locus-tag class description HH204_00005 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HH204_00010 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HH204_00015 ENOG4105CJN penicillin-binding protein HH204_00020 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HH204_00025 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HH204_00035 ENOG4107B7Y DNA-binding transcriptional regulator FruR HH204_00040 ENOG4108ZP8 Acetolactate synthase small subunit HH204_00050 ENOG41064T2 transcriptional regulator, lysR family HH204_00065 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HH204_00075 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HH204_00080 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HH204_00095 ENOG4105EMV Major Facilitator HH204_00100 ENOG4105FF2 Type I DHQase HH204_00110 ENOG4105DJB Major Facilitator Superfamily HH204_00115 ENOG4105S8Q sugar efflux transporter HH204_00140 ENOG4106SMU thiamine transporter membrane protein HH204_00150 ENOG4108KF1 Membrane HH204_00155 ENOG41063TF transcriptional regulator (AraC HH204_00165 ENOG4105EF1 ribulokinase HH204_00170 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HH204_00175 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HH204_00180 ENOG4105CQ2 DNA polymerase HH204_00185 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HH204_00190 ENOG4105D3G Pseudouridine synthase HH204_00200 ENOG4105D2K citrate carrier protein HH204_00205 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HH204_00210 ENOG4106YYS transcriptional regulatory protein HH204_00215 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HH204_00220 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HH204_00230 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HH204_00235 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HH204_00245 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HH204_00250 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HH204_00255 ENOG4105CKD glutathione-regulated potassium-efflux system protein HH204_00265 ENOG4105M5B (LipO)protein HH204_00270 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HH204_00275 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HH204_00285 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HH204_00290 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HH204_00295 ENOG4105CHY citrate lyase, alpha HH204_00300 ENOG4105CI0 Citrate lyase HH204_00305 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HH204_00310 ENOG4105DUA (citrate (pro-3S)-lyase ligase HH204_00315 ENOG4105D2K citrate carrier protein HH204_00325 ENOG4107QSA Oxaloacetate decarboxylase HH204_00330 ENOG4105D9Q decarboxylase (Beta subunit) HH204_00335 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HH204_00340 ENOG4106YYS transcriptional regulatory protein HH204_00345 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HH204_00350 ENOG4105EXG Transcriptional regulator HH204_00360 ENOG4105DU0 nucleoside hydrolase HH204_00365 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HH204_00370 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HH204_00375 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HH204_00385 ENOG4105DTN riboflavin biosynthesis protein ribF HH204_00405 ENOG41063Z6 transcriptional regulator, lysR family HH204_00410 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HH204_00415 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HH204_00420 ENOG4105CFG Acts as a chaperone (By similarity) HH204_00425 ENOG4108WTA UPF0412 protein YaaI HH204_00430 ENOG4108QUJ UPF0174 protein YaaW HH204_00435 ENOG4106HK8 GPR1 FUN34 yaaH family protein HH204_00440 ENOG4105CSH Transporter HH204_00445 ENOG4108RIR Molybdenum cofactor biosynthesis protein HH204_00450 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HH204_00455 ENOG4105BZG amino acid carrier protein HH204_00460 ENOG4105D1Q UPF0246 protein HH204_00470 ENOG4105D98 threonine synthase HH204_00475 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HH204_00480 ENOG4105CFH Aspartokinase HH204_00495 ENOG4106FVC RNA methyltransferase HH204_00500 ENOG410759A HH204_00505 ENOG41065U4 response regulator HH204_00510 ENOG4105CT7 inner membrane cred family protein HH204_00515 ENOG4105EB3 Histidine kinase HH204_00520 ENOG4105E3W Two component transcriptional regulator (Winged helix family HH204_00525 ENOG4108RH0 Crea protein HH204_00530 ENOG4105UEI Transcriptional Regulator AraC Family HH204_00535 ENOG4105CVJ phosphoglycerate mutase HH204_00540 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HH204_00545 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HH204_00550 ENOG4107SC1 transglycosylase HH204_00555 ENOG4105C5H ABC transporter HH204_00560 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HH204_00565 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HH204_00570 ENOG4105EAC phosphoserine phosphatase HH204_00575 ENOG41062Z9 Membrane HH204_00580 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) HH204_00595 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HH204_00605 ENOG4105D9N nucleoside HH204_00610 ENOG4105EYA deoxyribonuclease HH204_00615 ENOG4108NRW Phospholipase, patatin family HH204_00620 ENOG41075IC Protein of unknown function (DUF1328) HH204_00625 ENOG4105K3G Periplasmic Protein HH204_00630 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HH204_00635 ENOG4105PAD Hydrolase HH204_00640 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HH204_00645 ENOG4108WPU DNA polymerase III subunit psi HH204_00650 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HH204_00670 ENOG4105YBH Protein of unknown function (DUF1435) HH204_00680 ENOG4106TD9 Diguanylate cyclase HH204_00685 ENOG4108819 ferric iron reductase HH204_00690 ENOG4105CK1 PTS System HH204_00695 ENOG4108UIN ybak prolyl-trna synthetase associated region HH204_00700 ENOG4108T94 DNA-binding transcriptional activator BglJ HH204_00705 ENOG4108N8T regulatoR HH204_00715 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HH204_00720 ENOG4105DWK Membrane HH204_00725 ENOG4107XM3 UPF0442 protein HH204_00730 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HH204_00735 ENOG4106CVF DNA replication protein HH204_00740 ENOG4105RI1 glycoprotein receptor HH204_00750 ENOG4105DNE Transposase HH204_00760 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HH204_00765 ENOG4105F3R pts system mannose fructose sorbose family iid HH204_00770 ENOG4105ETZ PTS System HH204_00775 ENOG4105KPI PTS system sorbose subfamily IIB component HH204_00785 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH204_00790 ENOG4107QZW Altronate oxidoreductase HH204_00795 ENOG4105CPQ Dehydrogenase HH204_00800 ENOG410617M Transcriptional regulator HH204_00805 ENOG4108I5G Major Facilitator superfamily HH204_00815 ENOG4105XYF acetyltransferase HH204_00820 ENOG4106KNT transcriptional regulator HH204_00825 ENOG4108RTU Aldolase HH204_00830 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HH204_00860 ENOG4105DG4 malate L-lactate dehydrogenase HH204_00875 ENOG4108V8F Transcriptional regulator, MarR family HH204_00885 ENOG4105ERH Fumarylacetoacetate hydrolase HH204_00895 ENOG4105C26 Dehydrogenase HH204_00900 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HH204_00915 ENOG4105CNV Aldolase HH204_00925 ENOG4108NKV transcriptional regulator HH204_00930 ENOG4105EFA 4-hydroxyphenylacetate HH204_00935 ENOG4107UWN reductase HH204_00960 ENOG4105D22 carbon starvation protein HH204_00965 ENOG4105VCD cytoplasmic protein HH204_00970 ENOG4105CKI cobalamin synthesis protein HH204_00980 ENOG4105C26 Dehydrogenase HH204_00985 ENOG4105DNE Transposase HH204_00990 ENOG4106AXJ AraC family transcriptional regulator HH204_01000 ENOG4106BRA Membrane HH204_01005 ENOG41083G8 Multidrug resistance protein MdtM HH204_01015 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HH204_01020 ENOG4105CIZ coA-substrate-specific enzyme activase HH204_01035 ENOG4105EFX secretion protein, HlyD family HH204_01045 ENOG4106DIZ Domain of unknown function (DUF1127) HH204_01050 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HH204_01065 ENOG41064T2 transcriptional regulator, lysR family HH204_01070 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HH204_01075 ENOG4105CNN ABC, transporter HH204_01080 ENOG4105CNN ABC, transporter HH204_01085 ENOG4105C2J ABC transporter HH204_01090 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HH204_01100 ENOG4105D0S secretion protein (HlyD HH204_01105 ENOG4105CJ1 ABC, transporter HH204_01110 ENOG4105CMI transporter HH204_01140 ENOG4105EZE Cupin 4 family protein HH204_01155 ENOG4105GR3 Histidine kinase HH204_01160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HH204_01165 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH204_01170 ENOG410624V efflux system protein HH204_01175 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HH204_01180 ENOG4108IJF Heavy metal efflux pump, CzcA HH204_01190 ENOG4105QNF Outer membrane lipoprotein HH204_01195 ENOG4108XDN Transcriptional regulator HH204_01205 ENOG4107FW0 short-chain dehydrogenase reductase HH204_01220 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HH204_01240 ENOG4107SEY Conserved Protein HH204_01245 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HH204_01255 ENOG4105C93 Xylose Isomerase HH204_01260 ENOG4105CT4 transporter HH204_01265 ENOG4105DSG hydrolase family 43 HH204_01285 ENOG4107S6X Glycosyl transferase, family 2 HH204_01340 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HH204_01345 ENOG4108XS9 dna repair protein HH204_01350 ENOG4105MFG Antirestriction protein HH204_01355 ENOG4106H6R UPF0380 protein HH204_01360 ENOG4106J9S Prophage HH204_01370 ENOG4108KZE transcriptional regulator HH204_01375 ENOG4108MXD gtp-binding protein HH204_01465 ENOG4105DZR Type I site-specific deoxyribonuclease HH204_01490 ENOG4105CVR type I restriction-modification system HH204_01510 ENOG41077A9 carbonic anhydrase HH204_01515 ENOG4105CHH sulfate transporter HH204_01520 ENOG4105DQ4 alcohol dehydrogenase HH204_01530 ENOG4105DRS transport system, permease HH204_01535 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HH204_01540 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HH204_01550 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HH204_01555 ENOG4105F0H myo-inositol catabolism protein HH204_01560 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HH204_01565 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HH204_01575 ENOG4105D7K pfkb domain protein HH204_01580 ENOG4105CHC glucokinase (EC 2.7.1.2) HH204_01585 ENOG4105DH8 myo-inositol catabolism HH204_01590 ENOG4105C26 Dehydrogenase HH204_01600 ENOG4105D7A ATP-binding protein HH204_01605 ENOG4108K5H permease YjgP YjgQ family protein HH204_01610 ENOG4108M8S permease YjgP YjgQ family protein HH204_01615 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HH204_01620 ENOG4105MYG DNA polymerase iii, chi subunit HH204_01625 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HH204_01630 ENOG4108MJ3 acetyltransferase HH204_01635 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HH204_01640 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HH204_01650 ENOG4105FDP GntR family transcriptional regulator HH204_01655 ENOG4105CSX c4-dicarboxylate anaerobic carrier HH204_01660 ENOG4105CI2 imidazolone-5-propionate hydrolase HH204_01665 ENOG4108KPW sugar kinase HH204_01670 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HH204_01680 ENOG4105XEP YhcH YjgK YiaL family protein HH204_01690 ENOG4105CXT aspartate transcarbamylase HH204_01695 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HH204_01700 ENOG4105KME endoribonuclease L-psp HH204_01710 ENOG4105D4X repressor HH204_01715 ENOG4105C5Y PTS System HH204_01720 ENOG4105CG3 alpha amylase, catalytic region HH204_01725 ENOG4105CK1 PTS System HH204_01730 ENOG4105F8D glycoside hydrolase family 4 HH204_01750 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HH204_01755 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HH204_01760 ENOG4105EMD TRANSCRIPTIONal HH204_01765 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HH204_01780 ENOG41069H0 dihydroorotase EC 3.5.2.3 HH204_01815 ENOG4108XVM Cytochrome b(562) HH204_01820 ENOG4105CMS peptidase U62, modulator of DNA gyrase HH204_01825 ENOG4105N42 UPF0307 protein HH204_01850 ENOG4105DFU Cell wall formation (By similarity) HH204_01855 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HH204_01860 ENOG41062B0 ABC transporter, permease HH204_01865 ENOG4107R9N ABC transporter HH204_01870 ENOG4105C2J ABC transporter HH204_01875 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HH204_01880 ENOG4105F0N pyrophosphate phospho-hydrolase HH204_01890 ENOG4108ZHD aig2 family HH204_01895 ENOG4105MA0 exported protein HH204_01900 ENOG4105CFU surface antigen HH204_01910 ENOG4105C37 (CBS) domain HH204_01920 ENOG4105C4C beta-galactosidase HH204_01930 ENOG41061GZ Protein of unknown function (DUF1107) HH204_01935 ENOG4108UUE Transcriptional regulator HH204_01940 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HH204_01945 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HH204_01950 ENOG4105KVH Transcriptional regulator HH204_01955 ENOG4105ECR NmrA family HH204_01965 ENOG4105DXC membrane HH204_01970 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HH204_01980 ENOG4108V1T peptidylprolyl cis-trans isomerase HH204_01985 ENOG4105FHY Opacity-associated protein A HH204_01990 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HH204_01995 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HH204_02000 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HH204_02005 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HH204_02010 ENOG4105KIT UPF0379 protein yjfY HH204_02035 ENOG4106ETB IIa component HH204_02045 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HH204_02060 ENOG4108MXZ Esterase HH204_02065 ENOG4105WSB biofilm stress and motility protein A HH204_02070 ENOG4105S17 UPF0379 protein yjfN HH204_02075 ENOG4105CSU acyl-Coa dehydrogenase HH204_02080 ENOG4105C2N RNA methyltransferase TrmH family group 3 HH204_02085 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HH204_02090 ENOG4105KPV Transcriptional regulator HH204_02095 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HH204_02110 ENOG4105EPW hflc protein HH204_02115 ENOG4107QJR hflk protein HH204_02120 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HH204_02130 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HH204_02135 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HH204_02145 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HH204_02150 ENOG4105K8N protein family UPF0079, ATPase HH204_02155 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HH204_02160 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HH204_02180 ENOG4106TNF Periplasmic binding protein HH204_02185 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HH204_02190 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HH204_02195 ENOG4105DJ4 phosphatidylserine decarboxylase HH204_02200 ENOG4105EGS Mechanosensitive ion channel HH204_02205 ENOG4107SC7 Inner membrane transporter yjeM HH204_02210 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HH204_02215 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HH204_02220 ENOG4105E33 succinate dehydrogenase HH204_02230 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HH204_02240 ENOG4105KPY Small multidrug resistance protein HH204_02245 ENOG4106BSU Entericidin B HH204_02255 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HH204_02260 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HH204_02280 ENOG4105CW0 outer membrane usher protein HH204_02295 ENOG4108MBX Secretion Protein HH204_02300 ENOG4108JJA ABC, transporter HH204_02310 ENOG4108ZVF (LipO)protein HH204_02315 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HH204_02325 ENOG4105DVH amino acid HH204_02330 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HH204_02335 ENOG4108IJ0 Aspartate ammonia-lyase HH204_02340 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HH204_02350 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HH204_02355 ENOG4108SIC Transcriptional regulator HH204_02390 ENOG4108TUY outer membrane protein PgaA HH204_02395 ENOG4107BJW polysaccharide deacetylase HH204_02400 ENOG4105CND Glycosyl transferase, family 2 HH204_02420 ENOG4108ZCF integral membrane protein HH204_02430 ENOG4105DVC DnaJ domain protein HH204_02455 ENOG4105CT4 transporter HH204_02460 ENOG4105F8D glycoside hydrolase family 4 HH204_02465 ENOG4108K2B transcriptional regulator HH204_02470 ENOG4105CSH Transporter HH204_02475 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HH204_02480 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HH204_02485 ENOG4107RJJ Transcriptional regulator HH204_02490 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HH204_02495 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HH204_02500 ENOG4105EKV Phosphonate metabolism protein HH204_02505 ENOG4105FT8 Phosphonate metabolism HH204_02510 ENOG4105ENV phosphonate C-P lyase system protein PhnK HH204_02515 ENOG4105HRV phosphonate c-p lyase system protein phnl HH204_02520 ENOG4105FD8 phosphonate metabolism protein PhnM HH204_02525 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HH204_02530 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HH204_02540 ENOG4105BZU Histidine kinase HH204_02545 ENOG4105C2J ABC transporter HH204_02550 ENOG4105CNN ABC, transporter HH204_02555 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HH204_02585 ENOG41082ND Uncharacterized protein yjcO HH204_02590 ENOG4105CK2 sodium dicarboxylate symporter HH204_02600 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HH204_02605 ENOG41062QD Membrane HH204_02610 ENOG4107QN1 sodium solute HH204_02625 ENOG4105CW0 outer membrane usher protein HH204_02630 ENOG4108VCD Chaperone HH204_02635 ENOG4105MX3 Fimbrial HH204_02645 ENOG41067MG lrgb family HH204_02655 ENOG4105CMU LysR family (Transcriptional regulator HH204_02660 ENOG4105EEQ Na H antiporter HH204_02665 ENOG4105C7N Xanthine uracil vitamin C permease HH204_02670 ENOG4108K3A Glutathione S-transferase HH204_02675 ENOG4108Z4X TRANSCRIPTIONal HH204_02680 ENOG4108W3Q Transcriptional regulator HH204_02685 ENOG4108M8H domain protein HH204_02690 ENOG4105PMV Membrane HH204_02715 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HH204_02720 ENOG4105ETE Transcriptional regulator (LacI family HH204_02725 ENOG4105ECY inositol monophosphatase HH204_02735 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HH204_02755 ENOG4108DMH HTH_ARAC HH204_02760 ENOG4107RNH Outer membrane receptor FepA HH204_02775 ENOG4105E4C Lytic transglycosylase catalytic HH204_02780 ENOG4108UUM single-stranded DNA-binding protein HH204_02785 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HH204_02790 ENOG4105MSB protein, conserved in bacteria HH204_02795 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HH204_02805 ENOG4105CGF Aromatic amino acid aminotransferase HH204_02810 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HH204_02815 ENOG4105CDU Replicative dna helicase HH204_02820 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HH204_02825 ENOG4105P4Z Phage shock protein G HH204_02830 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HH204_02840 ENOG4105MYN Zinc uptake regulation protein HH204_02845 ENOG4105VDW Csbd family HH204_02855 ENOG4107R73 Mate efflux family protein HH204_02860 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HH204_02865 ENOG41080IJ Diacylglycerol kinase HH204_02870 ENOG4105E55 glycerol-3-phosphate acyltransferase HH204_02875 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HH204_02880 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HH204_02885 ENOG4107W52 maltose operon periplasmic protein HH204_02890 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HH204_02895 ENOG4108IJ9 (ABC) transporter HH204_02900 ENOG4107FKK extracellular solute-binding protein family 1 HH204_02905 ENOG4105D56 permease protein HH204_02910 ENOG4105EG2 ABC transporter, permease HH204_02915 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HH204_02920 ENOG4105CEM UPF0597 protein HH204_02935 ENOG4105KME endoribonuclease L-psp HH204_02945 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HH204_02950 ENOG4107QP8 phosphohexose isomerase HH204_02955 ENOG4105CFH Aspartokinase HH204_02960 ENOG4105C09 Bile acid HH204_02965 ENOG4108ZR5 Conserved Protein HH204_02970 ENOG4105FE9 pseudouridine synthase HH204_02980 ENOG4105EAM Na Pi-cotransporter HH204_02985 ENOG4105C3R Methionine synthase HH204_02990 ENOG41069M3 Transcriptional regulator HH204_02995 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HH204_03000 ENOG4108I9X Isocitrate lyase HH204_03005 ENOG4107QP3 malate synthase g HH204_03010 ENOG4105CVG Homoserine O-transsuccinylase HH204_03015 ENOG4105K5X acetyltransferase HH204_03040 ENOG4105DC1 bifunctional purine biosynthesis protein purh HH204_03045 ENOG4105C12 Phosphoribosylglycinamide synthetase HH204_03055 ENOG4105BZU Histidine kinase HH204_03060 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HH204_03065 ENOG4108T8B Protein of unknown function (DUF1481) HH204_03070 ENOG4105K70 DNA-binding protein HH204_03075 ENOG4105R2J Conserved Protein HH204_03080 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HH204_03085 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HH204_03095 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HH204_03100 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HH204_03105 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HH204_03110 ENOG4105D06 uba thif-type nad fad binding protein HH204_03115 ENOG4105WHD thiamine biosynthesis protein ThiS HH204_03120 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HH204_03125 ENOG4105D41 biosynthesis protein thiH HH204_03130 ENOG4106TD9 Diguanylate cyclase HH204_03140 ENOG4105VCP PTS System HH204_03145 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HH204_03150 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HH204_03155 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HH204_03160 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HH204_03165 ENOG4108VZM 50s ribosomal protein L10 HH204_03170 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HH204_03175 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HH204_03180 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HH204_03185 ENOG4105PM1 preprotein translocase subunit SecE HH204_03190 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HH204_03215 ENOG4105CS9 pantothenic acid kinase HH204_03220 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HH204_03225 ENOG4105D4A Cell wall formation (By similarity) HH204_03255 ENOG4108RR8 protoporphyrinogen oxidase HH204_03260 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HH204_03265 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HH204_03270 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) HH204_03275 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) HH204_03280 ENOG4105CHU acetyl-coa acetyltransferase HH204_03285 ENOG4107QK7 reductase HH204_03290 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HH204_03300 ENOG4105MDZ Transcriptional activator rfaH HH204_03310 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HH204_03315 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HH204_03320 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HH204_03325 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HH204_03330 ENOG4105JC1 sterol-binding domain protein HH204_03335 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HH204_03340 ENOG4105CGY Dna recombination protein HH204_03345 ENOG4107SXA Phosphorylase HH204_03350 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HH204_03355 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HH204_03360 ENOG4105DZ2 Transcriptional regulator HH204_03365 ENOG4105EMK carboxylate amino acid amine transporter HH204_03370 ENOG4105DQF Hydrolase HH204_03375 ENOG4108EUD Lysophospholipase HH204_03380 ENOG410829K Lysine exporter protein (Lyse ygga) HH204_03390 ENOG4105CCF Lysine exporter protein (Lyse ygga) HH204_03395 ENOG4105C9U ATP-dependent DNA helicase RecQ HH204_03400 ENOG4105HDD phospholipase HH204_03405 ENOG4108VUY thioesterase Superfamily protein HH204_03410 ENOG4105FR1 rard protein HH204_03415 ENOG4107QUT magnesium and cobalt transport protein CorA HH204_03420 ENOG4105C4R Atp-dependent dna helicase HH204_03425 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HH204_03430 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HH204_03435 ENOG4105CT0 Protein of unknown function, DUF484 HH204_03445 ENOG4105S7Z (LipO)protein HH204_03450 ENOG4105XQ6 frataxin-like protein HH204_03455 ENOG4107T0K Adenylate cyclase HH204_03460 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HH204_03465 ENOG41076E6 Uroporphyrinogen-III Synthase HH204_03470 ENOG4105ECF c-methyltransferase HH204_03475 ENOG410601J HemY protein HH204_03505 ENOG4105C85 amino acid HH204_03510 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HH204_03515 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HH204_03525 ENOG4105EGZ biosynthesis protein HH204_03530 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HH204_03535 ENOG4108WJ1 acetyltransferase HH204_03540 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HH204_03545 ENOG4105C1B dTDP-glucose 4-6-dehydratase HH204_03550 ENOG4107QQG Dehydrogenase HH204_03555 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HH204_03560 ENOG4105SFE lipopolysaccharide biosynthesis protein HH204_03565 ENOG4105ESV Glycosyl transferase, family 4 HH204_03570 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HH204_03580 ENOG4105C1J atp-dependent rna helicase HH204_03585 ENOG4105C9X ppx gppa phosphatase HH204_03600 ENOG4108UQV Membrane HH204_03605 ENOG4105C4R Atp-dependent dna helicase HH204_03610 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HH204_03615 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HH204_03620 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HH204_03625 ENOG4105EMY transcriptional regulator HH204_03630 ENOG4105C7B Threonine dehydratase HH204_03635 ENOG4105C01 Dihydroxy-acid dehydratase HH204_03640 ENOG4105CM2 brancheD-chain amino acid aminotransferase HH204_03645 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HH204_03660 ENOG4105C0P Mg chelatase subunit ChlI HH204_03665 ENOG4108WFC UPF0438 protein yifE HH204_03720 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HH204_03725 ENOG4108Y73 Membrane HH204_03730 ENOG4105EJ2 Transcriptional regulator HH204_03735 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HH204_03740 ENOG4105C5Q Transcriptional regulator HH204_03745 ENOG4105CH7 arginosuccinase HH204_03750 ENOG4105CAS nag kinase HH204_03755 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HH204_03770 ENOG4108MEK Metal-binding protein YodA HH204_03775 ENOG4106R3P AraC family transcriptional regulator HH204_03780 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HH204_03785 ENOG4105DCT glycerol dehydrogenase HH204_03790 ENOG4108Q5Y Membrane HH204_03795 ENOG4105SYT Methylenetetrahydrofolate reductase HH204_03800 ENOG4105CN8 Transcriptional regulator HH204_03805 ENOG4108Z8I decarboxylase HH204_03810 ENOG4105CGH 5'-nucleotidase HH204_03820 ENOG4105CFH Aspartokinase HH204_03825 ENOG4105C28 cystathionine HH204_03830 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HH204_03835 ENOG4105VFB Binds the 23S rRNA (By similarity) HH204_03840 ENOG4105C25 Primosomal protein n' HH204_03845 ENOG4105ETE Transcriptional regulator (LacI family HH204_03850 ENOG41063M6 Cell Division Protein HH204_03855 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HH204_03865 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HH204_03870 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HH204_03875 ENOG4105CTQ phosphohexokinase HH204_03880 ENOG41076HS cation diffusion facilitator family transporter HH204_03885 ENOG4105FMW periplasmic HH204_03890 ENOG4105E3W Two component transcriptional regulator (Winged helix family HH204_03895 ENOG4105E0F Histidine kinase HH204_03900 ENOG4108RPX mosc domain containing protein HH204_03905 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HH204_03910 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HH204_03915 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HH204_03920 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HH204_03925 ENOG4105DET Rhamnulokinase HH204_03930 ENOG4105DKG l-rhamnose isomerase HH204_03935 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) HH204_03940 ENOG4105D4B ABC, transporter HH204_03945 ENOG4105C2J ABC transporter HH204_03950 ENOG4105CNN ABC, transporter HH204_03955 ENOG4105CNN ABC, transporter HH204_03960 ENOG4105C0A alcohol dehydrogenase HH204_03970 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HH204_04005 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HH204_04015 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HH204_04020 ENOG4108MG3 formate dehydrogenase HH204_04025 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HH204_04035 ENOG41068KX affects formate dehydrogenase-N HH204_04045 ENOG4105SUU thioesterase domain HH204_04050 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HH204_04055 ENOG4107S2Z UPF0761 membrane protein HH204_04060 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HH204_04065 ENOG4105CI3 gtp-binding protein typa HH204_04070 ENOG4105C5F glutamine synthetase HH204_04075 ENOG4105CUX Signal transduction histidine kinase HH204_04080 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH204_04085 ENOG4106FIY HH204_04090 ENOG4105D4P Coproporphyrinogen iii oxidase HH204_04095 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HH204_04100 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HH204_04105 ENOG4105C2M dna polymerase I HH204_04110 ENOG4106HNH Acyl-transferase HH204_04115 ENOG4108Z33 Thiol disulfide Interchange Protein HH204_04120 ENOG4105E27 serine threonine protein kinase HH204_04125 ENOG4105PC1 Conserved Protein HH204_04130 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HH204_04135 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HH204_04160 ENOG4107EJG GntR family transcriptional regulator HH204_04165 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH204_04170 ENOG4105ETE Transcriptional regulator (LacI family HH204_04175 ENOG4108RVA ribokinase HH204_04180 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HH204_04185 ENOG4105CNN ABC, transporter HH204_04190 ENOG4105C2J ABC transporter HH204_04200 ENOG4105DFH Transport of potassium into the cell (By similarity) HH204_04215 ENOG4105CU9 asparagine synthetase A HH204_04220 ENOG4108VVK transcriptional Regulator, AsnC HH204_04225 ENOG4105QTB Flavodoxin HH204_04230 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HH204_04235 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HH204_04240 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HH204_04260 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HH204_04265 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HH204_04270 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HH204_04275 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HH204_04280 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HH204_04300 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HH204_04305 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HH204_04310 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HH204_04315 ENOG4105C8U phosphate abc transporter HH204_04320 ENOG4105E2Z phosphate ABC transporter (Permease HH204_04325 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HH204_04345 ENOG4105DYC esterase HH204_04350 ENOG4107VKM 6-phosphogluconolactonase HH204_04355 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HH204_04365 ENOG4105C7N Xanthine uracil vitamin C permease HH204_04370 ENOG4108YYH Nadph-dependent fmn reductase HH204_04375 ENOG4105E8Q phosphopantetheinyl transferase HH204_04395 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HH204_04400 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HH204_04405 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HH204_04415 ENOG4105VG0 50S ribosomal protein l34 HH204_04425 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HH204_04430 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HH204_04435 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HH204_04440 ENOG410667J hydrolase HH204_04455 ENOG4105EMF GntR family transcriptional regulator HH204_04460 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HH204_04465 ENOG4108RTU Aldolase HH204_04470 ENOG4105CXK mandelate racemase muconate lactonizing HH204_04475 ENOG4105DJB Major Facilitator Superfamily HH204_04485 ENOG4105R2A (LipO)protein HH204_04505 ENOG4105D0C transport protein HH204_04510 ENOG4105FDP GntR family transcriptional regulator HH204_04515 ENOG4105CI1 PTS System HH204_04520 ENOG4105F8D glycoside hydrolase family 4 HH204_04525 ENOG4105VG5 Membrane HH204_04530 ENOG4105JP4 Inner membrane protein yidG HH204_04555 ENOG4105W8I Transcriptional regulator HH204_04560 ENOG4105E5M Multidrug resistance protein D HH204_04590 ENOG4105C7K acetolactate synthase HH204_04595 ENOG4105M71 acetolactate synthase 1 regulatory subunit HH204_04600 ENOG4108KX4 response regulator HH204_04605 ENOG4105BZU Histidine kinase HH204_04610 ENOG4105CXY transporter HH204_04615 ENOG4105CXY transporter HH204_04620 ENOG4108SAJ Protein of unknown function (DUF1198) HH204_04640 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HH204_04645 ENOG4107STF Involved in phosphonate degradation (By similarity) HH204_04650 ENOG4106S9K Transcriptional regulator HH204_04665 ENOG4108MP3 ABC transporter, permease HH204_04680 ENOG4105VCP PTS System HH204_04685 ENOG4105CK1 PTS System HH204_04695 ENOG4105ETE Transcriptional regulator (LacI family HH204_04700 ENOG4105D2S major facilitator superfamily HH204_04710 ENOG4107F9Y LysR family transcriptional regulator HH204_04720 ENOG4105JSC dimethylmenaquinone methyltransferase HH204_04730 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HH204_04735 ENOG4105T8A Uncharacterized protein YicS HH204_04740 ENOG4108UZ3 Transporter HH204_04745 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) HH204_04750 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HH204_04755 ENOG4105C2C drug resistance transporter, Bcr CflA HH204_04760 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH204_04765 ENOG4105BZS acriflavin resistance protein HH204_04770 ENOG4105C1P efflux transporter, rnd family, mfp subunit HH204_04790 ENOG410630P Transcriptional regulator HH204_04800 ENOG4105CR8 Transcriptional regulator HH204_04825 ENOG4105D01 (LipO)protein HH204_04840 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HH204_04850 ENOG4105DQ4 alcohol dehydrogenase HH204_04870 ENOG4105NI3 Protein of unknown function (DUF3237) HH204_04880 ENOG4105CT4 transporter HH204_04885 ENOG4105CJQ hydrolase, family 31 HH204_04895 ENOG4105F8D glycoside hydrolase family 4 HH204_04900 ENOG4105CI1 PTS System HH204_04905 ENOG4105JV1 AsmA family HH204_04910 ENOG4105C2W permease HH204_04915 ENOG4105D6U Sodium Glutamate Symporter HH204_04920 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HH204_04925 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HH204_04930 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HH204_04935 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HH204_04950 ENOG4105CP7 Triose-phosphate isomerase HH204_04955 ENOG4105EBK exported protein HH204_04960 ENOG4108VTS Membrane HH204_04965 ENOG4105DP0 ferredoxin-NADP reductase HH204_04970 ENOG4105CBT Fructose-1,6-bisphosphatase HH204_04975 ENOG4105CB5 ATP-dependent DNA helicase recG HH204_04980 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HH204_04985 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HH204_04995 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HH204_05000 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HH204_05005 ENOG4105EN6 Membrane HH204_05015 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HH204_05020 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) HH204_05030 ENOG4105DSJ YicC domain protein HH204_05055 ENOG4105CJ1 ABC, transporter HH204_05060 ENOG4107QWP ABC-2 type transporter HH204_05065 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HH204_05080 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HH204_05085 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HH204_05090 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HH204_05095 ENOG4105W5Q DNA repair protein (RadC HH204_05100 ENOG4105KDC 50s ribosomal protein l28 HH204_05105 ENOG4105W0E 50S ribosomal protein L33 HH204_05110 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HH204_05115 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HH204_05120 ENOG4106WTF Glycosyl transferase, family 2 HH204_05125 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HH204_05130 ENOG4105K64 Glycosyl transferase, family 2 HH204_05135 ENOG4105CPK Glycosyl transferase (Group 1 HH204_05145 ENOG4105DKP glycosyl transferase, family 9 HH204_05160 ENOG41068PG O-Antigen polymerase HH204_05170 ENOG4105D16 lipopolysaccharide heptosyltransferase i HH204_05175 ENOG4105XA0 heptosyltransferase ii HH204_05180 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HH204_05185 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HH204_05190 ENOG4105CPQ Dehydrogenase HH204_05195 ENOG4106WTF Glycosyl transferase, family 2 HH204_05200 ENOG4105PXI polysaccharide deacetylase HH204_05205 ENOG41063SB peptidase HH204_05215 ENOG4107YZP Rhodanese domain protein HH204_05220 ENOG4105VW4 glutaredoxin 3 HH204_05225 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HH204_05230 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HH204_05235 ENOG4105D7W serine acetyltransferase HH204_05240 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HH204_05245 ENOG4105DMF Dehydrogenase HH204_05250 ENOG41073TP transcriptional regulator HH204_05255 ENOG4105DAA L-lactate HH204_05260 ENOG4108YYI Protein of unknown function (DUF2810) HH204_05270 ENOG4105E61 Mannitol repressor protein HH204_05275 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HH204_05280 ENOG4105CTS PTS system mannitol-specific HH204_05290 ENOG4108U78 Glutathione S-transferase HH204_05295 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HH204_05305 ENOG4105J4Q Transcriptional regulator HH204_05310 ENOG4108RC0 Electron transport protein HH204_05315 ENOG4105JKW Valine--pyruvate aminotransferase HH204_05320 ENOG4107T9C Alpha amylase catalytic region HH204_05325 ENOG4108UR8 BAX protein HH204_05330 ENOG4105T16 Transcriptional regulator (AraC family) HH204_05335 ENOG4108HWW ABC transporter HH204_05345 ENOG4105DFW ABC transporter HH204_05350 ENOG4105C93 Xylose Isomerase HH204_05355 ENOG4105CMG Carbohydrate kinase HH204_05360 ENOG410688U Inner membrane protein yiaB HH204_05365 ENOG4108Z12 YiaAB two helix domain-containing protein HH204_05370 ENOG4105MEV Acyl-transferase HH204_05380 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HH204_05385 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HH204_05390 ENOG41060TC Hok gef cell toxic protein HH204_05405 ENOG4105MVF Transcriptional regulator HH204_05410 ENOG4105D2S major facilitator superfamily HH204_05415 ENOG4106JH6 (LipO)protein HH204_05420 ENOG4105C5I Dehydrogenase HH204_05430 ENOG4105D7K pfkb domain protein HH204_05440 ENOG4108M60 Transcriptional regulator HH204_05450 ENOG4108ZG0 Ompa motb domain protein HH204_05455 ENOG4107QY8 reductase HH204_05460 ENOG4105HNP -acetyltransferase HH204_05465 ENOG4108R3E Dna-3-methyladenine glycosylase i HH204_05470 ENOG4105EAX Putative lipase HH204_05475 ENOG4105FCD Major Facilitator HH204_05480 ENOG4105DIJ Phosphoethanolamine transferase HH204_05505 ENOG4105DEF Extracellular solute-binding protein, family 5 HH204_05510 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HH204_05515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HH204_05520 ENOG4105C3U ABC transporter HH204_05525 ENOG4108JQ7 (ABC) transporter HH204_05545 ENOG4107QZ7 Cellulose synthase catalytic subunit HH204_05570 ENOG4105D1V cellulose synthase operon protein YhjU HH204_05575 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT HH204_05580 ENOG4105U74 cellulose biosynthesis protein BcsE HH204_05585 ENOG410661M cytoplasmic protein HH204_05590 ENOG4105UTS cellulose synthase operon protein YhjQ HH204_05600 ENOG4107EEX Cellulose synthase regulator protein HH204_05605 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HH204_05610 ENOG4105EJG cellulose synthase HH204_05615 ENOG4105BZU Histidine kinase HH204_05620 ENOG4105CK2 sodium dicarboxylate symporter HH204_05625 ENOG4105CS0 peptidase HH204_05645 ENOG4105CSH Transporter HH204_05650 ENOG4107H3J ribonuclease HH204_05655 ENOG4105CBN LysR family transcriptional regulator HH204_05660 ENOG4105CHR reductase HH204_05675 ENOG4105C0A alcohol dehydrogenase HH204_05685 ENOG4105DC8 reductase HH204_05690 ENOG4105D6S protein involved in catabolism of external DNA HH204_05695 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HH204_05700 ENOG4105DGW oligopeptidase A HH204_05705 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HH204_05710 ENOG4105DUX Transporter HH204_05720 ENOG4108V6B universal stress protein B HH204_05725 ENOG4105CJ3 phosphate transporter HH204_05730 ENOG4105CBX hi0933 family HH204_05735 ENOG4105CJW magnesium transporter HH204_05750 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HH204_05760 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HH204_05765 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HH204_05770 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HH204_05780 ENOG4105PY6 Phenolic acid decarboxylase HH204_05785 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HH204_05790 ENOG4105CKK Glycosyl transferase, family 2 HH204_05795 ENOG4105C3I Nad-dependent epimerase dehydratase HH204_05800 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HH204_05805 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HH204_05810 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HH204_05815 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HH204_05820 ENOG4105DSF transport protein HH204_05825 ENOG4105F9N Major Facilitator Superfamily HH204_05830 ENOG4108W1V Lipoprotein HH204_05835 ENOG4105EX9 Membrane HH204_05840 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HH204_05850 ENOG4107FS9 Membrane HH204_05860 ENOG4105MG3 Membrane HH204_05865 ENOG4106H78 methyltransferase HH204_05870 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HH204_05875 ENOG4105CAK Cell division ATP-binding protein ftsE HH204_05880 ENOG4105CRP Part of the ABC transporter FtsEX involved in HH204_05895 ENOG4108JPW Aminotransferase HH204_05905 ENOG4105CP9 extracellular ligand-binding receptor HH204_05910 ENOG4105U59 -acetyltransferase HH204_05915 ENOG4105CP9 extracellular ligand-binding receptor HH204_05920 ENOG4105C32 Amino acid ABC transporter (Permease) HH204_05925 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HH204_05930 ENOG4105C0Z ABC transporter HH204_05935 ENOG4108IV0 ABC, transporter HH204_05940 ENOG41060M8 Pfam:PhdYeFM HH204_05950 ENOG4105BZ7 extracellular solute-binding protein family 1 HH204_05955 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HH204_05970 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HH204_05975 ENOG4105WC8 Conserved Protein HH204_05980 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HH204_05985 ENOG4105WCN acetyltransferase HH204_05995 ENOG4105D9R oxidoreductase HH204_06000 ENOG4105C2I pirin domain protein HH204_06005 ENOG4105DIQ Transcriptional regulator HH204_06010 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HH204_06015 ENOG4105C6Z Gluconate HH204_06025 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HH204_06030 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HH204_06035 ENOG4108IUM Glycogen debranching enzyme HH204_06040 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HH204_06045 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HH204_06050 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HH204_06055 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HH204_06060 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HH204_06065 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HH204_06070 ENOG4105E98 transcriptional regulator DeoR family HH204_06075 ENOG41061ZR Transcriptional regulator HH204_06080 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HH204_06085 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HH204_06090 ENOG4105C6Z Gluconate HH204_06095 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HH204_06100 ENOG4105MJ2 Competence protein HH204_06105 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HH204_06115 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HH204_06120 ENOG4105CE1 Ferrous iron transport protein b HH204_06125 ENOG4105XFK Ferrous iron transport protein A HH204_06130 ENOG4105BZM domain protein HH204_06135 ENOG4108RRZ Transcription elongation factor GreB HH204_06145 ENOG4105E0F Histidine kinase HH204_06150 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HH204_06160 ENOG4105VEJ Heat shock protein HH204_06165 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HH204_06170 ENOG4105DQY intracellular growth attenuator HH204_06175 ENOG4107RK2 ADP-ribose diphosphatase NudE HH204_06180 ENOG4108JQC penicillin-binding protein 1A HH204_06205 ENOG4105E4G Type IV pilus HH204_06210 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HH204_06215 ENOG4105D49 3-dehydroquinate synthase HH204_06220 ENOG4105EGB membrane protein DamX HH204_06225 ENOG4105DFE Dna adenine methylase HH204_06230 ENOG4105DJV ribulose-phosphate 3-epimerase HH204_06240 ENOG4105C31 Tryptophanyl-tRNA synthetase HH204_06245 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HH204_06250 ENOG4105WZK nitrite reductase NADPH small subunit HH204_06255 ENOG4107QZF nitrite reductase NADPH large subunit HH204_06265 ENOG4105DZC cytosine deaminase HH204_06270 ENOG4106DTQ Protein TsgA homolog HH204_06275 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HH204_06280 ENOG4106195 uncharacterized protein yhfG HH204_06285 ENOG4105MZU cell filamentation protein HH204_06295 ENOG4105C8Y Acetylornithine aminotransferase HH204_06300 ENOG410613R integral membrane protein, YccS YhfK family HH204_06305 ENOG4107RYR Transcriptional regulator, Crp Fnr family HH204_06310 ENOG4108UKZ OsmC family HH204_06315 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HH204_06320 ENOG4105YP7 UPF0270 protein HH204_06325 ENOG4105DNZ Alpha Beta Hydrolase HH204_06335 ENOG4105C5H ABC transporter HH204_06340 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HH204_06345 ENOG4105CKD glutathione-regulated potassium-efflux system protein HH204_06350 ENOG4105VKU nucleicacid-binding protein HH204_06355 ENOG4108YZY peptidylprolyl cis-trans isomerase HH204_06360 ENOG4105VRX Protein slyX homolog HH204_06365 ENOG4108V1T peptidylprolyl cis-trans isomerase HH204_06370 ENOG4105WWK YheO domain protein HH204_06380 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HH204_06385 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HH204_06390 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HH204_06395 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HH204_06400 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HH204_06405 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HH204_06410 ENOG4105W53 bacterioferritin-associated ferredoxin HH204_06415 ENOG4108UQY Iron-storage protein HH204_06430 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HH204_06435 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HH204_06445 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HH204_06450 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HH204_06455 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HH204_06460 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HH204_06465 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HH204_06470 ENOG41083MP 50s ribosomal protein l29 HH204_06475 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HH204_06480 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HH204_06485 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HH204_06500 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HH204_06505 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HH204_06515 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HH204_06520 ENOG4105VPB 50S ribosomal protein L30 HH204_06525 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HH204_06530 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HH204_06535 ENOG41067V7 50S ribosomal protein L36 HH204_06540 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HH204_06545 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HH204_06550 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HH204_06555 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HH204_06560 ENOG4108ZT0 50S ribosomal protein l17 HH204_06565 ENOG4105VTS DnaJ-like, subfamily C HH204_06570 ENOG4105W1Y Transcriptional regulator HH204_06575 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HH204_06580 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HH204_06585 ENOG4105C1A potassium transporter peripheral membrane HH204_06590 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HH204_06595 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HH204_06600 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HH204_06605 ENOG4105C79 DNA protecting protein DprA HH204_06615 ENOG4108WI1 Dna topoisomerase HH204_06620 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HH204_06625 ENOG4105E2X shikimate dehydrogenase HH204_06630 ENOG4105SG3 Protein of unknown function (DUF1488) HH204_06635 ENOG4108Z0R Transferase HH204_06665 ENOG4105XCM membrane LIPOPROTEIN HH204_06675 ENOG4105C1P efflux transporter, rnd family, mfp subunit HH204_06680 ENOG4108XG4 DNA-binding transcriptional regulator HH204_06690 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HH204_06695 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HH204_06705 ENOG4105RG0 Membrane HH204_06710 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HH204_06715 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HH204_06725 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HH204_06740 ENOG41062P1 Diguanylate cyclase phosphodiesterase HH204_06750 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HH204_06755 ENOG4105VQ7 Rod shape-determining protein MreD HH204_06760 ENOG4108Z03 MAF-like protein HH204_06765 ENOG4105C03 ribonuclease HH204_06770 ENOG4105QD6 exported protein HH204_06775 ENOG4105D1U peptidase U62 modulator of DNA gyrase HH204_06780 ENOG4105CR8 Transcriptional regulator HH204_06795 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HH204_06800 ENOG4105UNR (Barnase) inhibitor HH204_06805 ENOG4105RID UPF0379 protein yhcN HH204_06810 ENOG4105RID UPF0379 protein yhcN HH204_06815 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HH204_06820 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HH204_06825 ENOG4105C0H protease HH204_06830 ENOG4105C0H protease HH204_06835 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HH204_06840 ENOG4105D6Z AFG1 family ATPase HH204_06845 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HH204_06860 ENOG4107MKT Stringent starvation protein a HH204_06865 ENOG4105KB2 stringent starvation protein b HH204_06870 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HH204_06875 ENOG4105BZ8 glutamate synthase HH204_06885 ENOG4105N5T Radical SAM Protein HH204_06890 ENOG4108I5G Major Facilitator superfamily HH204_06905 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HH204_06910 ENOG4105BZU Histidine kinase HH204_06915 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HH204_06925 ENOG41080Z8 PHOSPHOCARRIER protein HH204_06930 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HH204_06935 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HH204_06940 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HH204_06945 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HH204_06950 ENOG4108IUZ ABC transporter HH204_06955 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HH204_06960 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HH204_06965 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HH204_06970 ENOG4105C2X Arabinose 5-phosphate isomerase HH204_06975 ENOG4105FEU K -dependent Na -Ca exchanger HH204_06980 ENOG4105DHJ ABC, transporter HH204_06985 ENOG4105CY3 ABC transporter, permease HH204_06990 ENOG4107PE3 Mammalian cell entry related domain protein HH204_06995 ENOG4105E3I toluene tolerance HH204_07000 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HH204_07005 ENOG4105VFK BolA family HH204_07010 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HH204_07015 ENOG4105HVQ Regulatory factor of maltose metabolism HH204_07020 ENOG4105EAH synthase HH204_07025 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HH204_07030 ENOG4105K46 50S ribosomal protein l27 HH204_07035 ENOG4105QYV Membrane HH204_07040 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HH204_07045 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HH204_07050 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HH204_07055 ENOG4105HBR Rna-binding protein HH204_07060 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HH204_07065 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HH204_07070 ENOG4105EEI dihydropteroate synthase HH204_07075 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HH204_07080 ENOG4105NTZ Preprotein translocase subunit SecG HH204_07095 ENOG4108UII YfaZ family HH204_07100 ENOG4108PNB DNA-binding transcriptional regulator HH204_07105 ENOG4105CDH Citrulline--aspartate ligase HH204_07120 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HH204_07125 ENOG4105CHV Transcription elongation factor NusA HH204_07130 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HH204_07135 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HH204_07140 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HH204_07145 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HH204_07150 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HH204_07165 ENOG4105C1J atp-dependent rna helicase HH204_07170 ENOG4105CIC tryptophan-specific transport protein HH204_07175 ENOG4105DEN Luciferase family HH204_07195 ENOG4108YYD acetyltransferase HH204_07200 ENOG41082IR Excinuclease ABC C subunit domain protein HH204_07205 ENOG4108ZPB UPF0306 protein HH204_07210 ENOG4107R7Y intracellular protease Pfpi family HH204_07215 ENOG4105K4T epimerase HH204_07220 ENOG4107S21 permease HH204_07225 ENOG4105W4M Transport-associated protein HH204_07230 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HH204_07235 ENOG41082RQ UPF0102 protein HH204_07240 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HH204_07245 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HH204_07250 ENOG4107R3N Filamentation induced by cAMP protein fic HH204_07260 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HH204_07265 ENOG4105DT3 PTS system, galactitol-specific IIc component HH204_07270 ENOG41090UW PTS System HH204_07275 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HH204_07280 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HH204_07285 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HH204_07290 ENOG4105DM4 PTS System HH204_07295 ENOG4105DE4 1-phosphofructokinase HH204_07300 ENOG4105D2N Aldolase HH204_07310 ENOG4105E98 transcriptional regulator DeoR family HH204_07315 ENOG4107UEK pfkb domain protein HH204_07320 ENOG4105CTX dehydratase HH204_07330 ENOG4105DJB Major Facilitator Superfamily HH204_07335 ENOG4105CNV Aldolase HH204_07340 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HH204_07345 ENOG4105BZW Glycerate kinase HH204_07370 ENOG4106D80 Uncharacterized protein YhaL HH204_07375 ENOG4108CNN domain protein HH204_07380 ENOG4105CWB LysR family transcriptional Regulator HH204_07385 ENOG4105KAF membrAne HH204_07390 ENOG4105CHF Glutathione S-transferase HH204_07395 ENOG4108VBZ doxx family HH204_07400 ENOG4105YJD HH204_07405 ENOG41090KG Inner membrane protein YqjE HH204_07410 ENOG4105NE1 Conserved Protein HH204_07415 ENOG4105WAY exported protein HH204_07420 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HH204_07425 ENOG4106W5V Membrane HH204_07430 ENOG4107YCY Transcriptional regulator HH204_07435 ENOG4105DPW Major facilitator superfamily MFS_1 HH204_07445 ENOG4105CTX dehydratase HH204_07450 ENOG4105P66 Membrane HH204_07455 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HH204_07460 ENOG4105DU1 integral membrane protein, terc HH204_07465 ENOG4105EE0 oxidoreductase HH204_07470 ENOG4108VKG metal-dependent hydrolase HH204_07485 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HH204_07490 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH204_07495 ENOG4107RYS Autoinducer-2 (AI-2) kinase HH204_07500 ENOG4105DKT Transcriptional regulator HH204_07505 ENOG4105C2J ABC transporter HH204_07510 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HH204_07515 ENOG4105F5R ABC transporter HH204_07520 ENOG4105D4B ABC, transporter HH204_07525 ENOG41061GT Aldolase HH204_07530 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HH204_07535 ENOG4107WCA isomerase HH204_07540 ENOG4107W6W Conserved Protein HH204_07545 ENOG4105E5D amino acid HH204_07550 ENOG4105E5D amino acid HH204_07555 ENOG4105FK9 beta-D-galactosidase beta subunit HH204_07560 ENOG4105CNT hydrolase family 2 HH204_07565 ENOG4105CQ4 Transcriptional regulator HH204_07570 ENOG4108Y51 tRNA-binding protein HH204_07575 ENOG4105C8Y Acetylornithine aminotransferase HH204_07580 ENOG4105NTW Transcriptional regulator HH204_07590 ENOG4105Q26 Siderophore-interacting protein HH204_07605 ENOG4108UTZ Dihydroxyacetone kinase HH204_07610 ENOG4105CMT Dihydroxyacetone kinase HH204_07640 ENOG4105C0A alcohol dehydrogenase HH204_07655 ENOG4105YCI dehydratase medium subunit HH204_07660 ENOG4108ZFT Dehydratase small subunit HH204_07665 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HH204_07670 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HH204_07675 ENOG4105XXV Acid-resistance protein HH204_07680 ENOG4108YK4 Acid-resistance membrane protein HH204_07685 ENOG4108V08 YfdX protein HH204_07690 ENOG4105BZU Histidine kinase HH204_07695 ENOG4108WQH regulatoR HH204_07715 ENOG4108VCA G U mismatch-specific DNA glycosylase HH204_07720 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HH204_07725 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HH204_07735 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HH204_07745 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HH204_07750 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HH204_07755 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HH204_07760 ENOG4105CQM Urea amidohydrolase subunit alpha HH204_07765 ENOG4105KI2 Urea amidohydrolase subunit beta HH204_07770 ENOG4108YZ9 Urea amidohydrolase subunit gamma HH204_07775 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HH204_07790 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HH204_07800 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HH204_07805 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HH204_07810 ENOG4106MWK domain protein HH204_07815 ENOG4105I7R Adenylate cyclase HH204_07820 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HH204_07825 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HH204_07840 ENOG4105W0Z cytoplasmic protein HH204_07845 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HH204_07855 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HH204_07860 ENOG4106032 Glutathionylspermidine synthase HH204_07865 ENOG4105F1G UPF0441 protein HH204_07875 ENOG41087AY ADP-Ribose pyrophosphatase HH204_07880 ENOG4108SX3 cytoplasmic protein HH204_07885 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HH204_07890 ENOG4105IPS esterase HH204_07895 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HH204_07900 ENOG4105VRH Antibiotic biosynthesis monooxygenase HH204_07905 ENOG4105NF4 modulator of drug activity HH204_07910 ENOG4105DHQ Histidine kinase HH204_07915 ENOG4105XJC Two component transcriptional regulator (Winged helix family HH204_07920 ENOG4105H4F exported protein HH204_07925 ENOG4105F4I Transcriptional regulator HH204_07930 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HH204_07935 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HH204_07940 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HH204_07945 ENOG4105CCT upf0313 protein HH204_07955 ENOG4105CV8 reductase HH204_07960 ENOG4108I6A alcohol dehydrogenase HH204_07965 ENOG4105CF7 AraC family transcriptional regulator HH204_07970 ENOG4108K81 inner membrane protein YghB HH204_07975 ENOG4105C28 cystathionine HH204_07980 ENOG4105CWK Biopolymer transport protein, ExbB HH204_07985 ENOG4108ZZF transport protein (ExbD) HH204_07990 ENOG4105CT4 transporter HH204_07995 ENOG4105E4I Glycoside hydrolase family 28 HH204_08000 ENOG4108TEB UPF0114 protein HH204_08010 ENOG410900S Protein of unknown function (DUF2623) HH204_08015 ENOG4105CYM Glutathione S-transferase HH204_08030 ENOG4106032 Glutathionylspermidine synthase HH204_08035 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HH204_08060 ENOG4105C28 cystathionine HH204_08095 ENOG4108UQV Membrane HH204_08100 ENOG4105CXN decarboxylase HH204_08105 ENOG4105EAA nucleoside HH204_08110 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HH204_08115 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HH204_08120 ENOG4105CEN a g-specific adenine glycosylase HH204_08125 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HH204_08130 ENOG41090ED Protein with unknown function (DUF469) HH204_08135 ENOG4105K33 Periplasmic Protein HH204_08140 ENOG4108HWW ABC transporter HH204_08145 ENOG4105C2J ABC transporter HH204_08155 ENOG4105CSA Coproporphyrinogen iii oxidase HH204_08160 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HH204_08165 ENOG4105VZ9 UPF0235 protein HH204_08170 ENOG4108VIA integral membrane protein HH204_08175 ENOG4105DFA alanine racemase domain protein HH204_08180 ENOG4105CZX twitching motility protein HH204_08190 ENOG41086KC Transcriptional regulator HH204_08195 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HH204_08200 ENOG4108UJU UPF0301 protein HH204_08205 ENOG4105D7Z glutathione synthase HH204_08210 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HH204_08215 ENOG4105RWS endonuclease I HH204_08220 ENOG4105GPY SprT protein HH204_08225 ENOG4107QNK )-transporter HH204_08230 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HH204_08250 ENOG4105CYW agmatinase HH204_08275 ENOG4105CHR reductase HH204_08280 ENOG4108FUF Transcriptional regulator, IclR family HH204_08290 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HH204_08310 ENOG4105CHR reductase HH204_08315 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) HH204_08330 ENOG4105J5J Outer membrane porin HH204_08335 ENOG4108K0D peptidase, M48 HH204_08340 ENOG4105CV1 Transketolase (EC 2.2.1.1) HH204_08345 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HH204_08355 ENOG4105D2N Aldolase HH204_08360 ENOG4105D64 Mechanosensitive ion channel HH204_08365 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HH204_08370 ENOG4105MPN Membrane HH204_08375 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HH204_08380 ENOG4105E66 phosphoriboisomerase A HH204_08390 ENOG4108JQ1 Dehydrogenase HH204_08395 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HH204_08405 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HH204_08410 ENOG4105E07 UPF0149 protein HH204_08415 ENOG4107RAQ aminopeptidase HH204_08420 ENOG4105D0A hydroxylase HH204_08425 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HH204_08430 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HH204_08435 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HH204_08440 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HH204_08445 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HH204_08450 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HH204_08470 ENOG4105CS2 ec 3.2.1.21 HH204_08475 ENOG4108Q3X Transcriptional regulator HH204_08480 ENOG4105N5Z UPF0267 protein HH204_08485 ENOG4108UT2 hemolysin iii HH204_08495 ENOG4105Y75 tpr repeat protein HH204_08500 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HH204_08505 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HH204_08510 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HH204_08515 ENOG4105T95 Thiol disulfide interChange protein HH204_08520 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HH204_08530 ENOG4105CRK lysyL-tRNA synthetase HH204_08535 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HH204_08545 ENOG4108K5P (LipO)protein HH204_08555 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HH204_08580 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH204_08595 ENOG4105CPC Aldo Keto reductase HH204_08600 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HH204_08610 ENOG4105W7K Transcriptional regulator HH204_08635 ENOG4107R5R arsenical pump membrane protein HH204_08640 ENOG4105K89 arsenate reductase HH204_08645 ENOG4105DUX Transporter HH204_08650 ENOG4105V2F Uncharacterized protein yoac HH204_08655 ENOG4105ETP RND efflux system, outer membrane lipoprotein HH204_08660 ENOG4108MI0 Resistance protein HH204_08665 ENOG4105J12 Multidrug resistance protein mdtN HH204_08675 ENOG4105VR1 Pfam:DUF1271 HH204_08680 ENOG410830R acetyltransferase HH204_08690 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HH204_08695 ENOG4108T65 Fimbrial HH204_08700 ENOG4108SQA Fimbrial HH204_08705 ENOG4105CW0 outer membrane usher protein HH204_08710 ENOG4108NAE Fimbrial chaperone protein HH204_08715 ENOG4108S54 Fimbrial protein HH204_08720 ENOG4108RQP Major type 1 subunit fimbrin HH204_08730 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HH204_08735 ENOG4108W9T type 1 fimbriae regulatory protein HH204_08740 ENOG4105D7X high-affinity nickel-transporter HH204_08745 ENOG4108ZT1 Transcriptional regulator HH204_08750 ENOG4108KTG Membrane protein, drug metabolite transporter HH204_08760 ENOG4108T1W Fimbrial subunit type 3 HH204_08800 ENOG4107S5I aldo keto reductase HH204_08805 ENOG4108MHD transport protein HH204_08820 ENOG4105CHU acetyl-coa acetyltransferase HH204_08825 ENOG4108QGT oligogalacturonate-specific porin HH204_08830 ENOG4105CAZ oligogalacturonide lyase HH204_08845 ENOG4107QNK )-transporter HH204_08850 ENOG4106NDP Transcriptional regulator HH204_08860 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HH204_08865 ENOG4108HKT sucrose-6-phosphate hydrolase HH204_08880 ENOG4108IJ9 (ABC) transporter HH204_08885 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HH204_08890 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HH204_08895 ENOG4105YKW HH204_08915 ENOG4105DDV Transcriptional regulator (LacI family HH204_08920 ENOG4105CK1 PTS System HH204_08925 ENOG4105CS2 ec 3.2.1.21 HH204_08930 ENOG4105C6F GntR Family Transcriptional Regulator HH204_08940 ENOG41060NJ transcriptional regulator HH204_08945 ENOG4105CEY Amp-dependent synthetase and ligase HH204_08950 ENOG4107S74 Lysophospholipid transporter LplT HH204_08955 ENOG4105CPC Aldo Keto reductase HH204_08960 ENOG4105SUV lipoprotein YgdR HH204_08965 ENOG4105EE5 Membrane protein terC HH204_08970 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) HH204_08980 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HH204_08985 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HH204_08990 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HH204_08995 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HH204_09000 ENOG4105IPU prepilin peptidase dependent protein A HH204_09005 ENOG4105JCS prepilin peptidase dependent protein HH204_09010 ENOG4105SEN Protein of unknown function (DUF2509) HH204_09015 ENOG4105RVB Prepilin peptidase dependent protein c HH204_09020 ENOG4105DSY exodeoxyribonuclease V, gamma HH204_09025 ENOG4107QXK peptidase HH204_09035 ENOG4107QYX exodeoxyribonuclease v alpha HH204_09045 ENOG4107QZM n-acetylglutamate synthase HH204_09050 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HH204_09055 ENOG4107QZB decarboxylase HH204_09060 ENOG4105JZC GHMP kinase HH204_09065 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HH204_09070 ENOG4105KTW ethanolamine utilization protein HH204_09075 ENOG4105M3W utilization protein HH204_09085 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HH204_09090 ENOG4105C0A alcohol dehydrogenase HH204_09095 ENOG4108EKI Dehydrogenase HH204_09105 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HH204_09120 ENOG4105KNY Microcompartments protein HH204_09125 ENOG4105KNY Microcompartments protein HH204_09135 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HH204_09140 ENOG4108ZFT Dehydratase small subunit HH204_09145 ENOG4105YCI dehydratase medium subunit HH204_09150 ENOG4105DMB glycerol dehydratase HH204_09155 ENOG4105EHR propanediol utilization protein pduB HH204_09160 ENOG4105KNY Microcompartments protein HH204_09165 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HH204_09170 ENOG4107XVH Transcriptional regulator HH204_09175 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HH204_09180 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HH204_09185 ENOG41081F0 Precorrin-8x methylmutase HH204_09190 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HH204_09195 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HH204_09200 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HH204_09205 ENOG4105CIA precorrin-4 C(11)-methyltransferase HH204_09210 ENOG4108P62 biosynthesis protein (CbiG) HH204_09215 ENOG4105E4R Precorrin-3B C17-methyltransferase HH204_09220 ENOG4105QUC reductase HH204_09225 ENOG4107PPM cobalt chelatase HH204_09230 ENOG4105DVK Precorrin-2 c20-methyltransferase HH204_09235 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HH204_09240 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HH204_09255 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HH204_09260 ENOG4108YZT Adenosylcobinamide kinase HH204_09285 ENOG4105CA3 membrane-bound lytic murein transglycosylase HH204_09290 ENOG4105CUZ uba thif-type nad fad binding protein HH204_09295 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HH204_09300 ENOG4105C9B Cysteine desulfurase HH204_09305 ENOG4105M5B (LipO)protein HH204_09310 ENOG4105ETT transcriptional Regulator, LysR family HH204_09315 ENOG4105M08 Membrane HH204_09325 ENOG4107EDW L-fucose operon activator HH204_09330 ENOG4105NWF RbsD or FucU transport HH204_09335 ENOG4105CMG Carbohydrate kinase HH204_09340 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HH204_09345 ENOG4105EDR glucose galactose transporter HH204_09355 ENOG4107W7X Aldolase HH204_09360 ENOG4105C0A alcohol dehydrogenase HH204_09365 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease HH204_09370 ENOG4108JU7 Transcriptional regulator HH204_09380 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HH204_09395 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HH204_09400 ENOG4108UMI ABC transporter, permease HH204_09405 ENOG4105D01 (LipO)protein HH204_09410 ENOG41079KZ Major Facilitator Superfamily HH204_09420 ENOG4105GVF (ABC) transporter HH204_09425 ENOG4105EJQ L-serine dehydratase HH204_09430 ENOG4105C44 Serine transporter HH204_09435 ENOG4105EWT decarboxylase family HH204_09440 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HH204_09445 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HH204_09450 ENOG4105WP7 tRNA pseudouridine synthase C HH204_09455 ENOG4105DR9 pseudouridine synthase HH204_09460 ENOG4105QDK Flavodoxin HH204_09465 ENOG4105DJB Major Facilitator Superfamily HH204_09470 ENOG4105EQX glucarate dehydratase HH204_09475 ENOG4105EQX glucarate dehydratase HH204_09480 ENOG4105BZW Glycerate kinase HH204_09485 ENOG4105BZU Histidine kinase HH204_09490 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HH204_09495 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HH204_09500 ENOG4105DXN mazG family HH204_09505 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HH204_09510 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HH204_09525 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HH204_09530 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HH204_09535 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HH204_09540 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HH204_09545 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HH204_09550 ENOG4108MXK alkaline phosphatase isozyme conversion HH204_09555 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HH204_09560 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HH204_09570 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HH204_09575 ENOG4105N0Z inner membrane protein ygbE HH204_09580 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HH204_09585 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HH204_09590 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HH204_09595 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HH204_09605 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HH204_09610 ENOG4108K5P (LipO)protein HH204_09615 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HH204_09640 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HH204_09645 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HH204_09650 ENOG4105KZM cytoplasmic protein HH204_09660 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HH204_09720 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HH204_09725 ENOG4105EHG Permease protein HH204_09730 ENOG4107R4I Periplasmic binding protein HH204_09735 ENOG4106QJH hemin transport protein HH204_09755 ENOG4108N2Y auxin Efflux HH204_09765 ENOG4105VXR cytoplasmic protein HH204_09770 ENOG4105CC5 ABC transporter HH204_09775 ENOG4105CC5 ABC transporter HH204_09780 ENOG4105DIK (ABC) transporter HH204_09790 ENOG4105DDV Transcriptional regulator (LacI family HH204_09795 ENOG4105DKQ ROK family HH204_09800 ENOG4105VCP PTS System HH204_09810 ENOG4105VZJ PTS System HH204_09815 ENOG4105CK1 PTS System HH204_09830 ENOG4105CS2 ec 3.2.1.21 HH204_09840 ENOG4105C45 hydrogenase expression formation protein (HypE) HH204_09845 ENOG4105CQS hydrogenase expression formation protein HypD HH204_09850 ENOG41083WG hydrogenase assembly chaperone HH204_09855 ENOG4107RSS Hydrogenase accessory protein HypB HH204_09860 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HH204_09865 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HH204_09870 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HH204_09875 ENOG4107R30 NADH dehydrogenase HH204_09880 ENOG4107TDF Formate hydrogenlyase subunit 4 HH204_09885 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HH204_09890 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HH204_09895 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HH204_09900 ENOG4105I6X formate hydrogenlyase maturation HH204_09905 ENOG4108MG9 hydrogenase 3 maturation protease HH204_09915 ENOG4105CS2 ec 3.2.1.21 HH204_09920 ENOG4105C5Y PTS System HH204_09930 ENOG4105DDV Transcriptional regulator (LacI family HH204_09935 ENOG4108RC0 Electron transport protein HH204_09940 ENOG4105C8H hydrogenase maturation protein Hypf HH204_09950 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HH204_09955 ENOG4105CNW domain protein HH204_09965 ENOG4108JUA Transcriptional regulator HH204_09975 ENOG410804X Transcriptional regulator HH204_09980 ENOG4105J92 DNA-binding transcriptional activator GutM HH204_09985 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HH204_09990 ENOG4105VI0 Pts system, glucitol sorbitol-specific HH204_09995 ENOG4105DZY Pts system, glucitol sorbitol-specific HH204_10000 ENOG410787A Pts system, glucitol sorbitol-specific HH204_10005 ENOG4105CVE Lytic murein transglycosylase HH204_10015 ENOG4105CC5 ABC transporter HH204_10020 ENOG4105DSE periplasmic solute binding protein HH204_10025 ENOG4107TH8 cina domain protein HH204_10030 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HH204_10035 ENOG4105Y3E Modulates RecA activity (By similarity) HH204_10040 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HH204_10045 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HH204_10080 ENOG4105K3G Periplasmic Protein HH204_10085 ENOG4107VXZ Hydrolase HH204_10090 ENOG4105W39 Membrane HH204_10095 ENOG4105D9M gamma-glutamylcysteine synthetase HH204_10110 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HH204_10115 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH204_10120 ENOG4105CW7 secretion protein, HlyD family HH204_10130 ENOG4105NTK Transcriptional repressor Mpra HH204_10140 ENOG4105ZED uncharacterized protein ygaH HH204_10145 ENOG4108UMN azlc family HH204_10150 ENOG4105GIJ Glycine betaine HH204_10155 ENOG4108HQS Glycine betaine HH204_10160 ENOG4108IJ7 Glycine betaine HH204_10165 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HH204_10170 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HH204_10175 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HH204_10180 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HH204_10185 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HH204_10190 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HH204_10195 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HH204_10200 ENOG4108WMJ Protein of unknown function (DUF2002) HH204_10205 ENOG4108RNS Exports L-alanine (By similarity) HH204_10215 ENOG4108X73 DNA- binding protein HH204_10230 ENOG4108V62 Rhodanese domain protein HH204_10235 ENOG41080HT Transcriptional regulator, arsr family HH204_10245 ENOG4105CC0 LysR family Transcriptional regulator HH204_10250 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HH204_10255 ENOG4105C26 Dehydrogenase HH204_10260 ENOG4105X0I Fimbrial HH204_10265 ENOG4108VCD Chaperone HH204_10270 ENOG4105CW0 outer membrane usher protein HH204_10285 ENOG4105CW0 outer membrane usher protein HH204_10290 ENOG4106P2F Pfam:Pili_assembly_C HH204_10295 ENOG4106EAR Fimbrial protein HH204_10300 ENOG4108WQH regulatoR HH204_10315 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HH204_10320 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HH204_10325 ENOG4105MP9 class II Aldolase HH204_10330 ENOG4105CDA abc transporter atp-binding protein HH204_10335 ENOG4106TNF Periplasmic binding protein HH204_10350 ENOG4105CYW agmatinase HH204_10355 ENOG4105EVZ LysR family transcriptional regulator HH204_10370 ENOG4105C1P efflux transporter, rnd family, mfp subunit HH204_10375 ENOG4105UEI Transcriptional Regulator AraC Family HH204_10400 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HH204_10405 ENOG4108Z1B Cyclase dehydrase HH204_10415 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HH204_10425 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HH204_10430 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HH204_10435 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HH204_10440 ENOG4108JU6 CBS domain protein HH204_10445 ENOG4106KVJ cytochrome C assembly protein HH204_10450 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HH204_10455 ENOG4105K5M 30s ribosomal protein S16 HH204_10460 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HH204_10465 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HH204_10470 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HH204_10490 ENOG41090EK ompa motb domain protein HH204_10495 ENOG4108KHX Diguanylate cyclase HH204_10500 ENOG4108WS1 HH204_10505 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HH204_10510 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HH204_10520 ENOG4105CQC Prephenate dehydratase HH204_10530 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HH204_10535 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HH204_10540 ENOG4105C34 Pseudouridine synthase HH204_10545 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HH204_10550 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH204_10575 ENOG4105CSH Transporter HH204_10580 ENOG4105T42 (LipO)protein HH204_10585 ENOG4105JIM Phosphatidylserine synthase HH204_10590 ENOG4105CD5 CoA-binding domain protein HH204_10595 ENOG4106IUH DTW domain containing protein HH204_10600 ENOG4105K63 Thioredoxin HH204_10605 ENOG4105EIB trna rrna methyltransferase HH204_10610 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HH204_10615 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HH204_10620 ENOG4105C1J atp-dependent rna helicase HH204_10625 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HH204_10630 ENOG4108IYU L-aspartate oxidase HH204_10645 ENOG41069PW sigma-e factor negative regulatory protein HH204_10650 ENOG4105VQK sigma E regulatory protein, MucB RseB HH204_10655 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HH204_10660 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HH204_10665 ENOG4105C3F Signal peptidase i HH204_10670 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HH204_10675 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HH204_10680 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HH204_10685 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HH204_10690 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HH204_10695 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HH204_10700 ENOG4106G6Q Transcriptional regulator HH204_10705 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HH204_10710 ENOG4108Z6B deaminase HH204_10715 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HH204_10720 ENOG4108ETH Formylglycinamide ribotide synthetase HH204_10725 ENOG4107WP9 Histidine kinase HH204_10735 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HH204_10740 ENOG4108YZA Nitrogen regulatory protein pii HH204_10745 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HH204_10750 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HH204_10755 ENOG4108SB3 DoxX Family HH204_10760 ENOG4108NZE NAGC-like transcriptional regulator HH204_10765 ENOG4107HQ7 repeat protein HH204_10770 ENOG4107QNK )-transporter HH204_10775 ENOG4108ZKT aldose 1-epimerase HH204_10780 ENOG4105D8G Major Facilitator superfamily HH204_10785 ENOG4108MN2 Stationary phase inducible protein CsiE HH204_10790 ENOG41065CD Exported protein HH204_10795 ENOG4105D7X high-affinity nickel-transporter HH204_10805 ENOG4105ECY inositol monophosphatase HH204_10810 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HH204_10815 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HH204_10820 ENOG4105C3J Cysteine desulfurase HH204_10825 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HH204_10830 ENOG4108Z4V iron-sulfur cluster assembly HH204_10835 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HH204_10840 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HH204_10845 ENOG4108ZIT Ferredoxin, 2FE-2S HH204_10850 ENOG4105WVQ Fe-S assembly protein IscX HH204_10855 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HH204_10860 ENOG4105YYA enhanced serine sensitivity protein SseB HH204_10870 ENOG4105KHC sulfurtransferase HH204_10875 ENOG4105DN3 alpha-2-macroglobulin domain protein HH204_10880 ENOG4108JQB penicillin-binding protein 1C HH204_10885 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HH204_10890 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HH204_10895 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HH204_10900 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HH204_10910 ENOG4105N21 Membrane HH204_10915 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HH204_10920 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HH204_10930 ENOG4105VPD cellular component movement HH204_10935 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HH204_10940 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HH204_10945 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HH204_10955 ENOG4105C4X radical SAM domain protein HH204_10970 ENOG41062G3 Protein of unknown function (DUF2633) HH204_10975 ENOG4105BZU Histidine kinase HH204_10980 ENOG4105C9X ppx gppa phosphatase HH204_10985 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HH204_10990 ENOG4108V3E phosphoribosylglycinamide formyltransferase HH204_10995 ENOG4105CXB phosphoribosylaminoimidazole synthetase HH204_11000 ENOG41066F8 ROK family HH204_11005 ENOG4105CS2 ec 3.2.1.21 HH204_11010 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HH204_11015 ENOG4105C2W permease HH204_11020 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HH204_11030 ENOG4105K89 arsenate reductase HH204_11035 ENOG4105ERG peptidase m48, ste24p HH204_11045 ENOG4105C02 permease HH204_11050 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HH204_11055 ENOG4105RH4 Glycine cleavage system transcriptional repressor HH204_11060 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HH204_11065 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HH204_11070 ENOG4105C8V SAICAR synthetase HH204_11075 ENOG4105CGZ zinc metallopeptidase HH204_11080 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HH204_11085 ENOG4106KED esterase YpfH HH204_11090 ENOG4105XYK UPF0370 protein HH204_11095 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HH204_11100 ENOG4105KUZ arsenate reductase HH204_11110 ENOG4105BZS acriflavin resistance protein HH204_11115 ENOG4105BZ8 glutamate synthase HH204_11120 ENOG4107VIJ nudix hydrolase HH204_11125 ENOG4108PVD exported protein HH204_11130 ENOG4105CV1 Transketolase (EC 2.2.1.1) HH204_11135 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HH204_11140 ENOG4105C6K Malic enzyme HH204_11145 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HH204_11150 ENOG4106S4J ethanolamine utilization protein EutP HH204_11155 ENOG4105NDK ethanolamine utilization protein HH204_11160 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HH204_11165 ENOG4108IJ2 phosphate acetyltransferase HH204_11170 ENOG4105KNY Microcompartments protein HH204_11175 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HH204_11180 ENOG4108EKI Dehydrogenase HH204_11185 ENOG4107YMV ethanolamine utilization protein HH204_11190 ENOG4105C0A alcohol dehydrogenase HH204_11195 ENOG4105ENY Ethanolamine utilization protein eutH HH204_11200 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HH204_11215 ENOG4106D67 ethanolamine utilization protein HH204_11220 ENOG4108X49 Ethanolamine utilization protein EutK HH204_11225 ENOG4108K3Z AraC family transcriptional regulator HH204_11230 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HH204_11235 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HH204_11240 ENOG4108R6G acetyltransferase HH204_11245 ENOG4105QZU Inner membrane protein YfeZ HH204_11250 ENOG4105E7K (LipO)protein HH204_11255 ENOG4105EZR dyp-type peroxidase family protein HH204_11265 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HH204_11270 ENOG4108I5D sulfate abc transporter HH204_11275 ENOG4105ECW sulfate abc transporter HH204_11290 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HH204_11295 ENOG4105CSW GntR family transcriptional regulator HH204_11310 ENOG4105C5Y PTS System HH204_11315 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HH204_11320 ENOG4105KZ7 phosphocarrier protein hpr HH204_11330 ENOG4105C6T cysteine synthase HH204_11335 ENOG4105EXN Sulfate transport protein CysZ HH204_11340 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HH204_11350 ENOG4105VRT cytoplasmic protein HH204_11355 ENOG4105DHU Bile acid HH204_11360 ENOG4108M0I Transcriptional regulator HH204_11385 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HH204_11390 ENOG4105GXM Putative transcription regulator (DUF1323) HH204_11395 ENOG4105HZG regulatoR HH204_11410 ENOG4108KMM Diguanylate cyclase HH204_11415 ENOG4105D9N nucleoside HH204_11420 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HH204_11430 ENOG4105CPC Aldo Keto reductase HH204_11435 ENOG4107RA9 decarboxylase HH204_11445 ENOG4105CHC glucokinase (EC 2.7.1.2) HH204_11450 ENOG4105DY9 regulatoR HH204_11455 ENOG4108HRK Histidine kinase HH204_11470 ENOG4105CHM Aminotransferase HH204_11480 ENOG4105DJ2 Major Facilitator Superfamily HH204_11485 ENOG4107Y2X deaminase HH204_11490 ENOG4105DND Transcriptional regulator HH204_11510 ENOG4105S64 Formate nitrite transporter HH204_11515 ENOG410903C (LipO)protein HH204_11520 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HH204_11525 ENOG4105KZW UPF0381 protein HH204_11535 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HH204_11540 ENOG4108BY2 phosphohistidine phosphatase HH204_11545 ENOG4108DG9 Smr protein MutS2 HH204_11550 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HH204_11555 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HH204_11560 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HH204_11565 ENOG4105EJ9 Membrane HH204_11570 ENOG4108BPE -transporting atpase HH204_11575 ENOG4105MH2 YfcL protein HH204_11580 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HH204_11585 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HH204_11590 ENOG4105F9N Major Facilitator Superfamily HH204_11595 ENOG4106WZ1 flagella biosynthesis regulator HH204_11605 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HH204_11610 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HH204_11615 ENOG4105DQR SNARE associated Golgi HH204_11625 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HH204_11630 ENOG4108S3P Sporulation domain protein HH204_11635 ENOG4105E96 Colicin v production protein HH204_11640 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HH204_11645 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HH204_11655 ENOG4105E89 ABC transporter HH204_11660 ENOG4105E89 ABC transporter HH204_11665 ENOG4105DSP amino acid AbC transporter HH204_11670 ENOG4106YG3 ABC transporter HH204_11675 ENOG4108JEH abc transporter atp-binding protein HH204_11680 ENOG4105KNA -acetyltransferase HH204_11690 ENOG4105ECP epimerase HH204_11695 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HH204_11700 ENOG4105CYM Glutathione S-transferase HH204_11705 ENOG4108SHQ Glutathione S-transferase HH204_11710 ENOG4108RE9 Phosphodiesterase HH204_11715 ENOG4105PTV Nudix Hydrolase HH204_11720 ENOG4105C6K Malic enzyme HH204_11725 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HH204_11730 ENOG4105PQ6 UPF0208 membrane protein HH204_11740 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HH204_11745 ENOG4107QWE )-transporter HH204_11750 ENOG4105DK2 UPF0207 protein HH204_11755 ENOG4105CHM Aminotransferase HH204_11760 ENOG4107NQ8 LysR family Transcriptional regulator HH204_11770 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HH204_11775 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HH204_11780 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HH204_11785 ENOG4105GKE subunit e HH204_11790 ENOG4107QIZ NADH dehydrogenase HH204_11795 ENOG4108IEH NADH dehydrogenase subunit g HH204_11800 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HH204_11810 ENOG4107UFS subunit j HH204_11815 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HH204_11820 ENOG4105D65 subunit l HH204_11825 ENOG4105C8S subunit m HH204_11830 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HH204_11835 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HH204_11840 ENOG4107YB6 acetyltransferase, (GNAT) family HH204_11845 ENOG4105E4F Isochorismate synthase HH204_11850 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HH204_11855 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HH204_11860 ENOG4108IPT Naphthoate synthase HH204_11865 ENOG4105DNI Converts SHCHC to OSB (By similarity) HH204_11870 ENOG4105CEY Amp-dependent synthetase and ligase HH204_11880 ENOG4105DNE Transposase HH204_11890 ENOG4108UII YfaZ family HH204_11895 ENOG4108EWA cinA-like protein HH204_11900 ENOG4107258 Transcriptional regulator HH204_11905 ENOG4105CXK mandelate racemase muconate lactonizing HH204_11910 ENOG4105CSP Major Facilitator Superfamily HH204_11915 ENOG4105CNV Aldolase HH204_11920 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HH204_11925 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HH204_11930 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HH204_11935 ENOG4105CXY transporter HH204_11940 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HH204_11945 ENOG4105XPH Ferredoxin HH204_11950 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HH204_11955 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HH204_11960 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HH204_11965 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HH204_11970 ENOG4105BZU Histidine kinase HH204_11975 ENOG41068CG regulatoR HH204_11980 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HH204_11995 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HH204_12000 ENOG4105CF1 Alkylated DNA repair protein HH204_12005 ENOG4105IBP Cyclic peptide transporter HH204_12010 ENOG4105CJW magnesium transporter HH204_12015 ENOG4105CHH sulfate transporter HH204_12030 ENOG4105F4G Membrane HH204_12070 ENOG4108R7K Metal Dependent Phosphohydrolase HH204_12075 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HH204_12080 ENOG4105H40 HH204_12105 ENOG4108S1U HH204_12115 ENOG4105CAR Terminase, large subunit HH204_12135 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HH204_12150 ENOG4108MXB Protein of unknown function (DUF968) HH204_12155 ENOG4105HGD Antitermination protein HH204_12180 ENOG4105NVB glycoside hydrolase, family 19 HH204_12230 ENOG4105CAR Terminase, large subunit HH204_12290 ENOG41064PC HH204_12325 ENOG4105BZU Histidine kinase HH204_12330 ENOG4105BZU Histidine kinase HH204_12350 ENOG4105KT5 UmuD protein HH204_12355 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HH204_12385 ENOG4105E68 Sulfatase HH204_12390 ENOG4105PAN UPF0352 protein HH204_12395 ENOG4106V8H Nucleoid-associated protein HH204_12400 ENOG4105N2W Transcriptional regulator HH204_12405 ENOG4107VIJ nudix hydrolase HH204_12420 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HH204_12425 ENOG4105CFI type iii restriction protein res subunit HH204_12430 ENOG4105I08 Pseudouridine synthase HH204_12435 ENOG4105C2C drug resistance transporter, Bcr CflA HH204_12440 ENOG4105HG6 HH204_12445 ENOG4108JQ5 ABC transporter HH204_12450 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HH204_12455 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HH204_12460 ENOG4105E43 Extracellular solute-binding protein, family 5 HH204_12465 ENOG4105CXC rtn protein HH204_12470 ENOG4107TT5 NLP P60 protein HH204_12475 ENOG41076MN Phosphoesterase, PA-phosphatase related HH204_12480 ENOG4105CKI cobalamin synthesis protein HH204_12485 ENOG4105DEI Mannitol dehydrogenase HH204_12490 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HH204_12500 ENOG4105KRS Proteinase inhibitor HH204_12505 ENOG4105S8Q sugar efflux transporter HH204_12510 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HH204_12515 ENOG4105DE4 1-phosphofructokinase HH204_12525 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HH204_12530 ENOG4105HMI Membrane HH204_12535 ENOG4105DUM transcriptional regulator, lysR family HH204_12540 ENOG4108IQI permease HH204_12550 ENOG4105D05 Receptor HH204_12560 ENOG4105EUJ GTP cyclohydrolase i HH204_12565 ENOG4105DHF Membrane HH204_12570 ENOG41060NJ transcriptional regulator HH204_12580 ENOG4105C2J ABC transporter HH204_12585 ENOG4107SDZ Galactoside transport system permease protein mglC HH204_12590 ENOG4107GZ4 SanA protein HH204_12595 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HH204_12600 ENOG41067MG lrgb family HH204_12605 ENOG4105VAW lrga family HH204_12610 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HH204_12615 ENOG4105TW1 Carbohydrate-selective porin OprB HH204_12630 ENOG4105CS2 ec 3.2.1.21 HH204_12640 ENOG4105KHU inner membrane protein YohD HH204_12645 ENOG41069YE inner membrane protein yohC HH204_12650 ENOG41061WM D-Alanyl-D-Alanine HH204_12665 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HH204_12670 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HH204_12675 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HH204_12680 ENOG4108IJ8 ABC transporter HH204_12685 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HH204_12695 ENOG4108HRK Histidine kinase HH204_12700 ENOG4108NEV two component transcriptional regulator, LytTR family HH204_12705 ENOG4108W15 Protein of unknown function (DUF1456) HH204_12710 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HH204_12715 ENOG4105D1F ATP-binding protein HH204_12725 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HH204_12735 ENOG4105C7N Xanthine uracil vitamin C permease HH204_12740 ENOG4105CPN adenine deaminase HH204_12745 ENOG4105DUM transcriptional regulator, lysR family HH204_12760 ENOG4105DWF phosphomethylpyrimidine kinase HH204_12765 ENOG4105EIE fructose-bisphosphate aldolase HH204_12770 ENOG4105IE8 Alpha-ketoglutarate permease HH204_12795 ENOG4105DEI Mannitol dehydrogenase HH204_12800 ENOG4105CMG Carbohydrate kinase HH204_12805 ENOG4105IE8 Alpha-ketoglutarate permease HH204_12810 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HH204_12815 ENOG4105CXK mandelate racemase muconate lactonizing HH204_12820 ENOG4105DEF Extracellular solute-binding protein, family 5 HH204_12825 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HH204_12830 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HH204_12840 ENOG4108JQ7 (ABC) transporter HH204_12850 ENOG4105CFP Peptidase U32 HH204_12855 ENOG4105E3W Two component transcriptional regulator (Winged helix family HH204_12865 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH204_12870 ENOG4105BZS acriflavin resistance protein HH204_12875 ENOG4105BZS acriflavin resistance protein HH204_12880 ENOG4105ENT Efflux transporter rnd family, mfp subunit HH204_12885 ENOG4105CK2 sodium dicarboxylate symporter HH204_12905 ENOG4105BZU Histidine kinase HH204_12910 ENOG4105R8A Heat shock protein HH204_12915 ENOG4105D03 DNA-3-methyladenine glycosylase II HH204_12920 ENOG4105DBI uridine monophosphokinase HH204_12925 ENOG4105DHP deoxycytidine triphosphate deaminase HH204_12930 ENOG4108GAE asmA family HH204_12935 ENOG4105EE5 Membrane protein terC HH204_12940 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HH204_12945 ENOG4105MH5 phosphoesterase PA-phosphatase related protein HH204_12955 ENOG4108MRJ HH204_12960 ENOG4105DAY polysaccharide export protein HH204_13000 ENOG4106WTF Glycosyl transferase, family 2 HH204_13005 ENOG4105C0K Gdp-mannose 4,6-dehydratase HH204_13010 ENOG4105C30 Nad-dependent epimerase dehydratase HH204_13015 ENOG4105FGF GDP-mannose mannosyl hydrolase HH204_13020 ENOG4106CD9 glycosyl transferase group 1 HH204_13030 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HH204_13095 ENOG4105CPK Glycosyl transferase (Group 1 HH204_13105 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HH204_13110 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HH204_13115 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HH204_13120 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HH204_13125 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HH204_13130 ENOG4105CIH Imidazole acetol-phosphate transaminase HH204_13140 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HH204_13150 ENOG4107SRH Nad-dependent epimerase dehydratase HH204_13155 ENOG4105EQ1 Transcriptional regulator HH204_13165 ENOG4105CUB amino acid HH204_13170 ENOG4105YVS arsR family transcriptional regulator HH204_13175 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HH204_13180 ENOG4105CJB Exodeoxyribonuclease I HH204_13185 ENOG4105DZ1 carboxypeptidase HH204_13195 ENOG4105DR8 Membrane HH204_13200 ENOG41090HJ UPF0265 protein HH204_13205 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HH204_13210 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HH204_13215 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HH204_13225 ENOG41090U3 tautomerase HH204_13230 ENOG4105HEI LysR family (Transcriptional regulator HH204_13240 ENOG4105CSH Transporter HH204_13250 ENOG4105BZU Histidine kinase HH204_13255 ENOG4108YS1 cytoplasmic protein HH204_13260 ENOG4105YP6 Domain of unknown function (DUF1869) HH204_13265 ENOG4105ETT transcriptional Regulator, LysR family HH204_13280 ENOG4105BZU Histidine kinase HH204_13310 ENOG4105DVF Cytosine-specific methyltransferase HH204_13410 ENOG4106D0Q Type IV secretion system protein VirB2 HH204_13425 ENOG4105KF5 hemolysin expression-modulating protein HH204_13455 ENOG4107ZSV Receptor HH204_13460 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HH204_13480 ENOG4105C0W non-ribosomal peptide synthetase HH204_13495 ENOG4105BZ1 (ABC) transporter HH204_13500 ENOG4105EYM Major Facilitator superfamily HH204_13525 ENOG4105UQX Mate efflux family protein HH204_13535 ENOG4105FYV Amp nucleosidase HH204_13555 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HH204_13560 ENOG4108WUH Transcriptional regulator, TetR family HH204_13565 ENOG4105EEQ Na H antiporter HH204_13585 ENOG4105CMM transposase HH204_13665 ENOG4108EHY type IV secretion system HH204_13740 ENOG4105ETT transcriptional Regulator, LysR family HH204_13745 ENOG4105F8D glycoside hydrolase family 4 HH204_13755 ENOG4108NKV transcriptional regulator HH204_13760 ENOG4108V1U phospholipid-binding protein HH204_13765 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH204_13775 ENOG4105CHR reductase HH204_13795 ENOG4105C87 Aminotransferase class I and II HH204_13800 ENOG4105DC8 reductase HH204_13805 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HH204_13825 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HH204_13830 ENOG4105DT3 PTS system, galactitol-specific IIc component HH204_13835 ENOG4105DJV ribulose-phosphate 3-epimerase HH204_13845 ENOG41080HJ 6-phospho 3-hexuloisomerase HH204_13855 ENOG4105C2J ABC transporter HH204_13860 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HH204_13865 ENOG4105CNN ABC, transporter HH204_13890 ENOG4107R11 Transcriptional regulator HH204_13910 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HH204_13920 ENOG4105FCK Membrane HH204_13930 ENOG4105Y0K Inner membrane protein YedR HH204_13935 ENOG4105EST Metal Dependent Phosphohydrolase HH204_13940 ENOG4105DVF Cytosine-specific methyltransferase HH204_13945 ENOG41090BB DNA mismatch endonuclease (vsr) HH204_13950 ENOG4105FDR Membrane HH204_13955 ENOG4105CKW Inner membrane protein yedI HH204_13965 ENOG4105YX3 cellular response to acidity HH204_13980 ENOG4105JCU Inherit from NOG: (Lipo)protein HH204_13985 ENOG4105E5K Alpha-amylase HH204_13990 ENOG4105EAB amino acid AbC transporter HH204_13995 ENOG4105K6H D-cysteine desulfhydrase HH204_14000 ENOG4105E5Q amino acid AbC transporter HH204_14005 ENOG4105CDA abc transporter atp-binding protein HH204_14010 ENOG4105VJY transcriptional regulator HH204_14015 ENOG4105XVG cytoplasmic protein HH204_14020 ENOG4105WH1 Two component transcriptional regulator luxr family HH204_14055 ENOG4106RHG Yeca family HH204_14065 ENOG4105VVZ metal-binding protein HH204_14070 ENOG41090A1 ferritin HH204_14085 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH204_14090 ENOG4105N4N Protein of unknown function (DUF2766) HH204_14105 ENOG4108UEC Ferritin-like protein HH204_14120 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HH204_14130 ENOG4105CNN ABC, transporter HH204_14140 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HH204_14145 ENOG4108VA4 Universal stress protein HH204_14155 ENOG4105F5H Glycosyl Hydrolase Family 88 HH204_14160 ENOG4105C75 arginyL-tRNA synthetase HH204_14165 ENOG4106ZCM YecM protein HH204_14170 ENOG4106N3A copper homeostasis protein cutc HH204_14180 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HH204_14185 ENOG4105WJG Glutathione HH204_14190 ENOG41081XQ Conserved Protein HH204_14195 ENOG4105D3W isochorismatase HH204_14200 ENOG4105C9M aspartyl-trna synthetase HH204_14205 ENOG4108TIT dATP pyrophosphohydrolase HH204_14210 ENOG4105CDY transcriptional regulatory protein HH204_14215 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HH204_14220 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HH204_14225 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HH204_14230 ENOG4105FAV ABC, transporter HH204_14240 ENOG4105NXV High-affinity zinc uptake system protein HH204_14245 ENOG4105DR5 peptidase HH204_14250 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HH204_14255 ENOG4105CA9 Pyruvate kinase HH204_14260 ENOG4106KNT transcriptional regulator HH204_14270 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HH204_14275 ENOG4105C01 Dihydroxy-acid dehydratase HH204_14290 ENOG4105X2V dna damage-inducible protein HH204_14295 ENOG4108Q2J Inner membrane protein YebE HH204_14300 ENOG4105CUG Oligopeptidase b HH204_14305 ENOG4105UMD exodeoxyribonuclease X HH204_14310 ENOG4105MPK DNA polymerase III subunit theta HH204_14315 ENOG4105FXM Copper resistance protein HH204_14320 ENOG4108PNC copper resistance HH204_14325 ENOG4105NKT exported protein HH204_14335 ENOG4108MJ5 VirK protein HH204_14340 ENOG4108R1E Serine threonine protein phosphatase 1 HH204_14345 ENOG4105UVW uncharacterized protein yebW HH204_14350 ENOG4105WT8 Protein of unknown function (DUF1480) HH204_14355 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HH204_14360 ENOG4105DY2 Paraquat-inducible protein b HH204_14365 ENOG4105H2K paraquat-inducible protein a HH204_14370 ENOG4108ZGC gaf domain protein HH204_14375 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HH204_14380 ENOG4105CN1 protease HH204_14385 ENOG4105D0M Protease HtpX homolog HH204_14390 ENOG4105C0R drug resistance transporter emrb qaca subfamily HH204_14395 ENOG4105J4Q Transcriptional regulator HH204_14400 ENOG4105TIK HH204_14410 ENOG4105Q3Y exported protein HH204_14430 ENOG4105CJN penicillin-binding protein HH204_14435 ENOG4105DHI Methyltransferase HH204_14440 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HH204_14445 ENOG4108NK4 UPF0266 membrane protein HH204_14450 ENOG4105F3R pts system mannose fructose sorbose family iid HH204_14455 ENOG4105ETZ PTS System HH204_14460 ENOG4105DAS pts system HH204_14465 ENOG4105EE5 Membrane protein terC HH204_14470 ENOG4107XTP (EAL) domain protein HH204_14480 ENOG4105EJQ L-serine dehydratase HH204_14485 ENOG4105P8F nudix hydrolase HH204_14495 ENOG4105X5C UPF0181 protein HH204_14500 ENOG4105M4H endoribonuclease L-psp HH204_14505 ENOG4105DVT helicase HH204_14510 ENOG41072GX Peptidase M22 Glycoprotease HH204_14515 ENOG4105Y4Z Outer Membrane Lipoprotein HH204_14520 ENOG4105CEY Amp-dependent synthetase and ligase HH204_14525 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HH204_14530 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HH204_14535 ENOG4107QMS site-determining protein HH204_14540 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HH204_14545 ENOG4105VNG YcgL domain-containing protein HH204_14550 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HH204_14555 ENOG4108ZZ3 UPF0260 protein HH204_14565 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HH204_14570 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HH204_14575 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) HH204_14580 ENOG4105ED1 spovr family HH204_14590 ENOG4105MWK D-amino acid dehydrogenase, small subunit HH204_14600 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HH204_14605 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HH204_14610 ENOG4106JQ5 Transglycosylase SLT domain HH204_14615 ENOG4105E0K tonB-dependent siderophore receptor HH204_14670 ENOG410811B TRANSCRIPTIONal HH204_14675 ENOG4105C7B Threonine dehydratase HH204_14690 ENOG4105C6N Formate acetyltransferase HH204_14705 ENOG4105C32 Amino acid ABC transporter (Permease) HH204_14710 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HH204_14715 ENOG4105C0Z ABC transporter HH204_14720 ENOG4108IV0 ABC, transporter HH204_14725 ENOG4107YNJ LysR family Transcriptional regulator HH204_14745 ENOG4105CSH Transporter HH204_14755 ENOG4105F04 LysR family Transcriptional regulator HH204_14765 ENOG4105D3G Pseudouridine synthase HH204_14770 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HH204_14795 ENOG4108ZG0 Ompa motb domain protein HH204_14805 ENOG4105CS6 Rhs element vgr protein HH204_14895 ENOG4105C3G gtp-binding protein HH204_14900 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HH204_14905 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HH204_14915 ENOG4105CHH sulfate transporter HH204_14920 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HH204_14925 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HH204_14935 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HH204_14940 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HH204_14945 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HH204_14950 ENOG4108YY7 Invasion gene expression up-regulator SirB HH204_14955 ENOG41063JG Transcriptional regulator HH204_14960 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HH204_14965 ENOG4105EWV Sodium calcium exchanger membrane region HH204_14970 ENOG4105WS7 Cation transport regulator HH204_14975 ENOG4108NH8 Cation transport protein HH204_14985 ENOG41090EX DsrE family HH204_15000 ENOG4105I5W Transporter HH204_15010 ENOG4105D7T ABC transporter HH204_15015 ENOG4107QZF nitrite reductase NADPH large subunit HH204_15025 ENOG4105ID0 Putative invasin HH204_15030 ENOG4105WH1 Two component transcriptional regulator luxr family HH204_15035 ENOG4105BZU Histidine kinase HH204_15040 ENOG4105DQQ Major facilitator superfamily MFS_1 HH204_15050 ENOG4105CRU nitrate reductase, alpha subunit HH204_15055 ENOG4108IUE nitrate reductase beta subunit HH204_15060 ENOG4105R3A Nitrate reductase HH204_15065 ENOG41076YT nitrate reductase, gamma subunit HH204_15115 ENOG4105CIY formyltetrahydrofolate deformylase HH204_15125 ENOG4105D78 K07001 NTE family protein HH204_15130 ENOG4105I93 response regulator HH204_15135 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HH204_15150 ENOG4107104 thymidine kinase HH204_15155 ENOG4105C0A alcohol dehydrogenase HH204_15165 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HH204_15175 ENOG4108J59 Extracellular solute-binding protein, family 5 HH204_15180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HH204_15185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HH204_15190 ENOG4105C3U ABC transporter HH204_15195 ENOG4108JQ7 (ABC) transporter HH204_15200 ENOG4105EYW Ion transport protein HH204_15205 ENOG4108W5H UPF0263 protein HH204_15210 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HH204_15225 ENOG4108YYC ycei family HH204_15235 ENOG4105K9H YciI-like protein HH204_15240 ENOG410822N TonB family HH204_15250 ENOG4105P10 Uncharacterized protein ydiZ HH204_15255 ENOG4105DE4 1-phosphofructokinase HH204_15260 ENOG4108NE3 Salt-induced outer membrane protein HH204_15275 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HH204_15280 ENOG41082NX 50s ribosomal protein l35 HH204_15295 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HH204_15300 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HH204_15305 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HH204_15320 ENOG4105RQF LysR family Transcriptional regulator HH204_15330 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) HH204_15335 ENOG4105D01 (LipO)protein HH204_15340 ENOG4108V06 Glutathione peroxidase HH204_15350 ENOG4108QBX (LipO)protein HH204_15355 ENOG4105CNG UPF0061 protein HH204_15365 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HH204_15380 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HH204_15395 ENOG4105IPI Membrane HH204_15400 ENOG4105CQB FAD linked oxidase domain protein HH204_15405 ENOG4105KA0 thioesterase Superfamily protein HH204_15410 ENOG4105Y3U Transglycosylase-associated protein HH204_15425 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HH204_15435 ENOG4105E0A ABC, transporter HH204_15440 ENOG4105EHG Permease protein HH204_15450 ENOG4106KR7 LysR family Transcriptional regulator HH204_15475 ENOG4105DMF Dehydrogenase HH204_15480 ENOG4105KBX Transcriptional regulator, TetR family HH204_15500 ENOG4108Z4V iron-sulfur cluster assembly HH204_15505 ENOG4105DIW FeS assembly protein SUFB HH204_15510 ENOG4105C3K feS assembly ATPase SufC HH204_15515 ENOG4105JRK feS assembly protein SufD HH204_15520 ENOG4105C9B Cysteine desulfurase HH204_15525 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HH204_15530 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HH204_15540 ENOG4105CA9 Pyruvate kinase HH204_15555 ENOG4105RFR Protein of unknown function (DUF2767) HH204_15570 ENOG4105DJB Major Facilitator Superfamily HH204_15575 ENOG4105E2X shikimate dehydrogenase HH204_15580 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein HH204_15585 ENOG4108W0P ABC transporter HH204_15590 ENOG4105EHG Permease protein HH204_15595 ENOG4105S10 periplasmic binding protein HH204_15600 ENOG4108K2P TRANSCRIPTIONal HH204_15605 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HH204_15615 ENOG4107UB2 Alpha beta hydrolase fold HH204_15620 ENOG4105IKQ hydratase HH204_15635 ENOG4108SC4 )-transporter HH204_15650 ENOG4108T2C cysteine dioxygenase type I HH204_15655 ENOG4106KR7 LysR family Transcriptional regulator HH204_15660 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HH204_15680 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HH204_15685 ENOG4108IY8 ABC, transporter HH204_15695 ENOG4105E0A ABC, transporter HH204_15700 ENOG4105DQ5 transport system permease protein HH204_15720 ENOG4106PMH Extracellular solute-binding protein family 3 HH204_15725 ENOG4105E5Q amino acid AbC transporter HH204_15730 ENOG4105CDA abc transporter atp-binding protein HH204_15770 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HH204_15775 ENOG4105DG4 malate L-lactate dehydrogenase HH204_15785 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HH204_15790 ENOG4107Z33 ABC transporter, permease HH204_15825 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HH204_15830 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HH204_15835 ENOG41060IM Heme exporter protein HH204_15845 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HH204_15850 ENOG4105DA4 cytochrome c-type biogenesis protein HH204_15855 ENOG4107QX9 Thiol disulfide interChange protein HH204_15860 ENOG4105KWW Biogenesis protein HH204_15885 ENOG4105CHR reductase HH204_15890 ENOG4105C7K acetolactate synthase HH204_15905 ENOG4105DTD Dehydrogenase HH204_15910 ENOG4105CY2 Citrate transporter HH204_15915 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HH204_15920 ENOG4105CHU acetyl-coa acetyltransferase HH204_15925 ENOG4107QNJ CoA-transferase subunit B HH204_15935 ENOG4106NZI LysR family Transcriptional regulator HH204_15960 ENOG4105CQB FAD linked oxidase domain protein HH204_15965 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HH204_15985 ENOG4105KME endoribonuclease L-psp HH204_15990 ENOG4107TTD cytosine deaminase HH204_16000 ENOG4105EMY transcriptional regulator HH204_16040 ENOG4105CXC rtn protein HH204_16055 ENOG4105EB3 Histidine kinase HH204_16060 ENOG4105ENT Efflux transporter rnd family, mfp subunit HH204_16065 ENOG4105BZS acriflavin resistance protein HH204_16105 ENOG4108JQ7 (ABC) transporter HH204_16110 ENOG4105C3U ABC transporter HH204_16135 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HH204_16140 ENOG4105E98 transcriptional regulator DeoR family HH204_16150 ENOG4107B2H carbonic anhydrase HH204_16220 ENOG4108URH decarboxylase HH204_16230 ENOG4107QI1 Mate efflux family protein HH204_16235 ENOG4108R6K riboflavin synthase, subunit alpha HH204_16240 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HH204_16245 ENOG4105CZQ inner membrane transport protein YdhC HH204_16250 ENOG4105F52 Transcriptional regulator HH204_16255 ENOG4105ETE Transcriptional regulator (LacI family HH204_16265 ENOG4105F27 Major Facilitator HH204_16270 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HH204_16280 ENOG4105K4H Nlp p60 protein HH204_16285 ENOG4105M2J Glutaredoxin HH204_16290 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HH204_16295 ENOG4108UYE Lactoylglutathione lyase HH204_16300 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH204_16305 ENOG4108WUH Transcriptional regulator, TetR family HH204_16310 ENOG4105XZD Fe-S protein HH204_16315 ENOG4107RGM aldo keto reductase HH204_16320 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HH204_16325 ENOG4105DSW Fusaric acid resistance protein HH204_16330 ENOG4105Y49 secretion protein, HlyD family HH204_16345 ENOG4105BZU Histidine kinase HH204_16350 ENOG4108XTF Outer Membrane Lipoprotein HH204_16355 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HH204_16360 ENOG410642K Lysozyme inhibitor HH204_16365 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HH204_16370 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HH204_16375 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HH204_16380 ENOG4108K3A Glutathione S-transferase HH204_16390 ENOG4105CSM endonuclease III HH204_16400 ENOG4108UQQ Electron transport complex HH204_16425 ENOG4105M9B inner membrane protein ydgK HH204_16435 ENOG4105CS2 ec 3.2.1.21 HH204_16445 ENOG4105D9R oxidoreductase HH204_16450 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HH204_16455 ENOG4105EQ0 Major Facilitator superfamily HH204_16475 ENOG4105CPW cytochrome b561 HH204_16495 ENOG4105DDW LysR family Transcriptional regulator HH204_16500 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HH204_16505 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HH204_16510 ENOG4105E32 cytoplasmic protein HH204_16515 ENOG4105EBR Carboxylesterase HH204_16535 ENOG4107WE3 acetyltransferase YdcK HH204_16540 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HH204_16545 ENOG41088CC tellurite resistance protein tehB HH204_16550 ENOG4108KKZ (LipO)protein HH204_16560 ENOG4105UEI Transcriptional Regulator AraC Family HH204_16570 ENOG4108JCI Transcriptional regulator HH204_16580 ENOG4105CFP Peptidase U32 HH204_16600 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HH204_16605 ENOG4105C4M (Ubiquinol oxidase) subunit I HH204_16615 ENOG4107TYH extracellular solute-binding protein family 1 HH204_16620 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HH204_16625 ENOG4105D81 ABC transporter, permease HH204_16630 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HH204_16635 ENOG4105C26 Dehydrogenase HH204_16660 ENOG410654E Membrane HH204_16665 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HH204_16680 ENOG4105DEF Extracellular solute-binding protein, family 5 HH204_16685 ENOG4105R71 cytoplasmic protein HH204_16690 ENOG4108T9Y Inner membrane protein ydcZ HH204_16695 ENOG4108Z7F N-acetyltransferase HH204_16705 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HH204_16710 ENOG4105DU0 nucleoside hydrolase HH204_16720 ENOG41065TG regulatoR HH204_16725 ENOG4105CI2 imidazolone-5-propionate hydrolase HH204_16730 ENOG4105CHB tonB-dependent Receptor HH204_16735 ENOG4108NS2 receptor HH204_16745 ENOG4105C85 amino acid HH204_16750 ENOG4105EQ2 LysR family Transcriptional regulator HH204_16760 ENOG4105DEN Luciferase family HH204_16775 ENOG4105EAB amino acid AbC transporter HH204_16785 ENOG4105DRP amino acid AbC transporter HH204_16790 ENOG4105CDA abc transporter atp-binding protein HH204_16800 ENOG4108N27 Glutathione S-transferase HH204_16805 ENOG4105KZK Tautomerase pptA HH204_16825 ENOG4105CT4 transporter HH204_16840 ENOG4108MEJ flavin reductase domain protein HH204_16845 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HH204_16850 ENOG4105C4Y ABC transporter HH204_16855 ENOG4107RCV ABC transporter, permease HH204_16860 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HH204_16865 ENOG4105D0D Nitrate reductase 2, gamma subunit HH204_16870 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HH204_16875 ENOG4108IUE nitrate reductase beta subunit HH204_16880 ENOG4105CRU nitrate reductase, alpha subunit HH204_16885 ENOG4107QND Nitrite extrusion protein HH204_16900 ENOG4107HP6 Transcriptional regulator HH204_16905 ENOG4105DTQ mandelate racemase muconate lactonizing HH204_16910 ENOG4105NN7 muconolactone delta-isomerase HH204_16915 ENOG410626B catechol 1,2-dioxygenase HH204_16925 ENOG4108UKV benzoate 1,2-dioxygenase HH204_16950 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HH204_16955 ENOG4108MG3 formate dehydrogenase HH204_16970 ENOG4105CSR polyphosphate kinase 2 HH204_16980 ENOG4105F27 Major Facilitator HH204_16995 ENOG4108JQ6 ABC transporter HH204_17000 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HH204_17015 ENOG4105DQ4 alcohol dehydrogenase HH204_17030 ENOG4105C5H ABC transporter HH204_17040 ENOG4107R1I NAD-dependent malic enzyme HH204_17060 ENOG4105JQN Transcriptional regulator HH204_17065 ENOG4105N0E Protein of unknown function (DUF2543) HH204_17070 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HH204_17085 ENOG4108N8X transition metal ion binding HH204_17095 ENOG4105CG3 alpha amylase, catalytic region HH204_17115 ENOG4108YDI single-species biofilm formation on inanimate substrate HH204_17125 ENOG4108Z9K Osmotically inducible protein HH204_17150 ENOG4105FFC UPF0187 protein HH204_17155 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HH204_17160 ENOG4105C5Q Transcriptional regulator HH204_17165 ENOG4105CK1 PTS System HH204_17190 ENOG4105VZJ PTS System HH204_17195 ENOG4105VCP PTS System HH204_17200 ENOG4108KUU Inner membrane metabolite transport protein ydjE HH204_17205 ENOG4105KT7 mgtC SapB transporter HH204_17210 ENOG4105D6Z AFG1 family ATPase HH204_17215 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HH204_17220 ENOG4106KR7 LysR family Transcriptional regulator HH204_17240 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HH204_17245 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF HH204_17250 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HH204_17260 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) HH204_17265 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HH204_17275 ENOG4108IGT Dipeptidase HH204_17280 ENOG4108J2P Alpha beta hydrolase fold HH204_17290 ENOG4105E0F Histidine kinase HH204_17305 ENOG4105DY8 decarboxylase HH204_17310 ENOG4108JPW Aminotransferase HH204_17315 ENOG4107Z6I Thiamine biosynthesis protein HH204_17320 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HH204_17325 ENOG4108YI8 ABC transporter HH204_17330 ENOG4105ETU transcriptional activator (TenA HH204_17345 ENOG4105CIB oxidoreductase Domain protein HH204_17355 ENOG4105ETE Transcriptional regulator (LacI family HH204_17360 ENOG4105BZU Histidine kinase HH204_17365 ENOG4107QUY Guanine deaminase HH204_17410 ENOG4105CVJ phosphoglycerate mutase HH204_17415 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HH204_17430 ENOG41089BK Glutamine amido-transferase HH204_17435 ENOG4105R1U AraC Family Transcriptional Regulator HH204_17460 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HH204_17485 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HH204_17510 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HH204_17530 ENOG4105E5Q amino acid AbC transporter HH204_17540 ENOG4105C5R Aminotransferase HH204_17555 ENOG4105CBN LysR family transcriptional regulator HH204_17565 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HH204_17570 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HH204_17575 ENOG4105CSH Transporter HH204_17600 ENOG4105FCD Major Facilitator HH204_17610 ENOG4105ETE Transcriptional regulator (LacI family HH204_17615 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HH204_17625 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HH204_17630 ENOG4105UP7 3-epimerase HH204_17640 ENOG4108YRF PTS System HH204_17645 ENOG4105DM4 PTS System HH204_17650 ENOG410829K Lysine exporter protein (Lyse ygga) HH204_17660 ENOG4105CBN LysR family transcriptional regulator HH204_17665 ENOG4105HEI LysR family (Transcriptional regulator HH204_17680 ENOG4107PP3 Acetylornithine deacetylase HH204_17695 ENOG4105CNN ABC, transporter HH204_17700 ENOG4105C2J ABC transporter HH204_17705 ENOG4105ETE Transcriptional regulator (LacI family HH204_17735 ENOG4109066 lysm domain bon superfamily protein HH204_17775 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HH204_17780 ENOG4105E98 transcriptional regulator DeoR family HH204_17790 ENOG4108RVA ribokinase HH204_17795 ENOG4105EDR glucose galactose transporter HH204_17815 ENOG4105CHR reductase HH204_17820 ENOG4105CHU acetyl-coa acetyltransferase HH204_17830 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HH204_17840 ENOG4105BZW Glycerate kinase HH204_17845 ENOG4107VHA regulatoR HH204_17865 ENOG4107YCY Transcriptional regulator HH204_17870 ENOG4105CI1 PTS System HH204_17875 ENOG4105F8D glycoside hydrolase family 4 HH204_17885 ENOG4105C54 Major Facilitator superfamily HH204_17890 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HH204_17910 ENOG4105NIV Esterase HH204_17930 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HH204_17945 ENOG4108VCD Chaperone HH204_17950 ENOG4105CW0 outer membrane usher protein HH204_17960 ENOG4105F32 YngK protein HH204_17965 ENOG4105CAF HipA N-terminal domain protein HH204_17970 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HH204_17975 ENOG4105VT2 5-hydroxyisourate hydrolase HH204_17980 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HH204_17985 ENOG4105C2W permease HH204_17990 ENOG41061H0 Monooxygenase HH204_17995 ENOG4108KSA LysR family transcriptional regulator HH204_18015 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HH204_18030 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HH204_18040 ENOG4105D01 (LipO)protein HH204_18050 ENOG4108UMI ABC transporter, permease HH204_18055 ENOG4105EA8 2-Nitropropane dioxygenase HH204_18065 ENOG4105EGI Transcriptional regulator HH204_18070 ENOG4105CBP Major Facilitator HH204_18080 ENOG4105F9N Major Facilitator Superfamily HH204_18115 ENOG4107QZW Altronate oxidoreductase HH204_18125 ENOG4105BZU Histidine kinase HH204_18135 ENOG4105CSV Glutaminase HH204_18140 ENOG4105C26 Dehydrogenase HH204_18145 ENOG4105EGI Transcriptional regulator HH204_18155 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HH204_18160 ENOG4105MVE transcriptional regulator HH204_18165 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HH204_18170 ENOG4107S2N Type III effector Hrp-dependent HH204_18175 ENOG4105C0A alcohol dehydrogenase HH204_18180 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HH204_18185 ENOG4108JQ1 Dehydrogenase HH204_18195 ENOG4105JAB phenazine biosynthesis protein, phzf family HH204_18200 ENOG4105F27 Major Facilitator HH204_18205 ENOG41082NP Multiple antibiotic resistance HH204_18215 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HH204_18220 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HH204_18225 ENOG4106DNR multiple antibiotic resistance protein HH204_18230 ENOG4108594 Permease of the drug metabolite transporter HH204_18245 ENOG4108IV0 ABC, transporter HH204_18250 ENOG4105C0Z ABC transporter HH204_18255 ENOG4105CNN ABC, transporter HH204_18260 ENOG4105C32 Amino acid ABC transporter (Permease) HH204_18265 ENOG41083Z3 extracellular ligand-binding receptor HH204_18280 ENOG4105ECQ AraC Family Transcriptional Regulator HH204_18300 ENOG4105ETE Transcriptional regulator (LacI family HH204_18305 ENOG4105CNT hydrolase family 2 HH204_18310 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HH204_18315 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HH204_18330 ENOG4105MVE transcriptional regulator HH204_18340 ENOG4105G63 Type III effector Hrp-dependent HH204_18345 ENOG4105FB2 class II Aldolase HH204_18350 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HH204_18355 ENOG4105C6Z Gluconate HH204_18375 ENOG4105BZU Histidine kinase HH204_18380 ENOG4108WTK competence damage-inducible protein HH204_18385 ENOG4108ZNX Heat shock protein HH204_18405 ENOG4108WQH regulatoR HH204_18420 ENOG4108RAV Conserved protein HH204_18425 ENOG4105R1U AraC Family Transcriptional Regulator HH204_18435 ENOG4105DGW oligopeptidase A HH204_18440 ENOG4105EMU Dehydrogenase HH204_18445 ENOG4107XBN GntR Family Transcriptional Regulator HH204_18450 ENOG4108U51 Universal stress protein HH204_18455 ENOG4105DEI Mannitol dehydrogenase HH204_18460 ENOG4108I5G Major Facilitator superfamily HH204_18465 ENOG4105KK4 UPF0060 membrane protein HH204_18470 ENOG4105M5Q UPF0482 protein HH204_18475 ENOG4108MK9 spermidine N(1)-acetyltransferase HH204_18485 ENOG4105KBG Protein of unknown function (DUF1161) HH204_18490 ENOG4107QY8 reductase HH204_18495 ENOG4105QAX Iron-sulfur HH204_18500 ENOG4107KGK dmso reductase anchor subunit HH204_18505 ENOG4108NEM leader-binding protein dmsD HH204_18510 ENOG4105CMQ Chloride channel HH204_18515 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HH204_18520 ENOG4105DAG ROK family HH204_18525 ENOG4106NZI LysR family Transcriptional regulator HH204_18530 ENOG4105D94 Major Facilitator Superfamily HH204_18535 ENOG4105CTD carboxy-peptidase HH204_18555 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HH204_18565 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) HH204_18570 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HH204_18575 ENOG4105DSF transport protein HH204_18605 ENOG4107TT2 Auxin Efflux Carrier HH204_18610 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HH204_18615 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HH204_18620 ENOG4108K70 Transcriptional regulator HH204_18625 ENOG4105DWT malate dehydrogenase (quinone) HH204_18630 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HH204_18640 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HH204_18645 ENOG4108MRH transcriptional regulatory protein HH204_18665 ENOG4107GFK fumarate HH204_18675 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HH204_18680 ENOG4105F2Z 3-oxoadipate enol-lactonase HH204_18685 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HH204_18690 ENOG4105CHU acetyl-coa acetyltransferase HH204_18695 ENOG4107QNJ CoA-transferase subunit B HH204_18710 ENOG4108DG9 Smr protein MutS2 HH204_18715 ENOG4106KR7 LysR family Transcriptional regulator HH204_18725 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HH204_18730 ENOG4105CFC Transporter HH204_18740 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HH204_18745 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HH204_18750 ENOG4105Q9Y Universal stress protein HH204_18755 ENOG410671Z uncharacterized protein ydiH HH204_18760 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HH204_18765 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HH204_18780 ENOG4105C5D exported protein HH204_18785 ENOG4105D5Q Arginine ornithine antiporter HH204_18790 ENOG410642E Short chain dehydrogenase HH204_18795 ENOG4105RA2 Membrane HH204_18800 ENOG4107EXC regulatoR HH204_18810 ENOG4105JJR Histidine kinase HH204_18820 ENOG4105C9Q fumarate hydratase class II HH204_18825 ENOG4107GFK fumarate HH204_18830 ENOG4105EIP mannose-6-phosphate isomerase HH204_18835 ENOG4106J39 exported protein HH204_18840 ENOG4107P2S Transcriptional regulator HH204_18845 ENOG4105CI1 PTS System HH204_18850 ENOG4105C87 Aminotransferase class I and II HH204_18860 ENOG41061EV selenium-binding protein YdfZ HH204_18875 ENOG41066VF YeeE YedE family protein HH204_18885 ENOG41064WM Uncharacterized protein YcgX HH204_18890 ENOG4105VPI YqaE family transport protein HH204_18895 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HH204_18900 ENOG4105C26 Dehydrogenase HH204_18910 ENOG4107DB1 DUF218 domain HH204_18915 ENOG4105CSH Transporter HH204_18925 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HH204_18930 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HH204_18935 ENOG4105C26 Dehydrogenase HH204_18940 ENOG4105F4X arginine HH204_18945 ENOG4105C8Y Acetylornithine aminotransferase HH204_18955 ENOG4105D82 Glutamate dehydrogenase HH204_18960 ENOG4108FN7 Aldo keto reductase HH204_18965 ENOG410642W LysR family Transcriptional regulator HH204_18985 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HH204_18995 ENOG4105CQ7 ATP-dependent helicase HH204_19000 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HH204_19010 ENOG4108Z0R Transferase HH204_19015 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HH204_19020 ENOG4105DZS Phenylacetate-CoA ligase HH204_19025 ENOG4105CHU acetyl-coa acetyltransferase HH204_19030 ENOG4108ZJI phenylacetic acid degradation protein HH204_19040 ENOG4108UKI Enoyl-CoA hydratase HH204_19045 ENOG4105E39 Enoyl-CoA hydratase HH204_19050 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HH204_19055 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HH204_19060 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HH204_19065 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HH204_19070 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HH204_19075 ENOG4105DXM phenylacetic acid degradation protein HH204_19080 ENOG4105F11 amine oxidase HH204_19095 ENOG4105C26 Dehydrogenase HH204_19100 ENOG4108WFR AraC Family Transcriptional Regulator HH204_19105 ENOG4105WXT Conserved Protein HH204_19110 ENOG410689M (LipO)protein HH204_19115 ENOG4107H52 Dicarboxylate transport HH204_19120 ENOG4108KF1 Membrane HH204_19125 ENOG4105C5I Dehydrogenase HH204_19130 ENOG41090X5 Heat shock protein hslJ HH204_19135 ENOG4105IKK cytoplasmic protein HH204_19140 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HH204_19145 ENOG4105FCK Membrane HH204_19155 ENOG4108RW8 Universal stress protein F HH204_19165 ENOG4105C1J atp-dependent rna helicase HH204_19170 ENOG4107RX3 Mg2 transporter protein cora family protein HH204_19175 ENOG4105E98 transcriptional regulator DeoR family HH204_19180 ENOG4105D9R oxidoreductase HH204_19195 ENOG4108UMI ABC transporter, permease HH204_19205 ENOG4105D01 (LipO)protein HH204_19245 ENOG4105HEI LysR family (Transcriptional regulator HH204_19270 ENOG4108XFH Transcriptional regulator HH204_19275 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HH204_19355 ENOG4107X35 defense response to bacterium HH204_19370 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH204_19380 ENOG4108ZG0 Ompa motb domain protein HH204_19410 ENOG4106FE3 DNA repair HH204_19420 ENOG4108C33 Resolvase HH204_19555 ENOG4108TFU terminase (Small subunit) HH204_19595 ENOG4105HGD Antitermination protein HH204_19605 ENOG4105QBX endodeoxyribonuclease RusA HH204_19610 ENOG4105CDU Replicative dna helicase HH204_19615 ENOG4106CVF DNA replication protein HH204_19715 ENOG4105DFP Integrase HH204_19720 ENOG4108Z0Z intracellular protease Pfpi family HH204_19735 ENOG4105CBN LysR family transcriptional regulator HH204_19795 ENOG4105BZU Histidine kinase HH204_19810 ENOG4107RTG Major Facilitator superfamily HH204_19815 ENOG4105ENX hydrolase HH204_19820 ENOG4105EQ2 LysR family Transcriptional regulator HH204_19835 ENOG4107QSI ABC, transporter HH204_19845 ENOG4105KXI murein peptide amidase A HH204_19850 ENOG4107S8C mandelate racemase muconate lactonizing HH204_19855 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HH204_19860 ENOG4108KK1 membrane protein AbrB duplication HH204_19865 ENOG4108JU8 Transcriptional regulator HH204_19870 ENOG4105F8D glycoside hydrolase family 4 HH204_19875 ENOG4105W8I Transcriptional regulator HH204_19880 ENOG4106K28 UPF0283 membrane protein HH204_19885 ENOG4105CM6 amino acid regulated cytosolic protein HH204_19890 ENOG4105NNG Peripheral inner membrane phage-shock protein HH204_19895 ENOG4105FM1 phage shock protein C HH204_19900 ENOG4105YYT phage shock protein B HH204_19905 ENOG41087YS Phage shock protein A HH204_19910 ENOG4105E51 psp operon transcriptional activator HH204_19920 ENOG4105CH2 amidohydrolase HH204_19925 ENOG41063ZK Transcriptional Regulator AraC Family HH204_19940 ENOG4108J59 Extracellular solute-binding protein, family 5 HH204_19945 ENOG4108EKA peptide transport system, permease HH204_19950 ENOG4108EU3 peptide transport system, permease HH204_19955 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HH204_19960 ENOG4108JQ2 peptide transport system atp-binding protein HH204_19965 ENOG4105ETS cytosine purines uracil thiamine allantoin HH204_19975 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HH204_19980 ENOG4105Q4T oxidoreductase HH204_19985 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HH204_19995 ENOG4105N2W Transcriptional regulator HH204_20005 ENOG41061RM osmotically inducible lipoprotein HH204_20010 ENOG4108ZJT translation initiation factor, Sui1 HH204_20020 ENOG4105CFV Tetratricopeptide repeat protein HH204_20025 ENOG4105Q4A inner membrane protein yciS HH204_20030 ENOG4105EYK Phosphatidylglycerophosphatase B HH204_20035 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HH204_20040 ENOG4107QM5 aconitate hydratase HH204_20050 ENOG4107R11 Transcriptional regulator HH204_20055 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HH204_20060 ENOG4105RKX Protein of unknown function (DUF2498) HH204_20065 ENOG4105ERU peptidase HH204_20075 ENOG4105UBK short-chain dehydrogenase reductase HH204_20080 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HH204_20090 ENOG4105ETT transcriptional Regulator, LysR family HH204_20100 ENOG4107RTD sua5 ycio yrdc ywlc family protein HH204_20105 ENOG4105DB7 PHP domain protein HH204_20110 ENOG4105CRQ synthase (Component I) HH204_20115 ENOG4108EFP Anthranilate synthase component II HH204_20120 ENOG4105DK0 Indole-3-glycerol phosphate synthase HH204_20125 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HH204_20130 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HH204_20175 ENOG4108IU3 tonb-dependent siderophore receptor HH204_20180 ENOG4107E2E PKHD-type hydroxylase HH204_20185 ENOG4105EIF outer membrane protein W HH204_20190 ENOG4105PI0 Ferredoxin HH204_20195 ENOG4108S3I UPF0259 membrane protein HH204_20200 ENOG4107835 probably involved in intracellular septation (By similarity) HH204_20210 ENOG4105NAU thioesterase Superfamily protein HH204_20215 ENOG4107PN8 YfeABCD locus regulator HH204_20220 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HH204_20225 ENOG4105CHR reductase HH204_20230 ENOG4107K5X Membrane-bound metal-dependent hydrolase HH204_20235 ENOG4108ETY sodium dicarboxylate symporter HH204_20240 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HH204_20250 ENOG410901P UPF0249 protein HH204_20255 ENOG4105F8D glycoside hydrolase family 4 HH204_20260 ENOG4105EZV Transcriptional regulator HH204_20265 ENOG4105VCP PTS System HH204_20270 ENOG4105CK1 PTS System HH204_20280 ENOG4105VZJ PTS System HH204_20285 ENOG4105KKI DNA-binding transcriptional activator OsmE HH204_20295 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HH204_20300 ENOG4108SPG Periplasmic Protein HH204_20310 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HH204_20315 ENOG4105C26 Dehydrogenase HH204_20320 ENOG4105F4X arginine HH204_20330 ENOG4105CGK Exodeoxyribonuclease III HH204_20335 ENOG4108RSN SNARE associated Golgi HH204_20340 ENOG4108N5C SNARE associated Golgi protein-related protein HH204_20345 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HH204_20350 ENOG4105VNH ABC transporter solute-binding protein HH204_20355 ENOG4105CXZ ABC transporter, permease HH204_20360 ENOG4108VGW abc transporter atp-binding protein HH204_20370 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HH204_20375 ENOG4105M6F mutator MutT protein HH204_20380 ENOG4105D82 Glutamate dehydrogenase HH204_20390 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HH204_20395 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HH204_20400 ENOG4105SBG acid phosphatase HH204_20405 ENOG41069NU Nitroreductase HH204_20410 ENOG4105D07 Signal peptide peptidase, SppA HH204_20415 ENOG4105HDK L-asparaginase HH204_20420 ENOG4108RWI nicotinamidase HH204_20430 ENOG4105N1F Hnh endonuclease HH204_20435 ENOG4105VUT cytoplasmic protein HH204_20440 ENOG4105E0X reductase HH204_20445 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HH204_20450 ENOG4105DSB aldose 1-epimerase HH204_20455 ENOG4105CV8 reductase HH204_20460 ENOG4105GNX MltA-interacting MipA family protein HH204_20465 ENOG4105CYN Serine protein kinase HH204_20470 ENOG4106AKX UPF0229 protein HH204_20480 ENOG4108V06 Glutathione peroxidase HH204_20505 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HH204_20510 ENOG4105CBN LysR family transcriptional regulator HH204_20515 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HH204_20520 ENOG4105KT5 UmuD protein HH204_20525 ENOG4105Y50 Virulence Protein HH204_20530 ENOG4108XNZ glycosyl transferase HH204_20535 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HH204_20540 ENOG4108VMM UPF0756 membrane protein HH204_20545 ENOG4105R1U AraC Family Transcriptional Regulator HH204_20550 ENOG4105DJ2 Major Facilitator Superfamily HH204_20555 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HH204_20560 ENOG4105EWC Purine nucleoside phosphorylase HH204_20565 ENOG4105K78 MarR family Transcriptional regulator HH204_20570 ENOG4105UCG Domain of unknown function (DUF333) HH204_20575 ENOG410620I Diguanylate cyclase HH204_20580 ENOG4106G4W HH204_20595 ENOG4105S5I Membrane HH204_20600 ENOG4108NIW Leucine export protein LeuE HH204_20605 ENOG4105D1S lipid A biosynthesis HH204_20620 ENOG4105DHT Metal Dependent Phosphohydrolase HH204_20625 ENOG4106TD9 Diguanylate cyclase HH204_20630 ENOG4107RSM transcriptional regulator HH204_20665 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HH204_20670 ENOG4105C4M (Ubiquinol oxidase) subunit I HH204_20675 ENOG4105WEF catalase HH204_20680 ENOG4108N8X transition metal ion binding HH204_20685 ENOG4108Z9Z response to DNA damage stimulus HH204_20700 ENOG4105E2A Dehydrogenase HH204_20705 ENOG4105XDF Protein of unknown function (DUF1272) HH204_20725 ENOG4108ZHR arsR family transcriptional regulator HH204_20730 ENOG4108HMX isocitrate dehydrogenase (NADP) HH204_20745 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HH204_20750 ENOG41075W9 High frequency lysogenization protein HflD homolog HH204_20755 ENOG4107QTF adenylosuccinate lyase HH204_20775 ENOG4105IFJ Histidine kinase HH204_20780 ENOG4105EZE Cupin 4 family protein HH204_20785 ENOG4108UK5 Transposase HH204_20805 ENOG4105D38 putrescine abc transporter HH204_20810 ENOG4108HM4 ABC transporter HH204_20830 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HH204_20835 ENOG4108YZG isomerase HH204_20840 ENOG4105VI0 Pts system, glucitol sorbitol-specific HH204_20845 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HH204_20850 ENOG4105G63 Type III effector Hrp-dependent HH204_20865 ENOG4105DKT Transcriptional regulator HH204_20875 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HH204_20880 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HH204_20885 ENOG4105D60 lipoprotein releasing system transmembrane protein HH204_20890 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HH204_20895 ENOG4105D60 lipoprotein releasing system transmembrane protein HH204_20910 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HH204_20915 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HH204_20925 ENOG4108IND Tetr family transcriptional regulator HH204_20940 ENOG4107MBR 17 kDa surface antigen HH204_20945 ENOG4105CEP NADH dehydrogenase HH204_20950 ENOG4105D0Y UPF0227 protein HH204_20965 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HH204_20970 ENOG41090DQ Lipoprotein HH204_20975 ENOG4105K59 histidine triad (HIT) protein HH204_20980 ENOG4105CI1 PTS System HH204_20985 ENOG4105F8V Hydrolase, tatD family HH204_20990 ENOG4107QRG dna polymerase iii HH204_20995 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HH204_21000 ENOG4105HHA aminodeoxychorismate lyase HH204_21005 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HH204_21010 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HH204_21015 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HH204_21020 ENOG4105CHR reductase HH204_21025 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HH204_21030 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HH204_21035 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HH204_21040 ENOG4105VGS 50s ribosomal protein l32 HH204_21045 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HH204_21050 ENOG4108UHJ MAF-like protein HH204_21055 ENOG4105EI2 Pseudouridine synthase HH204_21065 ENOG4107QQB Ribonuclease E HH204_21070 ENOG4105CR8 Transcriptional regulator HH204_21075 ENOG4105EQ0 Major Facilitator superfamily HH204_21080 ENOG4105CJR Integral membrane protein (MviN HH204_21085 ENOG4105EP9 oxidoreductase HH204_21090 ENOG4108YXG UPF0502 protein HH204_21095 ENOG4105D9U N-acetyltransferase HH204_21100 ENOG4105EV4 Multidrug resistance protein mdtH HH204_21105 ENOG4105F3T (LipO)protein HH204_21110 ENOG4105EKE dihydroorotase HH204_21115 ENOG4105MEA DNA damage-inducible protein i HH204_21120 ENOG4105PVA Biofilm formation regulatory protein BssS HH204_21130 ENOG4106974 biofilm formation HH204_21145 ENOG4105D1S lipid A biosynthesis HH204_21155 ENOG4108W47 Acidic protein msyB HH204_21160 ENOG4105NAC (LipO)protein HH204_21165 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HH204_21175 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HH204_21190 ENOG4108UQ5 membrane protein YcdZ HH204_21195 ENOG4107XHZ cytoplasmic chaperone TorD family protein HH204_21205 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HH204_21220 ENOG4105HEI LysR family (Transcriptional regulator HH204_21225 ENOG4105EUB pirin domain protein HH204_21230 ENOG4105CHJ isochorismatase hydrolase HH204_21240 ENOG4105D5M phosphate starvation-inducible protein HH204_21245 ENOG4105DBE peroxidase HH204_21250 ENOG410650H (LipO)protein HH204_21260 ENOG4105D9N nucleoside HH204_21275 ENOG4105CK7 Sodium proline symporter HH204_21280 ENOG4105C26 Dehydrogenase HH204_21290 ENOG4108R86 Transcriptional regulator HH204_21295 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HH204_21305 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) HH204_21310 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HH204_21315 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HH204_21320 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HH204_21325 ENOG4105C2W permease HH204_21335 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HH204_21350 ENOG4105XH3 HH204_21355 ENOG4105D6F Phosphatase HH204_21365 ENOG4105CHR reductase HH204_21380 ENOG4105CUB amino acid HH204_21385 ENOG4105CFQ glutamine synthetase HH204_21390 ENOG4108Z86 Glutamine amidotransferase HH204_21395 ENOG4107VRI Transcriptional regulator HH204_21400 ENOG4105C26 Dehydrogenase HH204_21405 ENOG4105CJP fad dependent oxidoreductase HH204_21410 ENOG4105EJC lysr family transcriptional regulator HH204_21415 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HH204_21420 ENOG4105C94 Transporter HH204_21425 ENOG4105DVW rieske (2Fe-2S) HH204_21430 ENOG4105C26 Dehydrogenase HH204_21435 ENOG4105E3J oxidoreductase HH204_21440 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HH204_21445 ENOG4105DM4 PTS System HH204_21450 ENOG4108YRF PTS System HH204_21460 ENOG4108AHH pyruvate formate lyase II activase HH204_21465 ENOG4108XCZ PTS System HH204_21475 ENOG4106R3P AraC family transcriptional regulator HH204_21480 ENOG4105BZU Histidine kinase HH204_21500 ENOG4105BZU Histidine kinase HH204_21505 ENOG41082AN stage II sporulation protein HH204_21520 ENOG4107QSI ABC, transporter HH204_21525 ENOG4108MN8 Membrane HH204_21535 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HH204_21540 ENOG4108UQN AraC family transcriptional regulator HH204_21545 ENOG4108V1U phospholipid-binding protein HH204_21550 ENOG4105DR4 Methyltransferase HH204_21555 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HH204_21560 ENOG4105K4P CoA-binding domain protein HH204_21570 ENOG41088T4 Helicase IV HH204_21575 ENOG410901E Membrane HH204_21580 ENOG4105EM2 membrane HH204_21585 ENOG4108RZ1 DNA transformation protein HH204_21590 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) HH204_21595 ENOG4105UYK outer membrane protein a HH204_21600 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HH204_21605 ENOG4105DAN ATP-dependent protease HH204_21610 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) HH204_21615 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HH204_21620 ENOG4108Q2G (LipO)protein HH204_21625 ENOG4105DY2 Paraquat-inducible protein b HH204_21630 ENOG4105F1S paraquat-inducible protein a HH204_21635 ENOG4105C5H ABC transporter HH204_21640 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HH204_21645 ENOG4105QVC MOSC domain-containing protein HH204_21650 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HH204_21660 ENOG4108UZX fmn reductase HH204_21665 ENOG4105GVF (ABC) transporter HH204_21670 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HH204_21675 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HH204_21685 ENOG4105CD8 aminopeptidase N HH204_21690 ENOG4107RH7 Nicotinate phosphoribosyltransferase HH204_21695 ENOG4105CH2 amidohydrolase HH204_21705 ENOG4105C44 Serine transporter HH204_21710 ENOG4107RCH Diaminopropionate ammonia-lyase HH204_21720 ENOG4105C5S asparaginyl-tRNA synthetase HH204_21725 ENOG4105ZIT Porin Gram-negative type HH204_21730 ENOG4105CGF Aromatic amino acid aminotransferase HH204_21735 ENOG4105C5X domain protein HH204_21740 ENOG4105EAQ (twin-arginine translocation) pathway signal HH204_21745 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HH204_21750 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HH204_21755 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HH204_21760 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HH204_21765 ENOG4106371 Methyltransferase HH204_21770 ENOG4107S90 membrAne HH204_21775 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HH204_21780 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HH204_21785 ENOG4105W49 UPF0434 protein HH204_21790 ENOG4105T0Z Conserved Protein HH204_21795 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HH204_21800 ENOG4105BZ1 (ABC) transporter HH204_21805 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HH204_21810 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HH204_21815 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HH204_21820 ENOG4105CAT Cytidine monophosphate kinase HH204_21825 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HH204_21830 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HH204_21835 ENOG4107VMU Membrane HH204_21840 ENOG4105DDY UPF0142 protein ycaO HH204_21845 ENOG4105TMB Formate nitrite transporter HH204_21850 ENOG4105C6N Formate acetyltransferase HH204_21855 ENOG4105F1A Pyruvate formate-lyase HH204_21860 ENOG4108ISG Major Facilitator HH204_21870 ENOG4107KGK dmso reductase anchor subunit HH204_21875 ENOG4105QAX Iron-sulfur HH204_21880 ENOG4107QY8 reductase HH204_21885 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HH204_21890 ENOG4105D1H recombination factor protein RarA HH204_21895 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HH204_21900 ENOG4105CNU cell division protein FtsK HH204_21905 ENOG4105EW9 transcriptional regulator AsnC family HH204_21915 ENOG4105C3M thioredoxin reductase HH204_21920 ENOG4108JJ9 ABC, transporter HH204_21925 ENOG4108JJ8 (ABC) transporter HH204_21930 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HH204_21935 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HH204_21940 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HH204_21945 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HH204_21950 ENOG4105VEQ Cold shock protein HH204_21960 ENOG4105DJY efflux transporter, rnd family, mfp subunit HH204_21965 ENOG4105CPB ATP-dependent endonuclease of the OLD family HH204_21970 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HH204_21975 ENOG4105DWU Membrane HH204_21985 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HH204_21995 ENOG4105C7K acetolactate synthase HH204_22000 ENOG4105C5W Aldolase HH204_22005 ENOG4105CGD Nad-dependent epimerase dehydratase HH204_22010 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HH204_22015 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HH204_22025 ENOG41064MM (LipO)protein HH204_22030 ENOG4105E5Z arginine transporter ATP-binding subunit HH204_22035 ENOG4106PMH Extracellular solute-binding protein family 3 HH204_22040 ENOG4105GBT ABC transporter HH204_22045 ENOG4105DMR ABC, transporter HH204_22050 ENOG4106TNF Periplasmic binding protein HH204_22055 ENOG4105BZU Histidine kinase HH204_22060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HH204_22065 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HH204_22070 ENOG4105RBQ inner membrane protein ybjO HH204_22075 ENOG4105D38 putrescine abc transporter HH204_22080 ENOG4105F38 ABC transporter, permease HH204_22085 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HH204_22090 ENOG4107RUE extracellular solute-binding protein family 1 HH204_22095 ENOG4108RMJ sensory transduction regulator HH204_22105 ENOG4108DBC nitroreductase HH204_22110 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HH204_22115 ENOG41090BQ Glutaredoxin HH204_22120 ENOG4105GWF inner membrane protein YbjM HH204_22125 ENOG4105D0C transport protein HH204_22150 ENOG4108RFG Tetr family transcriptional regulator HH204_22155 ENOG4106UW1 Major Facilitator superfamily HH204_22160 ENOG4108HCJ Hydrolase HH204_22165 ENOG4107QF7 multi-drug HH204_22170 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HH204_22175 ENOG4107FB0 transcriptional regulator DeoR family HH204_22180 ENOG4105DZ1 carboxypeptidase HH204_22190 ENOG4108TGY Glutathione S-transferase HH204_22195 ENOG4105D8V Glucose sorbosone dehydrogenase HH204_22200 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HH204_22205 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HH204_22210 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HH204_22215 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HH204_22220 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HH204_22225 ENOG4105DEF Extracellular solute-binding protein, family 5 HH204_22230 ENOG4108JQ6 ABC transporter HH204_22235 ENOG4105D44 asparaginase HH204_22240 ENOG4105CVM Molybdenum cofactor synthesis domain protein HH204_22245 ENOG4105D06 uba thif-type nad fad binding protein HH204_22250 ENOG4105F1A Pyruvate formate-lyase HH204_22260 ENOG4108HCJ Hydrolase HH204_22265 ENOG41072TH Protein of unknown function (DUF1479) HH204_22270 ENOG4105ETE Transcriptional regulator (LacI family HH204_22275 ENOG4105DPW Major facilitator superfamily MFS_1 HH204_22285 ENOG4105C5H ABC transporter HH204_22290 ENOG4105M2Z protein tyrosine serine phosphatase HH204_22295 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HH204_22300 ENOG4108TZY GntR Family Transcriptional Regulator HH204_22305 ENOG4105CS2 ec 3.2.1.21 HH204_22310 ENOG4105F4P )-transporter HH204_22315 ENOG4105KST dependent repressor HH204_22325 ENOG4108I6E Sulfatase HH204_22330 ENOG4108T1M outer membrane protein x HH204_22345 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HH204_22350 ENOG4107R0W ABC transporter HH204_22355 ENOG4105E5Q amino acid AbC transporter HH204_22360 ENOG4105CDA abc transporter atp-binding protein HH204_22365 ENOG4105D8X mechanosensitive ion channel HH204_22370 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HH204_22375 ENOG4105EW6 flavin reductase domain protein, FMN-binding HH204_22385 ENOG4105KSC Transcriptional regulator, TraR DksA family HH204_22390 ENOG4105VR4 UPF0379 protein ybiJ HH204_22395 ENOG4108MTB glycosyl transferase family HH204_22400 ENOG4105DVT helicase HH204_22405 ENOG4105C1J atp-dependent rna helicase HH204_22435 ENOG4108PZW LysR family Transcriptional regulator HH204_22440 ENOG4107MVR Transcriptional regulator HH204_22445 ENOG4105D0S secretion protein (HlyD HH204_22450 ENOG4105CJ1 ABC, transporter HH204_22455 ENOG4107QWP ABC-2 type transporter HH204_22460 ENOG4107QWP ABC-2 type transporter HH204_22465 ENOG4105I9U inner membrane protein ybhQ HH204_22470 ENOG4105X23 Endonuclease Exonuclease phosphatase HH204_22475 ENOG4105DZQ phospholipase D Transphosphatidylase HH204_22480 ENOG4107UXM Membrane HH204_22490 ENOG4105HFZ Membrane HH204_22495 ENOG4108ZAF Molybdopterin HH204_22500 ENOG4105M00 molybdopterin converting factor, subunit 1 HH204_22505 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HH204_22510 ENOG4108RIR Molybdenum cofactor biosynthesis protein HH204_22515 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HH204_22520 ENOG4105CHW UPF0052 protein HH204_22525 ENOG4105DIJ Phosphoethanolamine transferase HH204_22530 ENOG4105XJC Two component transcriptional regulator (Winged helix family HH204_22535 ENOG4105ECM Sensor protein basS pmrB HH204_22540 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HH204_22550 ENOG4108IV0 ABC, transporter HH204_22560 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HH204_22565 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HH204_22570 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HH204_22575 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HH204_22580 ENOG4108V1U phospholipid-binding protein HH204_22590 ENOG4105C84 Histidine ammonia-lyase HH204_22595 ENOG4105CGP Urocanate hydratase HH204_22610 ENOG41088SP formiminoglutamate hydrolase HH204_22615 ENOG4105CI2 imidazolone-5-propionate hydrolase HH204_22620 ENOG4105NBR Pectinesterase HH204_22630 ENOG4108U51 Universal stress protein HH204_22635 ENOG4105ENT Efflux transporter rnd family, mfp subunit HH204_22640 ENOG4105BZS acriflavin resistance protein HH204_22670 ENOG4108XDN Transcriptional regulator HH204_22675 ENOG4105BZU Histidine kinase HH204_22680 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HH204_22695 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HH204_22700 ENOG4108K4B hydrolase HH204_22710 ENOG4105E0C molybdate abc transporter HH204_22715 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HH204_22725 ENOG4105F4R Transcriptional regulator mode HH204_22735 ENOG4105DKW ABC transporter HH204_22740 ENOG4105CMR udp-glucose 4-epimerase HH204_22745 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HH204_22750 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HH204_22755 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HH204_22760 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HH204_22765 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HH204_22770 ENOG4105JND homeobox protein HH204_22775 ENOG4105PGM cation diffusion facilitator family transporter HH204_22780 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HH204_22785 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HH204_22820 ENOG4105UFD tol-pal system protein YbgF HH204_22825 ENOG4105KCK Peptidoglycan-associated lipoprotein HH204_22835 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HH204_22845 ENOG4105E02 MotA TolQ exbB proton channel HH204_22850 ENOG4107YD3 Thioesterase HH204_22855 ENOG4105KJB cyd operon protein YbgE HH204_22865 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HH204_22870 ENOG4105C4M (Ubiquinol oxidase) subunit I HH204_22880 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HH204_22885 ENOG4105CMV Succinyl-CoA synthetase subunit beta HH204_22890 ENOG4105C7S Dehydrogenase HH204_22895 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HH204_22900 ENOG4105E33 succinate dehydrogenase HH204_22905 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HH204_22910 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HH204_22915 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HH204_22920 ENOG4105BZN citrate synthase HH204_22925 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HH204_22945 ENOG4105E7W lamb ycsf family protein HH204_22950 ENOG4107R7A Allophanate hydrolase subunit 2 HH204_22955 ENOG4105P4J Allophanate hydrolase, subunit 1 HH204_22960 ENOG4107QNR UPF0135 protein HH204_22965 ENOG4105DUX Transporter HH204_22970 ENOG4105CVP deoxyribo-dipyrimidine photolyase HH204_22975 ENOG4105XIQ Protein of unknown function (DUF2517) HH204_22985 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HH204_22990 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HH204_22995 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HH204_23000 ENOG4105C08 Histidine kinase HH204_23005 ENOG4105EEX Two component transcriptional regulator (Winged helix family HH204_23015 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HH204_23020 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HH204_23025 ENOG4105EV9 Alpha Beta Hydrolase HH204_23030 ENOG4105NNH LexA regulated protein HH204_23035 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HH204_23040 ENOG41090R7 Ferric uptake HH204_23045 ENOG4105CSH Transporter HH204_23050 ENOG4105GX6 (LipO)protein HH204_23055 ENOG4105J5J Outer membrane porin HH204_23065 ENOG4105CX6 glutaminyL-tRNA synthetase HH204_23070 ENOG4105CI1 PTS System HH204_23075 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HH204_23080 ENOG4105CE4 GlcNAc 6-P deacetylase HH204_23085 ENOG4105E2R ROK family HH204_23090 ENOG4105D4U had-superfamily hydrolase, subfamily iia HH204_23095 ENOG4105CAQ asparagine synthetase HH204_23135 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HH204_23140 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HH204_23145 ENOG4105C9A Phoh family HH204_23150 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HH204_23155 ENOG4108JU5 Magnesium and cobalt efflux protein HH204_23160 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HH204_23165 ENOG4107RP9 extracellular solute-binding protein, family 3 HH204_23170 ENOG4105EAD ABC transporter HH204_23175 ENOG4105DRP amino acid AbC transporter HH204_23180 ENOG4105CDA abc transporter atp-binding protein HH204_23195 ENOG4107PAI alpha helical protein HH204_23200 ENOG4105C8T Leucyl-tRNA synthetase HH204_23210 ENOG4105DJF DNA polymerase III, delta' subunit HH204_23215 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HH204_23220 ENOG4108TGR phosphatase HH204_23225 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HH204_23230 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HH204_23235 ENOG4105CJN penicillin-binding protein HH204_23240 ENOG4105CNI cell division protein FtsW HH204_23245 ENOG4105K6T rare lipoprotein A HH204_23250 ENOG4105DZ1 carboxypeptidase HH204_23255 ENOG4108Z43 UPF0250 protein HH204_23260 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HH204_23265 ENOG41064T2 transcriptional regulator, lysR family HH204_23270 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HH204_23275 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HH204_23295 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HH204_23300 ENOG4105CEE C4-dicarboxylate transporter HH204_23305 ENOG4105KTS ribonuclease HH204_23310 ENOG4105NXH GreA GreB family elongation factor HH204_23315 ENOG4108U51 Universal stress protein HH204_23320 ENOG4108JU3 Alkyl hydroperoxide reductase HH204_23325 ENOG4105D3R alkyl hydroperoxide reductase HH204_23330 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HH204_23335 ENOG4105DQS Transcriptional regulator HH204_23340 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HH204_23345 ENOG4105GTN ParB Domain Protein Nuclease HH204_23350 ENOG4105CHM Aminotransferase HH204_23355 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HH204_23360 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HH204_23375 ENOG4105C2J ABC transporter HH204_23385 ENOG4105CNN ABC, transporter HH204_23395 ENOG4108M3J Dehydrogenase HH204_23405 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HH204_23410 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HH204_23420 ENOG4105DZC cytosine deaminase HH204_23430 ENOG4105ECY inositol monophosphatase HH204_23435 ENOG4105CXY transporter HH204_23440 ENOG4105D6F Phosphatase HH204_23445 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HH204_23450 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HH204_23465 ENOG4105CNN ABC, transporter HH204_23470 ENOG4105C2J ABC transporter HH204_23475 ENOG4107SCQ Iron-containing alcohol dehydrogenase HH204_23480 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HH204_23495 ENOG4105VCD cytoplasmic protein HH204_23500 ENOG4105D22 carbon starvation protein HH204_23505 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HH204_23510 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HH204_23515 ENOG4105WQI isochorismatase HH204_23520 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HH204_23525 ENOG4105E4F Isochorismate synthase HH204_23530 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HH204_23535 ENOG4105E8G Major facilitator Superfamily HH204_23540 ENOG4105DQ5 transport system permease protein HH204_23545 ENOG4105TVJ transport system, permease HH204_23550 ENOG4105E0A ABC, transporter HH204_23555 ENOG4105C0W non-ribosomal peptide synthetase HH204_23560 ENOG41085A6 mbth domain-containing protein HH204_23565 ENOG4105E93 esterase HH204_23570 ENOG4107RNH Outer membrane receptor FepA HH204_23575 ENOG4108TSE Transferase HH204_23580 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HH204_23590 ENOG4105C2J ABC transporter HH204_23595 ENOG4105CNN ABC, transporter HH204_23600 ENOG4105DNE Transposase HH204_23605 ENOG4105DKT Transcriptional regulator HH204_23610 ENOG4108HHA Transketolase HH204_23615 ENOG4108IUS Transketolase HH204_23625 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HH204_23640 ENOG410810E transcriptional regulator, lysR family HH204_23645 ENOG4105CUY Mechanosensitive ion channel HH204_23650 ENOG4108WN0 inhibitor of vertebrate lysozyme HH204_23655 ENOG4105C94 Transporter HH204_23670 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HH204_23680 ENOG4105DEF Extracellular solute-binding protein, family 5 HH204_23685 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HH204_23690 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HH204_23700 ENOG4108JQ7 (ABC) transporter HH204_23710 ENOG4105EMU Dehydrogenase HH204_23720 ENOG4105GBT ABC transporter HH204_23725 ENOG4105DRP amino acid AbC transporter HH204_23730 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HH204_23740 ENOG4105CHM Aminotransferase HH204_23745 ENOG4105T38 integral membrane protein HH204_23750 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HH204_23765 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HH204_23780 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HH204_23785 ENOG4108T58 Mg2 transport protein CorA HH204_23810 ENOG4105WQ6 Membrane HH204_23815 ENOG4105HFT AraC family transcriptional regulator HH204_23825 ENOG410630P Transcriptional regulator HH204_23830 ENOG4105MSB protein, conserved in bacteria HH204_23835 ENOG4108RCM Nitroreductase HH204_23870 ENOG4105CUY Mechanosensitive ion channel HH204_23875 ENOG4105ETE Transcriptional regulator (LacI family HH204_23885 ENOG4105CK5 oxidoreductase HH204_23895 ENOG4105EAA nucleoside HH204_23900 ENOG4105C85 amino acid HH204_23910 ENOG4108NS2 receptor HH204_23915 ENOG4105C26 Dehydrogenase HH204_23920 ENOG4105CJP fad dependent oxidoreductase HH204_23930 ENOG4105CUB amino acid HH204_23945 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase HH204_23950 ENOG4105DGU Histone deacetylase HH204_23960 ENOG4108UAJ Transcriptional regulator HH204_23970 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HH204_23985 ENOG4105CPC Aldo Keto reductase HH204_23990 ENOG4105E89 ABC transporter HH204_23995 ENOG4105CH2 amidohydrolase HH204_24030 ENOG4105EHG Permease protein HH204_24035 ENOG4105E0A ABC, transporter HH204_24040 ENOG4105EFX secretion protein, HlyD family HH204_24045 ENOG4105KK7 inner membrane protein YiaW HH204_24060 ENOG4105D7K pfkb domain protein HH204_24065 ENOG4108M0B Sucrose porin HH204_24070 ENOG4105C5Y PTS System HH204_24075 ENOG4108HKT sucrose-6-phosphate hydrolase HH204_24080 ENOG4105WBN Transcriptional regulator (LacI family HH204_24095 ENOG4108HWV )-transporter HH204_24100 ENOG4105C2J ABC transporter HH204_24140 ENOG4105CRK lysyL-tRNA synthetase HH204_24145 ENOG4105DUX Transporter HH204_24150 ENOG4105CXN decarboxylase HH204_24155 ENOG4105D5Q Arginine ornithine antiporter HH204_24170 ENOG4105D1S lipid A biosynthesis HH204_24180 ENOG4105BZN citrate synthase HH204_24310 ENOG4105XB7 anti-repressor protein HH204_24330 ENOG4105DFP Integrase HH204_24340 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HH204_24345 ENOG4105WQ3 Rna-binding protein HH204_24350 ENOG4105C8N cysteinyl-tRNA synthetase HH204_24355 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HH204_24360 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HH204_24370 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HH204_24375 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HH204_24395 ENOG4105CV6 ABC transporter, permease HH204_24400 ENOG4108I0Y (ABC) transporter HH204_24405 ENOG4108UJV acyl-CoA thioesterase i HH204_24410 ENOG4105E1F short-chain dehydrogenase reductase HH204_24415 ENOG4107QR8 Thioredoxin HH204_24420 ENOG4105C4B ABC transporter, permease HH204_24425 ENOG41083J0 (ABC) transporter HH204_24430 ENOG4107QX8 SPFH domain, Band 7 family protein HH204_24435 ENOG4105G5H Membrane HH204_24440 ENOG4108Z6Z Transcriptional regulator HH204_24445 ENOG4105C59 p-type ATPase HH204_24450 ENOG4105MBR gumn family HH204_24455 ENOG4108Z66 YbaK ebsC protein HH204_24460 ENOG4105CGH 5'-nucleotidase HH204_24465 ENOG4105EU0 Major facilitator Superfamily HH204_24480 ENOG4105CKD glutathione-regulated potassium-efflux system protein HH204_24485 ENOG4107RE1 Inosine-guanosine kinase HH204_24495 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HH204_24500 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HH204_24505 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HH204_24510 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HH204_24515 ENOG4107QMP dna polymerase iii subunits gamma and tau HH204_24520 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HH204_24525 ENOG4105WD1 Membrane HH204_24530 ENOG4108URS primosomal replication protein n'' HH204_24535 ENOG4106428 Protein of unknown function (DUF2496) HH204_24545 ENOG4105EGS Mechanosensitive ion channel HH204_24555 ENOG4105C1P efflux transporter, rnd family, mfp subunit HH204_24560 ENOG4105BZS acriflavin resistance protein HH204_24565 ENOG4108UKR Biofilm formation regulator YbaJ HH204_24575 ENOG4108UW5 maltose o-acetyltransferase HH204_24585 ENOG4105GSJ Inner membrane protein ylaC HH204_24600 ENOG4105YK5 50S ribosomal protein L36 HH204_24610 ENOG4105ETE Transcriptional regulator (LacI family HH204_24615 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HH204_24620 ENOG4105CI1 PTS System HH204_24625 ENOG4105C4C beta-galactosidase HH204_24635 ENOG4105EG2 ABC transporter, permease HH204_24645 ENOG4107FKK extracellular solute-binding protein family 1 HH204_24660 ENOG41066DG (EAL) domain protein HH204_24665 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter HH204_24670 ENOG41061MD high-affinity nickel-transporter HH204_24705 ENOG41080UX Methyltransferase HH204_24710 ENOG4108MNP Glycoprotein polysaccharide metabolism HH204_24715 ENOG4105C29 acyl-CoA thioesterase HH204_24720 ENOG4105BZU Histidine kinase HH204_24725 ENOG4108YZA Nitrogen regulatory protein pii HH204_24730 ENOG4105BZ1 (ABC) transporter HH204_24735 ENOG4105BZ1 (ABC) transporter HH204_24740 ENOG4108XM1 transcriptional regulator AsnC family HH204_24750 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HH204_24755 ENOG4108NFA extracellular solute-binding protein HH204_24760 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HH204_24765 ENOG4108TGP Thioesterase superfamily protein HH204_24770 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HH204_24775 ENOG4105EIN peptidylprolyl cis-trans isomerase HH204_24780 ENOG4105K70 DNA-binding protein HH204_24785 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HH204_24790 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HH204_24800 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HH204_24810 ENOG4105M85 Bola protein HH204_24815 ENOG4105IEY (LipO)protein HH204_24820 ENOG4105EYM Major Facilitator superfamily HH204_24825 ENOG4105E2S oxidase) subunit II HH204_24830 ENOG4105BZ9 Cytochrome C oxidase, subunit I HH204_24835 ENOG4105CCU oxidase (Subunit III) HH204_24840 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HH204_24845 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HH204_24855 ENOG4107HP6 Transcriptional regulator HH204_24860 ENOG4105E2X shikimate dehydrogenase HH204_24865 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HH204_24875 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HH204_24885 ENOG4105D2S major facilitator superfamily HH204_24890 ENOG4105CIB oxidoreductase Domain protein HH204_24895 ENOG4107RDB Major Facilitator HH204_24905 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HH204_24910 ENOG4107S0N DJ-1 family HH204_24920 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HH204_24925 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HH204_24930 ENOG4105CTB Polyprenyl synthetase HH204_24935 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HH204_24940 ENOG4105CPC Aldo Keto reductase HH204_24945 ENOG4108ZAI phosphatidylglycerophosphatase a HH204_24950 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HH204_24955 ENOG4107YIM Involved in the transcription termination process (By similarity) HH204_24960 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HH204_24965 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HH204_24970 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HH204_24975 ENOG4108KIC (LipO)protein HH204_24980 ENOG4105DRB nucleoside-specific channel-forming protein HH204_24995 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HH204_25000 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HH204_25005 ENOG4105VIE preprotein translocase, subunit YajC HH204_25010 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HH204_25015 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HH204_25025 ENOG4108ZYK Acyl carrier protein phosphodiesterase HH204_25030 ENOG4105D3R alkyl hydroperoxide reductase HH204_25035 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HH204_25050 ENOG4108MGF sugar kinase HH204_25060 ENOG4105CI2 imidazolone-5-propionate hydrolase HH204_25070 ENOG4105CHJ isochorismatase hydrolase HH204_25075 ENOG4105EQ1 Transcriptional regulator HH204_25080 ENOG4107R28 alpha amylase, catalytic region HH204_25085 ENOG4105C85 amino acid HH204_25090 ENOG4105CWM branched-chain amino acid transport system II carrier protein HH204_25095 ENOG4105BZU Histidine kinase HH204_25100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HH204_25105 ENOG4107RH8 nuclease SbcCD subunit D HH204_25110 ENOG4105EYH Exonuclease HH204_25115 ENOG4105DKQ ROK family HH204_25120 ENOG4105DH7 May be involved in recombination (By similarity) HH204_25125 ENOG4105NBK UPF0345 protein HH204_25130 ENOG4105HBA AroM protein HH204_25135 ENOG4105SS3 HH204_25140 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HH204_25145 ENOG4105G4C Periplasmic ligand-binding sensor protein HH204_25150 ENOG4108UPT UPF0178 protein HH204_25155 ENOG4105II7 pyrroline-5-carboxylate reductase HH204_25160 ENOG4105VIF phosphate starvation-inducible protein HH204_25165 ENOG4105G6Z alkaline phosphatase HH204_25185 ENOG4105CPF Cell wall formation (By similarity) HH204_25190 ENOG4105UNH Membrane HH204_25195 ENOG4105FR5 inner membrane protein YaiY HH204_25200 ENOG4107QS8 (LipO)protein HH204_25205 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HH204_25210 ENOG4108RWI nicotinamidase HH204_25215 ENOG4107R6D beta-lactam binding protein AmpH HH204_25220 ENOG4105D52 delta-aminolevulinic acid dehydratase HH204_25225 ENOG4108UK5 Transposase HH204_25235 ENOG4105E2B Taurine dioxygenase HH204_25240 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HH204_25245 ENOG4108ETV ABC transporter HH204_25250 ENOG4106FTQ Taurine ABC transporter, periplasmic HH204_25255 ENOG4107QK5 Homocysteine s-methyltransferase HH204_25260 ENOG4108IQI permease HH204_25270 ENOG4105C85 amino acid HH204_25275 ENOG4105CPD ethanolamine ammonia-lyase HH204_25280 ENOG4107FQ9 ethanolamine ammonia-lyase HH204_25295 ENOG4105C32 Amino acid ABC transporter (Permease) HH204_25300 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HH204_25305 ENOG4105C0Z ABC transporter HH204_25310 ENOG4108IV0 ABC, transporter HH204_25320 ENOG4105CT1 (ABC) transporter HH204_25325 ENOG4105CDA abc transporter atp-binding protein HH204_25330 ENOG4105EZ7 amino acid ABC transporter HH204_25335 ENOG4105DRP amino acid AbC transporter HH204_25345 ENOG4106PYX Receptor HH204_25355 ENOG4108NN8 Fimbrial protein HH204_25360 ENOG4108GWT fimbrillin MatB HH204_25365 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon HH204_25375 ENOG4105EHI Phosphonate ABC transporter, periplasmic HH204_25385 ENOG4105S7S phosphonate abc transporter HH204_25405 ENOG4108QBX (LipO)protein HH204_25410 ENOG4105FCK Membrane HH204_25415 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HH204_25440 ENOG4105CW0 outer membrane usher protein HH204_25445 ENOG4108AF8 Chaperone HH204_25450 ENOG4106EAR Fimbrial protein HH204_25465 ENOG4108TC1 Transcriptional regulator HH204_25480 ENOG4108T1M outer membrane protein x HH204_25495 ENOG4105CXC rtn protein HH204_25515 ENOG4108VEV chaperone HH204_25540 ENOG4105DTA methyltransferase HH204_25545 ENOG4105YCT UPF0386 protein HH204_25555 ENOG4105D5U fad dependent oxidoreductase HH204_25560 ENOG4105C26 Dehydrogenase HH204_25565 ENOG4108JPW Aminotransferase HH204_25570 ENOG4105C85 amino acid HH204_25575 ENOG4108PVQ transcriptional regulator HH204_25585 ENOG4107RSM transcriptional regulator HH204_25595 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HH204_25610 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HH204_25615 ENOG4105V1F Fermentation respiration switch protein HH204_25620 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HH204_25625 ENOG4105CIN aminoacyl-histidine dipeptidase HH204_25630 ENOG4108HYG acetyltransferase HH204_25635 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HH204_25650 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HH204_25655 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HH204_25660 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HH204_25665 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HH204_25670 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HH204_25675 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HH204_25680 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HH204_25685 ENOG4105E7A Glutamine amidotransferase HH204_25690 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HH204_25695 ENOG4107QPN acyl-Coa dehydrogenase HH204_25700 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HH204_25705 ENOG4108VP3 Lysine exporter protein (LysE YggA) HH204_25710 ENOG41090KR LysR family transcriptional Regulator HH204_25720 ENOG4107RZZ dna polymerase iii epsilon subunit HH204_25725 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HH204_25730 ENOG4105D1A Methyltransferase HH204_25735 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HH204_25740 ENOG4105E9H Lytic Murein transglycosylase HH204_25745 ENOG4105F2W methyltransferase HH204_25755 ENOG4105F27 Major Facilitator HH204_25760 ENOG4105HEI LysR family (Transcriptional regulator HH204_25765 ENOG4105CV8 reductase HH204_25800 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HH204_25805 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HH204_25810 ENOG4108UMI ABC transporter, permease HH204_25815 ENOG4105D01 (LipO)protein HH204_25820 ENOG4108R8X outer membrane lipoprotein HH204_25825 ENOG4108R96 Methyltransferase, YaeB family HH204_25830 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HH204_25835 ENOG4108UY0 (LipO)protein HH204_25840 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HH204_25845 ENOG4108YZN class I peptide chain release factor HH204_25850 ENOG4108VWS Yaeq family HH204_25855 ENOG4105W1I UPF0253 protein HH204_25860 ENOG4105M1T rho-binding antiterminator HH204_25865 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HH204_25870 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HH204_25875 ENOG4105CXN decarboxylase HH204_25880 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HH204_25885 ENOG4105C0B DNA polymerase III (alpha subunit) HH204_25890 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HH204_25895 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HH204_25900 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HH204_25905 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HH204_25910 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HH204_25915 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HH204_25920 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HH204_25925 ENOG4105DZP Membrane-associated zinc metalloprotease HH204_25930 ENOG4105KNE Phosphatidate cytidylyltransferase HH204_25940 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HH204_25950 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HH204_25955 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HH204_25960 ENOG4105CE9 30S ribosomal protein S2 HH204_25965 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HH204_25970 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HH204_25975 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HH204_25980 ENOG4108T8E UPF0325 protein HH204_25985 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HH204_25990 ENOG4105C0H protease HH204_25995 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HH204_26000 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HH204_26005 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HH204_26010 ENOG4105EN6 Membrane HH204_26015 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HH204_26020 ENOG4105CMQ Chloride channel HH204_26025 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HH204_26030 ENOG4105S6R Iron-hydroxamate transporter permease subunit HH204_26035 ENOG4105J76 Periplasmic binding protein HH204_26040 ENOG4105E0A ABC, transporter HH204_26045 ENOG4105E0K tonB-dependent siderophore receptor HH204_26050 ENOG4105BZ4 penicillin-binding protein HH204_26145 ENOG4105CQ7 ATP-dependent helicase HH204_26150 ENOG4107XID 2'-5' rna ligase HH204_26155 ENOG4105PW4 Sugar fermentation stimulation protein homolog HH204_26160 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HH204_26165 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HH204_26170 ENOG4105DJ0 Poly(A) Polymerase HH204_26175 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HH204_26180 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HH204_26185 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HH204_26190 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HH204_26195 ENOG4107BJW polysaccharide deacetylase HH204_26200 ENOG4108YTN IIa component HH204_26205 ENOG4105E3A (ABC) transporter HH204_26210 ENOG4105DA5 (ABC) transporter HH204_26215 ENOG41077A9 carbonic anhydrase HH204_26220 ENOG4108UGV hypoxanthine phosphoribosyltransferase HH204_26230 ENOG4105DZG Dehydrogenase HH204_26235 ENOG4105E3B Multicopper oxidase HH204_26240 ENOG4108ZRK uncharacterized protein yacC HH204_26260 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HH204_26265 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HH204_26270 ENOG4108ZIG UPF0231 protein HH204_26275 ENOG4107QIJ Aconitate hydratase 2 HH204_26300 ENOG4107QN2 dihydrolipoyl dehydrogenase HH204_26305 ENOG4107QSN dihydrolipoamide acetyltransferase HH204_26310 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HH204_26315 ENOG41073TP transcriptional regulator HH204_26320 ENOG4105C85 amino acid HH204_26325 ENOG4105CT4 transporter HH204_26330 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HH204_26335 ENOG4106A72 regulatory protein AmpE HH204_26340 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HH204_26345 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HH204_26350 ENOG4108ZUW Major pilin subunit HH204_26355 ENOG4107QHF type ii secretion system protein e HH204_26360 ENOG4105D7Q type ii secretion system HH204_26365 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HH204_26375 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HH204_26380 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HH204_26385 ENOG4105M6F mutator MutT protein HH204_26390 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HH204_26395 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HH204_26400 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HH204_26405 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HH204_26410 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HH204_26415 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HH204_26425 ENOG4105DFU Cell wall formation (By similarity) HH204_26430 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HH204_26435 ENOG4105CNI cell division protein FtsW HH204_26515 ENOG4107U2T alpha beta HH204_26545 ENOG4105DWP Membrane HH204_26550 ENOG4108XM1 transcriptional regulator AsnC family HH204_26600 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HH204_26650 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HH204_26655 ENOG4105DUU IucA IucC family protein HH204_26710 ENOG4105CKI cobalamin synthesis protein HH204_26715 ENOG4108WF3 methyltransferase HH204_26730 ENOG4105EHG Permease protein HH204_26740 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HH204_26775 ENOG4105BZU Histidine kinase HH204_26810 ENOG410624V efflux system protein HH204_26850 ENOG4105DR5 peptidase HH204_26860 ENOG4105E3B Multicopper oxidase HH204_26865 ENOG4105VR0 copper resistance HH204_26870 ENOG4105JDN Copper resistance protein HH204_26875 ENOG4108PG2 copper resistance HH204_26880 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HH204_26885 ENOG4105GR3 Histidine kinase HH204_26890 ENOG4105VUF Transcriptional regulator HH204_26920 ENOG4105KF5 hemolysin expression-modulating protein HH204_26950 ENOG4105D52 delta-aminolevulinic acid dehydratase HH204_26955 ENOG4105CD3 dihydroorotase HH204_26995 ENOG4105CKI cobalamin synthesis protein HH204_27010 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase HH204_27065 ENOG4108HUF Transporter HH204_27070 ENOG4105GAV receptor HH204_27080 ENOG4108SF5 RNA Polymerase HH204_27095 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HH204_27100 ENOG4105GTN ParB Domain Protein Nuclease HH204_27120 ENOG4105E93 esterase HH204_27125 ENOG4107RNH Outer membrane receptor FepA HH204_27135 ENOG4105DWP Membrane HH204_27140 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HH204_27155 ENOG4108WF3 methyltransferase HH204_27305 ENOG4108YXQ IS66 Orf2 family protein HH204_27310 ENOG4105E5H Transposase HH204_27365 ENOG4105KF5 hemolysin expression-modulating protein HH204_27380 ENOG4106JVB Replication Protein HH204_27395 ENOG4107SQD Transcriptional regulator, GntR family HH204_27435 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HH204_27455 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) HH204_27480 ENOG4108M24 von Willebrand factor, type A HH204_27485 ENOG4108M24 von Willebrand factor, type A HH204_27495 ENOG4108M24 von Willebrand factor, type A