locus-tag	class	description
HCV84_000020	COG0187	DNA topoisomerase II activity
HCV84_000025	COG0561	phosphatase activity
HCV84_000040	COG2186	Transcriptional regulator
HCV84_000045	COG3734	2-keto-3-deoxy-galactonokinase
HCV84_000050	COG0800	Aldolase
HCV84_000060	COG2271	Major facilitator Superfamily
HCV84_000065	COG0823	Involved in the tonB-independent uptake of proteins
HCV84_000070	COG5645	(Lipo)protein
HCV84_000085	COG3645	SOS response
HCV84_000095	COG2188	Transcriptional regulator
HCV84_000110	COG2149	membrane
HCV84_000130	COG2610	gluconate transmembrane transporter activity
HCV84_000140	COG0583	DNA-binding transcription factor activity
HCV84_000145	COG2814	Major facilitator Superfamily
HCV84_000175	COG0028	Belongs to the TPP enzyme family
HCV84_000180	COG0440	acetolactate synthase activity
HCV84_000185	COG2197	response regulator
HCV84_000195	COG2271	Major facilitator Superfamily
HCV84_000235	COG2188	Transcriptional regulator
HCV84_000260	COG4580	involved in the transport of maltose and maltodextrins
HCV84_000265	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCV84_000270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV84_000270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV84_000280	COG1609	Transcriptional regulator
HCV84_000295	COG0583	DNA-binding transcription factor activity
HCV84_000300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCV84_000305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HCV84_000310	COG2828	Protein conserved in bacteria
HCV84_000325	COG0697	spore germination
HCV84_000330	COG1263	PTS System
HCV84_000330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV84_000340	COG2814	Major facilitator Superfamily
HCV84_000350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCV84_000385	COG0583	DNA-binding transcription factor activity
HCV84_000410	COG1464	Belongs to the NlpA lipoprotein family
HCV84_000425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HCV84_000435	COG1064	alcohol dehydrogenase
HCV84_000465	COG2211	Major facilitator Superfamily
HCV84_000470	COG1501	Belongs to the glycosyl hydrolase 31 family
HCV84_000480	COG1486	melibiose metabolic process
HCV84_000485	COG1263	PTS System
HCV84_000485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV84_000490	COG2982	Protein involved in outer membrane biogenesis
HCV84_000495	COG2233	PERMEase
HCV84_000500	COG0786	glutamate:sodium symporter activity
HCV84_000520	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HCV84_000545	COG3152	Membrane
HCV84_000555	COG1494	fructose-1,6-bisphosphatase
HCV84_000560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCV84_000565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCV84_000570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCV84_000590	COG2860	membrane
HCV84_000600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCV84_000600	COG2169	Transcriptional regulator
HCV84_000605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HCV84_000610	COG1561	YicC-like family, N-terminal region
HCV84_000630	COG1131	(ABC) transporter
HCV84_000635	COG0842	Transport permease protein
HCV84_000665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCV84_000700	COG1519	Transferase
HCV84_000705	COG1216	Glycosyl transferase, family 2
HCV84_000710	COG0438	transferase activity, transferring glycosyl groups
HCV84_000720	COG0859	PFAM glycosyl transferase family 9
HCV84_000745	COG0859	PFAM glycosyl transferase family 9
HCV84_000760	COG0156	8-amino-7-oxononanoate synthase activity
HCV84_000770	COG0463	Glycosyl transferase, family 2
HCV84_000775	COG2861	carbohydrate metabolic process
HCV84_000780	COG4942	peptidase
HCV84_000790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCV84_000795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCV84_000815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HCV84_000825	COG2186	Transcriptional regulator
HCV84_000845	COG3722	fumarate hydratase activity
HCV84_000865	COG0625	glutathione transferase activity
HCV84_000875	COG3276	selenocysteine insertion sequence binding
HCV84_000880	COG1414	Transcriptional regulator
HCV84_000885	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCV84_000890	COG3977	Valine--pyruvate aminotransferase
HCV84_000895	COG0366	Alpha amylase catalytic
HCV84_000900	COG2992	FlgJ-related protein
HCV84_000905	COG1609	Transcriptional regulator
HCV84_000905	COG2207	Transcriptional regulator
HCV84_000910	COG4214	carbohydrate transport
HCV84_000920	COG4213	ABC transporter substrate-binding protein
HCV84_000935	COG4682	membrane
HCV84_000940	COG4682	membrane
HCV84_000945	COG3274	enterobacterial common antigen metabolic process
HCV84_000975	COG1278	Cold shock
HCV84_000980	COG2944	sequence-specific DNA binding
HCV84_000985	COG2814	Major facilitator Superfamily
HCV84_001005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV84_001015	COG1609	Transcriptional regulator
HCV84_001020	COG2885	chlorophyll binding
HCV84_001025	COG0243	molybdopterin cofactor binding
HCV84_001030	COG0456	acetyltransferase
HCV84_001035	COG2818	Glycosylase
HCV84_001040	COG5571	outer membrane autotransporter
HCV84_001045	COG2223	nitrite transmembrane transporter activity
HCV84_001065	COG0747	negative chemotaxis
HCV84_001070	COG0601	transmembrane transport
HCV84_001075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCV84_001080	COG0444	Belongs to the ABC transporter superfamily
HCV84_001085	COG4608	Belongs to the ABC transporter superfamily
HCV84_001100	COG2894	cell division
HCV84_001110	COG1215	transferase activity, transferring glycosyl groups
HCV84_001115	COG0457	Tetratricopeptide repeat
HCV84_001130	COG2194	sulfuric ester hydrolase activity
HCV84_001160	COG1215	transferase activity, transferring glycosyl groups
HCV84_001165	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HCV84_001170	COG0457	Tetratricopeptide repeat
HCV84_001170	COG3118	belongs to the thioredoxin family
HCV84_001175	COG2200	EAL domain
HCV84_001175	COG2199	diguanylate cyclase activity
HCV84_001185	COG0612	Peptidase, M16
HCV84_001195	COG2982	Protein involved in outer membrane biogenesis
HCV84_001200	COG0477	Major facilitator Superfamily
HCV84_001205	COG1295	ribonuclease BN
HCV84_001210	COG0583	DNA-binding transcription factor activity
HCV84_001215	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_001220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCV84_001230	COG1454	alcohol dehydrogenase
HCV84_001240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCV84_001245	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HCV84_001250	COG0671	phosphoesterase, PA-phosphatase related
HCV84_001270	COG0589	response to stress
HCV84_001280	COG0306	phosphate transporter
HCV84_001285	COG2081	HI0933 family
HCV84_001290	COG2239	Acts as a magnesium transporter
HCV84_001305	COG1124	(ABC) transporter
HCV84_001315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCV84_001320	COG0601	transmembrane transport
HCV84_001325	COG0747	negative chemotaxis
HCV84_001335	COG3479	Phenolic acid decarboxylase
HCV84_001375	COG0628	permease
HCV84_001380	COG0477	Major facilitator Superfamily
HCV84_001390	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HCV84_001405	COG3714	YhhN family
HCV84_001415	COG3776	membrane
HCV84_001420	COG0742	ribosomal rna small subunit methyltransferase
HCV84_001425	COG0552	protein localization to endoplasmic reticulum
HCV84_001430	COG2884	Cell division ATP-binding protein ftsE
HCV84_001435	COG2177	Part of the ABC transporter FtsEX involved in
HCV84_001450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCV84_001460	COG0683	leucine binding
HCV84_001470	COG0683	leucine binding
HCV84_001475	COG0559	Belongs to the binding-protein-dependent transport system permease family
HCV84_001525	COG0584	glycerophosphoryl diester phosphodiesterase
HCV84_001535	COG0405	Gamma-glutamyltransferase
HCV84_001540	COG1247	-acetyltransferase
HCV84_001550	COG0673	inositol 2-dehydrogenase activity
HCV84_001555	COG1741	Belongs to the pirin family
HCV84_001560	COG1609	Transcriptional regulator
HCV84_001565	COG3265	gluconokinase activity
HCV84_001570	COG2610	gluconate transmembrane transporter activity
HCV84_001580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCV84_001605	COG0058	SHG alpha-glucan phosphorylase activity
HCV84_001610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HCV84_001625	COG1349	DNA-binding transcription factor activity
HCV84_001635	COG0058	SHG alpha-glucan phosphorylase activity
HCV84_001640	COG1640	4-alpha-glucanotransferase
HCV84_001645	COG2610	gluconate transmembrane transporter activity
HCV84_001655	COG1040	competence protein
HCV84_001680	COG1918	ferrous iron import across plasma membrane
HCV84_001685	COG2183	response to ionizing radiation
HCV84_001690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCV84_001715	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HCV84_001720	COG1011	Hydrolase
HCV84_001730	COG0494	nUDIX hydrolase
HCV84_001735	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HCV84_001760	COG4796	Type ii and iii secretion system protein
HCV84_001775	COG3266	domain, Protein
HCV84_001780	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HCV84_001785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCV84_001810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCV84_001815	COG0402	S-adenosylhomocysteine deaminase activity
HCV84_001820	COG0738	Major facilitator superfamily
HCV84_001845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCV84_001850	COG1289	transmembrane transporter activity
HCV84_001860	COG1765	OsmC-like protein
HCV84_001865	COG3954	Phosphoribulokinase
HCV84_001875	COG0429	hydrolase of the alpha beta-hydrolase fold
HCV84_001880	COG0488	(ABC) transporter
HCV84_001895	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HCV84_001900	COG1047	Peptidyl-prolyl cis-trans
HCV84_001910	COG0545	Peptidyl-prolyl cis-trans isomerase
HCV84_001915	COG2964	Protein conserved in bacteria
HCV84_001970	COG0051	transcription antitermination factor activity, RNA binding
HCV84_001995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HCV84_002010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HCV84_002075	COG0201	protein transport
HCV84_002100	COG0202	RNA polymerase activity
HCV84_002115	COG0789	Transcriptional regulator
HCV84_002120	COG3036	rescue of stalled ribosome
HCV84_002150	COG0758	DNA mediated transformation
HCV84_002160	COG0551	DNA topoisomerase type I activity
HCV84_002180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCV84_002220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCV84_002225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV84_002230	COG1309	transcriptional regulator
HCV84_002250	COG4145	pantothenate transmembrane transporter activity
HCV84_002255	COG3924	membrane
HCV84_002260	COG0439	Biotin carboxylase
HCV84_002265	COG0511	ligase activity, forming carbon-carbon bonds
HCV84_002290	COG2200	EAL domain
HCV84_002290	COG2199	diguanylate cyclase activity
HCV84_002295	COG1077	Cell shape determining protein MreB Mrl
HCV84_002300	COG1792	Involved in formation and maintenance of cell shape
HCV84_002305	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HCV84_002315	COG1530	ribonuclease E activity
HCV84_002320	COG3164	Protein of unknown function
HCV84_002325	COG0312	modulator of DNA gyrase
HCV84_002330	COG0583	DNA-binding transcription factor activity
HCV84_002345	COG1289	transmembrane transporter activity
HCV84_002350	COG2732	(Barnase) inhibitor
HCV84_002385	COG0471	metal ion transport
HCV84_002390	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HCV84_002395	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HCV84_002420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCV84_002425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCV84_002430	COG3105	Protein conserved in bacteria
HCV84_002435	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HCV84_002455	COG0625	glutathione transferase activity
HCV84_002460	COG2969	positive regulation of protein catabolic process
HCV84_002470	COG0493	'glutamate synthase
HCV84_002475	COG0067	glutamate synthase
HCV84_002475	COG0069	glutamate synthase activity
HCV84_002475	COG0070	glutamate synthase
HCV84_002480	COG1242	4 iron, 4 sulfur cluster binding
HCV84_002485	COG2271	Major facilitator Superfamily
HCV84_002490	COG1063	alcohol dehydrogenase
HCV84_002495	COG1312	Catalyzes the dehydration of D-mannonate
HCV84_002500	COG0784	Response regulator, receiver
HCV84_002500	COG2198	Histidine kinase
HCV84_002500	COG5002	protein histidine kinase activity
HCV84_002505	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HCV84_002510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCV84_002515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV84_002525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV84_002530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCV84_002535	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HCV84_002540	COG1137	ATPase activity
HCV84_002545	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HCV84_002550	COG3117	lipopolysaccharide transmembrane transporter activity
HCV84_002555	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HCV84_002565	COG0530	calcium, potassium:sodium antiporter activity
HCV84_002570	COG1127	ABC transporter
HCV84_002575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HCV84_002580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HCV84_002585	COG2854	intermembrane phospholipid transfer
HCV84_002590	COG3113	response to antibiotic
HCV84_002595	COG5007	Belongs to the BolA IbaG family
HCV84_002605	COG3423	Transcriptional regulator
HCV84_002610	COG0142	geranyltranstransferase activity
HCV84_002625	COG0697	spore germination
HCV84_002635	COG2027	D-alanyl-D-alanine carboxypeptidase
HCV84_002645	COG1534	Rna-binding protein
HCV84_002655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCV84_002660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCV84_002670	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCV84_002710	COG0195	Participates in both transcription termination and antitermination
HCV84_002755	COG0814	amino acid
HCV84_002760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCV84_002765	COG0826	peptidase U32
HCV84_002770	COG0826	peptidase U32
HCV84_002775	COG3154	lipid carrier protein
HCV84_002780	COG3153	acetyltransferase
HCV84_002795	COG0693	protein deglycase activity
HCV84_002800	COG0702	epimerase
HCV84_002805	COG0701	Predicted permease
HCV84_002810	COG2823	Periplasmic or secreted lipoprotein
HCV84_002830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HCV84_002835	COG2721	sulfolactate sulfo-lyase activity
HCV84_002840	COG2271	Major facilitator Superfamily
HCV84_002850	COG2084	Dehydrogenase
HCV84_002855	COG1929	Belongs to the glycerate kinase type-1 family
HCV84_002880	COG1741	Belongs to the pirin family
HCV84_002885	COG0583	DNA-binding transcription factor activity
HCV84_002890	COG3152	Membrane
HCV84_002895	COG0435	Glutathione S-transferase
HCV84_002900	COG2259	Doxx family
HCV84_002910	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HCV84_002915	COG4575	ribosome binding
HCV84_002920	COG1422	Protein of unknown function (DUF1090)
HCV84_002930	COG0586	Pfam SNARE associated Golgi protein
HCV84_002935	COG2186	Transcriptional regulator
HCV84_002940	COG2271	Major facilitator Superfamily
HCV84_002950	COG2721	sulfolactate sulfo-lyase activity
HCV84_002965	COG0861	Integral membrane protein TerC family
HCV84_002970	COG0673	inositol 2-dehydrogenase activity
HCV84_002975	COG1451	nucleotide metabolic process
HCV84_002995	COG0446	pyridine nucleotide-disulphide oxidoreductase
HCV84_002995	COG1902	pentaerythritol trinitrate reductase activity
HCV84_003045	COG1695	Transcriptional regulator
HCV84_003050	COG2375	cellular response to nickel ion
HCV84_003065	COG1461	Dihydroxyacetone kinase
HCV84_003070	COG2376	Dihydroxyacetone kinase
HCV84_003140	COG3247	response to pH
HCV84_003150	COG2198	Histidine kinase
HCV84_003150	COG2205	protein histidine kinase activity
HCV84_003150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV84_003150	COG0784	Response regulator, receiver
HCV84_003155	COG2197	response regulator
HCV84_003180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCV84_003185	COG0358	DNA primase activity
HCV84_003190	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCV84_003255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCV84_003270	COG4991	sh3 domain protein
HCV84_003275	COG3025	triphosphatase activity
HCV84_003300	COG2960	long-chain fatty acid transporting porin activity
HCV84_003315	COG3384	dioxygenase
HCV84_003320	COG0754	glutathionylspermidine amidase activity
HCV84_003335	COG0494	nUDIX hydrolase
HCV84_003340	COG3151	Protein conserved in bacteria
HCV84_003345	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HCV84_003350	COG3150	esterase
HCV84_003360	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HCV84_003365	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCV84_003370	COG0642	Histidine kinase
HCV84_003380	COG3111	PFAM Bacterial OB fold (BOF) protein
HCV84_003385	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HCV84_003390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCV84_003395	COG0204	Acyl-transferase
HCV84_003400	COG2132	Multicopper oxidase
HCV84_003405	COG1032	radical SAM domain protein
HCV84_003415	COG0656	L-ascorbic acid biosynthetic process
HCV84_003420	COG1979	alcohol dehydrogenase
HCV84_003425	COG2207	Transcriptional regulator
HCV84_003430	COG0586	Pfam SNARE associated Golgi protein
HCV84_003435	COG0626	cystathionine gamma-synthase activity
HCV84_003445	COG0848	biopolymer transport protein
HCV84_003450	COG2211	Major facilitator Superfamily
HCV84_003475	COG0625	glutathione transferase activity
HCV84_003490	COG0754	glutathionylspermidine amidase activity
HCV84_003495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCV84_003515	COG0583	DNA-binding transcription factor activity
HCV84_003520	COG0626	cystathionine gamma-synthase activity
HCV84_003535	COG3121	Chaperone
HCV84_003550	COG3121	Chaperone
HCV84_003555	COG3121	Chaperone
HCV84_003560	COG3188	usher protein
HCV84_003585	COG1811	Na channel or pump
HCV84_003590	COG1982	Orn Lys Arg decarboxylase major
HCV84_003595	COG2211	Major facilitator Superfamily
HCV84_003610	COG1194	a g-specific adenine glycosylase
HCV84_003620	COG3171	Protein conserved in bacteria
HCV84_003630	COG4214	carbohydrate transport
HCV84_003645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCV84_003660	COG0762	integral membrane protein
HCV84_003665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HCV84_003670	COG2805	Type II/IV secretion system protein
HCV84_003690	COG0189	ligase activity
HCV84_003695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HCV84_003700	COG2356	endonuclease I
HCV84_003710	COG2814	Major facilitator Superfamily
HCV84_003745	COG0501	Belongs to the peptidase M48B family
HCV84_003750	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HCV84_003765	COG0191	fructose-bisphosphate aldolase activity
HCV84_003770	COG0668	transmembrane transport
HCV84_003780	COG2968	Membrane
HCV84_003795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCV84_003800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HCV84_003820	COG0006	proline dipeptidase activity
HCV84_003825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCV84_003830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCV84_003850	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_003855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCV84_003875	COG2723	6-phospho-beta-galactosidase activity
HCV84_003880	COG1737	Transcriptional regulator
HCV84_003890	COG1272	protein, Hemolysin III
HCV84_003900	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HCV84_003910	COG0716	FMN binding
HCV84_003915	COG4974	Belongs to the 'phage' integrase family
HCV84_003925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCV84_003945	COG1811	Na channel or pump
HCV84_003955	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCV84_003960	COG0583	DNA-binding transcription factor activity
HCV84_003965	COG4942	peptidase
HCV84_003975	COG2814	Major facilitator Superfamily
HCV84_003990	COG0667	Aldo Keto reductase
HCV84_004030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCV84_004035	COG1393	Belongs to the ArsC family
HCV84_004050	COG1538	Outer membrane efflux protein
HCV84_004055	COG1289	transmembrane transporter activity
HCV84_004070	COG3592	Divergent 4Fe-4S mono-cluster
HCV84_004075	COG2388	GCN5-related N-acetyl-transferase
HCV84_004085	COG3539	Fimbrial protein
HCV84_004090	COG3539	Fimbrial protein
HCV84_004095	COG3539	Fimbrial protein
HCV84_004100	COG3188	usher protein
HCV84_004105	COG3121	Chaperone
HCV84_004110	COG3539	Fimbrial protein
HCV84_004120	COG4974	Belongs to the 'phage' integrase family
HCV84_004125	COG0582	viral genome integration into host DNA
HCV84_004130	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HCV84_004135	COG1846	Transcriptional regulator
HCV84_004140	COG0697	spore germination
HCV84_004190	COG0667	Aldo Keto reductase
HCV84_004195	COG0814	amino acid
HCV84_004210	COG0183	Belongs to the thiolase family
HCV84_004220	COG0823	Involved in the tonB-independent uptake of proteins
HCV84_004225	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_004230	COG2814	Major facilitator Superfamily
HCV84_004265	COG3842	ATPase activity
HCV84_004270	COG0395	ABC-type sugar transport system, permease component
HCV84_004275	COG1175	transmembrane transport
HCV84_004280	COG1917	Cupin 2, conserved barrel domain protein
HCV84_004285	COG1794	racemase activity, acting on amino acids and derivatives
HCV84_004290	COG0583	DNA-binding transcription factor activity
HCV84_004300	COG1609	Transcriptional regulator
HCV84_004305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV84_004310	COG2723	6-phospho-beta-galactosidase activity
HCV84_004315	COG2186	Transcriptional regulator
HCV84_004325	COG1609	Transcriptional regulator
HCV84_004345	COG0667	Aldo Keto reductase
HCV84_004355	COG0861	Integral membrane protein TerC family
HCV84_004390	COG2165	general secretion pathway protein
HCV84_004395	COG4795	General secretion pathway protein
HCV84_004405	COG4967	type IV pilus modification protein PilV
HCV84_004410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HCV84_004415	COG1025	Belongs to the peptidase M16 family
HCV84_004420	COG1074	ATP-dependent DNA helicase activity
HCV84_004425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HCV84_004435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HCV84_004435	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HCV84_004440	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCV84_004445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCV84_004475	COG4656	Part of a membrane complex involved in electron transport
HCV84_004480	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_004480	COG1454	alcohol dehydrogenase
HCV84_004510	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HCV84_004715	COG2885	chlorophyll binding
HCV84_004750	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HCV84_004755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HCV84_004760	COG2166	iron-sulfur cluster assembly
HCV84_004765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCV84_004775	COG0583	DNA-binding transcription factor activity
HCV84_004780	COG2363	Small membrane protein
HCV84_004790	COG1349	DNA-binding transcription factor activity
HCV84_004810	COG0738	Major facilitator superfamily
HCV84_004815	COG0235	Class ii aldolase
HCV84_004820	COG1454	alcohol dehydrogenase
HCV84_004840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCV84_004855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCV84_004860	COG2011	ABC-type metal ion transport system permease component
HCV84_004865	COG1464	Belongs to the NlpA lipoprotein family
HCV84_004870	COG0477	Major facilitator Superfamily
HCV84_004880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCV84_004885	COG1760	l-serine dehydratase
HCV84_004890	COG0814	amino acid
HCV84_004895	COG1611	Belongs to the LOG family
HCV84_004910	COG3098	single-species biofilm formation
HCV84_004915	COG0564	pseudouridine synthase activity
HCV84_004920	COG0716	FMN binding
HCV84_004925	COG2271	Major facilitator Superfamily
HCV84_004930	COG4948	Mandelate Racemase Muconate Lactonizing
HCV84_004935	COG4948	Mandelate Racemase Muconate Lactonizing
HCV84_004940	COG1929	Belongs to the glycerate kinase type-1 family
HCV84_004945	COG4999	Histidine kinase
HCV84_004945	COG3437	response regulator, receiver
HCV84_004945	COG3850	Histidine kinase
HCV84_004945	COG2205	protein histidine kinase activity
HCV84_004955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCV84_004960	COG3956	TIGRFAM MazG family protein
HCV84_004980	COG0602	queuosine metabolic process
HCV84_004985	COG0720	synthase
HCV84_005005	COG2234	aminopeptidase activity
HCV84_005065	COG4942	peptidase
HCV84_005065	COG1388	LysM domain
HCV84_005070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCV84_005095	COG0163	prenyltransferase activity
HCV84_005100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCV84_005140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV84_005145	COG4558	Periplasmic binding protein
HCV84_005150	COG3720	iron ion transport
HCV84_005170	COG0679	Auxin Efflux Carrier
HCV84_005185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCV84_005190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCV84_005195	COG1121	(ABC) transporter
HCV84_005200	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCV84_005205	COG1609	Transcriptional regulator
HCV84_005210	COG1940	carbohydrate kinase activity
HCV84_005215	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCV84_005220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV84_005225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV84_005230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV84_005235	COG4580	involved in the transport of maltose and maltodextrins
HCV84_005245	COG2723	6-phospho-beta-galactosidase activity
HCV84_005255	COG0309	Hydrogenase expression formation protein (HypE)
HCV84_005260	COG0409	Hydrogenase expression formation protein
HCV84_005265	COG0298	carbon dioxide binding
HCV84_005270	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HCV84_005285	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCV84_005290	COG0651	ATP synthesis coupled electron transport
HCV84_005295	COG0650	Formate hydrogenlyase subunit 4
HCV84_005300	COG3261	NADH dehydrogenase
HCV84_005300	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HCV84_005305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCV84_005310	COG3260	NADH ubiquinone oxidoreductase 20
HCV84_005320	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HCV84_005330	COG2723	6-phospho-beta-galactosidase activity
HCV84_005335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV84_005335	COG1263	PTS System
HCV84_005340	COG1609	Transcriptional regulator
HCV84_005345	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCV84_005350	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HCV84_005355	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HCV84_005380	COG1349	DNA-binding transcription factor activity
HCV84_005385	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV84_005390	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_005400	COG3732	PTS system glucitol sorbitol-specific
HCV84_005405	COG3730	PTS system glucitol sorbitol-specific
HCV84_005410	COG2951	lytic endotransglycosylase activity
HCV84_005415	COG1121	(ABC) transporter
HCV84_005420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCV84_005425	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCV84_005430	COG1546	Belongs to the CinA family
HCV84_005450	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HCV84_005480	COG2823	Periplasmic or secreted lipoprotein
HCV84_005485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCV84_005490	COG1238	metal cluster binding
HCV84_005510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCV84_005515	COG2814	Major facilitator Superfamily
HCV84_005520	COG1566	PFAM secretion protein HlyD family protein
HCV84_005525	COG1846	Transcriptional regulator
HCV84_005535	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HCV84_005545	COG4176	ABC-type proline glycine betaine transport system permease component
HCV84_005560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCV84_005570	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCV84_005575	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCV84_005580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCV84_005585	COG4575	ribosome binding
HCV84_005600	COG2916	Histone family protein nucleoid-structuring protein H-NS
HCV84_005615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCV84_005620	COG0640	Transcriptional regulator
HCV84_005630	COG0583	DNA-binding transcription factor activity
HCV84_005635	COG3284	Transcriptional regulator
HCV84_005645	COG3539	Fimbrial protein
HCV84_005650	COG3121	Chaperone
HCV84_005670	COG3188	usher protein
HCV84_005680	COG3539	Fimbrial protein
HCV84_005685	COG2197	response regulator
HCV84_005700	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_005710	COG0235	Class ii aldolase
HCV84_005720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV84_005745	COG1959	2 iron, 2 sulfur cluster binding
HCV84_005760	COG3708	Transcriptional regulator
HCV84_005760	COG2207	Transcriptional regulator
HCV84_005790	COG2867	negative regulation of translational initiation
HCV84_005805	COG0497	DNA recombination
HCV84_005820	COG4536	flavin adenine dinucleotide binding
HCV84_005825	COG4137	Cytochrome C assembly protein
HCV84_005830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HCV84_005865	COG2885	chlorophyll binding
HCV84_005870	COG2199	diguanylate cyclase activity
HCV84_005880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HCV84_005885	COG1605	Chorismate mutase
HCV84_005885	COG0287	Prephenate dehydrogenase
HCV84_005895	COG0077	Prephenate dehydratase
HCV84_005895	COG1605	Chorismate mutase
HCV84_005905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCV84_005910	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCV84_005925	COG0542	response to heat
HCV84_005950	COG0477	Major facilitator Superfamily
HCV84_005955	COG5544	Lipoprotein
HCV84_005960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCV84_005970	COG3148	PFAM DTW domain containing protein
HCV84_005975	COG3118	belongs to the thioredoxin family
HCV84_005980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCV84_005995	COG0513	Belongs to the DEAD box helicase family
HCV84_006005	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCV84_006020	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HCV84_006025	COG3026	antisigma factor binding
HCV84_006030	COG3086	response to oxidative stress
HCV84_006065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HCV84_006120	COG1484	DNA-dependent DNA replication
HCV84_006185	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HCV84_006190	COG0484	heat shock protein binding
HCV84_006205	COG3772	lysozyme
HCV84_006230	COG5410	chromosome segregation
HCV84_006310	COG1196	nuclear chromosome segregation
HCV84_006310	COG0739	heme binding
HCV84_006310	COG0741	lytic transglycosylase activity
HCV84_006380	COG5484	DNA packaging
HCV84_006380	COG3728	DNA packaging
HCV84_006430	COG3756	Protein conserved in bacteria
HCV84_006435	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HCV84_006465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HCV84_006515	COG0516	GMP reductase activity
HCV84_006515	COG0517	IMP dehydrogenase activity
HCV84_006525	COG1645	bacterial-type flagellum-dependent swarming motility
HCV84_006545	COG2976	Protein conserved in bacteria
HCV84_006575	COG4953	penicillin-binding protein 1C
HCV84_006580	COG2373	Large extracellular alpha-helical protein
HCV84_006585	COG2897	thiosulfate sulfurtransferase activity
HCV84_006605	COG2975	iron-sulfur cluster assembly
HCV84_006610	COG0633	Ferredoxin
HCV84_006630	COG0822	iron-sulfur transferase activity
HCV84_006660	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HCV84_006665	COG3683	transport system, periplasmic component
HCV84_006670	COG3711	transcriptional antiterminator
HCV84_006675	COG2814	Major facilitator Superfamily
HCV84_006680	COG2017	converts alpha-aldose to the beta-anomer
HCV84_006685	COG2814	Major facilitator Superfamily
HCV84_006685	COG0477	Major facilitator Superfamily
HCV84_006690	COG0457	Tetratricopeptide repeat
HCV84_006695	COG1940	carbohydrate kinase activity
HCV84_006700	COG2259	Doxx family
HCV84_006710	COG1017	nitric oxide dioxygenase activity
HCV84_006710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCV84_006715	COG0347	Belongs to the P(II) protein family
HCV84_006720	COG2204	response regulator
HCV84_006725	COG3170	Tfp pilus assembly protein FimV
HCV84_006730	COG2205	protein histidine kinase activity
HCV84_006735	COG0047	phosphoribosylformylglycinamidine synthase activity
HCV84_006735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCV84_006750	COG0560	Phosphoserine phosphatase
HCV84_006755	COG1737	Transcriptional regulator
HCV84_006760	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCV84_006770	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HCV84_006790	COG0681	Belongs to the peptidase S26 family
HCV84_006845	COG1196	nuclear chromosome segregation
HCV84_006925	COG3728	DNA packaging
HCV84_006925	COG5484	DNA packaging
HCV84_007270	COG3119	arylsulfatase activity
HCV84_007275	COG0641	radical SAM
HCV84_007295	COG2200	EAL domain
HCV84_007310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HCV84_007325	COG2723	6-phospho-beta-galactosidase activity
HCV84_007335	COG2233	PERMEase
HCV84_007350	COG1393	Belongs to the ArsC family
HCV84_007355	COG4783	chaperone-mediated protein folding
HCV84_007365	COG0628	permease
HCV84_007370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCV84_007375	COG2716	regulation of RNA biosynthetic process
HCV84_007385	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HCV84_007395	COG2321	neutral zinc metallopeptidase
HCV84_007400	COG1444	tRNA N-acetyltransferase activity
HCV84_007405	COG0400	carboxylic ester hydrolase activity
HCV84_007420	COG1393	Belongs to the ArsC family
HCV84_007430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCV84_007435	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCV84_007435	COG0493	'glutamate synthase
HCV84_007445	COG5342	invasion associated locus B
HCV84_007450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HCV84_007455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCV84_007465	COG4810	utilization protein
HCV84_007555	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCV84_007575	COG2837	iron assimilation
HCV84_007585	COG4150	thiosulfate binding
HCV84_007590	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HCV84_007595	COG4208	sulfate ABC transporter
HCV84_007600	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HCV84_007610	COG4319	ketosteroid isomerase
HCV84_007645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCV84_007665	COG3530	Putative quorum-sensing-regulated virulence factor
HCV84_007670	COG0385	Bile acid
HCV84_007675	COG0583	DNA-binding transcription factor activity
HCV84_007705	COG3415	Transposase
HCV84_007710	COG3415	Transposase
HCV84_007725	COG2200	EAL domain
HCV84_007725	COG2199	diguanylate cyclase activity
HCV84_007730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCV84_007745	COG0667	Aldo Keto reductase
HCV84_007750	COG3961	Belongs to the TPP enzyme family
HCV84_007765	COG3279	Response regulator of the LytR AlgR family
HCV84_007770	COG3275	phosphorelay sensor kinase activity
HCV84_007785	COG0436	Aminotransferase
HCV84_007795	COG2807	transmembrane transport
HCV84_007800	COG0590	tRNA wobble adenosine to inosine editing
HCV84_007805	COG0583	DNA-binding transcription factor activity
HCV84_007825	COG2116	formate transmembrane transporter activity
HCV84_007830	COG2853	Lipoprotein
HCV84_007840	COG3691	Protein conserved in bacteria
HCV84_007855	COG2062	phosphohistidine phosphatase, SixA
HCV84_007880	COG0730	response to heat
HCV84_007885	COG3101	peptidyl-lysine hydroxylation
HCV84_007900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCV84_007920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCV84_007930	COG0586	Pfam SNARE associated Golgi protein
HCV84_007940	COG0285	dihydrofolate synthase activity
HCV84_007945	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HCV84_007950	COG1286	toxin biosynthetic process
HCV84_007955	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HCV84_007960	COG0163	prenyltransferase activity
HCV84_007985	COG4160	amino acid transport
HCV84_007990	COG4598	ABC transporter
HCV84_008005	COG1090	epimerase
HCV84_008010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCV84_008015	COG0625	glutathione transferase activity
HCV84_008020	COG0625	glutathione transferase activity
HCV84_008025	COG0622	Phosphoesterase
HCV84_008030	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HCV84_008035	COG0857	belongs to the CobB CobQ family
HCV84_008035	COG0280	phosphate acetyltransferase
HCV84_008055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCV84_008060	COG0490	domain, Protein
HCV84_008060	COG0471	metal ion transport
HCV84_008070	COG0436	Aminotransferase
HCV84_008075	COG0583	DNA-binding transcription factor activity
HCV84_008120	COG0839	Belongs to the complex I subunit 6 family
HCV84_008130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCV84_008135	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCV84_008150	COG2153	protein acetylation
HCV84_008155	COG1169	isochorismate synthase
HCV84_008180	COG0318	PFAM AMP-dependent synthetase and ligase
HCV84_008190	COG5464	transposase or invertase
HCV84_008205	COG1414	Transcriptional regulator
HCV84_008215	COG2271	Major facilitator Superfamily
HCV84_008225	COG0247	lactate metabolic process
HCV84_008235	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HCV84_008240	COG2271	Major facilitator Superfamily
HCV84_008250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCV84_008275	COG0784	Response regulator, receiver
HCV84_008275	COG2205	protein histidine kinase activity
HCV84_008285	COG0642	Histidine kinase
HCV84_008285	COG2198	Histidine kinase
HCV84_008300	COG2169	Transcriptional regulator
HCV84_008300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCV84_008305	COG3145	DNA-N1-methyladenine dioxygenase activity
HCV84_008310	COG4615	Cyclic peptide transporter
HCV84_008315	COG2239	Acts as a magnesium transporter
HCV84_008320	COG0659	secondary active sulfate transmembrane transporter activity
HCV84_008335	COG0628	permease
HCV84_008360	COG1349	DNA-binding transcription factor activity
HCV84_008365	COG0494	nUDIX hydrolase
HCV84_008385	COG1061	Type III restriction enzyme res subunit
HCV84_008390	COG1187	pseudouridine synthase activity
HCV84_008395	COG2814	Major facilitator Superfamily
HCV84_008405	COG4172	Belongs to the ABC transporter superfamily
HCV84_008410	COG4239	(ABC) transporter, permease
HCV84_008415	COG4174	ABC transporter (Permease)
HCV84_008420	COG4166	transmembrane transport
HCV84_008425	COG2200	EAL domain
HCV84_008430	COG0791	NLP P60 protein
HCV84_008435	COG0671	phosphoesterase, PA-phosphatase related
HCV84_008440	COG0523	cobalamin synthesis protein
HCV84_008445	COG0246	Mannitol dehydrogenase
HCV84_008450	COG1312	Catalyzes the dehydration of D-mannonate
HCV84_008470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV84_008470	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV84_008475	COG1105	Belongs to the carbohydrate kinase PfkB family
HCV84_008480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV84_008480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV84_008480	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HCV84_008490	COG2855	membrane
HCV84_008495	COG0583	DNA-binding transcription factor activity
HCV84_008500	COG0833	amino acid
HCV84_008505	COG4771	TonB-dependent receptor
HCV84_008520	COG2311	Membrane
HCV84_008535	COG1129	ABC transporter
HCV84_008545	COG2949	membrane
HCV84_008555	COG1346	cytolysis
HCV84_008565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCV84_008570	COG3659	wide pore channel activity
HCV84_008585	COG2723	6-phospho-beta-galactosidase activity
HCV84_008590	COG2226	methyltransferase
HCV84_008595	COG1538	Outer membrane efflux protein
HCV84_008600	COG0586	Pfam SNARE associated Golgi protein
HCV84_008610	COG1686	Belongs to the peptidase S11 family
HCV84_008620	COG0277	FAD linked oxidase domain protein
HCV84_008625	COG1472	Belongs to the glycosyl hydrolase 3 family
HCV84_008630	COG1732	Glycine betaine
HCV84_008635	COG1174	glycine betaine transport
HCV84_008640	COG1125	glycine betaine transport
HCV84_008645	COG1174	glycine betaine transport
HCV84_008655	COG3275	phosphorelay sensor kinase activity
HCV84_008665	COG4807	Protein conserved in bacteria
HCV84_008685	COG5455	response to cobalt ion
HCV84_008690	COG0583	DNA-binding transcription factor activity
HCV84_008695	COG2252	PERMEase
HCV84_008705	COG0583	DNA-binding transcription factor activity
HCV84_008720	COG0351	phosphomethylpyrimidine kinase
HCV84_008725	COG1830	Aldolase
HCV84_008760	COG1070	Carbohydrate kinase
HCV84_008770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCV84_008775	COG4948	Mandelate Racemase Muconate Lactonizing
HCV84_008780	COG0747	negative chemotaxis
HCV84_008785	COG0601	transmembrane transport
HCV84_008790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCV84_008795	COG0444	Belongs to the ABC transporter superfamily
HCV84_008800	COG4608	Belongs to the ABC transporter superfamily
HCV84_008810	COG0826	peptidase U32
HCV84_008815	COG0745	RESPONSE REGULATOR receiver
HCV84_008820	COG2205	protein histidine kinase activity
HCV84_008845	COG1301	dicarboxylic acid transport
HCV84_008865	COG5002	protein histidine kinase activity
HCV84_008870	COG0443	Heat shock 70 kDa protein
HCV84_008875	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HCV84_008890	COG2982	Protein involved in outer membrane biogenesis
HCV84_008895	COG1253	flavin adenine dinucleotide binding
HCV84_009030	COG0438	transferase activity, transferring glycosyl groups
HCV84_009035	COG1215	transferase activity, transferring glycosyl groups
HCV84_009055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HCV84_009085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCV84_009090	COG0583	DNA-binding transcription factor activity
HCV84_009100	COG0531	amino acid
HCV84_009105	COG0640	Transcriptional regulator
HCV84_009110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCV84_009115	COG2925	Exonuclease
HCV84_009130	COG1289	transmembrane transporter activity
HCV84_009150	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HCV84_009160	COG1942	4-Oxalocrotonate Tautomerase
HCV84_009165	COG0583	DNA-binding transcription factor activity
HCV84_009170	COG0095	Lipoate-protein ligase
HCV84_009175	COG0477	Major facilitator Superfamily
HCV84_009185	COG3300	MHYT domain
HCV84_009185	COG5001	Diguanylate cyclase
HCV84_009190	COG3615	Tellurite resistance protein tehB
HCV84_009215	COG3706	GGDEF domain
HCV84_009230	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HCV84_009300	COG3504	Conjugal transfer protein
HCV84_009375	COG4771	TonB-dependent receptor
HCV84_009380	COG1021	2,3-dihydroxybenzoate-AMP ligase
HCV84_009400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCV84_009400	COG3433	isochorismatase activity
HCV84_009400	COG2226	methyltransferase
HCV84_009415	COG1132	(ABC) transporter
HCV84_009420	COG2814	Major facilitator Superfamily
HCV84_009425	COG1169	isochorismate synthase
HCV84_009430	COG0582	viral genome integration into host DNA
HCV84_009440	COG0534	Mate efflux family protein
HCV84_009450	COG0582	viral genome integration into host DNA
HCV84_009605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HCV84_009625	COG0604	alcohol dehydrogenase
HCV84_009630	COG1309	transcriptional regulator
HCV84_009635	COG0025	NhaP-type Na H and K H
HCV84_009730	COG4197	protein conserved in bacteria, prophage-related
HCV84_009745	COG1846	Transcriptional regulator
HCV84_009755	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HCV84_009760	COG1403	HNH endonuclease
HCV84_009950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCV84_009965	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HCV84_009975	COG1418	mRNA catabolic process
HCV84_009980	COG0270	DNA (cytosine-5-)-methyltransferase activity
HCV84_009985	COG3727	T/G mismatch-specific endonuclease activity
HCV84_009990	COG0697	spore germination
HCV84_009995	COG2354	Protein conserved in bacteria
HCV84_010025	COG0366	Alpha amylase catalytic
HCV84_010030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV84_010040	COG0765	amino acid transport
HCV84_010045	COG1126	abc transporter atp-binding protein
HCV84_010050	COG2197	response regulator
HCV84_010060	COG2197	response regulator
HCV84_010095	COG3318	Belongs to the UPF0149 family
HCV84_010095	COG3012	SEC-C Motif Domain Protein
HCV84_010100	COG0814	amino acid
HCV84_010110	COG1528	Iron-storage protein
HCV84_010125	COG0477	Major facilitator Superfamily
HCV84_010135	COG2211	Major facilitator Superfamily
HCV84_010145	COG1528	Iron-storage protein
HCV84_010155	COG1879	ABC-type sugar transport system periplasmic component
HCV84_010165	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV84_010190	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HCV84_010200	COG3102	Protein conserved in bacteria
HCV84_010220	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HCV84_010225	COG1801	Protein of unknown function DUF72
HCV84_010230	COG1335	isochorismatase
HCV84_010240	COG0494	nUDIX hydrolase
HCV84_010265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCV84_010275	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HCV84_010280	COG0739	heme binding
HCV84_010285	COG1560	Kdo2-lipid A biosynthetic process
HCV84_010295	COG1737	Transcriptional regulator
HCV84_010305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HCV84_010310	COG0129	dihydroxy-acid dehydratase activity
HCV84_010315	COG0800	Aldolase
HCV84_010325	COG3141	response to X-ray
HCV84_010330	COG2979	Protein of unknown function (DUF533)
HCV84_010335	COG1770	oligopeptidase
HCV84_010340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HCV84_010350	COG2372	response to copper ion
HCV84_010355	COG1276	copper resistance
HCV84_010370	COG2990	Protein conserved in bacteria
HCV84_010395	COG3008	intermembrane lipid transfer
HCV84_010400	COG2995	paraquat-inducible protein a
HCV84_010405	COG1956	GAF domain-containing protein
HCV84_010425	COG2814	Major facilitator Superfamily
HCV84_010430	COG1414	Transcriptional regulator
HCV84_010460	COG0768	penicillin binding
HCV84_010465	COG2226	methyltransferase
HCV84_010480	COG3716	PTS system mannose fructose sorbose family IID component
HCV84_010485	COG3715	PTS system
HCV84_010490	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV84_010490	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV84_010495	COG1253	flavin adenine dinucleotide binding
HCV84_010500	COG2200	EAL domain
HCV84_010505	COG1760	l-serine dehydratase
HCV84_010525	COG0251	oxidation-reduction process
HCV84_010530	COG1199	ATP-dependent helicase activity
HCV84_010540	COG3065	identical protein binding
HCV84_010550	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HCV84_010560	COG2894	cell division
HCV84_010575	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCV84_010605	COG2719	SpoVR family
HCV84_010630	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCV84_010640	COG4774	siderophore transport
HCV84_010655	COG2308	Evidence 4 Homologs of previously reported genes of
HCV84_010700	COG0583	DNA-binding transcription factor activity
HCV84_010705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCV84_010720	COG1882	Formate acetyltransferase
HCV84_010755	COG0583	DNA-binding transcription factor activity
HCV84_010785	COG0583	DNA-binding transcription factor activity
HCV84_010800	COG3122	Protein conserved in bacteria
HCV84_010820	COG2885	chlorophyll binding
HCV84_010850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCV84_010930	COG0012	GTP binding
HCV84_010950	COG0659	secondary active sulfate transmembrane transporter activity
HCV84_010980	COG2890	protein-(glutamine-N5) methyltransferase activity
HCV84_011000	COG0387	Pfam Sodium calcium exchanger
HCV84_011005	COG4572	Cation transport regulator
HCV84_011010	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HCV84_011020	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HCV84_011025	COG3707	response regulator
HCV84_011030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCV84_011040	COG1116	anion transmembrane transporter activity
HCV84_011045	COG2146	nitrite reductase [NAD(P)H] activity
HCV84_011045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCV84_011050	COG0243	molybdopterin cofactor binding
HCV84_011055	COG4932	domain protein
HCV84_011060	COG2197	response regulator
HCV84_011065	COG3850	Histidine kinase
HCV84_011070	COG2223	nitrite transmembrane transporter activity
HCV84_011080	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HCV84_011085	COG1140	nitrate reductase beta subunit
HCV84_011090	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HCV84_011095	COG2181	nitrate reductase activity
HCV84_011105	COG1522	sequence-specific DNA binding
HCV84_011140	COG0788	formyltetrahydrofolate deformylase activity
HCV84_011150	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCV84_011155	COG0745	RESPONSE REGULATOR receiver
HCV84_011160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCV84_011165	COG2916	Histone family protein nucleoid-structuring protein H-NS
HCV84_011175	COG1435	thymidine kinase activity
HCV84_011180	COG1454	alcohol dehydrogenase
HCV84_011180	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_011190	COG2095	MarC family integral membrane protein
HCV84_011195	COG4166	transmembrane transport
HCV84_011200	COG0601	transmembrane transport
HCV84_011205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCV84_011210	COG0444	Belongs to the ABC transporter superfamily
HCV84_011220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCV84_011240	COG2353	YceI-like domain
HCV84_011250	COG2350	Protein conserved in bacteria
HCV84_011260	COG3001	Fructosamine kinase
HCV84_011270	COG1105	Belongs to the carbohydrate kinase PfkB family
HCV84_011275	COG3137	Salt-induced outer membrane protein
HCV84_011315	COG0072	phenylalanine-tRNA ligase activity
HCV84_011315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCV84_011335	COG0583	DNA-binding transcription factor activity
HCV84_011355	COG0386	Belongs to the glutathione peroxidase family
HCV84_011365	COG0791	NLP P60 protein
HCV84_011375	COG4256	Hemin uptake protein
HCV84_011380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HCV84_011395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCV84_011395	COG0574	Belongs to the PEP-utilizing enzyme family
HCV84_011405	COG0628	permease
HCV84_011410	COG0247	lactate metabolic process
HCV84_011410	COG0277	FAD linked oxidase domain protein
HCV84_011415	COG2050	protein possibly involved in aromatic compounds catabolism
HCV84_011420	COG2261	transglycosylase associated protein
HCV84_011445	COG1120	ATPase activity
HCV84_011450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV84_011460	COG0583	DNA-binding transcription factor activity
HCV84_011485	COG1304	FMN binding
HCV84_011490	COG1309	transcriptional regulator
HCV84_011510	COG0316	Belongs to the HesB IscA family
HCV84_011515	COG0719	Fe-S assembly protein
HCV84_011520	COG0396	ATPase activity
HCV84_011525	COG0719	Fe-S assembly protein
HCV84_011540	COG1376	ErfK ybiS ycfS ynhG family protein
HCV84_011570	COG1309	transcriptional regulator
HCV84_011575	COG1082	Xylose isomerase domain protein TIM barrel
HCV84_011575	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HCV84_011580	COG2271	Major facilitator Superfamily
HCV84_011585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCV84_011595	COG1120	ATPase activity
HCV84_011600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV84_011605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCV84_011610	COG1414	Transcriptional regulator
HCV84_011645	COG2814	Major facilitator Superfamily
HCV84_011665	COG0583	DNA-binding transcription factor activity
HCV84_011670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCV84_011690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCV84_011695	COG1116	anion transmembrane transporter activity
HCV84_011700	COG4774	siderophore transport
HCV84_011705	COG1120	ATPase activity
HCV84_011710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV84_011715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV84_011735	COG0765	amino acid transport
HCV84_011740	COG1126	abc transporter atp-binding protein
HCV84_011780	COG3383	formate dehydrogenase (NAD+) activity
HCV84_011785	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HCV84_011795	COG1175	transmembrane transport
HCV84_011825	COG1857	crispr-associated protein
HCV84_011835	COG1518	maintenance of DNA repeat elements
HCV84_011840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HCV84_011885	COG4133	protoheme IX ABC transporter activity
HCV84_011890	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCV84_011895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCV84_011910	COG1138	Cytochrome C-type biogenesis protein
HCV84_011915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCV84_011920	COG4235	cytochrome complex assembly
HCV84_011920	COG3088	subunit of a heme lyase
HCV84_011960	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_011970	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCV84_011980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HCV84_011990	COG0583	DNA-binding transcription factor activity
HCV84_012010	COG0277	FAD linked oxidase domain protein
HCV84_012015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCV84_012040	COG0402	S-adenosylhomocysteine deaminase activity
HCV84_012080	COG2200	EAL domain
HCV84_012095	COG2205	protein histidine kinase activity
HCV84_012100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV84_012120	COG2200	EAL domain
HCV84_012160	COG2814	Major facilitator Superfamily
HCV84_012165	COG1082	Xylose isomerase domain protein TIM barrel
HCV84_012175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV84_012205	COG4608	Belongs to the ABC transporter superfamily
HCV84_012210	COG0444	Belongs to the ABC transporter superfamily
HCV84_012235	COG0346	lactoylglutathione lyase activity
HCV84_012240	COG1349	DNA-binding transcription factor activity
HCV84_012275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HCV84_012295	COG0300	oxidoreductase activity
HCV84_012335	COG0307	riboflavin synthase, alpha
HCV84_012340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HCV84_012345	COG2814	Major facilitator Superfamily
HCV84_012350	COG0583	DNA-binding transcription factor activity
HCV84_012365	COG2814	Major facilitator Superfamily
HCV84_012380	COG0791	NLP P60 protein
HCV84_012385	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HCV84_012395	COG0346	lactoylglutathione lyase activity
HCV84_012400	COG1902	pentaerythritol trinitrate reductase activity
HCV84_012405	COG1309	transcriptional regulator
HCV84_012410	COG3313	Fe-S protein
HCV84_012415	COG4989	oxidoreductase activity
HCV84_012420	COG2032	superoxide dismutase activity
HCV84_012425	COG1289	transmembrane transporter activity
HCV84_012430	COG1566	PFAM secretion protein HlyD family protein
HCV84_012445	COG3706	GGDEF domain
HCV84_012460	COG3895	Periplasmic Protein
HCV84_012475	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HCV84_012480	COG0625	glutathione transferase activity
HCV84_012490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HCV84_012500	COG4659	FMN binding
HCV84_012535	COG2723	6-phospho-beta-galactosidase activity
HCV84_012545	COG0673	inositol 2-dehydrogenase activity
HCV84_012555	COG2814	Major facilitator Superfamily
HCV84_012575	COG3038	cytochrome b561
HCV84_012595	COG0583	DNA-binding transcription factor activity
HCV84_012600	COG3485	protocatechuate 3,4-dioxygenase
HCV84_012605	COG3485	protocatechuate 3,4-dioxygenase
HCV84_012610	COG5383	Protein conserved in bacteria
HCV84_012615	COG2272	Belongs to the type-B carboxylesterase lipase family
HCV84_012630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCV84_012635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCV84_012640	COG1275	C4-dicarboxylate transporter malic acid transport protein
HCV84_012645	COG0500	methyltransferase
HCV84_012655	COG0697	spore germination
HCV84_012660	COG2207	Transcriptional regulator
HCV84_012660	COG3708	Transcriptional regulator
HCV84_012665	COG3135	benzoate transporter
HCV84_012670	COG1396	sequence-specific DNA binding
HCV84_012680	COG0826	peptidase U32
HCV84_012700	COG1294	oxidase, subunit
HCV84_012705	COG1271	oxidase subunit
HCV84_012710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCV84_012715	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HCV84_012720	COG3842	ATPase activity
HCV84_012725	COG1176	ABC-type spermidine putrescine transport system, permease component I
HCV84_012730	COG1177	transmembrane transport
HCV84_012735	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_012770	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_012775	COG0747	negative chemotaxis
HCV84_012785	COG3238	Protein conserved in bacteria
HCV84_012790	COG1247	-acetyltransferase
HCV84_012800	COG2130	NADP-dependent
HCV84_012815	COG3691	Protein conserved in bacteria
HCV84_012820	COG1228	amidohydrolase
HCV84_012825	COG4772	TonB-dependent receptor
HCV84_012850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCV84_012855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCV84_012860	COG1473	amidohydrolase
HCV84_012865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCV84_012870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV84_012880	COG0765	amino acid transport
HCV84_012885	COG1126	abc transporter atp-binding protein
HCV84_012895	COG0625	glutathione transferase activity
HCV84_012915	COG2211	Major facilitator Superfamily
HCV84_012930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCV84_012935	COG3842	ATPase activity
HCV84_012940	COG1840	ABC-type Fe3 transport system, periplasmic component
HCV84_012945	COG1178	ABC-type Fe3 transport system permease component
HCV84_012950	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HCV84_012955	COG2181	nitrate reductase activity
HCV84_012960	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HCV84_012965	COG1140	nitrate reductase beta subunit
HCV84_012970	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HCV84_012990	COG1414	Transcriptional regulator
HCV84_012995	COG4948	Mandelate Racemase Muconate Lactonizing
HCV84_013000	COG4829	muconolactone delta-isomerase
HCV84_013005	COG3485	protocatechuate 3,4-dioxygenase
HCV84_013015	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HCV84_013040	COG0437	4 iron, 4 sulfur cluster binding
HCV84_013045	COG2864	formate dehydrogenase
HCV84_013060	COG2326	polyphosphate kinase activity
HCV84_013070	COG2814	Major facilitator Superfamily
HCV84_013080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCV84_013090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCV84_013100	COG0747	negative chemotaxis
HCV84_013105	COG1064	alcohol dehydrogenase
HCV84_013120	COG0488	(ABC) transporter
HCV84_013160	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_013165	COG3729	General stress protein
HCV84_013175	COG3685	Protein conserved in bacteria
HCV84_013185	COG0366	Alpha amylase catalytic
HCV84_013195	COG2323	membrane
HCV84_013205	COG3111	PFAM Bacterial OB fold (BOF) protein
HCV84_013215	COG1764	response to oxidative stress
HCV84_013240	COG3781	membrane
HCV84_013245	COG0243	molybdopterin cofactor binding
HCV84_013250	COG0583	DNA-binding transcription factor activity
HCV84_013255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV84_013280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV84_013285	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCV84_013290	COG2814	Major facilitator Superfamily
HCV84_013295	COG1285	pathogenesis
HCV84_013300	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HCV84_013320	COG0519	Catalyzes the synthesis of GMP from XMP
HCV84_013320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HCV84_013360	COG0596	Alpha beta hydrolase
HCV84_013370	COG2205	protein histidine kinase activity
HCV84_013385	COG0076	glutamate decarboxylase activity
HCV84_013390	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCV84_013395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCV84_013400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCV84_013405	COG1116	anion transmembrane transporter activity
HCV84_013410	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HCV84_013425	COG0673	inositol 2-dehydrogenase activity
HCV84_013435	COG1609	Transcriptional regulator
HCV84_013440	COG3706	GGDEF domain
HCV84_013445	COG0402	S-adenosylhomocysteine deaminase activity
HCV84_013450	COG1953	Uracil, thiamine, allantoin
HCV84_013485	COG0596	Alpha beta hydrolase
HCV84_013495	COG2207	Transcriptional regulator
HCV84_013510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCV84_013535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCV84_013580	COG0765	amino acid transport
HCV84_013590	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HCV84_013600	COG2070	2-Nitropropane dioxygenase
HCV84_013605	COG0583	DNA-binding transcription factor activity
HCV84_013615	COG1902	pentaerythritol trinitrate reductase activity
HCV84_013620	COG4529	Protein conserved in bacteria
HCV84_013625	COG0477	Major facilitator Superfamily
HCV84_013655	COG2223	nitrite transmembrane transporter activity
HCV84_013665	COG1609	Transcriptional regulator
HCV84_013670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV84_013680	COG3037	sugar-specific permease SgaT UlaA
HCV84_013685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCV84_013695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV84_013700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV84_013700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV84_013700	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HCV84_013715	COG0583	DNA-binding transcription factor activity
HCV84_013720	COG0583	DNA-binding transcription factor activity
HCV84_013725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCV84_013735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCV84_013750	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV84_013760	COG1609	Transcriptional regulator
HCV84_013790	COG1652	LysM domain
HCV84_013815	COG0456	acetyltransferase
HCV84_013815	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HCV84_013825	COG0667	Aldo Keto reductase
HCV84_013830	COG0667	Aldo Keto reductase
HCV84_013835	COG3386	PFAM SMP-30 Gluconolaconase
HCV84_013840	COG0667	Aldo Keto reductase
HCV84_013875	COG0251	oxidation-reduction process
HCV84_013880	COG0583	DNA-binding transcription factor activity
HCV84_013885	COG0626	cystathionine gamma-synthase activity
HCV84_013890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCV84_013895	COG0814	amino acid
HCV84_013900	COG0583	DNA-binding transcription factor activity
HCV84_013910	COG1294	oxidase, subunit
HCV84_013915	COG1271	oxidase subunit
HCV84_013925	COG3118	belongs to the thioredoxin family
HCV84_013955	COG0583	DNA-binding transcription factor activity
HCV84_013995	COG1929	Belongs to the glycerate kinase type-1 family
HCV84_014000	COG3835	regulator
HCV84_014010	COG0583	DNA-binding transcription factor activity
HCV84_014020	COG2186	Transcriptional regulator
HCV84_014025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV84_014025	COG1263	PTS System
HCV84_014035	COG2814	Major facilitator Superfamily
HCV84_014040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV84_014040	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV84_014055	COG2819	hydrolase of the alpha beta superfamily
HCV84_014060	COG5001	Diguanylate cyclase
HCV84_014060	COG3300	MHYT domain
HCV84_014095	COG3188	usher protein
HCV84_014105	COG1649	PFAM Uncharacterised BCR, COG1649
HCV84_014110	COG3550	peptidyl-serine autophosphorylation
HCV84_014115	COG1396	sequence-specific DNA binding
HCV84_014120	COG2351	hydroxyisourate hydrolase activity
HCV84_014125	COG3195	allantoin biosynthetic process
HCV84_014125	COG3648	Uricase
HCV84_014130	COG2233	PERMEase
HCV84_014160	COG2207	Transcriptional regulator
HCV84_014175	COG4628	conserved protein (DUF2132)
HCV84_014195	COG2011	ABC-type metal ion transport system permease component
HCV84_014200	COG2070	2-Nitropropane dioxygenase
HCV84_014210	COG0477	Major facilitator Superfamily
HCV84_014275	COG2199	diguanylate cyclase activity
HCV84_014290	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_014295	COG0583	DNA-binding transcription factor activity
HCV84_014305	COG0039	L-malate dehydrogenase activity
HCV84_014310	COG1349	DNA-binding transcription factor activity
HCV84_014315	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HCV84_014320	COG3395	kinase activity
HCV84_014330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCV84_014335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCV84_014340	COG2271	Major facilitator Superfamily
HCV84_014370	COG4977	sequence-specific DNA binding
HCV84_014380	COG0697	spore germination
HCV84_014385	COG2814	Major facilitator Superfamily
HCV84_014415	COG0683	leucine binding
HCV84_014420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCV84_014455	COG2223	nitrite transmembrane transporter activity
HCV84_014460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCV84_014475	COG1349	DNA-binding transcription factor activity
HCV84_014480	COG2084	Dehydrogenase
HCV84_014485	COG3395	kinase activity
HCV84_014490	COG0235	Class ii aldolase
HCV84_014495	COG3622	Belongs to the hyi family
HCV84_014500	COG2610	gluconate transmembrane transporter activity
HCV84_014505	COG3708	Transcriptional regulator
HCV84_014505	COG2207	Transcriptional regulator
HCV84_014520	COG2200	EAL domain
HCV84_014525	COG1546	Belongs to the CinA family
HCV84_014530	COG0071	Belongs to the small heat shock protein (HSP20) family
HCV84_014550	COG2197	response regulator
HCV84_014565	COG2135	peptidase activity
HCV84_014570	COG2207	Transcriptional regulator
HCV84_014585	COG4221	oxidoreductase activity
HCV84_014590	COG1802	Transcriptional regulator
HCV84_014595	COG0589	response to stress
HCV84_014600	COG0246	Mannitol dehydrogenase
HCV84_014605	COG2271	Major facilitator Superfamily
HCV84_014620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCV84_014635	COG0243	molybdopterin cofactor binding
HCV84_014640	COG0437	4 iron, 4 sulfur cluster binding
HCV84_014645	COG3302	dmso reductase anchor subunit
HCV84_014660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HCV84_014665	COG1940	carbohydrate kinase activity
HCV84_014670	COG0583	DNA-binding transcription factor activity
HCV84_014675	COG2814	Major facilitator Superfamily
HCV84_014680	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HCV84_014690	COG3591	Belongs to the peptidase S1B family
HCV84_014710	COG0628	permease
HCV84_014740	COG0679	Auxin Efflux Carrier
HCV84_014750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCV84_014775	COG3290	protein histidine kinase activity
HCV84_014780	COG4565	transcriptional regulatory protein
HCV84_014800	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HCV84_014800	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HCV84_014810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCV84_014815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCV84_014825	COG0183	Belongs to the thiolase family
HCV84_014830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HCV84_014840	COG1414	Transcriptional regulator
HCV84_014845	COG2840	Smr protein MutS2
HCV84_014850	COG0583	DNA-binding transcription factor activity
HCV84_014860	COG1473	amidohydrolase
HCV84_014865	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HCV84_014880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCV84_014895	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HCV84_014900	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HCV84_014915	COG0531	amino acid
HCV84_014925	COG3136	membrane protein required for alginate biosynthesis
HCV84_014930	COG0745	RESPONSE REGULATOR receiver
HCV84_014940	COG2205	protein histidine kinase activity
HCV84_014950	COG0114	fumarate hydratase activity
HCV84_014955	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HCV84_014955	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HCV84_014960	COG1482	cell wall glycoprotein biosynthetic process
HCV84_014965	COG5339	Protein conserved in bacteria
HCV84_014970	COG1609	Transcriptional regulator
HCV84_014975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV84_014975	COG1263	PTS System
HCV84_014980	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HCV84_015005	COG2391	methyltransferase activity
HCV84_015010	COG0425	Belongs to the sulfur carrier protein TusA family
HCV84_015015	COG5562	phage envelope protein
HCV84_015020	COG0401	homolog of Blt101
HCV84_015025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCV84_015030	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_015040	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HCV84_015045	COG0477	Major facilitator Superfamily
HCV84_015050	COG1113	amino acid transport
HCV84_015055	COG2988	succinylglutamate desuccinylase activity
HCV84_015060	COG3724	N-succinylarginine dihydrolase activity
HCV84_015065	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_015070	COG3138	arginine N-succinyltransferase
HCV84_015075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCV84_015085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCV84_015090	COG0667	Aldo Keto reductase
HCV84_015095	COG0583	DNA-binding transcription factor activity
HCV84_015120	COG4122	O-methyltransferase activity
HCV84_015125	COG1643	Atp-dependent helicase
HCV84_015140	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCV84_015145	COG3327	negative regulation of DNA-templated transcription, initiation
HCV84_015150	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HCV84_015155	COG0183	Belongs to the thiolase family
HCV84_015160	COG2050	protein possibly involved in aromatic compounds catabolism
HCV84_015165	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCV84_015170	COG1024	Enoyl-CoA hydratase
HCV84_015175	COG1024	Enoyl-CoA hydratase
HCV84_015180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCV84_015185	COG2151	metal-sulfur cluster biosynthetic enzyme
HCV84_015190	COG3396	Phenylacetate-CoA oxygenase
HCV84_015195	COG3460	Phenylacetate-CoA oxygenase
HCV84_015200	COG3396	Phenylacetate-CoA oxygenase
HCV84_015205	COG2030	dehydratase
HCV84_015205	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_015225	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_015230	COG2207	Transcriptional regulator
HCV84_015235	COG3784	Protein of unknown function (DUF1318)
HCV84_015245	COG2911	Protein conserved in bacteria
HCV84_015250	COG0586	Pfam SNARE associated Golgi protein
HCV84_015255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCV84_015260	COG3187	Heat shock protein
HCV84_015265	COG3042	response to heat
HCV84_015270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCV84_015270	COG0674	pyruvate-flavodoxin oxidoreductase activity
HCV84_015270	COG1013	pyruvate-flavodoxin oxidoreductase activity
HCV84_015270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HCV84_015275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HCV84_015285	COG0589	response to stress
HCV84_015295	COG0513	Belongs to the DEAD box helicase family
HCV84_015305	COG1349	DNA-binding transcription factor activity
HCV84_015310	COG0673	inositol 2-dehydrogenase activity
HCV84_015325	COG1113	amino acid transport
HCV84_015330	COG1522	sequence-specific DNA binding
HCV84_015340	COG1448	Aminotransferase
HCV84_015345	COG2011	ABC-type metal ion transport system permease component
HCV84_015355	COG1464	Belongs to the NlpA lipoprotein family
HCV84_015360	COG0436	Aminotransferase
HCV84_015365	COG0604	alcohol dehydrogenase
HCV84_015395	COG0583	DNA-binding transcription factor activity
HCV84_015415	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_015420	COG1309	transcriptional regulator
HCV84_015425	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_015530	COG2885	chlorophyll binding
HCV84_015555	COG0693	protein deglycase activity
HCV84_015560	COG1078	dGTPase activity
HCV84_015565	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_015570	COG0583	DNA-binding transcription factor activity
HCV84_015630	COG2205	protein histidine kinase activity
HCV84_015630	COG5002	protein histidine kinase activity
HCV84_015630	COG0784	Response regulator, receiver
HCV84_015635	COG3250	beta-galactosidase activity
HCV84_015640	COG0656	L-ascorbic acid biosynthetic process
HCV84_015670	COG4166	transmembrane transport
HCV84_015680	COG2866	Carboxypeptidase
HCV84_015685	COG4948	Mandelate Racemase Muconate Lactonizing
HCV84_015690	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HCV84_015695	COG3180	Ammonia monooxygenase
HCV84_015710	COG0583	DNA-binding transcription factor activity
HCV84_015720	COG3106	COG3106 Predicted ATPase
HCV84_015730	COG1983	PspC domain protein
HCV84_015740	COG1842	Phage shock protein A
HCV84_015745	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HCV84_015755	COG1473	amidohydrolase
HCV84_015770	COG0702	epimerase
HCV84_015785	COG4171	peptide transport system, permease
HCV84_015800	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HCV84_015810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HCV84_015815	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCV84_015815	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCV84_015830	COG1349	DNA-binding transcription factor activity
HCV84_015840	COG0023	Translation Initiation Factor
HCV84_015850	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HCV84_015855	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HCV84_015860	COG0671	phosphoesterase, PA-phosphatase related
HCV84_015870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HCV84_015895	COG0616	signal peptide processing
HCV84_015905	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_015910	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HCV84_015940	COG0583	DNA-binding transcription factor activity
HCV84_015950	COG0009	L-threonylcarbamoyladenylate synthase
HCV84_015960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCV84_015965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCV84_015965	COG0512	Glutamine amidotransferase of anthranilate synthase
HCV84_015970	COG0134	indole-3-glycerol-phosphate synthase activity
HCV84_015970	COG0135	phosphoribosylanthranilate isomerase activity
HCV84_016035	COG3047	cAMP biosynthetic process
HCV84_016040	COG0727	PFAM Uncharacterised protein family (UPF0153)
HCV84_016070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCV84_016075	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_016080	COG1988	membrane-bound metal-dependent
HCV84_016085	COG1823	symporter activity
HCV84_016095	COG0753	catalase activity
HCV84_016105	COG1486	melibiose metabolic process
HCV84_016110	COG1917	Cupin 2, conserved barrel domain protein
HCV84_016110	COG2169	Transcriptional regulator
HCV84_016115	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCV84_016120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV84_016130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV84_016135	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCV84_016145	COG0322	excinuclease ABC activity
HCV84_016150	COG3678	ATP-independent chaperone mediated protein folding
HCV84_016160	COG3724	N-succinylarginine dihydrolase activity
HCV84_016170	COG3138	arginine N-succinyltransferase
HCV84_016180	COG0708	Exodeoxyribonuclease III
HCV84_016185	COG0398	Pfam SNARE associated Golgi protein
HCV84_016190	COG0398	Pfam SNARE associated Golgi protein
HCV84_016195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCV84_016200	COG4134	Bacterial extracellular solute-binding protein
HCV84_016205	COG4135	transport system, permease component
HCV84_016210	COG4136	ATPase activity
HCV84_016215	COG2897	thiosulfate sulfurtransferase activity
HCV84_016220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HCV84_016225	COG0494	nUDIX hydrolase
HCV84_016230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCV84_016235	COG3321	synthase
HCV84_016235	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_016235	COG0604	alcohol dehydrogenase
HCV84_016240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCV84_016245	COG0709	Synthesizes selenophosphate from selenide and ATP
HCV84_016255	COG0778	Nitroreductase
HCV84_016260	COG0616	signal peptide processing
HCV84_016265	COG0252	asparaginase activity
HCV84_016270	COG1335	isochorismatase
HCV84_016285	COG3139	Protein of unknown function (DUF1315)
HCV84_016305	COG0656	L-ascorbic acid biosynthetic process
HCV84_016310	COG3713	MltA-interacting MipA family protein
HCV84_016315	COG2766	serine protein kinase
HCV84_016330	COG0386	Belongs to the glutathione peroxidase family
HCV84_016355	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_016360	COG0583	DNA-binding transcription factor activity
HCV84_016365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCV84_016370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HCV84_016380	COG0859	PFAM glycosyl transferase family 9
HCV84_016385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HCV84_016395	COG2207	Transcriptional regulator
HCV84_016400	COG2807	transmembrane transport
HCV84_016405	COG0504	CTP synthase activity
HCV84_016410	COG1683	Conserved Protein
HCV84_016415	COG3189	MarR family transcriptional regulator
HCV84_016420	COG3042	response to heat
HCV84_016425	COG2203	Gaf domain
HCV84_016425	COG2199	diguanylate cyclase activity
HCV84_016445	COG3182	Iron-regulated membrane protein
HCV84_016455	COG1560	Kdo2-lipid A biosynthetic process
HCV84_016465	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HCV84_016470	COG3706	GGDEF domain
HCV84_016475	COG0583	DNA-binding transcription factor activity
HCV84_016480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCV84_016510	COG1294	oxidase, subunit
HCV84_016515	COG1271	oxidase subunit
HCV84_016520	COG3546	catalase activity
HCV84_016525	COG3685	Protein conserved in bacteria
HCV84_016530	COG3685	Protein conserved in bacteria
HCV84_016535	COG3729	General stress protein
HCV84_016540	COG1063	alcohol dehydrogenase
HCV84_016545	COG3813	Protein conserved in bacteria
HCV84_016565	COG0640	Transcriptional regulator
HCV84_016570	COG0538	isocitrate dehydrogenase activity
HCV84_016575	COG1187	pseudouridine synthase activity
HCV84_016595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCV84_016615	COG2205	protein histidine kinase activity
HCV84_016620	COG2850	peptidyl-arginine hydroxylation
HCV84_016640	COG1177	transmembrane transport
HCV84_016655	COG0318	PFAM AMP-dependent synthetase and ligase
HCV84_016660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HCV84_016665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCV84_016670	COG0698	ribose 5-phosphate isomerase
HCV84_016685	COG3395	kinase activity
HCV84_016700	COG2390	Transcriptional regulator
HCV84_016710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HCV84_016720	COG4591	ABC-type transport system involved in lipoprotein release permease component
HCV84_016730	COG4591	ABC-type transport system involved in lipoprotein release permease component
HCV84_016740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HCV84_016745	COG1376	ErfK ybiS ycfS ynhG family protein
HCV84_016745	COG1388	LysM domain
HCV84_016760	COG1309	transcriptional regulator
HCV84_016775	COG3134	Outer membrane lipoprotein
HCV84_016780	COG1252	NADH dehydrogenase
HCV84_016805	COG5633	Lipoprotein
HCV84_016810	COG0537	adenosine 5'-monophosphoramidase activity
HCV84_016820	COG0084	hydrolase, TatD family'
HCV84_016825	COG0470	DNA polymerase III
HCV84_016835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HCV84_016840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCV84_016845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCV84_016860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCV84_016880	COG1399	metal-binding, possibly nucleic acid-binding protein
HCV84_016900	COG1530	ribonuclease E activity
HCV84_016905	COG0583	DNA-binding transcription factor activity
HCV84_016910	COG2814	Major facilitator Superfamily
HCV84_016930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCV84_016975	COG1560	Kdo2-lipid A biosynthetic process
HCV84_016990	COG5645	(Lipo)protein
HCV84_017025	COG3381	protein complex oligomerization
HCV84_017050	COG0583	DNA-binding transcription factor activity
HCV84_017060	COG1335	isochorismatase
HCV84_017070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HCV84_017075	COG1702	phosphate starvation-inducible protein PhoH
HCV84_017095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCV84_017105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCV84_017120	COG1309	transcriptional regulator
HCV84_017155	COG2233	PERMEase
HCV84_017165	COG3729	General stress protein
HCV84_017195	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_017210	COG0531	amino acid
HCV84_017215	COG0174	glutamine synthetase
HCV84_017220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HCV84_017225	COG1396	sequence-specific DNA binding
HCV84_017225	COG1917	Cupin 2, conserved barrel domain protein
HCV84_017230	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_017235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCV84_017240	COG0583	DNA-binding transcription factor activity
HCV84_017245	COG0473	3-isopropylmalate dehydrogenase activity
HCV84_017250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HCV84_017255	COG4638	Rieske (2fe-2S)
HCV84_017260	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_017265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCV84_017270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV84_017270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV84_017270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCV84_017275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV84_017280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV84_017285	COG1882	Formate acetyltransferase
HCV84_017290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HCV84_017295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV84_017305	COG2207	Transcriptional regulator
HCV84_017310	COG3706	GGDEF domain
HCV84_017330	COG2200	EAL domain
HCV84_017340	COG0058	SHG alpha-glucan phosphorylase activity
HCV84_017355	COG0670	Belongs to the BI1 family
HCV84_017370	COG2207	Transcriptional regulator
HCV84_017375	COG1881	PFAM PEBP family protein
HCV84_017400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV84_017405	COG2274	protein secretion by the type I secretion system
HCV84_017420	COG1832	CoA-binding protein
HCV84_017430	COG0210	DNA helicase
HCV84_017435	COG3304	Inner membrane component domain
HCV84_017440	COG1289	transmembrane transporter activity
HCV84_017445	COG3070	regulator of competence-specific genes
HCV84_017465	COG1067	ATP-dependent peptidase activity
HCV84_017475	COG3130	regulation of translation
HCV84_017480	COG3009	Protein conserved in bacteria
HCV84_017485	COG3008	intermembrane lipid transfer
HCV84_017485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HCV84_017490	COG2995	paraquat-inducible protein a
HCV84_017495	COG0488	(ABC) transporter
HCV84_017505	COG0633	Ferredoxin
HCV84_017505	COG3217	Mosc domain protein beta barrel domain protein
HCV84_017520	COG0431	NADPH-dependent FMN reductase
HCV84_017525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCV84_017530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCV84_017535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCV84_017545	COG0308	aminopeptidase N
HCV84_017555	COG1473	amidohydrolase
HCV84_017565	COG0814	amino acid
HCV84_017585	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HCV84_017590	COG1448	Aminotransferase
HCV84_017595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCV84_017600	COG3108	Peptidase M15
HCV84_017605	COG2989	Protein conserved in bacteria
HCV84_017615	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HCV84_017625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCV84_017630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HCV84_017635	COG3173	Aminoglycoside phosphotransferase
HCV84_017650	COG3214	Protein conserved in bacteria
HCV84_017665	COG2333	competence protein COMEC
HCV84_017665	COG0658	competence protein
HCV84_017675	COG0539	negative regulation of cytoplasmic translation
HCV84_017695	COG2323	membrane
HCV84_017700	COG1944	ATP diphosphatase activity
HCV84_017705	COG2116	formate transmembrane transporter activity
HCV84_017710	COG1882	Formate acetyltransferase
HCV84_017715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HCV84_017720	COG0477	Major facilitator Superfamily
HCV84_017725	COG3302	dmso reductase anchor subunit
HCV84_017730	COG0437	4 iron, 4 sulfur cluster binding
HCV84_017735	COG0243	molybdopterin cofactor binding
HCV84_017745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HCV84_017755	COG1178	ABC-type Fe3 transport system permease component
HCV84_017755	COG1674	ftsk spoiiie
HCV84_017765	COG0492	ferredoxin-NADP+ reductase activity
HCV84_017770	COG4988	ABC transporter
HCV84_017775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HCV84_017790	COG0542	response to heat
HCV84_017800	COG1278	Cold shock
HCV84_017810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV84_017815	COG3593	DNA synthesis involved in DNA repair
HCV84_017825	COG2431	L-lysine efflux transmembrane transporter activity
HCV84_017835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCV84_017845	COG0028	Belongs to the TPP enzyme family
HCV84_017850	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HCV84_017855	COG0702	epimerase
HCV84_017860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCV84_017865	COG3023	N-Acetylmuramoyl-L-alanine amidase
HCV84_017870	COG3706	GGDEF domain
HCV84_017870	COG2203	Gaf domain
HCV84_017870	COG5001	Diguanylate cyclase
HCV84_017870	COG4251	negative regulation of phosphorylation
HCV84_017880	COG1126	abc transporter atp-binding protein
HCV84_017885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV84_017890	COG4215	(ABC) transporter
HCV84_017895	COG4160	amino acid transport
HCV84_017900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV84_017905	COG5002	protein histidine kinase activity
HCV84_017910	COG0745	RESPONSE REGULATOR receiver
HCV84_017925	COG1177	transmembrane transport
HCV84_017930	COG1176	ABC-type spermidine putrescine transport system, permease component I
HCV84_017935	COG3842	ATPase activity
HCV84_017940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HCV84_017955	COG0778	Nitroreductase
HCV84_017980	COG3226	Transcriptional regulator
HCV84_017985	COG0738	Major facilitator superfamily
HCV84_017990	COG0561	phosphatase activity
HCV84_017995	COG2814	Major facilitator Superfamily
HCV84_018000	COG0671	phosphoesterase, PA-phosphatase related
HCV84_018005	COG1349	DNA-binding transcription factor activity
HCV84_018010	COG1686	Belongs to the peptidase S11 family
HCV84_018020	COG0625	glutathione transferase activity
HCV84_018025	COG2133	pyrroloquinoline quinone binding
HCV84_018035	COG2223	nitrite transmembrane transporter activity
HCV84_018055	COG0747	negative chemotaxis
HCV84_018070	COG0303	'Molybdopterin
HCV84_018075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCV84_018080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HCV84_018085	COG1882	Formate acetyltransferase
HCV84_018090	COG0561	phosphatase activity
HCV84_018100	COG1609	Transcriptional regulator
HCV84_018105	COG2271	Major facilitator Superfamily
HCV84_018115	COG0488	(ABC) transporter
HCV84_018120	COG2365	Tyrosine phosphatase family
HCV84_018125	COG1376	ErfK ybiS ycfS ynhG family protein
HCV84_018130	COG2188	Transcriptional regulator
HCV84_018135	COG2723	6-phospho-beta-galactosidase activity
HCV84_018140	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCV84_018155	COG2194	sulfuric ester hydrolase activity
HCV84_018160	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HCV84_018175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV84_018180	COG0765	amino acid transport
HCV84_018185	COG1126	abc transporter atp-binding protein
HCV84_018190	COG0668	transmembrane transport
HCV84_018200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCV84_018210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCV84_018220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCV84_018225	COG1199	ATP-dependent helicase activity
HCV84_018230	COG0513	Belongs to the DEAD box helicase family
HCV84_018235	COG3958	Transketolase
HCV84_018240	COG3959	Transketolase, thiamine diphosphate binding domain
HCV84_018245	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_018250	COG2271	Major facilitator Superfamily
HCV84_018260	COG0583	DNA-binding transcription factor activity
HCV84_018265	COG1309	transcriptional regulator
HCV84_018270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV84_018275	COG1131	(ABC) transporter
HCV84_018280	COG0842	Transport permease protein
HCV84_018285	COG0842	Transport permease protein
HCV84_018295	COG3568	Endonuclease Exonuclease Phosphatase
HCV84_018300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCV84_018305	COG0392	lysyltransferase activity
HCV84_018310	COG0670	Belongs to the BI1 family
HCV84_018315	COG0314	molybdopterin synthase activity
HCV84_018320	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HCV84_018330	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCV84_018350	COG0745	RESPONSE REGULATOR receiver
HCV84_018355	COG0642	Histidine kinase
HCV84_018380	COG2226	methyltransferase
HCV84_018395	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCV84_018400	COG1881	PFAM PEBP family protein
HCV84_018440	COG4677	pectinesterase activity
HCV84_018450	COG0589	response to stress
HCV84_018455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV84_018490	COG0789	Transcriptional regulator
HCV84_018495	COG2200	EAL domain
HCV84_018520	COG0561	phosphatase activity
HCV84_018530	COG4149	molybdate abc transporter
HCV84_018535	COG0725	ABC transporter, periplasmic molybdate-binding protein
HCV84_018545	COG2005	Transcriptional regulator
HCV84_018545	COG3585	molybdate ion transport
HCV84_018550	COG1119	ATPase activity
HCV84_018560	COG1085	galactose-1-phosphate uridylyltransferase
HCV84_018570	COG2017	converts alpha-aldose to the beta-anomer
HCV84_018580	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HCV84_018595	COG3201	nicotinamide mononucleotide transporter
HCV84_018600	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HCV84_018645	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HCV84_018650	COG2885	chlorophyll binding
HCV84_018660	COG3064	Membrane
HCV84_018665	COG0848	biopolymer transport protein
HCV84_018670	COG0811	peptide transport
HCV84_018675	COG0824	Thioesterase
HCV84_018680	COG3790	cyd operon protein YbgE
HCV84_018685	COG4890	Cyd operon protein YbgT
HCV84_018690	COG1294	oxidase, subunit
HCV84_018695	COG1271	oxidase subunit
HCV84_018700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HCV84_018710	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCV84_018715	COG0567	Dehydrogenase, E1 component
HCV84_018720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCV84_018725	COG1053	succinate dehydrogenase
HCV84_018730	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HCV84_018735	COG2009	succinate dehydrogenase
HCV84_018770	COG1984	allophanate hydrolase subunit 2
HCV84_018775	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HCV84_018790	COG0415	Belongs to the DNA photolyase family
HCV84_018820	COG2205	protein histidine kinase activity
HCV84_018825	COG0745	RESPONSE REGULATOR receiver
HCV84_018835	COG0033	Phosphoglucomutase
HCV84_018845	COG0596	Alpha beta hydrolase
HCV84_018860	COG0735	belongs to the Fur family
HCV84_018900	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HCV84_018905	COG1940	carbohydrate kinase activity
HCV84_018905	COG1846	Transcriptional regulator
HCV84_018910	COG0647	UMP catabolic process
HCV84_018915	COG0367	asparagine synthase
HCV84_018955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCV84_018965	COG1702	phosphate starvation-inducible protein PhoH
HCV84_018990	COG0765	amino acid transport
HCV84_018995	COG0765	amino acid transport
HCV84_019000	COG1126	abc transporter atp-binding protein
HCV84_019015	COG2888	peptidyl-tyrosine sulfation
HCV84_019030	COG1466	dna polymerase III delta subunit
HCV84_019045	COG0799	negative regulation of ribosome biogenesis
HCV84_019055	COG0768	penicillin binding
HCV84_019060	COG0772	Belongs to the SEDS family
HCV84_019065	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCV84_019070	COG1686	Belongs to the peptidase S11 family
HCV84_019085	COG0583	DNA-binding transcription factor activity
HCV84_019095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCV84_019100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCV84_019120	COG3069	C4-dicarboxylate transmembrane transporter activity
HCV84_019125	COG3719	Belongs to the RNase T2 family
HCV84_019130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCV84_019150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HCV84_019155	COG0583	DNA-binding transcription factor activity
HCV84_019160	COG3969	phosphoadenosine phosphosulfate
HCV84_019165	COG1475	DNA binding
HCV84_019170	COG0436	Aminotransferase
HCV84_019195	COG1129	ABC transporter
HCV84_019200	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV84_019205	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV84_019215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCV84_019230	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HCV84_019240	COG0402	S-adenosylhomocysteine deaminase activity
HCV84_019250	COG0483	inositol monophosphate 1-phosphatase activity
HCV84_019255	COG2271	Major facilitator Superfamily
HCV84_019285	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV84_019290	COG1129	ABC transporter
HCV84_019295	COG0371	Dehydrogenase
HCV84_019300	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_019315	COG2879	small protein
HCV84_019320	COG1966	Carbon starvation protein
HCV84_019330	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_019335	COG3433	isochorismatase activity
HCV84_019335	COG1535	isochorismatase
HCV84_019340	COG1021	2,3-dihydroxybenzoate-AMP ligase
HCV84_019345	COG1169	isochorismate synthase
HCV84_019350	COG4592	Periplasmic binding protein
HCV84_019360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV84_019365	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV84_019370	COG1120	ATPase activity
HCV84_019375	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HCV84_019375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCV84_019380	COG3251	PFAM MbtH domain protein
HCV84_019385	COG2382	esterase
HCV84_019390	COG4771	TonB-dependent receptor
HCV84_019400	COG1879	ABC-type sugar transport system periplasmic component
HCV84_019410	COG1129	ABC transporter
HCV84_019415	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV84_019420	COG5464	transposase or invertase
HCV84_019425	COG2390	Transcriptional regulator
HCV84_019430	COG3959	Transketolase, thiamine diphosphate binding domain
HCV84_019435	COG3958	Transketolase
HCV84_019445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HCV84_019455	COG0583	DNA-binding transcription factor activity
HCV84_019460	COG0668	transmembrane transport
HCV84_019470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HCV84_019495	COG0747	negative chemotaxis
HCV84_019500	COG0601	transmembrane transport
HCV84_019505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCV84_019510	COG0444	Belongs to the ABC transporter superfamily
HCV84_019515	COG4608	Belongs to the ABC transporter superfamily
HCV84_019520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCV84_019525	COG4221	oxidoreductase activity
HCV84_019535	COG4215	(ABC) transporter
HCV84_019540	COG0765	amino acid transport
HCV84_019545	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HCV84_019560	COG0697	spore germination
HCV84_019575	COG4608	Belongs to the ABC transporter superfamily
HCV84_019580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCV84_019590	COG4166	transmembrane transport
HCV84_019600	COG3698	Phosphodiester glycosidase
HCV84_019655	COG0477	Major facilitator Superfamily
HCV84_019660	COG0668	transmembrane transport
HCV84_019665	COG1609	Transcriptional regulator
HCV84_019675	COG0673	inositol 2-dehydrogenase activity
HCV84_019685	COG2211	Major facilitator Superfamily
HCV84_019690	COG1113	amino acid transport
HCV84_019705	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_019710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCV84_019720	COG0531	amino acid
HCV84_019735	COG4680	protein conserved in bacteria
HCV84_019775	COG0667	Aldo Keto reductase
HCV84_019780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV84_019785	COG1473	amidohydrolase
HCV84_019815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV84_019820	COG1120	ATPase activity
HCV84_019825	COG1566	PFAM secretion protein HlyD family protein
HCV84_019870	COG4211	Belongs to the binding-protein-dependent transport system permease family
HCV84_019875	COG1129	ABC transporter
HCV84_019890	COG0673	inositol 2-dehydrogenase activity
HCV84_019920	COG3104	oligopeptide transport
HCV84_019925	COG1982	Orn Lys Arg decarboxylase major
HCV84_019930	COG0531	amino acid
HCV84_019935	COG3710	Transcriptional regulator
HCV84_019945	COG1560	Kdo2-lipid A biosynthetic process
HCV84_020360	COG2501	S4 domain
HCV84_020370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCV84_020385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCV84_020390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HCV84_020410	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HCV84_020415	COG4181	ATPase activity
HCV84_020420	COG2755	lipolytic protein G-D-S-L family
HCV84_020425	COG0300	oxidoreductase activity
HCV84_020430	COG3118	belongs to the thioredoxin family
HCV84_020435	COG0390	transport system, permease component
HCV84_020440	COG4619	ABC transporter
HCV84_020445	COG0330	HflC and HflK could
HCV84_020450	COG1585	Membrane protein implicated in regulation of membrane protease activity
HCV84_020465	COG3735	TraB family
HCV84_020470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HCV84_020480	COG2223	nitrite transmembrane transporter activity
HCV84_020485	COG4651	solute:proton antiporter activity
HCV84_020485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCV84_020490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV84_020530	COG2832	Protein of unknown function (DUF454)
HCV84_020535	COG3923	Primosomal replication protein n
HCV84_020545	COG5464	transposase or invertase
HCV84_020550	COG1196	nuclear chromosome segregation
HCV84_020550	COG3264	Mechanosensitive ion channel
HCV84_020560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV84_020565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCV84_020580	COG0110	maltose O-acetyltransferase activity
HCV84_020630	COG1874	Beta-galactosidase
HCV84_020635	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HCV84_020640	COG3833	ABC-type maltose transport systems, permease component
HCV84_020645	COG1175	transmembrane transport
HCV84_020650	COG2182	Extracellular solute-binding protein
HCV84_020660	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HCV84_020675	COG2364	Membrane
HCV84_020705	COG3695	enzyme binding
HCV84_020710	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HCV84_020715	COG1946	Acyl-CoA thioesterase
HCV84_020720	COG0004	ammonium transporteR
HCV84_020725	COG0347	Belongs to the P(II) protein family
HCV84_020730	COG1132	(ABC) transporter
HCV84_020735	COG1132	(ABC) transporter
HCV84_020740	COG1522	sequence-specific DNA binding
HCV84_020755	COG4533	DNA binding
HCV84_020765	COG0824	Thioesterase
HCV84_020770	COG1555	photosystem II stabilization
HCV84_020775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCV84_020780	COG0776	regulation of translation
HCV84_020785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HCV84_020805	COG0271	Belongs to the BolA IbaG family
HCV84_020810	COG3056	Lipoprotein
HCV84_020815	COG2223	nitrite transmembrane transporter activity
HCV84_020820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCV84_020825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCV84_020830	COG1845	cytochrome c oxidase, subunit III
HCV84_020835	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HCV84_020850	COG1414	Transcriptional regulator
HCV84_020855	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCV84_020860	COG1053	succinate dehydrogenase
HCV84_020870	COG1053	succinate dehydrogenase
HCV84_020885	COG0673	inositol 2-dehydrogenase activity
HCV84_020890	COG2814	Major facilitator Superfamily
HCV84_020900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCV84_020905	COG0693	protein deglycase activity
HCV84_020925	COG0142	geranyltranstransferase activity
HCV84_020935	COG0667	Aldo Keto reductase
HCV84_020940	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HCV84_020960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCV84_020960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCV84_020970	COG4238	major outer membrane lipoprotein
HCV84_020990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCV84_020995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCV84_021000	COG1862	Preprotein translocase
HCV84_021025	COG0450	alkyl hydroperoxide reductase
HCV84_021035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV84_021050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV84_021060	COG1228	amidohydrolase
HCV84_021070	COG1335	isochorismatase
HCV84_021075	COG0583	DNA-binding transcription factor activity
HCV84_021080	COG0366	Alpha amylase catalytic
HCV84_021105	COG0420	3'-5' exonuclease activity
HCV84_021110	COG0419	ATPase involved in DNA repair
HCV84_021115	COG1940	carbohydrate kinase activity
HCV84_021130	COG4126	flavin adenine dinucleotide binding
HCV84_021140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCV84_021145	COG3416	Protein conserved in bacteria
HCV84_021155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCV84_021165	COG1785	Belongs to the alkaline phosphatase family
HCV84_021205	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HCV84_021210	COG1335	isochorismatase
HCV84_021215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCV84_021220	COG0113	porphobilinogen synthase activity
HCV84_021225	COG1943	Transposase
HCV84_021235	COG2175	clavaminate synthase activity
HCV84_021240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCV84_021245	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HCV84_021250	COG4521	taurine ABC transporter
HCV84_021255	COG2040	homocysteine
HCV84_021260	COG0833	amino acid
HCV84_021275	COG4303	Ethanolamine ammonia lyase large subunit
HCV84_021280	COG4302	ethanolamine ammonia-lyase activity
HCV84_021320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV84_021325	COG1126	abc transporter atp-binding protein
HCV84_021330	COG4597	amino acid ABC transporter
HCV84_021335	COG0765	amino acid transport
HCV84_021350	COG3188	usher protein
HCV84_021375	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HCV84_021385	COG3639	organic phosphonate transmembrane transporter activity
HCV84_021400	COG0791	NLP P60 protein
HCV84_021425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCV84_021450	COG2909	trisaccharide binding
HCV84_021455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCV84_021460	COG0022	dehydrogenase e1 component
HCV84_021465	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCV84_021470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCV84_021490	COG1070	Carbohydrate kinase
HCV84_021495	COG1028	Short-chain dehydrogenase reductase Sdr
HCV84_021500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCV84_021505	COG3775	system Galactitol-specific IIC component
HCV84_021510	COG0625	glutathione transferase activity
HCV84_021515	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HCV84_021530	COG0579	oxidoreductase
HCV84_021535	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_021540	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCV84_021545	COG1113	amino acid transport
HCV84_021550	COG1802	Transcriptional regulator
HCV84_021570	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCV84_021575	COG0454	-acetyltransferase
HCV84_021590	COG2991	Protein conserved in bacteria
HCV84_021605	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HCV84_021610	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HCV84_021625	COG3034	peptidoglycan biosynthetic process
HCV84_021630	COG0121	glutamine amidotransferase
HCV84_021640	COG1960	acyl-CoA dehydrogenase activity
HCV84_021645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCV84_021655	COG0583	DNA-binding transcription factor activity
HCV84_021665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HCV84_021675	COG2226	methyltransferase
HCV84_021685	COG0741	lytic transglycosylase activity
HCV84_021685	COG1388	LysM domain
HCV84_021690	COG2226	methyltransferase
HCV84_021700	COG2814	Major facilitator Superfamily
HCV84_021705	COG0583	DNA-binding transcription factor activity
HCV84_021710	COG0656	L-ascorbic acid biosynthetic process
HCV84_021745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HCV84_021755	COG2011	ABC-type metal ion transport system permease component
HCV84_021760	COG1464	Belongs to the NlpA lipoprotein family
HCV84_021770	COG1720	tRNA m6t6A37 methyltransferase activity
HCV84_021780	COG0791	NLP P60 protein
HCV84_021785	COG3015	lipoprotein NlpE involved in copper resistance
HCV84_021790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HCV84_021805	COG4568	rho-dependent transcription termination
HCV84_021815	COG0346	lactoylglutathione lyase activity
HCV84_021820	COG1982	Orn Lys Arg decarboxylase major
HCV84_021830	COG0587	DNA-directed DNA polymerase activity
HCV84_021860	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HCV84_021870	COG0750	zinc metalloprotease
HCV84_021875	COG0575	Belongs to the CDS family
HCV84_021885	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HCV84_021910	COG0024	Methionine aminopeptidase
HCV84_021915	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HCV84_021930	COG3835	regulator
HCV84_021935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCV84_021955	COG2860	membrane
HCV84_021975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV84_021980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCV84_021985	COG1120	ATPase activity
HCV84_021990	COG4774	siderophore transport
HCV84_021995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCV84_022085	COG1643	Atp-dependent helicase
HCV84_022090	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HCV84_022110	COG0617	tRNA 3'-terminal CCA addition
HCV84_022115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HCV84_022135	COG0726	polysaccharide deacetylase
HCV84_022140	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV84_022145	COG0842	Transport permease protein
HCV84_022150	COG1131	(ABC) transporter
HCV84_022155	COG0288	reversible hydration of carbon dioxide
HCV84_022170	COG4993	Dehydrogenase
HCV84_022175	COG2132	Multicopper oxidase
HCV84_022220	COG3064	Membrane
HCV84_022235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCV84_022240	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCV84_022245	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HCV84_022250	COG2186	Transcriptional regulator
HCV84_022255	COG1113	amino acid transport
HCV84_022260	COG2211	Major facilitator Superfamily
HCV84_022265	COG3940	Belongs to the glycosyl hydrolase 43 family
HCV84_022270	COG3725	Membrane protein required for beta-lactamase induction
HCV84_022275	COG3023	N-Acetylmuramoyl-L-alanine amidase
HCV84_022285	COG4969	Belongs to the N-Me-Phe pilin family
HCV84_022290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HCV84_022295	COG1459	type II secretion system
HCV84_022320	COG0494	nUDIX hydrolase
HCV84_022340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCV84_022345	COG0849	cell division
HCV84_022370	COG0772	Belongs to the SEDS family
HCV84_022385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCV84_022390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCV84_022395	COG0768	penicillin binding
HCV84_022415	COG1609	Transcriptional regulator
HCV84_022425	COG0028	Belongs to the TPP enzyme family
HCV84_022470	COG0738	Major facilitator superfamily
HCV84_022480	COG0583	DNA-binding transcription factor activity
HCV84_022485	COG2271	Major facilitator Superfamily
HCV84_022490	COG2814	Major facilitator Superfamily
HCV84_022510	COG1178	ABC-type Fe3 transport system permease component
HCV84_022520	COG0586	Pfam SNARE associated Golgi protein
HCV84_022540	COG0235	Class ii aldolase
HCV84_022545	COG0417	DNA replication proofreading
HCV84_022555	COG0564	pseudouridine synthase activity
HCV84_022565	COG3493	citrate carrier protein
HCV84_022580	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HCV84_022585	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HCV84_022595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HCV84_022640	COG0505	Belongs to the CarA family
HCV84_022650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCV84_022660	COG3152	Membrane
HCV84_022675	COG1047	Peptidyl-prolyl cis-trans
HCV84_022690	COG0196	riboflavin kinase activity
HCV84_022700	COG0583	DNA-binding transcription factor activity
HCV84_022725	COG4735	regulation of single-species biofilm formation
HCV84_022730	COG1584	GPR1 FUN34 yaaH family protein
HCV84_022735	COG0477	Major facilitator Superfamily
HCV84_022740	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCV84_022745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCV84_022750	COG1115	amino acid carrier protein
HCV84_022765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HCV84_022775	COG0460	homoserine dehydrogenase
HCV84_022775	COG0527	aspartate kinase activity
HCV84_022795	COG0745	RESPONSE REGULATOR receiver
HCV84_022800	COG4452	Inner membrane protein CreD
HCV84_022805	COG2205	protein histidine kinase activity
HCV84_022810	COG0745	RESPONSE REGULATOR receiver
HCV84_022815	COG3045	CreA protein
HCV84_022820	COG3708	Transcriptional regulator
HCV84_022820	COG2207	Transcriptional regulator
HCV84_022840	COG0741	lytic transglycosylase activity
HCV84_022845	COG0488	(ABC) transporter
HCV84_022855	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HCV84_022860	COG0560	Phosphoserine phosphatase
HCV84_022865	COG3726	membrane protein affecting hemolysin expression
HCV84_022895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCV84_022900	COG0084	hydrolase, TatD family'
HCV84_022905	COG4667	esterase of the alpha-beta hydrolase superfamily
HCV84_022910	COG5487	UPF0391 membrane protein
HCV84_022915	COG2823	Periplasmic or secreted lipoprotein
HCV84_022925	COG1011	Hydrolase
HCV84_022930	COG0456	acetyltransferase
HCV84_022935	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HCV84_022970	COG3706	GGDEF domain
HCV84_022975	COG4114	ferric iron reductase
HCV84_022980	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV84_022980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV84_022985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HCV84_022990	COG2197	response regulator
HCV84_022995	COG2197	response regulator
HCV84_023010	COG2966	Psort location CytoplasmicMembrane, score
HCV84_023025	COG1484	DNA-dependent DNA replication
HCV84_023040	COG5464	transposase or invertase
HCV84_023050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCV84_023055	COG3716	PTS system mannose fructose sorbose family IID component
HCV84_023060	COG3715	PTS system
HCV84_023075	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HCV84_023075	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HCV84_023080	COG0456	acetyltransferase
HCV84_023080	COG1214	PFAM Peptidase M22, glycoprotease
HCV84_023090	COG1737	Transcriptional regulator
HCV84_023095	COG0800	Aldolase
HCV84_023100	COG3734	2-keto-3-deoxy-galactonokinase
HCV84_023115	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HCV84_023145	COG1846	Transcriptional regulator
HCV84_023155	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCV84_023165	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_023170	COG3384	dioxygenase
HCV84_023180	COG3971	2-oxopent-4-enoate hydratase activity
HCV84_023200	COG2368	4-hydroxyphenylacetate
HCV84_023205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCV84_023220	COG1966	Carbon starvation protein
HCV84_023225	COG2879	small protein
HCV84_023230	COG0523	cobalamin synthesis protein
HCV84_023240	COG1012	belongs to the aldehyde dehydrogenase family
HCV84_023245	COG5464	transposase or invertase
HCV84_023250	COG1917	Cupin 2, conserved barrel domain protein
HCV84_023250	COG2207	Transcriptional regulator
HCV84_023260	COG2733	membrane
HCV84_023275	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HCV84_023280	COG1924	4 iron, 4 sulfur cluster binding
HCV84_023295	COG1566	PFAM secretion protein HlyD family protein
HCV84_023305	COG5457	Domain of unknown function (DUF1127)
HCV84_023310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCV84_023320	COG0583	DNA-binding transcription factor activity
HCV84_023325	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCV84_023335	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV84_023340	COG1129	ABC transporter
HCV84_023345	COG1879	ABC-type sugar transport system periplasmic component
HCV84_023355	COG3706	GGDEF domain
HCV84_023360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV84_023365	COG1129	ABC transporter
HCV84_023365	COG0842	Transport permease protein
HCV84_023370	COG0842	Transport permease protein
HCV84_023400	COG2850	peptidyl-arginine hydroxylation
HCV84_023415	COG5002	protein histidine kinase activity
HCV84_023420	COG0745	RESPONSE REGULATOR receiver
HCV84_023425	COG1538	Outer membrane efflux protein
HCV84_023430	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV84_023435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV84_023440	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCV84_023450	COG3040	lipid binding
HCV84_023455	COG0789	Transcriptional regulator
HCV84_023460	COG3631	Ketosteroid isomerase-related protein
HCV84_023465	COG0300	oxidoreductase activity
HCV84_023480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HCV84_023500	COG3272	Protein of unknown function (DUF1722)
HCV84_023505	COG4580	involved in the transport of maltose and maltodextrins
HCV84_023510	COG2115	Belongs to the xylose isomerase family
HCV84_023515	COG2211	Major facilitator Superfamily
HCV84_023520	COG3507	Belongs to the glycosyl hydrolase 43 family
HCV84_023540	COG1216	Glycosyl transferase, family 2
HCV84_023590	COG1715	Restriction endonuclease
HCV84_023595	COG1196	nuclear chromosome segregation
HCV84_023615	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HCV84_023620	COG0582	viral genome integration into host DNA
HCV84_023690	COG0582	viral genome integration into host DNA
HCV84_023700	COG0288	reversible hydration of carbon dioxide
HCV84_023705	COG0659	secondary active sulfate transmembrane transporter activity
HCV84_023710	COG1064	alcohol dehydrogenase
HCV84_023715	COG1175	transmembrane transport
HCV84_023720	COG0395	ABC-type sugar transport system, permease component
HCV84_023725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HCV84_023730	COG3842	ATPase activity
HCV84_023745	COG1082	Xylose isomerase domain protein TIM barrel
HCV84_023755	COG3962	Belongs to the TPP enzyme family
HCV84_023760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV84_023765	COG0837	glucose binding
HCV84_023765	COG1737	Transcriptional regulator
HCV84_023770	COG3718	enzyme involved in inositol metabolism
HCV84_023785	COG0433	COG0433 Predicted ATPase
HCV84_023790	COG0795	lipopolysaccharide-transporting ATPase activity
HCV84_023795	COG0795	lipopolysaccharide-transporting ATPase activity
HCV84_023805	COG2927	DNA polymerase III (CHI subunit)
HCV84_023810	COG0525	valine-tRNA ligase activity
HCV84_023835	COG2731	YhcH YjgK YiaL family protein
HCV84_023870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV84_023870	COG1263	PTS System
HCV84_023875	COG0366	Alpha amylase catalytic
HCV84_023880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV84_023885	COG1486	melibiose metabolic process
HCV84_023910	COG0602	queuosine metabolic process
HCV84_023915	COG2026	Addiction module toxin, RelE StbE family
HCV84_023920	COG3077	Addiction module antitoxin, RelB DinJ family
HCV84_023925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV84_023925	COG3711	transcriptional antiterminator
HCV84_023930	COG2706	6-phosphogluconolactonase activity
HCV84_023945	COG3964	amidohydrolase
HCV84_023985	COG0312	modulator of DNA gyrase
HCV84_024010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HCV84_024020	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV84_024025	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV84_024030	COG1129	ABC transporter
HCV84_024035	COG1879	ABC-type sugar transport system periplasmic component
HCV84_024050	COG2105	PFAM AIG2 family protein
HCV84_024055	COG2911	Protein conserved in bacteria
HCV84_024060	COG0729	surface antigen
HCV84_024070	COG1253	flavin adenine dinucleotide binding
HCV84_024095	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HCV84_024110	COG1733	regulation of RNA biosynthetic process
HCV84_024115	COG0702	epimerase
HCV84_024125	COG0697	spore germination
HCV84_024135	COG1113	amino acid transport
HCV84_024140	COG0545	Peptidyl-prolyl cis-trans isomerase
HCV84_024145	COG3061	Opacity-associated protein A
HCV84_024155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HCV84_024160	COG2965	DNA replication, synthesis of RNA primer
HCV84_024220	COG1073	alpha beta
HCV84_024225	COG3650	response to hydrogen peroxide
HCV84_024235	COG1960	acyl-CoA dehydrogenase activity
HCV84_024240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCV84_024245	COG0557	exoribonuclease II activity
HCV84_024260	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HCV84_024270	COG0330	HflC and HflK could
HCV84_024275	COG0330	HflC and HflK could
HCV84_024280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCV84_024300	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCV84_024305	COG0802	atpase or kinase
HCV84_024310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HCV84_024310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HCV84_024315	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HCV84_024335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV84_024355	COG1511	domain protein
HCV84_024355	COG3264	Mechanosensitive ion channel
HCV84_024370	COG1053	succinate dehydrogenase
HCV84_024375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCV84_024395	COG2076	Multidrug Resistance protein
HCV84_024400	COG5510	response to toxic substance
HCV84_024415	COG1509	lysine 2,3-aminomutase activity
HCV84_024480	COG0531	amino acid
HCV84_024485	COG3030	protein affecting phage T7 exclusion by the F plasmid
HCV84_024490	COG1027	Aspartate ammonia-lyase
HCV84_024495	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HCV84_024510	COG1309	transcriptional regulator
HCV84_024540	COG0457	Tetratricopeptide repeat
HCV84_024545	COG1649	PFAM Uncharacterised BCR, COG1649
HCV84_024545	COG0726	polysaccharide deacetylase
HCV84_024550	COG1215	transferase activity, transferring glycosyl groups
HCV84_024565	COG0861	Integral membrane protein TerC family
HCV84_024605	COG1486	melibiose metabolic process
HCV84_024610	COG2169	Transcriptional regulator
HCV84_024620	COG2824	Alkylphosphonate utilization operon protein PhnA
HCV84_024625	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HCV84_024630	COG2188	Transcriptional regulator
HCV84_024635	COG3624	Phosphonate C-P lyase system protein PhnG
HCV84_024640	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HCV84_024645	COG3626	phosphonate metabolism
HCV84_024650	COG3627	carbon phosphorus lyase activity
HCV84_024655	COG4107	phosphonate C-P lyase system protein PhnK
HCV84_024660	COG4778	phosphonate C-P lyase system protein PhnL
HCV84_024665	COG3454	Phosphonate metabolism
HCV84_024675	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HCV84_024690	COG1129	ABC transporter
HCV84_024695	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV84_024730	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HCV84_024735	COG1301	dicarboxylic acid transport
HCV84_024745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCV84_024750	COG3162	membrane
HCV84_024780	COG3539	Fimbrial protein
HCV84_024785	COG1346	cytolysis
HCV84_024790	COG1380	Effector of murein hydrolase LrgA
HCV84_024795	COG0583	DNA-binding transcription factor activity
HCV84_024800	COG0025	NhaP-type Na H and K H
HCV84_024805	COG2252	PERMEase
HCV84_024810	COG0625	glutathione transferase activity
HCV84_024815	COG0789	Transcriptional regulator
HCV84_024825	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HCV84_024855	COG1234	tRNA 3'-trailer cleavage
HCV84_024860	COG1609	Transcriptional regulator
HCV84_024865	COG0483	inositol monophosphate 1-phosphatase activity
HCV84_024875	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCV84_024895	COG4771	TonB-dependent receptor
HCV84_024900	COG0741	lytic transglycosylase activity
HCV84_024915	COG2315	Protein conserved in bacteria
HCV84_024920	COG0432	Pfam Uncharacterised protein family UPF0047
HCV84_024935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCV84_024940	COG0305	Participates in initiation and elongation during chromosome replication
HCV84_024955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCV84_024965	COG0735	belongs to the Fur family
HCV84_024970	COG3237	CsbD-like
HCV84_024980	COG0534	Mate efflux family protein
HCV84_024990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HCV84_025060	COG0251	oxidation-reduction process
HCV84_025070	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HCV84_025080	COG0527	aspartate kinase activity
HCV84_025130	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HCV84_025140	COG0456	acetyltransferase
HCV84_025170	COG0151	Belongs to the GarS family
HCV84_025180	COG4191	Histidine kinase
HCV84_025185	COG3678	ATP-independent chaperone mediated protein folding
HCV84_025220	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HCV84_025235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCV84_025240	COG2104	thiamine diphosphate biosynthetic process
HCV84_025255	COG3706	GGDEF domain
HCV84_025265	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCV84_025270	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HCV84_025305	COG0250	Participates in transcription elongation, termination and antitermination
HCV84_025350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HCV84_025380	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HCV84_025390	COG1739	Uncharacterized protein family UPF0029
HCV84_025430	COG0805	protein transport
HCV84_025450	COG3165	ubiquinone biosynthetic process from chorismate
HCV84_025480	COG0583	DNA-binding transcription factor activity
HCV84_025485	COG0697	spore germination
HCV84_025490	COG0561	phosphatase activity
HCV84_025495	COG2267	carboxylic ester hydrolase activity
HCV84_025500	COG1280	lysine exporter protein (LysE YggA)
HCV84_025510	COG1280	lysine exporter protein (LysE YggA)
HCV84_025540	COG0210	DNA helicase
HCV84_025545	COG1011	Hydrolase
HCV84_025575	COG3072	Adenylate cyclase
HCV84_025590	COG2959	enzyme of heme biosynthesis
HCV84_025595	COG3071	HemY protein
HCV84_025640	COG2244	polysaccharide biosynthetic process
HCV84_025645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCV84_025650	COG0456	acetyltransferase
HCV84_025655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HCV84_025660	COG1088	dTDP-glucose 4,6-dehydratase activity
HCV84_025665	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HCV84_025670	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCV84_025680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCV84_025685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HCV84_025690	COG3118	belongs to the thioredoxin family
HCV84_025715	COG1811	Na channel or pump
HCV84_025725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCV84_025730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCV84_025740	COG0583	DNA-binding transcription factor activity
HCV84_025745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCV84_025760	COG3978	acetolactate synthase activity
HCV84_025780	COG3085	chromosome segregation
HCV84_025855	COG0583	DNA-binding transcription factor activity
HCV84_025870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HCV84_025885	COG3443	Belongs to the bacterial solute-binding protein 9 family
HCV84_025890	COG2207	Transcriptional regulator
HCV84_025900	COG0371	Dehydrogenase
HCV84_025905	COG0697	spore germination
HCV84_025915	COG0583	DNA-binding transcription factor activity
HCV84_025925	COG0737	Belongs to the 5'-nucleotidase family
HCV84_025935	COG0460	homoserine dehydrogenase
HCV84_025935	COG0527	aspartate kinase activity
HCV84_025940	COG0626	cystathionine gamma-synthase activity
HCV84_025955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCV84_025960	COG1609	Transcriptional regulator
HCV84_025965	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCV84_025980	COG1575	Belongs to the MenA family. Type 1 subfamily
HCV84_026000	COG3678	ATP-independent chaperone mediated protein folding
HCV84_026005	COG0745	RESPONSE REGULATOR receiver
HCV84_026010	COG2205	protein histidine kinase activity
HCV84_026015	COG2258	MOSC domain
HCV84_026020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCV84_026060	COG1129	ABC transporter
HCV84_026065	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV84_026070	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV84_026075	COG1454	alcohol dehydrogenase
HCV84_026085	COG2211	Major facilitator Superfamily
HCV84_026130	COG0437	4 iron, 4 sulfur cluster binding
HCV84_026135	COG2864	formate dehydrogenase
HCV84_026150	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HCV84_026160	COG0456	acetyltransferase
HCV84_026175	COG1011	Hydrolase
HCV84_026190	COG3852	Histidine kinase
HCV84_026205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCV84_026225	COG0204	Acyl-transferase
HCV84_026235	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCV84_026240	COG3084	Protein conserved in bacteria
HCV84_026250	COG1763	Mo-molybdopterin cofactor biosynthetic process
HCV84_026275	COG2186	Transcriptional regulator
HCV84_026280	COG0477	Major facilitator Superfamily
HCV84_026285	COG1609	Transcriptional regulator
HCV84_026290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV84_026300	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV84_026305	COG1129	ABC transporter
HCV84_026335	COG1522	sequence-specific DNA binding
HCV84_026340	COG0716	FMN binding
HCV84_026355	COG3312	ion transport
HCV84_026405	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCV84_026410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCV84_026415	COG0573	inorganic phosphate transmembrane transporter activity
HCV84_026420	COG0581	inorganic phosphate transmembrane transporter activity
HCV84_026425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCV84_026430	COG0704	Plays a role in the regulation of phosphate uptake
HCV84_026440	COG2382	esterase
HCV84_026445	COG0363	glucosamine-6-phosphate deaminase activity
HCV84_026450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCV84_026455	COG2252	PERMEase
HCV84_026460	COG0431	NADPH-dependent FMN reductase
HCV84_026465	COG2091	lysine biosynthetic process via aminoadipic acid
HCV84_026495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HCV84_026520	COG2203	Gaf domain
HCV84_026520	COG2199	diguanylate cyclase activity
HCV84_026525	COG5001	Diguanylate cyclase
HCV84_026525	COG1716	ATPase activity
HCV84_026540	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HCV84_026550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HCV84_026595	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV84_026625	COG0739	heme binding
HCV84_026635	COG2132	Multicopper oxidase
HCV84_026640	COG3667	copper resistance
HCV84_026645	COG2372	response to copper ion
HCV84_026650	COG1276	copper resistance
HCV84_026655	COG0745	RESPONSE REGULATOR receiver
HCV84_026660	COG2205	protein histidine kinase activity
HCV84_026680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HCV84_026695	COG0431	NADPH-dependent FMN reductase
HCV84_026725	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCV84_026790	COG2801	Transposase and inactivated derivatives
HCV84_026800	COG0501	Belongs to the peptidase M48B family
HCV84_026815	COG0542	response to heat
HCV84_026820	COG0071	Belongs to the small heat shock protein (HSP20) family
HCV84_026895	COG4172	Belongs to the ABC transporter superfamily
HCV84_026910	COG0601	transmembrane transport
HCV84_026915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCV84_026940	COG1595	DNA-templated transcription, initiation
HCV84_026945	COG3712	iron ion homeostasis
HCV84_026950	COG4772	TonB-dependent receptor
HCV84_026955	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HCV84_026960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV84_026965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV84_026970	COG1120	ATPase activity
HCV84_026975	COG3436	PFAM IS66 Orf2 family protein
HCV84_026995	COG1609	Transcriptional regulator
HCV84_027005	COG2223	nitrite transmembrane transporter activity
HCV84_027040	COG2801	Transposase and inactivated derivatives
HCV84_027095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCV84_027125	COG0431	NADPH-dependent FMN reductase
HCV84_027130	COG1393	Belongs to the ArsC family
HCV84_027135	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCV84_027145	COG0659	secondary active sulfate transmembrane transporter activity
HCV84_027150	COG0589	response to stress
HCV84_027160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCV84_027185	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCV84_027230	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCV84_027290	COG5499	transcription regulator containing HTH domain
HCV84_027355	COG1475	DNA binding
HCV84_027390	COG3344	reverse transcriptase
HCV84_027470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCV84_027535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCV84_027545	COG1702	phosphate starvation-inducible protein PhoH
HCV84_027685	COG3941	tape measure
HCV84_027775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCV84_027780	COG1475	DNA binding
HCV84_027785	COG1475	DNA binding
HCV84_027900	COG4735	regulation of single-species biofilm formation
HCV84_027935	COG0237	dephospho-CoA kinase activity
HCV84_027950	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HCV84_027960	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCV84_027965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCV84_028520	COG0489	protein tyrosine kinase activity
HCV84_028955	COG0629	single-stranded DNA binding
HCV84_028965	COG0741	lytic transglycosylase activity
HCV84_029125	COG4973	Belongs to the 'phage' integrase family. XerC subfamily