271	Major facilitator Superfamily
C2L60_23825	COG0456	acetyltransferase
C2L60_23825	COG1214	PFAM Peptidase M22, glycoprotease
C2L60_23835	COG1737	Transcriptional regulator
C2L60_23840	COG0800	Aldolase
C2L60_23845	COG3734	2-keto-3-deoxy-galactonokinase
C2L60_23860	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2L60_23890	COG1846	Transcriptional regulator
C2L60_23900	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2L60_23910	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_23915	COG3384	dioxygenase
C2L60_23925	COG3971	2-oxopent-4-enoate hydratase activity
C2L60_23945	COG2368	4-hydroxyphenylacetate
C2L60_23950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2L60_23965	COG1966	Carbon starvation protein
C2L60_23970	COG2879	small protein
C2L60_23975	COG0523	cobalamin synthesis protein
C2L60_23985	COG1012	belongs to the aldehyde dehydrogenase family
C2L60_23990	COG5464	transposase or invertase
C2L60_23995	COG2207	Transcriptional regulator
C2L60_23995	COG1917	Cupin 2, conserved barrel domain protein
C2L60_24005	COG2733	membrane
C2L60_24010	COG2814	Major facilitator Superfamily
C2L60_24020	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C2L60_24025	COG1924	4 iron, 4 sulfur cluster binding
C2L60_24040	COG1566	PFAM secretion protein HlyD family protein
C2L60_24050	COG5457	Domain of unknown function (DUF1127)
C2L60_24055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L60_24065	COG0583	DNA-binding transcription factor activity
C2L60_24070	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2L60_24080	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L60_24085	COG1129	ABC transporter
C2L60_24090	COG1879	ABC-type sugar transport system periplasmic component
C2L60_24100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L60_24105	COG1129	ABC transporter
C2L60_24105	COG0842	Transport permease protein
C2L60_24110	COG0842	Transport permease protein
C2L60_24150	COG2850	peptidyl-arginine hydroxylation
C2L60_24165	COG5002	protein histidine kinase activity
C2L60_24170	COG0745	RESPONSE REGULATOR receiver
C2L60_24180	COG1538	Outer membrane efflux protein
C2L60_24185	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L60_24190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L60_24195	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L60_24205	COG3040	lipid binding
C2L60_24210	COG0789	Transcriptional regulator
C2L60_24220	COG0300	oxidoreductase activity
C2L60_24235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2L60_24255	COG3272	Protein of unknown function (DUF1722)
C2L60_24260	COG4580	involved in the transport of maltose and maltodextrins
C2L60_24270	COG2211	Major facilitator Superfamily
C2L60_24275	COG3507	Belongs to the glycosyl hydrolase 43 family
C2L60_24390	COG3039	Transposase
C2L60_24400	COG0582	viral genome integration into host DNA
C2L60_24415	COG0288	reversible hydration of carbon dioxide
C2L60_24420	COG0659	secondary active sulfate transmembrane transporter activity
C2L60_24425	COG1064	alcohol dehydrogenase
C2L60_24435	COG0395	ABC-type sugar transport system, permease component
C2L60_24440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2L60_24445	COG3842	ATPase activity
C2L60_24450	COG1653	transport
C2L60_24460	COG1082	Xylose isomerase domain protein TIM barrel
C2L60_24470	COG3962	Belongs to the TPP enzyme family
C2L60_24475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2L60_24480	COG1737	Transcriptional regulator
C2L60_24480	COG0837	glucose binding
C2L60_24515	COG3718	enzyme involved in inositol metabolism
C2L60_24530	COG0433	COG0433 Predicted ATPase
C2L60_24535	COG0795	lipopolysaccharide-transporting ATPase activity
C2L60_24540	COG0795	lipopolysaccharide-transporting ATPase activity
C2L60_24555	COG2927	DNA polymerase III (CHI subunit)
C2L60_24560	COG0525	valine-tRNA ligase activity
C2L60_24575	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C2L60_24585	COG2188	Transcriptional regulator
C2L60_24590	COG1288	antiporter activity
C2L60_24595	COG1228	amidohydrolase
C2L60_24600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2L60_24605	COG2222	sugar isomerase
C2L60_24610	COG2731	YhcH YjgK YiaL family protein
C2L60_24650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2L60_24650	COG1263	PTS System
C2L60_24655	COG0366	Alpha amylase catalytic
C2L60_24660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2L60_24665	COG1486	melibiose metabolic process
C2L60_24685	COG0602	queuosine metabolic process
C2L60_24690	COG2026	Addiction module toxin, RelE StbE family
C2L60_24695	COG3077	Addiction module antitoxin, RelB DinJ family
C2L60_24700	COG3711	transcriptional antiterminator
C2L60_24700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L60_24705	COG2706	6-phosphogluconolactonase activity
C2L60_24720	COG3964	amidohydrolase
C2L60_24750	COG3783	Cytochrome b(562)
C2L60_24755	COG0312	modulator of DNA gyrase
C2L60_24775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2L60_24785	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L60_24790	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L60_24795	COG1129	ABC transporter
C2L60_24800	COG1879	ABC-type sugar transport system periplasmic component
C2L60_24805	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2L60_24820	COG2105	PFAM AIG2 family protein
C2L60_24825	COG2911	Protein conserved in bacteria
C2L60_24830	COG0729	surface antigen
C2L60_24840	COG1253	flavin adenine dinucleotide binding
C2L60_24855	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2L60_24870	COG1733	regulation of RNA biosynthetic process
C2L60_24875	COG0702	epimerase
C2L60_24885	COG0697	spore germination
C2L60_24895	COG1113	amino acid transport
C2L60_24900	COG0545	Peptidyl-prolyl cis-trans isomerase
C2L60_24905	COG3061	Opacity-associated protein A
C2L60_24920	COG2965	DNA replication, synthesis of RNA primer
C2L60_24960	COG3414	Phosphotransferase system galactitol-specific IIB component
C2L60_24980	COG1073	alpha beta
C2L60_24985	COG3650	response to hydrogen peroxide
C2L60_24995	COG1960	acyl-CoA dehydrogenase activity
C2L60_25000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2L60_25005	COG0557	exoribonuclease II activity
C2L60_25020	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2L60_25030	COG0330	HflC and HflK could
C2L60_25035	COG0330	HflC and HflK could
C2L60_25040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2L60_25060	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2L60_25065	COG0802	atpase or kinase
C2L60_25070	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2L60_25070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2L60_25075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2L60_25090	COG1192	Involved in chromosome partitioning
C2L60_25125	COG0629	single-stranded DNA binding
C2L60_25135	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2L60_25325	COG2003	Belongs to the UPF0758 family
C2L60_25365	COG3316	Transposase and inactivated derivatives
C2L60_25420	COG3316	Transposase and inactivated derivatives
C2L60_25470	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2L60_25470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2L60_25475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2L60_25480	COG1252	NADH dehydrogenase
C2L60_25485	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C2L60_25550	COG4372	Transposase
C2L60_25575	COG0583	DNA-binding transcription factor activity
C2L60_25590	COG0583	DNA-binding transcription factor activity
C2L60_25605	COG2837	iron assimilation
C2L60_25610	COG0582	viral genome integration into host DNA
C2L60_25635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L60_25660	COG1511	domain protein
C2L60_25660	COG3264	Mechanosensitive ion channel
C2L60_25665	COG0531	amino acid
C2L60_25675	COG1053	succinate dehydrogenase
C2L60_25680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2L60_25700	COG2076	Multidrug Resistance protein
C2L60_25705	COG5510	response to toxic substance
C2L60_25720	COG1509	lysine 2,3-aminomutase activity
C2L60_25735	COG3121	Chaperone
C2L60_25790	COG0531	amino acid
C2L60_25795	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2L60_25805	COG1027	Aspartate ammonia-lyase
C2L60_25810	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2L60_25825	COG1309	transcriptional regulator
C2L60_25860	COG0457	Tetratricopeptide repeat
C2L60_25865	COG1649	PFAM Uncharacterised BCR, COG1649
C2L60_25865	COG0726	polysaccharide deacetylase
C2L60_25870	COG1215	transferase activity, transferring glycosyl groups
C2L60_25890	COG0861	Integral membrane protein TerC family
C2L60_25925	COG1486	melibiose metabolic process
C2L60_25935	COG2169	Transcriptional regulator
C2L60_25950	COG2824	Alkylphosphonate utilization operon protein PhnA
C2L60_25955	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C2L60_25960	COG2188	Transcriptional regulator
C2L60_25965	COG3624	Phosphonate C-P lyase system protein PhnG
C2L60_25970	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C2L60_25975	COG3626	phosphonate metabolism
C2L60_25980	COG3627	carbon phosphorus lyase activity
C2L60_25985	COG4107	phosphonate C-P lyase system protein PhnK
C2L60_25990	COG4778	phosphonate C-P lyase system protein PhnL
C2L60_25995	COG3454	Phosphonate metabolism
C2L60_26005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2L60_26015	COG0784	Response regulator, receiver
C2L60_26015	COG4191	Histidine kinase
C2L60_26020	COG1129	ABC transporter
C2L60_26025	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L60_26030	COG1879	ABC-type sugar transport system periplasmic component
C2L60_26060	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2L60_26065	COG1301	dicarboxylic acid transport
C2L60_26075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2L60_26085	COG3162	membrane
C2L60_26115	COG3539	Fimbrial protein
C2L60_26120	COG1346	cytolysis
C2L60_26125	COG1380	Effector of murein hydrolase LrgA
C2L60_26130	COG0583	DNA-binding transcription factor activity
C2L60_26135	COG0025	NhaP-type Na H and K H
C2L60_26140	COG2252	PERMEase
C2L60_26145	COG0625	glutathione transferase activity
C2L60_26150	COG0789	Transcriptional regulator
C2L60_26160	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2L60_26195	COG1234	tRNA 3'-trailer cleavage
C2L60_26200	COG1609	Transcriptional regulator
C2L60_26205	COG0483	inositol monophosphate 1-phosphatase activity
C2L60_26220	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2L60_26240	COG4771	TonB-dependent receptor
C2L60_26245	COG0741	lytic transglycosylase activity
C2L60_26260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2L60_26265	COG2315	Protein conserved in bacteria
C2L60_26270	COG0432	Pfam Uncharacterised protein family UPF0047
C2L60_26285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2L60_26290	COG0305	Participates in initiation and elongation during chromosome replication
C2L60_26305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2L60_26315	COG0735	belongs to the Fur family
C2L60_26320	COG3237	CsbD-like
C2L60_26325	COG0534	Mate efflux family protein
C2L60_26335	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2L60_26410	COG0251	oxidation-reduction process
C2L60_26420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2L60_26440	COG0527	aspartate kinase activity
C2L60_26495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2L60_26525	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2L60_26535	COG0456	acetyltransferase
C2L60_26575	COG0151	Belongs to the GarS family
C2L60_26585	COG4191	Histidine kinase
C2L60_26590	COG3678	ATP-independent chaperone mediated protein folding
C2L60_26600	COG0776	regulation of translation
C2L60_26605	COG3068	Protein conserved in bacteria
C2L60_26625	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2L60_26640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2L60_26645	COG2104	thiamine diphosphate biosynthetic process
C2L60_26665	COG3706	GGDEF domain
C2L60_26675	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2L60_26680	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2L60_26720	COG0250	Participates in transcription elongation, termination and antitermination
C2L60_26725	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2L60_26770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2L60_26805	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2L60_26815	COG1739	Uncharacterized protein family UPF0029
C2L60_26860	COG0805	protein transport
C2L60_26870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2L60_26880	COG3165	ubiquinone biosynthetic process from chorismate
C2L60_26890	COG1322	Protein conserved in bacteria
C2L60_26910	COG0583	DNA-binding transcription factor activity
C2L60_26920	COG0561	phosphatase activity
C2L60_26925	COG2267	carboxylic ester hydrolase activity
C2L60_26930	COG1280	lysine exporter protein (LysE YggA)
C2L60_26940	COG1280	lysine exporter protein (LysE YggA)
C2L60_26955	COG2050	protein possibly involved in aromatic compounds catabolism
C2L60_26965	COG0598	Magnesium transport protein CorA
C2L60_26975	COG0210	DNA helicase
C2L60_26980	COG1011	Hydrolase
C2L60_27000	COG5567	small periplasmic lipoprotein
C2L60_27010	COG3072	Adenylate cyclase
C2L60_27025	COG2959	enzyme of heme biosynthesis
C2L60_27030	COG3071	HemY protein
C2L60_27055	COG1113	amino acid transport
C2L60_27075	COG2244	polysaccharide biosynthetic process
C2L60_27080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2L60_27085	COG0456	acetyltransferase
C2L60_27090	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2L60_27095	COG1088	dTDP-glucose 4,6-dehydratase activity
C2L60_27100	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2L60_27105	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2L60_27115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2L60_27120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2L60_27130	COG3118	belongs to the thioredoxin family
C2L60_27160	COG1811	Na channel or pump
C2L60_27170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2L60_27175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2L60_27185	COG0583	DNA-binding transcription factor activity
C2L60_27190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2L60_27200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2L60_27205	COG3978	acetolactate synthase activity
C2L60_27225	COG3085	chromosome segregation
C2L60_27300	COG0583	DNA-binding transcription factor activity
C2L60_27325	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2L60_27340	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2L60_27345	COG2207	Transcriptional regulator
C2L60_27355	COG0371	Dehydrogenase
C2L60_27360	COG0697	spore germination
C2L60_27370	COG0583	DNA-binding transcription factor activity
C2L60_27380	COG0737	Belongs to the 5'-nucleotidase family
C2L60_27390	COG0460	homoserine dehydrogenase
C2L60_27390	COG0527	aspartate kinase activity
C2L60_27395	COG0626	cystathionine gamma-synthase activity
C2L60_27410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2L60_27415	COG1609	Transcriptional regulator
C2L60_27420	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2L60_27435	COG1575	Belongs to the MenA family. Type 1 subfamily
C2L60_27455	COG3678	ATP-independent chaperone mediated protein folding
C2L60_27460	COG0745	RESPONSE REGULATOR receiver
C2L60_27465	COG2205	protein histidine kinase activity
C2L60_27470	COG2258	MOSC domain
C2L60_27475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2L60_27515	COG1879	ABC-type sugar transport system periplasmic component
C2L60_27520	COG1129	ABC transporter
C2L60_27525	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L60_27530	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L60_27535	COG1454	alcohol dehydrogenase
C2L60_27545	COG2211	Major facilitator Superfamily
C2L60_27605	COG0205	6-phosphofructokinase activity
C2L60_27625	COG0243	molybdopterin cofactor binding
C2L60_27625	COG3383	formate dehydrogenase (NAD+) activity
C2L60_27630	COG0243	molybdopterin cofactor binding
C2L60_27630	COG3383	formate dehydrogenase (NAD+) activity
C2L60_27635	COG0437	4 iron, 4 sulfur cluster binding
C2L60_27640	COG2864	formate dehydrogenase
C2L60_27655	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2L60_27665	COG0456	acetyltransferase
C2L60_27680	COG1011	Hydrolase
C2L60_27695	COG0174	glutamine synthetase
C2L60_27700	COG3852	Histidine kinase
C2L60_27710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2L60_27740	COG0204	Acyl-transferase
C2L60_27750	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2L60_27755	COG3084	Protein conserved in bacteria
C2L60_27765	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2L60_27795	COG2186	Transcriptional regulator
C2L60_27800	COG0477	Major facilitator Superfamily
C2L60_27805	COG1609	Transcriptional regulator
C2L60_27810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2L60_27815	COG1879	ABC-type sugar transport system periplasmic component
C2L60_27820	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L60_27855	COG1522	sequence-specific DNA binding
C2L60_27860	COG0716	FMN binding
C2L60_27875	COG3312	ion transport
C2L60_27925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2L60_27930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2L60_27935	COG0573	inorganic phosphate transmembrane transporter activity
C2L60_27940	COG0581	inorganic phosphate transmembrane transporter activity
C2L60_27945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2L60_27950	COG0704	Plays a role in the regulation of phosphate uptake
C2L60_27965	COG2382	esterase
C2L60_27970	COG0363	glucosamine-6-phosphate deaminase activity
C2L60_27975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2L60_27985	COG2252	PERMEase
C2L60_27990	COG0431	NADPH-dependent FMN reductase
C2L60_28030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2L60_28070	COG3316	Transposase and inactivated derivatives
C2L60_28085	COG3039	Transposase
C2L60_28145	COG2135	peptidase activity
C2L60_28225	COG3316	Transposase and inactivated derivatives
C2L60_28395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2L60_28490	COG3344	reverse transcriptase
C2L60_28650	COG1349	DNA-binding transcription factor activity
C2L60_28660	COG2084	Dehydrogenase
C2L60_28675	COG3316	Transposase and inactivated derivatives
C2L60_28685	COG3316	Transposase and inactivated derivatives
C2L60_28975	COG3344	reverse transcriptase
C2L60_29060	COG3316	Transposase and inactivated derivatives
C2L60_29095	COG3316	Transposase and inactivated derivatives
C2L60_29115	COG3316	Transposase and inactivated derivatives
C2L60_29150	COG3316	Transposase and inactivated derivatives
C2L60_29235	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C2L60_29250	COG3316	Transposase and inactivated derivatives