locus-tag class description HUS01_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUS01_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUS01_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUS01_00025 ENOG410667J hydrolase HUS01_00040 ENOG4105EMF GntR family transcriptional regulator HUS01_00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HUS01_00050 ENOG4108RTU Aldolase HUS01_00070 ENOG4105DJB Major Facilitator Superfamily HUS01_00075 ENOG4105D99 atp gtp-binding protein HUS01_00080 ENOG4105R2A (LipO)protein HUS01_00095 ENOG4105F5P DNA-damage-inducible protein d HUS01_00100 ENOG4105D0C transport protein HUS01_00105 ENOG4105FDP GntR family transcriptional regulator HUS01_00110 ENOG4105CI1 PTS System HUS01_00115 ENOG4105F8D glycoside hydrolase family 4 HUS01_00120 ENOG4105VG5 Membrane HUS01_00125 ENOG4105JP4 Inner membrane protein yidG HUS01_00150 ENOG4105W8I Transcriptional regulator HUS01_00155 ENOG4105E5M Multidrug resistance protein D HUS01_00185 ENOG4105C7K acetolactate synthase HUS01_00190 ENOG4105M71 acetolactate synthase 1 regulatory subunit HUS01_00195 ENOG4108KX4 response regulator HUS01_00200 ENOG4105BZU Histidine kinase HUS01_00205 ENOG4105CXY transporter HUS01_00210 ENOG4105CXY transporter HUS01_00215 ENOG4108SAJ Protein of unknown function (DUF1198) HUS01_00235 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HUS01_00240 ENOG4107STF Involved in phosphonate degradation (By similarity) HUS01_00245 ENOG4106S9K Transcriptional regulator HUS01_00260 ENOG4108MP3 ABC transporter, permease HUS01_00270 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HUS01_00275 ENOG4105VCP PTS System HUS01_00280 ENOG4105CK1 PTS System HUS01_00290 ENOG4105ETE Transcriptional regulator (LacI family HUS01_00295 ENOG4105D2S major facilitator superfamily HUS01_00305 ENOG4107F9Y LysR family transcriptional regulator HUS01_00315 ENOG4105JSC dimethylmenaquinone methyltransferase HUS01_00330 ENOG4105T8A Uncharacterized protein YicS HUS01_00335 ENOG4108UZ3 Transporter HUS01_00340 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) HUS01_00345 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HUS01_00350 ENOG4105C2C drug resistance transporter, Bcr CflA HUS01_00355 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HUS01_00360 ENOG4105BZS acriflavin resistance protein HUS01_00365 ENOG4105C1P efflux transporter, rnd family, mfp subunit HUS01_00385 ENOG410630P Transcriptional regulator HUS01_00395 ENOG4105CR8 Transcriptional regulator HUS01_00420 ENOG4105D01 (LipO)protein HUS01_00435 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HUS01_00445 ENOG4105DQ4 alcohol dehydrogenase HUS01_00465 ENOG4105NI3 Protein of unknown function (DUF3237) HUS01_00475 ENOG4105CT4 transporter HUS01_00480 ENOG4105CJQ hydrolase, family 31 HUS01_00490 ENOG4105F8D glycoside hydrolase family 4 HUS01_00495 ENOG4105CI1 PTS System HUS01_00500 ENOG4105JV1 AsmA family HUS01_00505 ENOG4105C2W permease HUS01_00510 ENOG4105D6U Sodium Glutamate Symporter HUS01_00515 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUS01_00520 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUS01_00525 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HUS01_00530 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HUS01_00545 ENOG4105CP7 Triose-phosphate isomerase HUS01_00550 ENOG4105EBK exported protein HUS01_00555 ENOG4108VTS Membrane HUS01_00560 ENOG4105DP0 ferredoxin-NADP reductase HUS01_00565 ENOG4105CBT Fructose-1,6-bisphosphatase HUS01_00570 ENOG4105CB5 ATP-dependent DNA helicase recG HUS01_00575 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HUS01_00580 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUS01_00590 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HUS01_00595 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HUS01_00600 ENOG4105EN6 Membrane HUS01_00610 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUS01_00615 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) HUS01_00620 ENOG4105DSJ YicC domain protein HUS01_00625 ENOG4105F2I Transposase HUS01_00645 ENOG4105CJ1 ABC, transporter HUS01_00650 ENOG4107QWP ABC-2 type transporter HUS01_00655 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HUS01_00665 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HUS01_00670 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HUS01_00675 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HUS01_00680 ENOG4105W5Q DNA repair protein (RadC HUS01_00685 ENOG4105KDC 50s ribosomal protein l28 HUS01_00690 ENOG4105W0E 50S ribosomal protein L33 HUS01_00695 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUS01_00700 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HUS01_00705 ENOG4106WTF Glycosyl transferase, family 2 HUS01_00710 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HUS01_00715 ENOG4105K64 Glycosyl transferase, family 2 HUS01_00720 ENOG4105CPK Glycosyl transferase (Group 1 HUS01_00730 ENOG4105DKP glycosyl transferase, family 9 HUS01_00755 ENOG4105D16 lipopolysaccharide heptosyltransferase i HUS01_00760 ENOG4105XA0 heptosyltransferase ii HUS01_00765 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HUS01_00770 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUS01_00775 ENOG4105CPQ Dehydrogenase HUS01_00780 ENOG4106WTF Glycosyl transferase, family 2 HUS01_00785 ENOG4105PXI polysaccharide deacetylase HUS01_00790 ENOG41063SB peptidase HUS01_00800 ENOG4107YZP Rhodanese domain protein HUS01_00805 ENOG4105VW4 glutaredoxin 3 HUS01_00810 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HUS01_00815 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUS01_00820 ENOG4105D7W serine acetyltransferase HUS01_00825 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HUS01_00830 ENOG4105DMF Dehydrogenase HUS01_00835 ENOG41073TP transcriptional regulator HUS01_00840 ENOG4105DAA L-lactate HUS01_00845 ENOG4108YYI Protein of unknown function (DUF2810) HUS01_00855 ENOG4105E61 Mannitol repressor protein HUS01_00860 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HUS01_00865 ENOG4105CTS PTS system mannitol-specific HUS01_00870 ENOG4105FP6 Protein of unknown function (DUF3302) HUS01_00875 ENOG4105EFX secretion protein, HlyD family HUS01_00880 ENOG4108U78 Glutathione S-transferase HUS01_00885 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HUS01_00890 ENOG4105EM7 Selenocysteine-specific translation elongation factor HUS01_00895 ENOG4105J4Q Transcriptional regulator HUS01_00900 ENOG4108RC0 Electron transport protein HUS01_00905 ENOG4105JKW Valine--pyruvate aminotransferase HUS01_00910 ENOG4107T9C Alpha amylase catalytic region HUS01_00915 ENOG4108UR8 BAX protein HUS01_00920 ENOG4105T16 Transcriptional regulator (AraC family) HUS01_00925 ENOG4108HWW ABC transporter HUS01_00935 ENOG4105DFW ABC transporter HUS01_00940 ENOG4105C93 Xylose Isomerase HUS01_00945 ENOG4105CMG Carbohydrate kinase HUS01_00950 ENOG410688U Inner membrane protein yiaB HUS01_00955 ENOG4108Z12 YiaAB two helix domain-containing protein HUS01_00960 ENOG4105MEV Acyl-transferase HUS01_00970 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HUS01_00975 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HUS01_00985 ENOG41060TC Hok gef cell toxic protein HUS01_01000 ENOG4105MVF Transcriptional regulator HUS01_01005 ENOG4105D2S major facilitator superfamily HUS01_01010 ENOG4106JH6 (LipO)protein HUS01_01015 ENOG4105C5I Dehydrogenase HUS01_01025 ENOG4105D7K pfkb domain protein HUS01_01035 ENOG4108M60 Transcriptional regulator HUS01_01040 ENOG4108ZG0 Ompa motb domain protein HUS01_01045 ENOG4107QY8 reductase HUS01_01050 ENOG4105HNP -acetyltransferase HUS01_01055 ENOG4108R3E Dna-3-methyladenine glycosylase i HUS01_01060 ENOG4105EAX Putative lipase HUS01_01065 ENOG4105FCD Major Facilitator HUS01_01070 ENOG4105DIJ Phosphoethanolamine transferase HUS01_01095 ENOG4105DEF Extracellular solute-binding protein, family 5 HUS01_01100 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUS01_01105 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUS01_01110 ENOG4105C3U ABC transporter HUS01_01115 ENOG4108JQ7 (ABC) transporter HUS01_01135 ENOG4107QZ7 Cellulose synthase catalytic subunit HUS01_01140 ENOG4107EEX Cellulose synthase regulator protein HUS01_01145 ENOG4105EJG cellulose synthase HUS01_01160 ENOG4105D1V cellulose synthase operon protein YhjU HUS01_01165 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT HUS01_01170 ENOG4105U74 cellulose biosynthesis protein BcsE HUS01_01175 ENOG410661M cytoplasmic protein HUS01_01180 ENOG4105UTS cellulose synthase operon protein YhjQ HUS01_01185 ENOG4107QZ7 Cellulose synthase catalytic subunit HUS01_01190 ENOG4107EEX Cellulose synthase regulator protein HUS01_01195 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HUS01_01200 ENOG4105EJG cellulose synthase HUS01_01205 ENOG4105BZU Histidine kinase HUS01_01210 ENOG4105CK2 sodium dicarboxylate symporter HUS01_01215 ENOG4105CS0 peptidase HUS01_01225 ENOG41066T0 asmA family HUS01_01230 ENOG4105CSH Transporter HUS01_01235 ENOG4107H3J ribonuclease HUS01_01240 ENOG4105CBN LysR family transcriptional regulator HUS01_01245 ENOG4105CHR reductase HUS01_01260 ENOG4105C0A alcohol dehydrogenase HUS01_01270 ENOG4105DC8 reductase HUS01_01275 ENOG4105D6S protein involved in catabolism of external DNA HUS01_01280 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HUS01_01285 ENOG4105DGW oligopeptidase A HUS01_01290 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HUS01_01295 ENOG4105DUX Transporter HUS01_01305 ENOG4108V6B universal stress protein B HUS01_01310 ENOG4105CJ3 phosphate transporter HUS01_01315 ENOG4105CBX hi0933 family HUS01_01320 ENOG4105CJW magnesium transporter HUS01_01330 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HUS01_01340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUS01_01345 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUS01_01350 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HUS01_01360 ENOG4105PY6 Phenolic acid decarboxylase HUS01_01365 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUS01_01370 ENOG4105CKK Glycosyl transferase, family 2 HUS01_01375 ENOG4105C3I Nad-dependent epimerase dehydratase HUS01_01380 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HUS01_01385 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HUS01_01390 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HUS01_01395 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HUS01_01400 ENOG4105DSF transport protein HUS01_01405 ENOG4105F9N Major Facilitator Superfamily HUS01_01410 ENOG4108W1V Lipoprotein HUS01_01415 ENOG4105EX9 Membrane HUS01_01420 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HUS01_01430 ENOG4107FS9 Membrane HUS01_01440 ENOG4105MG3 Membrane HUS01_01445 ENOG4106H78 methyltransferase HUS01_01450 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HUS01_01455 ENOG4105CAK Cell division ATP-binding protein ftsE HUS01_01460 ENOG4105CRP Part of the ABC transporter FtsEX involved in HUS01_01475 ENOG4108JPW Aminotransferase HUS01_01485 ENOG4105CP9 extracellular ligand-binding receptor HUS01_01490 ENOG4105U59 -acetyltransferase HUS01_01495 ENOG4105CP9 extracellular ligand-binding receptor HUS01_01500 ENOG4105C32 Amino acid ABC transporter (Permease) HUS01_01505 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HUS01_01510 ENOG4105C0Z ABC transporter HUS01_01515 ENOG4108IV0 ABC, transporter HUS01_01520 ENOG41060M8 Pfam:PhdYeFM HUS01_01530 ENOG4105BZ7 extracellular solute-binding protein family 1 HUS01_01535 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HUS01_01550 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HUS01_01555 ENOG4105WC8 Conserved Protein HUS01_01560 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HUS01_01565 ENOG4105WCN acetyltransferase HUS01_01575 ENOG4105D9R oxidoreductase HUS01_01580 ENOG4105C2I pirin domain protein HUS01_01585 ENOG4105DIQ Transcriptional regulator HUS01_01590 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HUS01_01595 ENOG4105C6Z Gluconate HUS01_01605 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HUS01_01610 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUS01_01615 ENOG4108IUM Glycogen debranching enzyme HUS01_01620 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HUS01_01625 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HUS01_01630 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HUS01_01645 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HUS01_01650 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HUS01_01655 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HUS01_01660 ENOG4105E98 transcriptional regulator DeoR family HUS01_01665 ENOG41061ZR Transcriptional regulator HUS01_01670 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HUS01_01675 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HUS01_01680 ENOG4105C6Z Gluconate HUS01_01685 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HUS01_01690 ENOG4105MJ2 Competence protein HUS01_01695 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HUS01_01705 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HUS01_01710 ENOG4105CE1 Ferrous iron transport protein b HUS01_01715 ENOG4105XFK Ferrous iron transport protein A HUS01_01720 ENOG4105BZM domain protein HUS01_01725 ENOG4108RRZ Transcription elongation factor GreB HUS01_01735 ENOG4105E0F Histidine kinase HUS01_01750 ENOG4105VEJ Heat shock protein HUS01_01755 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HUS01_01760 ENOG4105DQY intracellular growth attenuator HUS01_01765 ENOG4107RK2 ADP-ribose diphosphatase NudE HUS01_01770 ENOG4108JQC penicillin-binding protein 1A HUS01_01795 ENOG4105E4G Type IV pilus HUS01_01800 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HUS01_01805 ENOG4105D49 3-dehydroquinate synthase HUS01_01810 ENOG4105EGB membrane protein DamX HUS01_01815 ENOG4105DFE Dna adenine methylase HUS01_01820 ENOG4105DJV ribulose-phosphate 3-epimerase HUS01_01830 ENOG4105C31 Tryptophanyl-tRNA synthetase HUS01_01835 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUS01_01840 ENOG4105WZK nitrite reductase NADPH small subunit HUS01_01845 ENOG4107QZF nitrite reductase NADPH large subunit HUS01_01850 ENOG4105DZC cytosine deaminase HUS01_01855 ENOG4106DTQ Protein TsgA homolog HUS01_01860 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HUS01_01865 ENOG4106195 uncharacterized protein yhfG HUS01_01870 ENOG4105MZU cell filamentation protein HUS01_01880 ENOG4105C8Y Acetylornithine aminotransferase HUS01_01885 ENOG410613R integral membrane protein, YccS YhfK family HUS01_01890 ENOG4107RYR Transcriptional regulator, Crp Fnr family HUS01_01895 ENOG4108UKZ OsmC family HUS01_01900 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HUS01_01910 ENOG4105DNZ Alpha Beta Hydrolase HUS01_01915 ENOG4105C5H ABC transporter HUS01_01920 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HUS01_01925 ENOG4105CKD glutathione-regulated potassium-efflux system protein HUS01_01930 ENOG4105VKU nucleicacid-binding protein HUS01_01935 ENOG4108YZY peptidylprolyl cis-trans isomerase HUS01_01940 ENOG4105VRX Protein slyX homolog HUS01_01945 ENOG4108V1T peptidylprolyl cis-trans isomerase HUS01_01950 ENOG4105WWK YheO domain protein HUS01_01955 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HUS01_01960 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HUS01_01965 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HUS01_01970 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HUS01_01975 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HUS01_01980 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUS01_01985 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUS01_01990 ENOG4105W53 bacterioferritin-associated ferredoxin HUS01_01995 ENOG4108UQY Iron-storage protein HUS01_02010 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HUS01_02015 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HUS01_02025 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HUS01_02030 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HUS01_02035 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HUS01_02040 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HUS01_02045 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HUS01_02050 ENOG41083MP 50s ribosomal protein l29 HUS01_02055 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HUS01_02060 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HUS01_02065 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HUS01_02080 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HUS01_02085 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HUS01_02095 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HUS01_02100 ENOG4105VPB 50S ribosomal protein L30 HUS01_02105 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HUS01_02110 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HUS01_02115 ENOG41067V7 50S ribosomal protein L36 HUS01_02120 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HUS01_02125 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HUS01_02130 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUS01_02135 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUS01_02140 ENOG4108ZT0 50S ribosomal protein l17 HUS01_02145 ENOG4105VTS DnaJ-like, subfamily C HUS01_02150 ENOG4105W1Y Transcriptional regulator HUS01_02155 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HUS01_02160 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HUS01_02165 ENOG4105C1A potassium transporter peripheral membrane HUS01_02170 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HUS01_02175 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUS01_02180 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUS01_02185 ENOG4105C79 DNA protecting protein DprA HUS01_02195 ENOG4108WI1 Dna topoisomerase HUS01_02200 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUS01_02205 ENOG4105E2X shikimate dehydrogenase HUS01_02210 ENOG4105SG3 Protein of unknown function (DUF1488) HUS01_02215 ENOG4108Z0R Transferase HUS01_02245 ENOG4105XCM membrane LIPOPROTEIN HUS01_02250 ENOG4105BZS acriflavin resistance protein HUS01_02255 ENOG4105C1P efflux transporter, rnd family, mfp subunit HUS01_02260 ENOG4108XG4 DNA-binding transcriptional regulator HUS01_02265 ENOG4105DFP Integrase HUS01_02280 ENOG4105XB7 anti-repressor protein HUS01_02365 ENOG4105CAR Terminase, large subunit HUS01_02380 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HUS01_02385 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUS01_02390 ENOG4108IA2 Sodium pantothenate symporter HUS01_02395 ENOG4105RG0 Membrane HUS01_02400 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUS01_02405 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HUS01_02415 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HUS01_02430 ENOG41062P1 Diguanylate cyclase phosphodiesterase HUS01_02440 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HUS01_02445 ENOG4105VQ7 Rod shape-determining protein MreD HUS01_02450 ENOG4108Z03 MAF-like protein HUS01_02455 ENOG4105C03 ribonuclease HUS01_02460 ENOG4105QD6 exported protein HUS01_02465 ENOG4105D1U peptidase U62 modulator of DNA gyrase HUS01_02470 ENOG4105CR8 Transcriptional regulator HUS01_02485 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HUS01_02490 ENOG4105UNR (Barnase) inhibitor HUS01_02495 ENOG4105RID UPF0379 protein yhcN HUS01_02500 ENOG4105RID UPF0379 protein yhcN HUS01_02505 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HUS01_02510 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HUS01_02515 ENOG4105C0H protease HUS01_02520 ENOG4105C0H protease HUS01_02525 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HUS01_02530 ENOG4105D6Z AFG1 family ATPase HUS01_02535 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HUS01_02550 ENOG4107MKT Stringent starvation protein a HUS01_02555 ENOG4105KB2 stringent starvation protein b HUS01_02560 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HUS01_02565 ENOG4105BZ8 glutamate synthase HUS01_02570 ENOG4105CBC glutamate synthase HUS01_02575 ENOG4105N5T Radical SAM Protein HUS01_02580 ENOG4108I5G Major Facilitator superfamily HUS01_02585 ENOG4105F2I Transposase HUS01_02590 ENOG4105CPQ Dehydrogenase HUS01_02595 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HUS01_02600 ENOG4105BZU Histidine kinase HUS01_02605 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HUS01_02615 ENOG41080Z8 PHOSPHOCARRIER protein HUS01_02620 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HUS01_02625 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HUS01_02630 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HUS01_02635 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUS01_02640 ENOG4108IUZ ABC transporter HUS01_02645 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HUS01_02650 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HUS01_02655 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HUS01_02660 ENOG4105C2X Arabinose 5-phosphate isomerase HUS01_02665 ENOG4105FEU K -dependent Na -Ca exchanger HUS01_02670 ENOG4105DHJ ABC, transporter HUS01_02675 ENOG4105CY3 ABC transporter, permease HUS01_02680 ENOG4107PE3 Mammalian cell entry related domain protein HUS01_02685 ENOG4105E3I toluene tolerance HUS01_02690 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HUS01_02695 ENOG4105VFK BolA family HUS01_02700 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUS01_02705 ENOG4105HVQ Regulatory factor of maltose metabolism HUS01_02710 ENOG4105EAH synthase HUS01_02715 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HUS01_02720 ENOG4105K46 50S ribosomal protein l27 HUS01_02725 ENOG4105QYV Membrane HUS01_02730 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HUS01_02735 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HUS01_02740 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HUS01_02745 ENOG4105HBR Rna-binding protein HUS01_02750 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HUS01_02755 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HUS01_02760 ENOG4105EEI dihydropteroate synthase HUS01_02765 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HUS01_02770 ENOG4105NTZ Preprotein translocase subunit SecG HUS01_02785 ENOG4108UII YfaZ family HUS01_02790 ENOG4108PNB DNA-binding transcriptional regulator HUS01_02795 ENOG4105CDH Citrulline--aspartate ligase HUS01_02805 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HUS01_02810 ENOG4105CHV Transcription elongation factor NusA HUS01_02815 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HUS01_02820 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HUS01_02825 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HUS01_02830 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HUS01_02835 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HUS01_02850 ENOG4105C1J atp-dependent rna helicase HUS01_02855 ENOG4105CIC tryptophan-specific transport protein HUS01_02860 ENOG4105DEN Luciferase family HUS01_02880 ENOG4108YYD acetyltransferase HUS01_02885 ENOG41082IR Excinuclease ABC C subunit domain protein HUS01_02890 ENOG4108ZPB UPF0306 protein HUS01_02895 ENOG4107R7Y intracellular protease Pfpi family HUS01_02900 ENOG4105K4T epimerase HUS01_02905 ENOG4107S21 permease HUS01_02910 ENOG4105W4M Transport-associated protein HUS01_02915 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HUS01_02920 ENOG41082RQ UPF0102 protein HUS01_02925 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HUS01_02930 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HUS01_02935 ENOG4107R3N Filamentation induced by cAMP protein fic HUS01_02945 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HUS01_02950 ENOG4105DT3 PTS system, galactitol-specific IIc component HUS01_02955 ENOG41090UW PTS System HUS01_02960 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HUS01_02965 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HUS01_02970 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HUS01_02975 ENOG4105DM4 PTS System HUS01_02980 ENOG4105DE4 1-phosphofructokinase HUS01_02985 ENOG4105D2N Aldolase HUS01_02990 ENOG4105E98 transcriptional regulator DeoR family HUS01_02995 ENOG4107UEK pfkb domain protein HUS01_03000 ENOG4105CTX dehydratase HUS01_03005 ENOG4105DJB Major Facilitator Superfamily HUS01_03010 ENOG4105CNV Aldolase HUS01_03015 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HUS01_03020 ENOG4105BZW Glycerate kinase HUS01_03040 ENOG4106D80 Uncharacterized protein YhaL HUS01_03045 ENOG4108CNN domain protein HUS01_03050 ENOG4105CWB LysR family transcriptional Regulator HUS01_03055 ENOG4105KAF membrAne HUS01_03060 ENOG4105CHF Glutathione S-transferase HUS01_03065 ENOG4108VBZ doxx family HUS01_03070 ENOG4105YJD HUS01_03075 ENOG41090KG Inner membrane protein YqjE HUS01_03080 ENOG4105NE1 Conserved Protein HUS01_03085 ENOG4105WAY exported protein HUS01_03090 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HUS01_03095 ENOG4106W5V Membrane HUS01_03100 ENOG4107YCY Transcriptional regulator HUS01_03105 ENOG4105DPW Major facilitator superfamily MFS_1 HUS01_03115 ENOG4105CTX dehydratase HUS01_03120 ENOG4105P66 Membrane HUS01_03125 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HUS01_03130 ENOG4105DU1 integral membrane protein, terc HUS01_03135 ENOG4105EE0 oxidoreductase HUS01_03140 ENOG4108VKG metal-dependent hydrolase HUS01_03155 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HUS01_03160 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUS01_03165 ENOG4107RYS Autoinducer-2 (AI-2) kinase HUS01_03170 ENOG4105DKT Transcriptional regulator HUS01_03175 ENOG4105C2J ABC transporter HUS01_03180 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HUS01_03185 ENOG4105F5R ABC transporter HUS01_03190 ENOG4105D4B ABC, transporter HUS01_03195 ENOG41061GT Aldolase HUS01_03200 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HUS01_03210 ENOG4105C8Y Acetylornithine aminotransferase HUS01_03215 ENOG4105NTW Transcriptional regulator HUS01_03220 ENOG4105Q26 Siderophore-interacting protein HUS01_03235 ENOG4108UTZ Dihydroxyacetone kinase HUS01_03240 ENOG4105CMT Dihydroxyacetone kinase HUS01_03270 ENOG4105C0A alcohol dehydrogenase HUS01_03285 ENOG4105YCI dehydratase medium subunit HUS01_03290 ENOG4108ZFT Dehydratase small subunit HUS01_03295 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HUS01_03300 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUS01_03305 ENOG4105XXV Acid-resistance protein HUS01_03310 ENOG4108YK4 Acid-resistance membrane protein HUS01_03315 ENOG4108V08 YfdX protein HUS01_03320 ENOG4105BZU Histidine kinase HUS01_03325 ENOG4108WQH regulatoR HUS01_03345 ENOG4108VCA G U mismatch-specific DNA glycosylase HUS01_03350 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUS01_03355 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HUS01_03365 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUS01_03375 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HUS01_03385 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HUS01_03390 ENOG4105EQR Transposase IS116 IS110 IS902 HUS01_03400 ENOG4105KI2 Urea amidohydrolase subunit beta HUS01_03405 ENOG4108YZ9 Urea amidohydrolase subunit gamma HUS01_03410 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HUS01_03425 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HUS01_03430 ENOG4107ZVW dihydroneopterin aldolase HUS01_03435 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUS01_03440 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HUS01_03445 ENOG4106MWK domain protein HUS01_03450 ENOG4105I7R Adenylate cyclase HUS01_03455 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HUS01_03460 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HUS01_03475 ENOG4105W0Z cytoplasmic protein HUS01_03480 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUS01_03490 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HUS01_03495 ENOG4106032 Glutathionylspermidine synthase HUS01_03500 ENOG4105F1G UPF0441 protein HUS01_03510 ENOG41087AY ADP-Ribose pyrophosphatase HUS01_03515 ENOG4108SX3 cytoplasmic protein HUS01_03520 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HUS01_03525 ENOG4105IPS esterase HUS01_03530 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUS01_03535 ENOG4105VRH Antibiotic biosynthesis monooxygenase HUS01_03540 ENOG4105NF4 modulator of drug activity HUS01_03545 ENOG4105DHQ Histidine kinase HUS01_03550 ENOG4105XJC Two component transcriptional regulator (Winged helix family HUS01_03555 ENOG4105H4F exported protein HUS01_03560 ENOG4105F4I Transcriptional regulator HUS01_03565 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUS01_03570 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HUS01_03575 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HUS01_03580 ENOG4105CCT upf0313 protein HUS01_03590 ENOG4105CV8 reductase HUS01_03595 ENOG4108I6A alcohol dehydrogenase HUS01_03600 ENOG4105CF7 AraC family transcriptional regulator HUS01_03605 ENOG4108K81 inner membrane protein YghB HUS01_03610 ENOG4105C28 cystathionine HUS01_03615 ENOG4105CWK Biopolymer transport protein, ExbB HUS01_03620 ENOG4108ZZF transport protein (ExbD) HUS01_03625 ENOG4105CT4 transporter HUS01_03630 ENOG4105E4I Glycoside hydrolase family 28 HUS01_03635 ENOG4108TEB UPF0114 protein HUS01_03645 ENOG410900S Protein of unknown function (DUF2623) HUS01_03650 ENOG4105CYM Glutathione S-transferase HUS01_03665 ENOG4106032 Glutathionylspermidine synthase HUS01_03670 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUS01_03690 ENOG4105CC0 LysR family Transcriptional regulator HUS01_03695 ENOG4105C28 cystathionine HUS01_03735 ENOG4105CDU Replicative dna helicase HUS01_03910 ENOG4105F2I Transposase HUS01_03960 ENOG4105HVQ Regulatory factor of maltose metabolism HUS01_03970 ENOG4105VEQ Cold shock protein HUS01_03975 ENOG4105HVQ Regulatory factor of maltose metabolism HUS01_04020 ENOG4105MFG Antirestriction protein HUS01_04055 ENOG4108UQV Membrane HUS01_04060 ENOG4105CXN decarboxylase HUS01_04065 ENOG4105EAA nucleoside HUS01_04070 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HUS01_04075 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HUS01_04080 ENOG4105CEN a g-specific adenine glycosylase HUS01_04085 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HUS01_04090 ENOG41090ED Protein with unknown function (DUF469) HUS01_04095 ENOG4105K33 Periplasmic Protein HUS01_04100 ENOG4105CSA Coproporphyrinogen iii oxidase HUS01_04105 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HUS01_04110 ENOG4105VZ9 UPF0235 protein HUS01_04115 ENOG4108VIA integral membrane protein HUS01_04120 ENOG4105DFA alanine racemase domain protein HUS01_04125 ENOG4105CZX twitching motility protein HUS01_04130 ENOG41086KC Transcriptional regulator HUS01_04135 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HUS01_04140 ENOG4108UJU UPF0301 protein HUS01_04145 ENOG4105D7Z glutathione synthase HUS01_04150 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HUS01_04155 ENOG4105RWS endonuclease I HUS01_04160 ENOG4105GPY SprT protein HUS01_04165 ENOG4107QNK )-transporter HUS01_04170 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUS01_04190 ENOG4105CYW agmatinase HUS01_04215 ENOG4105CHR reductase HUS01_04220 ENOG4108FUF Transcriptional regulator, IclR family HUS01_04230 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HUS01_04250 ENOG4105CHR reductase HUS01_04255 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) HUS01_04270 ENOG4105J5J Outer membrane porin HUS01_04280 ENOG4108K0D peptidase, M48 HUS01_04285 ENOG4105CV1 Transketolase (EC 2.2.1.1) HUS01_04290 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUS01_04300 ENOG4105D2N Aldolase HUS01_04305 ENOG4105D64 Mechanosensitive ion channel HUS01_04310 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HUS01_04315 ENOG4105MPN Membrane HUS01_04320 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HUS01_04325 ENOG4105E66 phosphoriboisomerase A HUS01_04330 ENOG4108JQ1 Dehydrogenase HUS01_04335 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HUS01_04345 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HUS01_04350 ENOG4105E07 UPF0149 protein HUS01_04355 ENOG4107RAQ aminopeptidase HUS01_04360 ENOG4105D0A hydroxylase HUS01_04365 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HUS01_04370 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HUS01_04375 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HUS01_04380 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HUS01_04385 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUS01_04390 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUS01_04410 ENOG4105CS2 ec 3.2.1.21 HUS01_04415 ENOG4108Q3X Transcriptional regulator HUS01_04420 ENOG4105N5Z UPF0267 protein HUS01_04425 ENOG4108UT2 hemolysin iii HUS01_04435 ENOG4105Y75 tpr repeat protein HUS01_04440 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HUS01_04445 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HUS01_04450 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUS01_04455 ENOG4105T95 Thiol disulfide interChange protein HUS01_04460 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HUS01_04470 ENOG4105CRK lysyL-tRNA synthetase HUS01_04475 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HUS01_04480 ENOG4108K5P (LipO)protein HUS01_04490 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUS01_04505 ENOG4105CPC Aldo Keto reductase HUS01_04520 ENOG4105W7K Transcriptional regulator HUS01_04540 ENOG4107R5R arsenical pump membrane protein HUS01_04545 ENOG4105K89 arsenate reductase HUS01_04550 ENOG4105DUX Transporter HUS01_04555 ENOG4105V2F Uncharacterized protein yoac HUS01_04560 ENOG4105ETP RND efflux system, outer membrane lipoprotein HUS01_04565 ENOG4108MI0 Resistance protein HUS01_04570 ENOG4105J12 Multidrug resistance protein mdtN HUS01_04580 ENOG4105VR1 Pfam:DUF1271 HUS01_04585 ENOG410830R acetyltransferase HUS01_04595 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HUS01_04600 ENOG4108T65 Fimbrial HUS01_04605 ENOG4108SQA Fimbrial HUS01_04610 ENOG4105CW0 outer membrane usher protein HUS01_04615 ENOG4108NAE Fimbrial chaperone protein HUS01_04620 ENOG4108S54 Fimbrial protein HUS01_04625 ENOG4108RQP Major type 1 subunit fimbrin HUS01_04630 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HUS01_04635 ENOG4108W9T type 1 fimbriae regulatory protein HUS01_04640 ENOG4105D7X high-affinity nickel-transporter HUS01_04645 ENOG4108ZT1 Transcriptional regulator HUS01_04650 ENOG4108KTG Membrane protein, drug metabolite transporter HUS01_04660 ENOG4108T1W Fimbrial subunit type 3 HUS01_04700 ENOG4107S5I aldo keto reductase HUS01_04705 ENOG4108MHD transport protein HUS01_04715 ENOG4105C5Q Transcriptional regulator HUS01_04720 ENOG4105CHU acetyl-coa acetyltransferase HUS01_04725 ENOG4108QGT oligogalacturonate-specific porin HUS01_04730 ENOG4105CAZ oligogalacturonide lyase HUS01_04735 ENOG4105CHR reductase HUS01_04740 ENOG4107QNK )-transporter HUS01_04745 ENOG4106NDP Transcriptional regulator HUS01_04755 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HUS01_04760 ENOG4108HKT sucrose-6-phosphate hydrolase HUS01_04775 ENOG4108IJ9 (ABC) transporter HUS01_04780 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUS01_04785 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUS01_04790 ENOG4105YKW HUS01_04800 ENOG4105RQF LysR family Transcriptional regulator HUS01_04810 ENOG4105DDV Transcriptional regulator (LacI family HUS01_04815 ENOG4105CK1 PTS System HUS01_04820 ENOG4105CS2 ec 3.2.1.21 HUS01_04825 ENOG4107YCY Transcriptional regulator HUS01_04835 ENOG41060NJ transcriptional regulator HUS01_04840 ENOG4105CEY Amp-dependent synthetase and ligase HUS01_04845 ENOG4107S74 Lysophospholipid transporter LplT HUS01_04850 ENOG4105CPC Aldo Keto reductase HUS01_04855 ENOG4105SUV lipoprotein YgdR HUS01_04860 ENOG4105EE5 Membrane protein terC HUS01_04865 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) HUS01_04875 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUS01_04880 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HUS01_04885 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HUS01_04890 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HUS01_04895 ENOG4105IPU prepilin peptidase dependent protein A HUS01_04900 ENOG4105JCS prepilin peptidase dependent protein HUS01_04905 ENOG4105SEN Protein of unknown function (DUF2509) HUS01_04910 ENOG4105RVB Prepilin peptidase dependent protein c HUS01_04915 ENOG4105DSY exodeoxyribonuclease V, gamma HUS01_04920 ENOG4107QXK peptidase HUS01_04925 ENOG4107QKA exodeoxyribonuclease V beta HUS01_04930 ENOG4107QYX exodeoxyribonuclease v alpha HUS01_04940 ENOG4107QZM n-acetylglutamate synthase HUS01_04945 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HUS01_04950 ENOG4107QZB decarboxylase HUS01_04955 ENOG4105JZC GHMP kinase HUS01_04960 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HUS01_04965 ENOG4105KTW ethanolamine utilization protein HUS01_04970 ENOG4105M3W utilization protein HUS01_04980 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HUS01_04985 ENOG4105C0A alcohol dehydrogenase HUS01_04990 ENOG4108EKI Dehydrogenase HUS01_05000 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HUS01_05015 ENOG4105KNY Microcompartments protein HUS01_05020 ENOG4105KNY Microcompartments protein HUS01_05030 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HUS01_05035 ENOG4108ZFT Dehydratase small subunit HUS01_05040 ENOG4105YCI dehydratase medium subunit HUS01_05045 ENOG4105DMB glycerol dehydratase HUS01_05050 ENOG4105EHR propanediol utilization protein pduB HUS01_05055 ENOG4105KNY Microcompartments protein HUS01_05060 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUS01_05065 ENOG4107XVH Transcriptional regulator HUS01_05070 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUS01_05075 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HUS01_05080 ENOG41081F0 Precorrin-8x methylmutase HUS01_05085 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HUS01_05090 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HUS01_05095 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HUS01_05100 ENOG4105CIA precorrin-4 C(11)-methyltransferase HUS01_05105 ENOG4108P62 biosynthesis protein (CbiG) HUS01_05110 ENOG4105E4R Precorrin-3B C17-methyltransferase HUS01_05115 ENOG4105QUC reductase HUS01_05120 ENOG4107PPM cobalt chelatase HUS01_05125 ENOG4105DVK Precorrin-2 c20-methyltransferase HUS01_05130 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HUS01_05135 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HUS01_05140 ENOG4108V4M Cobalt abc transporter HUS01_05150 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUS01_05155 ENOG4108YZT Adenosylcobinamide kinase HUS01_05180 ENOG4105CA3 membrane-bound lytic murein transglycosylase HUS01_05185 ENOG4105CUZ uba thif-type nad fad binding protein HUS01_05190 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HUS01_05195 ENOG4105C9B Cysteine desulfurase HUS01_05200 ENOG4105M5B (LipO)protein HUS01_05205 ENOG4105ETT transcriptional Regulator, LysR family HUS01_05210 ENOG4105M08 Membrane HUS01_05220 ENOG4107EDW L-fucose operon activator HUS01_05225 ENOG4105NWF RbsD or FucU transport HUS01_05230 ENOG4105CMG Carbohydrate kinase HUS01_05235 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HUS01_05240 ENOG4105EDR glucose galactose transporter HUS01_05245 ENOG4107W7X Aldolase HUS01_05250 ENOG4105C0A alcohol dehydrogenase HUS01_05255 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease HUS01_05260 ENOG4108JU7 Transcriptional regulator HUS01_05270 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUS01_05285 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUS01_05290 ENOG4108UMI ABC transporter, permease HUS01_05295 ENOG4105D01 (LipO)protein HUS01_05300 ENOG41079KZ Major Facilitator Superfamily HUS01_05310 ENOG4105GVF (ABC) transporter HUS01_05315 ENOG4105EJQ L-serine dehydratase HUS01_05320 ENOG4105C44 Serine transporter HUS01_05325 ENOG4105EWT decarboxylase family HUS01_05330 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HUS01_05335 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HUS01_05340 ENOG4105WP7 tRNA pseudouridine synthase C HUS01_05345 ENOG4105DR9 pseudouridine synthase HUS01_05350 ENOG4105QDK Flavodoxin HUS01_05355 ENOG4105DJB Major Facilitator Superfamily HUS01_05360 ENOG4105EQX glucarate dehydratase HUS01_05365 ENOG4105EQX glucarate dehydratase HUS01_05370 ENOG4105BZW Glycerate kinase HUS01_05375 ENOG4105BZU Histidine kinase HUS01_05380 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUS01_05385 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUS01_05390 ENOG4105DXN mazG family HUS01_05395 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUS01_05400 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HUS01_05410 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HUS01_05415 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HUS01_05420 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HUS01_05425 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HUS01_05430 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HUS01_05435 ENOG4108MXK alkaline phosphatase isozyme conversion HUS01_05440 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUS01_05445 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HUS01_05455 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HUS01_05460 ENOG4105N0Z inner membrane protein ygbE HUS01_05465 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HUS01_05470 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HUS01_05475 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HUS01_05480 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HUS01_05490 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUS01_05495 ENOG4108K5P (LipO)protein HUS01_05500 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUS01_05525 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HUS01_05530 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HUS01_05535 ENOG4105KZM cytoplasmic protein HUS01_05545 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HUS01_05565 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUS01_05570 ENOG4105EHG Permease protein HUS01_05575 ENOG4107R4I Periplasmic binding protein HUS01_05580 ENOG4106QJH hemin transport protein HUS01_05600 ENOG4108N2Y auxin Efflux HUS01_05610 ENOG4105VXR cytoplasmic protein HUS01_05615 ENOG4105CC5 ABC transporter HUS01_05620 ENOG4105CC5 ABC transporter HUS01_05625 ENOG4105DIK (ABC) transporter HUS01_05630 ENOG4105DSE periplasmic solute binding protein HUS01_05635 ENOG4105DDV Transcriptional regulator (LacI family HUS01_05640 ENOG4105DKQ ROK family HUS01_05645 ENOG4105VCP PTS System HUS01_05650 ENOG4105CK1 PTS System HUS01_05655 ENOG4105VZJ PTS System HUS01_05660 ENOG4105CK1 PTS System HUS01_05665 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HUS01_05675 ENOG4105CS2 ec 3.2.1.21 HUS01_05685 ENOG4105C45 hydrogenase expression formation protein (HypE) HUS01_05690 ENOG4105CQS hydrogenase expression formation protein HypD HUS01_05695 ENOG41083WG hydrogenase assembly chaperone HUS01_05700 ENOG4107RSS Hydrogenase accessory protein HypB HUS01_05705 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HUS01_05710 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HUS01_05715 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HUS01_05720 ENOG4107R30 NADH dehydrogenase HUS01_05725 ENOG4107TDF Formate hydrogenlyase subunit 4 HUS01_05730 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUS01_05735 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HUS01_05740 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HUS01_05745 ENOG4105I6X formate hydrogenlyase maturation HUS01_05750 ENOG4108MG9 hydrogenase 3 maturation protease HUS01_05760 ENOG4105CS2 ec 3.2.1.21 HUS01_05765 ENOG4105C5Y PTS System HUS01_05770 ENOG4105DDV Transcriptional regulator (LacI family HUS01_05775 ENOG4108RC0 Electron transport protein HUS01_05780 ENOG4105C8H hydrogenase maturation protein Hypf HUS01_05790 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HUS01_05795 ENOG4105CNW domain protein HUS01_05800 ENOG4108JUA Transcriptional regulator HUS01_05810 ENOG410804X Transcriptional regulator HUS01_05815 ENOG4105J92 DNA-binding transcriptional activator GutM HUS01_05820 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HUS01_05825 ENOG4105VI0 Pts system, glucitol sorbitol-specific HUS01_05830 ENOG4105DZY Pts system, glucitol sorbitol-specific HUS01_05835 ENOG410787A Pts system, glucitol sorbitol-specific HUS01_05840 ENOG4105CVE Lytic murein transglycosylase HUS01_05850 ENOG4105CC5 ABC transporter HUS01_05855 ENOG4105DSE periplasmic solute binding protein HUS01_05860 ENOG4107TH8 cina domain protein HUS01_05865 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUS01_05870 ENOG4105Y3E Modulates RecA activity (By similarity) HUS01_05875 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUS01_05880 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HUS01_05910 ENOG4105K3G Periplasmic Protein HUS01_05915 ENOG4107VXZ Hydrolase HUS01_05920 ENOG4105W39 Membrane HUS01_05925 ENOG4105D9M gamma-glutamylcysteine synthetase HUS01_05940 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUS01_05945 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUS01_05950 ENOG4105CW7 secretion protein, HlyD family HUS01_05955 ENOG4105NTK Transcriptional repressor Mpra HUS01_05960 ENOG4105ZED uncharacterized protein ygaH HUS01_05965 ENOG4108UMN azlc family HUS01_05970 ENOG4105GIJ Glycine betaine HUS01_05975 ENOG4108HQS Glycine betaine HUS01_05980 ENOG4108IJ7 Glycine betaine HUS01_05985 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUS01_05990 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUS01_05995 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HUS01_06000 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HUS01_06005 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUS01_06010 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUS01_06015 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HUS01_06020 ENOG4108WMJ Protein of unknown function (DUF2002) HUS01_06025 ENOG4108RNS Exports L-alanine (By similarity) HUS01_06030 ENOG4108X73 DNA- binding protein HUS01_06045 ENOG4108V62 Rhodanese domain protein HUS01_06050 ENOG41080HT Transcriptional regulator, arsr family HUS01_06060 ENOG4105CC0 LysR family Transcriptional regulator HUS01_06065 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HUS01_06070 ENOG4105C26 Dehydrogenase HUS01_06080 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUS01_06115 ENOG4105KSC Transcriptional regulator, TraR DksA family HUS01_06120 ENOG4105DFE Dna adenine methylase HUS01_06130 ENOG4105EKQ RNA-directed DNA polymerase HUS01_06165 ENOG4105ED4 portal protein HUS01_06315 ENOG4105ZTC transcriptional activator, Ogr delta HUS01_06330 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUS01_06335 ENOG4108Z1B Cyclase dehydrase HUS01_06345 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HUS01_06350 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HUS01_06355 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUS01_06360 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HUS01_06365 ENOG4108JU6 CBS domain protein HUS01_06370 ENOG4106KVJ cytochrome C assembly protein HUS01_06375 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HUS01_06380 ENOG4105K5M 30s ribosomal protein S16 HUS01_06385 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HUS01_06390 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HUS01_06395 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HUS01_06410 ENOG41090EK ompa motb domain protein HUS01_06415 ENOG4108KHX Diguanylate cyclase HUS01_06420 ENOG4108WS1 HUS01_06425 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HUS01_06430 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HUS01_06440 ENOG4105CQC Prephenate dehydratase HUS01_06450 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HUS01_06455 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HUS01_06460 ENOG4105C34 Pseudouridine synthase HUS01_06465 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HUS01_06470 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUS01_06495 ENOG4105CSH Transporter HUS01_06500 ENOG4105T42 (LipO)protein HUS01_06505 ENOG4105JIM Phosphatidylserine synthase HUS01_06510 ENOG4105CD5 CoA-binding domain protein HUS01_06515 ENOG4106IUH DTW domain containing protein HUS01_06520 ENOG4105K63 Thioredoxin HUS01_06525 ENOG4105EIB trna rrna methyltransferase HUS01_06530 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUS01_06535 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HUS01_06540 ENOG4105C1J atp-dependent rna helicase HUS01_06545 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HUS01_06550 ENOG4108IYU L-aspartate oxidase HUS01_06565 ENOG41069PW sigma-e factor negative regulatory protein HUS01_06570 ENOG4105VQK sigma E regulatory protein, MucB RseB HUS01_06575 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HUS01_06580 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HUS01_06585 ENOG4105C3F Signal peptidase i HUS01_06590 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HUS01_06595 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HUS01_06600 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HUS01_06605 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HUS01_06610 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HUS01_06615 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HUS01_06620 ENOG4106G6Q Transcriptional regulator HUS01_06625 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HUS01_06630 ENOG4108Z6B deaminase HUS01_06635 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HUS01_06640 ENOG4108ETH Formylglycinamide ribotide synthetase HUS01_06645 ENOG4107WP9 Histidine kinase HUS01_06650 ENOG4108SKK alpha helix protein HUS01_06655 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HUS01_06660 ENOG4108YZA Nitrogen regulatory protein pii HUS01_06665 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUS01_06670 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUS01_06675 ENOG4108SB3 DoxX Family HUS01_06680 ENOG4108NZE NAGC-like transcriptional regulator HUS01_06685 ENOG4107HQ7 repeat protein HUS01_06690 ENOG4107QNK )-transporter HUS01_06695 ENOG4108ZKT aldose 1-epimerase HUS01_06700 ENOG4105D8G Major Facilitator superfamily HUS01_06705 ENOG4108MN2 Stationary phase inducible protein CsiE HUS01_06710 ENOG41065CD Exported protein HUS01_06715 ENOG4105D7X high-affinity nickel-transporter HUS01_06730 ENOG4105ECY inositol monophosphatase HUS01_06735 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HUS01_06740 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HUS01_06745 ENOG4105C3J Cysteine desulfurase HUS01_06750 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HUS01_06755 ENOG4108Z4V iron-sulfur cluster assembly HUS01_06760 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HUS01_06765 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HUS01_06770 ENOG4108ZIT Ferredoxin, 2FE-2S HUS01_06775 ENOG4105WVQ Fe-S assembly protein IscX HUS01_06780 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUS01_06785 ENOG4105YYA enhanced serine sensitivity protein SseB HUS01_06795 ENOG4105KHC sulfurtransferase HUS01_06800 ENOG4105DN3 alpha-2-macroglobulin domain protein HUS01_06805 ENOG4108JQB penicillin-binding protein 1C HUS01_06810 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUS01_06815 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HUS01_06820 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HUS01_06825 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUS01_06835 ENOG4105N21 Membrane HUS01_06840 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HUS01_06845 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HUS01_06855 ENOG4105VPD cellular component movement HUS01_06860 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUS01_06865 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HUS01_06870 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUS01_06915 ENOG41076J9 exonuclease VIII HUS01_07000 ENOG4105KT5 UmuD protein HUS01_07005 ENOG4108TFU terminase (Small subunit) HUS01_07105 ENOG4105WXW Antirepressor HUS01_07135 ENOG4105NVB glycoside hydrolase, family 19 HUS01_07150 ENOG4105C4X radical SAM domain protein HUS01_07165 ENOG41062G3 Protein of unknown function (DUF2633) HUS01_07170 ENOG4105BZU Histidine kinase HUS01_07175 ENOG4105C9X ppx gppa phosphatase HUS01_07180 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HUS01_07185 ENOG4108V3E phosphoribosylglycinamide formyltransferase HUS01_07190 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUS01_07195 ENOG41066F8 ROK family HUS01_07200 ENOG4105CS2 ec 3.2.1.21 HUS01_07205 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HUS01_07210 ENOG4105C2W permease HUS01_07215 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HUS01_07225 ENOG4105K89 arsenate reductase HUS01_07230 ENOG4105ERG peptidase m48, ste24p HUS01_07240 ENOG4105C02 permease HUS01_07245 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUS01_07250 ENOG4105RH4 Glycine cleavage system transcriptional repressor HUS01_07255 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUS01_07260 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HUS01_07265 ENOG4105C8V SAICAR synthetase HUS01_07270 ENOG4105CGZ zinc metallopeptidase HUS01_07275 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HUS01_07280 ENOG4106KED esterase YpfH HUS01_07285 ENOG4105XYK UPF0370 protein HUS01_07290 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUS01_07295 ENOG4105KUZ arsenate reductase HUS01_07305 ENOG4105BZS acriflavin resistance protein HUS01_07310 ENOG4105BZ8 glutamate synthase HUS01_07315 ENOG4107VIJ nudix hydrolase HUS01_07320 ENOG4108PVD exported protein HUS01_07325 ENOG4105CV1 Transketolase (EC 2.2.1.1) HUS01_07330 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HUS01_07335 ENOG4105C6K Malic enzyme HUS01_07340 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HUS01_07345 ENOG4106S4J ethanolamine utilization protein EutP HUS01_07350 ENOG4105NDK ethanolamine utilization protein HUS01_07355 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HUS01_07360 ENOG4108IJ2 phosphate acetyltransferase HUS01_07365 ENOG4105KNY Microcompartments protein HUS01_07370 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HUS01_07375 ENOG4108EKI Dehydrogenase HUS01_07380 ENOG4107YMV ethanolamine utilization protein HUS01_07385 ENOG4105C0A alcohol dehydrogenase HUS01_07390 ENOG4105ENY Ethanolamine utilization protein eutH HUS01_07395 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HUS01_07400 ENOG4105CPD ethanolamine ammonia-lyase HUS01_07410 ENOG4106D67 ethanolamine utilization protein HUS01_07415 ENOG4108X49 Ethanolamine utilization protein EutK HUS01_07420 ENOG4108K3Z AraC family transcriptional regulator HUS01_07425 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HUS01_07430 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HUS01_07435 ENOG4108R6G acetyltransferase HUS01_07440 ENOG4105QZU Inner membrane protein YfeZ HUS01_07445 ENOG4105E7K (LipO)protein HUS01_07450 ENOG4105EZR dyp-type peroxidase family protein HUS01_07460 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HUS01_07465 ENOG4108I5D sulfate abc transporter HUS01_07470 ENOG4105ECW sulfate abc transporter HUS01_07475 ENOG4108IJ6 ABC transporter HUS01_07480 ENOG4105C6T cysteine synthase HUS01_07485 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HUS01_07490 ENOG4105CSW GntR family transcriptional regulator HUS01_07495 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HUS01_07505 ENOG4105C5Y PTS System HUS01_07510 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HUS01_07515 ENOG4105KZ7 phosphocarrier protein hpr HUS01_07520 ENOG4105C6T cysteine synthase HUS01_07525 ENOG4105EXN Sulfate transport protein CysZ HUS01_07530 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HUS01_07535 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUS01_07540 ENOG4105VRT cytoplasmic protein HUS01_07545 ENOG4105DHU Bile acid HUS01_07550 ENOG4108M0I Transcriptional regulator HUS01_07575 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HUS01_07580 ENOG4105GXM Putative transcription regulator (DUF1323) HUS01_07585 ENOG4105HZG regulatoR HUS01_07600 ENOG4108KMM Diguanylate cyclase HUS01_07605 ENOG4105D9N nucleoside HUS01_07610 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HUS01_07615 ENOG4109076 Conserved Protein HUS01_07620 ENOG4105CPC Aldo Keto reductase HUS01_07625 ENOG4107RA9 decarboxylase HUS01_07635 ENOG4105CHC glucokinase (EC 2.7.1.2) HUS01_07640 ENOG4105DY9 regulatoR HUS01_07645 ENOG4108HRK Histidine kinase HUS01_07660 ENOG4105CHM Aminotransferase HUS01_07670 ENOG4105DJ2 Major Facilitator Superfamily HUS01_07675 ENOG4107Y2X deaminase HUS01_07680 ENOG4105DND Transcriptional regulator HUS01_07700 ENOG4105S64 Formate nitrite transporter HUS01_07705 ENOG410903C (LipO)protein HUS01_07710 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HUS01_07715 ENOG4105KZW UPF0381 protein HUS01_07720 ENOG4105CHU acetyl-coa acetyltransferase HUS01_07725 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUS01_07730 ENOG4108BY2 phosphohistidine phosphatase HUS01_07735 ENOG4108DG9 Smr protein MutS2 HUS01_07740 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HUS01_07745 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HUS01_07750 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HUS01_07755 ENOG4105EJ9 Membrane HUS01_07760 ENOG4108BPE -transporting atpase HUS01_07765 ENOG4105MH2 YfcL protein HUS01_07770 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HUS01_07775 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUS01_07780 ENOG4105F9N Major Facilitator Superfamily HUS01_07785 ENOG4106WZ1 flagella biosynthesis regulator HUS01_07795 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HUS01_07800 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HUS01_07805 ENOG4105DQR SNARE associated Golgi HUS01_07810 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HUS01_07815 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HUS01_07820 ENOG4108S3P Sporulation domain protein HUS01_07825 ENOG4105E96 Colicin v production protein HUS01_07830 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HUS01_07835 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HUS01_07845 ENOG4105E89 ABC transporter HUS01_07850 ENOG4105E89 ABC transporter HUS01_07855 ENOG4105DSP amino acid AbC transporter HUS01_07860 ENOG4106YG3 ABC transporter HUS01_07865 ENOG4108JEH abc transporter atp-binding protein HUS01_07870 ENOG4105KNA -acetyltransferase HUS01_07880 ENOG4105ECP epimerase HUS01_07885 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HUS01_07890 ENOG4105CYM Glutathione S-transferase HUS01_07895 ENOG4108SHQ Glutathione S-transferase HUS01_07900 ENOG4108RE9 Phosphodiesterase HUS01_07905 ENOG4105PTV Nudix Hydrolase HUS01_07910 ENOG4105C6K Malic enzyme HUS01_07915 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HUS01_07920 ENOG4105PQ6 UPF0208 membrane protein HUS01_07930 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HUS01_07935 ENOG4107QWE )-transporter HUS01_07940 ENOG4105DK2 UPF0207 protein HUS01_07945 ENOG4105CHM Aminotransferase HUS01_07950 ENOG4107NQ8 LysR family Transcriptional regulator HUS01_07955 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUS01_07960 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUS01_07965 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUS01_07970 ENOG4105GKE subunit e HUS01_07975 ENOG4107QIZ NADH dehydrogenase HUS01_07980 ENOG4108IEH NADH dehydrogenase subunit g HUS01_07985 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUS01_07995 ENOG4107UFS subunit j HUS01_08000 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUS01_08005 ENOG4105D65 subunit l HUS01_08010 ENOG4105C8S subunit m HUS01_08015 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUS01_08020 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUS01_08025 ENOG4107YB6 acetyltransferase, (GNAT) family HUS01_08030 ENOG4105E4F Isochorismate synthase HUS01_08035 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HUS01_08040 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HUS01_08045 ENOG4108IPT Naphthoate synthase HUS01_08050 ENOG4105DNI Converts SHCHC to OSB (By similarity) HUS01_08055 ENOG4105CEY Amp-dependent synthetase and ligase HUS01_08065 ENOG4105DNE Transposase HUS01_08070 ENOG4108UII YfaZ family HUS01_08075 ENOG4108EWA cinA-like protein HUS01_08080 ENOG4107258 Transcriptional regulator HUS01_08085 ENOG4105CXK mandelate racemase muconate lactonizing HUS01_08090 ENOG4105CSP Major Facilitator Superfamily HUS01_08095 ENOG4105CNV Aldolase HUS01_08100 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HUS01_08105 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HUS01_08110 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HUS01_08115 ENOG4105CXY transporter HUS01_08120 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HUS01_08125 ENOG4105XPH Ferredoxin HUS01_08130 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUS01_08135 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUS01_08140 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUS01_08145 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUS01_08150 ENOG4105BZU Histidine kinase HUS01_08155 ENOG41068CG regulatoR HUS01_08160 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HUS01_08175 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUS01_08180 ENOG4105CF1 Alkylated DNA repair protein HUS01_08185 ENOG4105IBP Cyclic peptide transporter HUS01_08190 ENOG4105CJW magnesium transporter HUS01_08195 ENOG4105CHH sulfate transporter HUS01_08210 ENOG4105F4G Membrane HUS01_08220 ENOG4105E68 Sulfatase HUS01_08225 ENOG4105PAN UPF0352 protein HUS01_08230 ENOG4106V8H Nucleoid-associated protein HUS01_08235 ENOG4105E98 transcriptional regulator DeoR family HUS01_08240 ENOG4107VIJ nudix hydrolase HUS01_08255 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HUS01_08260 ENOG4105CFI type iii restriction protein res subunit HUS01_08265 ENOG4105I08 Pseudouridine synthase HUS01_08270 ENOG4105C2C drug resistance transporter, Bcr CflA HUS01_08275 ENOG4105HG6 HUS01_08280 ENOG4108JQ5 ABC transporter HUS01_08285 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HUS01_08290 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HUS01_08295 ENOG4105E43 Extracellular solute-binding protein, family 5 HUS01_08300 ENOG4105CXC rtn protein HUS01_08305 ENOG4107TT5 NLP P60 protein HUS01_08310 ENOG41076MN Phosphoesterase, PA-phosphatase related HUS01_08315 ENOG4105CKI cobalamin synthesis protein HUS01_08320 ENOG4105DEI Mannitol dehydrogenase HUS01_08325 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HUS01_08335 ENOG4105KRS Proteinase inhibitor HUS01_08345 ENOG4105S8Q sugar efflux transporter HUS01_08350 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HUS01_08355 ENOG4105DE4 1-phosphofructokinase HUS01_08360 ENOG4105DM4 PTS System HUS01_08365 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HUS01_08370 ENOG4105HMI Membrane HUS01_08375 ENOG4105DUM transcriptional regulator, lysR family HUS01_08380 ENOG4108IQI permease HUS01_08390 ENOG4105D05 Receptor HUS01_08400 ENOG4105EUJ GTP cyclohydrolase i HUS01_08405 ENOG4105DHF Membrane HUS01_08410 ENOG41060NJ transcriptional regulator HUS01_08420 ENOG4105C2J ABC transporter HUS01_08425 ENOG4107SDZ Galactoside transport system permease protein mglC HUS01_08430 ENOG4107GZ4 SanA protein HUS01_08435 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HUS01_08440 ENOG41067MG lrgb family HUS01_08445 ENOG4105VAW lrga family HUS01_08450 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HUS01_08455 ENOG4105TW1 Carbohydrate-selective porin OprB HUS01_08470 ENOG4105CS2 ec 3.2.1.21 HUS01_08480 ENOG4105KHU inner membrane protein YohD HUS01_08485 ENOG41069YE inner membrane protein yohC HUS01_08490 ENOG41061WM D-Alanyl-D-Alanine HUS01_08505 ENOG4105CXG d-lactate dehydrogenase HUS01_08510 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUS01_08515 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HUS01_08520 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HUS01_08525 ENOG4108IJ8 ABC transporter HUS01_08530 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HUS01_08540 ENOG4108HRK Histidine kinase HUS01_08545 ENOG4108NEV two component transcriptional regulator, LytTR family HUS01_08550 ENOG4108W15 Protein of unknown function (DUF1456) HUS01_08555 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HUS01_08560 ENOG4105D1F ATP-binding protein HUS01_08570 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HUS01_08575 ENOG4105EJC lysr family transcriptional regulator HUS01_08580 ENOG4105C7N Xanthine uracil vitamin C permease HUS01_08585 ENOG4105CPN adenine deaminase HUS01_08590 ENOG4105DUM transcriptional regulator, lysR family HUS01_08605 ENOG4105DWF phosphomethylpyrimidine kinase HUS01_08610 ENOG4105EIE fructose-bisphosphate aldolase HUS01_08615 ENOG4105IE8 Alpha-ketoglutarate permease HUS01_08640 ENOG4105DEI Mannitol dehydrogenase HUS01_08645 ENOG4105CMG Carbohydrate kinase HUS01_08650 ENOG4105IE8 Alpha-ketoglutarate permease HUS01_08655 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HUS01_08660 ENOG4105CXK mandelate racemase muconate lactonizing HUS01_08665 ENOG4105DEF Extracellular solute-binding protein, family 5 HUS01_08670 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUS01_08675 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUS01_08685 ENOG4108JQ7 (ABC) transporter HUS01_08695 ENOG4105CFP Peptidase U32 HUS01_08700 ENOG4105E3W Two component transcriptional regulator (Winged helix family HUS01_08705 ENOG4105EB3 Histidine kinase HUS01_08710 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUS01_08715 ENOG4105BZS acriflavin resistance protein HUS01_08720 ENOG4105BZS acriflavin resistance protein HUS01_08725 ENOG4105ENT Efflux transporter rnd family, mfp subunit HUS01_08730 ENOG4105CK2 sodium dicarboxylate symporter HUS01_08750 ENOG4105BZU Histidine kinase HUS01_08755 ENOG4105R8A Heat shock protein HUS01_08760 ENOG4105D03 DNA-3-methyladenine glycosylase II HUS01_08765 ENOG4105DBI uridine monophosphokinase HUS01_08770 ENOG4105DHP deoxycytidine triphosphate deaminase HUS01_08775 ENOG4108GAE asmA family HUS01_08780 ENOG4105EE5 Membrane protein terC HUS01_08785 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUS01_08790 ENOG4105MH5 phosphoesterase PA-phosphatase related protein HUS01_08800 ENOG4108MRJ HUS01_08805 ENOG4105DAY polysaccharide export protein HUS01_08850 ENOG4107T8Q Glycosyl transferase (Group 1 HUS01_08870 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HUS01_08885 ENOG4105C1B dTDP-glucose 4-6-dehydratase HUS01_08895 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HUS01_08900 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HUS01_08910 ENOG4105F2I Transposase HUS01_08960 ENOG4105CPK Glycosyl transferase (Group 1 HUS01_08970 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUS01_08975 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HUS01_08985 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HUS01_08990 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HUS01_08995 ENOG4105CIH Imidazole acetol-phosphate transaminase HUS01_09005 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HUS01_09015 ENOG4107SRH Nad-dependent epimerase dehydratase HUS01_09020 ENOG4105EQ1 Transcriptional regulator HUS01_09030 ENOG4105CUB amino acid HUS01_09035 ENOG4105YVS arsR family transcriptional regulator HUS01_09040 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUS01_09050 ENOG4105CJB Exodeoxyribonuclease I HUS01_09055 ENOG4105DZ1 carboxypeptidase HUS01_09060 ENOG4105EKQ RNA-directed DNA polymerase HUS01_09070 ENOG4105DR8 Membrane HUS01_09075 ENOG41090HJ UPF0265 protein HUS01_09080 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HUS01_09085 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUS01_09090 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HUS01_09100 ENOG41090U3 tautomerase HUS01_09105 ENOG4105HEI LysR family (Transcriptional regulator HUS01_09110 ENOG4108KMH lipoate-protein ligase a HUS01_09115 ENOG4105CSH Transporter HUS01_09125 ENOG4105BZU Histidine kinase HUS01_09135 ENOG4108YS1 cytoplasmic protein HUS01_09140 ENOG4105YP6 Domain of unknown function (DUF1869) HUS01_09145 ENOG4105ETT transcriptional Regulator, LysR family HUS01_09160 ENOG4105BZU Histidine kinase HUS01_09210 ENOG4105W5Q DNA repair protein (RadC HUS01_09255 ENOG4108PCE TRANSFER protein HUS01_09280 ENOG4106D0Q Type IV secretion system protein VirB2 HUS01_09325 ENOG4107ZSV Receptor HUS01_09330 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUS01_09350 ENOG4105C0W non-ribosomal peptide synthetase HUS01_09365 ENOG4105BZ1 (ABC) transporter HUS01_09370 ENOG4105EYM Major Facilitator superfamily HUS01_09390 ENOG4105UQX Mate efflux family protein HUS01_09400 ENOG4105FYV Amp nucleosidase HUS01_09420 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HUS01_09430 ENOG4105EEQ Na H antiporter HUS01_09445 ENOG4107R11 Transcriptional regulator HUS01_09450 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HUS01_09465 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HUS01_09475 ENOG4105FCK Membrane HUS01_09480 ENOG4105Y0K Inner membrane protein YedR HUS01_09485 ENOG4105EST Metal Dependent Phosphohydrolase HUS01_09490 ENOG4105DVF Cytosine-specific methyltransferase HUS01_09495 ENOG41090BB DNA mismatch endonuclease (vsr) HUS01_09500 ENOG4105FDR Membrane HUS01_09505 ENOG4105CKW Inner membrane protein yedI HUS01_09515 ENOG4105YX3 cellular response to acidity HUS01_09530 ENOG4105JCU Inherit from NOG: (Lipo)protein HUS01_09535 ENOG4105E5K Alpha-amylase HUS01_09540 ENOG4105EAB amino acid AbC transporter HUS01_09545 ENOG4105K6H D-cysteine desulfhydrase HUS01_09550 ENOG4105E5Q amino acid AbC transporter HUS01_09555 ENOG4105CDA abc transporter atp-binding protein HUS01_09560 ENOG4105VJY transcriptional regulator HUS01_09565 ENOG4105XVG cytoplasmic protein HUS01_09570 ENOG4105WH1 Two component transcriptional regulator luxr family HUS01_09605 ENOG4106RHG Yeca family HUS01_09610 ENOG4105E0U tyrosine-specific transport protein HUS01_09615 ENOG4105VVZ metal-binding protein HUS01_09620 ENOG41090A1 ferritin HUS01_09635 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUS01_09640 ENOG4105N4N Protein of unknown function (DUF2766) HUS01_09655 ENOG4108UEC Ferritin-like protein HUS01_09665 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HUS01_09675 ENOG4105CNN ABC, transporter HUS01_09685 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HUS01_09690 ENOG4108VA4 Universal stress protein HUS01_09695 ENOG4105CT4 transporter HUS01_09700 ENOG4105F5H Glycosyl Hydrolase Family 88 HUS01_09705 ENOG4105C75 arginyL-tRNA synthetase HUS01_09710 ENOG4106ZCM YecM protein HUS01_09715 ENOG4106N3A copper homeostasis protein cutc HUS01_09720 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HUS01_09725 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HUS01_09730 ENOG4105WJG Glutathione HUS01_09735 ENOG41081XQ Conserved Protein HUS01_09740 ENOG4105D3W isochorismatase HUS01_09745 ENOG4105C9M aspartyl-trna synthetase HUS01_09750 ENOG4108TIT dATP pyrophosphohydrolase HUS01_09755 ENOG4105CDY transcriptional regulatory protein HUS01_09760 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HUS01_09765 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HUS01_09770 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUS01_09775 ENOG4105FAV ABC, transporter HUS01_09785 ENOG4105NXV High-affinity zinc uptake system protein HUS01_09790 ENOG4105DR5 peptidase HUS01_09795 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HUS01_09800 ENOG4105CA9 Pyruvate kinase HUS01_09805 ENOG4106KNT transcriptional regulator HUS01_09815 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HUS01_09820 ENOG4105C01 Dihydroxy-acid dehydratase HUS01_09825 ENOG4108UHU Aldolase HUS01_09835 ENOG4105X2V dna damage-inducible protein HUS01_09840 ENOG4108Q2J Inner membrane protein YebE HUS01_09845 ENOG4105CUG Oligopeptidase b HUS01_09850 ENOG4105UMD exodeoxyribonuclease X HUS01_09855 ENOG4105MPK DNA polymerase III subunit theta HUS01_09860 ENOG4105FXM Copper resistance protein HUS01_09865 ENOG4108PNC copper resistance HUS01_09870 ENOG4105NKT exported protein HUS01_09880 ENOG4108MJ5 VirK protein HUS01_09885 ENOG4108R1E Serine threonine protein phosphatase 1 HUS01_09890 ENOG4105UVW uncharacterized protein yebW HUS01_09895 ENOG4105WT8 Protein of unknown function (DUF1480) HUS01_09900 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HUS01_09905 ENOG4105DY2 Paraquat-inducible protein b HUS01_09910 ENOG4105H2K paraquat-inducible protein a HUS01_09915 ENOG4108ZGC gaf domain protein HUS01_09920 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HUS01_09925 ENOG4105CN1 protease HUS01_09930 ENOG4105D0M Protease HtpX homolog HUS01_09935 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUS01_09940 ENOG4105J4Q Transcriptional regulator HUS01_09945 ENOG4105TIK HUS01_09955 ENOG4105Q3Y exported protein HUS01_09970 ENOG4105CJN penicillin-binding protein HUS01_09975 ENOG4105DHI Methyltransferase HUS01_09980 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HUS01_09985 ENOG4108NK4 UPF0266 membrane protein HUS01_09990 ENOG4105F3R pts system mannose fructose sorbose family iid HUS01_09995 ENOG4105ETZ PTS System HUS01_10000 ENOG4105DAS pts system HUS01_10005 ENOG4105EE5 Membrane protein terC HUS01_10010 ENOG4107XTP (EAL) domain protein HUS01_10015 ENOG4105EJQ L-serine dehydratase HUS01_10020 ENOG4105P8F nudix hydrolase HUS01_10030 ENOG4105X5C UPF0181 protein HUS01_10035 ENOG4105M4H endoribonuclease L-psp HUS01_10040 ENOG4105DVT helicase HUS01_10045 ENOG41072GX Peptidase M22 Glycoprotease HUS01_10050 ENOG4105Y4Z Outer Membrane Lipoprotein HUS01_10055 ENOG4105CEY Amp-dependent synthetase and ligase HUS01_10060 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HUS01_10065 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HUS01_10070 ENOG4107QMS site-determining protein HUS01_10075 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HUS01_10080 ENOG4105VNG YcgL domain-containing protein HUS01_10085 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HUS01_10090 ENOG4108ZZ3 UPF0260 protein HUS01_10100 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HUS01_10105 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUS01_10110 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) HUS01_10115 ENOG4105ED1 spovr family HUS01_10125 ENOG4105MWK D-amino acid dehydrogenase, small subunit HUS01_10135 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HUS01_10140 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HUS01_10145 ENOG4106JQ5 Transglycosylase SLT domain HUS01_10150 ENOG4105E0K tonB-dependent siderophore receptor HUS01_10205 ENOG410811B TRANSCRIPTIONal HUS01_10210 ENOG4105C7B Threonine dehydratase HUS01_10215 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HUS01_10225 ENOG4105C6N Formate acetyltransferase HUS01_10240 ENOG4105C32 Amino acid ABC transporter (Permease) HUS01_10245 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HUS01_10250 ENOG4105C0Z ABC transporter HUS01_10255 ENOG4108IV0 ABC, transporter HUS01_10260 ENOG4107YNJ LysR family Transcriptional regulator HUS01_10280 ENOG4105CSH Transporter HUS01_10290 ENOG4105F04 LysR family Transcriptional regulator HUS01_10300 ENOG4105D3G Pseudouridine synthase HUS01_10305 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HUS01_10325 ENOG4108ZG0 Ompa motb domain protein HUS01_10335 ENOG4105CS6 Rhs element vgr protein HUS01_10460 ENOG4105C3G gtp-binding protein HUS01_10465 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HUS01_10470 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HUS01_10480 ENOG4105CHH sulfate transporter HUS01_10485 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HUS01_10490 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HUS01_10500 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HUS01_10505 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HUS01_10510 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUS01_10515 ENOG4108YY7 Invasion gene expression up-regulator SirB HUS01_10520 ENOG41063JG Transcriptional regulator HUS01_10525 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HUS01_10530 ENOG4105EWV Sodium calcium exchanger membrane region HUS01_10535 ENOG4105WS7 Cation transport regulator HUS01_10540 ENOG4108NH8 Cation transport protein HUS01_10550 ENOG41090EX DsrE family HUS01_10560 ENOG4105I5W Transporter HUS01_10570 ENOG4105D7T ABC transporter HUS01_10575 ENOG4107QZF nitrite reductase NADPH large subunit HUS01_10585 ENOG4105ID0 Putative invasin HUS01_10590 ENOG4105WH1 Two component transcriptional regulator luxr family HUS01_10595 ENOG4105BZU Histidine kinase HUS01_10600 ENOG4105DQQ Major facilitator superfamily MFS_1 HUS01_10610 ENOG4105CRU nitrate reductase, alpha subunit HUS01_10615 ENOG4108IUE nitrate reductase beta subunit HUS01_10620 ENOG4105R3A Nitrate reductase HUS01_10625 ENOG41076YT nitrate reductase, gamma subunit HUS01_10670 ENOG4105CIY formyltetrahydrofolate deformylase HUS01_10680 ENOG4105D78 K07001 NTE family protein HUS01_10685 ENOG4105I93 response regulator HUS01_10690 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUS01_10705 ENOG4107104 thymidine kinase HUS01_10710 ENOG4105C0A alcohol dehydrogenase HUS01_10720 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HUS01_10725 ENOG4108J59 Extracellular solute-binding protein, family 5 HUS01_10730 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUS01_10735 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUS01_10740 ENOG4105C3U ABC transporter HUS01_10745 ENOG4108JQ7 (ABC) transporter HUS01_10750 ENOG4105EYW Ion transport protein HUS01_10755 ENOG4108W5H UPF0263 protein HUS01_10760 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HUS01_10770 ENOG4108YYC ycei family HUS01_10780 ENOG4105K9H YciI-like protein HUS01_10785 ENOG410822N TonB family HUS01_10795 ENOG4105P10 Uncharacterized protein ydiZ HUS01_10800 ENOG4105DE4 1-phosphofructokinase HUS01_10805 ENOG4108NE3 Salt-induced outer membrane protein HUS01_10820 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HUS01_10825 ENOG41082NX 50s ribosomal protein l35 HUS01_10840 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HUS01_10845 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HUS01_10850 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HUS01_10860 ENOG4105MWK D-amino acid dehydrogenase, small subunit HUS01_10865 ENOG4105RQF LysR family Transcriptional regulator HUS01_10875 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) HUS01_10880 ENOG4105D01 (LipO)protein HUS01_10885 ENOG4108V06 Glutathione peroxidase HUS01_10895 ENOG4108QBX (LipO)protein HUS01_10900 ENOG4105CNG UPF0061 protein HUS01_10910 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HUS01_10925 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUS01_10935 ENOG4105IPI Membrane HUS01_10940 ENOG4105CQB FAD linked oxidase domain protein HUS01_10945 ENOG4105KA0 thioesterase Superfamily protein HUS01_10950 ENOG4105Y3U Transglycosylase-associated protein HUS01_10965 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HUS01_10975 ENOG4105E0A ABC, transporter HUS01_10980 ENOG4105EHG Permease protein HUS01_10990 ENOG4106KR7 LysR family Transcriptional regulator HUS01_11015 ENOG4105DMF Dehydrogenase HUS01_11020 ENOG4105KBX Transcriptional regulator, TetR family HUS01_11040 ENOG4108Z4V iron-sulfur cluster assembly HUS01_11045 ENOG4105DIW FeS assembly protein SUFB HUS01_11050 ENOG4105C3K feS assembly ATPase SufC HUS01_11055 ENOG4105JRK feS assembly protein SufD HUS01_11060 ENOG4105C9B Cysteine desulfurase HUS01_11065 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HUS01_11070 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HUS01_11080 ENOG4105CA9 Pyruvate kinase HUS01_11095 ENOG4105RFR Protein of unknown function (DUF2767) HUS01_11110 ENOG4105DJB Major Facilitator Superfamily HUS01_11115 ENOG4105E2X shikimate dehydrogenase HUS01_11120 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein HUS01_11125 ENOG4108W0P ABC transporter HUS01_11130 ENOG4105EHG Permease protein HUS01_11135 ENOG4105S10 periplasmic binding protein HUS01_11140 ENOG4108K2P TRANSCRIPTIONal HUS01_11145 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HUS01_11155 ENOG4107UB2 Alpha beta hydrolase fold HUS01_11160 ENOG4105IKQ hydratase HUS01_11170 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HUS01_11175 ENOG4108SC4 )-transporter HUS01_11190 ENOG4108T2C cysteine dioxygenase type I HUS01_11195 ENOG4105CR8 Transcriptional regulator HUS01_11200 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUS01_11220 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUS01_11225 ENOG4108IY8 ABC, transporter HUS01_11235 ENOG4105E0A ABC, transporter HUS01_11240 ENOG4105DQ5 transport system permease protein HUS01_11260 ENOG4106PMH Extracellular solute-binding protein family 3 HUS01_11265 ENOG4105E5Q amino acid AbC transporter HUS01_11270 ENOG4105CDA abc transporter atp-binding protein HUS01_11275 ENOG4105KZM cytoplasmic protein HUS01_11285 ENOG41083G8 Multidrug resistance protein MdtM HUS01_11310 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUS01_11315 ENOG4105DG4 malate L-lactate dehydrogenase HUS01_11320 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HUS01_11325 ENOG4107Z33 ABC transporter, permease HUS01_11355 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HUS01_11360 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HUS01_11365 ENOG41060IM Heme exporter protein HUS01_11375 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HUS01_11380 ENOG4105DA4 cytochrome c-type biogenesis protein HUS01_11385 ENOG4107QX9 Thiol disulfide interChange protein HUS01_11390 ENOG4105KWW Biogenesis protein HUS01_11395 ENOG4108M1T Cytochrome c-type biogenesis protein HUS01_11410 ENOG410822N TonB family HUS01_11445 ENOG4105BZS acriflavin resistance protein HUS01_11460 ENOG4105CHR reductase HUS01_11465 ENOG4105C7K acetolactate synthase HUS01_11480 ENOG4105DTD Dehydrogenase HUS01_11485 ENOG4105CY2 Citrate transporter HUS01_11490 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HUS01_11500 ENOG4107QNJ CoA-transferase subunit B HUS01_11510 ENOG4106NZI LysR family Transcriptional regulator HUS01_11535 ENOG4105CQB FAD linked oxidase domain protein HUS01_11540 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUS01_11560 ENOG4105KME endoribonuclease L-psp HUS01_11565 ENOG4107TTD cytosine deaminase HUS01_11575 ENOG4105EMY transcriptional regulator HUS01_11640 ENOG4108JQ7 (ABC) transporter HUS01_11645 ENOG4105C3U ABC transporter HUS01_11670 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HUS01_11675 ENOG4105E98 transcriptional regulator DeoR family HUS01_11685 ENOG4107B2H carbonic anhydrase HUS01_11710 ENOG4105CY0 Metallo-Beta-Lactamase HUS01_11745 ENOG4108URH decarboxylase HUS01_11755 ENOG4107QI1 Mate efflux family protein HUS01_11760 ENOG4108R6K riboflavin synthase, subunit alpha HUS01_11765 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUS01_11770 ENOG4105CZQ inner membrane transport protein YdhC HUS01_11775 ENOG4105F52 Transcriptional regulator HUS01_11780 ENOG4105ETE Transcriptional regulator (LacI family HUS01_11790 ENOG4105F27 Major Facilitator HUS01_11795 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HUS01_11805 ENOG4105K4H Nlp p60 protein HUS01_11810 ENOG4105M2J Glutaredoxin HUS01_11815 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HUS01_11820 ENOG4108UYE Lactoylglutathione lyase HUS01_11825 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUS01_11830 ENOG4108WUH Transcriptional regulator, TetR family HUS01_11835 ENOG4105XZD Fe-S protein HUS01_11840 ENOG4107RGM aldo keto reductase HUS01_11845 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HUS01_11850 ENOG4105DSW Fusaric acid resistance protein HUS01_11855 ENOG4105Y49 secretion protein, HlyD family HUS01_11870 ENOG4105BZU Histidine kinase HUS01_11875 ENOG4108XTF Outer Membrane Lipoprotein HUS01_11880 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HUS01_11885 ENOG410642K Lysozyme inhibitor HUS01_11890 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUS01_11895 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HUS01_11900 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HUS01_11905 ENOG4108K3A Glutathione S-transferase HUS01_11915 ENOG4105CSM endonuclease III HUS01_11925 ENOG4108UQQ Electron transport complex HUS01_11950 ENOG4105M9B inner membrane protein ydgK HUS01_11960 ENOG4105CS2 ec 3.2.1.21 HUS01_11970 ENOG4105D9R oxidoreductase HUS01_11975 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUS01_11980 ENOG4105EQ0 Major Facilitator superfamily HUS01_12000 ENOG4105CPW cytochrome b561 HUS01_12020 ENOG4105DDW LysR family Transcriptional regulator HUS01_12025 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HUS01_12030 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HUS01_12035 ENOG4105E32 cytoplasmic protein HUS01_12040 ENOG4105EBR Carboxylesterase HUS01_12055 ENOG4108Z9I -acetyltransferase HUS01_12060 ENOG4107WE3 acetyltransferase YdcK HUS01_12065 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HUS01_12070 ENOG41088CC tellurite resistance protein tehB HUS01_12075 ENOG4108KKZ (LipO)protein HUS01_12085 ENOG4105UEI Transcriptional Regulator AraC Family HUS01_12090 ENOG4105DKK Benzoate HUS01_12095 ENOG4108JCI Transcriptional regulator HUS01_12105 ENOG4105CFP Peptidase U32 HUS01_12125 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUS01_12130 ENOG4105C4M (Ubiquinol oxidase) subunit I HUS01_12135 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUS01_12140 ENOG4107TYH extracellular solute-binding protein family 1 HUS01_12145 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUS01_12150 ENOG4105D81 ABC transporter, permease HUS01_12155 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HUS01_12160 ENOG4105C26 Dehydrogenase HUS01_12185 ENOG410654E Membrane HUS01_12190 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUS01_12200 ENOG4105DEF Extracellular solute-binding protein, family 5 HUS01_12205 ENOG4105R71 cytoplasmic protein HUS01_12210 ENOG4108T9Y Inner membrane protein ydcZ HUS01_12215 ENOG4108Z7F N-acetyltransferase HUS01_12225 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUS01_12230 ENOG4105DU0 nucleoside hydrolase HUS01_12240 ENOG41065TG regulatoR HUS01_12245 ENOG4105CI2 imidazolone-5-propionate hydrolase HUS01_12250 ENOG4105CHB tonB-dependent Receptor HUS01_12255 ENOG4108NS2 receptor HUS01_12265 ENOG4105C85 amino acid HUS01_12280 ENOG4105DEN Luciferase family HUS01_12295 ENOG4105EAB amino acid AbC transporter HUS01_12305 ENOG4105DRP amino acid AbC transporter HUS01_12310 ENOG4105CDA abc transporter atp-binding protein HUS01_12320 ENOG4108N27 Glutathione S-transferase HUS01_12355 ENOG4108MEJ flavin reductase domain protein HUS01_12360 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUS01_12365 ENOG4105C4Y ABC transporter HUS01_12370 ENOG4107RCV ABC transporter, permease HUS01_12375 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HUS01_12380 ENOG4105D0D Nitrate reductase 2, gamma subunit HUS01_12385 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HUS01_12390 ENOG4108IUE nitrate reductase beta subunit HUS01_12395 ENOG4105CRU nitrate reductase, alpha subunit HUS01_12400 ENOG4107QND Nitrite extrusion protein HUS01_12415 ENOG4107HP6 Transcriptional regulator HUS01_12420 ENOG4105DTQ mandelate racemase muconate lactonizing HUS01_12425 ENOG4105NN7 muconolactone delta-isomerase HUS01_12430 ENOG410626B catechol 1,2-dioxygenase HUS01_12440 ENOG4108UKV benzoate 1,2-dioxygenase HUS01_12465 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HUS01_12470 ENOG4108MG3 formate dehydrogenase HUS01_12485 ENOG4105CSR polyphosphate kinase 2 HUS01_12495 ENOG4105F27 Major Facilitator HUS01_12510 ENOG4108JQ6 ABC transporter HUS01_12515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUS01_12530 ENOG4105DQ4 alcohol dehydrogenase HUS01_12545 ENOG4105C5H ABC transporter HUS01_12560 ENOG4107R1I NAD-dependent malic enzyme HUS01_12580 ENOG4105EQ2 LysR family Transcriptional regulator HUS01_12585 ENOG4105N0E Protein of unknown function (DUF2543) HUS01_12590 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUS01_12605 ENOG4108N8X transition metal ion binding HUS01_12615 ENOG4105CG3 alpha amylase, catalytic region HUS01_12635 ENOG4108YDI single-species biofilm formation on inanimate substrate HUS01_12645 ENOG4108Z9K Osmotically inducible protein HUS01_12670 ENOG4105FFC UPF0187 protein HUS01_12675 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HUS01_12680 ENOG4105C5Q Transcriptional regulator HUS01_12685 ENOG4105CK1 PTS System HUS01_12710 ENOG4105VZJ PTS System HUS01_12715 ENOG4105VCP PTS System HUS01_12720 ENOG4108KUU Inner membrane metabolite transport protein ydjE HUS01_12725 ENOG4105KT7 mgtC SapB transporter HUS01_12730 ENOG4105D6Z AFG1 family ATPase HUS01_12735 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HUS01_12740 ENOG4106KR7 LysR family Transcriptional regulator HUS01_12760 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUS01_12765 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF HUS01_12770 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HUS01_12780 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) HUS01_12785 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HUS01_12795 ENOG4108IGT Dipeptidase HUS01_12800 ENOG4108J2P Alpha beta hydrolase fold HUS01_12810 ENOG4105E0F Histidine kinase HUS01_12825 ENOG4105DY8 decarboxylase HUS01_12830 ENOG4108JPW Aminotransferase HUS01_12835 ENOG4107Z6I Thiamine biosynthesis protein HUS01_12840 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HUS01_12845 ENOG4108YI8 ABC transporter HUS01_12850 ENOG4105ETU transcriptional activator (TenA HUS01_12865 ENOG4105CIB oxidoreductase Domain protein HUS01_12875 ENOG4105ETE Transcriptional regulator (LacI family HUS01_12880 ENOG4105BZU Histidine kinase HUS01_12885 ENOG4107QUY Guanine deaminase HUS01_12890 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HUS01_12925 ENOG4105CVJ phosphoglycerate mutase HUS01_12930 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HUS01_12940 ENOG41089BK Glutamine amido-transferase HUS01_12960 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUS01_12985 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HUS01_13010 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HUS01_13030 ENOG4105E5Q amino acid AbC transporter HUS01_13040 ENOG4105C5R Aminotransferase HUS01_13055 ENOG4105CBN LysR family transcriptional regulator HUS01_13065 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUS01_13070 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HUS01_13075 ENOG4105CSH Transporter HUS01_13105 ENOG4105FCD Major Facilitator HUS01_13115 ENOG4105ETE Transcriptional regulator (LacI family HUS01_13120 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HUS01_13130 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HUS01_13135 ENOG4105UP7 3-epimerase HUS01_13145 ENOG4108YRF PTS System HUS01_13150 ENOG4105DM4 PTS System HUS01_13155 ENOG410829K Lysine exporter protein (Lyse ygga) HUS01_13165 ENOG4105CBN LysR family transcriptional regulator HUS01_13170 ENOG4105HEI LysR family (Transcriptional regulator HUS01_13185 ENOG4107PP3 Acetylornithine deacetylase HUS01_13200 ENOG4105CNN ABC, transporter HUS01_13205 ENOG4105C2J ABC transporter HUS01_13210 ENOG4105ETE Transcriptional regulator (LacI family HUS01_13240 ENOG4109066 lysm domain bon superfamily protein HUS01_13255 ENOG4105CNW domain protein HUS01_13265 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HUS01_13275 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta HUS01_13280 ENOG4105RHY Pfam:UPF0157 HUS01_13285 ENOG4105EQ2 LysR family Transcriptional regulator HUS01_13290 ENOG4105CPC Aldo Keto reductase HUS01_13295 ENOG4107SET aldo keto reductase HUS01_13305 ENOG4105CPC Aldo Keto reductase HUS01_13335 ENOG4105ENX hydrolase HUS01_13350 ENOG4105MVE transcriptional regulator HUS01_13355 ENOG4105CMG Carbohydrate kinase HUS01_13360 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HUS01_13365 ENOG4105E98 transcriptional regulator DeoR family HUS01_13370 ENOG4105UP7 3-epimerase HUS01_13375 ENOG4108RVA ribokinase HUS01_13380 ENOG4105EDR glucose galactose transporter HUS01_13395 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HUS01_13400 ENOG4105CHR reductase HUS01_13405 ENOG4105CHU acetyl-coa acetyltransferase HUS01_13425 ENOG4105BZW Glycerate kinase HUS01_13430 ENOG4107VHA regulatoR HUS01_13440 ENOG4105JQN Transcriptional regulator HUS01_13450 ENOG4107YCY Transcriptional regulator HUS01_13455 ENOG4105CI1 PTS System HUS01_13460 ENOG4105F8D glycoside hydrolase family 4 HUS01_13465 ENOG4105C54 Major Facilitator superfamily HUS01_13470 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HUS01_13485 ENOG4105NIV Esterase HUS01_13490 ENOG4105BZU Histidine kinase HUS01_13505 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HUS01_13520 ENOG4108VCD Chaperone HUS01_13525 ENOG4105CW0 outer membrane usher protein HUS01_13535 ENOG4105F32 YngK protein HUS01_13540 ENOG4105CAF HipA N-terminal domain protein HUS01_13545 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HUS01_13550 ENOG4105VT2 5-hydroxyisourate hydrolase HUS01_13555 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HUS01_13560 ENOG4105C2W permease HUS01_13565 ENOG41061H0 Monooxygenase HUS01_13570 ENOG4108KSA LysR family transcriptional regulator HUS01_13590 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HUS01_13605 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HUS01_13615 ENOG4105D01 (LipO)protein HUS01_13625 ENOG4108UMI ABC transporter, permease HUS01_13630 ENOG4105EA8 2-Nitropropane dioxygenase HUS01_13635 ENOG4105EGI Transcriptional regulator HUS01_13640 ENOG4105CBP Major Facilitator HUS01_13650 ENOG4105F9N Major Facilitator Superfamily HUS01_13700 ENOG4107QZW Altronate oxidoreductase HUS01_13710 ENOG4105BZU Histidine kinase HUS01_13715 ENOG4105M0C cytoplasmic protein HUS01_13720 ENOG4105CSV Glutaminase HUS01_13725 ENOG4105C26 Dehydrogenase HUS01_13730 ENOG4105EGI Transcriptional regulator HUS01_13740 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HUS01_13745 ENOG4105MVE transcriptional regulator HUS01_13750 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HUS01_13755 ENOG4107S2N Type III effector Hrp-dependent HUS01_13760 ENOG4105C0A alcohol dehydrogenase HUS01_13765 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUS01_13780 ENOG4108R66 Conserved Protein HUS01_13785 ENOG4105CHR reductase HUS01_13790 ENOG4105JAB phenazine biosynthesis protein, phzf family HUS01_13795 ENOG4105F27 Major Facilitator HUS01_13800 ENOG41082NP Multiple antibiotic resistance HUS01_13810 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HUS01_13815 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HUS01_13820 ENOG4106DNR multiple antibiotic resistance protein HUS01_13825 ENOG4108594 Permease of the drug metabolite transporter HUS01_13830 ENOG4105E5W Transporter HUS01_13840 ENOG4108IV0 ABC, transporter HUS01_13850 ENOG4105CNN ABC, transporter HUS01_13855 ENOG4105C32 Amino acid ABC transporter (Permease) HUS01_13860 ENOG41083Z3 extracellular ligand-binding receptor HUS01_13875 ENOG4105ECQ AraC Family Transcriptional Regulator HUS01_13890 ENOG4105ETE Transcriptional regulator (LacI family HUS01_13895 ENOG4105CNT hydrolase family 2 HUS01_13900 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HUS01_13905 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUS01_13915 ENOG4108J4B Beta-lactamase HUS01_13920 ENOG4105MVE transcriptional regulator HUS01_13930 ENOG4105G63 Type III effector Hrp-dependent HUS01_13935 ENOG4105FB2 class II Aldolase HUS01_13940 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HUS01_13945 ENOG4105C6Z Gluconate HUS01_13965 ENOG4105BZU Histidine kinase HUS01_13970 ENOG4108WTK competence damage-inducible protein HUS01_13975 ENOG4108ZNX Heat shock protein HUS01_13990 ENOG4108WQH regulatoR HUS01_14005 ENOG4108RAV Conserved protein HUS01_14010 ENOG4105R1U AraC Family Transcriptional Regulator HUS01_14020 ENOG4105DGW oligopeptidase A HUS01_14025 ENOG4105EMU Dehydrogenase HUS01_14030 ENOG4107XBN GntR Family Transcriptional Regulator HUS01_14035 ENOG4108U51 Universal stress protein HUS01_14040 ENOG4105DEI Mannitol dehydrogenase HUS01_14045 ENOG4108I5G Major Facilitator superfamily HUS01_14050 ENOG4105KK4 UPF0060 membrane protein HUS01_14055 ENOG4105M5Q UPF0482 protein HUS01_14060 ENOG4108MK9 spermidine N(1)-acetyltransferase HUS01_14070 ENOG4105KBG Protein of unknown function (DUF1161) HUS01_14075 ENOG4107QY8 reductase HUS01_14080 ENOG4105QAX Iron-sulfur HUS01_14085 ENOG4107KGK dmso reductase anchor subunit HUS01_14090 ENOG4108NEM leader-binding protein dmsD HUS01_14095 ENOG4105CMQ Chloride channel HUS01_14100 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HUS01_14105 ENOG4105DAG ROK family HUS01_14110 ENOG4106NZI LysR family Transcriptional regulator HUS01_14115 ENOG4105D94 Major Facilitator Superfamily HUS01_14120 ENOG4105CTD carboxy-peptidase HUS01_14130 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HUS01_14140 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) HUS01_14145 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HUS01_14150 ENOG4105DSF transport protein HUS01_14180 ENOG4107TT2 Auxin Efflux Carrier HUS01_14185 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HUS01_14190 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUS01_14195 ENOG4108K70 Transcriptional regulator HUS01_14200 ENOG4105DWT malate dehydrogenase (quinone) HUS01_14205 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HUS01_14215 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUS01_14220 ENOG4108MRH transcriptional regulatory protein HUS01_14240 ENOG4107GFK fumarate HUS01_14250 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HUS01_14255 ENOG4105F2Z 3-oxoadipate enol-lactonase HUS01_14260 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HUS01_14265 ENOG4105CHU acetyl-coa acetyltransferase HUS01_14270 ENOG4107QNJ CoA-transferase subunit B HUS01_14280 ENOG4107HP6 Transcriptional regulator HUS01_14285 ENOG4108DG9 Smr protein MutS2 HUS01_14290 ENOG4106KR7 LysR family Transcriptional regulator HUS01_14300 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HUS01_14305 ENOG4105CFC Transporter HUS01_14315 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUS01_14320 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HUS01_14325 ENOG4105Q9Y Universal stress protein HUS01_14330 ENOG410671Z uncharacterized protein ydiH HUS01_14335 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HUS01_14340 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HUS01_14350 ENOG4105C5D exported protein HUS01_14355 ENOG4105D5Q Arginine ornithine antiporter HUS01_14360 ENOG410642E Short chain dehydrogenase HUS01_14365 ENOG4105RA2 Membrane HUS01_14370 ENOG4107EXC regulatoR HUS01_14380 ENOG4105JJR Histidine kinase HUS01_14390 ENOG4105C9Q fumarate hydratase class II HUS01_14395 ENOG4107GFK fumarate HUS01_14400 ENOG4105EIP mannose-6-phosphate isomerase HUS01_14405 ENOG4106J39 exported protein HUS01_14410 ENOG4107P2S Transcriptional regulator HUS01_14415 ENOG4105CI1 PTS System HUS01_14420 ENOG4105C87 Aminotransferase class I and II HUS01_14430 ENOG41061EV selenium-binding protein YdfZ HUS01_14445 ENOG41066VF YeeE YedE family protein HUS01_14455 ENOG41064WM Uncharacterized protein YcgX HUS01_14460 ENOG4105VPI YqaE family transport protein HUS01_14465 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUS01_14470 ENOG4105C26 Dehydrogenase HUS01_14480 ENOG4107DB1 DUF218 domain HUS01_14485 ENOG4105CSH Transporter HUS01_14495 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HUS01_14500 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HUS01_14505 ENOG4105C26 Dehydrogenase HUS01_14510 ENOG4105F4X arginine HUS01_14515 ENOG4105C8Y Acetylornithine aminotransferase HUS01_14525 ENOG4105D82 Glutamate dehydrogenase HUS01_14530 ENOG4108FN7 Aldo keto reductase HUS01_14535 ENOG410642W LysR family Transcriptional regulator HUS01_14555 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HUS01_14565 ENOG4105CQ7 ATP-dependent helicase HUS01_14570 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUS01_14580 ENOG4108Z0R Transferase HUS01_14585 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HUS01_14590 ENOG4105DZS Phenylacetate-CoA ligase HUS01_14595 ENOG4105CHU acetyl-coa acetyltransferase HUS01_14600 ENOG4108ZJI phenylacetic acid degradation protein HUS01_14605 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUS01_14610 ENOG4108UKI Enoyl-CoA hydratase HUS01_14615 ENOG4105E39 Enoyl-CoA hydratase HUS01_14620 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUS01_14625 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HUS01_14630 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HUS01_14635 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HUS01_14640 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HUS01_14645 ENOG4105DXM phenylacetic acid degradation protein HUS01_14650 ENOG4105F11 amine oxidase HUS01_14665 ENOG4105C26 Dehydrogenase HUS01_14670 ENOG4108WFR AraC Family Transcriptional Regulator HUS01_14675 ENOG4105WXT Conserved Protein HUS01_14680 ENOG410689M (LipO)protein HUS01_14685 ENOG4107H52 Dicarboxylate transport HUS01_14690 ENOG4108KF1 Membrane HUS01_14695 ENOG4105C5I Dehydrogenase HUS01_14700 ENOG41090X5 Heat shock protein hslJ HUS01_14705 ENOG4105IKK cytoplasmic protein HUS01_14710 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HUS01_14715 ENOG4105FCK Membrane HUS01_14725 ENOG4108RW8 Universal stress protein F HUS01_14735 ENOG4105C1J atp-dependent rna helicase HUS01_14740 ENOG4107RX3 Mg2 transporter protein cora family protein HUS01_14745 ENOG4105E98 transcriptional regulator DeoR family HUS01_14750 ENOG4105D9R oxidoreductase HUS01_14765 ENOG4105C85 amino acid HUS01_14770 ENOG4105F7P transcriptional regulator AsnC family HUS01_14780 ENOG4105CGF Aromatic amino acid aminotransferase HUS01_14785 ENOG4108UMI ABC transporter, permease HUS01_14795 ENOG4105D01 (LipO)protein HUS01_14835 ENOG4105HEI LysR family (Transcriptional regulator HUS01_14860 ENOG4108XFH Transcriptional regulator HUS01_14865 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HUS01_14955 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUS01_14965 ENOG4108ZG0 Ompa motb domain protein HUS01_14990 ENOG4106FE3 DNA repair HUS01_15080 ENOG4105E4C Lytic transglycosylase catalytic HUS01_15150 ENOG4107ZQ5 Phage-associated protein, HI1409 family HUS01_15155 ENOG4108N0N Phage Terminase Large Subunit HUS01_15185 ENOG4105HGD Antitermination protein HUS01_15290 ENOG4105DFP Integrase HUS01_15295 ENOG4108Z0Z intracellular protease Pfpi family HUS01_15310 ENOG4105CBN LysR family transcriptional regulator HUS01_15335 ENOG4107RTG Major Facilitator superfamily HUS01_15340 ENOG4105ENX hydrolase HUS01_15345 ENOG4105EQ2 LysR family Transcriptional regulator HUS01_15360 ENOG4107QSI ABC, transporter HUS01_15370 ENOG4105KXI murein peptide amidase A HUS01_15375 ENOG4107S8C mandelate racemase muconate lactonizing HUS01_15380 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HUS01_15385 ENOG4108KK1 membrane protein AbrB duplication HUS01_15390 ENOG4108JU8 Transcriptional regulator HUS01_15395 ENOG4105F8D glycoside hydrolase family 4 HUS01_15400 ENOG4105W8I Transcriptional regulator HUS01_15405 ENOG4106K28 UPF0283 membrane protein HUS01_15410 ENOG4105CM6 amino acid regulated cytosolic protein HUS01_15415 ENOG4105NNG Peripheral inner membrane phage-shock protein HUS01_15420 ENOG4105FM1 phage shock protein C HUS01_15425 ENOG4105YYT phage shock protein B HUS01_15430 ENOG41087YS Phage shock protein A HUS01_15435 ENOG4105E51 psp operon transcriptional activator HUS01_15445 ENOG4105CH2 amidohydrolase HUS01_15450 ENOG41063ZK Transcriptional Regulator AraC Family HUS01_15465 ENOG4108J59 Extracellular solute-binding protein, family 5 HUS01_15470 ENOG4108EKA peptide transport system, permease HUS01_15475 ENOG4108RAV Conserved protein HUS01_15485 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUS01_15490 ENOG4105KT5 UmuD protein HUS01_15495 ENOG4105EKQ RNA-directed DNA polymerase HUS01_15505 ENOG4108BUD transposase HUS01_15550 ENOG4108R1E Serine threonine protein phosphatase 1 HUS01_15555 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HUS01_15665 ENOG4108EU3 peptide transport system, permease HUS01_15670 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HUS01_15675 ENOG4108JQ2 peptide transport system atp-binding protein HUS01_15680 ENOG4105ETS cytosine purines uracil thiamine allantoin HUS01_15690 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HUS01_15695 ENOG4105Q4T oxidoreductase HUS01_15700 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HUS01_15710 ENOG4105N2W Transcriptional regulator HUS01_15715 ENOG41061RM osmotically inducible lipoprotein HUS01_15720 ENOG4108ZJT translation initiation factor, Sui1 HUS01_15730 ENOG4105CFV Tetratricopeptide repeat protein HUS01_15735 ENOG4105Q4A inner membrane protein yciS HUS01_15740 ENOG4105EYK Phosphatidylglycerophosphatase B HUS01_15745 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HUS01_15750 ENOG4107QM5 aconitate hydratase HUS01_15760 ENOG4107R11 Transcriptional regulator HUS01_15765 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUS01_15770 ENOG4105RKX Protein of unknown function (DUF2498) HUS01_15775 ENOG4105ERU peptidase HUS01_15785 ENOG4105UBK short-chain dehydrogenase reductase HUS01_15790 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HUS01_15800 ENOG4105ETT transcriptional Regulator, LysR family HUS01_15810 ENOG4107RTD sua5 ycio yrdc ywlc family protein HUS01_15815 ENOG4105DB7 PHP domain protein HUS01_15820 ENOG4105CRQ synthase (Component I) HUS01_15825 ENOG4108EFP Anthranilate synthase component II HUS01_15830 ENOG4105DK0 Indole-3-glycerol phosphate synthase HUS01_15835 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUS01_15840 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUS01_15885 ENOG4108IU3 tonb-dependent siderophore receptor HUS01_15890 ENOG4107E2E PKHD-type hydroxylase HUS01_15895 ENOG4105EIF outer membrane protein W HUS01_15900 ENOG4105PI0 Ferredoxin HUS01_15905 ENOG4108S3I UPF0259 membrane protein HUS01_15910 ENOG4107835 probably involved in intracellular septation (By similarity) HUS01_15915 ENOG4107RNH Outer membrane receptor FepA HUS01_15920 ENOG4105NAU thioesterase Superfamily protein HUS01_15925 ENOG4107PN8 YfeABCD locus regulator HUS01_15930 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HUS01_15935 ENOG4105CHR reductase HUS01_15940 ENOG4107K5X Membrane-bound metal-dependent hydrolase HUS01_15945 ENOG4108ETY sodium dicarboxylate symporter HUS01_15950 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HUS01_15955 ENOG4105CH6 catalase HUS01_15960 ENOG410901P UPF0249 protein HUS01_15965 ENOG4105F8D glycoside hydrolase family 4 HUS01_15970 ENOG4105EZV Transcriptional regulator HUS01_15975 ENOG4105VCP PTS System HUS01_15980 ENOG4105CK1 PTS System HUS01_15990 ENOG4105VZJ PTS System HUS01_15995 ENOG4105KKI DNA-binding transcriptional activator OsmE HUS01_16005 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HUS01_16010 ENOG4108SPG Periplasmic Protein HUS01_16020 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HUS01_16025 ENOG4105C26 Dehydrogenase HUS01_16030 ENOG4105F4X arginine HUS01_16040 ENOG4105CGK Exodeoxyribonuclease III HUS01_16045 ENOG4108RSN SNARE associated Golgi HUS01_16050 ENOG4108N5C SNARE associated Golgi protein-related protein HUS01_16055 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUS01_16060 ENOG4105VNH ABC transporter solute-binding protein HUS01_16065 ENOG4105CXZ ABC transporter, permease HUS01_16070 ENOG4108VGW abc transporter atp-binding protein HUS01_16075 ENOG4107RM6 sulfurtransferase HUS01_16080 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HUS01_16085 ENOG4105M6F mutator MutT protein HUS01_16090 ENOG4105D82 Glutamate dehydrogenase HUS01_16100 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUS01_16105 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HUS01_16110 ENOG4105SBG acid phosphatase HUS01_16120 ENOG41069NU Nitroreductase HUS01_16125 ENOG4105D07 Signal peptide peptidase, SppA HUS01_16130 ENOG4105HDK L-asparaginase HUS01_16135 ENOG4108RWI nicotinamidase HUS01_16140 ENOG4108KUU Inner membrane metabolite transport protein ydjE HUS01_16145 ENOG4105E98 transcriptional regulator DeoR family HUS01_16150 ENOG4105CPC Aldo Keto reductase HUS01_16155 ENOG4107UH8 sugar kinase HUS01_16160 ENOG4105D2N Aldolase HUS01_16165 ENOG4105CPQ Dehydrogenase HUS01_16175 ENOG4105CPQ Dehydrogenase HUS01_16185 ENOG4105N1F Hnh endonuclease HUS01_16190 ENOG4105VUT cytoplasmic protein HUS01_16195 ENOG4105E0X reductase HUS01_16200 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUS01_16205 ENOG4105DSB aldose 1-epimerase HUS01_16215 ENOG4105GNX MltA-interacting MipA family protein HUS01_16220 ENOG4105CYN Serine protein kinase HUS01_16225 ENOG4106AKX UPF0229 protein HUS01_16235 ENOG4108V06 Glutathione peroxidase HUS01_16260 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HUS01_16265 ENOG4105CBN LysR family transcriptional regulator HUS01_16270 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUS01_16275 ENOG4105KT5 UmuD protein HUS01_16280 ENOG4105EKQ RNA-directed DNA polymerase HUS01_16285 ENOG4105Y50 Virulence Protein HUS01_16290 ENOG4108XNZ glycosyl transferase HUS01_16295 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HUS01_16300 ENOG4108VMM UPF0756 membrane protein HUS01_16305 ENOG4105R1U AraC Family Transcriptional Regulator HUS01_16310 ENOG4105DJ2 Major Facilitator Superfamily HUS01_16315 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUS01_16320 ENOG4105EWC Purine nucleoside phosphorylase HUS01_16325 ENOG4105K78 MarR family Transcriptional regulator HUS01_16330 ENOG4105UCG Domain of unknown function (DUF333) HUS01_16335 ENOG410620I Diguanylate cyclase HUS01_16340 ENOG4106G4W HUS01_16355 ENOG4105S5I Membrane HUS01_16360 ENOG4108NIW Leucine export protein LeuE HUS01_16365 ENOG4105D1S lipid A biosynthesis HUS01_16375 ENOG4105DHT Metal Dependent Phosphohydrolase HUS01_16380 ENOG4106TD9 Diguanylate cyclase HUS01_16385 ENOG4107RSM transcriptional regulator HUS01_16390 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HUS01_16420 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUS01_16425 ENOG4105C4M (Ubiquinol oxidase) subunit I HUS01_16430 ENOG4105WEF catalase HUS01_16435 ENOG4108N8X transition metal ion binding HUS01_16440 ENOG4108Z9Z response to DNA damage stimulus HUS01_16450 ENOG4105E2A Dehydrogenase HUS01_16455 ENOG4105XDF Protein of unknown function (DUF1272) HUS01_16475 ENOG4108ZHR arsR family transcriptional regulator HUS01_16480 ENOG4108HMX isocitrate dehydrogenase (NADP) HUS01_16565 ENOG4105D07 Signal peptide peptidase, SppA HUS01_16580 ENOG4105CAR Terminase, large subunit HUS01_16625 ENOG4105KUS lysozyme HUS01_16630 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HUS01_16650 ENOG4108MXB Protein of unknown function (DUF968) HUS01_16670 ENOG4105EKQ RNA-directed DNA polymerase HUS01_16675 ENOG4105Y50 Virulence Protein HUS01_16760 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUS01_16835 ENOG4108MXB Protein of unknown function (DUF968) HUS01_16840 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HUS01_16875 ENOG4105DH7 May be involved in recombination (By similarity) HUS01_16925 ENOG4108I1J Integrase HUS01_16930 ENOG4108HMX isocitrate dehydrogenase (NADP) HUS01_16945 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HUS01_16950 ENOG41075W9 High frequency lysogenization protein HflD homolog HUS01_16955 ENOG4107QTF adenylosuccinate lyase HUS01_16975 ENOG4105IFJ Histidine kinase HUS01_16980 ENOG4105EZE Cupin 4 family protein HUS01_17000 ENOG4105D38 putrescine abc transporter HUS01_17005 ENOG4108HM4 ABC transporter HUS01_17015 ENOG4105CEY Amp-dependent synthetase and ligase HUS01_17025 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HUS01_17030 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HUS01_17035 ENOG4105D60 lipoprotein releasing system transmembrane protein HUS01_17040 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUS01_17045 ENOG4105D60 lipoprotein releasing system transmembrane protein HUS01_17055 ENOG4108JA2 transcriptioN-repair coupling factor HUS01_17060 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HUS01_17065 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HUS01_17075 ENOG4108IND Tetr family transcriptional regulator HUS01_17090 ENOG4107MBR 17 kDa surface antigen HUS01_17095 ENOG4105CEP NADH dehydrogenase HUS01_17100 ENOG4105D0Y UPF0227 protein HUS01_17115 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HUS01_17120 ENOG41090DQ Lipoprotein HUS01_17125 ENOG4105K59 histidine triad (HIT) protein HUS01_17130 ENOG4105CI1 PTS System HUS01_17135 ENOG4105F8V Hydrolase, tatD family HUS01_17140 ENOG4107QRG dna polymerase iii HUS01_17145 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUS01_17150 ENOG4105HHA aminodeoxychorismate lyase HUS01_17155 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HUS01_17160 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUS01_17165 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUS01_17170 ENOG4105CHR reductase HUS01_17175 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUS01_17180 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUS01_17185 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HUS01_17190 ENOG4105VGS 50s ribosomal protein l32 HUS01_17195 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HUS01_17200 ENOG4108UHJ MAF-like protein HUS01_17205 ENOG4105EI2 Pseudouridine synthase HUS01_17215 ENOG4107QQB Ribonuclease E HUS01_17220 ENOG4105CR8 Transcriptional regulator HUS01_17225 ENOG4105EQ0 Major Facilitator superfamily HUS01_17230 ENOG4105CJR Integral membrane protein (MviN HUS01_17235 ENOG4105EP9 oxidoreductase HUS01_17240 ENOG4108YXG UPF0502 protein HUS01_17245 ENOG4105D9U N-acetyltransferase HUS01_17250 ENOG4105EV4 Multidrug resistance protein mdtH HUS01_17255 ENOG4105F3T (LipO)protein HUS01_17260 ENOG4105EKE dihydroorotase HUS01_17265 ENOG4105MEA DNA damage-inducible protein i HUS01_17270 ENOG4105PVA Biofilm formation regulatory protein BssS HUS01_17280 ENOG4106974 biofilm formation HUS01_17290 ENOG4105D1S lipid A biosynthesis HUS01_17300 ENOG4108W47 Acidic protein msyB HUS01_17305 ENOG4105NAC (LipO)protein HUS01_17310 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HUS01_17320 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HUS01_17335 ENOG4108UQ5 membrane protein YcdZ HUS01_17340 ENOG4107XHZ cytoplasmic chaperone TorD family protein HUS01_17350 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HUS01_17370 ENOG4105HEI LysR family (Transcriptional regulator HUS01_17375 ENOG4105EUB pirin domain protein HUS01_17380 ENOG4105CHJ isochorismatase hydrolase HUS01_17390 ENOG4108Z33 Thiol disulfide Interchange Protein HUS01_17395 ENOG4105D5M phosphate starvation-inducible protein HUS01_17400 ENOG4105DBE peroxidase HUS01_17405 ENOG410650H (LipO)protein HUS01_17415 ENOG4105D9N nucleoside HUS01_17425 ENOG4105CK7 Sodium proline symporter HUS01_17430 ENOG4105C26 Dehydrogenase HUS01_17440 ENOG4108R86 Transcriptional regulator HUS01_17445 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HUS01_17450 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HUS01_17455 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) HUS01_17460 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUS01_17465 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HUS01_17470 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HUS01_17475 ENOG4105C2W permease HUS01_17485 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HUS01_17500 ENOG4105XH3 HUS01_17505 ENOG4105D6F Phosphatase HUS01_17515 ENOG4105CHR reductase HUS01_17530 ENOG4105CUB amino acid HUS01_17535 ENOG4105CFQ glutamine synthetase HUS01_17540 ENOG4108Z86 Glutamine amidotransferase HUS01_17545 ENOG4107VRI Transcriptional regulator HUS01_17550 ENOG4105C26 Dehydrogenase HUS01_17555 ENOG4105CJP fad dependent oxidoreductase HUS01_17560 ENOG4105EJC lysr family transcriptional regulator HUS01_17565 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUS01_17570 ENOG4105C94 Transporter HUS01_17575 ENOG4105DVW rieske (2Fe-2S) HUS01_17580 ENOG4105C26 Dehydrogenase HUS01_17585 ENOG4105E3J oxidoreductase HUS01_17605 ENOG4107QSI ABC, transporter HUS01_17610 ENOG4108MN8 Membrane HUS01_17620 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HUS01_17625 ENOG4108UQN AraC family transcriptional regulator HUS01_17630 ENOG4108V1U phospholipid-binding protein HUS01_17635 ENOG4105DR4 Methyltransferase HUS01_17640 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HUS01_17645 ENOG4105K4P CoA-binding domain protein HUS01_17655 ENOG41088T4 Helicase IV HUS01_17660 ENOG410901E Membrane HUS01_17665 ENOG4105EM2 membrane HUS01_17670 ENOG4108RZ1 DNA transformation protein HUS01_17675 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) HUS01_17680 ENOG4105UYK outer membrane protein a HUS01_17685 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HUS01_17690 ENOG4105DAN ATP-dependent protease HUS01_17695 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) HUS01_17700 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HUS01_17705 ENOG4108Q2G (LipO)protein HUS01_17710 ENOG4105DY2 Paraquat-inducible protein b HUS01_17715 ENOG4105F1S paraquat-inducible protein a HUS01_17720 ENOG4105C5H ABC transporter HUS01_17725 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HUS01_17730 ENOG4105QVC MOSC domain-containing protein HUS01_17735 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HUS01_17745 ENOG4108UZX fmn reductase HUS01_17750 ENOG4105GVF (ABC) transporter HUS01_17755 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUS01_17760 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUS01_17770 ENOG4105CD8 aminopeptidase N HUS01_17775 ENOG4107RH7 Nicotinate phosphoribosyltransferase HUS01_17780 ENOG4105CH2 amidohydrolase HUS01_17785 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HUS01_17790 ENOG4105C44 Serine transporter HUS01_17795 ENOG4107RCH Diaminopropionate ammonia-lyase HUS01_17805 ENOG4105C5S asparaginyl-tRNA synthetase HUS01_17815 ENOG4105CGF Aromatic amino acid aminotransferase HUS01_17820 ENOG4105C5X domain protein HUS01_17825 ENOG4105EAQ (twin-arginine translocation) pathway signal HUS01_17830 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HUS01_17835 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HUS01_17840 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HUS01_17845 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HUS01_17850 ENOG4106371 Methyltransferase HUS01_17855 ENOG4107S90 membrAne HUS01_17860 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HUS01_17865 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HUS01_17870 ENOG4105W49 UPF0434 protein HUS01_17875 ENOG4105T0Z Conserved Protein HUS01_17880 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HUS01_17885 ENOG4105BZ1 (ABC) transporter HUS01_17890 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HUS01_17895 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HUS01_17900 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HUS01_17905 ENOG4105CAT Cytidine monophosphate kinase HUS01_17910 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUS01_17915 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HUS01_17920 ENOG4107VMU Membrane HUS01_17925 ENOG4105DDY UPF0142 protein ycaO HUS01_17930 ENOG4105TMB Formate nitrite transporter HUS01_17935 ENOG4105C6N Formate acetyltransferase HUS01_17940 ENOG4105F1A Pyruvate formate-lyase HUS01_17945 ENOG4108ISG Major Facilitator HUS01_17950 ENOG4107KGK dmso reductase anchor subunit HUS01_17955 ENOG4105QAX Iron-sulfur HUS01_17960 ENOG4107QY8 reductase HUS01_17965 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUS01_17970 ENOG4105D1H recombination factor protein RarA HUS01_17975 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HUS01_17980 ENOG4105CNU cell division protein FtsK HUS01_17985 ENOG4105EW9 transcriptional regulator AsnC family HUS01_17990 ENOG4105C3M thioredoxin reductase HUS01_17995 ENOG4108JJ9 ABC, transporter HUS01_18000 ENOG4108JJ8 (ABC) transporter HUS01_18005 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HUS01_18010 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HUS01_18015 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUS01_18020 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HUS01_18025 ENOG4105VEQ Cold shock protein HUS01_18035 ENOG4105DJY efflux transporter, rnd family, mfp subunit HUS01_18040 ENOG4105CPB ATP-dependent endonuclease of the OLD family HUS01_18045 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUS01_18050 ENOG4105DWU Membrane HUS01_18060 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUS01_18070 ENOG4105C7K acetolactate synthase HUS01_18075 ENOG4105C5W Aldolase HUS01_18080 ENOG4105CGD Nad-dependent epimerase dehydratase HUS01_18085 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HUS01_18090 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HUS01_18100 ENOG41064MM (LipO)protein HUS01_18105 ENOG4105E5Z arginine transporter ATP-binding subunit HUS01_18110 ENOG4106PMH Extracellular solute-binding protein family 3 HUS01_18115 ENOG4105GBT ABC transporter HUS01_18120 ENOG4105DMR ABC, transporter HUS01_18125 ENOG4106TNF Periplasmic binding protein HUS01_18130 ENOG4105BZU Histidine kinase HUS01_18135 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUS01_18140 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HUS01_18145 ENOG4105RBQ inner membrane protein ybjO HUS01_18150 ENOG4105D38 putrescine abc transporter HUS01_18155 ENOG4105F38 ABC transporter, permease HUS01_18160 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUS01_18165 ENOG4107RUE extracellular solute-binding protein family 1 HUS01_18170 ENOG4108RMJ sensory transduction regulator HUS01_18185 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HUS01_18190 ENOG41090BQ Glutaredoxin HUS01_18195 ENOG4105GWF inner membrane protein YbjM HUS01_18200 ENOG4105D0C transport protein HUS01_18205 ENOG4105ZTC transcriptional activator, Ogr delta HUS01_18365 ENOG4105ED4 portal protein HUS01_18390 ENOG4105VZ1 Replication Protein HUS01_18395 ENOG4105DFE Dna adenine methylase HUS01_18400 ENOG4105KSC Transcriptional regulator, TraR DksA family HUS01_18425 ENOG4105MEH HUS01_18440 ENOG4105EKQ RNA-directed DNA polymerase HUS01_18445 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUS01_18450 ENOG4108RFG Tetr family transcriptional regulator HUS01_18455 ENOG4106UW1 Major Facilitator superfamily HUS01_18460 ENOG4108HCJ Hydrolase HUS01_18465 ENOG4107QF7 multi-drug HUS01_18470 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HUS01_18475 ENOG4107FB0 transcriptional regulator DeoR family HUS01_18480 ENOG4105DZ1 carboxypeptidase HUS01_18490 ENOG4108TGY Glutathione S-transferase HUS01_18495 ENOG4105D8V Glucose sorbosone dehydrogenase HUS01_18500 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HUS01_18505 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HUS01_18510 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HUS01_18515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUS01_18520 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUS01_18525 ENOG4105DEF Extracellular solute-binding protein, family 5 HUS01_18530 ENOG4108JQ6 ABC transporter HUS01_18535 ENOG4105D44 asparaginase HUS01_18540 ENOG4105CVM Molybdenum cofactor synthesis domain protein HUS01_18545 ENOG4105D06 uba thif-type nad fad binding protein HUS01_18550 ENOG4105F1A Pyruvate formate-lyase HUS01_18560 ENOG4108HCJ Hydrolase HUS01_18565 ENOG41072TH Protein of unknown function (DUF1479) HUS01_18570 ENOG4105ETE Transcriptional regulator (LacI family HUS01_18575 ENOG4105DPW Major facilitator superfamily MFS_1 HUS01_18585 ENOG4105C5H ABC transporter HUS01_18590 ENOG4105M2Z protein tyrosine serine phosphatase HUS01_18595 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HUS01_18600 ENOG4108TZY GntR Family Transcriptional Regulator HUS01_18605 ENOG4105CS2 ec 3.2.1.21 HUS01_18610 ENOG4105F4P )-transporter HUS01_18615 ENOG4105KST dependent repressor HUS01_18625 ENOG4108I6E Sulfatase HUS01_18630 ENOG4108T1M outer membrane protein x HUS01_18640 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HUS01_18645 ENOG4107R0W ABC transporter HUS01_18650 ENOG4105E5Q amino acid AbC transporter HUS01_18655 ENOG4105CDA abc transporter atp-binding protein HUS01_18660 ENOG4105D8X mechanosensitive ion channel HUS01_18665 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HUS01_18670 ENOG4105EW6 flavin reductase domain protein, FMN-binding HUS01_18680 ENOG4105KSC Transcriptional regulator, TraR DksA family HUS01_18685 ENOG4105VR4 UPF0379 protein ybiJ HUS01_18690 ENOG4108MTB glycosyl transferase family HUS01_18695 ENOG4105DVT helicase HUS01_18700 ENOG4105C1J atp-dependent rna helicase HUS01_18720 ENOG4105DJB Major Facilitator Superfamily HUS01_18730 ENOG4108PZW LysR family Transcriptional regulator HUS01_18735 ENOG4107MVR Transcriptional regulator HUS01_18740 ENOG4105D0S secretion protein (HlyD HUS01_18745 ENOG4105CJ1 ABC, transporter HUS01_18750 ENOG4107QWP ABC-2 type transporter HUS01_18755 ENOG4107QWP ABC-2 type transporter HUS01_18760 ENOG4105I9U inner membrane protein ybhQ HUS01_18765 ENOG4105X23 Endonuclease Exonuclease phosphatase HUS01_18770 ENOG4105DZQ phospholipase D Transphosphatidylase HUS01_18775 ENOG4107UXM Membrane HUS01_18780 ENOG4105HFZ Membrane HUS01_18785 ENOG4108ZAF Molybdopterin HUS01_18790 ENOG4105M00 molybdopterin converting factor, subunit 1 HUS01_18795 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUS01_18800 ENOG4108RIR Molybdenum cofactor biosynthesis protein HUS01_18805 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUS01_18810 ENOG4105CHW UPF0052 protein HUS01_18815 ENOG4105DIJ Phosphoethanolamine transferase HUS01_18820 ENOG4105XJC Two component transcriptional regulator (Winged helix family HUS01_18825 ENOG4105ECM Sensor protein basS pmrB HUS01_18830 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HUS01_18840 ENOG4108IV0 ABC, transporter HUS01_18850 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUS01_18855 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUS01_18860 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HUS01_18865 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUS01_18870 ENOG4108V1U phospholipid-binding protein HUS01_18875 ENOG4105C85 amino acid HUS01_18880 ENOG4105C84 Histidine ammonia-lyase HUS01_18885 ENOG4105CGP Urocanate hydratase HUS01_18900 ENOG41088SP formiminoglutamate hydrolase HUS01_18905 ENOG4105CI2 imidazolone-5-propionate hydrolase HUS01_18910 ENOG4105NBR Pectinesterase HUS01_18945 ENOG4108XDN Transcriptional regulator HUS01_18950 ENOG4105BZU Histidine kinase HUS01_18955 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HUS01_18970 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HUS01_18975 ENOG4108K4B hydrolase HUS01_18980 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HUS01_18985 ENOG4105E0C molybdate abc transporter HUS01_18990 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HUS01_19000 ENOG4105F4R Transcriptional regulator mode HUS01_19005 ENOG4105DKW ABC transporter HUS01_19010 ENOG4105CMR udp-glucose 4-epimerase HUS01_19015 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HUS01_19020 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HUS01_19025 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HUS01_19030 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUS01_19035 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HUS01_19040 ENOG4105JND homeobox protein HUS01_19045 ENOG4105PGM cation diffusion facilitator family transporter HUS01_19050 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HUS01_19055 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HUS01_19095 ENOG4105UFD tol-pal system protein YbgF HUS01_19100 ENOG4105KCK Peptidoglycan-associated lipoprotein HUS01_19110 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HUS01_19120 ENOG4105E02 MotA TolQ exbB proton channel HUS01_19125 ENOG4107YD3 Thioesterase HUS01_19130 ENOG4105KJB cyd operon protein YbgE HUS01_19140 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUS01_19145 ENOG4105C4M (Ubiquinol oxidase) subunit I HUS01_19150 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HUS01_19155 ENOG4105CMV Succinyl-CoA synthetase subunit beta HUS01_19160 ENOG4105C7S Dehydrogenase HUS01_19165 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HUS01_19170 ENOG4105E33 succinate dehydrogenase HUS01_19175 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HUS01_19180 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HUS01_19185 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HUS01_19190 ENOG4105BZN citrate synthase HUS01_19195 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HUS01_19215 ENOG4105E7W lamb ycsf family protein HUS01_19220 ENOG4107R7A Allophanate hydrolase subunit 2 HUS01_19225 ENOG4105P4J Allophanate hydrolase, subunit 1 HUS01_19230 ENOG4107QNR UPF0135 protein HUS01_19235 ENOG4105DUX Transporter HUS01_19240 ENOG4105CVP deoxyribo-dipyrimidine photolyase HUS01_19245 ENOG4105XIQ Protein of unknown function (DUF2517) HUS01_19255 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUS01_19260 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUS01_19265 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HUS01_19270 ENOG4105C08 Histidine kinase HUS01_19275 ENOG4105EEX Two component transcriptional regulator (Winged helix family HUS01_19285 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HUS01_19290 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HUS01_19295 ENOG4105EV9 Alpha Beta Hydrolase HUS01_19300 ENOG4105NNH LexA regulated protein HUS01_19305 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HUS01_19310 ENOG41090R7 Ferric uptake HUS01_19320 ENOG4105GX6 (LipO)protein HUS01_19325 ENOG4105J5J Outer membrane porin HUS01_19335 ENOG4105CX6 glutaminyL-tRNA synthetase HUS01_19340 ENOG4105CI1 PTS System HUS01_19345 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HUS01_19350 ENOG4105CE4 GlcNAc 6-P deacetylase HUS01_19355 ENOG4105E2R ROK family HUS01_19360 ENOG4105D4U had-superfamily hydrolase, subfamily iia HUS01_19365 ENOG4105CAQ asparagine synthetase HUS01_19405 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HUS01_19410 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUS01_19415 ENOG4105C9A Phoh family HUS01_19420 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HUS01_19425 ENOG4108JU5 Magnesium and cobalt efflux protein HUS01_19430 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HUS01_19435 ENOG4107RP9 extracellular solute-binding protein, family 3 HUS01_19440 ENOG4105EAD ABC transporter HUS01_19445 ENOG4105DRP amino acid AbC transporter HUS01_19450 ENOG4105CDA abc transporter atp-binding protein HUS01_19465 ENOG4107PAI alpha helical protein HUS01_19470 ENOG4105C8T Leucyl-tRNA synthetase HUS01_19480 ENOG4105DJF DNA polymerase III, delta' subunit HUS01_19485 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HUS01_19490 ENOG4108TGR phosphatase HUS01_19495 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HUS01_19500 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HUS01_19505 ENOG4105CJN penicillin-binding protein HUS01_19510 ENOG4105CNI cell division protein FtsW HUS01_19515 ENOG4105K6T rare lipoprotein A HUS01_19520 ENOG4105DZ1 carboxypeptidase HUS01_19525 ENOG4108Z43 UPF0250 protein HUS01_19530 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUS01_19535 ENOG41064T2 transcriptional regulator, lysR family HUS01_19540 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HUS01_19545 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HUS01_19565 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HUS01_19570 ENOG4105CEE C4-dicarboxylate transporter HUS01_19575 ENOG4105KTS ribonuclease HUS01_19580 ENOG4105NXH GreA GreB family elongation factor HUS01_19585 ENOG4108U51 Universal stress protein HUS01_19590 ENOG4108JU3 Alkyl hydroperoxide reductase HUS01_19595 ENOG4105D3R alkyl hydroperoxide reductase HUS01_19600 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HUS01_19605 ENOG4105DQS Transcriptional regulator HUS01_19610 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HUS01_19615 ENOG4105GTN ParB Domain Protein Nuclease HUS01_19620 ENOG4105CHM Aminotransferase HUS01_19625 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HUS01_19630 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HUS01_19645 ENOG4105C2J ABC transporter HUS01_19655 ENOG4105CNN ABC, transporter HUS01_19665 ENOG4108M3J Dehydrogenase HUS01_19675 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HUS01_19680 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HUS01_19690 ENOG4105DZC cytosine deaminase HUS01_19700 ENOG4105ECY inositol monophosphatase HUS01_19705 ENOG4105CXY transporter HUS01_19710 ENOG4105D6F Phosphatase HUS01_19715 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HUS01_19720 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HUS01_19735 ENOG4105CNN ABC, transporter HUS01_19740 ENOG4105C2J ABC transporter HUS01_19745 ENOG4107SCQ Iron-containing alcohol dehydrogenase HUS01_19750 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HUS01_19765 ENOG4105VCD cytoplasmic protein HUS01_19770 ENOG4105D22 carbon starvation protein HUS01_19775 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HUS01_19780 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HUS01_19785 ENOG4105WQI isochorismatase HUS01_19790 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUS01_19795 ENOG4105E4F Isochorismate synthase HUS01_19800 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HUS01_19805 ENOG4105E8G Major facilitator Superfamily HUS01_19810 ENOG4105DQ5 transport system permease protein HUS01_19815 ENOG4105TVJ transport system, permease HUS01_19820 ENOG4105E0A ABC, transporter HUS01_19825 ENOG4105C0W non-ribosomal peptide synthetase HUS01_19830 ENOG41085A6 mbth domain-containing protein HUS01_19835 ENOG4105E93 esterase HUS01_19840 ENOG4107RNH Outer membrane receptor FepA HUS01_19845 ENOG4108TSE Transferase HUS01_19850 ENOG4108IUS Transketolase HUS01_19855 ENOG4108HHA Transketolase HUS01_19860 ENOG4105DKT Transcriptional regulator HUS01_19865 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUS01_19870 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUS01_19880 ENOG4105C2J ABC transporter HUS01_19885 ENOG4105CNN ABC, transporter HUS01_19895 ENOG4108R85 Short chain dehydrogenase HUS01_19905 ENOG410810E transcriptional regulator, lysR family HUS01_19910 ENOG4105CUY Mechanosensitive ion channel HUS01_19915 ENOG4108WN0 inhibitor of vertebrate lysozyme HUS01_19920 ENOG4105C94 Transporter HUS01_19935 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HUS01_19945 ENOG4105DEF Extracellular solute-binding protein, family 5 HUS01_19950 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUS01_19955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUS01_19960 ENOG4105C3U ABC transporter HUS01_19965 ENOG4108JQ7 (ABC) transporter HUS01_19970 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUS01_19975 ENOG4105EMU Dehydrogenase HUS01_19985 ENOG4105GBT ABC transporter HUS01_19990 ENOG4105DRP amino acid AbC transporter HUS01_19995 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HUS01_20005 ENOG4105CHM Aminotransferase HUS01_20010 ENOG4105T38 integral membrane protein HUS01_20015 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HUS01_20020 ENOG4108T58 Mg2 transport protein CorA HUS01_20045 ENOG4105WQ6 Membrane HUS01_20050 ENOG4105HFT AraC family transcriptional regulator HUS01_20060 ENOG410630P Transcriptional regulator HUS01_20065 ENOG4105MSB protein, conserved in bacteria HUS01_20070 ENOG4108RCM Nitroreductase HUS01_20080 ENOG4108IQ3 PTS system HUS01_20090 ENOG4105F3R pts system mannose fructose sorbose family iid HUS01_20095 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUS01_20100 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HUS01_20105 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HUS01_20125 ENOG4105CUY Mechanosensitive ion channel HUS01_20145 ENOG4108GWT fimbrillin MatB HUS01_20155 ENOG4108N3D putative enzyme HUS01_20160 ENOG4106PYX Receptor HUS01_20170 ENOG4105ISV protein with bipartite regulator domain HUS01_20180 ENOG4105CK5 oxidoreductase HUS01_20190 ENOG4105EAA nucleoside HUS01_20195 ENOG4105C85 amino acid HUS01_20205 ENOG4108NS2 receptor HUS01_20210 ENOG4105C26 Dehydrogenase HUS01_20215 ENOG4105CJP fad dependent oxidoreductase HUS01_20225 ENOG4105CUB amino acid HUS01_20235 ENOG4105DGU Histone deacetylase HUS01_20245 ENOG4108UAJ Transcriptional regulator HUS01_20255 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HUS01_20270 ENOG4105CPC Aldo Keto reductase HUS01_20275 ENOG4105E89 ABC transporter HUS01_20280 ENOG4105CH2 amidohydrolase HUS01_20310 ENOG4105EHG Permease protein HUS01_20315 ENOG4105E0A ABC, transporter HUS01_20320 ENOG4105EFX secretion protein, HlyD family HUS01_20325 ENOG4105KK7 inner membrane protein YiaW HUS01_20335 ENOG4105D7K pfkb domain protein HUS01_20340 ENOG4108M0B Sucrose porin HUS01_20345 ENOG4105C5Y PTS System HUS01_20350 ENOG4108HKT sucrose-6-phosphate hydrolase HUS01_20355 ENOG4105WBN Transcriptional regulator (LacI family HUS01_20365 ENOG4105CNN ABC, transporter HUS01_20370 ENOG4105C2J ABC transporter HUS01_20410 ENOG4105CRK lysyL-tRNA synthetase HUS01_20415 ENOG4105DUX Transporter HUS01_20420 ENOG4105CXN decarboxylase HUS01_20425 ENOG4105D5Q Arginine ornithine antiporter HUS01_20430 ENOG4108M3R transcriptional activator CadC HUS01_20440 ENOG4105D1S lipid A biosynthesis HUS01_20455 ENOG4105CW0 outer membrane usher protein HUS01_20460 ENOG4105GQR Chaperone HUS01_20465 ENOG4105X0I Fimbrial HUS01_20480 ENOG4105BZN citrate synthase HUS01_20510 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HUS01_20515 ENOG4105WQ3 Rna-binding protein HUS01_20520 ENOG4105C8N cysteinyl-tRNA synthetase HUS01_20525 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HUS01_20530 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HUS01_20540 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HUS01_20545 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HUS01_20565 ENOG4105CV6 ABC transporter, permease HUS01_20570 ENOG4108I0Y (ABC) transporter HUS01_20575 ENOG4108UJV acyl-CoA thioesterase i HUS01_20580 ENOG4105E1F short-chain dehydrogenase reductase HUS01_20585 ENOG4107QR8 Thioredoxin HUS01_20590 ENOG4105C4B ABC transporter, permease HUS01_20595 ENOG41083J0 (ABC) transporter HUS01_20600 ENOG4107QX8 SPFH domain, Band 7 family protein HUS01_20605 ENOG4105G5H Membrane HUS01_20610 ENOG4108Z6Z Transcriptional regulator HUS01_20615 ENOG4105C59 p-type ATPase HUS01_20620 ENOG4105MBR gumn family HUS01_20625 ENOG4108Z66 YbaK ebsC protein HUS01_20630 ENOG4105CGH 5'-nucleotidase HUS01_20635 ENOG4105EU0 Major facilitator Superfamily HUS01_20640 ENOG4105CKD glutathione-regulated potassium-efflux system protein HUS01_20645 ENOG4107RE1 Inosine-guanosine kinase HUS01_20655 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUS01_20660 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HUS01_20665 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HUS01_20670 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HUS01_20675 ENOG4107QMP dna polymerase iii subunits gamma and tau HUS01_20680 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HUS01_20685 ENOG4105WD1 Membrane HUS01_20690 ENOG4108URS primosomal replication protein n'' HUS01_20695 ENOG4106428 Protein of unknown function (DUF2496) HUS01_20700 ENOG4105DNE Transposase HUS01_20705 ENOG4105EGS Mechanosensitive ion channel HUS01_20725 ENOG4105C1P efflux transporter, rnd family, mfp subunit HUS01_20730 ENOG4105BZS acriflavin resistance protein HUS01_20735 ENOG4108UKR Biofilm formation regulator YbaJ HUS01_20745 ENOG4108UW5 maltose o-acetyltransferase HUS01_20755 ENOG4105GSJ Inner membrane protein ylaC HUS01_20770 ENOG4105YK5 50S ribosomal protein L36 HUS01_20780 ENOG4105ETE Transcriptional regulator (LacI family HUS01_20785 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HUS01_20790 ENOG4105CI1 PTS System HUS01_20795 ENOG4105C4C beta-galactosidase HUS01_20805 ENOG4105EG2 ABC transporter, permease HUS01_20815 ENOG4107FKK extracellular solute-binding protein family 1 HUS01_20825 ENOG41066DG (EAL) domain protein HUS01_20830 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter HUS01_20835 ENOG41061MD high-affinity nickel-transporter HUS01_20840 ENOG4108VW9 Membrane HUS01_20870 ENOG41080UX Methyltransferase HUS01_20875 ENOG4108MNP Glycoprotein polysaccharide metabolism HUS01_20880 ENOG4105C29 acyl-CoA thioesterase HUS01_20885 ENOG4105BZU Histidine kinase HUS01_20890 ENOG4108YZA Nitrogen regulatory protein pii HUS01_20895 ENOG4105BZ1 (ABC) transporter HUS01_20900 ENOG4105BZ1 (ABC) transporter HUS01_20905 ENOG4108XM1 transcriptional regulator AsnC family HUS01_20915 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HUS01_20920 ENOG4108NFA extracellular solute-binding protein HUS01_20925 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HUS01_20930 ENOG4108TGP Thioesterase superfamily protein HUS01_20935 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HUS01_20940 ENOG4105EIN peptidylprolyl cis-trans isomerase HUS01_20945 ENOG4105K70 DNA-binding protein HUS01_20950 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUS01_20955 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUS01_20965 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HUS01_20970 ENOG4105M85 Bola protein HUS01_20975 ENOG4105IEY (LipO)protein HUS01_20980 ENOG4105EYM Major Facilitator superfamily HUS01_20985 ENOG4105E2S oxidase) subunit II HUS01_20990 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUS01_20995 ENOG4105CCU oxidase (Subunit III) HUS01_21000 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HUS01_21005 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUS01_21015 ENOG4107HP6 Transcriptional regulator HUS01_21020 ENOG4105E2X shikimate dehydrogenase HUS01_21025 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HUS01_21035 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HUS01_21045 ENOG4105D2S major facilitator superfamily HUS01_21050 ENOG4105CIB oxidoreductase Domain protein HUS01_21055 ENOG4107RDB Major Facilitator HUS01_21065 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HUS01_21070 ENOG4107S0N DJ-1 family HUS01_21080 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HUS01_21085 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUS01_21090 ENOG4105CTB Polyprenyl synthetase HUS01_21095 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUS01_21100 ENOG4105CPC Aldo Keto reductase HUS01_21105 ENOG4108ZAI phosphatidylglycerophosphatase a HUS01_21110 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HUS01_21115 ENOG4107YIM Involved in the transcription termination process (By similarity) HUS01_21120 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HUS01_21125 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HUS01_21130 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HUS01_21135 ENOG4108KIC (LipO)protein HUS01_21140 ENOG4105DRB nucleoside-specific channel-forming protein HUS01_21155 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUS01_21160 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUS01_21165 ENOG4105VIE preprotein translocase, subunit YajC HUS01_21170 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HUS01_21175 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HUS01_21185 ENOG4108ZYK Acyl carrier protein phosphodiesterase HUS01_21190 ENOG4105D3R alkyl hydroperoxide reductase HUS01_21200 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HUS01_21215 ENOG4108MGF sugar kinase HUS01_21225 ENOG4105CI2 imidazolone-5-propionate hydrolase HUS01_21235 ENOG4105CHJ isochorismatase hydrolase HUS01_21240 ENOG4105EQ1 Transcriptional regulator HUS01_21245 ENOG4107R28 alpha amylase, catalytic region HUS01_21250 ENOG4105C85 amino acid HUS01_21255 ENOG4105CWM branched-chain amino acid transport system II carrier protein HUS01_21260 ENOG4105BZU Histidine kinase HUS01_21265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUS01_21270 ENOG4107RH8 nuclease SbcCD subunit D HUS01_21275 ENOG4105EYH Exonuclease HUS01_21280 ENOG4105DKQ ROK family HUS01_21285 ENOG4105DH7 May be involved in recombination (By similarity) HUS01_21290 ENOG4105NBK UPF0345 protein HUS01_21295 ENOG4105HBA AroM protein HUS01_21300 ENOG4105SS3 HUS01_21305 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HUS01_21310 ENOG4105G4C Periplasmic ligand-binding sensor protein HUS01_21315 ENOG4108UPT UPF0178 protein HUS01_21320 ENOG4105II7 pyrroline-5-carboxylate reductase HUS01_21325 ENOG4105VIF phosphate starvation-inducible protein HUS01_21330 ENOG4105G6Z alkaline phosphatase HUS01_21350 ENOG4105CPF Cell wall formation (By similarity) HUS01_21355 ENOG4105UNH Membrane HUS01_21360 ENOG4105FR5 inner membrane protein YaiY HUS01_21365 ENOG4107QS8 (LipO)protein HUS01_21370 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HUS01_21375 ENOG4108RWI nicotinamidase HUS01_21380 ENOG4107R6D beta-lactam binding protein AmpH HUS01_21385 ENOG4105D52 delta-aminolevulinic acid dehydratase HUS01_21395 ENOG4105E2B Taurine dioxygenase HUS01_21400 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUS01_21405 ENOG4108ETV ABC transporter HUS01_21410 ENOG4106FTQ Taurine ABC transporter, periplasmic HUS01_21415 ENOG4107QK5 Homocysteine s-methyltransferase HUS01_21420 ENOG4108IQI permease HUS01_21430 ENOG4105C85 amino acid HUS01_21435 ENOG4105CPD ethanolamine ammonia-lyase HUS01_21440 ENOG4107FQ9 ethanolamine ammonia-lyase HUS01_21455 ENOG4105C32 Amino acid ABC transporter (Permease) HUS01_21460 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HUS01_21465 ENOG4105C0Z ABC transporter HUS01_21470 ENOG4108IV0 ABC, transporter HUS01_21480 ENOG4105CT1 (ABC) transporter HUS01_21485 ENOG4105CDA abc transporter atp-binding protein HUS01_21490 ENOG4105E5Q amino acid AbC transporter HUS01_21495 ENOG4105DRP amino acid AbC transporter HUS01_21505 ENOG4106PYX Receptor HUS01_21510 ENOG4108N3D putative enzyme HUS01_21515 ENOG4108NN8 Fimbrial protein HUS01_21520 ENOG4108GWT fimbrillin MatB HUS01_21525 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon HUS01_21540 ENOG4105EHI Phosphonate ABC transporter, periplasmic HUS01_21550 ENOG4105S7S phosphonate abc transporter HUS01_21570 ENOG4108QBX (LipO)protein HUS01_21575 ENOG4105FCK Membrane HUS01_21580 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HUS01_21585 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HUS01_21595 ENOG4105DFP Integrase HUS01_21600 ENOG4107QJE Chromosome Partitioning Protein HUS01_21615 ENOG4105ZTC transcriptional activator, Ogr delta HUS01_21660 ENOG4107R0V Pyruvate dehydrogenase HUS01_21665 ENOG4105CPP Dehydrogenase, E1 component HUS01_21685 ENOG41061GT Aldolase HUS01_21695 ENOG4105CMG Carbohydrate kinase HUS01_21700 ENOG4105CHR reductase HUS01_21705 ENOG4108JQ1 Dehydrogenase HUS01_21710 ENOG4105DT3 PTS system, galactitol-specific IIc component HUS01_21715 ENOG4108TGY Glutathione S-transferase HUS01_21720 ENOG4105DTA methyltransferase HUS01_21725 ENOG4105YCT UPF0386 protein HUS01_21735 ENOG4105D5U fad dependent oxidoreductase HUS01_21740 ENOG4105C26 Dehydrogenase HUS01_21745 ENOG4108JPW Aminotransferase HUS01_21750 ENOG4105C85 amino acid HUS01_21755 ENOG4108PVQ transcriptional regulator HUS01_21760 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HUS01_21765 ENOG4105V1F Fermentation respiration switch protein HUS01_21770 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HUS01_21775 ENOG4105CIN aminoacyl-histidine dipeptidase HUS01_21780 ENOG4108HYG acetyltransferase HUS01_21785 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUS01_21800 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HUS01_21805 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HUS01_21810 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HUS01_21815 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HUS01_21820 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HUS01_21825 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HUS01_21830 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HUS01_21835 ENOG4105E7A Glutamine amidotransferase HUS01_21840 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HUS01_21845 ENOG4107QPN acyl-Coa dehydrogenase HUS01_21850 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HUS01_21855 ENOG4108VP3 Lysine exporter protein (LysE YggA) HUS01_21860 ENOG41090KR LysR family transcriptional Regulator HUS01_21870 ENOG4107RZZ dna polymerase iii epsilon subunit HUS01_21875 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUS01_21880 ENOG4105D1A Methyltransferase HUS01_21885 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUS01_21890 ENOG4105E9H Lytic Murein transglycosylase HUS01_21895 ENOG4105F2W methyltransferase HUS01_21905 ENOG4105F27 Major Facilitator HUS01_21910 ENOG4105HEI LysR family (Transcriptional regulator HUS01_21915 ENOG4105CV8 reductase HUS01_21950 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HUS01_21955 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUS01_21960 ENOG4108UMI ABC transporter, permease HUS01_21965 ENOG4105D01 (LipO)protein HUS01_21970 ENOG4108R8X outer membrane lipoprotein HUS01_21975 ENOG4108R96 Methyltransferase, YaeB family HUS01_21980 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUS01_21985 ENOG4108UY0 (LipO)protein HUS01_21990 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HUS01_21995 ENOG4108YZN class I peptide chain release factor HUS01_22000 ENOG4108VWS Yaeq family HUS01_22005 ENOG4105W1I UPF0253 protein HUS01_22010 ENOG4105M1T rho-binding antiterminator HUS01_22015 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HUS01_22020 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HUS01_22025 ENOG4105CXN decarboxylase HUS01_22030 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HUS01_22035 ENOG4105C0B DNA polymerase III (alpha subunit) HUS01_22040 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUS01_22045 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HUS01_22050 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HUS01_22055 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HUS01_22060 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HUS01_22065 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HUS01_22075 ENOG4105DZP Membrane-associated zinc metalloprotease HUS01_22080 ENOG4105KNE Phosphatidate cytidylyltransferase HUS01_22090 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HUS01_22100 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HUS01_22105 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HUS01_22110 ENOG4105CE9 30S ribosomal protein S2 HUS01_22115 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HUS01_22120 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HUS01_22125 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HUS01_22130 ENOG4108T8E UPF0325 protein HUS01_22135 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HUS01_22140 ENOG4105C0H protease HUS01_22145 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HUS01_22150 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HUS01_22155 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUS01_22160 ENOG4105EN6 Membrane HUS01_22165 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HUS01_22170 ENOG4105CMQ Chloride channel HUS01_22175 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUS01_22180 ENOG4105S6R Iron-hydroxamate transporter permease subunit HUS01_22185 ENOG4105J76 Periplasmic binding protein HUS01_22190 ENOG4105E0A ABC, transporter HUS01_22200 ENOG4105BZ4 penicillin-binding protein HUS01_22295 ENOG4105CQ7 ATP-dependent helicase HUS01_22300 ENOG4107XID 2'-5' rna ligase HUS01_22305 ENOG4105PW4 Sugar fermentation stimulation protein homolog HUS01_22310 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HUS01_22315 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HUS01_22320 ENOG4105DJ0 Poly(A) Polymerase HUS01_22325 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HUS01_22330 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HUS01_22335 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HUS01_22340 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HUS01_22345 ENOG4107BJW polysaccharide deacetylase HUS01_22350 ENOG4108YTN IIa component HUS01_22355 ENOG4105E3A (ABC) transporter HUS01_22360 ENOG4105DA5 (ABC) transporter HUS01_22365 ENOG41077A9 carbonic anhydrase HUS01_22370 ENOG4108UGV hypoxanthine phosphoribosyltransferase HUS01_22380 ENOG4105DZG Dehydrogenase HUS01_22385 ENOG4105E3B Multicopper oxidase HUS01_22390 ENOG4108ZRK uncharacterized protein yacC HUS01_22415 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HUS01_22420 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HUS01_22425 ENOG4108ZIG UPF0231 protein HUS01_22430 ENOG4107QIJ Aconitate hydratase 2 HUS01_22435 ENOG4108NST exported protein HUS01_22450 ENOG4107QN2 dihydrolipoyl dehydrogenase HUS01_22455 ENOG4107QSN dihydrolipoamide acetyltransferase HUS01_22460 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUS01_22465 ENOG41073TP transcriptional regulator HUS01_22470 ENOG4105C85 amino acid HUS01_22475 ENOG4105CT4 transporter HUS01_22480 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HUS01_22485 ENOG4106A72 regulatory protein AmpE HUS01_22490 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HUS01_22495 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HUS01_22500 ENOG4108ZUW Major pilin subunit HUS01_22505 ENOG4107QHF type ii secretion system protein e HUS01_22510 ENOG4105D7Q type ii secretion system HUS01_22515 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HUS01_22520 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HUS01_22525 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HUS01_22530 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HUS01_22535 ENOG4105M6F mutator MutT protein HUS01_22540 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUS01_22545 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HUS01_22550 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HUS01_22555 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HUS01_22560 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HUS01_22565 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HUS01_22575 ENOG4105DFU Cell wall formation (By similarity) HUS01_22580 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HUS01_22585 ENOG4105CNI cell division protein FtsW HUS01_22595 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HUS01_22600 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HUS01_22605 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HUS01_22610 ENOG4105CJN penicillin-binding protein HUS01_22615 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HUS01_22620 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HUS01_22630 ENOG4107B7Y DNA-binding transcriptional regulator FruR HUS01_22635 ENOG4108ZP8 Acetolactate synthase small subunit HUS01_22640 ENOG4105C7K acetolactate synthase HUS01_22645 ENOG41064T2 transcriptional regulator, lysR family HUS01_22655 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUS01_22665 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUS01_22670 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUS01_22685 ENOG4105EMV Major Facilitator HUS01_22690 ENOG4105FF2 Type I DHQase HUS01_22695 ENOG4105C5Q Transcriptional regulator HUS01_22700 ENOG4105DJB Major Facilitator Superfamily HUS01_22705 ENOG4105S8Q sugar efflux transporter HUS01_22725 ENOG4106SMU thiamine transporter membrane protein HUS01_22735 ENOG4108KF1 Membrane HUS01_22740 ENOG41063TF transcriptional regulator (AraC HUS01_22745 ENOG4105EF1 ribulokinase HUS01_22750 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HUS01_22755 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HUS01_22760 ENOG4105CQ2 DNA polymerase HUS01_22765 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HUS01_22770 ENOG4105D3G Pseudouridine synthase HUS01_22780 ENOG4105D2K citrate carrier protein HUS01_22785 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUS01_22790 ENOG4106YYS transcriptional regulatory protein HUS01_22795 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HUS01_22800 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HUS01_22810 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HUS01_22815 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUS01_22825 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HUS01_22830 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HUS01_22835 ENOG4105CKD glutathione-regulated potassium-efflux system protein HUS01_22845 ENOG4105M5B (LipO)protein HUS01_22850 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUS01_22855 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUS01_22860 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUS01_22865 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HUS01_22870 ENOG4105CHY citrate lyase, alpha HUS01_22875 ENOG4105CI0 Citrate lyase HUS01_22880 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HUS01_22885 ENOG4105DUA (citrate (pro-3S)-lyase ligase HUS01_22890 ENOG4105D2K citrate carrier protein HUS01_22900 ENOG4107QSA Oxaloacetate decarboxylase HUS01_22905 ENOG4105D9Q decarboxylase (Beta subunit) HUS01_22910 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUS01_22915 ENOG4106YYS transcriptional regulatory protein HUS01_22920 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUS01_22925 ENOG4105EXG Transcriptional regulator HUS01_22935 ENOG4105DU0 nucleoside hydrolase HUS01_22940 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUS01_22945 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HUS01_22950 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HUS01_22960 ENOG4105DTN riboflavin biosynthesis protein ribF HUS01_22975 ENOG41063Z6 transcriptional regulator, lysR family HUS01_22980 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUS01_22985 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUS01_22990 ENOG4105CFG Acts as a chaperone (By similarity) HUS01_22995 ENOG4108WTA UPF0412 protein YaaI HUS01_23000 ENOG4108QUJ UPF0174 protein YaaW HUS01_23005 ENOG4106HK8 GPR1 FUN34 yaaH family protein HUS01_23010 ENOG4105CSH Transporter HUS01_23015 ENOG4108RIR Molybdenum cofactor biosynthesis protein HUS01_23020 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HUS01_23025 ENOG4105BZG amino acid carrier protein HUS01_23030 ENOG4105D1Q UPF0246 protein HUS01_23040 ENOG4105D98 threonine synthase HUS01_23045 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HUS01_23050 ENOG4105CFH Aspartokinase HUS01_23060 ENOG4106FVC RNA methyltransferase HUS01_23065 ENOG410759A HUS01_23070 ENOG41065U4 response regulator HUS01_23075 ENOG4105CT7 inner membrane cred family protein HUS01_23080 ENOG4105EB3 Histidine kinase HUS01_23085 ENOG4105E3W Two component transcriptional regulator (Winged helix family HUS01_23090 ENOG4108RH0 Crea protein HUS01_23095 ENOG4105UEI Transcriptional Regulator AraC Family HUS01_23100 ENOG4105CVJ phosphoglycerate mutase HUS01_23105 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HUS01_23110 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HUS01_23115 ENOG4107SC1 transglycosylase HUS01_23120 ENOG4105C5H ABC transporter HUS01_23125 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HUS01_23130 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HUS01_23135 ENOG4105EAC phosphoserine phosphatase HUS01_23140 ENOG41062Z9 Membrane HUS01_23145 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) HUS01_23160 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HUS01_23170 ENOG4105D9N nucleoside HUS01_23175 ENOG4105EYA deoxyribonuclease HUS01_23180 ENOG4108NRW Phospholipase, patatin family HUS01_23185 ENOG41075IC Protein of unknown function (DUF1328) HUS01_23190 ENOG4105K3G Periplasmic Protein HUS01_23195 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HUS01_23200 ENOG4105PAD Hydrolase HUS01_23205 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HUS01_23210 ENOG4108WPU DNA polymerase III subunit psi HUS01_23215 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HUS01_23235 ENOG4105YBH Protein of unknown function (DUF1435) HUS01_23245 ENOG4106TD9 Diguanylate cyclase HUS01_23250 ENOG4108819 ferric iron reductase HUS01_23255 ENOG4105CK1 PTS System HUS01_23260 ENOG4108UIN ybak prolyl-trna synthetase associated region HUS01_23265 ENOG4108T94 DNA-binding transcriptional activator BglJ HUS01_23270 ENOG4108N8T regulatoR HUS01_23280 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HUS01_23285 ENOG4105DWK Membrane HUS01_23290 ENOG4107XM3 UPF0442 protein HUS01_23295 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HUS01_23300 ENOG4106CVF DNA replication protein HUS01_23305 ENOG4105RI1 glycoprotein receptor HUS01_23315 ENOG4105DNE Transposase HUS01_23330 ENOG4105F3R pts system mannose fructose sorbose family iid HUS01_23335 ENOG4105ETZ PTS System HUS01_23340 ENOG4105KPI PTS system sorbose subfamily IIB component HUS01_23350 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HUS01_23355 ENOG4107QZW Altronate oxidoreductase HUS01_23360 ENOG4105CPQ Dehydrogenase HUS01_23365 ENOG410617M Transcriptional regulator HUS01_23370 ENOG4108I5G Major Facilitator superfamily HUS01_23380 ENOG4105XYF acetyltransferase HUS01_23385 ENOG4106KNT transcriptional regulator HUS01_23390 ENOG4108RTU Aldolase HUS01_23395 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HUS01_23425 ENOG4105DG4 malate L-lactate dehydrogenase HUS01_23440 ENOG4108V8F Transcriptional regulator, MarR family HUS01_23450 ENOG4105ERH Fumarylacetoacetate hydrolase HUS01_23460 ENOG4105C26 Dehydrogenase HUS01_23465 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HUS01_23480 ENOG4105CNV Aldolase HUS01_23490 ENOG4108NKV transcriptional regulator HUS01_23495 ENOG4105EFA 4-hydroxyphenylacetate HUS01_23500 ENOG4107UWN reductase HUS01_23530 ENOG4105D22 carbon starvation protein HUS01_23535 ENOG4105VCD cytoplasmic protein HUS01_23540 ENOG4105CKI cobalamin synthesis protein HUS01_23550 ENOG4105C26 Dehydrogenase HUS01_23555 ENOG4105DNE Transposase HUS01_23560 ENOG4106AXJ AraC family transcriptional regulator HUS01_23570 ENOG4106BRA Membrane HUS01_23575 ENOG41083G8 Multidrug resistance protein MdtM HUS01_23585 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HUS01_23590 ENOG4105CIZ coA-substrate-specific enzyme activase HUS01_23605 ENOG4105EFX secretion protein, HlyD family HUS01_23615 ENOG4106DIZ Domain of unknown function (DUF1127) HUS01_23620 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUS01_23630 ENOG41064T2 transcriptional regulator, lysR family HUS01_23635 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HUS01_23640 ENOG4105CNN ABC, transporter HUS01_23645 ENOG4105CNN ABC, transporter HUS01_23650 ENOG4105C2J ABC transporter HUS01_23655 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUS01_23665 ENOG4105D0S secretion protein (HlyD HUS01_23670 ENOG4105CJ1 ABC, transporter HUS01_23675 ENOG4105CMI transporter HUS01_23705 ENOG4105EZE Cupin 4 family protein HUS01_23720 ENOG4105GR3 Histidine kinase HUS01_23725 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUS01_23730 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HUS01_23735 ENOG410624V efflux system protein HUS01_23740 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HUS01_23745 ENOG4108IJF Heavy metal efflux pump, CzcA HUS01_23755 ENOG4105QNF Outer membrane lipoprotein HUS01_23760 ENOG4108XDN Transcriptional regulator HUS01_23770 ENOG4107FW0 short-chain dehydrogenase reductase HUS01_23785 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUS01_23805 ENOG4107SEY Conserved Protein HUS01_23810 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HUS01_23815 ENOG4105C93 Xylose Isomerase HUS01_23820 ENOG4105CT4 transporter HUS01_23825 ENOG4105DSG hydrolase family 43 HUS01_23900 ENOG4105ZTC transcriptional activator, Ogr delta HUS01_23925 ENOG4105F2I Transposase HUS01_23940 ENOG41077A9 carbonic anhydrase HUS01_23945 ENOG4105CHH sulfate transporter HUS01_23950 ENOG4105DQ4 alcohol dehydrogenase HUS01_23960 ENOG4105DRS transport system, permease HUS01_23965 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HUS01_23970 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUS01_23975 ENOG4108IJG ABC transporter substrate-binding protein HUS01_23980 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HUS01_23985 ENOG4105F0H myo-inositol catabolism protein HUS01_23995 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HUS01_24000 ENOG4105D7K pfkb domain protein HUS01_24005 ENOG4105CHC glucokinase (EC 2.7.1.2) HUS01_24010 ENOG4105DH8 myo-inositol catabolism HUS01_24015 ENOG4105C26 Dehydrogenase HUS01_24025 ENOG4105D7A ATP-binding protein HUS01_24030 ENOG4108K5H permease YjgP YjgQ family protein HUS01_24035 ENOG4108M8S permease YjgP YjgQ family protein HUS01_24040 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUS01_24045 ENOG4105MYG DNA polymerase iii, chi subunit HUS01_24050 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUS01_24055 ENOG4108MJ3 acetyltransferase HUS01_24060 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HUS01_24065 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HUS01_24075 ENOG4105FDP GntR family transcriptional regulator HUS01_24080 ENOG4105CSX c4-dicarboxylate anaerobic carrier HUS01_24085 ENOG4105CI2 imidazolone-5-propionate hydrolase HUS01_24090 ENOG4108KPW sugar kinase HUS01_24095 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HUS01_24100 ENOG4105XEP YhcH YjgK YiaL family protein HUS01_24110 ENOG4105CXT aspartate transcarbamylase HUS01_24115 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HUS01_24120 ENOG4105KME endoribonuclease L-psp HUS01_24130 ENOG4105D4X repressor HUS01_24135 ENOG4105C5Y PTS System HUS01_24140 ENOG4105CG3 alpha amylase, catalytic region HUS01_24145 ENOG4105CK1 PTS System HUS01_24150 ENOG4105F8D glycoside hydrolase family 4 HUS01_24170 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HUS01_24175 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HUS01_24180 ENOG4105K4U addiction module toxin, RelE StbE family HUS01_24190 ENOG4105EMD TRANSCRIPTIONal HUS01_24195 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HUS01_24210 ENOG41069H0 dihydroorotase EC 3.5.2.3 HUS01_24245 ENOG4108XVM Cytochrome b(562) HUS01_24250 ENOG4105CMS peptidase U62, modulator of DNA gyrase HUS01_24255 ENOG4105N42 UPF0307 protein HUS01_24275 ENOG4105DFU Cell wall formation (By similarity) HUS01_24280 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HUS01_24285 ENOG41062B0 ABC transporter, permease HUS01_24290 ENOG4107R9N ABC transporter HUS01_24295 ENOG4105C2J ABC transporter HUS01_24300 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HUS01_24305 ENOG4105F0N pyrophosphate phospho-hydrolase HUS01_24320 ENOG4108ZHD aig2 family HUS01_24325 ENOG4105MA0 exported protein HUS01_24330 ENOG4105CFU surface antigen HUS01_24340 ENOG4105C37 (CBS) domain HUS01_24350 ENOG41061GZ Protein of unknown function (DUF1107) HUS01_24355 ENOG4108UUE Transcriptional regulator HUS01_24360 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HUS01_24365 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HUS01_24370 ENOG4105KVH Transcriptional regulator HUS01_24375 ENOG4105ECR NmrA family HUS01_24385 ENOG4105DXC membrane HUS01_24390 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HUS01_24400 ENOG4108V1T peptidylprolyl cis-trans isomerase HUS01_24405 ENOG4105FHY Opacity-associated protein A HUS01_24410 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HUS01_24415 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUS01_24420 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HUS01_24425 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HUS01_24430 ENOG4105KIT UPF0379 protein yjfY HUS01_24455 ENOG4106ETB IIa component HUS01_24465 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HUS01_24480 ENOG4108MXZ Esterase HUS01_24485 ENOG4105WSB biofilm stress and motility protein A HUS01_24490 ENOG4105S17 UPF0379 protein yjfN HUS01_24495 ENOG4105CSU acyl-Coa dehydrogenase HUS01_24500 ENOG4105C2N RNA methyltransferase TrmH family group 3 HUS01_24505 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HUS01_24510 ENOG4105KPV Transcriptional regulator HUS01_24515 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUS01_24530 ENOG4105EPW hflc protein HUS01_24535 ENOG4107QJR hflk protein HUS01_24540 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HUS01_24550 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HUS01_24555 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HUS01_24560 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HUS01_24565 ENOG4105K8N protein family UPF0079, ATPase HUS01_24570 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HUS01_24575 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HUS01_24595 ENOG4106TNF Periplasmic binding protein HUS01_24600 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HUS01_24605 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUS01_24610 ENOG4105DJ4 phosphatidylserine decarboxylase HUS01_24615 ENOG4105EGS Mechanosensitive ion channel HUS01_24620 ENOG4107SC7 Inner membrane transporter yjeM HUS01_24625 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HUS01_24630 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HUS01_24635 ENOG4105E33 succinate dehydrogenase HUS01_24645 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HUS01_24655 ENOG4105KPY Small multidrug resistance protein HUS01_24660 ENOG4106BSU Entericidin B HUS01_24670 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HUS01_24675 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HUS01_24695 ENOG4105CW0 outer membrane usher protein HUS01_24715 ENOG4108MBX Secretion Protein HUS01_24720 ENOG4108JJA ABC, transporter HUS01_24730 ENOG4108ZVF (LipO)protein HUS01_24735 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HUS01_24745 ENOG4105DVH amino acid HUS01_24750 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HUS01_24755 ENOG4108IJ0 Aspartate ammonia-lyase HUS01_24760 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HUS01_24770 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HUS01_24775 ENOG4108SIC Transcriptional regulator HUS01_24805 ENOG4108TUY outer membrane protein PgaA HUS01_24810 ENOG4107BJW polysaccharide deacetylase HUS01_24815 ENOG4105CND Glycosyl transferase, family 2 HUS01_24830 ENOG4108ZCF integral membrane protein HUS01_24840 ENOG4105DVC DnaJ domain protein HUS01_24870 ENOG4105CT4 transporter HUS01_24875 ENOG4105F8D glycoside hydrolase family 4 HUS01_24880 ENOG4108K2B transcriptional regulator HUS01_24885 ENOG4105CSH Transporter HUS01_24890 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HUS01_24895 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HUS01_24900 ENOG4107RJJ Transcriptional regulator HUS01_24905 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HUS01_24910 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HUS01_24915 ENOG4105EKV Phosphonate metabolism protein HUS01_24920 ENOG4105FT8 Phosphonate metabolism HUS01_24925 ENOG4105ENV phosphonate C-P lyase system protein PhnK HUS01_24930 ENOG4105HRV phosphonate c-p lyase system protein phnl HUS01_24935 ENOG4105FD8 phosphonate metabolism protein PhnM HUS01_24940 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HUS01_24945 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HUS01_24955 ENOG4105BZU Histidine kinase HUS01_24960 ENOG4105C2J ABC transporter HUS01_24965 ENOG4105CNN ABC, transporter HUS01_24970 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUS01_25000 ENOG41082ND Uncharacterized protein yjcO HUS01_25005 ENOG4105CK2 sodium dicarboxylate symporter HUS01_25015 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUS01_25020 ENOG41062QD Membrane HUS01_25025 ENOG4107QN1 sodium solute HUS01_25040 ENOG4105CW0 outer membrane usher protein HUS01_25045 ENOG4108VCD Chaperone HUS01_25050 ENOG4105MX3 Fimbrial HUS01_25055 ENOG41067MG lrgb family HUS01_25065 ENOG4105CMU LysR family (Transcriptional regulator HUS01_25070 ENOG4105EEQ Na H antiporter HUS01_25075 ENOG4105C7N Xanthine uracil vitamin C permease HUS01_25080 ENOG4108K3A Glutathione S-transferase HUS01_25085 ENOG4108Z4X TRANSCRIPTIONal HUS01_25090 ENOG4108W3Q Transcriptional regulator HUS01_25095 ENOG4108M8H domain protein HUS01_25100 ENOG4105PMV Membrane HUS01_25125 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUS01_25130 ENOG4105ETE Transcriptional regulator (LacI family HUS01_25135 ENOG4105ECY inositol monophosphatase HUS01_25145 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HUS01_25160 ENOG4108DMH HTH_ARAC HUS01_25165 ENOG4107RNH Outer membrane receptor FepA HUS01_25170 ENOG4105E4C Lytic transglycosylase catalytic HUS01_25175 ENOG4108UUM single-stranded DNA-binding protein HUS01_25180 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUS01_25185 ENOG4105MSB protein, conserved in bacteria HUS01_25190 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HUS01_25200 ENOG4105CGF Aromatic amino acid aminotransferase HUS01_25205 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUS01_25210 ENOG4105CDU Replicative dna helicase HUS01_25215 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUS01_25220 ENOG4105P4Z Phage shock protein G HUS01_25225 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HUS01_25235 ENOG4105MYN Zinc uptake regulation protein HUS01_25240 ENOG4105VDW Csbd family HUS01_25250 ENOG4107R73 Mate efflux family protein HUS01_25255 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUS01_25260 ENOG41080IJ Diacylglycerol kinase HUS01_25265 ENOG4105E55 glycerol-3-phosphate acyltransferase HUS01_25270 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HUS01_25275 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HUS01_25280 ENOG4107W52 maltose operon periplasmic protein HUS01_25285 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HUS01_25290 ENOG4108IJ9 (ABC) transporter HUS01_25295 ENOG4107FKK extracellular solute-binding protein family 1 HUS01_25300 ENOG4105D56 permease protein HUS01_25305 ENOG4105EG2 ABC transporter, permease HUS01_25310 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HUS01_25315 ENOG4105CEM UPF0597 protein HUS01_25330 ENOG4105KME endoribonuclease L-psp HUS01_25340 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HUS01_25345 ENOG4107QP8 phosphohexose isomerase HUS01_25350 ENOG4105CFH Aspartokinase HUS01_25355 ENOG4105C09 Bile acid HUS01_25360 ENOG4108ZR5 Conserved Protein HUS01_25365 ENOG4105FE9 pseudouridine synthase HUS01_25370 ENOG4105DKT Transcriptional regulator HUS01_25375 ENOG4105CHR reductase HUS01_25380 ENOG4108XCU pts system HUS01_25385 ENOG4105KPI PTS system sorbose subfamily IIB component HUS01_25390 ENOG4105ETZ PTS System HUS01_25395 ENOG4105F3R pts system mannose fructose sorbose family iid HUS01_25400 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HUS01_25405 ENOG4105F9E Shikimate 5-dehydrogenase HUS01_25410 ENOG4105EAM Na Pi-cotransporter HUS01_25415 ENOG4105C3R Methionine synthase HUS01_25420 ENOG41069M3 Transcriptional regulator HUS01_25425 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HUS01_25430 ENOG4108I9X Isocitrate lyase HUS01_25435 ENOG4107QP3 malate synthase g HUS01_25440 ENOG4105CVG Homoserine O-transsuccinylase HUS01_25445 ENOG4105K5X acetyltransferase HUS01_25470 ENOG4105DC1 bifunctional purine biosynthesis protein purh HUS01_25475 ENOG4105C12 Phosphoribosylglycinamide synthetase HUS01_25485 ENOG4105BZU Histidine kinase HUS01_25490 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HUS01_25495 ENOG4108T8B Protein of unknown function (DUF1481) HUS01_25500 ENOG4105K70 DNA-binding protein HUS01_25505 ENOG4105R2J Conserved Protein HUS01_25510 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HUS01_25515 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HUS01_25520 ENOG4105E09 nadh pyrophosphatase HUS01_25525 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HUS01_25530 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HUS01_25535 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HUS01_25540 ENOG4105D06 uba thif-type nad fad binding protein HUS01_25545 ENOG4105WHD thiamine biosynthesis protein ThiS HUS01_25550 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUS01_25555 ENOG4105D41 biosynthesis protein thiH HUS01_25560 ENOG4106TD9 Diguanylate cyclase HUS01_25570 ENOG4105VCP PTS System HUS01_25575 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HUS01_25580 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUS01_25585 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUS01_25590 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HUS01_25595 ENOG4108VZM 50s ribosomal protein L10 HUS01_25600 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HUS01_25605 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HUS01_25610 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HUS01_25615 ENOG4105PM1 preprotein translocase subunit SecE HUS01_25620 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUS01_25645 ENOG4105CS9 pantothenic acid kinase HUS01_25650 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HUS01_25655 ENOG4105D4A Cell wall formation (By similarity) HUS01_25685 ENOG4108RR8 protoporphyrinogen oxidase HUS01_25690 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HUS01_25695 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HUS01_25700 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) HUS01_25705 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) HUS01_25710 ENOG4105CHU acetyl-coa acetyltransferase HUS01_25715 ENOG4107QK7 reductase HUS01_25720 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HUS01_25725 ENOG4105MDZ Transcriptional activator rfaH HUS01_25735 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HUS01_25740 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HUS01_25745 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUS01_25750 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HUS01_25755 ENOG4105JC1 sterol-binding domain protein HUS01_25760 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUS01_25765 ENOG4105CGY Dna recombination protein HUS01_25770 ENOG4107SXA Phosphorylase HUS01_25775 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HUS01_25780 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HUS01_25785 ENOG4105DZ2 Transcriptional regulator HUS01_25790 ENOG4105EMK carboxylate amino acid amine transporter HUS01_25795 ENOG4105DQF Hydrolase HUS01_25800 ENOG4108EUD Lysophospholipase HUS01_25805 ENOG410829K Lysine exporter protein (Lyse ygga) HUS01_25815 ENOG4105CCF Lysine exporter protein (Lyse ygga) HUS01_25820 ENOG4105C9U ATP-dependent DNA helicase RecQ HUS01_25825 ENOG4105HDD phospholipase HUS01_25830 ENOG4108VUY thioesterase Superfamily protein HUS01_25835 ENOG4105FR1 rard protein HUS01_25840 ENOG4107QUT magnesium and cobalt transport protein CorA HUS01_25845 ENOG4105C4R Atp-dependent dna helicase HUS01_25850 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HUS01_25855 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUS01_25860 ENOG4105CT0 Protein of unknown function, DUF484 HUS01_25870 ENOG4105S7Z (LipO)protein HUS01_25875 ENOG4105XQ6 frataxin-like protein HUS01_25880 ENOG4107T0K Adenylate cyclase HUS01_25885 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUS01_25890 ENOG41076E6 Uroporphyrinogen-III Synthase HUS01_25895 ENOG4105ECF c-methyltransferase HUS01_25900 ENOG410601J HemY protein HUS01_25925 ENOG4105C85 amino acid HUS01_25930 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HUS01_25935 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HUS01_25940 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HUS01_25945 ENOG4105EGZ biosynthesis protein HUS01_25950 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUS01_25955 ENOG4108WJ1 acetyltransferase HUS01_25960 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HUS01_25965 ENOG4105C1B dTDP-glucose 4-6-dehydratase HUS01_25970 ENOG4107QQG Dehydrogenase HUS01_25975 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HUS01_25980 ENOG4105SFE lipopolysaccharide biosynthesis protein HUS01_25985 ENOG4105ESV Glycosyl transferase, family 4 HUS01_25990 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HUS01_26000 ENOG4105C1J atp-dependent rna helicase HUS01_26005 ENOG4105C9X ppx gppa phosphatase HUS01_26020 ENOG4108UQV Membrane HUS01_26025 ENOG4105C4R Atp-dependent dna helicase HUS01_26030 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HUS01_26035 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HUS01_26040 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HUS01_26045 ENOG4105EMY transcriptional regulator HUS01_26050 ENOG4105C7B Threonine dehydratase HUS01_26055 ENOG4105C01 Dihydroxy-acid dehydratase HUS01_26060 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUS01_26065 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HUS01_26080 ENOG4105C0P Mg chelatase subunit ChlI HUS01_26085 ENOG4108WFC UPF0438 protein yifE HUS01_26140 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HUS01_26145 ENOG4108Y73 Membrane HUS01_26150 ENOG4105EJ2 Transcriptional regulator HUS01_26155 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HUS01_26160 ENOG4105C5Q Transcriptional regulator HUS01_26165 ENOG4105CH7 arginosuccinase HUS01_26170 ENOG4105CAS nag kinase HUS01_26175 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUS01_26190 ENOG4108MEK Metal-binding protein YodA HUS01_26195 ENOG4106R3P AraC family transcriptional regulator HUS01_26200 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HUS01_26205 ENOG4105DCT glycerol dehydrogenase HUS01_26210 ENOG4108Q5Y Membrane HUS01_26215 ENOG4105SYT Methylenetetrahydrofolate reductase HUS01_26220 ENOG4105CN8 Transcriptional regulator HUS01_26225 ENOG4108Z8I decarboxylase HUS01_26230 ENOG4105CGH 5'-nucleotidase HUS01_26240 ENOG4105CFH Aspartokinase HUS01_26245 ENOG4105C28 cystathionine HUS01_26250 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HUS01_26255 ENOG4105VFB Binds the 23S rRNA (By similarity) HUS01_26260 ENOG4105C25 Primosomal protein n' HUS01_26265 ENOG4105ETE Transcriptional regulator (LacI family HUS01_26270 ENOG41063M6 Cell Division Protein HUS01_26275 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HUS01_26285 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HUS01_26290 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HUS01_26295 ENOG4105CTQ phosphohexokinase HUS01_26300 ENOG41076HS cation diffusion facilitator family transporter HUS01_26305 ENOG4105FMW periplasmic HUS01_26310 ENOG4105E3W Two component transcriptional regulator (Winged helix family HUS01_26315 ENOG4105E0F Histidine kinase HUS01_26320 ENOG4108RPX mosc domain containing protein HUS01_26325 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HUS01_26330 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HUS01_26335 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HUS01_26340 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HUS01_26345 ENOG4105DET Rhamnulokinase HUS01_26350 ENOG4105DKG l-rhamnose isomerase HUS01_26355 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) HUS01_26360 ENOG4105D4B ABC, transporter HUS01_26365 ENOG4105C2J ABC transporter HUS01_26370 ENOG4105CNN ABC, transporter HUS01_26375 ENOG4105CNN ABC, transporter HUS01_26380 ENOG4105C0A alcohol dehydrogenase HUS01_26390 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HUS01_26435 ENOG4105D2N Aldolase HUS01_26450 ENOG4105CTQ phosphohexokinase HUS01_26460 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HUS01_26470 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HUS01_26475 ENOG4108MG3 formate dehydrogenase HUS01_26480 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HUS01_26490 ENOG41068KX affects formate dehydrogenase-N HUS01_26500 ENOG4105SUU thioesterase domain HUS01_26505 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HUS01_26510 ENOG4107S2Z UPF0761 membrane protein HUS01_26515 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HUS01_26520 ENOG4105CI3 gtp-binding protein typa HUS01_26525 ENOG4105C5F glutamine synthetase HUS01_26530 ENOG4105CUX Signal transduction histidine kinase HUS01_26535 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HUS01_26540 ENOG4106FIY HUS01_26545 ENOG4105D4P Coproporphyrinogen iii oxidase HUS01_26550 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HUS01_26555 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HUS01_26560 ENOG4105C2M dna polymerase I HUS01_26565 ENOG4106HNH Acyl-transferase HUS01_26570 ENOG4108Z33 Thiol disulfide Interchange Protein HUS01_26575 ENOG4105E27 serine threonine protein kinase HUS01_26580 ENOG4105PC1 Conserved Protein HUS01_26585 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HUS01_26590 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HUS01_26615 ENOG4107EJG GntR family transcriptional regulator HUS01_26620 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUS01_26625 ENOG4105ETE Transcriptional regulator (LacI family HUS01_26630 ENOG4108RVA ribokinase HUS01_26635 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUS01_26640 ENOG4105CNN ABC, transporter HUS01_26645 ENOG4105C2J ABC transporter HUS01_26655 ENOG4105DFH Transport of potassium into the cell (By similarity) HUS01_26670 ENOG4105CU9 asparagine synthetase A HUS01_26675 ENOG4108VVK transcriptional Regulator, AsnC HUS01_26680 ENOG4105QTB Flavodoxin HUS01_26685 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HUS01_26690 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HUS01_26695 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HUS01_26715 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HUS01_26720 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HUS01_26725 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HUS01_26730 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HUS01_26735 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HUS01_26740 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HUS01_26745 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUS01_26750 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HUS01_26755 ENOG4105C8U phosphate abc transporter HUS01_26760 ENOG4105E2Z phosphate ABC transporter (Permease HUS01_26765 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUS01_26790 ENOG4105DYC esterase HUS01_26795 ENOG4107VKM 6-phosphogluconolactonase HUS01_26800 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HUS01_26805 ENOG4105C7N Xanthine uracil vitamin C permease HUS01_26810 ENOG4108YYH Nadph-dependent fmn reductase HUS01_26815 ENOG4105E8Q phosphopantetheinyl transferase HUS01_26825 ENOG4105C2C drug resistance transporter, Bcr CflA HUS01_26835 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HUS01_26840 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUS01_26845 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUS01_26855 ENOG4105VG0 50S ribosomal protein l34 HUS01_26965 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HUS01_26970 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUS01_26995 ENOG4105VUF Transcriptional regulator HUS01_27020 ENOG4105EQR Transposase IS116 IS110 IS902 HUS01_27075 ENOG4108Z3N Transcriptional regulator HUS01_27080 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) HUS01_27120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUS01_27165 ENOG4105MYN Zinc uptake regulation protein HUS01_27170 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUS01_27175 ENOG4105CKI cobalamin synthesis protein HUS01_27185 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase HUS01_27200 ENOG4105CKI cobalamin synthesis protein HUS01_27240 ENOG4105CD3 dihydroorotase HUS01_27245 ENOG4105D52 delta-aminolevulinic acid dehydratase HUS01_27330 ENOG4105DWP Membrane HUS01_27335 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HUS01_27355 ENOG4108WF3 methyltransferase HUS01_27390 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUS01_27400 ENOG4105EHG Permease protein HUS01_27420 ENOG4105CKI cobalamin synthesis protein HUS01_27475 ENOG4105DUU IucA IucC family protein HUS01_27480 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HUS01_27540 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HUS01_27590 ENOG4108XM1 transcriptional regulator AsnC family HUS01_27595 ENOG4105DWP Membrane HUS01_27625 ENOG4107U2T alpha beta HUS01_27695 ENOG4105DAX Pfam:DUF2983 HUS01_27715 ENOG4108M24 von Willebrand factor, type A HUS01_27725 ENOG4108M24 von Willebrand factor, type A HUS01_27730 ENOG4108M24 von Willebrand factor, type A HUS01_27750 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) HUS01_27770 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUS01_27810 ENOG4107SQD Transcriptional regulator, GntR family HUS01_27845 ENOG4105KF5 hemolysin expression-modulating protein HUS01_27905 ENOG4105E5H Transposase HUS01_27910 ENOG4108YXQ IS66 Orf2 family protein HUS01_27975 ENOG4108BUD transposase HUS01_28005 ENOG4108BUD transposase HUS01_28015 ENOG4108BUD transposase HUS01_28050 ENOG4108BUD transposase HUS01_28095 ENOG41073YN Protein of unknown function (DUF1380) HUS01_28125 ENOG4105EKQ RNA-directed DNA polymerase HUS01_28175 ENOG41074AV Hok/gef family HUS01_28205 ENOG4108BUD transposase HUS01_28225 ENOG4105MVE transcriptional regulator HUS01_28230 ENOG4108J4B Beta-lactamase HUS01_28300 ENOG4108BUD transposase HUS01_28310 ENOG4105BZU Histidine kinase HUS01_28340 ENOG4108VSE mercuric transport protein HUS01_28345 ENOG4105W1Y Transcriptional regulator HUS01_28350 ENOG4105EQR Transposase IS116 IS110 IS902 HUS01_28355 ENOG4105GR3 Histidine kinase HUS01_28360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUS01_28365 ENOG4108PG2 copper resistance HUS01_28370 ENOG4105JDN Copper resistance protein HUS01_28375 ENOG4105VR0 copper resistance HUS01_28380 ENOG4105E3B Multicopper oxidase HUS01_28390 ENOG4105DR5 peptidase HUS01_28420 ENOG410624V efflux system protein HUS01_28455 ENOG4105BZU Histidine kinase HUS01_28525 ENOG4105EKQ RNA-directed DNA polymerase HUS01_28555 ENOG41073YN Protein of unknown function (DUF1380) HUS01_28560 ENOG4106JQ7 HUS01_28580 ENOG4105MPK DNA polymerase III subunit theta HUS01_28605 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUS01_28645 ENOG41074AV Hok/gef family HUS01_28740 ENOG4108BUD transposase HUS01_28755 ENOG4107CBI conjugal transfer fertility inhibition protein HUS01_28780 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) HUS01_28810 ENOG4105EQR Transposase IS116 IS110 IS902 HUS01_28820 ENOG4108BUD transposase HUS01_28840 ENOG4108BUD transposase HUS01_28860 ENOG4105EKQ RNA-directed DNA polymerase HUS01_28975 ENOG4105CZX twitching motility protein HUS01_28990 ENOG4105K5T PilT protein HUS01_29015 ENOG4105BZU Histidine kinase HUS01_29095 ENOG4108YGG dna repair protein HUS01_29205 ENOG4105CJN penicillin-binding protein HUS01_29220 ENOG4108KTG Membrane protein, drug metabolite transporter HUS01_29235 ENOG4108BUD transposase HUS01_29250 ENOG4108BUD transposase HUS01_29275 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HUS01_29285 ENOG4105EKQ RNA-directed DNA polymerase