locus-tag	class	description
HCV85_000020	COG0187	DNA topoisomerase II activity
HCV85_000025	COG0561	phosphatase activity
HCV85_000040	COG2186	Transcriptional regulator
HCV85_000045	COG3734	2-keto-3-deoxy-galactonokinase
HCV85_000050	COG0800	Aldolase
HCV85_000060	COG2271	Major facilitator Superfamily
HCV85_000065	COG0823	Involved in the tonB-independent uptake of proteins
HCV85_000070	COG5645	(Lipo)protein
HCV85_000085	COG3645	SOS response
HCV85_000095	COG2188	Transcriptional regulator
HCV85_000110	COG2149	membrane
HCV85_000130	COG2610	gluconate transmembrane transporter activity
HCV85_000140	COG0583	DNA-binding transcription factor activity
HCV85_000145	COG2814	Major facilitator Superfamily
HCV85_000175	COG0028	Belongs to the TPP enzyme family
HCV85_000180	COG0440	acetolactate synthase activity
HCV85_000185	COG2197	response regulator
HCV85_000195	COG2271	Major facilitator Superfamily
HCV85_000235	COG2188	Transcriptional regulator
HCV85_000260	COG4580	involved in the transport of maltose and maltodextrins
HCV85_000265	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCV85_000270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV85_000270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV85_000280	COG1609	Transcriptional regulator
HCV85_000290	COG3384	dioxygenase
HCV85_000295	COG0583	DNA-binding transcription factor activity
HCV85_000300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCV85_000305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HCV85_000310	COG2828	Protein conserved in bacteria
HCV85_000325	COG0697	spore germination
HCV85_000330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV85_000330	COG1263	PTS System
HCV85_000340	COG2814	Major facilitator Superfamily
HCV85_000350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCV85_000385	COG0583	DNA-binding transcription factor activity
HCV85_000410	COG1464	Belongs to the NlpA lipoprotein family
HCV85_000425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HCV85_000435	COG1064	alcohol dehydrogenase
HCV85_000465	COG2211	Major facilitator Superfamily
HCV85_000470	COG1501	Belongs to the glycosyl hydrolase 31 family
HCV85_000480	COG1486	melibiose metabolic process
HCV85_000485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV85_000485	COG1263	PTS System
HCV85_000490	COG2982	Protein involved in outer membrane biogenesis
HCV85_000495	COG2233	PERMEase
HCV85_000500	COG0786	glutamate:sodium symporter activity
HCV85_000520	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HCV85_000545	COG3152	Membrane
HCV85_000555	COG1494	fructose-1,6-bisphosphatase
HCV85_000560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCV85_000565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCV85_000570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCV85_000590	COG2860	membrane
HCV85_000600	COG2169	Transcriptional regulator
HCV85_000600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCV85_000605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HCV85_000610	COG1561	YicC-like family, N-terminal region
HCV85_000635	COG1131	(ABC) transporter
HCV85_000640	COG0842	Transport permease protein
HCV85_000665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCV85_000700	COG1519	Transferase
HCV85_000705	COG1216	Glycosyl transferase, family 2
HCV85_000710	COG0438	transferase activity, transferring glycosyl groups
HCV85_000720	COG0859	PFAM glycosyl transferase family 9
HCV85_000745	COG0859	PFAM glycosyl transferase family 9
HCV85_000760	COG0156	8-amino-7-oxononanoate synthase activity
HCV85_000770	COG0463	Glycosyl transferase, family 2
HCV85_000775	COG2861	carbohydrate metabolic process
HCV85_000780	COG4942	peptidase
HCV85_000790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCV85_000795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCV85_000815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HCV85_000825	COG2186	Transcriptional regulator
HCV85_000845	COG3722	fumarate hydratase activity
HCV85_000865	COG1566	PFAM secretion protein HlyD family protein
HCV85_000870	COG0625	glutathione transferase activity
HCV85_000880	COG3276	selenocysteine insertion sequence binding
HCV85_000885	COG1414	Transcriptional regulator
HCV85_000890	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCV85_000895	COG3977	Valine--pyruvate aminotransferase
HCV85_000900	COG0366	Alpha amylase catalytic
HCV85_000905	COG2992	FlgJ-related protein
HCV85_000910	COG1609	Transcriptional regulator
HCV85_000910	COG2207	Transcriptional regulator
HCV85_000915	COG4214	carbohydrate transport
HCV85_000925	COG4213	ABC transporter substrate-binding protein
HCV85_000940	COG4682	membrane
HCV85_000945	COG4682	membrane
HCV85_000950	COG3274	enterobacterial common antigen metabolic process
HCV85_000985	COG1278	Cold shock
HCV85_000990	COG2944	sequence-specific DNA binding
HCV85_000995	COG2814	Major facilitator Superfamily
HCV85_001015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV85_001025	COG1609	Transcriptional regulator
HCV85_001030	COG2885	chlorophyll binding
HCV85_001035	COG0243	molybdopterin cofactor binding
HCV85_001040	COG0456	acetyltransferase
HCV85_001045	COG2818	Glycosylase
HCV85_001050	COG5571	outer membrane autotransporter
HCV85_001055	COG2223	nitrite transmembrane transporter activity
HCV85_001080	COG0747	negative chemotaxis
HCV85_001085	COG0601	transmembrane transport
HCV85_001090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCV85_001095	COG0444	Belongs to the ABC transporter superfamily
HCV85_001100	COG4608	Belongs to the ABC transporter superfamily
HCV85_001125	COG1215	transferase activity, transferring glycosyl groups
HCV85_001130	COG0457	Tetratricopeptide repeat
HCV85_001145	COG2194	sulfuric ester hydrolase activity
HCV85_001175	COG1215	transferase activity, transferring glycosyl groups
HCV85_001180	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HCV85_001185	COG0457	Tetratricopeptide repeat
HCV85_001185	COG3118	belongs to the thioredoxin family
HCV85_001190	COG2199	diguanylate cyclase activity
HCV85_001190	COG2200	EAL domain
HCV85_001200	COG0612	Peptidase, M16
HCV85_001210	COG2982	Protein involved in outer membrane biogenesis
HCV85_001215	COG0477	Major facilitator Superfamily
HCV85_001220	COG1295	ribonuclease BN
HCV85_001225	COG0583	DNA-binding transcription factor activity
HCV85_001230	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_001235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCV85_001245	COG1454	alcohol dehydrogenase
HCV85_001255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCV85_001260	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HCV85_001265	COG0671	phosphoesterase, PA-phosphatase related
HCV85_001285	COG0589	response to stress
HCV85_001295	COG0306	phosphate transporter
HCV85_001300	COG2081	HI0933 family
HCV85_001305	COG2239	Acts as a magnesium transporter
HCV85_001315	COG1124	(ABC) transporter
HCV85_001325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCV85_001330	COG0601	transmembrane transport
HCV85_001335	COG0747	negative chemotaxis
HCV85_001345	COG3479	Phenolic acid decarboxylase
HCV85_001385	COG0628	permease
HCV85_001390	COG0477	Major facilitator Superfamily
HCV85_001400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HCV85_001415	COG3714	YhhN family
HCV85_001425	COG3776	membrane
HCV85_001430	COG0742	ribosomal rna small subunit methyltransferase
HCV85_001435	COG0552	protein localization to endoplasmic reticulum
HCV85_001440	COG2884	Cell division ATP-binding protein ftsE
HCV85_001445	COG2177	Part of the ABC transporter FtsEX involved in
HCV85_001460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCV85_001470	COG0683	leucine binding
HCV85_001480	COG0683	leucine binding
HCV85_001485	COG0559	Belongs to the binding-protein-dependent transport system permease family
HCV85_001535	COG0584	glycerophosphoryl diester phosphodiesterase
HCV85_001545	COG0405	Gamma-glutamyltransferase
HCV85_001550	COG1247	-acetyltransferase
HCV85_001560	COG0673	inositol 2-dehydrogenase activity
HCV85_001565	COG1741	Belongs to the pirin family
HCV85_001570	COG1609	Transcriptional regulator
HCV85_001575	COG3265	gluconokinase activity
HCV85_001580	COG2610	gluconate transmembrane transporter activity
HCV85_001590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCV85_001615	COG0058	SHG alpha-glucan phosphorylase activity
HCV85_001630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HCV85_001645	COG1349	DNA-binding transcription factor activity
HCV85_001655	COG0058	SHG alpha-glucan phosphorylase activity
HCV85_001660	COG1640	4-alpha-glucanotransferase
HCV85_001665	COG2610	gluconate transmembrane transporter activity
HCV85_001675	COG1040	competence protein
HCV85_001700	COG1918	ferrous iron import across plasma membrane
HCV85_001705	COG2183	response to ionizing radiation
HCV85_001710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCV85_001735	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HCV85_001740	COG1011	Hydrolase
HCV85_001750	COG0494	nUDIX hydrolase
HCV85_001755	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HCV85_001780	COG4796	Type ii and iii secretion system protein
HCV85_001795	COG3266	domain, Protein
HCV85_001800	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HCV85_001805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCV85_001830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCV85_001835	COG0402	S-adenosylhomocysteine deaminase activity
HCV85_001840	COG0738	Major facilitator superfamily
HCV85_001865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCV85_001870	COG1289	transmembrane transporter activity
HCV85_001880	COG1765	OsmC-like protein
HCV85_001885	COG3954	Phosphoribulokinase
HCV85_001895	COG0429	hydrolase of the alpha beta-hydrolase fold
HCV85_001900	COG0488	(ABC) transporter
HCV85_001915	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HCV85_001920	COG1047	Peptidyl-prolyl cis-trans
HCV85_001930	COG0545	Peptidyl-prolyl cis-trans isomerase
HCV85_001935	COG2964	Protein conserved in bacteria
HCV85_001990	COG0051	transcription antitermination factor activity, RNA binding
HCV85_002015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HCV85_002030	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HCV85_002095	COG0201	protein transport
HCV85_002120	COG0202	RNA polymerase activity
HCV85_002135	COG0789	Transcriptional regulator
HCV85_002140	COG3036	rescue of stalled ribosome
HCV85_002170	COG0758	DNA mediated transformation
HCV85_002180	COG0551	DNA topoisomerase type I activity
HCV85_002200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCV85_002235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCV85_002240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV85_002245	COG1309	transcriptional regulator
HCV85_002250	COG0582	viral genome integration into host DNA
HCV85_002265	COG3561	AntA/AntB antirepressor
HCV85_002355	COG1802	Transcriptional regulator
HCV85_002355	COG4626	Terminase
HCV85_002380	COG4145	pantothenate transmembrane transporter activity
HCV85_002385	COG3924	membrane
HCV85_002390	COG0439	Biotin carboxylase
HCV85_002395	COG0511	ligase activity, forming carbon-carbon bonds
HCV85_002420	COG2200	EAL domain
HCV85_002420	COG2199	diguanylate cyclase activity
HCV85_002425	COG1077	Cell shape determining protein MreB Mrl
HCV85_002430	COG1792	Involved in formation and maintenance of cell shape
HCV85_002435	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HCV85_002445	COG1530	ribonuclease E activity
HCV85_002450	COG3164	Protein of unknown function
HCV85_002455	COG0312	modulator of DNA gyrase
HCV85_002460	COG0583	DNA-binding transcription factor activity
HCV85_002475	COG1289	transmembrane transporter activity
HCV85_002480	COG2732	(Barnase) inhibitor
HCV85_002505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCV85_002510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCV85_002515	COG3105	Protein conserved in bacteria
HCV85_002520	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HCV85_002540	COG0625	glutathione transferase activity
HCV85_002545	COG2969	positive regulation of protein catabolic process
HCV85_002555	COG0493	'glutamate synthase
HCV85_002560	COG0070	glutamate synthase
HCV85_002560	COG0067	glutamate synthase
HCV85_002560	COG0069	glutamate synthase activity
HCV85_002565	COG1242	4 iron, 4 sulfur cluster binding
HCV85_002570	COG2271	Major facilitator Superfamily
HCV85_002575	COG1063	alcohol dehydrogenase
HCV85_002580	COG1312	Catalyzes the dehydration of D-mannonate
HCV85_002585	COG0784	Response regulator, receiver
HCV85_002585	COG5002	protein histidine kinase activity
HCV85_002585	COG2198	Histidine kinase
HCV85_002590	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HCV85_002595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCV85_002600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_002610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_002615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCV85_002620	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HCV85_002625	COG1137	ATPase activity
HCV85_002630	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HCV85_002635	COG3117	lipopolysaccharide transmembrane transporter activity
HCV85_002640	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HCV85_002650	COG0530	calcium, potassium:sodium antiporter activity
HCV85_002655	COG1127	ABC transporter
HCV85_002660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HCV85_002665	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HCV85_002670	COG2854	intermembrane phospholipid transfer
HCV85_002675	COG3113	response to antibiotic
HCV85_002680	COG5007	Belongs to the BolA IbaG family
HCV85_002690	COG3423	Transcriptional regulator
HCV85_002695	COG0142	geranyltranstransferase activity
HCV85_002710	COG0697	spore germination
HCV85_002720	COG2027	D-alanyl-D-alanine carboxypeptidase
HCV85_002730	COG1534	Rna-binding protein
HCV85_002740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCV85_002745	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCV85_002755	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCV85_002795	COG0195	Participates in both transcription termination and antitermination
HCV85_002840	COG0814	amino acid
HCV85_002845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCV85_002850	COG0826	peptidase U32
HCV85_002855	COG0826	peptidase U32
HCV85_002860	COG3154	lipid carrier protein
HCV85_002865	COG3153	acetyltransferase
HCV85_002880	COG0693	protein deglycase activity
HCV85_002885	COG0702	epimerase
HCV85_002890	COG0701	Predicted permease
HCV85_002895	COG2823	Periplasmic or secreted lipoprotein
HCV85_002915	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HCV85_002930	COG1063	alcohol dehydrogenase
HCV85_002935	COG3775	system Galactitol-specific IIC component
HCV85_002940	COG3414	Phosphotransferase system galactitol-specific IIB component
HCV85_002945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_002955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_002955	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_002960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV85_002960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV85_002960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_002965	COG1105	Belongs to the carbohydrate kinase PfkB family
HCV85_002975	COG1349	DNA-binding transcription factor activity
HCV85_002980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV85_002985	COG2721	sulfolactate sulfo-lyase activity
HCV85_002990	COG2271	Major facilitator Superfamily
HCV85_003000	COG2084	Dehydrogenase
HCV85_003005	COG1929	Belongs to the glycerate kinase type-1 family
HCV85_003030	COG1741	Belongs to the pirin family
HCV85_003035	COG0583	DNA-binding transcription factor activity
HCV85_003040	COG3152	Membrane
HCV85_003045	COG0435	Glutathione S-transferase
HCV85_003050	COG2259	Doxx family
HCV85_003060	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HCV85_003065	COG4575	ribosome binding
HCV85_003070	COG1422	Protein of unknown function (DUF1090)
HCV85_003080	COG0586	Pfam SNARE associated Golgi protein
HCV85_003085	COG2186	Transcriptional regulator
HCV85_003090	COG2271	Major facilitator Superfamily
HCV85_003100	COG2721	sulfolactate sulfo-lyase activity
HCV85_003115	COG0861	Integral membrane protein TerC family
HCV85_003120	COG0673	inositol 2-dehydrogenase activity
HCV85_003125	COG1451	nucleotide metabolic process
HCV85_003145	COG1902	pentaerythritol trinitrate reductase activity
HCV85_003145	COG0446	pyridine nucleotide-disulphide oxidoreductase
HCV85_003195	COG1695	Transcriptional regulator
HCV85_003200	COG2375	cellular response to nickel ion
HCV85_003215	COG1461	Dihydroxyacetone kinase
HCV85_003220	COG2376	Dihydroxyacetone kinase
HCV85_003290	COG3247	response to pH
HCV85_003300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV85_003300	COG2198	Histidine kinase
HCV85_003300	COG2205	protein histidine kinase activity
HCV85_003300	COG0784	Response regulator, receiver
HCV85_003305	COG2197	response regulator
HCV85_003330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCV85_003335	COG0358	DNA primase activity
HCV85_003340	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCV85_003405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCV85_003420	COG4991	sh3 domain protein
HCV85_003425	COG3025	triphosphatase activity
HCV85_003450	COG2960	long-chain fatty acid transporting porin activity
HCV85_003465	COG3384	dioxygenase
HCV85_003470	COG0754	glutathionylspermidine amidase activity
HCV85_003485	COG0494	nUDIX hydrolase
HCV85_003490	COG3151	Protein conserved in bacteria
HCV85_003495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HCV85_003500	COG3150	esterase
HCV85_003510	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HCV85_003515	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCV85_003520	COG0642	Histidine kinase
HCV85_003530	COG3111	PFAM Bacterial OB fold (BOF) protein
HCV85_003535	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HCV85_003540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCV85_003545	COG0204	Acyl-transferase
HCV85_003550	COG2132	Multicopper oxidase
HCV85_003555	COG1032	radical SAM domain protein
HCV85_003565	COG0656	L-ascorbic acid biosynthetic process
HCV85_003570	COG1979	alcohol dehydrogenase
HCV85_003575	COG2207	Transcriptional regulator
HCV85_003580	COG0586	Pfam SNARE associated Golgi protein
HCV85_003585	COG0626	cystathionine gamma-synthase activity
HCV85_003595	COG0848	biopolymer transport protein
HCV85_003600	COG2211	Major facilitator Superfamily
HCV85_003625	COG0625	glutathione transferase activity
HCV85_003640	COG0754	glutathionylspermidine amidase activity
HCV85_003645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCV85_003665	COG0583	DNA-binding transcription factor activity
HCV85_003670	COG0626	cystathionine gamma-synthase activity
HCV85_003925	COG3423	Transcriptional regulator
HCV85_003935	COG1278	Cold shock
HCV85_003940	COG3423	Transcriptional regulator
HCV85_004005	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HCV85_004015	COG1811	Na channel or pump
HCV85_004020	COG1982	Orn Lys Arg decarboxylase major
HCV85_004025	COG2211	Major facilitator Superfamily
HCV85_004040	COG1194	a g-specific adenine glycosylase
HCV85_004050	COG3171	Protein conserved in bacteria
HCV85_004060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCV85_004075	COG0762	integral membrane protein
HCV85_004080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HCV85_004085	COG2805	Type II/IV secretion system protein
HCV85_004105	COG0189	ligase activity
HCV85_004110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HCV85_004115	COG2356	endonuclease I
HCV85_004125	COG2814	Major facilitator Superfamily
HCV85_004160	COG2146	nitrite reductase [NAD(P)H] activity
HCV85_004175	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_004180	COG1414	Transcriptional regulator
HCV85_004210	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_004215	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HCV85_004235	COG0501	Belongs to the peptidase M48B family
HCV85_004240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HCV85_004255	COG0191	fructose-bisphosphate aldolase activity
HCV85_004260	COG0668	transmembrane transport
HCV85_004270	COG2968	Membrane
HCV85_004285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCV85_004290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HCV85_004310	COG0006	proline dipeptidase activity
HCV85_004315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCV85_004320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCV85_004340	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_004345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCV85_004365	COG2723	6-phospho-beta-galactosidase activity
HCV85_004370	COG1737	Transcriptional regulator
HCV85_004380	COG1272	protein, Hemolysin III
HCV85_004390	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HCV85_004400	COG0716	FMN binding
HCV85_004405	COG4974	Belongs to the 'phage' integrase family
HCV85_004415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCV85_004435	COG4942	peptidase
HCV85_004445	COG2814	Major facilitator Superfamily
HCV85_004460	COG0667	Aldo Keto reductase
HCV85_004495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCV85_004500	COG1393	Belongs to the ArsC family
HCV85_004515	COG1538	Outer membrane efflux protein
HCV85_004520	COG1289	transmembrane transporter activity
HCV85_004535	COG3592	Divergent 4Fe-4S mono-cluster
HCV85_004540	COG2388	GCN5-related N-acetyl-transferase
HCV85_004550	COG3539	Fimbrial protein
HCV85_004555	COG3539	Fimbrial protein
HCV85_004560	COG3539	Fimbrial protein
HCV85_004565	COG3188	usher protein
HCV85_004570	COG3121	Chaperone
HCV85_004575	COG3539	Fimbrial protein
HCV85_004585	COG4974	Belongs to the 'phage' integrase family
HCV85_004590	COG0582	viral genome integration into host DNA
HCV85_004595	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HCV85_004600	COG1846	Transcriptional regulator
HCV85_004605	COG0697	spore germination
HCV85_004655	COG0667	Aldo Keto reductase
HCV85_004660	COG0814	amino acid
HCV85_004675	COG0183	Belongs to the thiolase family
HCV85_004685	COG0823	Involved in the tonB-independent uptake of proteins
HCV85_004690	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_004695	COG2814	Major facilitator Superfamily
HCV85_004730	COG3842	ATPase activity
HCV85_004735	COG0395	ABC-type sugar transport system, permease component
HCV85_004740	COG1175	transmembrane transport
HCV85_004745	COG1917	Cupin 2, conserved barrel domain protein
HCV85_004750	COG1794	racemase activity, acting on amino acids and derivatives
HCV85_004755	COG0583	DNA-binding transcription factor activity
HCV85_004765	COG1609	Transcriptional regulator
HCV85_004770	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV85_004775	COG2723	6-phospho-beta-galactosidase activity
HCV85_004780	COG2186	Transcriptional regulator
HCV85_004790	COG1609	Transcriptional regulator
HCV85_004810	COG0667	Aldo Keto reductase
HCV85_004820	COG0861	Integral membrane protein TerC family
HCV85_004855	COG2165	general secretion pathway protein
HCV85_004860	COG4795	General secretion pathway protein
HCV85_004870	COG4967	type IV pilus modification protein PilV
HCV85_004875	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HCV85_004880	COG1025	Belongs to the peptidase M16 family
HCV85_004885	COG1074	ATP-dependent DNA helicase activity
HCV85_004890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HCV85_004900	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HCV85_004900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HCV85_004905	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCV85_004910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCV85_004940	COG4656	Part of a membrane complex involved in electron transport
HCV85_004945	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_004945	COG1454	alcohol dehydrogenase
HCV85_004975	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HCV85_005145	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HCV85_005150	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HCV85_005155	COG2166	iron-sulfur cluster assembly
HCV85_005160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCV85_005170	COG0583	DNA-binding transcription factor activity
HCV85_005175	COG2363	Small membrane protein
HCV85_005185	COG1349	DNA-binding transcription factor activity
HCV85_005205	COG0738	Major facilitator superfamily
HCV85_005210	COG0235	Class ii aldolase
HCV85_005215	COG1454	alcohol dehydrogenase
HCV85_005235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCV85_005250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCV85_005255	COG2011	ABC-type metal ion transport system permease component
HCV85_005260	COG1464	Belongs to the NlpA lipoprotein family
HCV85_005265	COG0477	Major facilitator Superfamily
HCV85_005275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCV85_005280	COG1760	l-serine dehydratase
HCV85_005285	COG0814	amino acid
HCV85_005290	COG1611	Belongs to the LOG family
HCV85_005305	COG3098	single-species biofilm formation
HCV85_005310	COG0564	pseudouridine synthase activity
HCV85_005315	COG0716	FMN binding
HCV85_005320	COG2271	Major facilitator Superfamily
HCV85_005325	COG4948	Mandelate Racemase Muconate Lactonizing
HCV85_005330	COG4948	Mandelate Racemase Muconate Lactonizing
HCV85_005335	COG1929	Belongs to the glycerate kinase type-1 family
HCV85_005340	COG3437	response regulator, receiver
HCV85_005340	COG2205	protein histidine kinase activity
HCV85_005340	COG4999	Histidine kinase
HCV85_005340	COG3850	Histidine kinase
HCV85_005350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCV85_005355	COG3956	TIGRFAM MazG family protein
HCV85_005375	COG0602	queuosine metabolic process
HCV85_005380	COG0720	synthase
HCV85_005400	COG2234	aminopeptidase activity
HCV85_005460	COG4942	peptidase
HCV85_005460	COG1388	LysM domain
HCV85_005465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCV85_005490	COG0163	prenyltransferase activity
HCV85_005495	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCV85_005535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV85_005540	COG4558	Periplasmic binding protein
HCV85_005545	COG3720	iron ion transport
HCV85_005565	COG0679	Auxin Efflux Carrier
HCV85_005580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCV85_005585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCV85_005590	COG1121	(ABC) transporter
HCV85_005595	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCV85_005600	COG1609	Transcriptional regulator
HCV85_005605	COG1940	carbohydrate kinase activity
HCV85_005610	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCV85_005615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV85_005620	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV85_005625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV85_005630	COG4580	involved in the transport of maltose and maltodextrins
HCV85_005640	COG2723	6-phospho-beta-galactosidase activity
HCV85_005650	COG0309	Hydrogenase expression formation protein (HypE)
HCV85_005655	COG0409	Hydrogenase expression formation protein
HCV85_005660	COG0298	carbon dioxide binding
HCV85_005665	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HCV85_005680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCV85_005685	COG0651	ATP synthesis coupled electron transport
HCV85_005690	COG0650	Formate hydrogenlyase subunit 4
HCV85_005695	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HCV85_005695	COG3261	NADH dehydrogenase
HCV85_005700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCV85_005705	COG3260	NADH ubiquinone oxidoreductase 20
HCV85_005715	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HCV85_005725	COG2723	6-phospho-beta-galactosidase activity
HCV85_005730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV85_005730	COG1263	PTS System
HCV85_005735	COG1609	Transcriptional regulator
HCV85_005740	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCV85_005745	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HCV85_005750	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HCV85_005775	COG1349	DNA-binding transcription factor activity
HCV85_005780	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_005785	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_005795	COG3732	PTS system glucitol sorbitol-specific
HCV85_005800	COG3730	PTS system glucitol sorbitol-specific
HCV85_005805	COG2951	lytic endotransglycosylase activity
HCV85_005810	COG1121	(ABC) transporter
HCV85_005815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCV85_005825	COG1546	Belongs to the CinA family
HCV85_005845	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HCV85_005875	COG2823	Periplasmic or secreted lipoprotein
HCV85_005880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCV85_005885	COG1238	metal cluster binding
HCV85_005905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCV85_005910	COG2814	Major facilitator Superfamily
HCV85_005915	COG1566	PFAM secretion protein HlyD family protein
HCV85_005920	COG1846	Transcriptional regulator
HCV85_005930	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HCV85_005940	COG4176	ABC-type proline glycine betaine transport system permease component
HCV85_005955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCV85_005965	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCV85_005970	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCV85_005975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCV85_005980	COG4575	ribosome binding
HCV85_005995	COG2916	Histone family protein nucleoid-structuring protein H-NS
HCV85_006010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCV85_006015	COG0640	Transcriptional regulator
HCV85_006025	COG0583	DNA-binding transcription factor activity
HCV85_006030	COG3284	Transcriptional regulator
HCV85_006040	COG3539	Fimbrial protein
HCV85_006045	COG3121	Chaperone
HCV85_006065	COG3188	usher protein
HCV85_006075	COG3539	Fimbrial protein
HCV85_006080	COG2197	response regulator
HCV85_006095	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_006105	COG0235	Class ii aldolase
HCV85_006115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV85_006150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV85_006155	COG2207	Transcriptional regulator
HCV85_006155	COG3708	Transcriptional regulator
HCV85_006180	COG4974	Belongs to the 'phage' integrase family
HCV85_006215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCV85_006260	COG4695	Portal protein
HCV85_006425	COG2867	negative regulation of translational initiation
HCV85_006440	COG0497	DNA recombination
HCV85_006455	COG4536	flavin adenine dinucleotide binding
HCV85_006460	COG4137	Cytochrome C assembly protein
HCV85_006465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HCV85_006500	COG2885	chlorophyll binding
HCV85_006505	COG2199	diguanylate cyclase activity
HCV85_006515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HCV85_006520	COG1605	Chorismate mutase
HCV85_006520	COG0287	Prephenate dehydrogenase
HCV85_006530	COG1605	Chorismate mutase
HCV85_006530	COG0077	Prephenate dehydratase
HCV85_006540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCV85_006545	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCV85_006560	COG0542	response to heat
HCV85_006585	COG0477	Major facilitator Superfamily
HCV85_006590	COG5544	Lipoprotein
HCV85_006595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCV85_006605	COG3148	PFAM DTW domain containing protein
HCV85_006610	COG3118	belongs to the thioredoxin family
HCV85_006615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCV85_006630	COG0513	Belongs to the DEAD box helicase family
HCV85_006640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCV85_006655	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HCV85_006660	COG3026	antisigma factor binding
HCV85_006665	COG3086	response to oxidative stress
HCV85_006675	COG0681	Belongs to the peptidase S26 family
HCV85_006695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HCV85_006705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCV85_006710	COG1737	Transcriptional regulator
HCV85_006715	COG0560	Phosphoserine phosphatase
HCV85_006730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCV85_006730	COG0047	phosphoribosylformylglycinamidine synthase activity
HCV85_006735	COG2205	protein histidine kinase activity
HCV85_006740	COG3170	Tfp pilus assembly protein FimV
HCV85_006745	COG2204	response regulator
HCV85_006750	COG0347	Belongs to the P(II) protein family
HCV85_006755	COG1017	nitric oxide dioxygenase activity
HCV85_006755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCV85_006765	COG2259	Doxx family
HCV85_006770	COG1940	carbohydrate kinase activity
HCV85_006775	COG0457	Tetratricopeptide repeat
HCV85_006780	COG0477	Major facilitator Superfamily
HCV85_006780	COG2814	Major facilitator Superfamily
HCV85_006785	COG2017	converts alpha-aldose to the beta-anomer
HCV85_006790	COG2814	Major facilitator Superfamily
HCV85_006795	COG3711	transcriptional antiterminator
HCV85_006800	COG3683	transport system, periplasmic component
HCV85_006805	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HCV85_006835	COG0822	iron-sulfur transferase activity
HCV85_006855	COG0633	Ferredoxin
HCV85_006860	COG2975	iron-sulfur cluster assembly
HCV85_006880	COG2897	thiosulfate sulfurtransferase activity
HCV85_006885	COG2373	Large extracellular alpha-helical protein
HCV85_006890	COG4953	penicillin-binding protein 1C
HCV85_006920	COG2976	Protein conserved in bacteria
HCV85_006940	COG1645	bacterial-type flagellum-dependent swarming motility
HCV85_006950	COG0516	GMP reductase activity
HCV85_006950	COG0517	IMP dehydrogenase activity
HCV85_006995	COG3723	Recombinational DNA repair protein, rece pathway
HCV85_007095	COG3728	DNA packaging
HCV85_007095	COG5484	DNA packaging
HCV85_007195	COG3617	BRO family, N-terminal domain
HCV85_007240	COG3179	chitinase
HCV85_007250	COG3119	arylsulfatase activity
HCV85_007255	COG0641	radical SAM
HCV85_007275	COG2200	EAL domain
HCV85_007290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HCV85_007305	COG2723	6-phospho-beta-galactosidase activity
HCV85_007315	COG2233	PERMEase
HCV85_007330	COG1393	Belongs to the ArsC family
HCV85_007335	COG4783	chaperone-mediated protein folding
HCV85_007345	COG0628	permease
HCV85_007350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCV85_007355	COG2716	regulation of RNA biosynthetic process
HCV85_007365	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HCV85_007375	COG2321	neutral zinc metallopeptidase
HCV85_007380	COG1444	tRNA N-acetyltransferase activity
HCV85_007385	COG0400	carboxylic ester hydrolase activity
HCV85_007400	COG1393	Belongs to the ArsC family
HCV85_007410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCV85_007415	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCV85_007415	COG0493	'glutamate synthase
HCV85_007425	COG5342	invasion associated locus B
HCV85_007430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HCV85_007435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCV85_007445	COG4810	utilization protein
HCV85_007535	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCV85_007555	COG2837	iron assimilation
HCV85_007565	COG4150	thiosulfate binding
HCV85_007570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HCV85_007575	COG4208	sulfate ABC transporter
HCV85_007580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HCV85_007590	COG4319	ketosteroid isomerase
HCV85_007625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCV85_007645	COG3530	Putative quorum-sensing-regulated virulence factor
HCV85_007650	COG0385	Bile acid
HCV85_007655	COG0583	DNA-binding transcription factor activity
HCV85_007685	COG3415	Transposase
HCV85_007690	COG3415	Transposase
HCV85_007705	COG2200	EAL domain
HCV85_007705	COG2199	diguanylate cyclase activity
HCV85_007710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCV85_007725	COG0667	Aldo Keto reductase
HCV85_007730	COG3961	Belongs to the TPP enzyme family
HCV85_007745	COG3279	Response regulator of the LytR AlgR family
HCV85_007750	COG3275	phosphorelay sensor kinase activity
HCV85_007765	COG0436	Aminotransferase
HCV85_007775	COG2807	transmembrane transport
HCV85_007780	COG0590	tRNA wobble adenosine to inosine editing
HCV85_007785	COG0583	DNA-binding transcription factor activity
HCV85_007805	COG2116	formate transmembrane transporter activity
HCV85_007810	COG2853	Lipoprotein
HCV85_007820	COG3691	Protein conserved in bacteria
HCV85_007835	COG2062	phosphohistidine phosphatase, SixA
HCV85_007860	COG0730	response to heat
HCV85_007865	COG3101	peptidyl-lysine hydroxylation
HCV85_007880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCV85_007900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCV85_007910	COG0586	Pfam SNARE associated Golgi protein
HCV85_007920	COG0285	dihydrofolate synthase activity
HCV85_007925	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HCV85_007930	COG1286	toxin biosynthetic process
HCV85_007935	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HCV85_007940	COG0163	prenyltransferase activity
HCV85_007965	COG4160	amino acid transport
HCV85_007970	COG4598	ABC transporter
HCV85_007985	COG1090	epimerase
HCV85_007990	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCV85_007995	COG0625	glutathione transferase activity
HCV85_008000	COG0625	glutathione transferase activity
HCV85_008005	COG0622	Phosphoesterase
HCV85_008010	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HCV85_008015	COG0280	phosphate acetyltransferase
HCV85_008015	COG0857	belongs to the CobB CobQ family
HCV85_008035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCV85_008040	COG0471	metal ion transport
HCV85_008040	COG0490	domain, Protein
HCV85_008050	COG0436	Aminotransferase
HCV85_008055	COG0583	DNA-binding transcription factor activity
HCV85_008100	COG0839	Belongs to the complex I subunit 6 family
HCV85_008110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCV85_008115	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCV85_008130	COG2153	protein acetylation
HCV85_008135	COG1169	isochorismate synthase
HCV85_008160	COG0318	PFAM AMP-dependent synthetase and ligase
HCV85_008170	COG5464	transposase or invertase
HCV85_008185	COG1414	Transcriptional regulator
HCV85_008200	COG2271	Major facilitator Superfamily
HCV85_008210	COG0247	lactate metabolic process
HCV85_008220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HCV85_008225	COG2271	Major facilitator Superfamily
HCV85_008230	COG0584	glycerophosphoryl diester phosphodiesterase
HCV85_008235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCV85_008260	COG2205	protein histidine kinase activity
HCV85_008260	COG0784	Response regulator, receiver
HCV85_008270	COG2198	Histidine kinase
HCV85_008270	COG0642	Histidine kinase
HCV85_008285	COG2169	Transcriptional regulator
HCV85_008285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCV85_008290	COG3145	DNA-N1-methyladenine dioxygenase activity
HCV85_008295	COG4615	Cyclic peptide transporter
HCV85_008300	COG2239	Acts as a magnesium transporter
HCV85_008305	COG0659	secondary active sulfate transmembrane transporter activity
HCV85_008320	COG0628	permease
HCV85_008345	COG1349	DNA-binding transcription factor activity
HCV85_008350	COG0494	nUDIX hydrolase
HCV85_008370	COG1061	Type III restriction enzyme res subunit
HCV85_008375	COG1187	pseudouridine synthase activity
HCV85_008380	COG2814	Major facilitator Superfamily
HCV85_008390	COG4172	Belongs to the ABC transporter superfamily
HCV85_008395	COG4239	(ABC) transporter, permease
HCV85_008400	COG4174	ABC transporter (Permease)
HCV85_008405	COG4166	transmembrane transport
HCV85_008410	COG2200	EAL domain
HCV85_008415	COG0791	NLP P60 protein
HCV85_008420	COG0671	phosphoesterase, PA-phosphatase related
HCV85_008425	COG0523	cobalamin synthesis protein
HCV85_008430	COG0246	Mannitol dehydrogenase
HCV85_008435	COG1312	Catalyzes the dehydration of D-mannonate
HCV85_008460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_008460	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_008465	COG1105	Belongs to the carbohydrate kinase PfkB family
HCV85_008470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV85_008470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV85_008470	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HCV85_008480	COG2855	membrane
HCV85_008485	COG0583	DNA-binding transcription factor activity
HCV85_008490	COG0833	amino acid
HCV85_008495	COG4771	TonB-dependent receptor
HCV85_008510	COG2311	Membrane
HCV85_008525	COG1129	ABC transporter
HCV85_008535	COG2949	membrane
HCV85_008545	COG1346	cytolysis
HCV85_008555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCV85_008560	COG3659	wide pore channel activity
HCV85_008575	COG2723	6-phospho-beta-galactosidase activity
HCV85_008580	COG1538	Outer membrane efflux protein
HCV85_008585	COG0586	Pfam SNARE associated Golgi protein
HCV85_008595	COG1686	Belongs to the peptidase S11 family
HCV85_008605	COG0277	FAD linked oxidase domain protein
HCV85_008610	COG1472	Belongs to the glycosyl hydrolase 3 family
HCV85_008615	COG1732	Glycine betaine
HCV85_008620	COG1174	glycine betaine transport
HCV85_008625	COG1125	glycine betaine transport
HCV85_008630	COG1174	glycine betaine transport
HCV85_008640	COG3275	phosphorelay sensor kinase activity
HCV85_008650	COG4807	Protein conserved in bacteria
HCV85_008670	COG5455	response to cobalt ion
HCV85_008675	COG0583	DNA-binding transcription factor activity
HCV85_008680	COG2252	PERMEase
HCV85_008690	COG0583	DNA-binding transcription factor activity
HCV85_008705	COG0351	phosphomethylpyrimidine kinase
HCV85_008710	COG1830	Aldolase
HCV85_008720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HCV85_008745	COG1070	Carbohydrate kinase
HCV85_008755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCV85_008760	COG4948	Mandelate Racemase Muconate Lactonizing
HCV85_008765	COG0747	negative chemotaxis
HCV85_008770	COG0601	transmembrane transport
HCV85_008775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCV85_008780	COG0444	Belongs to the ABC transporter superfamily
HCV85_008785	COG4608	Belongs to the ABC transporter superfamily
HCV85_008795	COG0826	peptidase U32
HCV85_008800	COG0745	RESPONSE REGULATOR receiver
HCV85_008805	COG2205	protein histidine kinase activity
HCV85_008830	COG1301	dicarboxylic acid transport
HCV85_008850	COG5002	protein histidine kinase activity
HCV85_008855	COG0443	Heat shock 70 kDa protein
HCV85_008860	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HCV85_008875	COG2982	Protein involved in outer membrane biogenesis
HCV85_008880	COG1253	flavin adenine dinucleotide binding
HCV85_008920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCV85_008945	COG1088	dTDP-glucose 4,6-dehydratase activity
HCV85_008975	COG2244	polysaccharide biosynthetic process
HCV85_009030	COG0438	transferase activity, transferring glycosyl groups
HCV85_009035	COG1442	glycosyl transferase family 8
HCV85_009035	COG1216	Glycosyl transferase, family 2
HCV85_009045	COG0463	Glycosyl transferase, family 2
HCV85_009070	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HCV85_009100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCV85_009105	COG0583	DNA-binding transcription factor activity
HCV85_009115	COG0531	amino acid
HCV85_009120	COG0640	Transcriptional regulator
HCV85_009125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCV85_009135	COG2925	Exonuclease
HCV85_009145	COG3344	reverse transcriptase
HCV85_009195	COG3539	Fimbrial protein
HCV85_009200	COG3121	Chaperone
HCV85_009205	COG3188	usher protein
HCV85_009220	COG1560	Kdo2-lipid A biosynthetic process
HCV85_009230	COG3710	Transcriptional regulator
HCV85_009235	COG0531	amino acid
HCV85_009240	COG1982	Orn Lys Arg decarboxylase major
HCV85_009245	COG3104	oligopeptide transport
HCV85_009275	COG0673	inositol 2-dehydrogenase activity
HCV85_009290	COG1129	ABC transporter
HCV85_009295	COG4211	Belongs to the binding-protein-dependent transport system permease family
HCV85_009340	COG1566	PFAM secretion protein HlyD family protein
HCV85_009345	COG1120	ATPase activity
HCV85_009350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV85_009380	COG1473	amidohydrolase
HCV85_009385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV85_009390	COG0667	Aldo Keto reductase
HCV85_009435	COG0531	amino acid
HCV85_009445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCV85_009450	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_009465	COG1113	amino acid transport
HCV85_009470	COG2211	Major facilitator Superfamily
HCV85_009480	COG0673	inositol 2-dehydrogenase activity
HCV85_009490	COG2771	luxR family
HCV85_009505	COG3188	usher protein
HCV85_009535	COG0668	transmembrane transport
HCV85_009540	COG0477	Major facilitator Superfamily
HCV85_009555	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HCV85_009555	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HCV85_009560	COG2222	sugar isomerase
HCV85_009565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCV85_009570	COG3716	PTS system mannose fructose sorbose family IID component
HCV85_009580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV85_009590	COG0778	Nitroreductase
HCV85_009595	COG2315	Protein conserved in bacteria
HCV85_009640	COG3698	Phosphodiester glycosidase
HCV85_009650	COG0697	spore germination
HCV85_009665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HCV85_009670	COG0765	amino acid transport
HCV85_009675	COG4215	(ABC) transporter
HCV85_009685	COG4221	oxidoreductase activity
HCV85_009690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCV85_009695	COG4608	Belongs to the ABC transporter superfamily
HCV85_009700	COG0444	Belongs to the ABC transporter superfamily
HCV85_009705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCV85_009710	COG0601	transmembrane transport
HCV85_009715	COG0747	negative chemotaxis
HCV85_009740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HCV85_009750	COG0668	transmembrane transport
HCV85_009755	COG0583	DNA-binding transcription factor activity
HCV85_009765	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_009775	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV85_009780	COG1129	ABC transporter
HCV85_009790	COG1879	ABC-type sugar transport system periplasmic component
HCV85_009795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HCV85_009800	COG2390	Transcriptional regulator
HCV85_009805	COG3959	Transketolase, thiamine diphosphate binding domain
HCV85_009810	COG3958	Transketolase
HCV85_009815	COG2977	Belongs to the P-Pant transferase superfamily
HCV85_009820	COG4771	TonB-dependent receptor
HCV85_009825	COG2382	esterase
HCV85_009830	COG3251	PFAM MbtH domain protein
HCV85_009835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCV85_009835	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HCV85_009840	COG1120	ATPase activity
HCV85_009845	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV85_009850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV85_009860	COG4592	Periplasmic binding protein
HCV85_009865	COG1169	isochorismate synthase
HCV85_009870	COG1021	2,3-dihydroxybenzoate-AMP ligase
HCV85_009875	COG3433	isochorismatase activity
HCV85_009875	COG1535	isochorismatase
HCV85_009880	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_009890	COG1966	Carbon starvation protein
HCV85_009895	COG2879	small protein
HCV85_009910	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_009915	COG0371	Dehydrogenase
HCV85_009920	COG1129	ABC transporter
HCV85_009925	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV85_009955	COG2271	Major facilitator Superfamily
HCV85_009960	COG0483	inositol monophosphate 1-phosphatase activity
HCV85_009970	COG0402	S-adenosylhomocysteine deaminase activity
HCV85_009980	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HCV85_009995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCV85_010005	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV85_010010	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV85_010015	COG1129	ABC transporter
HCV85_010040	COG0436	Aminotransferase
HCV85_010045	COG1475	DNA binding
HCV85_010050	COG3969	phosphoadenosine phosphosulfate
HCV85_010055	COG0583	DNA-binding transcription factor activity
HCV85_010060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HCV85_010080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCV85_010085	COG3719	Belongs to the RNase T2 family
HCV85_010090	COG3069	C4-dicarboxylate transmembrane transporter activity
HCV85_010110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCV85_010125	COG0583	DNA-binding transcription factor activity
HCV85_010140	COG1686	Belongs to the peptidase S11 family
HCV85_010145	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCV85_010150	COG0772	Belongs to the SEDS family
HCV85_010155	COG0768	penicillin binding
HCV85_010165	COG0799	negative regulation of ribosome biogenesis
HCV85_010180	COG1466	dna polymerase III delta subunit
HCV85_010195	COG2888	peptidyl-tyrosine sulfation
HCV85_010210	COG1126	abc transporter atp-binding protein
HCV85_010215	COG0765	amino acid transport
HCV85_010220	COG0765	amino acid transport
HCV85_010235	COG4535	Mg2 and Co2 transporter CorC
HCV85_010245	COG1702	phosphate starvation-inducible protein PhoH
HCV85_010255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCV85_010295	COG0367	asparagine synthase
HCV85_010300	COG0647	UMP catabolic process
HCV85_010305	COG1940	carbohydrate kinase activity
HCV85_010305	COG1846	Transcriptional regulator
HCV85_010310	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HCV85_010350	COG0735	belongs to the Fur family
HCV85_010365	COG0596	Alpha beta hydrolase
HCV85_010375	COG0033	Phosphoglucomutase
HCV85_010385	COG0745	RESPONSE REGULATOR receiver
HCV85_010390	COG2205	protein histidine kinase activity
HCV85_010420	COG0415	Belongs to the DNA photolyase family
HCV85_010435	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HCV85_010440	COG1984	allophanate hydrolase subunit 2
HCV85_010475	COG2009	succinate dehydrogenase
HCV85_010480	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HCV85_010485	COG1053	succinate dehydrogenase
HCV85_010490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCV85_010495	COG0567	Dehydrogenase, E1 component
HCV85_010500	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCV85_010510	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HCV85_010515	COG1271	oxidase subunit
HCV85_010520	COG1294	oxidase, subunit
HCV85_010525	COG4890	Cyd operon protein YbgT
HCV85_010530	COG3790	cyd operon protein YbgE
HCV85_010535	COG0824	Thioesterase
HCV85_010540	COG0811	peptide transport
HCV85_010545	COG0848	biopolymer transport protein
HCV85_010550	COG3064	Membrane
HCV85_010560	COG2885	chlorophyll binding
HCV85_010565	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HCV85_010610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HCV85_010615	COG3201	nicotinamide mononucleotide transporter
HCV85_010630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HCV85_010640	COG2017	converts alpha-aldose to the beta-anomer
HCV85_010650	COG1085	galactose-1-phosphate uridylyltransferase
HCV85_010660	COG1119	ATPase activity
HCV85_010665	COG3585	molybdate ion transport
HCV85_010665	COG2005	Transcriptional regulator
HCV85_010675	COG0725	ABC transporter, periplasmic molybdate-binding protein
HCV85_010680	COG4149	molybdate abc transporter
HCV85_010685	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HCV85_010690	COG0561	phosphatase activity
HCV85_010715	COG2200	EAL domain
HCV85_010720	COG0789	Transcriptional regulator
HCV85_010755	COG4677	pectinesterase activity
HCV85_010795	COG1881	PFAM PEBP family protein
HCV85_010800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCV85_010815	COG2226	methyltransferase
HCV85_010840	COG0642	Histidine kinase
HCV85_010845	COG0745	RESPONSE REGULATOR receiver
HCV85_010865	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCV85_010875	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HCV85_010880	COG0314	molybdopterin synthase activity
HCV85_010885	COG0670	Belongs to the BI1 family
HCV85_010890	COG0392	lysyltransferase activity
HCV85_010895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCV85_010900	COG3568	Endonuclease Exonuclease Phosphatase
HCV85_010910	COG0842	Transport permease protein
HCV85_010915	COG0842	Transport permease protein
HCV85_010920	COG1131	(ABC) transporter
HCV85_010925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV85_010930	COG1309	transcriptional regulator
HCV85_010935	COG0583	DNA-binding transcription factor activity
HCV85_010945	COG2271	Major facilitator Superfamily
HCV85_010950	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_010955	COG3959	Transketolase, thiamine diphosphate binding domain
HCV85_010960	COG3958	Transketolase
HCV85_010965	COG0513	Belongs to the DEAD box helicase family
HCV85_010970	COG1199	ATP-dependent helicase activity
HCV85_010975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCV85_010985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCV85_010995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCV85_011005	COG0668	transmembrane transport
HCV85_011010	COG1126	abc transporter atp-binding protein
HCV85_011015	COG0765	amino acid transport
HCV85_011020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV85_011035	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HCV85_011040	COG2194	sulfuric ester hydrolase activity
HCV85_011050	COG1321	iron dependent repressor
HCV85_011055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCV85_011060	COG2723	6-phospho-beta-galactosidase activity
HCV85_011065	COG2188	Transcriptional regulator
HCV85_011070	COG1376	ErfK ybiS ycfS ynhG family protein
HCV85_011075	COG2365	Tyrosine phosphatase family
HCV85_011080	COG0488	(ABC) transporter
HCV85_011090	COG2271	Major facilitator Superfamily
HCV85_011095	COG1609	Transcriptional regulator
HCV85_011105	COG0561	phosphatase activity
HCV85_011110	COG1882	Formate acetyltransferase
HCV85_011115	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HCV85_011120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCV85_011125	COG0303	'Molybdopterin
HCV85_011140	COG0747	negative chemotaxis
HCV85_011160	COG2223	nitrite transmembrane transporter activity
HCV85_011170	COG2133	pyrroloquinoline quinone binding
HCV85_011175	COG0625	glutathione transferase activity
HCV85_011185	COG1686	Belongs to the peptidase S11 family
HCV85_011190	COG1349	DNA-binding transcription factor activity
HCV85_011195	COG0671	phosphoesterase, PA-phosphatase related
HCV85_011200	COG2814	Major facilitator Superfamily
HCV85_011205	COG0561	phosphatase activity
HCV85_011210	COG0738	Major facilitator superfamily
HCV85_011215	COG3226	Transcriptional regulator
HCV85_011220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HCV85_011225	COG3344	reverse transcriptase
HCV85_011265	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCV85_011300	COG4695	Portal protein
HCV85_011495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HCV85_011500	COG3842	ATPase activity
HCV85_011505	COG1176	ABC-type spermidine putrescine transport system, permease component I
HCV85_011510	COG1177	transmembrane transport
HCV85_011525	COG0745	RESPONSE REGULATOR receiver
HCV85_011530	COG5002	protein histidine kinase activity
HCV85_011535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV85_011540	COG4160	amino acid transport
HCV85_011545	COG4215	(ABC) transporter
HCV85_011550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV85_011555	COG1126	abc transporter atp-binding protein
HCV85_011565	COG4251	negative regulation of phosphorylation
HCV85_011565	COG5001	Diguanylate cyclase
HCV85_011565	COG2203	Gaf domain
HCV85_011565	COG3706	GGDEF domain
HCV85_011570	COG3023	N-Acetylmuramoyl-L-alanine amidase
HCV85_011575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCV85_011580	COG0702	epimerase
HCV85_011585	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HCV85_011590	COG0028	Belongs to the TPP enzyme family
HCV85_011600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCV85_011610	COG2431	L-lysine efflux transmembrane transporter activity
HCV85_011620	COG3593	DNA synthesis involved in DNA repair
HCV85_011625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV85_011635	COG1278	Cold shock
HCV85_011645	COG0542	response to heat
HCV85_011660	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HCV85_011665	COG4988	ABC transporter
HCV85_011670	COG0492	ferredoxin-NADP+ reductase activity
HCV85_011680	COG1178	ABC-type Fe3 transport system permease component
HCV85_011680	COG1674	ftsk spoiiie
HCV85_011690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HCV85_011700	COG0243	molybdopterin cofactor binding
HCV85_011705	COG0437	4 iron, 4 sulfur cluster binding
HCV85_011710	COG3302	dmso reductase anchor subunit
HCV85_011715	COG0477	Major facilitator Superfamily
HCV85_011720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HCV85_011725	COG1882	Formate acetyltransferase
HCV85_011730	COG2116	formate transmembrane transporter activity
HCV85_011735	COG1944	ATP diphosphatase activity
HCV85_011740	COG2323	membrane
HCV85_011760	COG0539	negative regulation of cytoplasmic translation
HCV85_011770	COG2333	competence protein COMEC
HCV85_011770	COG0658	competence protein
HCV85_011785	COG3214	Protein conserved in bacteria
HCV85_011800	COG3173	Aminoglycoside phosphotransferase
HCV85_011805	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HCV85_011810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCV85_011820	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HCV85_011830	COG2989	Protein conserved in bacteria
HCV85_011835	COG3108	Peptidase M15
HCV85_011840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCV85_011845	COG1448	Aminotransferase
HCV85_011870	COG0814	amino acid
HCV85_011880	COG1473	amidohydrolase
HCV85_011890	COG0308	aminopeptidase N
HCV85_011900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCV85_011905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCV85_011910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCV85_011915	COG0431	NADPH-dependent FMN reductase
HCV85_011930	COG3217	Mosc domain protein beta barrel domain protein
HCV85_011930	COG0633	Ferredoxin
HCV85_011940	COG0488	(ABC) transporter
HCV85_011945	COG2995	paraquat-inducible protein a
HCV85_011950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HCV85_011950	COG3008	intermembrane lipid transfer
HCV85_011955	COG3009	Protein conserved in bacteria
HCV85_011960	COG3130	regulation of translation
HCV85_011970	COG1067	ATP-dependent peptidase activity
HCV85_011990	COG3070	regulator of competence-specific genes
HCV85_011995	COG1289	transmembrane transporter activity
HCV85_012000	COG3304	Inner membrane component domain
HCV85_012005	COG0210	DNA helicase
HCV85_012015	COG1832	CoA-binding protein
HCV85_012030	COG1881	PFAM PEBP family protein
HCV85_012035	COG2207	Transcriptional regulator
HCV85_012050	COG0670	Belongs to the BI1 family
HCV85_012075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCV85_012080	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_012085	COG4638	Rieske (2fe-2S)
HCV85_012090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HCV85_012095	COG0473	3-isopropylmalate dehydrogenase activity
HCV85_012100	COG0583	DNA-binding transcription factor activity
HCV85_012105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCV85_012110	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_012115	COG1917	Cupin 2, conserved barrel domain protein
HCV85_012115	COG1396	sequence-specific DNA binding
HCV85_012120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HCV85_012125	COG0174	glutamine synthetase
HCV85_012130	COG0531	amino acid
HCV85_012145	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_012175	COG3729	General stress protein
HCV85_012185	COG2233	PERMEase
HCV85_012220	COG1309	transcriptional regulator
HCV85_012235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCV85_012245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCV85_012265	COG1702	phosphate starvation-inducible protein PhoH
HCV85_012270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HCV85_012280	COG1335	isochorismatase
HCV85_012290	COG0583	DNA-binding transcription factor activity
HCV85_012320	COG3381	protein complex oligomerization
HCV85_012355	COG5645	(Lipo)protein
HCV85_012370	COG1560	Kdo2-lipid A biosynthetic process
HCV85_012415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCV85_012435	COG2814	Major facilitator Superfamily
HCV85_012440	COG0583	DNA-binding transcription factor activity
HCV85_012445	COG1530	ribonuclease E activity
HCV85_012465	COG1399	metal-binding, possibly nucleic acid-binding protein
HCV85_012485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCV85_012500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCV85_012505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCV85_012510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HCV85_012520	COG0470	DNA polymerase III
HCV85_012525	COG0084	hydrolase, TatD family'
HCV85_012535	COG0537	adenosine 5'-monophosphoramidase activity
HCV85_012540	COG5633	Lipoprotein
HCV85_012565	COG1252	NADH dehydrogenase
HCV85_012570	COG3134	Outer membrane lipoprotein
HCV85_012585	COG1309	transcriptional regulator
HCV85_012600	COG1388	LysM domain
HCV85_012600	COG1376	ErfK ybiS ycfS ynhG family protein
HCV85_012605	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HCV85_012615	COG4591	ABC-type transport system involved in lipoprotein release permease component
HCV85_012625	COG4591	ABC-type transport system involved in lipoprotein release permease component
HCV85_012635	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HCV85_012645	COG0318	PFAM AMP-dependent synthetase and ligase
HCV85_012660	COG1177	transmembrane transport
HCV85_012680	COG2850	peptidyl-arginine hydroxylation
HCV85_012685	COG2205	protein histidine kinase activity
HCV85_012705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCV85_012725	COG1187	pseudouridine synthase activity
HCV85_012730	COG0538	isocitrate dehydrogenase activity
HCV85_012735	COG0640	Transcriptional regulator
HCV85_012755	COG3813	Protein conserved in bacteria
HCV85_012760	COG1063	alcohol dehydrogenase
HCV85_012765	COG3729	General stress protein
HCV85_012770	COG3685	Protein conserved in bacteria
HCV85_012775	COG3685	Protein conserved in bacteria
HCV85_012780	COG3546	catalase activity
HCV85_012785	COG1271	oxidase subunit
HCV85_012790	COG1294	oxidase, subunit
HCV85_012820	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCV85_012825	COG0583	DNA-binding transcription factor activity
HCV85_012830	COG3706	GGDEF domain
HCV85_012835	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HCV85_012845	COG1560	Kdo2-lipid A biosynthetic process
HCV85_012855	COG3182	Iron-regulated membrane protein
HCV85_012875	COG2203	Gaf domain
HCV85_012875	COG2199	diguanylate cyclase activity
HCV85_012880	COG3042	response to heat
HCV85_012885	COG3189	MarR family transcriptional regulator
HCV85_012890	COG1683	Conserved Protein
HCV85_012895	COG0504	CTP synthase activity
HCV85_012900	COG2807	transmembrane transport
HCV85_012905	COG2207	Transcriptional regulator
HCV85_012915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HCV85_012920	COG0859	PFAM glycosyl transferase family 9
HCV85_012930	COG3344	reverse transcriptase
HCV85_012935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HCV85_012940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCV85_012945	COG0583	DNA-binding transcription factor activity
HCV85_012950	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_012975	COG0386	Belongs to the glutathione peroxidase family
HCV85_012990	COG2766	serine protein kinase
HCV85_012995	COG3713	MltA-interacting MipA family protein
HCV85_013000	COG0656	L-ascorbic acid biosynthetic process
HCV85_013020	COG3139	Protein of unknown function (DUF1315)
HCV85_013035	COG1063	alcohol dehydrogenase
HCV85_013040	COG2271	Major facilitator Superfamily
HCV85_013045	COG1063	alcohol dehydrogenase
HCV85_013050	COG0191	fructose-bisphosphate aldolase activity
HCV85_013055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV85_013060	COG0667	Aldo Keto reductase
HCV85_013065	COG1349	DNA-binding transcription factor activity
HCV85_013070	COG2814	Major facilitator Superfamily
HCV85_013075	COG1335	isochorismatase
HCV85_013080	COG0252	asparaginase activity
HCV85_013085	COG0616	signal peptide processing
HCV85_013090	COG0778	Nitroreductase
HCV85_013105	COG0709	Synthesizes selenophosphate from selenide and ATP
HCV85_013110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCV85_013115	COG0604	alcohol dehydrogenase
HCV85_013115	COG3321	synthase
HCV85_013115	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_013120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCV85_013125	COG0494	nUDIX hydrolase
HCV85_013130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HCV85_013135	COG2897	thiosulfate sulfurtransferase activity
HCV85_013140	COG4136	ATPase activity
HCV85_013145	COG4135	transport system, permease component
HCV85_013150	COG4134	Bacterial extracellular solute-binding protein
HCV85_013155	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCV85_013160	COG0398	Pfam SNARE associated Golgi protein
HCV85_013165	COG0398	Pfam SNARE associated Golgi protein
HCV85_013170	COG0708	Exodeoxyribonuclease III
HCV85_013180	COG3138	arginine N-succinyltransferase
HCV85_013190	COG3724	N-succinylarginine dihydrolase activity
HCV85_013200	COG3678	ATP-independent chaperone mediated protein folding
HCV85_013205	COG0322	excinuclease ABC activity
HCV85_013215	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCV85_013220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV85_013230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV85_013235	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCV85_013240	COG2169	Transcriptional regulator
HCV85_013240	COG1917	Cupin 2, conserved barrel domain protein
HCV85_013245	COG1486	melibiose metabolic process
HCV85_013255	COG0753	catalase activity
HCV85_013265	COG1823	symporter activity
HCV85_013270	COG1988	membrane-bound metal-dependent
HCV85_013275	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_013280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCV85_013310	COG0727	PFAM Uncharacterised protein family (UPF0153)
HCV85_013315	COG3047	cAMP biosynthetic process
HCV85_013325	COG4774	siderophore transport
HCV85_013380	COG0134	indole-3-glycerol-phosphate synthase activity
HCV85_013380	COG0135	phosphoribosylanthranilate isomerase activity
HCV85_013385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCV85_013385	COG0512	Glutamine amidotransferase of anthranilate synthase
HCV85_013390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCV85_013400	COG0009	L-threonylcarbamoyladenylate synthase
HCV85_013410	COG0583	DNA-binding transcription factor activity
HCV85_013420	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HCV85_013425	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_013435	COG0616	signal peptide processing
HCV85_013460	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HCV85_013470	COG0671	phosphoesterase, PA-phosphatase related
HCV85_013475	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HCV85_013480	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HCV85_013490	COG0023	Translation Initiation Factor
HCV85_013500	COG1349	DNA-binding transcription factor activity
HCV85_013515	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCV85_013515	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCV85_013520	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HCV85_013530	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HCV85_013545	COG4171	peptide transport system, permease
HCV85_013660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HCV85_013710	COG5484	DNA packaging
HCV85_013710	COG3728	DNA packaging
HCV85_013805	COG1196	nuclear chromosome segregation
HCV85_013880	COG3344	reverse transcriptase
HCV85_013885	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HCV85_013890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCV85_013900	COG2135	peptidase activity
HCV85_013915	COG0702	epimerase
HCV85_013930	COG1473	amidohydrolase
HCV85_013940	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HCV85_013945	COG1842	Phage shock protein A
HCV85_013955	COG1983	PspC domain protein
HCV85_013965	COG3106	COG3106 Predicted ATPase
HCV85_013975	COG0583	DNA-binding transcription factor activity
HCV85_013980	COG1486	melibiose metabolic process
HCV85_013990	COG3180	Ammonia monooxygenase
HCV85_013995	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HCV85_014000	COG4948	Mandelate Racemase Muconate Lactonizing
HCV85_014005	COG2866	Carboxypeptidase
HCV85_014015	COG4166	transmembrane transport
HCV85_014045	COG0656	L-ascorbic acid biosynthetic process
HCV85_014065	COG0583	DNA-binding transcription factor activity
HCV85_014070	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_014075	COG1078	dGTPase activity
HCV85_014080	COG0693	protein deglycase activity
HCV85_014085	COG0582	viral genome integration into host DNA
HCV85_014190	COG0484	heat shock protein binding
HCV85_014200	COG3772	lysozyme
HCV85_014220	COG1783	phage Terminase large subunit
HCV85_014225	COG3567	Phage-associated protein, HI1409 family
HCV85_014305	COG0739	heme binding
HCV85_014305	COG0741	lytic transglycosylase activity
HCV85_014305	COG1196	nuclear chromosome segregation
HCV85_014420	COG2885	chlorophyll binding
HCV85_014515	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_014520	COG1309	transcriptional regulator
HCV85_014525	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_014545	COG0583	DNA-binding transcription factor activity
HCV85_014575	COG0604	alcohol dehydrogenase
HCV85_014580	COG0436	Aminotransferase
HCV85_014595	COG2011	ABC-type metal ion transport system permease component
HCV85_014600	COG1448	Aminotransferase
HCV85_014610	COG1522	sequence-specific DNA binding
HCV85_014615	COG1113	amino acid transport
HCV85_014630	COG0673	inositol 2-dehydrogenase activity
HCV85_014635	COG1349	DNA-binding transcription factor activity
HCV85_014645	COG0513	Belongs to the DEAD box helicase family
HCV85_014655	COG0589	response to stress
HCV85_014665	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HCV85_014670	COG1013	pyruvate-flavodoxin oxidoreductase activity
HCV85_014670	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HCV85_014670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCV85_014670	COG0674	pyruvate-flavodoxin oxidoreductase activity
HCV85_014675	COG3042	response to heat
HCV85_014680	COG3187	Heat shock protein
HCV85_014685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCV85_014690	COG0586	Pfam SNARE associated Golgi protein
HCV85_014695	COG2911	Protein conserved in bacteria
HCV85_014705	COG3784	Protein of unknown function (DUF1318)
HCV85_014710	COG2207	Transcriptional regulator
HCV85_014715	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_014735	COG2030	dehydratase
HCV85_014735	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_014740	COG3396	Phenylacetate-CoA oxygenase
HCV85_014745	COG3460	Phenylacetate-CoA oxygenase
HCV85_014750	COG3396	Phenylacetate-CoA oxygenase
HCV85_014755	COG2151	metal-sulfur cluster biosynthetic enzyme
HCV85_014760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCV85_014765	COG1024	Enoyl-CoA hydratase
HCV85_014770	COG1024	Enoyl-CoA hydratase
HCV85_014775	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCV85_014780	COG2050	protein possibly involved in aromatic compounds catabolism
HCV85_014785	COG0183	Belongs to the thiolase family
HCV85_014790	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HCV85_014795	COG3327	negative regulation of DNA-templated transcription, initiation
HCV85_014800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCV85_014815	COG1643	Atp-dependent helicase
HCV85_014820	COG4122	O-methyltransferase activity
HCV85_014845	COG0583	DNA-binding transcription factor activity
HCV85_014850	COG0667	Aldo Keto reductase
HCV85_014855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCV85_014865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCV85_014870	COG3138	arginine N-succinyltransferase
HCV85_014875	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_014880	COG3724	N-succinylarginine dihydrolase activity
HCV85_014885	COG2988	succinylglutamate desuccinylase activity
HCV85_014890	COG1113	amino acid transport
HCV85_014895	COG0477	Major facilitator Superfamily
HCV85_014900	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HCV85_014910	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_014915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCV85_014920	COG0401	homolog of Blt101
HCV85_014925	COG5562	phage envelope protein
HCV85_014930	COG0425	Belongs to the sulfur carrier protein TusA family
HCV85_014935	COG2391	methyltransferase activity
HCV85_014960	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HCV85_014965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV85_014965	COG1263	PTS System
HCV85_014970	COG1609	Transcriptional regulator
HCV85_014975	COG5339	Protein conserved in bacteria
HCV85_014980	COG1482	cell wall glycoprotein biosynthetic process
HCV85_014985	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HCV85_014985	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HCV85_014990	COG0114	fumarate hydratase activity
HCV85_015000	COG2205	protein histidine kinase activity
HCV85_015010	COG0745	RESPONSE REGULATOR receiver
HCV85_015015	COG3136	membrane protein required for alginate biosynthesis
HCV85_015025	COG0531	amino acid
HCV85_015040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HCV85_015045	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HCV85_015060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCV85_015075	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HCV85_015090	COG0583	DNA-binding transcription factor activity
HCV85_015095	COG2840	Smr protein MutS2
HCV85_015100	COG1414	Transcriptional regulator
HCV85_015110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HCV85_015115	COG0183	Belongs to the thiolase family
HCV85_015125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCV85_015130	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCV85_015140	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HCV85_015140	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HCV85_015160	COG4565	transcriptional regulatory protein
HCV85_015165	COG3290	protein histidine kinase activity
HCV85_015190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCV85_015200	COG0679	Auxin Efflux Carrier
HCV85_015230	COG0628	permease
HCV85_015250	COG3591	Belongs to the peptidase S1B family
HCV85_015260	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HCV85_015265	COG2814	Major facilitator Superfamily
HCV85_015270	COG0583	DNA-binding transcription factor activity
HCV85_015275	COG1940	carbohydrate kinase activity
HCV85_015280	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HCV85_015295	COG3302	dmso reductase anchor subunit
HCV85_015300	COG0437	4 iron, 4 sulfur cluster binding
HCV85_015305	COG0243	molybdopterin cofactor binding
HCV85_015320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCV85_015335	COG2271	Major facilitator Superfamily
HCV85_015340	COG0246	Mannitol dehydrogenase
HCV85_015345	COG0589	response to stress
HCV85_015350	COG1802	Transcriptional regulator
HCV85_015355	COG4221	oxidoreductase activity
HCV85_015370	COG2207	Transcriptional regulator
HCV85_015375	COG2135	peptidase activity
HCV85_015390	COG2197	response regulator
HCV85_015405	COG0071	Belongs to the small heat shock protein (HSP20) family
HCV85_015410	COG1546	Belongs to the CinA family
HCV85_015415	COG2200	EAL domain
HCV85_015425	COG3111	PFAM Bacterial OB fold (BOF) protein
HCV85_015435	COG1764	response to oxidative stress
HCV85_015460	COG3781	membrane
HCV85_015465	COG0243	molybdopterin cofactor binding
HCV85_015470	COG0583	DNA-binding transcription factor activity
HCV85_015475	COG2814	Major facilitator Superfamily
HCV85_015480	COG1285	pathogenesis
HCV85_015485	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HCV85_015495	COG0583	DNA-binding transcription factor activity
HCV85_015515	COG0519	Catalyzes the synthesis of GMP from XMP
HCV85_015515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HCV85_015555	COG0596	Alpha beta hydrolase
HCV85_015565	COG2205	protein histidine kinase activity
HCV85_015580	COG0076	glutamate decarboxylase activity
HCV85_015585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCV85_015590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCV85_015595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCV85_015600	COG1116	anion transmembrane transporter activity
HCV85_015605	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HCV85_015620	COG0673	inositol 2-dehydrogenase activity
HCV85_015635	COG3706	GGDEF domain
HCV85_015640	COG0402	S-adenosylhomocysteine deaminase activity
HCV85_015645	COG1953	Uracil, thiamine, allantoin
HCV85_015680	COG0406	alpha-ribazole phosphatase activity
HCV85_015695	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HCV85_015710	COG2207	Transcriptional regulator
HCV85_015725	COG0583	DNA-binding transcription factor activity
HCV85_015740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCV85_015765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCV85_015810	COG0765	amino acid transport
HCV85_015820	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HCV85_015830	COG2070	2-Nitropropane dioxygenase
HCV85_015835	COG0583	DNA-binding transcription factor activity
HCV85_015845	COG1902	pentaerythritol trinitrate reductase activity
HCV85_015850	COG4529	Protein conserved in bacteria
HCV85_015855	COG0477	Major facilitator Superfamily
HCV85_015885	COG2223	nitrite transmembrane transporter activity
HCV85_015895	COG1609	Transcriptional regulator
HCV85_015900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_015910	COG3037	sugar-specific permease SgaT UlaA
HCV85_015915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCV85_015930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV85_015935	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HCV85_015935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV85_015935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCV85_015950	COG0583	DNA-binding transcription factor activity
HCV85_015955	COG0583	DNA-binding transcription factor activity
HCV85_015960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCV85_015970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCV85_015985	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV85_015995	COG1609	Transcriptional regulator
HCV85_016025	COG1652	LysM domain
HCV85_016050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HCV85_016050	COG0456	acetyltransferase
HCV85_016060	COG0667	Aldo Keto reductase
HCV85_016065	COG0667	Aldo Keto reductase
HCV85_016070	COG3386	PFAM SMP-30 Gluconolaconase
HCV85_016075	COG0667	Aldo Keto reductase
HCV85_016100	COG4977	sequence-specific DNA binding
HCV85_016120	COG4977	sequence-specific DNA binding
HCV85_016125	COG1349	DNA-binding transcription factor activity
HCV85_016140	COG1349	DNA-binding transcription factor activity
HCV85_016145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCV85_016150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV85_016155	COG0738	Major facilitator superfamily
HCV85_016200	COG1929	Belongs to the glycerate kinase type-1 family
HCV85_016205	COG3835	regulator
HCV85_016225	COG2186	Transcriptional regulator
HCV85_016230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV85_016230	COG1263	PTS System
HCV85_016240	COG2814	Major facilitator Superfamily
HCV85_016245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_016245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_016260	COG2819	hydrolase of the alpha beta superfamily
HCV85_016265	COG3300	MHYT domain
HCV85_016265	COG5001	Diguanylate cyclase
HCV85_016300	COG3188	usher protein
HCV85_016310	COG1649	PFAM Uncharacterised BCR, COG1649
HCV85_016315	COG3550	peptidyl-serine autophosphorylation
HCV85_016320	COG1396	sequence-specific DNA binding
HCV85_016325	COG2351	hydroxyisourate hydrolase activity
HCV85_016330	COG3195	allantoin biosynthetic process
HCV85_016330	COG3648	Uricase
HCV85_016335	COG2233	PERMEase
HCV85_016365	COG2207	Transcriptional regulator
HCV85_016380	COG4628	conserved protein (DUF2132)
HCV85_016400	COG2011	ABC-type metal ion transport system permease component
HCV85_016405	COG2070	2-Nitropropane dioxygenase
HCV85_016415	COG0477	Major facilitator Superfamily
HCV85_016485	COG2199	diguanylate cyclase activity
HCV85_016500	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_016505	COG0583	DNA-binding transcription factor activity
HCV85_016515	COG0039	L-malate dehydrogenase activity
HCV85_016520	COG1349	DNA-binding transcription factor activity
HCV85_016525	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HCV85_016530	COG3395	kinase activity
HCV85_016540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCV85_016555	COG2731	YhcH YjgK YiaL family protein
HCV85_016560	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_016590	COG4977	sequence-specific DNA binding
HCV85_016600	COG0697	spore germination
HCV85_016605	COG2814	Major facilitator Superfamily
HCV85_016615	COG0410	ABC transporter
HCV85_016620	COG1129	ABC transporter
HCV85_016635	COG0683	leucine binding
HCV85_016640	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCV85_016675	COG2223	nitrite transmembrane transporter activity
HCV85_016680	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCV85_016695	COG1349	DNA-binding transcription factor activity
HCV85_016700	COG2084	Dehydrogenase
HCV85_016705	COG3395	kinase activity
HCV85_016710	COG0235	Class ii aldolase
HCV85_016715	COG3622	Belongs to the hyi family
HCV85_016720	COG2610	gluconate transmembrane transporter activity
HCV85_016725	COG2207	Transcriptional regulator
HCV85_016725	COG3708	Transcriptional regulator
HCV85_016740	COG2323	membrane
HCV85_016750	COG0366	Alpha amylase catalytic
HCV85_016760	COG3685	Protein conserved in bacteria
HCV85_016770	COG3729	General stress protein
HCV85_016775	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_016815	COG0488	(ABC) transporter
HCV85_016830	COG1064	alcohol dehydrogenase
HCV85_016835	COG0747	negative chemotaxis
HCV85_016845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCV85_016855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCV85_016865	COG2814	Major facilitator Superfamily
HCV85_016875	COG2326	polyphosphate kinase activity
HCV85_016890	COG2864	formate dehydrogenase
HCV85_016895	COG0437	4 iron, 4 sulfur cluster binding
HCV85_016920	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HCV85_016930	COG3485	protocatechuate 3,4-dioxygenase
HCV85_016935	COG4829	muconolactone delta-isomerase
HCV85_016940	COG4948	Mandelate Racemase Muconate Lactonizing
HCV85_016945	COG1414	Transcriptional regulator
HCV85_016965	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HCV85_016970	COG1140	nitrate reductase beta subunit
HCV85_016975	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HCV85_016980	COG2181	nitrate reductase activity
HCV85_016985	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HCV85_016990	COG1178	ABC-type Fe3 transport system permease component
HCV85_016995	COG1840	ABC-type Fe3 transport system, periplasmic component
HCV85_017000	COG3842	ATPase activity
HCV85_017005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCV85_017020	COG2211	Major facilitator Superfamily
HCV85_017035	COG0625	glutathione transferase activity
HCV85_017045	COG1126	abc transporter atp-binding protein
HCV85_017050	COG0765	amino acid transport
HCV85_017060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV85_017065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCV85_017070	COG1473	amidohydrolase
HCV85_017075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCV85_017080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCV85_017105	COG4772	TonB-dependent receptor
HCV85_017110	COG1228	amidohydrolase
HCV85_017115	COG3691	Protein conserved in bacteria
HCV85_017130	COG2130	NADP-dependent
HCV85_017140	COG1247	-acetyltransferase
HCV85_017145	COG3238	Protein conserved in bacteria
HCV85_017155	COG0747	negative chemotaxis
HCV85_017160	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_017195	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_017200	COG1177	transmembrane transport
HCV85_017205	COG1176	ABC-type spermidine putrescine transport system, permease component I
HCV85_017210	COG3842	ATPase activity
HCV85_017215	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HCV85_017220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCV85_017225	COG1271	oxidase subunit
HCV85_017230	COG1294	oxidase, subunit
HCV85_017250	COG0826	peptidase U32
HCV85_017260	COG1396	sequence-specific DNA binding
HCV85_017265	COG3135	benzoate transporter
HCV85_017270	COG2207	Transcriptional regulator
HCV85_017270	COG3708	Transcriptional regulator
HCV85_017285	COG0500	methyltransferase
HCV85_017290	COG1275	C4-dicarboxylate transporter malic acid transport protein
HCV85_017295	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCV85_017300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCV85_017315	COG2272	Belongs to the type-B carboxylesterase lipase family
HCV85_017320	COG5383	Protein conserved in bacteria
HCV85_017325	COG3485	protocatechuate 3,4-dioxygenase
HCV85_017330	COG3485	protocatechuate 3,4-dioxygenase
HCV85_017335	COG0583	DNA-binding transcription factor activity
HCV85_017355	COG3038	cytochrome b561
HCV85_017375	COG2814	Major facilitator Superfamily
HCV85_017385	COG0673	inositol 2-dehydrogenase activity
HCV85_017395	COG2723	6-phospho-beta-galactosidase activity
HCV85_017430	COG4659	FMN binding
HCV85_017440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HCV85_017450	COG0625	glutathione transferase activity
HCV85_017455	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HCV85_017470	COG3895	Periplasmic Protein
HCV85_017485	COG3706	GGDEF domain
HCV85_017500	COG1566	PFAM secretion protein HlyD family protein
HCV85_017505	COG1289	transmembrane transporter activity
HCV85_017510	COG2032	superoxide dismutase activity
HCV85_017515	COG4989	oxidoreductase activity
HCV85_017520	COG3313	Fe-S protein
HCV85_017525	COG1309	transcriptional regulator
HCV85_017530	COG1902	pentaerythritol trinitrate reductase activity
HCV85_017535	COG0346	lactoylglutathione lyase activity
HCV85_017545	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HCV85_017550	COG0791	NLP P60 protein
HCV85_017565	COG2814	Major facilitator Superfamily
HCV85_017580	COG0583	DNA-binding transcription factor activity
HCV85_017585	COG2814	Major facilitator Superfamily
HCV85_017590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HCV85_017595	COG0307	riboflavin synthase, alpha
HCV85_017650	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HCV85_017685	COG1349	DNA-binding transcription factor activity
HCV85_017690	COG0346	lactoylglutathione lyase activity
HCV85_017715	COG0444	Belongs to the ABC transporter superfamily
HCV85_017720	COG4608	Belongs to the ABC transporter superfamily
HCV85_017775	COG0402	S-adenosylhomocysteine deaminase activity
HCV85_017800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCV85_017805	COG0277	FAD linked oxidase domain protein
HCV85_017830	COG0583	DNA-binding transcription factor activity
HCV85_017840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HCV85_017850	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCV85_017855	COG2610	gluconate transmembrane transporter activity
HCV85_017860	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_017890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCV85_017905	COG0745	RESPONSE REGULATOR receiver
HCV85_017910	COG5002	protein histidine kinase activity
HCV85_017910	COG3850	Histidine kinase
HCV85_017925	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HCV85_017945	COG3088	subunit of a heme lyase
HCV85_017945	COG4235	cytochrome complex assembly
HCV85_017950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCV85_017955	COG1138	Cytochrome C-type biogenesis protein
HCV85_017970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCV85_017975	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCV85_017980	COG4133	protoheme IX ABC transporter activity
HCV85_018010	COG1175	transmembrane transport
HCV85_018020	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HCV85_018025	COG3383	formate dehydrogenase (NAD+) activity
HCV85_018065	COG1126	abc transporter atp-binding protein
HCV85_018070	COG0765	amino acid transport
HCV85_018090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV85_018095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV85_018100	COG1120	ATPase activity
HCV85_018105	COG4774	siderophore transport
HCV85_018110	COG1116	anion transmembrane transporter activity
HCV85_018115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCV85_018135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCV85_018140	COG0583	DNA-binding transcription factor activity
HCV85_018160	COG2814	Major facilitator Superfamily
HCV85_018195	COG1414	Transcriptional regulator
HCV85_018200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCV85_018205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV85_018210	COG1120	ATPase activity
HCV85_018220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCV85_018225	COG2271	Major facilitator Superfamily
HCV85_018230	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HCV85_018230	COG1082	Xylose isomerase domain protein TIM barrel
HCV85_018235	COG1309	transcriptional regulator
HCV85_018265	COG1376	ErfK ybiS ycfS ynhG family protein
HCV85_018280	COG0719	Fe-S assembly protein
HCV85_018285	COG0396	ATPase activity
HCV85_018290	COG0719	Fe-S assembly protein
HCV85_018295	COG0316	Belongs to the HesB IscA family
HCV85_018315	COG1309	transcriptional regulator
HCV85_018320	COG1304	FMN binding
HCV85_018345	COG0583	DNA-binding transcription factor activity
HCV85_018355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV85_018360	COG1120	ATPase activity
HCV85_018385	COG2261	transglycosylase associated protein
HCV85_018390	COG2050	protein possibly involved in aromatic compounds catabolism
HCV85_018395	COG0277	FAD linked oxidase domain protein
HCV85_018395	COG0247	lactate metabolic process
HCV85_018400	COG0628	permease
HCV85_018410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCV85_018410	COG0574	Belongs to the PEP-utilizing enzyme family
HCV85_018425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HCV85_018430	COG4256	Hemin uptake protein
HCV85_018440	COG0791	NLP P60 protein
HCV85_018450	COG0386	Belongs to the glutathione peroxidase family
HCV85_018470	COG0583	DNA-binding transcription factor activity
HCV85_018490	COG0072	phenylalanine-tRNA ligase activity
HCV85_018490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCV85_018530	COG3137	Salt-induced outer membrane protein
HCV85_018535	COG1105	Belongs to the carbohydrate kinase PfkB family
HCV85_018545	COG3001	Fructosamine kinase
HCV85_018555	COG2350	Protein conserved in bacteria
HCV85_018565	COG2353	YceI-like domain
HCV85_018585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCV85_018595	COG0444	Belongs to the ABC transporter superfamily
HCV85_018600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCV85_018605	COG0601	transmembrane transport
HCV85_018610	COG4166	transmembrane transport
HCV85_018615	COG2095	MarC family integral membrane protein
HCV85_018625	COG1454	alcohol dehydrogenase
HCV85_018625	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_018630	COG1435	thymidine kinase activity
HCV85_018640	COG2916	Histone family protein nucleoid-structuring protein H-NS
HCV85_018645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCV85_018650	COG0745	RESPONSE REGULATOR receiver
HCV85_018655	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCV85_018665	COG0788	formyltetrahydrofolate deformylase activity
HCV85_018700	COG1522	sequence-specific DNA binding
HCV85_018710	COG2181	nitrate reductase activity
HCV85_018715	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HCV85_018720	COG1140	nitrate reductase beta subunit
HCV85_018725	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HCV85_018735	COG2223	nitrite transmembrane transporter activity
HCV85_018740	COG3850	Histidine kinase
HCV85_018745	COG2197	response regulator
HCV85_018750	COG4932	domain protein
HCV85_018755	COG0243	molybdopterin cofactor binding
HCV85_018760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCV85_018760	COG2146	nitrite reductase [NAD(P)H] activity
HCV85_018765	COG1116	anion transmembrane transporter activity
HCV85_018775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCV85_018780	COG3707	response regulator
HCV85_018785	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HCV85_018795	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HCV85_018800	COG4572	Cation transport regulator
HCV85_018805	COG0387	Pfam Sodium calcium exchanger
HCV85_018825	COG2890	protein-(glutamine-N5) methyltransferase activity
HCV85_018855	COG0659	secondary active sulfate transmembrane transporter activity
HCV85_018875	COG0012	GTP binding
HCV85_018970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCV85_019050	COG2885	chlorophyll binding
HCV85_019070	COG3122	Protein conserved in bacteria
HCV85_019085	COG0583	DNA-binding transcription factor activity
HCV85_019115	COG0583	DNA-binding transcription factor activity
HCV85_019150	COG1882	Formate acetyltransferase
HCV85_019165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCV85_019170	COG0583	DNA-binding transcription factor activity
HCV85_019210	COG2308	Evidence 4 Homologs of previously reported genes of
HCV85_019220	COG4774	siderophore transport
HCV85_019230	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCV85_019255	COG2719	SpoVR family
HCV85_019285	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCV85_019300	COG2894	cell division
HCV85_019310	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HCV85_019320	COG3065	identical protein binding
HCV85_019330	COG1199	ATP-dependent helicase activity
HCV85_019335	COG0251	oxidation-reduction process
HCV85_019355	COG1760	l-serine dehydratase
HCV85_019360	COG2200	EAL domain
HCV85_019365	COG1253	flavin adenine dinucleotide binding
HCV85_019370	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV85_019370	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_019375	COG3715	PTS system
HCV85_019380	COG3716	PTS system mannose fructose sorbose family IID component
HCV85_019395	COG2226	methyltransferase
HCV85_019400	COG0768	penicillin binding
HCV85_019430	COG1414	Transcriptional regulator
HCV85_019435	COG2814	Major facilitator Superfamily
HCV85_019455	COG1956	GAF domain-containing protein
HCV85_019460	COG2995	paraquat-inducible protein a
HCV85_019465	COG3008	intermembrane lipid transfer
HCV85_019490	COG2990	Protein conserved in bacteria
HCV85_019505	COG1276	copper resistance
HCV85_019510	COG2372	response to copper ion
HCV85_019520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HCV85_019525	COG1770	oligopeptidase
HCV85_019530	COG2979	Protein of unknown function (DUF533)
HCV85_019535	COG3141	response to X-ray
HCV85_019545	COG0800	Aldolase
HCV85_019550	COG0129	dihydroxy-acid dehydratase activity
HCV85_019555	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HCV85_019565	COG1737	Transcriptional regulator
HCV85_019575	COG1560	Kdo2-lipid A biosynthetic process
HCV85_019580	COG0739	heme binding
HCV85_019585	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HCV85_019595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCV85_019620	COG0494	nUDIX hydrolase
HCV85_019630	COG1335	isochorismatase
HCV85_019635	COG1801	Protein of unknown function DUF72
HCV85_019640	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HCV85_019660	COG3102	Protein conserved in bacteria
HCV85_019670	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HCV85_019695	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV85_019705	COG1879	ABC-type sugar transport system periplasmic component
HCV85_019715	COG1528	Iron-storage protein
HCV85_019725	COG2211	Major facilitator Superfamily
HCV85_019735	COG0477	Major facilitator Superfamily
HCV85_019750	COG1528	Iron-storage protein
HCV85_019760	COG0814	amino acid
HCV85_019765	COG3318	Belongs to the UPF0149 family
HCV85_019765	COG3012	SEC-C Motif Domain Protein
HCV85_019800	COG2197	response regulator
HCV85_019810	COG2197	response regulator
HCV85_019815	COG1126	abc transporter atp-binding protein
HCV85_019820	COG0765	amino acid transport
HCV85_019830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV85_019835	COG0366	Alpha amylase catalytic
HCV85_019865	COG2354	Protein conserved in bacteria
HCV85_019870	COG0697	spore germination
HCV85_019875	COG3727	T/G mismatch-specific endonuclease activity
HCV85_019880	COG0270	DNA (cytosine-5-)-methyltransferase activity
HCV85_019885	COG1418	mRNA catabolic process
HCV85_019895	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HCV85_019915	COG0251	oxidation-reduction process
HCV85_019950	COG0025	NhaP-type Na H and K H
HCV85_019955	COG1309	transcriptional regulator
HCV85_019960	COG0604	alcohol dehydrogenase
HCV85_019980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HCV85_019990	COG0534	Mate efflux family protein
HCV85_020000	COG0582	viral genome integration into host DNA
HCV85_020105	COG2916	Histone family protein nucleoid-structuring protein H-NS
HCV85_020145	COG3706	GGDEF domain
HCV85_020170	COG3615	Tellurite resistance protein tehB
HCV85_020180	COG5001	Diguanylate cyclase
HCV85_020180	COG3300	MHYT domain
HCV85_020190	COG0477	Major facilitator Superfamily
HCV85_020195	COG0095	Lipoate-protein ligase
HCV85_020200	COG0583	DNA-binding transcription factor activity
HCV85_020205	COG1942	4-Oxalocrotonate Tautomerase
HCV85_020215	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HCV85_020235	COG1289	transmembrane transporter activity
HCV85_020245	COG3344	reverse transcriptase
HCV85_020425	COG3772	lysozyme
HCV85_020495	COG0305	Participates in initiation and elongation during chromosome replication
HCV85_020595	COG2501	S4 domain
HCV85_020605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCV85_020620	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCV85_020625	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HCV85_020645	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HCV85_020650	COG4181	ATPase activity
HCV85_020655	COG2755	lipolytic protein G-D-S-L family
HCV85_020660	COG0300	oxidoreductase activity
HCV85_020665	COG3118	belongs to the thioredoxin family
HCV85_020670	COG0390	transport system, permease component
HCV85_020675	COG4619	ABC transporter
HCV85_020680	COG0330	HflC and HflK could
HCV85_020685	COG1585	Membrane protein implicated in regulation of membrane protease activity
HCV85_020700	COG3735	TraB family
HCV85_020705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HCV85_020715	COG2223	nitrite transmembrane transporter activity
HCV85_020720	COG4651	solute:proton antiporter activity
HCV85_020720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCV85_020725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV85_020765	COG2832	Protein of unknown function (DUF454)
HCV85_020770	COG3923	Primosomal replication protein n
HCV85_020780	COG5464	transposase or invertase
HCV85_020785	COG3264	Mechanosensitive ion channel
HCV85_020785	COG1196	nuclear chromosome segregation
HCV85_020790	COG1309	transcriptional regulator
HCV85_020795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV85_020800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCV85_020815	COG0110	maltose O-acetyltransferase activity
HCV85_020865	COG1874	Beta-galactosidase
HCV85_020870	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HCV85_020875	COG3833	ABC-type maltose transport systems, permease component
HCV85_020880	COG1175	transmembrane transport
HCV85_020885	COG2182	Extracellular solute-binding protein
HCV85_020895	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HCV85_020910	COG2364	Membrane
HCV85_020940	COG3695	enzyme binding
HCV85_020945	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HCV85_020950	COG1946	Acyl-CoA thioesterase
HCV85_020955	COG0004	ammonium transporteR
HCV85_020960	COG0347	Belongs to the P(II) protein family
HCV85_020965	COG1132	(ABC) transporter
HCV85_020970	COG1132	(ABC) transporter
HCV85_020975	COG1522	sequence-specific DNA binding
HCV85_020990	COG4533	DNA binding
HCV85_021000	COG0824	Thioesterase
HCV85_021005	COG1555	photosystem II stabilization
HCV85_021010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCV85_021015	COG0776	regulation of translation
HCV85_021020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HCV85_021040	COG0271	Belongs to the BolA IbaG family
HCV85_021045	COG3056	Lipoprotein
HCV85_021050	COG2223	nitrite transmembrane transporter activity
HCV85_021055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCV85_021060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCV85_021065	COG1845	cytochrome c oxidase, subunit III
HCV85_021070	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HCV85_021085	COG1414	Transcriptional regulator
HCV85_021090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCV85_021095	COG1053	succinate dehydrogenase
HCV85_021105	COG1053	succinate dehydrogenase
HCV85_021120	COG0673	inositol 2-dehydrogenase activity
HCV85_021125	COG2814	Major facilitator Superfamily
HCV85_021135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCV85_021140	COG0693	protein deglycase activity
HCV85_021160	COG0142	geranyltranstransferase activity
HCV85_021170	COG0667	Aldo Keto reductase
HCV85_021175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HCV85_021195	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCV85_021195	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCV85_021205	COG4238	major outer membrane lipoprotein
HCV85_021225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCV85_021230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCV85_021235	COG1862	Preprotein translocase
HCV85_021260	COG0450	alkyl hydroperoxide reductase
HCV85_021270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_021285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV85_021295	COG1228	amidohydrolase
HCV85_021305	COG1335	isochorismatase
HCV85_021310	COG0583	DNA-binding transcription factor activity
HCV85_021315	COG0366	Alpha amylase catalytic
HCV85_021340	COG0420	3'-5' exonuclease activity
HCV85_021345	COG0419	ATPase involved in DNA repair
HCV85_021350	COG1940	carbohydrate kinase activity
HCV85_021365	COG4126	flavin adenine dinucleotide binding
HCV85_021375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCV85_021380	COG3416	Protein conserved in bacteria
HCV85_021390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCV85_021400	COG1785	Belongs to the alkaline phosphatase family
HCV85_021440	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HCV85_021445	COG1335	isochorismatase
HCV85_021450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCV85_021455	COG0113	porphobilinogen synthase activity
HCV85_021465	COG2175	clavaminate synthase activity
HCV85_021470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCV85_021475	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HCV85_021480	COG4521	taurine ABC transporter
HCV85_021485	COG2040	homocysteine
HCV85_021490	COG0833	amino acid
HCV85_021505	COG4303	Ethanolamine ammonia lyase large subunit
HCV85_021510	COG4302	ethanolamine ammonia-lyase activity
HCV85_021550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV85_021555	COG1126	abc transporter atp-binding protein
HCV85_021560	COG0765	amino acid transport
HCV85_021565	COG0765	amino acid transport
HCV85_021580	COG3188	usher protein
HCV85_021605	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HCV85_021615	COG3639	organic phosphonate transmembrane transporter activity
HCV85_021635	COG0791	NLP P60 protein
HCV85_021660	COG0582	viral genome integration into host DNA
HCV85_021665	COG1192	Involved in chromosome partitioning
HCV85_021725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCV85_021730	COG0022	dehydrogenase e1 component
HCV85_021735	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCV85_021740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCV85_021760	COG1070	Carbohydrate kinase
HCV85_021765	COG1028	Short-chain dehydrogenase reductase Sdr
HCV85_021770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCV85_021775	COG3775	system Galactitol-specific IIC component
HCV85_021780	COG0625	glutathione transferase activity
HCV85_021785	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HCV85_021800	COG0579	oxidoreductase
HCV85_021805	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_021810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCV85_021815	COG1113	amino acid transport
HCV85_021820	COG1802	Transcriptional regulator
HCV85_021840	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCV85_021845	COG0454	-acetyltransferase
HCV85_021860	COG2991	Protein conserved in bacteria
HCV85_021875	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HCV85_021880	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HCV85_021895	COG3034	peptidoglycan biosynthetic process
HCV85_021900	COG0121	glutamine amidotransferase
HCV85_021910	COG1960	acyl-CoA dehydrogenase activity
HCV85_021915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCV85_021925	COG0583	DNA-binding transcription factor activity
HCV85_021935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HCV85_021945	COG2226	methyltransferase
HCV85_021955	COG1388	LysM domain
HCV85_021955	COG0741	lytic transglycosylase activity
HCV85_021960	COG2226	methyltransferase
HCV85_021970	COG2814	Major facilitator Superfamily
HCV85_021975	COG0583	DNA-binding transcription factor activity
HCV85_021980	COG0656	L-ascorbic acid biosynthetic process
HCV85_022015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HCV85_022025	COG2011	ABC-type metal ion transport system permease component
HCV85_022030	COG1464	Belongs to the NlpA lipoprotein family
HCV85_022040	COG1720	tRNA m6t6A37 methyltransferase activity
HCV85_022050	COG0791	NLP P60 protein
HCV85_022055	COG3015	lipoprotein NlpE involved in copper resistance
HCV85_022060	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HCV85_022075	COG4568	rho-dependent transcription termination
HCV85_022085	COG0346	lactoylglutathione lyase activity
HCV85_022090	COG1982	Orn Lys Arg decarboxylase major
HCV85_022130	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HCV85_022140	COG0750	zinc metalloprotease
HCV85_022145	COG0575	Belongs to the CDS family
HCV85_022155	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HCV85_022180	COG0024	Methionine aminopeptidase
HCV85_022185	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HCV85_022200	COG3835	regulator
HCV85_022205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCV85_022225	COG2860	membrane
HCV85_022245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCV85_022250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCV85_022255	COG1120	ATPase activity
HCV85_022260	COG4774	siderophore transport
HCV85_022265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCV85_022360	COG1643	Atp-dependent helicase
HCV85_022365	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HCV85_022385	COG0617	tRNA 3'-terminal CCA addition
HCV85_022390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HCV85_022410	COG0726	polysaccharide deacetylase
HCV85_022415	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_022420	COG0842	Transport permease protein
HCV85_022425	COG1131	(ABC) transporter
HCV85_022430	COG0288	reversible hydration of carbon dioxide
HCV85_022445	COG4993	Dehydrogenase
HCV85_022450	COG2132	Multicopper oxidase
HCV85_022500	COG3064	Membrane
HCV85_022515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCV85_022520	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCV85_022525	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HCV85_022530	COG2186	Transcriptional regulator
HCV85_022535	COG1113	amino acid transport
HCV85_022540	COG2211	Major facilitator Superfamily
HCV85_022545	COG3940	Belongs to the glycosyl hydrolase 43 family
HCV85_022550	COG3725	Membrane protein required for beta-lactamase induction
HCV85_022555	COG3023	N-Acetylmuramoyl-L-alanine amidase
HCV85_022565	COG4969	Belongs to the N-Me-Phe pilin family
HCV85_022570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HCV85_022575	COG1459	type II secretion system
HCV85_022600	COG0494	nUDIX hydrolase
HCV85_022620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCV85_022625	COG0849	cell division
HCV85_022650	COG0772	Belongs to the SEDS family
HCV85_022665	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCV85_022670	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCV85_022675	COG0768	penicillin binding
HCV85_022695	COG1609	Transcriptional regulator
HCV85_022705	COG0028	Belongs to the TPP enzyme family
HCV85_022750	COG0738	Major facilitator superfamily
HCV85_022760	COG0583	DNA-binding transcription factor activity
HCV85_022765	COG2271	Major facilitator Superfamily
HCV85_022770	COG2814	Major facilitator Superfamily
HCV85_022790	COG1178	ABC-type Fe3 transport system permease component
HCV85_022800	COG0586	Pfam SNARE associated Golgi protein
HCV85_022820	COG0235	Class ii aldolase
HCV85_022825	COG0417	DNA replication proofreading
HCV85_022835	COG0564	pseudouridine synthase activity
HCV85_022845	COG3493	citrate carrier protein
HCV85_022860	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HCV85_022865	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HCV85_022875	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HCV85_022920	COG0505	Belongs to the CarA family
HCV85_022985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCV85_023010	COG1047	Peptidyl-prolyl cis-trans
HCV85_023025	COG0196	riboflavin kinase activity
HCV85_023035	COG0583	DNA-binding transcription factor activity
HCV85_023060	COG4735	regulation of single-species biofilm formation
HCV85_023065	COG1584	GPR1 FUN34 yaaH family protein
HCV85_023070	COG0477	Major facilitator Superfamily
HCV85_023075	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCV85_023080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCV85_023085	COG1115	amino acid carrier protein
HCV85_023100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HCV85_023110	COG0460	homoserine dehydrogenase
HCV85_023110	COG0527	aspartate kinase activity
HCV85_023120	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HCV85_023130	COG0745	RESPONSE REGULATOR receiver
HCV85_023135	COG4452	Inner membrane protein CreD
HCV85_023140	COG2205	protein histidine kinase activity
HCV85_023145	COG0745	RESPONSE REGULATOR receiver
HCV85_023150	COG3045	CreA protein
HCV85_023155	COG2207	Transcriptional regulator
HCV85_023155	COG3708	Transcriptional regulator
HCV85_023175	COG0741	lytic transglycosylase activity
HCV85_023180	COG0488	(ABC) transporter
HCV85_023190	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HCV85_023195	COG0560	Phosphoserine phosphatase
HCV85_023200	COG3726	membrane protein affecting hemolysin expression
HCV85_023230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCV85_023235	COG0084	hydrolase, TatD family'
HCV85_023240	COG4667	esterase of the alpha-beta hydrolase superfamily
HCV85_023250	COG2823	Periplasmic or secreted lipoprotein
HCV85_023260	COG1011	Hydrolase
HCV85_023265	COG0456	acetyltransferase
HCV85_023270	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HCV85_023305	COG3706	GGDEF domain
HCV85_023310	COG4114	ferric iron reductase
HCV85_023315	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV85_023315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV85_023320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HCV85_023325	COG2197	response regulator
HCV85_023330	COG2197	response regulator
HCV85_023345	COG2966	Psort location CytoplasmicMembrane, score
HCV85_023360	COG1484	DNA-dependent DNA replication
HCV85_023375	COG5464	transposase or invertase
HCV85_023385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCV85_023390	COG3716	PTS system mannose fructose sorbose family IID component
HCV85_023395	COG3715	PTS system
HCV85_023410	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HCV85_023410	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HCV85_023420	COG1063	alcohol dehydrogenase
HCV85_023425	COG1802	Transcriptional regulator
HCV85_023430	COG2271	Major facilitator Superfamily
HCV85_023435	COG0456	acetyltransferase
HCV85_023435	COG1214	PFAM Peptidase M22, glycoprotease
HCV85_023445	COG1737	Transcriptional regulator
HCV85_023450	COG0800	Aldolase
HCV85_023455	COG3734	2-keto-3-deoxy-galactonokinase
HCV85_023470	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HCV85_023500	COG1846	Transcriptional regulator
HCV85_023510	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCV85_023520	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_023525	COG3384	dioxygenase
HCV85_023535	COG3971	2-oxopent-4-enoate hydratase activity
HCV85_023555	COG2368	4-hydroxyphenylacetate
HCV85_023560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCV85_023575	COG1966	Carbon starvation protein
HCV85_023580	COG2879	small protein
HCV85_023585	COG0523	cobalamin synthesis protein
HCV85_023595	COG1012	belongs to the aldehyde dehydrogenase family
HCV85_023600	COG5464	transposase or invertase
HCV85_023605	COG1917	Cupin 2, conserved barrel domain protein
HCV85_023605	COG2207	Transcriptional regulator
HCV85_023615	COG2733	membrane
HCV85_023630	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HCV85_023635	COG1924	4 iron, 4 sulfur cluster binding
HCV85_023650	COG1566	PFAM secretion protein HlyD family protein
HCV85_023660	COG5457	Domain of unknown function (DUF1127)
HCV85_023665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCV85_023675	COG0583	DNA-binding transcription factor activity
HCV85_023680	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCV85_023690	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV85_023695	COG1129	ABC transporter
HCV85_023700	COG1879	ABC-type sugar transport system periplasmic component
HCV85_023710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV85_023715	COG1129	ABC transporter
HCV85_023715	COG0842	Transport permease protein
HCV85_023720	COG0842	Transport permease protein
HCV85_023750	COG2850	peptidyl-arginine hydroxylation
HCV85_023765	COG5002	protein histidine kinase activity
HCV85_023770	COG0745	RESPONSE REGULATOR receiver
HCV85_023775	COG1538	Outer membrane efflux protein
HCV85_023780	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV85_023785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV85_023790	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCV85_023800	COG3040	lipid binding
HCV85_023805	COG0789	Transcriptional regulator
HCV85_023815	COG0300	oxidoreductase activity
HCV85_023830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HCV85_023850	COG3272	Protein of unknown function (DUF1722)
HCV85_023855	COG4580	involved in the transport of maltose and maltodextrins
HCV85_023865	COG2211	Major facilitator Superfamily
HCV85_023870	COG3507	Belongs to the glycosyl hydrolase 43 family
HCV85_023970	COG0582	viral genome integration into host DNA
HCV85_023980	COG0288	reversible hydration of carbon dioxide
HCV85_023985	COG0659	secondary active sulfate transmembrane transporter activity
HCV85_023990	COG1064	alcohol dehydrogenase
HCV85_023995	COG1175	transmembrane transport
HCV85_024000	COG0395	ABC-type sugar transport system, permease component
HCV85_024005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HCV85_024010	COG3842	ATPase activity
HCV85_024015	COG1653	transport
HCV85_024025	COG1082	Xylose isomerase domain protein TIM barrel
HCV85_024035	COG3962	Belongs to the TPP enzyme family
HCV85_024040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV85_024045	COG0837	glucose binding
HCV85_024045	COG1737	Transcriptional regulator
HCV85_024050	COG3718	enzyme involved in inositol metabolism
HCV85_024065	COG0433	COG0433 Predicted ATPase
HCV85_024070	COG0795	lipopolysaccharide-transporting ATPase activity
HCV85_024075	COG0795	lipopolysaccharide-transporting ATPase activity
HCV85_024085	COG2927	DNA polymerase III (CHI subunit)
HCV85_024090	COG0525	valine-tRNA ligase activity
HCV85_024115	COG2188	Transcriptional regulator
HCV85_024120	COG1288	antiporter activity
HCV85_024125	COG1228	amidohydrolase
HCV85_024130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV85_024135	COG2222	sugar isomerase
HCV85_024140	COG2731	YhcH YjgK YiaL family protein
HCV85_024175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCV85_024175	COG1263	PTS System
HCV85_024180	COG0366	Alpha amylase catalytic
HCV85_024185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCV85_024190	COG1486	melibiose metabolic process
HCV85_024215	COG0602	queuosine metabolic process
HCV85_024220	COG2026	Addiction module toxin, RelE StbE family
HCV85_024225	COG3077	Addiction module antitoxin, RelB DinJ family
HCV85_024230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCV85_024230	COG3711	transcriptional antiterminator
HCV85_024235	COG2706	6-phosphogluconolactonase activity
HCV85_024250	COG3964	amidohydrolase
HCV85_024290	COG0312	modulator of DNA gyrase
HCV85_024315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HCV85_024325	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV85_024330	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV85_024335	COG1129	ABC transporter
HCV85_024340	COG1879	ABC-type sugar transport system periplasmic component
HCV85_024360	COG2105	PFAM AIG2 family protein
HCV85_024365	COG2911	Protein conserved in bacteria
HCV85_024370	COG0729	surface antigen
HCV85_024380	COG1253	flavin adenine dinucleotide binding
HCV85_024395	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HCV85_024410	COG1733	regulation of RNA biosynthetic process
HCV85_024415	COG0702	epimerase
HCV85_024425	COG0697	spore germination
HCV85_024435	COG1113	amino acid transport
HCV85_024440	COG0545	Peptidyl-prolyl cis-trans isomerase
HCV85_024445	COG3061	Opacity-associated protein A
HCV85_024455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HCV85_024460	COG2965	DNA replication, synthesis of RNA primer
HCV85_024520	COG1073	alpha beta
HCV85_024525	COG3650	response to hydrogen peroxide
HCV85_024535	COG1960	acyl-CoA dehydrogenase activity
HCV85_024540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCV85_024545	COG0557	exoribonuclease II activity
HCV85_024560	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HCV85_024570	COG0330	HflC and HflK could
HCV85_024575	COG0330	HflC and HflK could
HCV85_024580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCV85_024600	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCV85_024605	COG0802	atpase or kinase
HCV85_024610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HCV85_024610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HCV85_024615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HCV85_024635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCV85_024655	COG3264	Mechanosensitive ion channel
HCV85_024655	COG1511	domain protein
HCV85_024670	COG1053	succinate dehydrogenase
HCV85_024675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCV85_024695	COG2076	Multidrug Resistance protein
HCV85_024700	COG5510	response to toxic substance
HCV85_024715	COG1509	lysine 2,3-aminomutase activity
HCV85_024780	COG0531	amino acid
HCV85_024785	COG3030	protein affecting phage T7 exclusion by the F plasmid
HCV85_024790	COG1027	Aspartate ammonia-lyase
HCV85_024795	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HCV85_024810	COG1309	transcriptional regulator
HCV85_024845	COG0457	Tetratricopeptide repeat
HCV85_024850	COG0726	polysaccharide deacetylase
HCV85_024850	COG1649	PFAM Uncharacterised BCR, COG1649
HCV85_024855	COG1215	transferase activity, transferring glycosyl groups
HCV85_024870	COG0861	Integral membrane protein TerC family
HCV85_024915	COG1486	melibiose metabolic process
HCV85_024920	COG2169	Transcriptional regulator
HCV85_024930	COG2824	Alkylphosphonate utilization operon protein PhnA
HCV85_024935	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HCV85_024940	COG2188	Transcriptional regulator
HCV85_024945	COG3624	Phosphonate C-P lyase system protein PhnG
HCV85_024950	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HCV85_024955	COG3626	phosphonate metabolism
HCV85_024960	COG3627	carbon phosphorus lyase activity
HCV85_024965	COG4107	phosphonate C-P lyase system protein PhnK
HCV85_024970	COG4778	phosphonate C-P lyase system protein PhnL
HCV85_024975	COG3454	Phosphonate metabolism
HCV85_024985	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HCV85_024995	COG0784	Response regulator, receiver
HCV85_024995	COG4191	Histidine kinase
HCV85_025000	COG1129	ABC transporter
HCV85_025005	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV85_025040	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HCV85_025045	COG1301	dicarboxylic acid transport
HCV85_025055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCV85_025060	COG3162	membrane
HCV85_025090	COG3539	Fimbrial protein
HCV85_025095	COG1346	cytolysis
HCV85_025100	COG1380	Effector of murein hydrolase LrgA
HCV85_025105	COG0583	DNA-binding transcription factor activity
HCV85_025110	COG0025	NhaP-type Na H and K H
HCV85_025115	COG2252	PERMEase
HCV85_025120	COG0625	glutathione transferase activity
HCV85_025125	COG0789	Transcriptional regulator
HCV85_025135	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HCV85_025165	COG1234	tRNA 3'-trailer cleavage
HCV85_025170	COG1609	Transcriptional regulator
HCV85_025175	COG0483	inositol monophosphate 1-phosphatase activity
HCV85_025185	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCV85_025205	COG4771	TonB-dependent receptor
HCV85_025210	COG0741	lytic transglycosylase activity
HCV85_025225	COG2315	Protein conserved in bacteria
HCV85_025230	COG0432	Pfam Uncharacterised protein family UPF0047
HCV85_025245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCV85_025250	COG0305	Participates in initiation and elongation during chromosome replication
HCV85_025265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCV85_025275	COG0735	belongs to the Fur family
HCV85_025280	COG3237	CsbD-like
HCV85_025290	COG0534	Mate efflux family protein
HCV85_025300	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HCV85_025370	COG0251	oxidation-reduction process
HCV85_025380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HCV85_025390	COG0527	aspartate kinase activity
HCV85_025445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCV85_025475	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HCV85_025485	COG0456	acetyltransferase
HCV85_025515	COG0151	Belongs to the GarS family
HCV85_025525	COG4191	Histidine kinase
HCV85_025530	COG3678	ATP-independent chaperone mediated protein folding
HCV85_025565	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HCV85_025580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCV85_025585	COG2104	thiamine diphosphate biosynthetic process
HCV85_025600	COG3706	GGDEF domain
HCV85_025610	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCV85_025615	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HCV85_025650	COG0250	Participates in transcription elongation, termination and antitermination
HCV85_025695	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HCV85_025725	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HCV85_025735	COG1739	Uncharacterized protein family UPF0029
HCV85_025775	COG0805	protein transport
HCV85_025795	COG3165	ubiquinone biosynthetic process from chorismate
HCV85_025825	COG0583	DNA-binding transcription factor activity
HCV85_025830	COG0697	spore germination
HCV85_025835	COG0561	phosphatase activity
HCV85_025840	COG2267	carboxylic ester hydrolase activity
HCV85_025845	COG1280	lysine exporter protein (LysE YggA)
HCV85_025855	COG1280	lysine exporter protein (LysE YggA)
HCV85_025885	COG0210	DNA helicase
HCV85_025890	COG1011	Hydrolase
HCV85_025920	COG3072	Adenylate cyclase
HCV85_025935	COG2959	enzyme of heme biosynthesis
HCV85_025940	COG3071	HemY protein
HCV85_025985	COG2244	polysaccharide biosynthetic process
HCV85_025990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCV85_025995	COG0456	acetyltransferase
HCV85_026000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HCV85_026005	COG1088	dTDP-glucose 4,6-dehydratase activity
HCV85_026010	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HCV85_026015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCV85_026025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCV85_026030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HCV85_026035	COG3118	belongs to the thioredoxin family
HCV85_026060	COG1811	Na channel or pump
HCV85_026070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCV85_026075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCV85_026085	COG0583	DNA-binding transcription factor activity
HCV85_026090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCV85_026105	COG3978	acetolactate synthase activity
HCV85_026125	COG3085	chromosome segregation
HCV85_026200	COG0583	DNA-binding transcription factor activity
HCV85_026215	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HCV85_026230	COG3443	Belongs to the bacterial solute-binding protein 9 family
HCV85_026235	COG2207	Transcriptional regulator
HCV85_026245	COG0371	Dehydrogenase
HCV85_026250	COG0697	spore germination
HCV85_026260	COG0583	DNA-binding transcription factor activity
HCV85_026270	COG0737	Belongs to the 5'-nucleotidase family
HCV85_026280	COG0527	aspartate kinase activity
HCV85_026280	COG0460	homoserine dehydrogenase
HCV85_026285	COG0626	cystathionine gamma-synthase activity
HCV85_026300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCV85_026305	COG1609	Transcriptional regulator
HCV85_026310	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCV85_026325	COG1575	Belongs to the MenA family. Type 1 subfamily
HCV85_026345	COG3678	ATP-independent chaperone mediated protein folding
HCV85_026350	COG0745	RESPONSE REGULATOR receiver
HCV85_026355	COG2205	protein histidine kinase activity
HCV85_026360	COG2258	MOSC domain
HCV85_026365	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCV85_026405	COG1129	ABC transporter
HCV85_026410	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV85_026415	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV85_026420	COG1454	alcohol dehydrogenase
HCV85_026430	COG2211	Major facilitator Superfamily
HCV85_026490	COG0205	6-phosphofructokinase activity
HCV85_026510	COG0437	4 iron, 4 sulfur cluster binding
HCV85_026515	COG2864	formate dehydrogenase
HCV85_026530	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HCV85_026535	COG0657	acetylesterase activity
HCV85_026540	COG0456	acetyltransferase
HCV85_026555	COG1011	Hydrolase
HCV85_026570	COG3852	Histidine kinase
HCV85_026585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCV85_026605	COG0204	Acyl-transferase
HCV85_026615	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCV85_026620	COG3084	Protein conserved in bacteria
HCV85_026630	COG1763	Mo-molybdopterin cofactor biosynthetic process
HCV85_026655	COG2186	Transcriptional regulator
HCV85_026660	COG0477	Major facilitator Superfamily
HCV85_026665	COG1609	Transcriptional regulator
HCV85_026670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCV85_026680	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCV85_026685	COG1129	ABC transporter
HCV85_026715	COG1522	sequence-specific DNA binding
HCV85_026720	COG0716	FMN binding
HCV85_026735	COG3312	ion transport
HCV85_026785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCV85_026790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCV85_026795	COG0573	inorganic phosphate transmembrane transporter activity
HCV85_026800	COG0581	inorganic phosphate transmembrane transporter activity
HCV85_026805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCV85_026810	COG0704	Plays a role in the regulation of phosphate uptake
HCV85_026820	COG2382	esterase
HCV85_026825	COG0363	glucosamine-6-phosphate deaminase activity
HCV85_026830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCV85_026835	COG2252	PERMEase
HCV85_026840	COG0431	NADPH-dependent FMN reductase
HCV85_026845	COG2091	lysine biosynthetic process via aminoadipic acid
HCV85_026875	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HCV85_026900	COG2203	Gaf domain
HCV85_026900	COG2199	diguanylate cyclase activity
HCV85_026905	COG5001	Diguanylate cyclase
HCV85_026905	COG1716	ATPase activity
HCV85_026920	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HCV85_026930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HCV85_026975	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCV85_027005	COG0739	heme binding
HCV85_027015	COG2132	Multicopper oxidase
HCV85_027020	COG3667	copper resistance
HCV85_027025	COG2372	response to copper ion
HCV85_027030	COG1276	copper resistance
HCV85_027035	COG0745	RESPONSE REGULATOR receiver
HCV85_027040	COG2205	protein histidine kinase activity
HCV85_027060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HCV85_027075	COG0431	NADPH-dependent FMN reductase
HCV85_027105	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCV85_027170	COG2801	Transposase and inactivated derivatives
HCV85_027180	COG0501	Belongs to the peptidase M48B family
HCV85_027195	COG0542	response to heat
HCV85_027200	COG0071	Belongs to the small heat shock protein (HSP20) family
HCV85_027280	COG1349	DNA-binding transcription factor activity
HCV85_027285	COG2084	Dehydrogenase
HCV85_027345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCV85_027350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCV85_027380	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HCV85_027495	COG0484	heat shock protein binding
HCV85_027535	COG1192	Involved in chromosome partitioning
HCV85_027575	COG3173	Aminoglycoside phosphotransferase
HCV85_027600	COG1695	Transcriptional regulator
HCV85_027825	COG5499	transcription regulator containing HTH domain
HCV85_027895	COG1475	DNA binding
HCV85_027950	COG3344	reverse transcriptase
HCV85_028010	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HCV85_028120	COG5001	Diguanylate cyclase
HCV85_028120	COG3300	MHYT domain
HCV85_028160	COG4644	lycopene metabolic process
HCV85_028185	COG5433	transposase activity
HCV85_028215	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HCV85_028285	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HCV85_028545	COG1475	DNA binding