locus-tag	class	description
I5M57_00020	COG3085	chromosome segregation
I5M57_00040	COG3978	acetolactate synthase activity
I5M57_00055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5M57_00060	COG0583	DNA-binding transcription factor activity
I5M57_00070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M57_00075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M57_00085	COG1811	Na channel or pump
I5M57_00110	COG3118	belongs to the thioredoxin family
I5M57_00115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I5M57_00120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5M57_00130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5M57_00135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I5M57_00140	COG1088	dTDP-glucose 4,6-dehydratase activity
I5M57_00145	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I5M57_00150	COG0456	acetyltransferase
I5M57_00155	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I5M57_00160	COG2244	polysaccharide biosynthetic process
I5M57_00205	COG3071	HemY protein
I5M57_00210	COG2959	enzyme of heme biosynthesis
I5M57_00225	COG3072	Adenylate cyclase
I5M57_00255	COG1011	Hydrolase
I5M57_00260	COG0210	DNA helicase
I5M57_00290	COG1280	lysine exporter protein (LysE YggA)
I5M57_00300	COG1280	lysine exporter protein (LysE YggA)
I5M57_00305	COG2267	carboxylic ester hydrolase activity
I5M57_00310	COG0561	phosphatase activity
I5M57_00315	COG0697	spore germination
I5M57_00320	COG0583	DNA-binding transcription factor activity
I5M57_00350	COG3165	ubiquinone biosynthetic process from chorismate
I5M57_00370	COG0805	protein transport
I5M57_00410	COG1739	Uncharacterized protein family UPF0029
I5M57_00420	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I5M57_00450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I5M57_00495	COG0250	Participates in transcription elongation, termination and antitermination
I5M57_00530	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I5M57_00535	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M57_00545	COG3706	GGDEF domain
I5M57_00560	COG2104	thiamine diphosphate biosynthetic process
I5M57_00565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5M57_00580	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I5M57_00615	COG3678	ATP-independent chaperone mediated protein folding
I5M57_00620	COG4191	Histidine kinase
I5M57_00630	COG0151	Belongs to the GarS family
I5M57_00660	COG0456	acetyltransferase
I5M57_00670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5M57_00700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5M57_00755	COG0527	aspartate kinase activity
I5M57_00765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I5M57_00775	COG0251	oxidation-reduction process
I5M57_00845	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I5M57_00855	COG0534	Mate efflux family protein
I5M57_00865	COG3237	CsbD-like
I5M57_00870	COG0735	belongs to the Fur family
I5M57_00880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5M57_00895	COG0305	Participates in initiation and elongation during chromosome replication
I5M57_00900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I5M57_00915	COG0432	Pfam Uncharacterised protein family UPF0047
I5M57_00920	COG2315	Protein conserved in bacteria
I5M57_00935	COG0741	lytic transglycosylase activity
I5M57_00940	COG4771	TonB-dependent receptor
I5M57_00960	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M57_00970	COG0483	inositol monophosphate 1-phosphatase activity
I5M57_00975	COG1609	Transcriptional regulator
I5M57_00980	COG1234	tRNA 3'-trailer cleavage
I5M57_01010	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5M57_01020	COG0789	Transcriptional regulator
I5M57_01025	COG0625	glutathione transferase activity
I5M57_01030	COG2252	PERMEase
I5M57_01035	COG0025	NhaP-type Na H and K H
I5M57_01040	COG0583	DNA-binding transcription factor activity
I5M57_01045	COG1380	Effector of murein hydrolase LrgA
I5M57_01050	COG1346	cytolysis
I5M57_01055	COG3539	Fimbrial protein
I5M57_01085	COG3162	membrane
I5M57_01090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5M57_01100	COG1301	dicarboxylic acid transport
I5M57_01105	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I5M57_01140	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M57_01145	COG1129	ABC transporter
I5M57_01150	COG0784	Response regulator, receiver
I5M57_01150	COG4191	Histidine kinase
I5M57_01160	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5M57_01170	COG3454	Phosphonate metabolism
I5M57_01175	COG4778	phosphonate C-P lyase system protein PhnL
I5M57_01180	COG4107	phosphonate C-P lyase system protein PhnK
I5M57_01185	COG3627	carbon phosphorus lyase activity
I5M57_01190	COG3626	phosphonate metabolism
I5M57_01195	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I5M57_01200	COG3624	Phosphonate C-P lyase system protein PhnG
I5M57_01205	COG2188	Transcriptional regulator
I5M57_01210	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I5M57_01215	COG2824	Alkylphosphonate utilization operon protein PhnA
I5M57_01225	COG2169	Transcriptional regulator
I5M57_01230	COG1486	melibiose metabolic process
I5M57_01275	COG0861	Integral membrane protein TerC family
I5M57_01290	COG1215	transferase activity, transferring glycosyl groups
I5M57_01295	COG0726	polysaccharide deacetylase
I5M57_01295	COG1649	PFAM Uncharacterised BCR, COG1649
I5M57_01300	COG0457	Tetratricopeptide repeat
I5M57_01330	COG1309	transcriptional regulator
I5M57_01345	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I5M57_01350	COG1027	Aspartate ammonia-lyase
I5M57_01355	COG3030	protein affecting phage T7 exclusion by the F plasmid
I5M57_01360	COG0531	amino acid
I5M57_01440	COG1509	lysine 2,3-aminomutase activity
I5M57_01455	COG5510	response to toxic substance
I5M57_01460	COG2076	Multidrug Resistance protein
I5M57_01480	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5M57_01485	COG1053	succinate dehydrogenase
I5M57_01500	COG1511	domain protein
I5M57_01500	COG3264	Mechanosensitive ion channel
I5M57_01520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M57_01540	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I5M57_01545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I5M57_01545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I5M57_01550	COG0802	atpase or kinase
I5M57_01555	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5M57_01575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5M57_01580	COG0330	HflC and HflK could
I5M57_01585	COG0330	HflC and HflK could
I5M57_01595	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I5M57_01610	COG0557	exoribonuclease II activity
I5M57_01615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M57_01620	COG1960	acyl-CoA dehydrogenase activity
I5M57_01630	COG3650	response to hydrogen peroxide
I5M57_01635	COG1073	alpha beta
I5M57_01695	COG2965	DNA replication, synthesis of RNA primer
I5M57_01700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I5M57_01710	COG3061	Opacity-associated protein A
I5M57_01715	COG0545	Peptidyl-prolyl cis-trans isomerase
I5M57_01720	COG1113	amino acid transport
I5M57_01730	COG0697	spore germination
I5M57_01740	COG0702	epimerase
I5M57_01745	COG1733	regulation of RNA biosynthetic process
I5M57_01760	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I5M57_01775	COG1253	flavin adenine dinucleotide binding
I5M57_01785	COG0729	surface antigen
I5M57_01790	COG2911	Protein conserved in bacteria
I5M57_01795	COG2105	PFAM AIG2 family protein
I5M57_01815	COG1879	ABC-type sugar transport system periplasmic component
I5M57_01820	COG1129	ABC transporter
I5M57_01825	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M57_01830	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M57_01840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5M57_01865	COG0312	modulator of DNA gyrase
I5M57_01905	COG3964	amidohydrolase
I5M57_01920	COG2706	6-phosphogluconolactonase activity
I5M57_01925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_01925	COG3711	transcriptional antiterminator
I5M57_01930	COG3077	Addiction module antitoxin, RelB DinJ family
I5M57_01935	COG2026	Addiction module toxin, RelE StbE family
I5M57_01940	COG0602	queuosine metabolic process
I5M57_01965	COG1486	melibiose metabolic process
I5M57_01970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M57_01975	COG0366	Alpha amylase catalytic
I5M57_01980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M57_01980	COG1263	PTS System
I5M57_02015	COG2731	YhcH YjgK YiaL family protein
I5M57_02020	COG2222	sugar isomerase
I5M57_02025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M57_02030	COG1228	amidohydrolase
I5M57_02035	COG1288	antiporter activity
I5M57_02040	COG2188	Transcriptional regulator
I5M57_02065	COG0525	valine-tRNA ligase activity
I5M57_02070	COG2927	DNA polymerase III (CHI subunit)
I5M57_02080	COG0795	lipopolysaccharide-transporting ATPase activity
I5M57_02085	COG0795	lipopolysaccharide-transporting ATPase activity
I5M57_02090	COG0433	COG0433 Predicted ATPase
I5M57_02105	COG3718	enzyme involved in inositol metabolism
I5M57_02110	COG0837	glucose binding
I5M57_02110	COG1737	Transcriptional regulator
I5M57_02115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M57_02120	COG3962	Belongs to the TPP enzyme family
I5M57_02130	COG1082	Xylose isomerase domain protein TIM barrel
I5M57_02140	COG1653	transport
I5M57_02145	COG3842	ATPase activity
I5M57_02150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5M57_02155	COG0395	ABC-type sugar transport system, permease component
I5M57_02160	COG1175	transmembrane transport
I5M57_02165	COG1064	alcohol dehydrogenase
I5M57_02170	COG0659	secondary active sulfate transmembrane transporter activity
I5M57_02175	COG0288	reversible hydration of carbon dioxide
I5M57_02185	COG0582	viral genome integration into host DNA
I5M57_02195	COG3039	Transposase
I5M57_02305	COG3507	Belongs to the glycosyl hydrolase 43 family
I5M57_02310	COG2211	Major facilitator Superfamily
I5M57_02320	COG4580	involved in the transport of maltose and maltodextrins
I5M57_02325	COG3272	Protein of unknown function (DUF1722)
I5M57_02345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5M57_02360	COG0300	oxidoreductase activity
I5M57_02370	COG0789	Transcriptional regulator
I5M57_02375	COG3040	lipid binding
I5M57_02385	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M57_02390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M57_02395	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M57_02400	COG1538	Outer membrane efflux protein
I5M57_02405	COG0745	RESPONSE REGULATOR receiver
I5M57_02410	COG5002	protein histidine kinase activity
I5M57_02425	COG2850	peptidyl-arginine hydroxylation
I5M57_02455	COG0842	Transport permease protein
I5M57_02460	COG1129	ABC transporter
I5M57_02460	COG0842	Transport permease protein
I5M57_02465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M57_02475	COG1879	ABC-type sugar transport system periplasmic component
I5M57_02480	COG1129	ABC transporter
I5M57_02485	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M57_02495	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5M57_02500	COG0583	DNA-binding transcription factor activity
I5M57_02510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M57_02515	COG5457	Domain of unknown function (DUF1127)
I5M57_02525	COG1566	PFAM secretion protein HlyD family protein
I5M57_02540	COG1924	4 iron, 4 sulfur cluster binding
I5M57_02545	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I5M57_02560	COG2733	membrane
I5M57_02570	COG1917	Cupin 2, conserved barrel domain protein
I5M57_02570	COG2207	Transcriptional regulator
I5M57_02575	COG5464	transposase or invertase
I5M57_02580	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_02590	COG0523	cobalamin synthesis protein
I5M57_02595	COG2879	small protein
I5M57_02600	COG1966	Carbon starvation protein
I5M57_02615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5M57_02620	COG2368	4-hydroxyphenylacetate
I5M57_02640	COG3971	2-oxopent-4-enoate hydratase activity
I5M57_02650	COG3384	dioxygenase
I5M57_02655	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_02665	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5M57_02675	COG1846	Transcriptional regulator
I5M57_02705	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I5M57_02720	COG3734	2-keto-3-deoxy-galactonokinase
I5M57_02725	COG0800	Aldolase
I5M57_02730	COG1737	Transcriptional regulator
I5M57_02740	COG0456	acetyltransferase
I5M57_02740	COG1214	PFAM Peptidase M22, glycoprotease
I5M57_02745	COG2271	Major facilitator Superfamily
I5M57_02750	COG1802	Transcriptional regulator
I5M57_02755	COG1063	alcohol dehydrogenase
I5M57_02765	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5M57_02765	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I5M57_02780	COG3715	PTS system
I5M57_02785	COG3716	PTS system mannose fructose sorbose family IID component
I5M57_02790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5M57_02800	COG5464	transposase or invertase
I5M57_02815	COG1484	DNA-dependent DNA replication
I5M57_02830	COG2966	Psort location CytoplasmicMembrane, score
I5M57_02845	COG2197	response regulator
I5M57_02850	COG2197	response regulator
I5M57_02855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5M57_02860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M57_02860	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M57_02865	COG4114	ferric iron reductase
I5M57_02870	COG3706	GGDEF domain
I5M57_02905	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I5M57_02910	COG0456	acetyltransferase
I5M57_02915	COG1011	Hydrolase
I5M57_02925	COG2823	Periplasmic or secreted lipoprotein
I5M57_02935	COG4667	esterase of the alpha-beta hydrolase superfamily
I5M57_02940	COG0084	hydrolase, TatD family'
I5M57_02945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M57_02975	COG3726	membrane protein affecting hemolysin expression
I5M57_02980	COG0560	Phosphoserine phosphatase
I5M57_02985	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I5M57_02995	COG0488	(ABC) transporter
I5M57_03000	COG0741	lytic transglycosylase activity
I5M57_03020	COG3708	Transcriptional regulator
I5M57_03020	COG2207	Transcriptional regulator
I5M57_03025	COG3045	CreA protein
I5M57_03030	COG0745	RESPONSE REGULATOR receiver
I5M57_03035	COG2205	protein histidine kinase activity
I5M57_03040	COG4452	Inner membrane protein CreD
I5M57_03045	COG0745	RESPONSE REGULATOR receiver
I5M57_03055	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I5M57_03065	COG0460	homoserine dehydrogenase
I5M57_03065	COG0527	aspartate kinase activity
I5M57_03075	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I5M57_03090	COG1115	amino acid carrier protein
I5M57_03095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5M57_03100	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5M57_03105	COG0477	Major facilitator Superfamily
I5M57_03110	COG1584	GPR1 FUN34 yaaH family protein
I5M57_03115	COG4735	regulation of single-species biofilm formation
I5M57_03140	COG0583	DNA-binding transcription factor activity
I5M57_03150	COG0196	riboflavin kinase activity
I5M57_03165	COG1047	Peptidyl-prolyl cis-trans
I5M57_03190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I5M57_03255	COG0505	Belongs to the CarA family
I5M57_03300	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I5M57_03310	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I5M57_03315	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I5M57_03330	COG3493	citrate carrier protein
I5M57_03340	COG0564	pseudouridine synthase activity
I5M57_03350	COG0417	DNA replication proofreading
I5M57_03355	COG0235	Class ii aldolase
I5M57_03375	COG0586	Pfam SNARE associated Golgi protein
I5M57_03385	COG1178	ABC-type Fe3 transport system permease component
I5M57_03405	COG2814	Major facilitator Superfamily
I5M57_03410	COG2271	Major facilitator Superfamily
I5M57_03415	COG0583	DNA-binding transcription factor activity
I5M57_03425	COG0738	Major facilitator superfamily
I5M57_03470	COG0028	Belongs to the TPP enzyme family
I5M57_03480	COG1609	Transcriptional regulator
I5M57_03500	COG0768	penicillin binding
I5M57_03505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I5M57_03510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5M57_03525	COG0772	Belongs to the SEDS family
I5M57_03550	COG0849	cell division
I5M57_03555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I5M57_03575	COG0494	nUDIX hydrolase
I5M57_03600	COG1459	type II secretion system
I5M57_03605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5M57_03610	COG4969	Belongs to the N-Me-Phe pilin family
I5M57_03620	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5M57_03625	COG3725	Membrane protein required for beta-lactamase induction
I5M57_03630	COG3940	Belongs to the glycosyl hydrolase 43 family
I5M57_03635	COG2211	Major facilitator Superfamily
I5M57_03640	COG1113	amino acid transport
I5M57_03645	COG2186	Transcriptional regulator
I5M57_03650	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I5M57_03655	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5M57_03660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M57_03675	COG3064	Membrane
I5M57_03725	COG2132	Multicopper oxidase
I5M57_03730	COG4993	Dehydrogenase
I5M57_03745	COG0288	reversible hydration of carbon dioxide
I5M57_03750	COG1131	(ABC) transporter
I5M57_03755	COG0842	Transport permease protein
I5M57_03760	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_03765	COG0726	polysaccharide deacetylase
I5M57_03785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5M57_03790	COG0617	tRNA 3'-terminal CCA addition
I5M57_03810	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I5M57_03815	COG1643	Atp-dependent helicase
I5M57_03910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5M57_03920	COG1120	ATPase activity
I5M57_03925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5M57_03930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M57_03950	COG2860	membrane
I5M57_03970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5M57_03975	COG3835	regulator
I5M57_03990	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I5M57_03995	COG0024	Methionine aminopeptidase
I5M57_04020	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I5M57_04030	COG0575	Belongs to the CDS family
I5M57_04035	COG0750	zinc metalloprotease
I5M57_04045	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I5M57_04085	COG1982	Orn Lys Arg decarboxylase major
I5M57_04090	COG0346	lactoylglutathione lyase activity
I5M57_04100	COG4568	rho-dependent transcription termination
I5M57_04115	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I5M57_04120	COG3015	lipoprotein NlpE involved in copper resistance
I5M57_04125	COG0791	NLP P60 protein
I5M57_04135	COG1720	tRNA m6t6A37 methyltransferase activity
I5M57_04145	COG1464	Belongs to the NlpA lipoprotein family
I5M57_04150	COG2011	ABC-type metal ion transport system permease component
I5M57_04160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I5M57_04195	COG0656	L-ascorbic acid biosynthetic process
I5M57_04200	COG0583	DNA-binding transcription factor activity
I5M57_04205	COG2814	Major facilitator Superfamily
I5M57_04215	COG2226	methyltransferase
I5M57_04220	COG1388	LysM domain
I5M57_04220	COG0741	lytic transglycosylase activity
I5M57_04230	COG2226	methyltransferase
I5M57_04240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5M57_04250	COG0583	DNA-binding transcription factor activity
I5M57_04260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5M57_04265	COG1960	acyl-CoA dehydrogenase activity
I5M57_04275	COG0121	glutamine amidotransferase
I5M57_04280	COG3034	peptidoglycan biosynthetic process
I5M57_04295	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I5M57_04300	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I5M57_04315	COG2991	Protein conserved in bacteria
I5M57_04330	COG0454	-acetyltransferase
I5M57_04335	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5M57_04355	COG1802	Transcriptional regulator
I5M57_04360	COG1113	amino acid transport
I5M57_04365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M57_04370	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_04375	COG0579	oxidoreductase
I5M57_04390	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I5M57_04395	COG0625	glutathione transferase activity
I5M57_04400	COG3775	system Galactitol-specific IIC component
I5M57_04405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M57_04410	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_04415	COG1070	Carbohydrate kinase
I5M57_04435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M57_04440	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5M57_04445	COG0022	dehydrogenase e1 component
I5M57_04450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5M57_04510	COG1192	Involved in chromosome partitioning
I5M57_04515	COG0582	viral genome integration into host DNA
I5M57_04540	COG0791	NLP P60 protein
I5M57_04560	COG3639	organic phosphonate transmembrane transporter activity
I5M57_04570	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I5M57_04595	COG3188	usher protein
I5M57_04610	COG0765	amino acid transport
I5M57_04615	COG0765	amino acid transport
I5M57_04620	COG1126	abc transporter atp-binding protein
I5M57_04625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M57_04665	COG4302	ethanolamine ammonia-lyase activity
I5M57_04670	COG4303	Ethanolamine ammonia lyase large subunit
I5M57_04685	COG0833	amino acid
I5M57_04690	COG2040	homocysteine
I5M57_04695	COG4521	taurine ABC transporter
I5M57_04700	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I5M57_04705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M57_04710	COG2175	clavaminate synthase activity
I5M57_04720	COG0113	porphobilinogen synthase activity
I5M57_04725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5M57_04730	COG1335	isochorismatase
I5M57_04735	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I5M57_04775	COG1785	Belongs to the alkaline phosphatase family
I5M57_04785	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I5M57_04795	COG3416	Protein conserved in bacteria
I5M57_04800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5M57_04810	COG4126	flavin adenine dinucleotide binding
I5M57_04825	COG1940	carbohydrate kinase activity
I5M57_04830	COG0419	ATPase involved in DNA repair
I5M57_04835	COG0420	3'-5' exonuclease activity
I5M57_04860	COG0366	Alpha amylase catalytic
I5M57_04865	COG0583	DNA-binding transcription factor activity
I5M57_04870	COG1335	isochorismatase
I5M57_04880	COG1228	amidohydrolase
I5M57_04890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M57_04905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_04915	COG0450	alkyl hydroperoxide reductase
I5M57_04940	COG1862	Preprotein translocase
I5M57_04945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5M57_04950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5M57_04970	COG4238	major outer membrane lipoprotein
I5M57_04980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5M57_04980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5M57_05000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I5M57_05005	COG0667	Aldo Keto reductase
I5M57_05015	COG0142	geranyltranstransferase activity
I5M57_05035	COG0693	protein deglycase activity
I5M57_05040	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5M57_05050	COG2814	Major facilitator Superfamily
I5M57_05055	COG0673	inositol 2-dehydrogenase activity
I5M57_05070	COG1053	succinate dehydrogenase
I5M57_05080	COG1053	succinate dehydrogenase
I5M57_05085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5M57_05090	COG1414	Transcriptional regulator
I5M57_05105	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I5M57_05110	COG1845	cytochrome c oxidase, subunit III
I5M57_05115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5M57_05120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5M57_05125	COG2223	nitrite transmembrane transporter activity
I5M57_05130	COG3056	Lipoprotein
I5M57_05135	COG0271	Belongs to the BolA IbaG family
I5M57_05155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5M57_05160	COG0776	regulation of translation
I5M57_05165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M57_05170	COG1555	photosystem II stabilization
I5M57_05175	COG0824	Thioesterase
I5M57_05185	COG4533	DNA binding
I5M57_05200	COG1522	sequence-specific DNA binding
I5M57_05205	COG1132	(ABC) transporter
I5M57_05210	COG1132	(ABC) transporter
I5M57_05215	COG0347	Belongs to the P(II) protein family
I5M57_05220	COG0004	ammonium transporteR
I5M57_05225	COG1946	Acyl-CoA thioesterase
I5M57_05230	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I5M57_05235	COG3695	enzyme binding
I5M57_05265	COG2364	Membrane
I5M57_05280	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5M57_05290	COG2182	Extracellular solute-binding protein
I5M57_05295	COG1175	transmembrane transport
I5M57_05300	COG3833	ABC-type maltose transport systems, permease component
I5M57_05305	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I5M57_05310	COG1874	Beta-galactosidase
I5M57_05360	COG0110	maltose O-acetyltransferase activity
I5M57_05375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M57_05380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M57_05390	COG3039	Transposase
I5M57_05400	COG3264	Mechanosensitive ion channel
I5M57_05400	COG1196	nuclear chromosome segregation
I5M57_05405	COG5464	transposase or invertase
I5M57_05415	COG3923	Primosomal replication protein n
I5M57_05420	COG2832	Protein of unknown function (DUF454)
I5M57_05460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M57_05465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5M57_05465	COG4651	solute:proton antiporter activity
I5M57_05470	COG2223	nitrite transmembrane transporter activity
I5M57_05480	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5M57_05485	COG3735	TraB family
I5M57_05500	COG1585	Membrane protein implicated in regulation of membrane protease activity
I5M57_05505	COG0330	HflC and HflK could
I5M57_05510	COG4619	ABC transporter
I5M57_05515	COG0390	transport system, permease component
I5M57_05520	COG3118	belongs to the thioredoxin family
I5M57_05525	COG0300	oxidoreductase activity
I5M57_05530	COG2755	lipolytic protein G-D-S-L family
I5M57_05535	COG4181	ATPase activity
I5M57_05540	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I5M57_05560	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I5M57_05565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I5M57_05580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I5M57_05590	COG2501	S4 domain
I5M57_05805	COG3772	lysozyme
I5M57_05815	COG3646	Phage regulatory protein
I5M57_05975	COG3344	reverse transcriptase
I5M57_06025	COG3539	Fimbrial protein
I5M57_06030	COG3121	Chaperone
I5M57_06035	COG3188	usher protein
I5M57_06050	COG1560	Kdo2-lipid A biosynthetic process
I5M57_06060	COG3710	Transcriptional regulator
I5M57_06065	COG0531	amino acid
I5M57_06070	COG1982	Orn Lys Arg decarboxylase major
I5M57_06075	COG3104	oligopeptide transport
I5M57_06105	COG0673	inositol 2-dehydrogenase activity
I5M57_06120	COG1129	ABC transporter
I5M57_06125	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M57_06170	COG1566	PFAM secretion protein HlyD family protein
I5M57_06175	COG1120	ATPase activity
I5M57_06180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M57_06210	COG1473	amidohydrolase
I5M57_06215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M57_06220	COG0667	Aldo Keto reductase
I5M57_06265	COG0531	amino acid
I5M57_06275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5M57_06280	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_06295	COG1113	amino acid transport
I5M57_06300	COG2211	Major facilitator Superfamily
I5M57_06310	COG0673	inositol 2-dehydrogenase activity
I5M57_06320	COG2771	luxR family
I5M57_06335	COG3188	usher protein
I5M57_06365	COG0668	transmembrane transport
I5M57_06370	COG0477	Major facilitator Superfamily
I5M57_06385	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I5M57_06385	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5M57_06390	COG2222	sugar isomerase
I5M57_06395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5M57_06400	COG3716	PTS system mannose fructose sorbose family IID component
I5M57_06410	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M57_06420	COG0778	Nitroreductase
I5M57_06425	COG2315	Protein conserved in bacteria
I5M57_06475	COG3698	Phosphodiester glycosidase
I5M57_06485	COG0697	spore germination
I5M57_06500	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I5M57_06505	COG0765	amino acid transport
I5M57_06510	COG4215	(ABC) transporter
I5M57_06520	COG4221	oxidoreductase activity
I5M57_06525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5M57_06530	COG4608	Belongs to the ABC transporter superfamily
I5M57_06535	COG0444	Belongs to the ABC transporter superfamily
I5M57_06540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M57_06545	COG0601	transmembrane transport
I5M57_06550	COG0747	negative chemotaxis
I5M57_06575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5M57_06585	COG0668	transmembrane transport
I5M57_06590	COG0583	DNA-binding transcription factor activity
I5M57_06600	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_06610	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M57_06615	COG1129	ABC transporter
I5M57_06625	COG1879	ABC-type sugar transport system periplasmic component
I5M57_06630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5M57_06635	COG2390	Transcriptional regulator
I5M57_06640	COG3959	Transketolase, thiamine diphosphate binding domain
I5M57_06645	COG3958	Transketolase
I5M57_06650	COG2977	Belongs to the P-Pant transferase superfamily
I5M57_06655	COG4771	TonB-dependent receptor
I5M57_06660	COG2382	esterase
I5M57_06665	COG3251	PFAM MbtH domain protein
I5M57_06670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5M57_06670	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I5M57_06675	COG1120	ATPase activity
I5M57_06680	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M57_06685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M57_06695	COG4592	Periplasmic binding protein
I5M57_06700	COG1169	isochorismate synthase
I5M57_06705	COG1021	2,3-dihydroxybenzoate-AMP ligase
I5M57_06710	COG3433	isochorismatase activity
I5M57_06710	COG1535	isochorismatase
I5M57_06715	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_06725	COG1966	Carbon starvation protein
I5M57_06730	COG2879	small protein
I5M57_06745	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_06750	COG0371	Dehydrogenase
I5M57_06755	COG1129	ABC transporter
I5M57_06760	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M57_06790	COG2271	Major facilitator Superfamily
I5M57_06795	COG0483	inositol monophosphate 1-phosphatase activity
I5M57_06805	COG0402	S-adenosylhomocysteine deaminase activity
I5M57_06815	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5M57_06830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M57_06840	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M57_06845	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M57_06850	COG1129	ABC transporter
I5M57_06875	COG0436	Aminotransferase
I5M57_06880	COG1475	DNA binding
I5M57_06885	COG3969	phosphoadenosine phosphosulfate
I5M57_06890	COG0583	DNA-binding transcription factor activity
I5M57_06895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5M57_06915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5M57_06920	COG3719	Belongs to the RNase T2 family
I5M57_06925	COG3069	C4-dicarboxylate transmembrane transporter activity
I5M57_06945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5M57_06960	COG0583	DNA-binding transcription factor activity
I5M57_06975	COG1686	Belongs to the peptidase S11 family
I5M57_06980	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5M57_06985	COG0772	Belongs to the SEDS family
I5M57_06990	COG0768	penicillin binding
I5M57_07000	COG0799	negative regulation of ribosome biogenesis
I5M57_07015	COG1466	dna polymerase III delta subunit
I5M57_07030	COG2888	peptidyl-tyrosine sulfation
I5M57_07045	COG1126	abc transporter atp-binding protein
I5M57_07050	COG0765	amino acid transport
I5M57_07055	COG0765	amino acid transport
I5M57_07070	COG4535	Mg2 and Co2 transporter CorC
I5M57_07080	COG1702	phosphate starvation-inducible protein PhoH
I5M57_07090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M57_07130	COG0367	asparagine synthase
I5M57_07135	COG0647	UMP catabolic process
I5M57_07140	COG1940	carbohydrate kinase activity
I5M57_07140	COG1846	Transcriptional regulator
I5M57_07145	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I5M57_07185	COG0735	belongs to the Fur family
I5M57_07200	COG0596	Alpha beta hydrolase
I5M57_07210	COG0033	Phosphoglucomutase
I5M57_07220	COG0745	RESPONSE REGULATOR receiver
I5M57_07225	COG2205	protein histidine kinase activity
I5M57_07255	COG0415	Belongs to the DNA photolyase family
I5M57_07270	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I5M57_07275	COG1984	allophanate hydrolase subunit 2
I5M57_07310	COG2009	succinate dehydrogenase
I5M57_07315	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I5M57_07320	COG1053	succinate dehydrogenase
I5M57_07325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5M57_07330	COG0567	Dehydrogenase, E1 component
I5M57_07335	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5M57_07345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5M57_07350	COG1271	oxidase subunit
I5M57_07355	COG1294	oxidase, subunit
I5M57_07360	COG4890	Cyd operon protein YbgT
I5M57_07365	COG3790	cyd operon protein YbgE
I5M57_07370	COG0824	Thioesterase
I5M57_07375	COG0811	peptide transport
I5M57_07380	COG0848	biopolymer transport protein
I5M57_07385	COG3064	Membrane
I5M57_07395	COG2885	chlorophyll binding
I5M57_07400	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I5M57_07440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I5M57_07445	COG3201	nicotinamide mononucleotide transporter
I5M57_07460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M57_07470	COG2017	converts alpha-aldose to the beta-anomer
I5M57_07480	COG1085	galactose-1-phosphate uridylyltransferase
I5M57_07490	COG1119	ATPase activity
I5M57_07495	COG2005	Transcriptional regulator
I5M57_07495	COG3585	molybdate ion transport
I5M57_07505	COG0725	ABC transporter, periplasmic molybdate-binding protein
I5M57_07510	COG4149	molybdate abc transporter
I5M57_07515	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I5M57_07520	COG0561	phosphatase activity
I5M57_07545	COG2200	EAL domain
I5M57_07550	COG0789	Transcriptional regulator
I5M57_07585	COG4677	pectinesterase activity
I5M57_07625	COG1881	PFAM PEBP family protein
I5M57_07630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5M57_07645	COG2226	methyltransferase
I5M57_07670	COG0642	Histidine kinase
I5M57_07675	COG0745	RESPONSE REGULATOR receiver
I5M57_07695	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5M57_07705	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I5M57_07710	COG0314	molybdopterin synthase activity
I5M57_07715	COG0670	Belongs to the BI1 family
I5M57_07720	COG0392	lysyltransferase activity
I5M57_07725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M57_07730	COG3568	Endonuclease Exonuclease Phosphatase
I5M57_07740	COG0842	Transport permease protein
I5M57_07745	COG0842	Transport permease protein
I5M57_07750	COG1131	(ABC) transporter
I5M57_07755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M57_07760	COG1309	transcriptional regulator
I5M57_07765	COG0583	DNA-binding transcription factor activity
I5M57_07775	COG2271	Major facilitator Superfamily
I5M57_07780	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_07785	COG3959	Transketolase, thiamine diphosphate binding domain
I5M57_07790	COG3958	Transketolase
I5M57_07795	COG0513	Belongs to the DEAD box helicase family
I5M57_07800	COG1199	ATP-dependent helicase activity
I5M57_07805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5M57_07815	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5M57_07825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5M57_07835	COG0668	transmembrane transport
I5M57_07840	COG1126	abc transporter atp-binding protein
I5M57_07845	COG0765	amino acid transport
I5M57_07850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M57_07865	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I5M57_07870	COG2194	sulfuric ester hydrolase activity
I5M57_07880	COG1321	iron dependent repressor
I5M57_07885	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I5M57_07890	COG2723	6-phospho-beta-galactosidase activity
I5M57_07895	COG2188	Transcriptional regulator
I5M57_07900	COG1376	ErfK ybiS ycfS ynhG family protein
I5M57_07905	COG2365	Tyrosine phosphatase family
I5M57_07910	COG0488	(ABC) transporter
I5M57_07920	COG2271	Major facilitator Superfamily
I5M57_07925	COG1609	Transcriptional regulator
I5M57_07935	COG0561	phosphatase activity
I5M57_07940	COG1882	Formate acetyltransferase
I5M57_07945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5M57_07950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5M57_07955	COG0303	'Molybdopterin
I5M57_07970	COG0747	negative chemotaxis
I5M57_07990	COG2223	nitrite transmembrane transporter activity
I5M57_08000	COG2133	pyrroloquinoline quinone binding
I5M57_08005	COG0625	glutathione transferase activity
I5M57_08015	COG1686	Belongs to the peptidase S11 family
I5M57_08020	COG1349	DNA-binding transcription factor activity
I5M57_08025	COG0671	phosphoesterase, PA-phosphatase related
I5M57_08030	COG2814	Major facilitator Superfamily
I5M57_08035	COG0561	phosphatase activity
I5M57_08040	COG0738	Major facilitator superfamily
I5M57_08045	COG3226	Transcriptional regulator
I5M57_08050	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I5M57_08055	COG3344	reverse transcriptase
I5M57_08080	COG4695	Portal protein
I5M57_08275	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5M57_08280	COG3842	ATPase activity
I5M57_08285	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5M57_08290	COG1177	transmembrane transport
I5M57_08305	COG0745	RESPONSE REGULATOR receiver
I5M57_08310	COG5002	protein histidine kinase activity
I5M57_08315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M57_08320	COG4160	amino acid transport
I5M57_08325	COG4215	(ABC) transporter
I5M57_08330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M57_08335	COG1126	abc transporter atp-binding protein
I5M57_08345	COG2203	Gaf domain
I5M57_08345	COG3706	GGDEF domain
I5M57_08345	COG4251	negative regulation of phosphorylation
I5M57_08345	COG5001	Diguanylate cyclase
I5M57_08350	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5M57_08355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5M57_08360	COG0702	epimerase
I5M57_08365	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I5M57_08370	COG0028	Belongs to the TPP enzyme family
I5M57_08380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M57_08390	COG2431	L-lysine efflux transmembrane transporter activity
I5M57_08400	COG3593	DNA synthesis involved in DNA repair
I5M57_08405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M57_08415	COG1278	Cold shock
I5M57_08425	COG0542	response to heat
I5M57_08440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I5M57_08445	COG4988	ABC transporter
I5M57_08450	COG0492	ferredoxin-NADP+ reductase activity
I5M57_08460	COG1178	ABC-type Fe3 transport system permease component
I5M57_08460	COG1674	ftsk spoiiie
I5M57_08470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5M57_08480	COG0243	molybdopterin cofactor binding
I5M57_08485	COG0437	4 iron, 4 sulfur cluster binding
I5M57_08490	COG3302	dmso reductase anchor subunit
I5M57_08495	COG0477	Major facilitator Superfamily
I5M57_08500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5M57_08505	COG1882	Formate acetyltransferase
I5M57_08510	COG2116	formate transmembrane transporter activity
I5M57_08515	COG1944	ATP diphosphatase activity
I5M57_08520	COG2323	membrane
I5M57_08540	COG0539	negative regulation of cytoplasmic translation
I5M57_08550	COG0658	competence protein
I5M57_08550	COG2333	competence protein COMEC
I5M57_08565	COG3214	Protein conserved in bacteria
I5M57_08580	COG3173	Aminoglycoside phosphotransferase
I5M57_08585	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I5M57_08590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5M57_08600	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I5M57_08610	COG2989	Protein conserved in bacteria
I5M57_08615	COG3108	Peptidase M15
I5M57_08620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5M57_08625	COG1448	Aminotransferase
I5M57_08650	COG0814	amino acid
I5M57_08660	COG1473	amidohydrolase
I5M57_08670	COG0308	aminopeptidase N
I5M57_08680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M57_08685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M57_08690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M57_08695	COG0431	NADPH-dependent FMN reductase
I5M57_08710	COG3217	Mosc domain protein beta barrel domain protein
I5M57_08710	COG0633	Ferredoxin
I5M57_08720	COG0488	(ABC) transporter
I5M57_08725	COG2995	paraquat-inducible protein a
I5M57_08730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5M57_08730	COG3008	intermembrane lipid transfer
I5M57_08735	COG3009	Protein conserved in bacteria
I5M57_08740	COG3130	regulation of translation
I5M57_08750	COG1067	ATP-dependent peptidase activity
I5M57_08770	COG3070	regulator of competence-specific genes
I5M57_08775	COG1289	transmembrane transporter activity
I5M57_08780	COG3304	Inner membrane component domain
I5M57_08785	COG0210	DNA helicase
I5M57_08795	COG1832	CoA-binding protein
I5M57_08810	COG1881	PFAM PEBP family protein
I5M57_08815	COG2207	Transcriptional regulator
I5M57_08830	COG0670	Belongs to the BI1 family
I5M57_08855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M57_08860	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_08865	COG4638	Rieske (2fe-2S)
I5M57_08870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5M57_08875	COG0473	3-isopropylmalate dehydrogenase activity
I5M57_08880	COG0583	DNA-binding transcription factor activity
I5M57_08885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5M57_08890	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_08895	COG1396	sequence-specific DNA binding
I5M57_08895	COG1917	Cupin 2, conserved barrel domain protein
I5M57_08900	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5M57_08905	COG0174	glutamine synthetase
I5M57_08910	COG0531	amino acid
I5M57_08925	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_08955	COG3729	General stress protein
I5M57_08965	COG2233	PERMEase
I5M57_09000	COG1309	transcriptional regulator
I5M57_09015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5M57_09025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M57_09045	COG1702	phosphate starvation-inducible protein PhoH
I5M57_09050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5M57_09060	COG1335	isochorismatase
I5M57_09070	COG0583	DNA-binding transcription factor activity
I5M57_09100	COG3381	protein complex oligomerization
I5M57_09135	COG5645	(Lipo)protein
I5M57_09150	COG1560	Kdo2-lipid A biosynthetic process
I5M57_09195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M57_09215	COG2814	Major facilitator Superfamily
I5M57_09220	COG0583	DNA-binding transcription factor activity
I5M57_09225	COG1530	ribonuclease E activity
I5M57_09245	COG1399	metal-binding, possibly nucleic acid-binding protein
I5M57_09265	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5M57_09280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M57_09285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I5M57_09290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5M57_09300	COG0470	DNA polymerase III
I5M57_09305	COG0084	hydrolase, TatD family'
I5M57_09315	COG0537	adenosine 5'-monophosphoramidase activity
I5M57_09320	COG5633	Lipoprotein
I5M57_09345	COG1252	NADH dehydrogenase
I5M57_09350	COG3134	Outer membrane lipoprotein
I5M57_09365	COG1309	transcriptional regulator
I5M57_09380	COG1376	ErfK ybiS ycfS ynhG family protein
I5M57_09380	COG1388	LysM domain
I5M57_09385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I5M57_09395	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5M57_09405	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5M57_09415	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I5M57_09425	COG0318	PFAM AMP-dependent synthetase and ligase
I5M57_09440	COG1177	transmembrane transport
I5M57_09460	COG2850	peptidyl-arginine hydroxylation
I5M57_09465	COG2205	protein histidine kinase activity
I5M57_09485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5M57_09505	COG1187	pseudouridine synthase activity
I5M57_09510	COG0538	isocitrate dehydrogenase activity
I5M57_09515	COG0582	viral genome integration into host DNA
I5M57_09525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5M57_09545	COG1396	sequence-specific DNA binding
I5M57_09585	COG3344	reverse transcriptase
I5M57_09595	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I5M57_09600	COG3344	reverse transcriptase
I5M57_09620	COG1403	HNH endonuclease
I5M57_09645	COG3772	lysozyme
I5M57_09690	COG1802	Transcriptional regulator
I5M57_09690	COG4626	Terminase
I5M57_09705	COG0616	signal peptide processing
I5M57_09790	COG0538	isocitrate dehydrogenase activity
I5M57_09795	COG0640	Transcriptional regulator
I5M57_09815	COG3813	Protein conserved in bacteria
I5M57_09820	COG1063	alcohol dehydrogenase
I5M57_09825	COG3729	General stress protein
I5M57_09830	COG3685	Protein conserved in bacteria
I5M57_09835	COG3685	Protein conserved in bacteria
I5M57_09840	COG3546	catalase activity
I5M57_09845	COG1271	oxidase subunit
I5M57_09850	COG1294	oxidase, subunit
I5M57_09880	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I5M57_09885	COG0583	DNA-binding transcription factor activity
I5M57_09890	COG3706	GGDEF domain
I5M57_09895	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I5M57_09905	COG1560	Kdo2-lipid A biosynthetic process
I5M57_09915	COG3182	Iron-regulated membrane protein
I5M57_09935	COG2199	diguanylate cyclase activity
I5M57_09935	COG2203	Gaf domain
I5M57_09940	COG3042	response to heat
I5M57_09945	COG3189	MarR family transcriptional regulator
I5M57_09950	COG1683	Conserved Protein
I5M57_09955	COG0504	CTP synthase activity
I5M57_09960	COG2807	transmembrane transport
I5M57_09965	COG2207	Transcriptional regulator
I5M57_09975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5M57_09980	COG0859	PFAM glycosyl transferase family 9
I5M57_09990	COG3344	reverse transcriptase
I5M57_09995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5M57_10000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5M57_10005	COG0583	DNA-binding transcription factor activity
I5M57_10010	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_10035	COG0386	Belongs to the glutathione peroxidase family
I5M57_10050	COG2766	serine protein kinase
I5M57_10055	COG3713	MltA-interacting MipA family protein
I5M57_10080	COG3139	Protein of unknown function (DUF1315)
I5M57_10095	COG1063	alcohol dehydrogenase
I5M57_10100	COG2271	Major facilitator Superfamily
I5M57_10105	COG1063	alcohol dehydrogenase
I5M57_10110	COG0191	fructose-bisphosphate aldolase activity
I5M57_10115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M57_10120	COG0667	Aldo Keto reductase
I5M57_10125	COG1349	DNA-binding transcription factor activity
I5M57_10130	COG2814	Major facilitator Superfamily
I5M57_10135	COG1335	isochorismatase
I5M57_10140	COG0252	asparaginase activity
I5M57_10145	COG0616	signal peptide processing
I5M57_10150	COG0778	Nitroreductase
I5M57_10165	COG0709	Synthesizes selenophosphate from selenide and ATP
I5M57_10170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5M57_10175	COG3321	synthase
I5M57_10175	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_10175	COG0604	alcohol dehydrogenase
I5M57_10180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5M57_10185	COG0494	nUDIX hydrolase
I5M57_10190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I5M57_10195	COG2897	thiosulfate sulfurtransferase activity
I5M57_10200	COG4136	ATPase activity
I5M57_10205	COG4135	transport system, permease component
I5M57_10210	COG4134	Bacterial extracellular solute-binding protein
I5M57_10215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M57_10220	COG0398	Pfam SNARE associated Golgi protein
I5M57_10225	COG0398	Pfam SNARE associated Golgi protein
I5M57_10230	COG0708	Exodeoxyribonuclease III
I5M57_10240	COG3138	arginine N-succinyltransferase
I5M57_10250	COG3724	N-succinylarginine dihydrolase activity
I5M57_10260	COG3678	ATP-independent chaperone mediated protein folding
I5M57_10265	COG0322	excinuclease ABC activity
I5M57_10275	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M57_10280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M57_10295	COG3039	Transposase
I5M57_10305	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M57_10310	COG1917	Cupin 2, conserved barrel domain protein
I5M57_10310	COG2169	Transcriptional regulator
I5M57_10315	COG1486	melibiose metabolic process
I5M57_10325	COG0753	catalase activity
I5M57_10335	COG1823	symporter activity
I5M57_10340	COG1988	membrane-bound metal-dependent
I5M57_10345	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_10350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M57_10380	COG0727	PFAM Uncharacterised protein family (UPF0153)
I5M57_10385	COG3047	cAMP biosynthetic process
I5M57_10395	COG4774	siderophore transport
I5M57_10450	COG0134	indole-3-glycerol-phosphate synthase activity
I5M57_10450	COG0135	phosphoribosylanthranilate isomerase activity
I5M57_10455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5M57_10455	COG0512	Glutamine amidotransferase of anthranilate synthase
I5M57_10460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5M57_10470	COG0009	L-threonylcarbamoyladenylate synthase
I5M57_10480	COG0583	DNA-binding transcription factor activity
I5M57_10490	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I5M57_10495	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_10505	COG0616	signal peptide processing
I5M57_10530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I5M57_10540	COG0671	phosphoesterase, PA-phosphatase related
I5M57_10545	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I5M57_10550	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I5M57_10560	COG0023	Translation Initiation Factor
I5M57_10570	COG1349	DNA-binding transcription factor activity
I5M57_10585	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M57_10585	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M57_10590	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I5M57_10600	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5M57_10615	COG4171	peptide transport system, permease
I5M57_10730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5M57_10780	COG3344	reverse transcriptase
I5M57_10785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5M57_10790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5M57_10800	COG2135	peptidase activity
I5M57_10815	COG0702	epimerase
I5M57_10830	COG1473	amidohydrolase
I5M57_10840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5M57_10845	COG1842	Phage shock protein A
I5M57_10855	COG1983	PspC domain protein
I5M57_10865	COG3106	COG3106 Predicted ATPase
I5M57_10875	COG0583	DNA-binding transcription factor activity
I5M57_10880	COG1486	melibiose metabolic process
I5M57_10890	COG3180	Ammonia monooxygenase
I5M57_10895	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I5M57_10900	COG4948	Mandelate Racemase Muconate Lactonizing
I5M57_10905	COG2866	Carboxypeptidase
I5M57_10915	COG4166	transmembrane transport
I5M57_10945	COG0656	L-ascorbic acid biosynthetic process
I5M57_10960	COG0583	DNA-binding transcription factor activity
I5M57_10965	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_10970	COG1078	dGTPase activity
I5M57_10975	COG0693	protein deglycase activity
I5M57_10980	COG0582	viral genome integration into host DNA
I5M57_11085	COG0484	heat shock protein binding
I5M57_11095	COG3772	lysozyme
I5M57_11115	COG1783	phage Terminase large subunit
I5M57_11120	COG3567	Phage-associated protein, HI1409 family
I5M57_11190	COG0741	lytic transglycosylase activity
I5M57_11190	COG0739	heme binding
I5M57_11190	COG1196	nuclear chromosome segregation
I5M57_11275	COG3344	reverse transcriptase
I5M57_11315	COG2885	chlorophyll binding
I5M57_11410	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_11415	COG1309	transcriptional regulator
I5M57_11420	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_11440	COG0583	DNA-binding transcription factor activity
I5M57_11470	COG0604	alcohol dehydrogenase
I5M57_11475	COG0436	Aminotransferase
I5M57_11490	COG2011	ABC-type metal ion transport system permease component
I5M57_11495	COG1448	Aminotransferase
I5M57_11505	COG1522	sequence-specific DNA binding
I5M57_11510	COG1113	amino acid transport
I5M57_11525	COG0673	inositol 2-dehydrogenase activity
I5M57_11530	COG1349	DNA-binding transcription factor activity
I5M57_11540	COG0513	Belongs to the DEAD box helicase family
I5M57_11550	COG0589	response to stress
I5M57_11560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5M57_11565	COG1013	pyruvate-flavodoxin oxidoreductase activity
I5M57_11565	COG0674	pyruvate-flavodoxin oxidoreductase activity
I5M57_11565	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I5M57_11565	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5M57_11570	COG3042	response to heat
I5M57_11575	COG3187	Heat shock protein
I5M57_11580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5M57_11585	COG0586	Pfam SNARE associated Golgi protein
I5M57_11590	COG2911	Protein conserved in bacteria
I5M57_11600	COG3784	Protein of unknown function (DUF1318)
I5M57_11605	COG2207	Transcriptional regulator
I5M57_11610	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_11630	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_11630	COG2030	dehydratase
I5M57_11635	COG3396	Phenylacetate-CoA oxygenase
I5M57_11640	COG3460	Phenylacetate-CoA oxygenase
I5M57_11645	COG3396	Phenylacetate-CoA oxygenase
I5M57_11650	COG2151	metal-sulfur cluster biosynthetic enzyme
I5M57_11655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M57_11660	COG1024	Enoyl-CoA hydratase
I5M57_11665	COG1024	Enoyl-CoA hydratase
I5M57_11670	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5M57_11675	COG2050	protein possibly involved in aromatic compounds catabolism
I5M57_11680	COG0183	Belongs to the thiolase family
I5M57_11685	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I5M57_11690	COG3327	negative regulation of DNA-templated transcription, initiation
I5M57_11695	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5M57_11710	COG1643	Atp-dependent helicase
I5M57_11715	COG4122	O-methyltransferase activity
I5M57_11740	COG0583	DNA-binding transcription factor activity
I5M57_11745	COG0667	Aldo Keto reductase
I5M57_11750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5M57_11760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5M57_11765	COG3138	arginine N-succinyltransferase
I5M57_11770	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_11775	COG3724	N-succinylarginine dihydrolase activity
I5M57_11780	COG2988	succinylglutamate desuccinylase activity
I5M57_11785	COG1113	amino acid transport
I5M57_11790	COG0477	Major facilitator Superfamily
I5M57_11795	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I5M57_11805	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_11810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5M57_11815	COG0401	homolog of Blt101
I5M57_11820	COG5562	phage envelope protein
I5M57_11825	COG0425	Belongs to the sulfur carrier protein TusA family
I5M57_11830	COG2391	methyltransferase activity
I5M57_11855	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I5M57_11860	COG1263	PTS System
I5M57_11860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M57_11865	COG1609	Transcriptional regulator
I5M57_11870	COG5339	Protein conserved in bacteria
I5M57_11875	COG1482	cell wall glycoprotein biosynthetic process
I5M57_11880	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M57_11880	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M57_11885	COG0114	fumarate hydratase activity
I5M57_11895	COG2205	protein histidine kinase activity
I5M57_11905	COG0745	RESPONSE REGULATOR receiver
I5M57_11910	COG3136	membrane protein required for alginate biosynthesis
I5M57_11920	COG0531	amino acid
I5M57_11935	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I5M57_11940	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I5M57_11955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5M57_11970	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I5M57_11975	COG1473	amidohydrolase
I5M57_11985	COG0583	DNA-binding transcription factor activity
I5M57_11990	COG2840	Smr protein MutS2
I5M57_11995	COG1414	Transcriptional regulator
I5M57_12005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5M57_12010	COG0183	Belongs to the thiolase family
I5M57_12020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5M57_12025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M57_12035	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M57_12035	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M57_12055	COG4565	transcriptional regulatory protein
I5M57_12060	COG3290	protein histidine kinase activity
I5M57_12085	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5M57_12095	COG0679	Auxin Efflux Carrier
I5M57_12125	COG0628	permease
I5M57_12145	COG3591	Belongs to the peptidase S1B family
I5M57_12155	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I5M57_12160	COG2814	Major facilitator Superfamily
I5M57_12165	COG0583	DNA-binding transcription factor activity
I5M57_12170	COG1940	carbohydrate kinase activity
I5M57_12175	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I5M57_12190	COG3302	dmso reductase anchor subunit
I5M57_12195	COG0437	4 iron, 4 sulfur cluster binding
I5M57_12225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M57_12240	COG2271	Major facilitator Superfamily
I5M57_12245	COG0246	Mannitol dehydrogenase
I5M57_12250	COG0589	response to stress
I5M57_12255	COG1802	Transcriptional regulator
I5M57_12260	COG4221	oxidoreductase activity
I5M57_12275	COG2207	Transcriptional regulator
I5M57_12280	COG2135	peptidase activity
I5M57_12295	COG2197	response regulator
I5M57_12310	COG0071	Belongs to the small heat shock protein (HSP20) family
I5M57_12315	COG1546	Belongs to the CinA family
I5M57_12320	COG2200	EAL domain
I5M57_12340	COG2207	Transcriptional regulator
I5M57_12340	COG3708	Transcriptional regulator
I5M57_12345	COG2610	gluconate transmembrane transporter activity
I5M57_12350	COG3622	Belongs to the hyi family
I5M57_12355	COG0235	Class ii aldolase
I5M57_12360	COG3395	kinase activity
I5M57_12365	COG2084	Dehydrogenase
I5M57_12370	COG1349	DNA-binding transcription factor activity
I5M57_12385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5M57_12390	COG2223	nitrite transmembrane transporter activity
I5M57_12425	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5M57_12430	COG0683	leucine binding
I5M57_12445	COG1129	ABC transporter
I5M57_12450	COG0410	ABC transporter
I5M57_12460	COG2814	Major facilitator Superfamily
I5M57_12465	COG0697	spore germination
I5M57_12475	COG4977	sequence-specific DNA binding
I5M57_12505	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_12510	COG2731	YhcH YjgK YiaL family protein
I5M57_12525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5M57_12535	COG3395	kinase activity
I5M57_12540	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I5M57_12545	COG1349	DNA-binding transcription factor activity
I5M57_12550	COG0039	L-malate dehydrogenase activity
I5M57_12560	COG0583	DNA-binding transcription factor activity
I5M57_12565	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_12580	COG2199	diguanylate cyclase activity
I5M57_12650	COG0477	Major facilitator Superfamily
I5M57_12660	COG2070	2-Nitropropane dioxygenase
I5M57_12665	COG2011	ABC-type metal ion transport system permease component
I5M57_12685	COG4628	conserved protein (DUF2132)
I5M57_12700	COG2207	Transcriptional regulator
I5M57_12730	COG2233	PERMEase
I5M57_12735	COG3195	allantoin biosynthetic process
I5M57_12735	COG3648	Uricase
I5M57_12740	COG2351	hydroxyisourate hydrolase activity
I5M57_12745	COG1396	sequence-specific DNA binding
I5M57_12750	COG3550	peptidyl-serine autophosphorylation
I5M57_12755	COG1649	PFAM Uncharacterised BCR, COG1649
I5M57_12765	COG3188	usher protein
I5M57_12800	COG5001	Diguanylate cyclase
I5M57_12800	COG3300	MHYT domain
I5M57_12805	COG2819	hydrolase of the alpha beta superfamily
I5M57_12820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_12820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_12825	COG2814	Major facilitator Superfamily
I5M57_12835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M57_12835	COG1263	PTS System
I5M57_12840	COG2186	Transcriptional regulator
I5M57_12860	COG3835	regulator
I5M57_12865	COG1929	Belongs to the glycerate kinase type-1 family
I5M57_12910	COG0738	Major facilitator superfamily
I5M57_12915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M57_12920	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5M57_12925	COG1349	DNA-binding transcription factor activity
I5M57_12940	COG1349	DNA-binding transcription factor activity
I5M57_12945	COG4977	sequence-specific DNA binding
I5M57_12965	COG4977	sequence-specific DNA binding
I5M57_12985	COG0667	Aldo Keto reductase
I5M57_12995	COG0667	Aldo Keto reductase
I5M57_13000	COG0667	Aldo Keto reductase
I5M57_13010	COG0456	acetyltransferase
I5M57_13010	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I5M57_13035	COG0426	domain, Protein
I5M57_13035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5M57_13060	COG1652	LysM domain
I5M57_13090	COG1609	Transcriptional regulator
I5M57_13100	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M57_13115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5M57_13125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5M57_13130	COG0583	DNA-binding transcription factor activity
I5M57_13135	COG0583	DNA-binding transcription factor activity
I5M57_13150	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I5M57_13150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M57_13150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M57_13155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M57_13165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5M57_13170	COG3037	sugar-specific permease SgaT UlaA
I5M57_13180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_13185	COG1609	Transcriptional regulator
I5M57_13195	COG2223	nitrite transmembrane transporter activity
I5M57_13225	COG0477	Major facilitator Superfamily
I5M57_13230	COG4529	Protein conserved in bacteria
I5M57_13235	COG1902	pentaerythritol trinitrate reductase activity
I5M57_13245	COG0583	DNA-binding transcription factor activity
I5M57_13250	COG2070	2-Nitropropane dioxygenase
I5M57_13260	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5M57_13270	COG0765	amino acid transport
I5M57_13340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M57_13370	COG1335	isochorismatase
I5M57_13375	COG0406	alpha-ribazole phosphatase activity
I5M57_13410	COG1953	Uracil, thiamine, allantoin
I5M57_13415	COG0402	S-adenosylhomocysteine deaminase activity
I5M57_13420	COG3706	GGDEF domain
I5M57_13425	COG1609	Transcriptional regulator
I5M57_13435	COG0673	inositol 2-dehydrogenase activity
I5M57_13450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5M57_13455	COG1116	anion transmembrane transporter activity
I5M57_13460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M57_13465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M57_13470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M57_13475	COG0076	glutamate decarboxylase activity
I5M57_13490	COG2205	protein histidine kinase activity
I5M57_13500	COG0596	Alpha beta hydrolase
I5M57_13540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I5M57_13540	COG0519	Catalyzes the synthesis of GMP from XMP
I5M57_13560	COG0583	DNA-binding transcription factor activity
I5M57_13570	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5M57_13575	COG1285	pathogenesis
I5M57_13580	COG2814	Major facilitator Superfamily
I5M57_13585	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M57_13590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M57_13615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M57_13620	COG0583	DNA-binding transcription factor activity
I5M57_13625	COG0243	molybdopterin cofactor binding
I5M57_13630	COG3781	membrane
I5M57_13655	COG1764	response to oxidative stress
I5M57_13665	COG3111	PFAM Bacterial OB fold (BOF) protein
I5M57_13675	COG2323	membrane
I5M57_13685	COG0366	Alpha amylase catalytic
I5M57_13695	COG3685	Protein conserved in bacteria
I5M57_13705	COG3729	General stress protein
I5M57_13710	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_13755	COG0488	(ABC) transporter
I5M57_13770	COG1064	alcohol dehydrogenase
I5M57_13775	COG0747	negative chemotaxis
I5M57_13785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M57_13795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M57_13805	COG2814	Major facilitator Superfamily
I5M57_13815	COG2326	polyphosphate kinase activity
I5M57_13830	COG2864	formate dehydrogenase
I5M57_13835	COG0437	4 iron, 4 sulfur cluster binding
I5M57_13860	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I5M57_13870	COG3485	protocatechuate 3,4-dioxygenase
I5M57_13875	COG4829	muconolactone delta-isomerase
I5M57_13880	COG4948	Mandelate Racemase Muconate Lactonizing
I5M57_13885	COG1414	Transcriptional regulator
I5M57_13905	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5M57_13910	COG1140	nitrate reductase beta subunit
I5M57_13915	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I5M57_13920	COG2181	nitrate reductase activity
I5M57_13925	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I5M57_13930	COG1178	ABC-type Fe3 transport system permease component
I5M57_13935	COG1840	ABC-type Fe3 transport system, periplasmic component
I5M57_13940	COG3842	ATPase activity
I5M57_13945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5M57_13980	COG0625	glutathione transferase activity
I5M57_13990	COG1126	abc transporter atp-binding protein
I5M57_13995	COG0765	amino acid transport
I5M57_14005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M57_14010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M57_14015	COG1473	amidohydrolase
I5M57_14020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M57_14025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5M57_14050	COG4772	TonB-dependent receptor
I5M57_14055	COG1228	amidohydrolase
I5M57_14060	COG3691	Protein conserved in bacteria
I5M57_14075	COG2130	NADP-dependent
I5M57_14085	COG1247	-acetyltransferase
I5M57_14090	COG3238	Protein conserved in bacteria
I5M57_14100	COG0747	negative chemotaxis
I5M57_14105	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_14140	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_14145	COG1177	transmembrane transport
I5M57_14150	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5M57_14155	COG3842	ATPase activity
I5M57_14160	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5M57_14165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M57_14170	COG1271	oxidase subunit
I5M57_14175	COG1294	oxidase, subunit
I5M57_14195	COG0826	peptidase U32
I5M57_14205	COG1396	sequence-specific DNA binding
I5M57_14210	COG3135	benzoate transporter
I5M57_14215	COG2207	Transcriptional regulator
I5M57_14215	COG3708	Transcriptional regulator
I5M57_14230	COG0500	methyltransferase
I5M57_14235	COG1275	C4-dicarboxylate transporter malic acid transport protein
I5M57_14240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5M57_14245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M57_14260	COG2272	Belongs to the type-B carboxylesterase lipase family
I5M57_14265	COG5383	Protein conserved in bacteria
I5M57_14270	COG3485	protocatechuate 3,4-dioxygenase
I5M57_14275	COG3485	protocatechuate 3,4-dioxygenase
I5M57_14280	COG0583	DNA-binding transcription factor activity
I5M57_14300	COG3038	cytochrome b561
I5M57_14320	COG2814	Major facilitator Superfamily
I5M57_14330	COG0673	inositol 2-dehydrogenase activity
I5M57_14340	COG2723	6-phospho-beta-galactosidase activity
I5M57_14375	COG4659	FMN binding
I5M57_14385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5M57_14395	COG0625	glutathione transferase activity
I5M57_14400	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I5M57_14415	COG3895	Periplasmic Protein
I5M57_14430	COG3706	GGDEF domain
I5M57_14445	COG1566	PFAM secretion protein HlyD family protein
I5M57_14450	COG1289	transmembrane transporter activity
I5M57_14455	COG2032	superoxide dismutase activity
I5M57_14460	COG4989	oxidoreductase activity
I5M57_14465	COG3313	Fe-S protein
I5M57_14470	COG1309	transcriptional regulator
I5M57_14475	COG1902	pentaerythritol trinitrate reductase activity
I5M57_14480	COG0346	lactoylglutathione lyase activity
I5M57_14490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I5M57_14495	COG0791	NLP P60 protein
I5M57_14510	COG2814	Major facilitator Superfamily
I5M57_14525	COG0583	DNA-binding transcription factor activity
I5M57_14530	COG2814	Major facilitator Superfamily
I5M57_14535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5M57_14540	COG0307	riboflavin synthase, alpha
I5M57_14590	COG1234	tRNA 3'-trailer cleavage
I5M57_14625	COG1349	DNA-binding transcription factor activity
I5M57_14630	COG0346	lactoylglutathione lyase activity
I5M57_14655	COG0444	Belongs to the ABC transporter superfamily
I5M57_14660	COG4608	Belongs to the ABC transporter superfamily
I5M57_14690	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_14690	COG0604	alcohol dehydrogenase
I5M57_14690	COG3321	synthase
I5M57_14735	COG0402	S-adenosylhomocysteine deaminase activity
I5M57_14760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M57_14765	COG0277	FAD linked oxidase domain protein
I5M57_14790	COG0583	DNA-binding transcription factor activity
I5M57_14800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5M57_14810	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5M57_14815	COG2610	gluconate transmembrane transporter activity
I5M57_14820	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_14855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M57_14885	COG3088	subunit of a heme lyase
I5M57_14885	COG4235	cytochrome complex assembly
I5M57_14890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5M57_14895	COG1138	Cytochrome C-type biogenesis protein
I5M57_14910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5M57_14915	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5M57_14920	COG4133	protoheme IX ABC transporter activity
I5M57_14950	COG1175	transmembrane transport
I5M57_14960	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I5M57_14965	COG3383	formate dehydrogenase (NAD+) activity
I5M57_15005	COG1126	abc transporter atp-binding protein
I5M57_15010	COG0765	amino acid transport
I5M57_15030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M57_15035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M57_15040	COG1120	ATPase activity
I5M57_15045	COG4774	siderophore transport
I5M57_15050	COG1116	anion transmembrane transporter activity
I5M57_15055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M57_15075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M57_15080	COG0583	DNA-binding transcription factor activity
I5M57_15100	COG2814	Major facilitator Superfamily
I5M57_15135	COG1414	Transcriptional regulator
I5M57_15140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5M57_15145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M57_15150	COG1120	ATPase activity
I5M57_15160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5M57_15165	COG2271	Major facilitator Superfamily
I5M57_15170	COG1082	Xylose isomerase domain protein TIM barrel
I5M57_15170	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I5M57_15175	COG1309	transcriptional regulator
I5M57_15205	COG1376	ErfK ybiS ycfS ynhG family protein
I5M57_15220	COG0719	Fe-S assembly protein
I5M57_15225	COG0396	ATPase activity
I5M57_15230	COG0719	Fe-S assembly protein
I5M57_15235	COG0316	Belongs to the HesB IscA family
I5M57_15255	COG1309	transcriptional regulator
I5M57_15260	COG1304	FMN binding
I5M57_15285	COG0583	DNA-binding transcription factor activity
I5M57_15295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M57_15300	COG1120	ATPase activity
I5M57_15325	COG2261	transglycosylase associated protein
I5M57_15330	COG2050	protein possibly involved in aromatic compounds catabolism
I5M57_15335	COG0247	lactate metabolic process
I5M57_15335	COG0277	FAD linked oxidase domain protein
I5M57_15340	COG0628	permease
I5M57_15350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5M57_15350	COG0574	Belongs to the PEP-utilizing enzyme family
I5M57_15365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M57_15370	COG4256	Hemin uptake protein
I5M57_15380	COG0791	NLP P60 protein
I5M57_15390	COG0386	Belongs to the glutathione peroxidase family
I5M57_15410	COG0583	DNA-binding transcription factor activity
I5M57_15430	COG0072	phenylalanine-tRNA ligase activity
I5M57_15430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5M57_15470	COG3137	Salt-induced outer membrane protein
I5M57_15475	COG1105	Belongs to the carbohydrate kinase PfkB family
I5M57_15485	COG3001	Fructosamine kinase
I5M57_15495	COG2350	Protein conserved in bacteria
I5M57_15505	COG2353	YceI-like domain
I5M57_15525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5M57_15535	COG0444	Belongs to the ABC transporter superfamily
I5M57_15540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M57_15545	COG0601	transmembrane transport
I5M57_15550	COG4166	transmembrane transport
I5M57_15555	COG2095	MarC family integral membrane protein
I5M57_15565	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_15565	COG1454	alcohol dehydrogenase
I5M57_15570	COG1435	thymidine kinase activity
I5M57_15580	COG2916	Histone family protein nucleoid-structuring protein H-NS
I5M57_15585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I5M57_15590	COG0745	RESPONSE REGULATOR receiver
I5M57_15595	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5M57_15605	COG0788	formyltetrahydrofolate deformylase activity
I5M57_15640	COG1522	sequence-specific DNA binding
I5M57_15650	COG2181	nitrate reductase activity
I5M57_15655	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I5M57_15660	COG1140	nitrate reductase beta subunit
I5M57_15665	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5M57_15675	COG2223	nitrite transmembrane transporter activity
I5M57_15680	COG3850	Histidine kinase
I5M57_15685	COG2197	response regulator
I5M57_15690	COG4932	domain protein
I5M57_15695	COG0243	molybdopterin cofactor binding
I5M57_15700	COG2146	nitrite reductase [NAD(P)H] activity
I5M57_15700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5M57_15705	COG1116	anion transmembrane transporter activity
I5M57_15715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M57_15720	COG3707	response regulator
I5M57_15725	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I5M57_15735	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I5M57_15740	COG4572	Cation transport regulator
I5M57_15745	COG0387	Pfam Sodium calcium exchanger
I5M57_15765	COG2890	protein-(glutamine-N5) methyltransferase activity
I5M57_15795	COG0659	secondary active sulfate transmembrane transporter activity
I5M57_15815	COG0012	GTP binding
I5M57_15965	COG2885	chlorophyll binding
I5M57_15985	COG3122	Protein conserved in bacteria
I5M57_16000	COG0583	DNA-binding transcription factor activity
I5M57_16030	COG0583	DNA-binding transcription factor activity
I5M57_16065	COG1882	Formate acetyltransferase
I5M57_16080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5M57_16085	COG0583	DNA-binding transcription factor activity
I5M57_16125	COG2308	Evidence 4 Homologs of previously reported genes of
I5M57_16140	COG4774	siderophore transport
I5M57_16150	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5M57_16175	COG2719	SpoVR family
I5M57_16205	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5M57_16220	COG2894	cell division
I5M57_16230	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I5M57_16240	COG3065	identical protein binding
I5M57_16250	COG1199	ATP-dependent helicase activity
I5M57_16255	COG0251	oxidation-reduction process
I5M57_16275	COG1760	l-serine dehydratase
I5M57_16280	COG2200	EAL domain
I5M57_16285	COG1253	flavin adenine dinucleotide binding
I5M57_16290	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M57_16290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_16295	COG3715	PTS system
I5M57_16300	COG3716	PTS system mannose fructose sorbose family IID component
I5M57_16315	COG2226	methyltransferase
I5M57_16320	COG0768	penicillin binding
I5M57_16350	COG1414	Transcriptional regulator
I5M57_16355	COG2814	Major facilitator Superfamily
I5M57_16375	COG1956	GAF domain-containing protein
I5M57_16380	COG2995	paraquat-inducible protein a
I5M57_16385	COG3008	intermembrane lipid transfer
I5M57_16410	COG2990	Protein conserved in bacteria
I5M57_16425	COG1276	copper resistance
I5M57_16430	COG2372	response to copper ion
I5M57_16440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5M57_16445	COG1770	oligopeptidase
I5M57_16450	COG2979	Protein of unknown function (DUF533)
I5M57_16455	COG3141	response to X-ray
I5M57_16465	COG0800	Aldolase
I5M57_16470	COG0129	dihydroxy-acid dehydratase activity
I5M57_16475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5M57_16485	COG1737	Transcriptional regulator
I5M57_16495	COG1560	Kdo2-lipid A biosynthetic process
I5M57_16500	COG0739	heme binding
I5M57_16505	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I5M57_16515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M57_16540	COG0494	nUDIX hydrolase
I5M57_16550	COG1335	isochorismatase
I5M57_16555	COG1801	Protein of unknown function DUF72
I5M57_16560	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I5M57_16580	COG3102	Protein conserved in bacteria
I5M57_16590	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I5M57_16615	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M57_16625	COG1879	ABC-type sugar transport system periplasmic component
I5M57_16635	COG1528	Iron-storage protein
I5M57_16645	COG2211	Major facilitator Superfamily
I5M57_16655	COG0477	Major facilitator Superfamily
I5M57_16675	COG1528	Iron-storage protein
I5M57_16685	COG0814	amino acid
I5M57_16690	COG3012	SEC-C Motif Domain Protein
I5M57_16690	COG3318	Belongs to the UPF0149 family
I5M57_16725	COG2197	response regulator
I5M57_16735	COG2197	response regulator
I5M57_16740	COG1126	abc transporter atp-binding protein
I5M57_16745	COG0765	amino acid transport
I5M57_16755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M57_16760	COG0366	Alpha amylase catalytic
I5M57_16790	COG2354	Protein conserved in bacteria
I5M57_16795	COG0697	spore germination
I5M57_16800	COG3727	T/G mismatch-specific endonuclease activity
I5M57_16805	COG0270	DNA (cytosine-5-)-methyltransferase activity
I5M57_16810	COG1418	mRNA catabolic process
I5M57_16820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5M57_16865	COG0025	NhaP-type Na H and K H
I5M57_16875	COG0604	alcohol dehydrogenase
I5M57_16905	COG0534	Mate efflux family protein
I5M57_16915	COG0582	viral genome integration into host DNA
I5M57_16920	COG1169	isochorismate synthase
I5M57_16925	COG2814	Major facilitator Superfamily
I5M57_16930	COG1132	(ABC) transporter
I5M57_16945	COG3433	isochorismatase activity
I5M57_16945	COG2226	methyltransferase
I5M57_16945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5M57_16965	COG1021	2,3-dihydroxybenzoate-AMP ligase
I5M57_16970	COG4771	TonB-dependent receptor
I5M57_17040	COG3504	Conjugal transfer protein
I5M57_17085	COG2003	Belongs to the UPF0758 family
I5M57_17135	COG3706	GGDEF domain
I5M57_17160	COG3615	Tellurite resistance protein tehB
I5M57_17170	COG5001	Diguanylate cyclase
I5M57_17170	COG3300	MHYT domain
I5M57_17180	COG3039	Transposase
I5M57_17185	COG0477	Major facilitator Superfamily
I5M57_17190	COG0095	Lipoate-protein ligase
I5M57_17195	COG0583	DNA-binding transcription factor activity
I5M57_17200	COG1942	4-Oxalocrotonate Tautomerase
I5M57_17210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I5M57_17230	COG1289	transmembrane transporter activity
I5M57_17240	COG3344	reverse transcriptase
I5M57_17250	COG2925	Exonuclease
I5M57_17255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5M57_17260	COG0640	Transcriptional regulator
I5M57_17265	COG0531	amino acid
I5M57_17275	COG0583	DNA-binding transcription factor activity
I5M57_17280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5M57_17310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I5M57_17375	COG1088	dTDP-glucose 4,6-dehydratase activity
I5M57_17410	COG1088	dTDP-glucose 4,6-dehydratase activity
I5M57_17420	COG2244	polysaccharide biosynthetic process
I5M57_17435	COG0463	Glycosyl transferase, family 2
I5M57_17500	COG1253	flavin adenine dinucleotide binding
I5M57_17505	COG2982	Protein involved in outer membrane biogenesis
I5M57_17520	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I5M57_17525	COG0443	Heat shock 70 kDa protein
I5M57_17530	COG5002	protein histidine kinase activity
I5M57_17550	COG1301	dicarboxylic acid transport
I5M57_17575	COG2205	protein histidine kinase activity
I5M57_17580	COG0745	RESPONSE REGULATOR receiver
I5M57_17585	COG0826	peptidase U32
I5M57_17595	COG4608	Belongs to the ABC transporter superfamily
I5M57_17600	COG0444	Belongs to the ABC transporter superfamily
I5M57_17605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M57_17610	COG0601	transmembrane transport
I5M57_17615	COG0747	negative chemotaxis
I5M57_17620	COG4948	Mandelate Racemase Muconate Lactonizing
I5M57_17625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M57_17635	COG1070	Carbohydrate kinase
I5M57_17670	COG1830	Aldolase
I5M57_17675	COG0351	phosphomethylpyrimidine kinase
I5M57_17690	COG0583	DNA-binding transcription factor activity
I5M57_17700	COG2252	PERMEase
I5M57_17705	COG0583	DNA-binding transcription factor activity
I5M57_17710	COG5455	response to cobalt ion
I5M57_17730	COG4807	Protein conserved in bacteria
I5M57_17740	COG3275	phosphorelay sensor kinase activity
I5M57_17750	COG1174	glycine betaine transport
I5M57_17755	COG1125	glycine betaine transport
I5M57_17760	COG1174	glycine betaine transport
I5M57_17765	COG1732	Glycine betaine
I5M57_17770	COG1472	Belongs to the glycosyl hydrolase 3 family
I5M57_17775	COG0277	FAD linked oxidase domain protein
I5M57_17785	COG1686	Belongs to the peptidase S11 family
I5M57_17795	COG0586	Pfam SNARE associated Golgi protein
I5M57_17800	COG1538	Outer membrane efflux protein
I5M57_17805	COG2723	6-phospho-beta-galactosidase activity
I5M57_17820	COG3659	wide pore channel activity
I5M57_17825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5M57_17835	COG1346	cytolysis
I5M57_17845	COG2949	membrane
I5M57_17855	COG1129	ABC transporter
I5M57_17870	COG2311	Membrane
I5M57_17885	COG4771	TonB-dependent receptor
I5M57_17895	COG0833	amino acid
I5M57_17900	COG0583	DNA-binding transcription factor activity
I5M57_17905	COG2855	membrane
I5M57_17915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M57_17915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M57_17915	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I5M57_17920	COG1105	Belongs to the carbohydrate kinase PfkB family
I5M57_17925	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_17925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_17950	COG1312	Catalyzes the dehydration of D-mannonate
I5M57_17955	COG0246	Mannitol dehydrogenase
I5M57_17960	COG0523	cobalamin synthesis protein
I5M57_17965	COG0671	phosphoesterase, PA-phosphatase related
I5M57_17970	COG0791	NLP P60 protein
I5M57_17975	COG2200	EAL domain
I5M57_17980	COG4166	transmembrane transport
I5M57_17985	COG4174	ABC transporter (Permease)
I5M57_17990	COG4239	(ABC) transporter, permease
I5M57_17995	COG4172	Belongs to the ABC transporter superfamily
I5M57_18005	COG2814	Major facilitator Superfamily
I5M57_18010	COG1187	pseudouridine synthase activity
I5M57_18015	COG1061	Type III restriction enzyme res subunit
I5M57_18035	COG0494	nUDIX hydrolase
I5M57_18040	COG1349	DNA-binding transcription factor activity
I5M57_18065	COG0628	permease
I5M57_18080	COG0659	secondary active sulfate transmembrane transporter activity
I5M57_18085	COG2239	Acts as a magnesium transporter
I5M57_18090	COG4615	Cyclic peptide transporter
I5M57_18095	COG3145	DNA-N1-methyladenine dioxygenase activity
I5M57_18100	COG2169	Transcriptional regulator
I5M57_18100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5M57_18115	COG0642	Histidine kinase
I5M57_18115	COG2198	Histidine kinase
I5M57_18125	COG2205	protein histidine kinase activity
I5M57_18125	COG0784	Response regulator, receiver
I5M57_18150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M57_18155	COG0584	glycerophosphoryl diester phosphodiesterase
I5M57_18160	COG2271	Major facilitator Superfamily
I5M57_18165	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5M57_18175	COG0247	lactate metabolic process
I5M57_18185	COG2271	Major facilitator Superfamily
I5M57_18195	COG3344	reverse transcriptase
I5M57_18205	COG1414	Transcriptional regulator
I5M57_18220	COG5464	transposase or invertase
I5M57_18230	COG0318	PFAM AMP-dependent synthetase and ligase
I5M57_18255	COG1169	isochorismate synthase
I5M57_18260	COG2153	protein acetylation
I5M57_18275	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5M57_18280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5M57_18290	COG0839	Belongs to the complex I subunit 6 family
I5M57_18335	COG0583	DNA-binding transcription factor activity
I5M57_18340	COG0436	Aminotransferase
I5M57_18350	COG0490	domain, Protein
I5M57_18350	COG0471	metal ion transport
I5M57_18355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M57_18375	COG0280	phosphate acetyltransferase
I5M57_18375	COG0857	belongs to the CobB CobQ family
I5M57_18380	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I5M57_18385	COG0622	Phosphoesterase
I5M57_18390	COG0625	glutathione transferase activity
I5M57_18395	COG0625	glutathione transferase activity
I5M57_18400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5M57_18405	COG1090	epimerase
I5M57_18420	COG4598	ABC transporter
I5M57_18425	COG4160	amino acid transport
I5M57_18450	COG0163	prenyltransferase activity
I5M57_18455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I5M57_18460	COG1286	toxin biosynthetic process
I5M57_18465	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I5M57_18470	COG0285	dihydrofolate synthase activity
I5M57_18480	COG0586	Pfam SNARE associated Golgi protein
I5M57_18490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5M57_18510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M57_18525	COG3101	peptidyl-lysine hydroxylation
I5M57_18530	COG0730	response to heat
I5M57_18555	COG2062	phosphohistidine phosphatase, SixA
I5M57_18570	COG3691	Protein conserved in bacteria
I5M57_18580	COG2853	Lipoprotein
I5M57_18585	COG2116	formate transmembrane transporter activity
I5M57_18605	COG0583	DNA-binding transcription factor activity
I5M57_18610	COG0590	tRNA wobble adenosine to inosine editing
I5M57_18615	COG2807	transmembrane transport
I5M57_18625	COG0436	Aminotransferase
I5M57_18640	COG3275	phosphorelay sensor kinase activity
I5M57_18645	COG3279	Response regulator of the LytR AlgR family
I5M57_18660	COG3961	Belongs to the TPP enzyme family
I5M57_18665	COG0667	Aldo Keto reductase
I5M57_18680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M57_18685	COG2200	EAL domain
I5M57_18685	COG2199	diguanylate cyclase activity
I5M57_18700	COG3415	Transposase
I5M57_18705	COG3415	Transposase
I5M57_18735	COG0583	DNA-binding transcription factor activity
I5M57_18740	COG0385	Bile acid
I5M57_18745	COG3530	Putative quorum-sensing-regulated virulence factor
I5M57_18765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5M57_18800	COG4319	ketosteroid isomerase
I5M57_18810	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I5M57_18815	COG4208	sulfate ABC transporter
I5M57_18820	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I5M57_18825	COG4150	thiosulfate binding
I5M57_18835	COG2837	iron assimilation
I5M57_18855	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5M57_18945	COG4810	utilization protein
I5M57_18955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5M57_18960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5M57_18965	COG5342	invasion associated locus B
I5M57_18975	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M57_18975	COG0493	'glutamate synthase
I5M57_18980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M57_18990	COG1393	Belongs to the ArsC family
I5M57_19005	COG0400	carboxylic ester hydrolase activity
I5M57_19010	COG1444	tRNA N-acetyltransferase activity
I5M57_19015	COG2321	neutral zinc metallopeptidase
I5M57_19025	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I5M57_19035	COG2716	regulation of RNA biosynthetic process
I5M57_19040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5M57_19045	COG0628	permease
I5M57_19055	COG4783	chaperone-mediated protein folding
I5M57_19060	COG1393	Belongs to the ArsC family
I5M57_19075	COG2233	PERMEase
I5M57_19085	COG2723	6-phospho-beta-galactosidase activity
I5M57_19100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5M57_19115	COG2200	EAL domain
I5M57_19135	COG0641	radical SAM
I5M57_19140	COG3119	arylsulfatase activity
I5M57_19150	COG3179	chitinase
I5M57_19170	COG3039	Transposase
I5M57_19195	COG3039	Transposase
I5M57_19225	COG3344	reverse transcriptase
I5M57_19320	COG3728	DNA packaging
I5M57_19320	COG5484	DNA packaging
I5M57_19330	COG3344	reverse transcriptase
I5M57_19415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5M57_19465	COG0517	IMP dehydrogenase activity
I5M57_19465	COG0516	GMP reductase activity
I5M57_19475	COG1645	bacterial-type flagellum-dependent swarming motility
I5M57_19495	COG2976	Protein conserved in bacteria
I5M57_19525	COG4953	penicillin-binding protein 1C
I5M57_19530	COG2373	Large extracellular alpha-helical protein
I5M57_19535	COG2897	thiosulfate sulfurtransferase activity
I5M57_19555	COG2975	iron-sulfur cluster assembly
I5M57_19560	COG0633	Ferredoxin
I5M57_19580	COG0822	iron-sulfur transferase activity
I5M57_19610	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I5M57_19615	COG3683	transport system, periplasmic component
I5M57_19620	COG3711	transcriptional antiterminator
I5M57_19625	COG2814	Major facilitator Superfamily
I5M57_19630	COG2017	converts alpha-aldose to the beta-anomer
I5M57_19635	COG2814	Major facilitator Superfamily
I5M57_19635	COG0477	Major facilitator Superfamily
I5M57_19640	COG0457	Tetratricopeptide repeat
I5M57_19645	COG1940	carbohydrate kinase activity
I5M57_19650	COG2259	Doxx family
I5M57_19660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M57_19660	COG1017	nitric oxide dioxygenase activity
I5M57_19665	COG0347	Belongs to the P(II) protein family
I5M57_19670	COG2204	response regulator
I5M57_19675	COG3170	Tfp pilus assembly protein FimV
I5M57_19680	COG2205	protein histidine kinase activity
I5M57_19685	COG0047	phosphoribosylformylglycinamidine synthase activity
I5M57_19685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5M57_19700	COG0560	Phosphoserine phosphatase
I5M57_19705	COG1737	Transcriptional regulator
I5M57_19710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M57_19720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I5M57_19740	COG0681	Belongs to the peptidase S26 family
I5M57_19750	COG3086	response to oxidative stress
I5M57_19755	COG3026	antisigma factor binding
I5M57_19760	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I5M57_19775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I5M57_19785	COG0513	Belongs to the DEAD box helicase family
I5M57_19800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M57_19805	COG3118	belongs to the thioredoxin family
I5M57_19810	COG3148	PFAM DTW domain containing protein
I5M57_19820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M57_19825	COG5544	Lipoprotein
I5M57_19830	COG0477	Major facilitator Superfamily
I5M57_19855	COG0542	response to heat
I5M57_19870	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M57_19875	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5M57_19885	COG1605	Chorismate mutase
I5M57_19885	COG0077	Prephenate dehydratase
I5M57_19895	COG0287	Prephenate dehydrogenase
I5M57_19895	COG1605	Chorismate mutase
I5M57_19900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M57_19910	COG2199	diguanylate cyclase activity
I5M57_19915	COG2885	chlorophyll binding
I5M57_19950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5M57_19955	COG4137	Cytochrome C assembly protein
I5M57_19960	COG4536	flavin adenine dinucleotide binding
I5M57_19975	COG0497	DNA recombination
I5M57_19990	COG2867	negative regulation of translational initiation
I5M57_20155	COG4695	Portal protein
I5M57_20190	COG3344	reverse transcriptase
I5M57_20205	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5M57_20240	COG4974	Belongs to the 'phage' integrase family
I5M57_20255	COG2197	response regulator
I5M57_20260	COG3539	Fimbrial protein
I5M57_20270	COG3188	usher protein
I5M57_20290	COG3121	Chaperone
I5M57_20295	COG3539	Fimbrial protein
I5M57_20305	COG3284	Transcriptional regulator
I5M57_20310	COG0583	DNA-binding transcription factor activity
I5M57_20320	COG0640	Transcriptional regulator
I5M57_20325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5M57_20340	COG2916	Histone family protein nucleoid-structuring protein H-NS
I5M57_20355	COG4575	ribosome binding
I5M57_20360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M57_20365	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M57_20370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5M57_20380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5M57_20395	COG4176	ABC-type proline glycine betaine transport system permease component
I5M57_20405	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I5M57_20415	COG1846	Transcriptional regulator
I5M57_20420	COG1566	PFAM secretion protein HlyD family protein
I5M57_20425	COG2814	Major facilitator Superfamily
I5M57_20430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5M57_20450	COG1238	metal cluster binding
I5M57_20455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M57_20460	COG2823	Periplasmic or secreted lipoprotein
I5M57_20490	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5M57_20510	COG1546	Belongs to the CinA family
I5M57_20520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M57_20525	COG1121	(ABC) transporter
I5M57_20530	COG2951	lytic endotransglycosylase activity
I5M57_20535	COG3730	PTS system glucitol sorbitol-specific
I5M57_20540	COG3732	PTS system glucitol sorbitol-specific
I5M57_20550	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_20555	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_20560	COG1349	DNA-binding transcription factor activity
I5M57_20585	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I5M57_20590	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I5M57_20595	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M57_20600	COG1609	Transcriptional regulator
I5M57_20605	COG1263	PTS System
I5M57_20605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M57_20610	COG2723	6-phospho-beta-galactosidase activity
I5M57_20620	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I5M57_20630	COG3260	NADH ubiquinone oxidoreductase 20
I5M57_20635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5M57_20640	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I5M57_20640	COG3261	NADH dehydrogenase
I5M57_20645	COG0650	Formate hydrogenlyase subunit 4
I5M57_20650	COG0651	ATP synthesis coupled electron transport
I5M57_20655	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M57_20670	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I5M57_20675	COG0298	carbon dioxide binding
I5M57_20680	COG0409	Hydrogenase expression formation protein
I5M57_20685	COG0309	Hydrogenase expression formation protein (HypE)
I5M57_20695	COG2723	6-phospho-beta-galactosidase activity
I5M57_20705	COG4580	involved in the transport of maltose and maltodextrins
I5M57_20710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M57_20715	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M57_20720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M57_20725	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M57_20730	COG1940	carbohydrate kinase activity
I5M57_20735	COG1609	Transcriptional regulator
I5M57_20740	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5M57_20745	COG1121	(ABC) transporter
I5M57_20750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M57_20755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M57_20770	COG0679	Auxin Efflux Carrier
I5M57_20790	COG3720	iron ion transport
I5M57_20795	COG4558	Periplasmic binding protein
I5M57_20800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M57_20840	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I5M57_20845	COG0163	prenyltransferase activity
I5M57_20870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5M57_20875	COG4942	peptidase
I5M57_20875	COG1388	LysM domain
I5M57_20935	COG2234	aminopeptidase activity
I5M57_20955	COG0720	synthase
I5M57_20960	COG0602	queuosine metabolic process
I5M57_20980	COG3956	TIGRFAM MazG family protein
I5M57_20985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5M57_20995	COG2205	protein histidine kinase activity
I5M57_20995	COG3850	Histidine kinase
I5M57_20995	COG4999	Histidine kinase
I5M57_20995	COG3437	response regulator, receiver
I5M57_21000	COG1929	Belongs to the glycerate kinase type-1 family
I5M57_21005	COG4948	Mandelate Racemase Muconate Lactonizing
I5M57_21010	COG4948	Mandelate Racemase Muconate Lactonizing
I5M57_21015	COG2271	Major facilitator Superfamily
I5M57_21020	COG0716	FMN binding
I5M57_21025	COG0564	pseudouridine synthase activity
I5M57_21030	COG3098	single-species biofilm formation
I5M57_21045	COG1611	Belongs to the LOG family
I5M57_21050	COG0814	amino acid
I5M57_21055	COG1760	l-serine dehydratase
I5M57_21060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M57_21070	COG0477	Major facilitator Superfamily
I5M57_21075	COG1464	Belongs to the NlpA lipoprotein family
I5M57_21080	COG2011	ABC-type metal ion transport system permease component
I5M57_21085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5M57_21100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M57_21120	COG1454	alcohol dehydrogenase
I5M57_21125	COG0235	Class ii aldolase
I5M57_21130	COG0738	Major facilitator superfamily
I5M57_21150	COG1349	DNA-binding transcription factor activity
I5M57_21160	COG2363	Small membrane protein
I5M57_21165	COG0583	DNA-binding transcription factor activity
I5M57_21175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5M57_21180	COG2166	iron-sulfur cluster assembly
I5M57_21185	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5M57_21190	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I5M57_21355	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I5M57_21385	COG1012	belongs to the aldehyde dehydrogenase family
I5M57_21385	COG1454	alcohol dehydrogenase
I5M57_21390	COG4656	Part of a membrane complex involved in electron transport
I5M57_21420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5M57_21425	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5M57_21430	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I5M57_21430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5M57_21440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5M57_21445	COG1074	ATP-dependent DNA helicase activity
I5M57_21450	COG1025	Belongs to the peptidase M16 family
I5M57_21455	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I5M57_21460	COG4967	type IV pilus modification protein PilV
I5M57_21470	COG4795	General secretion pathway protein
I5M57_21475	COG2165	general secretion pathway protein
I5M57_21510	COG0861	Integral membrane protein TerC family
I5M57_21520	COG0667	Aldo Keto reductase
I5M57_21540	COG1609	Transcriptional regulator
I5M57_21550	COG2186	Transcriptional regulator
I5M57_21555	COG2723	6-phospho-beta-galactosidase activity
I5M57_21560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M57_21565	COG1609	Transcriptional regulator
I5M57_21575	COG0583	DNA-binding transcription factor activity
I5M57_21580	COG1794	racemase activity, acting on amino acids and derivatives
I5M57_21585	COG1917	Cupin 2, conserved barrel domain protein
I5M57_21590	COG1175	transmembrane transport
I5M57_21595	COG0395	ABC-type sugar transport system, permease component
I5M57_21600	COG3842	ATPase activity
I5M57_21635	COG2814	Major facilitator Superfamily
I5M57_21640	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_21645	COG0823	Involved in the tonB-independent uptake of proteins
I5M57_21655	COG0183	Belongs to the thiolase family
I5M57_21670	COG0814	amino acid
I5M57_21675	COG0667	Aldo Keto reductase
I5M57_21720	COG3039	Transposase
I5M57_21730	COG0697	spore germination
I5M57_21735	COG1846	Transcriptional regulator
I5M57_21740	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I5M57_21745	COG0582	viral genome integration into host DNA
I5M57_21750	COG4974	Belongs to the 'phage' integrase family
I5M57_21760	COG3539	Fimbrial protein
I5M57_21765	COG3121	Chaperone
I5M57_21770	COG3188	usher protein
I5M57_21775	COG3539	Fimbrial protein
I5M57_21780	COG3539	Fimbrial protein
I5M57_21785	COG3539	Fimbrial protein
I5M57_21795	COG2388	GCN5-related N-acetyl-transferase
I5M57_21800	COG3592	Divergent 4Fe-4S mono-cluster
I5M57_21815	COG1289	transmembrane transporter activity
I5M57_21820	COG1538	Outer membrane efflux protein
I5M57_21835	COG1393	Belongs to the ArsC family
I5M57_21840	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I5M57_21875	COG0667	Aldo Keto reductase
I5M57_21890	COG2814	Major facilitator Superfamily
I5M57_21900	COG4942	peptidase
I5M57_21920	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5M57_21930	COG4974	Belongs to the 'phage' integrase family
I5M57_21935	COG0716	FMN binding
I5M57_21945	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I5M57_21955	COG1272	protein, Hemolysin III
I5M57_21965	COG1737	Transcriptional regulator
I5M57_21970	COG2723	6-phospho-beta-galactosidase activity
I5M57_21990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5M57_21995	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_22015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M57_22020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M57_22025	COG0006	proline dipeptidase activity
I5M57_22045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5M57_22050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M57_22065	COG2968	Membrane
I5M57_22075	COG0668	transmembrane transport
I5M57_22080	COG0191	fructose-bisphosphate aldolase activity
I5M57_22095	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5M57_22125	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I5M57_22130	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_22160	COG1414	Transcriptional regulator
I5M57_22165	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_22180	COG2146	nitrite reductase [NAD(P)H] activity
I5M57_22215	COG2814	Major facilitator Superfamily
I5M57_22225	COG2356	endonuclease I
I5M57_22230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5M57_22235	COG0189	ligase activity
I5M57_22255	COG2805	Type II/IV secretion system protein
I5M57_22260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I5M57_22265	COG0762	integral membrane protein
I5M57_22280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5M57_22290	COG3171	Protein conserved in bacteria
I5M57_22300	COG1194	a g-specific adenine glycosylase
I5M57_22315	COG2211	Major facilitator Superfamily
I5M57_22320	COG1982	Orn Lys Arg decarboxylase major
I5M57_22325	COG1811	Na channel or pump
I5M57_22335	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I5M57_22400	COG3423	Transcriptional regulator
I5M57_22405	COG1278	Cold shock
I5M57_22415	COG3423	Transcriptional regulator
I5M57_22680	COG0626	cystathionine gamma-synthase activity
I5M57_22685	COG0583	DNA-binding transcription factor activity
I5M57_22705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M57_22710	COG0754	glutathionylspermidine amidase activity
I5M57_22725	COG0625	glutathione transferase activity
I5M57_22750	COG2211	Major facilitator Superfamily
I5M57_22755	COG0848	biopolymer transport protein
I5M57_22765	COG0626	cystathionine gamma-synthase activity
I5M57_22770	COG0586	Pfam SNARE associated Golgi protein
I5M57_22775	COG2207	Transcriptional regulator
I5M57_22780	COG1979	alcohol dehydrogenase
I5M57_22785	COG0656	L-ascorbic acid biosynthetic process
I5M57_22795	COG1032	radical SAM domain protein
I5M57_22800	COG2132	Multicopper oxidase
I5M57_22805	COG0204	Acyl-transferase
I5M57_22810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5M57_22815	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I5M57_22820	COG3111	PFAM Bacterial OB fold (BOF) protein
I5M57_22830	COG0642	Histidine kinase
I5M57_22835	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5M57_22840	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I5M57_22850	COG3150	esterase
I5M57_22855	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5M57_22860	COG3151	Protein conserved in bacteria
I5M57_22865	COG0494	nUDIX hydrolase
I5M57_22880	COG0754	glutathionylspermidine amidase activity
I5M57_22885	COG3384	dioxygenase
I5M57_22900	COG2960	long-chain fatty acid transporting porin activity
I5M57_22925	COG3025	triphosphatase activity
I5M57_22930	COG4991	sh3 domain protein
I5M57_22945	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5M57_23010	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I5M57_23015	COG0358	DNA primase activity
I5M57_23020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5M57_23045	COG2197	response regulator
I5M57_23050	COG2198	Histidine kinase
I5M57_23050	COG0784	Response regulator, receiver
I5M57_23050	COG2205	protein histidine kinase activity
I5M57_23050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M57_23060	COG3247	response to pH
I5M57_23130	COG2376	Dihydroxyacetone kinase
I5M57_23135	COG1461	Dihydroxyacetone kinase
I5M57_23150	COG2375	cellular response to nickel ion
I5M57_23155	COG1695	Transcriptional regulator
I5M57_23205	COG1902	pentaerythritol trinitrate reductase activity
I5M57_23205	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5M57_23225	COG1451	nucleotide metabolic process
I5M57_23230	COG0673	inositol 2-dehydrogenase activity
I5M57_23235	COG0861	Integral membrane protein TerC family
I5M57_23250	COG2721	sulfolactate sulfo-lyase activity
I5M57_23260	COG2271	Major facilitator Superfamily
I5M57_23265	COG2186	Transcriptional regulator
I5M57_23270	COG0586	Pfam SNARE associated Golgi protein
I5M57_23280	COG1422	Protein of unknown function (DUF1090)
I5M57_23285	COG4575	ribosome binding
I5M57_23290	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I5M57_23300	COG2259	Doxx family
I5M57_23305	COG0435	Glutathione S-transferase
I5M57_23310	COG3152	Membrane
I5M57_23315	COG0583	DNA-binding transcription factor activity
I5M57_23320	COG1741	Belongs to the pirin family
I5M57_23345	COG1929	Belongs to the glycerate kinase type-1 family
I5M57_23350	COG2084	Dehydrogenase
I5M57_23360	COG2271	Major facilitator Superfamily
I5M57_23365	COG2721	sulfolactate sulfo-lyase activity
I5M57_23370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M57_23375	COG1349	DNA-binding transcription factor activity
I5M57_23385	COG1105	Belongs to the carbohydrate kinase PfkB family
I5M57_23390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M57_23390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M57_23390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_23395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_23395	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_23405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_23410	COG3414	Phosphotransferase system galactitol-specific IIB component
I5M57_23415	COG3775	system Galactitol-specific IIC component
I5M57_23420	COG1063	alcohol dehydrogenase
I5M57_23435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I5M57_23455	COG2823	Periplasmic or secreted lipoprotein
I5M57_23460	COG0701	Predicted permease
I5M57_23465	COG0702	epimerase
I5M57_23470	COG0693	protein deglycase activity
I5M57_23485	COG3153	acetyltransferase
I5M57_23490	COG3154	lipid carrier protein
I5M57_23495	COG0826	peptidase U32
I5M57_23500	COG0826	peptidase U32
I5M57_23505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M57_23510	COG0814	amino acid
I5M57_23555	COG0195	Participates in both transcription termination and antitermination
I5M57_23595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5M57_23605	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I5M57_23610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5M57_23620	COG1534	Rna-binding protein
I5M57_23630	COG2027	D-alanyl-D-alanine carboxypeptidase
I5M57_23640	COG0697	spore germination
I5M57_23655	COG0142	geranyltranstransferase activity
I5M57_23660	COG3423	Transcriptional regulator
I5M57_23670	COG5007	Belongs to the BolA IbaG family
I5M57_23675	COG3113	response to antibiotic
I5M57_23680	COG2854	intermembrane phospholipid transfer
I5M57_23685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5M57_23690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5M57_23695	COG1127	ABC transporter
I5M57_23700	COG0530	calcium, potassium:sodium antiporter activity
I5M57_23710	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I5M57_23715	COG3117	lipopolysaccharide transmembrane transporter activity
I5M57_23720	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I5M57_23725	COG1137	ATPase activity
I5M57_23730	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I5M57_23735	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5M57_23740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_23750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M57_23755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5M57_23760	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I5M57_23765	COG5002	protein histidine kinase activity
I5M57_23765	COG0784	Response regulator, receiver
I5M57_23765	COG2198	Histidine kinase
I5M57_23770	COG1312	Catalyzes the dehydration of D-mannonate
I5M57_23775	COG1063	alcohol dehydrogenase
I5M57_23780	COG2271	Major facilitator Superfamily
I5M57_23785	COG1242	4 iron, 4 sulfur cluster binding
I5M57_23790	COG0067	glutamate synthase
I5M57_23790	COG0070	glutamate synthase
I5M57_23790	COG0069	glutamate synthase activity
I5M57_23795	COG0493	'glutamate synthase
I5M57_23805	COG2969	positive regulation of protein catabolic process
I5M57_23810	COG0625	glutathione transferase activity
I5M57_23825	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5M57_23830	COG3105	Protein conserved in bacteria
I5M57_23835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5M57_23840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5M57_23865	COG2732	(Barnase) inhibitor
I5M57_23870	COG1289	transmembrane transporter activity
I5M57_23885	COG0583	DNA-binding transcription factor activity
I5M57_23890	COG0312	modulator of DNA gyrase
I5M57_23895	COG3164	Protein of unknown function
I5M57_23900	COG1530	ribonuclease E activity
I5M57_23910	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I5M57_23915	COG1792	Involved in formation and maintenance of cell shape
I5M57_23920	COG1077	Cell shape determining protein MreB Mrl
I5M57_23925	COG2200	EAL domain
I5M57_23925	COG2199	diguanylate cyclase activity
I5M57_23950	COG0511	ligase activity, forming carbon-carbon bonds
I5M57_23955	COG0439	Biotin carboxylase
I5M57_23960	COG3924	membrane
I5M57_23965	COG4145	pantothenate transmembrane transporter activity
I5M57_23990	COG4626	Terminase
I5M57_23990	COG1802	Transcriptional regulator
I5M57_24075	COG3561	AntA/AntB antirepressor
I5M57_24090	COG0582	viral genome integration into host DNA
I5M57_24095	COG1309	transcriptional regulator
I5M57_24100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M57_24105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M57_24140	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5M57_24160	COG0551	DNA topoisomerase type I activity
I5M57_24170	COG0758	DNA mediated transformation
I5M57_24200	COG3036	rescue of stalled ribosome
I5M57_24205	COG0789	Transcriptional regulator
I5M57_24220	COG0202	RNA polymerase activity
I5M57_24245	COG0201	protein transport
I5M57_24310	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I5M57_24325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I5M57_24350	COG0051	transcription antitermination factor activity, RNA binding
I5M57_24405	COG2964	Protein conserved in bacteria
I5M57_24410	COG0545	Peptidyl-prolyl cis-trans isomerase
I5M57_24420	COG1047	Peptidyl-prolyl cis-trans
I5M57_24425	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I5M57_24440	COG0488	(ABC) transporter
I5M57_24445	COG0429	hydrolase of the alpha beta-hydrolase fold
I5M57_24455	COG3954	Phosphoribulokinase
I5M57_24460	COG1765	OsmC-like protein
I5M57_24470	COG1289	transmembrane transporter activity
I5M57_24475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5M57_24500	COG0738	Major facilitator superfamily
I5M57_24505	COG0402	S-adenosylhomocysteine deaminase activity
I5M57_24510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5M57_24535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5M57_24540	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I5M57_24545	COG3266	domain, Protein
I5M57_24560	COG4796	Type ii and iii secretion system protein
I5M57_24585	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I5M57_24590	COG0494	nUDIX hydrolase
I5M57_24600	COG1011	Hydrolase
I5M57_24605	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5M57_24630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5M57_24635	COG2183	response to ionizing radiation
I5M57_24640	COG1918	ferrous iron import across plasma membrane
I5M57_24665	COG1040	competence protein
I5M57_24675	COG2610	gluconate transmembrane transporter activity
I5M57_24680	COG1640	4-alpha-glucanotransferase
I5M57_24685	COG0058	SHG alpha-glucan phosphorylase activity
I5M57_24695	COG1349	DNA-binding transcription factor activity
I5M57_24710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5M57_24725	COG0058	SHG alpha-glucan phosphorylase activity
I5M57_24750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5M57_24760	COG2610	gluconate transmembrane transporter activity
I5M57_24765	COG3265	gluconokinase activity
I5M57_24770	COG1609	Transcriptional regulator
I5M57_24775	COG1741	Belongs to the pirin family
I5M57_24780	COG0673	inositol 2-dehydrogenase activity
I5M57_24790	COG1247	-acetyltransferase
I5M57_24795	COG0405	Gamma-glutamyltransferase
I5M57_24805	COG0584	glycerophosphoryl diester phosphodiesterase
I5M57_24855	COG0559	Belongs to the binding-protein-dependent transport system permease family
I5M57_24860	COG0683	leucine binding
I5M57_24870	COG0683	leucine binding
I5M57_24880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M57_24895	COG2177	Part of the ABC transporter FtsEX involved in
I5M57_24900	COG2884	Cell division ATP-binding protein ftsE
I5M57_24905	COG0552	protein localization to endoplasmic reticulum
I5M57_24910	COG0742	ribosomal rna small subunit methyltransferase
I5M57_24915	COG3776	membrane
I5M57_24925	COG3714	YhhN family
I5M57_24940	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I5M57_24950	COG0477	Major facilitator Superfamily
I5M57_24955	COG0628	permease
I5M57_24995	COG3479	Phenolic acid decarboxylase
I5M57_25005	COG0747	negative chemotaxis
I5M57_25010	COG0601	transmembrane transport
I5M57_25015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M57_25025	COG1124	(ABC) transporter
I5M57_25035	COG2239	Acts as a magnesium transporter
I5M57_25040	COG2081	HI0933 family
I5M57_25045	COG0306	phosphate transporter
I5M57_25055	COG0589	response to stress
I5M57_25075	COG0671	phosphoesterase, PA-phosphatase related
I5M57_25080	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I5M57_25085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M57_25095	COG1454	alcohol dehydrogenase
I5M57_25105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M57_25110	COG1028	Short-chain dehydrogenase reductase Sdr
I5M57_25115	COG0583	DNA-binding transcription factor activity
I5M57_25120	COG1295	ribonuclease BN
I5M57_25125	COG0477	Major facilitator Superfamily
I5M57_25130	COG2982	Protein involved in outer membrane biogenesis
I5M57_25140	COG0612	Peptidase, M16
I5M57_25150	COG2199	diguanylate cyclase activity
I5M57_25150	COG2200	EAL domain
I5M57_25155	COG0457	Tetratricopeptide repeat
I5M57_25155	COG3118	belongs to the thioredoxin family
I5M57_25160	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I5M57_25165	COG1215	transferase activity, transferring glycosyl groups
I5M57_25195	COG2194	sulfuric ester hydrolase activity
I5M57_25210	COG0457	Tetratricopeptide repeat
I5M57_25215	COG1215	transferase activity, transferring glycosyl groups
I5M57_25240	COG4608	Belongs to the ABC transporter superfamily
I5M57_25245	COG0444	Belongs to the ABC transporter superfamily
I5M57_25250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M57_25255	COG0601	transmembrane transport
I5M57_25260	COG0747	negative chemotaxis
I5M57_25290	COG2223	nitrite transmembrane transporter activity
I5M57_25295	COG5571	outer membrane autotransporter
I5M57_25300	COG2818	Glycosylase
I5M57_25305	COG0456	acetyltransferase
I5M57_25310	COG0243	molybdopterin cofactor binding
I5M57_25315	COG2885	chlorophyll binding
I5M57_25320	COG1609	Transcriptional regulator
I5M57_25330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M57_25350	COG2814	Major facilitator Superfamily
I5M57_25355	COG2944	sequence-specific DNA binding
I5M57_25360	COG1278	Cold shock
I5M57_25395	COG3274	enterobacterial common antigen metabolic process
I5M57_25400	COG4682	membrane
I5M57_25405	COG4682	membrane
I5M57_25420	COG4213	ABC transporter substrate-binding protein
I5M57_25430	COG4214	carbohydrate transport
I5M57_25435	COG2207	Transcriptional regulator
I5M57_25435	COG1609	Transcriptional regulator
I5M57_25440	COG2992	FlgJ-related protein
I5M57_25445	COG0366	Alpha amylase catalytic
I5M57_25450	COG3977	Valine--pyruvate aminotransferase
I5M57_25455	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M57_25460	COG1414	Transcriptional regulator
I5M57_25465	COG3276	selenocysteine insertion sequence binding
I5M57_25475	COG0625	glutathione transferase activity
I5M57_25480	COG1566	PFAM secretion protein HlyD family protein
I5M57_25500	COG3722	fumarate hydratase activity
I5M57_25520	COG2186	Transcriptional regulator
I5M57_25530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I5M57_25550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5M57_25555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5M57_25565	COG4942	peptidase
I5M57_25570	COG2861	carbohydrate metabolic process
I5M57_25575	COG0463	Glycosyl transferase, family 2
I5M57_25585	COG0156	8-amino-7-oxononanoate synthase activity
I5M57_25600	COG0859	PFAM glycosyl transferase family 9
I5M57_25625	COG0859	PFAM glycosyl transferase family 9
I5M57_25635	COG0438	transferase activity, transferring glycosyl groups
I5M57_25640	COG1216	Glycosyl transferase, family 2
I5M57_25645	COG1519	Transferase
I5M57_25680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5M57_25705	COG0842	Transport permease protein
I5M57_25710	COG1131	(ABC) transporter
I5M57_25730	COG3039	Transposase
I5M57_25745	COG1561	YicC-like family, N-terminal region
I5M57_25750	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I5M57_25755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5M57_25755	COG2169	Transcriptional regulator
I5M57_25765	COG2860	membrane
I5M57_25785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5M57_25790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M57_25795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5M57_25800	COG1494	fructose-1,6-bisphosphatase
I5M57_25810	COG3152	Membrane
I5M57_25835	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I5M57_25855	COG0786	glutamate:sodium symporter activity
I5M57_25860	COG2233	PERMEase
I5M57_25865	COG2982	Protein involved in outer membrane biogenesis
I5M57_25870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M57_25870	COG1263	PTS System
I5M57_25875	COG1486	melibiose metabolic process
I5M57_25885	COG1501	Belongs to the glycosyl hydrolase 31 family
I5M57_25890	COG2211	Major facilitator Superfamily
I5M57_25920	COG1064	alcohol dehydrogenase
I5M57_25930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I5M57_25945	COG1464	Belongs to the NlpA lipoprotein family
I5M57_25970	COG0583	DNA-binding transcription factor activity
I5M57_26005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M57_26015	COG2814	Major facilitator Superfamily
I5M57_26025	COG1263	PTS System
I5M57_26025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M57_26030	COG0697	spore germination
I5M57_26045	COG2828	Protein conserved in bacteria
I5M57_26050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5M57_26055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5M57_26060	COG0583	DNA-binding transcription factor activity
I5M57_26065	COG3384	dioxygenase
I5M57_26075	COG1609	Transcriptional regulator
I5M57_26085	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M57_26085	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M57_26090	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M57_26095	COG4580	involved in the transport of maltose and maltodextrins
I5M57_26120	COG2188	Transcriptional regulator
I5M57_26160	COG2271	Major facilitator Superfamily
I5M57_26170	COG2197	response regulator
I5M57_26175	COG0440	acetolactate synthase activity
I5M57_26180	COG0028	Belongs to the TPP enzyme family
I5M57_26210	COG2814	Major facilitator Superfamily
I5M57_26215	COG0583	DNA-binding transcription factor activity
I5M57_26225	COG2610	gluconate transmembrane transporter activity
I5M57_26245	COG2149	membrane
I5M57_26260	COG2188	Transcriptional regulator
I5M57_26270	COG3645	SOS response
I5M57_26285	COG5645	(Lipo)protein
I5M57_26290	COG0823	Involved in the tonB-independent uptake of proteins
I5M57_26295	COG2271	Major facilitator Superfamily
I5M57_26315	COG0800	Aldolase
I5M57_26320	COG3734	2-keto-3-deoxy-galactonokinase
I5M57_26325	COG2186	Transcriptional regulator
I5M57_26340	COG0561	phosphatase activity
I5M57_26345	COG0187	DNA topoisomerase II activity
I5M57_26375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I5M57_26405	COG2091	lysine biosynthetic process via aminoadipic acid
I5M57_26410	COG0431	NADPH-dependent FMN reductase
I5M57_26415	COG2252	PERMEase
I5M57_26420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M57_26425	COG0363	glucosamine-6-phosphate deaminase activity
I5M57_26430	COG2382	esterase
I5M57_26440	COG0704	Plays a role in the regulation of phosphate uptake
I5M57_26445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5M57_26450	COG0581	inorganic phosphate transmembrane transporter activity
I5M57_26455	COG0573	inorganic phosphate transmembrane transporter activity
I5M57_26460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I5M57_26465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5M57_26515	COG3312	ion transport
I5M57_26530	COG0716	FMN binding
I5M57_26535	COG1522	sequence-specific DNA binding
I5M57_26565	COG1129	ABC transporter
I5M57_26570	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M57_26580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M57_26585	COG1609	Transcriptional regulator
I5M57_26590	COG0477	Major facilitator Superfamily
I5M57_26595	COG2186	Transcriptional regulator
I5M57_26620	COG1763	Mo-molybdopterin cofactor biosynthetic process
I5M57_26630	COG3084	Protein conserved in bacteria
I5M57_26635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5M57_26645	COG0204	Acyl-transferase
I5M57_26665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5M57_26680	COG3852	Histidine kinase
I5M57_26695	COG1011	Hydrolase
I5M57_26710	COG0456	acetyltransferase
I5M57_26715	COG0657	acetylesterase activity
I5M57_26720	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I5M57_26735	COG2864	formate dehydrogenase
I5M57_26740	COG0437	4 iron, 4 sulfur cluster binding
I5M57_26760	COG0205	6-phosphofructokinase activity
I5M57_26820	COG2211	Major facilitator Superfamily
I5M57_26830	COG1454	alcohol dehydrogenase
I5M57_26835	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M57_26840	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M57_26845	COG1129	ABC transporter
I5M57_26885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I5M57_26890	COG2258	MOSC domain
I5M57_26895	COG2205	protein histidine kinase activity
I5M57_26900	COG0745	RESPONSE REGULATOR receiver
I5M57_26905	COG3678	ATP-independent chaperone mediated protein folding
I5M57_26925	COG1575	Belongs to the MenA family. Type 1 subfamily
I5M57_26940	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5M57_26945	COG1609	Transcriptional regulator
I5M57_26950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5M57_26965	COG0626	cystathionine gamma-synthase activity
I5M57_26970	COG0460	homoserine dehydrogenase
I5M57_26970	COG0527	aspartate kinase activity
I5M57_26980	COG0737	Belongs to the 5'-nucleotidase family
I5M57_26990	COG0583	DNA-binding transcription factor activity
I5M57_27000	COG0697	spore germination
I5M57_27005	COG0371	Dehydrogenase
I5M57_27015	COG2207	Transcriptional regulator
I5M57_27020	COG3443	Belongs to the bacterial solute-binding protein 9 family
I5M57_27035	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I5M57_27050	COG0583	DNA-binding transcription factor activity
I5M57_27180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5M57_27245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M57_27290	COG1660	Displays ATPase and GTPase activities
I5M57_27345	COG1192	Involved in chromosome partitioning
I5M57_27430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5M57_27530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5M57_27555	COG5001	Diguanylate cyclase
I5M57_27590	COG0714	Associated with various cellular activities
I5M57_27600	COG0629	single-stranded DNA binding
I5M57_27645	COG0633	Ferredoxin
I5M57_27815	COG4974	Belongs to the 'phage' integrase family
I5M57_27940	COG0616	signal peptide processing
I5M57_27985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I5M57_28065	COG3344	reverse transcriptase
I5M57_28210	COG5001	Diguanylate cyclase
I5M57_28210	COG3300	MHYT domain
I5M57_28355	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I5M57_28425	COG3039	Transposase
I5M57_28480	COG2135	peptidase activity