locus-tag class description FEE38_00130 ENOG4108BUD transposase FEE38_00295 ENOG4108BUD transposase FEE38_00355 ENOG4108R0M Aminoglycoside FEE38_00375 ENOG4105EQR Transposase IS116 IS110 IS902 FEE38_00390 ENOG4108BUD transposase FEE38_00455 ENOG4105C5H ABC transporter FEE38_00470 ENOG4107R1I NAD-dependent malic enzyme FEE38_00485 ENOG4105JQN Transcriptional regulator FEE38_00490 ENOG4105N0E Protein of unknown function (DUF2543) FEE38_00495 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FEE38_00515 ENOG4108N8X transition metal ion binding FEE38_00525 ENOG4105CG3 alpha amylase, catalytic region FEE38_00545 ENOG4108YDI single-species biofilm formation on inanimate substrate FEE38_00550 ENOG4108Z9K Osmotically inducible protein FEE38_00575 ENOG4105FFC UPF0187 protein FEE38_00580 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FEE38_00585 ENOG4105C5Q Transcriptional regulator FEE38_00590 ENOG4108KUU Inner membrane metabolite transport protein ydjE FEE38_00600 ENOG4105KT7 mgtC SapB transporter FEE38_00605 ENOG4105D6Z AFG1 family ATPase FEE38_00610 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FEE38_00615 ENOG4106KR7 LysR family Transcriptional regulator FEE38_00635 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FEE38_00645 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E FEE38_00655 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) FEE38_00660 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) FEE38_00670 ENOG4108IGT Dipeptidase FEE38_00675 ENOG4108J2P Alpha beta hydrolase fold FEE38_00685 ENOG4105E0F Histidine kinase FEE38_00705 ENOG4105DY8 decarboxylase FEE38_00710 ENOG4108JPW Aminotransferase FEE38_00715 ENOG4107Z6I Thiamine biosynthesis protein FEE38_00720 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component FEE38_00725 ENOG4108YI8 ABC transporter FEE38_00730 ENOG4105ETU transcriptional activator (TenA FEE38_00740 ENOG4105CIB oxidoreductase Domain protein FEE38_00750 ENOG4105ETE Transcriptional regulator (LacI family FEE38_00755 ENOG4105BZU Histidine kinase FEE38_00760 ENOG4107QUY Guanine deaminase FEE38_00765 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FEE38_00800 ENOG4105CVJ phosphoglycerate mutase FEE38_00810 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FEE38_00825 ENOG41089BK Glutamine amido-transferase FEE38_00830 ENOG4105R1U AraC Family Transcriptional Regulator FEE38_00850 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FEE38_00870 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FEE38_00895 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FEE38_00915 ENOG4105E5Q amino acid AbC transporter FEE38_00925 ENOG4105C5R Aminotransferase FEE38_00940 ENOG4105CBN LysR family transcriptional regulator FEE38_00950 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FEE38_00955 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain FEE38_00960 ENOG4105CSH Transporter FEE38_01005 ENOG4105FCD Major Facilitator FEE38_01015 ENOG4105ETE Transcriptional regulator (LacI family FEE38_01020 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FEE38_01030 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC FEE38_01035 ENOG4105UP7 3-epimerase FEE38_01045 ENOG4108YRF PTS System FEE38_01050 ENOG4105DM4 PTS System FEE38_01055 ENOG410829K Lysine exporter protein (Lyse ygga) FEE38_01070 ENOG4105CBN LysR family transcriptional regulator FEE38_01075 ENOG4105HEI LysR family (Transcriptional regulator FEE38_01090 ENOG4107PP3 Acetylornithine deacetylase FEE38_01105 ENOG4105CNN ABC, transporter FEE38_01110 ENOG4105C2J ABC transporter FEE38_01115 ENOG4105ETE Transcriptional regulator (LacI family FEE38_01145 ENOG4109066 lysm domain bon superfamily protein FEE38_01150 ENOG4105CXY transporter FEE38_01155 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC FEE38_01165 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta FEE38_01170 ENOG4105RHY Pfam:UPF0157 FEE38_01175 ENOG4105EQ2 LysR family Transcriptional regulator FEE38_01275 ENOG4105ENX hydrolase FEE38_01290 ENOG4105MVE transcriptional regulator FEE38_01295 ENOG4105CMG Carbohydrate kinase FEE38_01300 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FEE38_01305 ENOG4105E98 transcriptional regulator DeoR family FEE38_01310 ENOG4105UP7 3-epimerase FEE38_01315 ENOG4108RVA ribokinase FEE38_01320 ENOG4105EDR glucose galactose transporter FEE38_01335 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) FEE38_01340 ENOG4105CHR reductase FEE38_01345 ENOG4105CHU acetyl-coa acetyltransferase FEE38_01365 ENOG4105BZW Glycerate kinase FEE38_01370 ENOG4107VHA regulatoR FEE38_01390 ENOG4107YCY Transcriptional regulator FEE38_01395 ENOG4105CI1 PTS System FEE38_01405 ENOG4105F8D glycoside hydrolase family 4 FEE38_01415 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FEE38_01425 ENOG4105NIV Esterase FEE38_01430 ENOG4105BZU Histidine kinase FEE38_01445 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FEE38_01460 ENOG4108VCD Chaperone FEE38_01465 ENOG4105CW0 outer membrane usher protein FEE38_01480 ENOG4105F32 YngK protein FEE38_01485 ENOG4105CAF HipA N-terminal domain protein FEE38_01490 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein FEE38_01495 ENOG4105VT2 5-hydroxyisourate hydrolase FEE38_01500 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) FEE38_01505 ENOG4105C2W permease FEE38_01510 ENOG41061H0 Monooxygenase FEE38_01515 ENOG4108KSA LysR family transcriptional regulator FEE38_01535 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions FEE38_01550 ENOG4105VYA Uncharacterized conserved protein (DUF2132) FEE38_01560 ENOG4105D01 (LipO)protein FEE38_01570 ENOG4108UMI ABC transporter, permease FEE38_01575 ENOG4105EA8 2-Nitropropane dioxygenase FEE38_01580 ENOG4105EGI Transcriptional regulator FEE38_01585 ENOG4105CBP Major Facilitator FEE38_01600 ENOG4105F9N Major Facilitator Superfamily FEE38_01655 ENOG4107QZW Altronate oxidoreductase FEE38_01665 ENOG4105BZU Histidine kinase FEE38_01670 ENOG4105M0C cytoplasmic protein FEE38_01675 ENOG4105CSV Glutaminase FEE38_01680 ENOG4105C26 Dehydrogenase FEE38_01685 ENOG4105EGI Transcriptional regulator FEE38_01695 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FEE38_01700 ENOG4105MVE transcriptional regulator FEE38_01705 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FEE38_01710 ENOG4107S2N Type III effector Hrp-dependent FEE38_01715 ENOG4105C0A alcohol dehydrogenase FEE38_01720 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FEE38_01725 ENOG4108JQ1 Dehydrogenase FEE38_01735 ENOG4105JAB phenazine biosynthesis protein, phzf family FEE38_01740 ENOG4105F27 Major Facilitator FEE38_01745 ENOG41082NP Multiple antibiotic resistance FEE38_01750 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FEE38_01755 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF FEE38_01760 ENOG4106DNR multiple antibiotic resistance protein FEE38_01765 ENOG4108594 Permease of the drug metabolite transporter FEE38_01770 ENOG4105E5W Transporter FEE38_01780 ENOG4108IV0 ABC, transporter FEE38_01790 ENOG4105CNN ABC, transporter FEE38_01795 ENOG4105C32 Amino acid ABC transporter (Permease) FEE38_01800 ENOG41083Z3 extracellular ligand-binding receptor FEE38_01815 ENOG4105ECQ AraC Family Transcriptional Regulator FEE38_01830 ENOG4105ETE Transcriptional regulator (LacI family FEE38_01835 ENOG4105CNT hydrolase family 2 FEE38_01840 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FEE38_01845 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FEE38_01860 ENOG4105MVE transcriptional regulator FEE38_01875 ENOG4105G63 Type III effector Hrp-dependent FEE38_01880 ENOG4105FB2 class II Aldolase FEE38_01885 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FEE38_01890 ENOG4105C6Z Gluconate FEE38_01915 ENOG4105BZU Histidine kinase FEE38_01920 ENOG4108WTK competence damage-inducible protein FEE38_01925 ENOG4108ZNX Heat shock protein FEE38_01950 ENOG4108RAV Conserved protein FEE38_01955 ENOG4105R1U AraC Family Transcriptional Regulator FEE38_01965 ENOG4105DGW oligopeptidase A FEE38_01970 ENOG4105EMU Dehydrogenase FEE38_01975 ENOG4107XBN GntR Family Transcriptional Regulator FEE38_01980 ENOG4108U51 Universal stress protein FEE38_01985 ENOG4105DEI Mannitol dehydrogenase FEE38_01990 ENOG4108I5G Major Facilitator superfamily FEE38_01995 ENOG4105KK4 UPF0060 membrane protein FEE38_02000 ENOG4105M5Q UPF0482 protein FEE38_02005 ENOG4108MK9 spermidine N(1)-acetyltransferase FEE38_02015 ENOG4105KBG Protein of unknown function (DUF1161) FEE38_02025 ENOG4105QAX Iron-sulfur FEE38_02030 ENOG4107KGK dmso reductase anchor subunit FEE38_02035 ENOG4108NEM leader-binding protein dmsD FEE38_02040 ENOG4105CMQ Chloride channel FEE38_02045 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FEE38_02050 ENOG4105DAG ROK family FEE38_02055 ENOG4106NZI LysR family Transcriptional regulator FEE38_02060 ENOG4105D94 Major Facilitator Superfamily FEE38_02065 ENOG4105CTD carboxy-peptidase FEE38_02075 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap FEE38_02085 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) FEE38_02090 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) FEE38_02095 ENOG4105DSF transport protein FEE38_02125 ENOG4107TT2 Auxin Efflux Carrier FEE38_02130 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase FEE38_02135 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FEE38_02140 ENOG4108K70 Transcriptional regulator FEE38_02145 ENOG4105DWT malate dehydrogenase (quinone) FEE38_02150 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FEE38_02160 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FEE38_02165 ENOG4108MRH transcriptional regulatory protein FEE38_02185 ENOG4107GFK fumarate FEE38_02195 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FEE38_02200 ENOG4105F2Z 3-oxoadipate enol-lactonase FEE38_02205 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FEE38_02210 ENOG4105CHU acetyl-coa acetyltransferase FEE38_02215 ENOG4107QNJ CoA-transferase subunit B FEE38_02225 ENOG4107HP6 Transcriptional regulator FEE38_02230 ENOG4108DG9 Smr protein MutS2 FEE38_02235 ENOG4106KR7 LysR family Transcriptional regulator FEE38_02245 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B FEE38_02250 ENOG4105CFC Transporter FEE38_02260 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FEE38_02265 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FEE38_02270 ENOG4105Q9Y Universal stress protein FEE38_02275 ENOG410671Z uncharacterized protein ydiH FEE38_02280 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FEE38_02285 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FEE38_02295 ENOG4105C5D exported protein FEE38_02305 ENOG4105D5Q Arginine ornithine antiporter FEE38_02310 ENOG410642E Short chain dehydrogenase FEE38_02315 ENOG4105RA2 Membrane FEE38_02320 ENOG4107EXC regulatoR FEE38_02330 ENOG4105JJR Histidine kinase FEE38_02340 ENOG4105C9Q fumarate hydratase class II FEE38_02345 ENOG4107GFK fumarate FEE38_02350 ENOG4105EIP mannose-6-phosphate isomerase FEE38_02355 ENOG4106J39 exported protein FEE38_02360 ENOG4107P2S Transcriptional regulator FEE38_02365 ENOG4105CI1 PTS System FEE38_02370 ENOG4107TII Recombinase FEE38_02445 ENOG4105CI1 PTS System FEE38_02450 ENOG4105C87 Aminotransferase class I and II FEE38_02460 ENOG41061EV selenium-binding protein YdfZ FEE38_02475 ENOG41066VF YeeE YedE family protein FEE38_02485 ENOG41064WM Uncharacterized protein YcgX FEE38_02490 ENOG4105VPI YqaE family transport protein FEE38_02495 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FEE38_02500 ENOG4105C26 Dehydrogenase FEE38_02505 ENOG4107DB1 DUF218 domain FEE38_02520 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) FEE38_02525 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) FEE38_02530 ENOG4105C26 Dehydrogenase FEE38_02535 ENOG4105F4X arginine FEE38_02540 ENOG4105C8Y Acetylornithine aminotransferase FEE38_02545 ENOG4105D82 Glutamate dehydrogenase FEE38_02550 ENOG4108FN7 Aldo keto reductase FEE38_02555 ENOG410642W LysR family Transcriptional regulator FEE38_02575 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FEE38_02585 ENOG4105CQ7 ATP-dependent helicase FEE38_02590 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FEE38_02600 ENOG4108Z0R Transferase FEE38_02605 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FEE38_02610 ENOG4105DZS Phenylacetate-CoA ligase FEE38_02615 ENOG4105CHU acetyl-coa acetyltransferase FEE38_02620 ENOG4108ZJI phenylacetic acid degradation protein FEE38_02625 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FEE38_02630 ENOG4108UKI Enoyl-CoA hydratase FEE38_02635 ENOG4105E39 Enoyl-CoA hydratase FEE38_02640 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FEE38_02645 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FEE38_02650 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FEE38_02655 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FEE38_02660 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FEE38_02665 ENOG4105DXM phenylacetic acid degradation protein FEE38_02670 ENOG4105F11 amine oxidase FEE38_02685 ENOG4105CWC Acetylornithine deacetylase FEE38_02695 ENOG4105KME endoribonuclease L-psp FEE38_02700 ENOG4105H3G oxidoreductase FEE38_02705 ENOG4108KB2 LysR family Transcriptional regulator FEE38_02725 ENOG4105EAB amino acid AbC transporter FEE38_02740 ENOG4105C26 Dehydrogenase FEE38_02745 ENOG4108WFR AraC Family Transcriptional Regulator FEE38_02750 ENOG4105WXT Conserved Protein FEE38_02755 ENOG410689M (LipO)protein FEE38_02760 ENOG4107H52 Dicarboxylate transport FEE38_02765 ENOG4108KF1 Membrane FEE38_02770 ENOG4105C5I Dehydrogenase FEE38_02775 ENOG41090X5 Heat shock protein hslJ FEE38_02780 ENOG4105IKK cytoplasmic protein FEE38_02790 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) FEE38_02795 ENOG4105FCK Membrane FEE38_02805 ENOG4108RW8 Universal stress protein F FEE38_02815 ENOG4105C1J atp-dependent rna helicase FEE38_02820 ENOG4107RX3 Mg2 transporter protein cora family protein FEE38_02830 ENOG4105E98 transcriptional regulator DeoR family FEE38_02835 ENOG4105D9R oxidoreductase FEE38_02850 ENOG4105C85 amino acid FEE38_02855 ENOG4105F7P transcriptional regulator AsnC family FEE38_02865 ENOG4105CGF Aromatic amino acid aminotransferase FEE38_02870 ENOG4108UMI ABC transporter, permease FEE38_02880 ENOG4105D01 (LipO)protein FEE38_02915 ENOG4105HEI LysR family (Transcriptional regulator FEE38_02940 ENOG4108XFH Transcriptional regulator FEE38_02945 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FEE38_03015 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FEE38_03025 ENOG4108ZG0 Ompa motb domain protein FEE38_03050 ENOG4108Z0Z intracellular protease Pfpi family FEE38_03075 ENOG4105CBN LysR family transcriptional regulator FEE38_03100 ENOG4107RTG Major Facilitator superfamily FEE38_03105 ENOG4105ENX hydrolase FEE38_03110 ENOG4105EQ2 LysR family Transcriptional regulator FEE38_03175 ENOG4107QSI ABC, transporter FEE38_03180 ENOG4105KXI murein peptide amidase A FEE38_03185 ENOG4107S8C mandelate racemase muconate lactonizing FEE38_03190 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FEE38_03195 ENOG4108KK1 membrane protein AbrB duplication FEE38_03200 ENOG4108JU8 Transcriptional regulator FEE38_03205 ENOG4105F8D glycoside hydrolase family 4 FEE38_03210 ENOG4105W8I Transcriptional regulator FEE38_03215 ENOG4106K28 UPF0283 membrane protein FEE38_03220 ENOG4105CM6 amino acid regulated cytosolic protein FEE38_03225 ENOG4105NNG Peripheral inner membrane phage-shock protein FEE38_03230 ENOG4105FM1 phage shock protein C FEE38_03235 ENOG4105YYT phage shock protein B FEE38_03240 ENOG41087YS Phage shock protein A FEE38_03245 ENOG4105E51 psp operon transcriptional activator FEE38_03255 ENOG4105CH2 amidohydrolase FEE38_03260 ENOG41063ZK Transcriptional Regulator AraC Family FEE38_03275 ENOG4108J59 Extracellular solute-binding protein, family 5 FEE38_03280 ENOG4108EKA peptide transport system, permease FEE38_03295 ENOG4106IAW FEE38_03300 ENOG4105VEQ Cold shock protein FEE38_03305 ENOG41060EU Cold shock-like protein FEE38_03310 ENOG4105E2V Glycosyltransferase 36 FEE38_03315 ENOG4105E5H Transposase FEE38_03320 ENOG4108YXQ IS66 Orf2 family protein FEE38_03330 ENOG4105W3V DNA-binding, transcriptional regulator FEE38_03340 ENOG4105D1S lipid A biosynthesis FEE38_03345 ENOG4108C33 Resolvase FEE38_03660 ENOG4105UVW uncharacterized protein yebW FEE38_03670 ENOG41076J9 exonuclease VIII FEE38_03705 ENOG4108EU3 peptide transport system, permease FEE38_03710 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein FEE38_03715 ENOG4108JQ2 peptide transport system atp-binding protein FEE38_03720 ENOG4105ETS cytosine purines uracil thiamine allantoin FEE38_03730 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FEE38_03735 ENOG4105Q4T oxidoreductase FEE38_03740 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) FEE38_03750 ENOG4105N2W Transcriptional regulator FEE38_03755 ENOG41061RM osmotically inducible lipoprotein FEE38_03760 ENOG4108ZJT translation initiation factor, Sui1 FEE38_03770 ENOG4105CFV Tetratricopeptide repeat protein FEE38_03775 ENOG4105Q4A inner membrane protein yciS FEE38_03780 ENOG4105EYK Phosphatidylglycerophosphatase B FEE38_03785 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FEE38_03790 ENOG4107QM5 aconitate hydratase FEE38_03800 ENOG4107R11 Transcriptional regulator FEE38_03805 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FEE38_03810 ENOG4105RKX Protein of unknown function (DUF2498) FEE38_03815 ENOG4105ERU peptidase FEE38_03825 ENOG4105UBK short-chain dehydrogenase reductase FEE38_03830 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FEE38_03840 ENOG4105ETT transcriptional Regulator, LysR family FEE38_03850 ENOG4107RTD sua5 ycio yrdc ywlc family protein FEE38_03855 ENOG4105DB7 PHP domain protein FEE38_03860 ENOG4105CRQ synthase (Component I) FEE38_03865 ENOG4108EFP Anthranilate synthase component II FEE38_03870 ENOG4105DK0 Indole-3-glycerol phosphate synthase FEE38_03875 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FEE38_03880 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FEE38_03925 ENOG4108IU3 tonb-dependent siderophore receptor FEE38_03930 ENOG4107E2E PKHD-type hydroxylase FEE38_03935 ENOG4105EIF outer membrane protein W FEE38_03940 ENOG4105PI0 Ferredoxin FEE38_03945 ENOG4108S3I UPF0259 membrane protein FEE38_03950 ENOG4107835 probably involved in intracellular septation (By similarity) FEE38_03955 ENOG4107RNH Outer membrane receptor FepA FEE38_03960 ENOG4105NAU thioesterase Superfamily protein FEE38_03965 ENOG4107PN8 YfeABCD locus regulator FEE38_03970 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FEE38_03980 ENOG4107K5X Membrane-bound metal-dependent hydrolase FEE38_03985 ENOG4108ETY sodium dicarboxylate symporter FEE38_03990 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) FEE38_03995 ENOG4105CH6 catalase FEE38_04000 ENOG410901P UPF0249 protein FEE38_04005 ENOG4105F8D glycoside hydrolase family 4 FEE38_04010 ENOG4105EZV Transcriptional regulator FEE38_04015 ENOG4105VCP PTS System FEE38_04020 ENOG4105CK1 PTS System FEE38_04025 ENOG4105VZJ PTS System FEE38_04030 ENOG4105KKI DNA-binding transcriptional activator OsmE FEE38_04040 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) FEE38_04045 ENOG4108SPG Periplasmic Protein FEE38_04055 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) FEE38_04060 ENOG4105C26 Dehydrogenase FEE38_04065 ENOG4105F4X arginine FEE38_04075 ENOG4105CGK Exodeoxyribonuclease III FEE38_04080 ENOG4108RSN SNARE associated Golgi FEE38_04085 ENOG4108N5C SNARE associated Golgi protein-related protein FEE38_04090 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FEE38_04095 ENOG4105VNH ABC transporter solute-binding protein FEE38_04100 ENOG4105CXZ ABC transporter, permease FEE38_04105 ENOG4108VGW abc transporter atp-binding protein FEE38_04110 ENOG4107RM6 sulfurtransferase FEE38_04115 ENOG4108T9J Cdp-alcohol phosphatidyltransferase FEE38_04120 ENOG4105M6F mutator MutT protein FEE38_04125 ENOG4105D82 Glutamate dehydrogenase FEE38_04135 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FEE38_04140 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) FEE38_04145 ENOG4105SBG acid phosphatase FEE38_04150 ENOG41069NU Nitroreductase FEE38_04155 ENOG4105D07 Signal peptide peptidase, SppA FEE38_04160 ENOG4105HDK L-asparaginase FEE38_04165 ENOG4108RWI nicotinamidase FEE38_04170 ENOG4108KUU Inner membrane metabolite transport protein ydjE FEE38_04180 ENOG4105E98 transcriptional regulator DeoR family FEE38_04185 ENOG4105CPC Aldo Keto reductase FEE38_04190 ENOG4107UH8 sugar kinase FEE38_04195 ENOG4105D2N Aldolase FEE38_04200 ENOG4105CPQ Dehydrogenase FEE38_04205 ENOG4107TE1 transport protein FEE38_04210 ENOG4105CPQ Dehydrogenase FEE38_04220 ENOG4105N1F Hnh endonuclease FEE38_04225 ENOG4105VUT cytoplasmic protein FEE38_04230 ENOG4105E0X reductase FEE38_04235 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FEE38_04240 ENOG4105DSB aldose 1-epimerase FEE38_04245 ENOG4105CV8 reductase FEE38_04250 ENOG4105GNX MltA-interacting MipA family protein FEE38_04255 ENOG4105CYN Serine protein kinase FEE38_04260 ENOG4106AKX UPF0229 protein FEE38_04270 ENOG4108V06 Glutathione peroxidase FEE38_04285 ENOG4105F27 Major Facilitator FEE38_04290 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FEE38_04295 ENOG4105CBN LysR family transcriptional regulator FEE38_04300 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FEE38_04305 ENOG4105KT5 UmuD protein FEE38_04310 ENOG4105Y50 Virulence Protein FEE38_04315 ENOG4108XNZ glycosyl transferase FEE38_04320 ENOG4108KXH Ybak prolyl-tRNA synthetase associated FEE38_04325 ENOG4108VMM UPF0756 membrane protein FEE38_04330 ENOG4105R1U AraC Family Transcriptional Regulator FEE38_04335 ENOG4105DJ2 Major Facilitator Superfamily FEE38_04340 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FEE38_04345 ENOG4105EWC Purine nucleoside phosphorylase FEE38_04350 ENOG4105K78 MarR family Transcriptional regulator FEE38_04355 ENOG4105UCG Domain of unknown function (DUF333) FEE38_04360 ENOG410620I Diguanylate cyclase FEE38_04365 ENOG4106G4W FEE38_04380 ENOG4105S5I Membrane FEE38_04385 ENOG4108NIW Leucine export protein LeuE FEE38_04390 ENOG4105D1S lipid A biosynthesis FEE38_04400 ENOG4105DHT Metal Dependent Phosphohydrolase FEE38_04405 ENOG4106TD9 Diguanylate cyclase FEE38_04410 ENOG4107RSM transcriptional regulator FEE38_04415 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FEE38_04440 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FEE38_04445 ENOG4105C4M (Ubiquinol oxidase) subunit I FEE38_04450 ENOG4105WEF catalase FEE38_04455 ENOG4108N8X transition metal ion binding FEE38_04460 ENOG4108Z9Z response to DNA damage stimulus FEE38_04470 ENOG4105E2A Dehydrogenase FEE38_04475 ENOG4105XDF Protein of unknown function (DUF1272) FEE38_04495 ENOG4108ZHR arsR family transcriptional regulator FEE38_04500 ENOG4108HMX isocitrate dehydrogenase (NADP) FEE38_04515 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FEE38_04520 ENOG41075W9 High frequency lysogenization protein HflD homolog FEE38_04525 ENOG4107QTF adenylosuccinate lyase FEE38_04545 ENOG4105IFJ Histidine kinase FEE38_04550 ENOG4105EZE Cupin 4 family protein FEE38_04570 ENOG4105D38 putrescine abc transporter FEE38_04575 ENOG4108HM4 ABC transporter FEE38_04585 ENOG4105CEY Amp-dependent synthetase and ligase FEE38_04590 ENOG4105CV1 Transketolase (EC 2.2.1.1) FEE38_04595 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FEE38_04600 ENOG4108YZG isomerase FEE38_04605 ENOG4105VI0 Pts system, glucitol sorbitol-specific FEE38_04610 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) FEE38_04615 ENOG4105G63 Type III effector Hrp-dependent FEE38_04630 ENOG4105DKT Transcriptional regulator FEE38_04640 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FEE38_04645 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) FEE38_04650 ENOG4105D60 lipoprotein releasing system transmembrane protein FEE38_04655 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FEE38_04660 ENOG4105D60 lipoprotein releasing system transmembrane protein FEE38_04665 ENOG4108JA2 transcriptioN-repair coupling factor FEE38_04670 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FEE38_04675 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction FEE38_04680 ENOG4108IND Tetr family transcriptional regulator FEE38_04690 ENOG4107MBR 17 kDa surface antigen FEE38_04695 ENOG4105CEP NADH dehydrogenase FEE38_04700 ENOG4105D0Y UPF0227 protein FEE38_04715 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) FEE38_04720 ENOG41090DQ Lipoprotein FEE38_04725 ENOG4105K59 histidine triad (HIT) protein FEE38_04730 ENOG4105CI1 PTS System FEE38_04735 ENOG4105F8V Hydrolase, tatD family FEE38_04740 ENOG4107QRG dna polymerase iii FEE38_04745 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FEE38_04750 ENOG4105HHA aminodeoxychorismate lyase FEE38_04755 ENOG4105YAZ 4-amino-4-deoxychorismate lyase FEE38_04760 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FEE38_04765 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FEE38_04770 ENOG4105CHR reductase FEE38_04775 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FEE38_04780 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FEE38_04785 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FEE38_04790 ENOG4105VGS 50s ribosomal protein l32 FEE38_04795 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FEE38_04800 ENOG4108UHJ MAF-like protein FEE38_04805 ENOG4105EI2 Pseudouridine synthase FEE38_04810 ENOG4107QQB Ribonuclease E FEE38_04815 ENOG4105CR8 Transcriptional regulator FEE38_04820 ENOG4105EQ0 Major Facilitator superfamily FEE38_04825 ENOG4105CJR Integral membrane protein (MviN FEE38_04830 ENOG4105EP9 oxidoreductase FEE38_04835 ENOG4108YXG UPF0502 protein FEE38_04840 ENOG4105D9U N-acetyltransferase FEE38_04845 ENOG4105EV4 Multidrug resistance protein mdtH FEE38_04850 ENOG4105F3T (LipO)protein FEE38_04855 ENOG4105EKE dihydroorotase FEE38_04860 ENOG4105MEA DNA damage-inducible protein i FEE38_04870 ENOG4105PVA Biofilm formation regulatory protein BssS FEE38_04880 ENOG4106974 biofilm formation FEE38_04890 ENOG4105D1S lipid A biosynthesis FEE38_04900 ENOG4108W47 Acidic protein msyB FEE38_04905 ENOG4105NAC (LipO)protein FEE38_04910 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) FEE38_04920 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) FEE38_04935 ENOG4108UQ5 membrane protein YcdZ FEE38_04940 ENOG4107XHZ cytoplasmic chaperone TorD family protein FEE38_04950 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FEE38_04960 ENOG4105HEI LysR family (Transcriptional regulator FEE38_04965 ENOG4105EUB pirin domain protein FEE38_04970 ENOG4105CHJ isochorismatase hydrolase FEE38_04985 ENOG4105D5M phosphate starvation-inducible protein FEE38_04990 ENOG4105DBE peroxidase FEE38_04995 ENOG410650H (LipO)protein FEE38_05005 ENOG4105D9N nucleoside FEE38_05015 ENOG4105CK7 Sodium proline symporter FEE38_05020 ENOG4105C26 Dehydrogenase FEE38_05030 ENOG4108R86 Transcriptional regulator FEE38_05035 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) FEE38_05040 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FEE38_05045 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) FEE38_05050 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FEE38_05055 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FEE38_05060 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FEE38_05065 ENOG4105C2W permease FEE38_05075 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 FEE38_05085 ENOG4105XH3 FEE38_05090 ENOG4105D6F Phosphatase FEE38_05100 ENOG4105CHR reductase FEE38_05115 ENOG4105CUB amino acid FEE38_05125 ENOG4105CFQ glutamine synthetase FEE38_05130 ENOG4108Z86 Glutamine amidotransferase FEE38_05135 ENOG4107VRI Transcriptional regulator FEE38_05140 ENOG4105C26 Dehydrogenase FEE38_05145 ENOG4105CJP fad dependent oxidoreductase FEE38_05150 ENOG4105EJC lysr family transcriptional regulator FEE38_05155 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FEE38_05160 ENOG4105C94 Transporter FEE38_05165 ENOG4105DVW rieske (2Fe-2S) FEE38_05170 ENOG4105C26 Dehydrogenase FEE38_05175 ENOG4105E3J oxidoreductase FEE38_05185 ENOG4105BZU Histidine kinase FEE38_05200 ENOG4107QSI ABC, transporter FEE38_05205 ENOG4108MN8 Membrane FEE38_05215 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FEE38_05220 ENOG4108UQN AraC family transcriptional regulator FEE38_05225 ENOG4108V1U phospholipid-binding protein FEE38_05230 ENOG4105DR4 Methyltransferase FEE38_05235 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) FEE38_05240 ENOG4105K4P CoA-binding domain protein FEE38_05250 ENOG41088T4 Helicase IV FEE38_05255 ENOG410901E Membrane FEE38_05260 ENOG4105EM2 membrane FEE38_05265 ENOG4108RZ1 DNA transformation protein FEE38_05275 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) FEE38_05280 ENOG4105UYK outer membrane protein a FEE38_05285 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) FEE38_05290 ENOG4105DAN ATP-dependent protease FEE38_05295 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) FEE38_05300 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) FEE38_05305 ENOG4108Q2G (LipO)protein FEE38_05310 ENOG4105DY2 Paraquat-inducible protein b FEE38_05315 ENOG4105F1S paraquat-inducible protein a FEE38_05320 ENOG4105C5H ABC transporter FEE38_05325 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FEE38_05330 ENOG4105QVC MOSC domain-containing protein FEE38_05335 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) FEE38_05345 ENOG4108UZX fmn reductase FEE38_05350 ENOG4105GVF (ABC) transporter FEE38_05355 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FEE38_05360 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FEE38_05370 ENOG4105CD8 aminopeptidase N FEE38_05375 ENOG4107RH7 Nicotinate phosphoribosyltransferase FEE38_05380 ENOG4105CH2 amidohydrolase FEE38_05385 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FEE38_05390 ENOG4105C44 Serine transporter FEE38_05395 ENOG4107RCH Diaminopropionate ammonia-lyase FEE38_05405 ENOG4105C5S asparaginyl-tRNA synthetase FEE38_05410 ENOG4105ZIT Porin Gram-negative type FEE38_05415 ENOG4105CGF Aromatic amino acid aminotransferase FEE38_05420 ENOG4105C5X domain protein FEE38_05425 ENOG4105EAQ (twin-arginine translocation) pathway signal FEE38_05430 ENOG4105DIT ErfK YbiS YcfS YnhG family protein FEE38_05435 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) FEE38_05440 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) FEE38_05445 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) FEE38_05450 ENOG4106371 Methyltransferase FEE38_05455 ENOG4107S90 membrAne FEE38_05460 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups FEE38_05465 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FEE38_05470 ENOG4105W49 UPF0434 protein FEE38_05475 ENOG4105T0Z Conserved Protein FEE38_05480 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FEE38_05485 ENOG4105BZ1 (ABC) transporter FEE38_05490 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 FEE38_05495 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FEE38_05500 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FEE38_05505 ENOG4105CAT Cytidine monophosphate kinase FEE38_05510 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FEE38_05515 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FEE38_05520 ENOG4107VMU Membrane FEE38_05525 ENOG4105DDY UPF0142 protein ycaO FEE38_05530 ENOG4105TMB Formate nitrite transporter FEE38_05535 ENOG4105C6N Formate acetyltransferase FEE38_05540 ENOG4105F1A Pyruvate formate-lyase FEE38_05545 ENOG4108ISG Major Facilitator FEE38_05555 ENOG4107KGK dmso reductase anchor subunit FEE38_05560 ENOG4105QAX Iron-sulfur FEE38_05565 ENOG4107QY8 reductase FEE38_05570 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FEE38_05575 ENOG4105D1H recombination factor protein RarA FEE38_05580 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FEE38_05585 ENOG4105CNU cell division protein FtsK FEE38_05590 ENOG4105EW9 transcriptional regulator AsnC family FEE38_05595 ENOG4105C3M thioredoxin reductase FEE38_05600 ENOG4108JJ9 ABC, transporter FEE38_05605 ENOG4108JJ8 (ABC) transporter FEE38_05610 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FEE38_05615 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FEE38_05620 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FEE38_05625 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FEE38_05630 ENOG4105VEQ Cold shock protein FEE38_05640 ENOG4105DJY efflux transporter, rnd family, mfp subunit FEE38_05645 ENOG4105CPB ATP-dependent endonuclease of the OLD family FEE38_05650 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FEE38_05655 ENOG4105DWU Membrane FEE38_05665 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FEE38_05675 ENOG4105C7K acetolactate synthase FEE38_05680 ENOG4105C5W Aldolase FEE38_05685 ENOG4105CGD Nad-dependent epimerase dehydratase FEE38_05690 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FEE38_05695 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FEE38_05705 ENOG41064MM (LipO)protein FEE38_05710 ENOG4105E5Z arginine transporter ATP-binding subunit FEE38_05715 ENOG4106PMH Extracellular solute-binding protein family 3 FEE38_05720 ENOG4105GBT ABC transporter FEE38_05725 ENOG4105DMR ABC, transporter FEE38_05730 ENOG4106TNF Periplasmic binding protein FEE38_05735 ENOG4105BZU Histidine kinase FEE38_05740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FEE38_05745 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) FEE38_05750 ENOG4105RBQ inner membrane protein ybjO FEE38_05755 ENOG4105D38 putrescine abc transporter FEE38_05760 ENOG4105F38 ABC transporter, permease FEE38_05765 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FEE38_05770 ENOG4107RUE extracellular solute-binding protein family 1 FEE38_05775 ENOG4108RMJ sensory transduction regulator FEE38_05785 ENOG4108DBC nitroreductase FEE38_05790 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress FEE38_05795 ENOG41090BQ Glutaredoxin FEE38_05800 ENOG4105GWF inner membrane protein YbjM FEE38_05805 ENOG4105D0C transport protein FEE38_05810 ENOG4108RFG Tetr family transcriptional regulator FEE38_05815 ENOG4106UW1 Major Facilitator superfamily FEE38_05820 ENOG4108HCJ Hydrolase FEE38_05825 ENOG4107QF7 multi-drug FEE38_05835 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FEE38_05840 ENOG4107FB0 transcriptional regulator DeoR family FEE38_05845 ENOG4105DZ1 carboxypeptidase FEE38_05855 ENOG4108TGY Glutathione S-transferase FEE38_05860 ENOG4105D8V Glucose sorbosone dehydrogenase FEE38_05865 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway FEE38_05870 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FEE38_05875 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FEE38_05880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FEE38_05885 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FEE38_05890 ENOG4105DEF Extracellular solute-binding protein, family 5 FEE38_05895 ENOG4108JQ6 ABC transporter FEE38_05900 ENOG4105D44 asparaginase FEE38_05905 ENOG4105CVM Molybdenum cofactor synthesis domain protein FEE38_05910 ENOG4105D06 uba thif-type nad fad binding protein FEE38_05915 ENOG4105F1A Pyruvate formate-lyase FEE38_05925 ENOG4108HCJ Hydrolase FEE38_05930 ENOG41072TH Protein of unknown function (DUF1479) FEE38_05935 ENOG4105ETE Transcriptional regulator (LacI family FEE38_05950 ENOG4105C5H ABC transporter FEE38_05955 ENOG4105M2Z protein tyrosine serine phosphatase FEE38_05960 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FEE38_05965 ENOG4108TZY GntR Family Transcriptional Regulator FEE38_05970 ENOG4105CS2 ec 3.2.1.21 FEE38_05975 ENOG4105F4P )-transporter FEE38_05980 ENOG4105KST dependent repressor FEE38_05990 ENOG4108I6E Sulfatase FEE38_05995 ENOG4108T1M outer membrane protein x FEE38_06005 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction FEE38_06010 ENOG4107R0W ABC transporter FEE38_06015 ENOG4105E5Q amino acid AbC transporter FEE38_06020 ENOG4105CDA abc transporter atp-binding protein FEE38_06025 ENOG4105D8X mechanosensitive ion channel FEE38_06030 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) FEE38_06035 ENOG4105EW6 flavin reductase domain protein, FMN-binding FEE38_06045 ENOG4105KSC Transcriptional regulator, TraR DksA family FEE38_06050 ENOG4105VR4 UPF0379 protein ybiJ FEE38_06055 ENOG4108MTB glycosyl transferase family FEE38_06060 ENOG4105DVT helicase FEE38_06065 ENOG4105C1J atp-dependent rna helicase FEE38_06085 ENOG4105DJB Major Facilitator Superfamily FEE38_06090 ENOG4108PZW LysR family Transcriptional regulator FEE38_06095 ENOG4107MVR Transcriptional regulator FEE38_06100 ENOG4105D0S secretion protein (HlyD FEE38_06105 ENOG4105CJ1 ABC, transporter FEE38_06110 ENOG4107QWP ABC-2 type transporter FEE38_06115 ENOG4107QWP ABC-2 type transporter FEE38_06120 ENOG4105I9U inner membrane protein ybhQ FEE38_06125 ENOG4105X23 Endonuclease Exonuclease phosphatase FEE38_06130 ENOG4105DZQ phospholipase D Transphosphatidylase FEE38_06135 ENOG4107UXM Membrane FEE38_06145 ENOG4105HFZ Membrane FEE38_06150 ENOG4108ZAF Molybdopterin FEE38_06155 ENOG4105M00 molybdopterin converting factor, subunit 1 FEE38_06160 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FEE38_06165 ENOG4108RIR Molybdenum cofactor biosynthesis protein FEE38_06170 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FEE38_06180 ENOG4105CHW UPF0052 protein FEE38_06185 ENOG4105DIJ Phosphoethanolamine transferase FEE38_06190 ENOG4105XJC Two component transcriptional regulator (Winged helix family FEE38_06195 ENOG4105ECM Sensor protein basS pmrB FEE38_06205 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FEE38_06220 ENOG4108IV0 ABC, transporter FEE38_06230 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FEE38_06235 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FEE38_06240 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FEE38_06245 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FEE38_06250 ENOG4108V1U phospholipid-binding protein FEE38_06255 ENOG4105C85 amino acid FEE38_06260 ENOG4105C84 Histidine ammonia-lyase FEE38_06265 ENOG4105CGP Urocanate hydratase FEE38_06275 ENOG41088SP formiminoglutamate hydrolase FEE38_06280 ENOG4105CI2 imidazolone-5-propionate hydrolase FEE38_06285 ENOG4105NBR Pectinesterase FEE38_06290 ENOG4108SER Transposase FEE38_06300 ENOG4108U51 Universal stress protein FEE38_06305 ENOG4105ENT Efflux transporter rnd family, mfp subunit FEE38_06335 ENOG4108XDN Transcriptional regulator FEE38_06340 ENOG4105BZU Histidine kinase FEE38_06345 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component FEE38_06360 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FEE38_06365 ENOG4108K4B hydrolase FEE38_06375 ENOG4105E0C molybdate abc transporter FEE38_06380 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FEE38_06390 ENOG4105F4R Transcriptional regulator mode FEE38_06395 ENOG4105DKW ABC transporter FEE38_06400 ENOG4105CMR udp-glucose 4-epimerase FEE38_06405 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FEE38_06410 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FEE38_06415 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FEE38_06420 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FEE38_06425 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FEE38_06430 ENOG4105JND homeobox protein FEE38_06435 ENOG4105PGM cation diffusion facilitator family transporter FEE38_06440 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FEE38_06445 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FEE38_06490 ENOG4105UFD tol-pal system protein YbgF FEE38_06495 ENOG4105KCK Peptidoglycan-associated lipoprotein FEE38_06505 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA FEE38_06515 ENOG4105E02 MotA TolQ exbB proton channel FEE38_06520 ENOG4107YD3 Thioesterase FEE38_06525 ENOG4105KJB cyd operon protein YbgE FEE38_06535 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FEE38_06540 ENOG4105C4M (Ubiquinol oxidase) subunit I FEE38_06545 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FEE38_06550 ENOG4105CMV Succinyl-CoA synthetase subunit beta FEE38_06555 ENOG4105C7S Dehydrogenase FEE38_06560 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FEE38_06565 ENOG4105E33 succinate dehydrogenase FEE38_06570 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FEE38_06575 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FEE38_06580 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FEE38_06585 ENOG4105BZN citrate synthase FEE38_06590 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) FEE38_06610 ENOG4105E7W lamb ycsf family protein FEE38_06615 ENOG4107R7A Allophanate hydrolase subunit 2 FEE38_06620 ENOG4105P4J Allophanate hydrolase, subunit 1 FEE38_06625 ENOG4107QNR UPF0135 protein FEE38_06630 ENOG4105DUX Transporter FEE38_06635 ENOG4105CVP deoxyribo-dipyrimidine photolyase FEE38_06640 ENOG4105XIQ Protein of unknown function (DUF2517) FEE38_06650 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FEE38_06655 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FEE38_06660 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FEE38_06665 ENOG4105C08 Histidine kinase FEE38_06670 ENOG4105EEX Two component transcriptional regulator (Winged helix family FEE38_06680 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 FEE38_06685 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) FEE38_06690 ENOG4105EV9 Alpha Beta Hydrolase FEE38_06695 ENOG4105NNH LexA regulated protein FEE38_06700 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) FEE38_06705 ENOG41090R7 Ferric uptake FEE38_06710 ENOG4105CSH Transporter FEE38_06715 ENOG4105GX6 (LipO)protein FEE38_06720 ENOG4105J5J Outer membrane porin FEE38_06730 ENOG4105CX6 glutaminyL-tRNA synthetase FEE38_06735 ENOG4105CI1 PTS System FEE38_06740 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FEE38_06745 ENOG4105CE4 GlcNAc 6-P deacetylase FEE38_06750 ENOG4105E2R ROK family FEE38_06755 ENOG4105D4U had-superfamily hydrolase, subfamily iia FEE38_06760 ENOG4105CAQ asparagine synthetase FEE38_06805 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FEE38_06810 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FEE38_06815 ENOG4105C9A Phoh family FEE38_06820 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FEE38_06825 ENOG4108JU5 Magnesium and cobalt efflux protein FEE38_06830 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FEE38_06835 ENOG4107RP9 extracellular solute-binding protein, family 3 FEE38_06840 ENOG4105EAD ABC transporter FEE38_06845 ENOG4105DRP amino acid AbC transporter FEE38_06850 ENOG4105CDA abc transporter atp-binding protein FEE38_06865 ENOG4107PAI alpha helical protein FEE38_06870 ENOG4105C8T Leucyl-tRNA synthetase FEE38_06880 ENOG4105DJF DNA polymerase III, delta' subunit FEE38_06885 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FEE38_06890 ENOG4108TGR phosphatase FEE38_06895 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FEE38_06900 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FEE38_06905 ENOG4105CJN penicillin-binding protein FEE38_06910 ENOG4105CNI cell division protein FtsW FEE38_06915 ENOG4105K6T rare lipoprotein A FEE38_06920 ENOG4105DZ1 carboxypeptidase FEE38_06925 ENOG4108Z43 UPF0250 protein FEE38_06930 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FEE38_06935 ENOG41064T2 transcriptional regulator, lysR family FEE38_06940 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FEE38_06945 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) FEE38_06965 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) FEE38_06970 ENOG4105CEE C4-dicarboxylate transporter FEE38_06975 ENOG4105KTS ribonuclease FEE38_06980 ENOG4105NXH GreA GreB family elongation factor FEE38_06985 ENOG4108U51 Universal stress protein FEE38_06990 ENOG4108JU3 Alkyl hydroperoxide reductase FEE38_06995 ENOG4105D3R alkyl hydroperoxide reductase FEE38_07000 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase FEE38_07005 ENOG4105DQS Transcriptional regulator FEE38_07010 ENOG4105BZV Phosphoadenosine phosphosulfate reductase FEE38_07015 ENOG4105GTN ParB Domain Protein Nuclease FEE38_07020 ENOG4105CHM Aminotransferase FEE38_07025 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) FEE38_07030 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FEE38_07045 ENOG4105C2J ABC transporter FEE38_07055 ENOG4105CNN ABC, transporter FEE38_07065 ENOG4108M3J Dehydrogenase FEE38_07075 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FEE38_07080 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin FEE38_07090 ENOG4105DZC cytosine deaminase FEE38_07095 ENOG4105ETE Transcriptional regulator (LacI family FEE38_07100 ENOG4105ECY inositol monophosphatase FEE38_07105 ENOG4105CXY transporter FEE38_07110 ENOG4105D6F Phosphatase FEE38_07115 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FEE38_07120 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FEE38_07140 ENOG4105CNN ABC, transporter FEE38_07145 ENOG4105C2J ABC transporter FEE38_07150 ENOG4107SCQ Iron-containing alcohol dehydrogenase FEE38_07155 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FEE38_07170 ENOG4105VCD cytoplasmic protein FEE38_07175 ENOG4105D22 carbon starvation protein FEE38_07180 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) FEE38_07185 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FEE38_07190 ENOG4105WQI isochorismatase FEE38_07195 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FEE38_07200 ENOG4105E4F Isochorismate synthase FEE38_07205 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein FEE38_07210 ENOG4105E8G Major facilitator Superfamily FEE38_07215 ENOG4105DQ5 transport system permease protein FEE38_07220 ENOG4105TVJ transport system, permease FEE38_07225 ENOG4105E0A ABC, transporter FEE38_07230 ENOG4105C0W non-ribosomal peptide synthetase FEE38_07235 ENOG41085A6 mbth domain-containing protein FEE38_07240 ENOG4105E93 esterase FEE38_07245 ENOG4107RNH Outer membrane receptor FepA FEE38_07250 ENOG4108TSE Transferase FEE38_07255 ENOG4108IUS Transketolase FEE38_07260 ENOG4108HHA Transketolase FEE38_07265 ENOG4105DKT Transcriptional regulator FEE38_07270 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FEE38_07275 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FEE38_07285 ENOG4105C2J ABC transporter FEE38_07290 ENOG4105CNN ABC, transporter FEE38_07310 ENOG410810E transcriptional regulator, lysR family FEE38_07315 ENOG4105CUY Mechanosensitive ion channel FEE38_07320 ENOG4108WN0 inhibitor of vertebrate lysozyme FEE38_07325 ENOG4105C94 Transporter FEE38_07340 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FEE38_07350 ENOG4105DEF Extracellular solute-binding protein, family 5 FEE38_07355 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FEE38_07360 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FEE38_07365 ENOG4105C3U ABC transporter FEE38_07370 ENOG4108JQ7 (ABC) transporter FEE38_07380 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FEE38_07385 ENOG4105EMU Dehydrogenase FEE38_07395 ENOG4105GBT ABC transporter FEE38_07400 ENOG4105E5Q amino acid AbC transporter FEE38_07405 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FEE38_07415 ENOG4105CHM Aminotransferase FEE38_07420 ENOG4105T38 integral membrane protein FEE38_07425 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FEE38_07440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FEE38_07450 ENOG4108J59 Extracellular solute-binding protein, family 5 FEE38_07455 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) FEE38_07460 ENOG4108T58 Mg2 transport protein CorA FEE38_07485 ENOG4105WQ6 Membrane FEE38_07490 ENOG4105HFT AraC family transcriptional regulator FEE38_07500 ENOG410630P Transcriptional regulator FEE38_07505 ENOG4105MSB protein, conserved in bacteria FEE38_07510 ENOG4108RCM Nitroreductase FEE38_07540 ENOG4105CUY Mechanosensitive ion channel FEE38_07545 ENOG4105ETE Transcriptional regulator (LacI family FEE38_07555 ENOG4105CK5 oxidoreductase FEE38_07565 ENOG4105EAA nucleoside FEE38_07570 ENOG4105C85 amino acid FEE38_07580 ENOG4108NS2 receptor FEE38_07585 ENOG4105C26 Dehydrogenase FEE38_07590 ENOG4105CJP fad dependent oxidoreductase FEE38_07600 ENOG4105CUB amino acid FEE38_07610 ENOG4105DGU Histone deacetylase FEE38_07620 ENOG4108UAJ Transcriptional regulator FEE38_07630 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FEE38_07645 ENOG4105CPC Aldo Keto reductase FEE38_07650 ENOG4105E89 ABC transporter FEE38_07655 ENOG4105CH2 amidohydrolase FEE38_07675 ENOG4105EHG Permease protein FEE38_07680 ENOG4105E0A ABC, transporter FEE38_07685 ENOG4105EFX secretion protein, HlyD family FEE38_07690 ENOG4105KK7 inner membrane protein YiaW FEE38_07700 ENOG4105D7K pfkb domain protein FEE38_07705 ENOG4108M0B Sucrose porin FEE38_07710 ENOG4105C5Y PTS System FEE38_07715 ENOG4108HKT sucrose-6-phosphate hydrolase FEE38_07720 ENOG4105WBN Transcriptional regulator (LacI family FEE38_07730 ENOG4108HWV )-transporter FEE38_07735 ENOG4105C2J ABC transporter FEE38_07775 ENOG4105CRK lysyL-tRNA synthetase FEE38_07780 ENOG4105DUX Transporter FEE38_07785 ENOG4105CXN decarboxylase FEE38_07790 ENOG4105D5Q Arginine ornithine antiporter FEE38_07795 ENOG4108M3R transcriptional activator CadC FEE38_07810 ENOG4105D1S lipid A biosynthesis FEE38_07825 ENOG4105CW0 outer membrane usher protein FEE38_07830 ENOG4105GQR Chaperone FEE38_07835 ENOG4105X0I Fimbrial FEE38_07850 ENOG4105BZN citrate synthase FEE38_07990 ENOG4108TFU terminase (Small subunit) FEE38_08055 ENOG4108R1E Serine threonine protein phosphatase 1 FEE38_08060 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 FEE38_08065 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi FEE38_08225 ENOG4108KU3 Integrase FEE38_08240 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FEE38_08245 ENOG4105WQ3 Rna-binding protein FEE38_08250 ENOG4105C8N cysteinyl-tRNA synthetase FEE38_08255 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FEE38_08260 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) FEE38_08270 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FEE38_08275 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FEE38_08290 ENOG4105CV6 ABC transporter, permease FEE38_08300 ENOG4108UJV acyl-CoA thioesterase i FEE38_08305 ENOG4105E1F short-chain dehydrogenase reductase FEE38_08310 ENOG4107QR8 Thioredoxin FEE38_08320 ENOG4105C4B ABC transporter, permease FEE38_08325 ENOG41083J0 (ABC) transporter FEE38_08330 ENOG4107QX8 SPFH domain, Band 7 family protein FEE38_08335 ENOG4105G5H Membrane FEE38_08340 ENOG4108Z6Z Transcriptional regulator FEE38_08345 ENOG4105C59 p-type ATPase FEE38_08350 ENOG4105MBR gumn family FEE38_08355 ENOG4108Z66 YbaK ebsC protein FEE38_08360 ENOG4105CGH 5'-nucleotidase FEE38_08365 ENOG4105EU0 Major facilitator Superfamily FEE38_08370 ENOG4105CKD glutathione-regulated potassium-efflux system protein FEE38_08375 ENOG4107RE1 Inosine-guanosine kinase FEE38_08385 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FEE38_08390 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FEE38_08395 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FEE38_08400 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FEE38_08405 ENOG4107QMP dna polymerase iii subunits gamma and tau FEE38_08410 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FEE38_08415 ENOG4105WD1 Membrane FEE38_08420 ENOG4108URS primosomal replication protein n'' FEE38_08425 ENOG4106428 Protein of unknown function (DUF2496) FEE38_08430 ENOG4105DNE Transposase FEE38_08435 ENOG4105EGS Mechanosensitive ion channel FEE38_08440 ENOG4107XI7 Tetr family transcriptional regulator FEE38_08445 ENOG4105C1P efflux transporter, rnd family, mfp subunit FEE38_08450 ENOG4105BZS acriflavin resistance protein FEE38_08455 ENOG4108UKR Biofilm formation regulator YbaJ FEE38_08465 ENOG4108UW5 maltose o-acetyltransferase FEE38_08470 ENOG4105GSJ Inner membrane protein ylaC FEE38_08485 ENOG4105YK5 50S ribosomal protein L36 FEE38_08495 ENOG4105ETE Transcriptional regulator (LacI family FEE38_08500 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FEE38_08505 ENOG4105CI1 PTS System FEE38_08510 ENOG4105C4C beta-galactosidase FEE38_08520 ENOG4105EG2 ABC transporter, permease FEE38_08530 ENOG4107FKK extracellular solute-binding protein family 1 FEE38_08540 ENOG41066DG (EAL) domain protein FEE38_08545 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter FEE38_08550 ENOG41061MD high-affinity nickel-transporter FEE38_08555 ENOG4108VW9 Membrane FEE38_08585 ENOG41080UX Methyltransferase FEE38_08590 ENOG4108MNP Glycoprotein polysaccharide metabolism FEE38_08595 ENOG4105C29 acyl-CoA thioesterase FEE38_08600 ENOG4105BZU Histidine kinase FEE38_08605 ENOG4108YZA Nitrogen regulatory protein pii FEE38_08610 ENOG4105BZ1 (ABC) transporter FEE38_08615 ENOG4105BZ1 (ABC) transporter FEE38_08620 ENOG4108XM1 transcriptional regulator AsnC family FEE38_08630 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) FEE38_08635 ENOG4108NFA extracellular solute-binding protein FEE38_08640 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FEE38_08645 ENOG4108TGP Thioesterase superfamily protein FEE38_08650 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FEE38_08655 ENOG4105EIN peptidylprolyl cis-trans isomerase FEE38_08660 ENOG4105K70 DNA-binding protein FEE38_08665 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FEE38_08670 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FEE38_08680 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FEE38_08695 ENOG4105M85 Bola protein FEE38_08700 ENOG4105IEY (LipO)protein FEE38_08705 ENOG4105EYM Major Facilitator superfamily FEE38_08710 ENOG4105E2S oxidase) subunit II FEE38_08715 ENOG4105BZ9 Cytochrome C oxidase, subunit I FEE38_08720 ENOG4105CCU oxidase (Subunit III) FEE38_08725 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FEE38_08730 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FEE38_08740 ENOG4107HP6 Transcriptional regulator FEE38_08745 ENOG4105E2X shikimate dehydrogenase FEE38_08750 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein FEE38_08760 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein FEE38_08770 ENOG4105D2S major facilitator superfamily FEE38_08775 ENOG4105CIB oxidoreductase Domain protein FEE38_08780 ENOG4107RDB Major Facilitator FEE38_08790 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FEE38_08795 ENOG4107S0N DJ-1 family FEE38_08805 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FEE38_08810 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FEE38_08815 ENOG4105CTB Polyprenyl synthetase FEE38_08820 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FEE38_08825 ENOG4105CPC Aldo Keto reductase FEE38_08830 ENOG4108ZAI phosphatidylglycerophosphatase a FEE38_08835 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FEE38_08840 ENOG4107YIM Involved in the transcription termination process (By similarity) FEE38_08845 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FEE38_08850 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FEE38_08855 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FEE38_08860 ENOG4108KIC (LipO)protein FEE38_08865 ENOG4105DRB nucleoside-specific channel-forming protein FEE38_08880 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FEE38_08885 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FEE38_08890 ENOG4105VIE preprotein translocase, subunit YajC FEE38_08895 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FEE38_08900 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FEE38_08905 ENOG4108ZYK Acyl carrier protein phosphodiesterase FEE38_08910 ENOG4105D3R alkyl hydroperoxide reductase FEE38_08915 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FEE38_08930 ENOG4108MGF sugar kinase FEE38_08940 ENOG4105CI2 imidazolone-5-propionate hydrolase FEE38_08950 ENOG4105CHJ isochorismatase hydrolase FEE38_08955 ENOG4105EQ1 Transcriptional regulator FEE38_08960 ENOG4107R28 alpha amylase, catalytic region FEE38_08965 ENOG4105C85 amino acid FEE38_08970 ENOG4105CWM branched-chain amino acid transport system II carrier protein FEE38_08975 ENOG4105BZU Histidine kinase FEE38_08980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FEE38_08985 ENOG4107RH8 nuclease SbcCD subunit D FEE38_08990 ENOG4105EYH Exonuclease FEE38_08995 ENOG4105DKQ ROK family FEE38_09000 ENOG4105DH7 May be involved in recombination (By similarity) FEE38_09005 ENOG4105NBK UPF0345 protein FEE38_09010 ENOG4105HBA AroM protein FEE38_09015 ENOG4105SS3 FEE38_09020 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FEE38_09025 ENOG4105G4C Periplasmic ligand-binding sensor protein FEE38_09030 ENOG4108UPT UPF0178 protein FEE38_09035 ENOG4105II7 pyrroline-5-carboxylate reductase FEE38_09040 ENOG4105VIF phosphate starvation-inducible protein FEE38_09045 ENOG4105G6Z alkaline phosphatase FEE38_09065 ENOG4105CPF Cell wall formation (By similarity) FEE38_09070 ENOG4105UNH Membrane FEE38_09075 ENOG4105FR5 inner membrane protein YaiY FEE38_09080 ENOG4107QS8 (LipO)protein FEE38_09090 ENOG4108RWI nicotinamidase FEE38_09095 ENOG4107R6D beta-lactam binding protein AmpH FEE38_09100 ENOG4105D52 delta-aminolevulinic acid dehydratase FEE38_09110 ENOG4105E2B Taurine dioxygenase FEE38_09115 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FEE38_09120 ENOG4108ETV ABC transporter FEE38_09125 ENOG4106FTQ Taurine ABC transporter, periplasmic FEE38_09130 ENOG4107QK5 Homocysteine s-methyltransferase FEE38_09135 ENOG4108IQI permease FEE38_09140 ENOG4105C85 amino acid FEE38_09145 ENOG4105CPD ethanolamine ammonia-lyase FEE38_09150 ENOG4107FQ9 ethanolamine ammonia-lyase FEE38_09160 ENOG4105C32 Amino acid ABC transporter (Permease) FEE38_09165 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FEE38_09170 ENOG4105C0Z ABC transporter FEE38_09175 ENOG4108IV0 ABC, transporter FEE38_09190 ENOG4105CT1 (ABC) transporter FEE38_09195 ENOG4105CDA abc transporter atp-binding protein FEE38_09200 ENOG4105EZ7 amino acid ABC transporter FEE38_09205 ENOG4105DRP amino acid AbC transporter FEE38_09215 ENOG4106PYX Receptor FEE38_09220 ENOG4108N3D putative enzyme FEE38_09225 ENOG4108NN8 Fimbrial protein FEE38_09230 ENOG4108GWT fimbrillin MatB FEE38_09235 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon FEE38_09250 ENOG4105EHI Phosphonate ABC transporter, periplasmic FEE38_09260 ENOG4105S7S phosphonate abc transporter FEE38_09290 ENOG4108QBX (LipO)protein FEE38_09295 ENOG4105FCK Membrane FEE38_09300 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FEE38_09315 ENOG4105DFP Integrase FEE38_09390 ENOG4107R0V Pyruvate dehydrogenase FEE38_09395 ENOG4105CPP Dehydrogenase, E1 component FEE38_09405 ENOG4107QN2 dihydrolipoyl dehydrogenase FEE38_09420 ENOG41061GT Aldolase FEE38_09430 ENOG4105CMG Carbohydrate kinase FEE38_09435 ENOG4105CHR reductase FEE38_09440 ENOG4108JQ1 Dehydrogenase FEE38_09445 ENOG4105DT3 PTS system, galactitol-specific IIc component FEE38_09450 ENOG4108TGY Glutathione S-transferase FEE38_09455 ENOG4105DTA methyltransferase FEE38_09460 ENOG4105YCT UPF0386 protein FEE38_09470 ENOG4105D5U fad dependent oxidoreductase FEE38_09475 ENOG4105C26 Dehydrogenase FEE38_09480 ENOG4108JPW Aminotransferase FEE38_09485 ENOG4105C85 amino acid FEE38_09490 ENOG4108PVQ transcriptional regulator FEE38_09495 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) FEE38_09500 ENOG4105V1F Fermentation respiration switch protein FEE38_09505 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) FEE38_09510 ENOG4105CIN aminoacyl-histidine dipeptidase FEE38_09515 ENOG4108HYG acetyltransferase FEE38_09520 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FEE38_09535 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) FEE38_09540 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FEE38_09545 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FEE38_09550 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FEE38_09555 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FEE38_09560 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FEE38_09565 ENOG4105F7V ErfK ybiS ycfS ynhG family protein FEE38_09570 ENOG4105E7A Glutamine amidotransferase FEE38_09575 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FEE38_09580 ENOG4107QPN acyl-Coa dehydrogenase FEE38_09585 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FEE38_09590 ENOG4108VP3 Lysine exporter protein (LysE YggA) FEE38_09595 ENOG41090KR LysR family transcriptional Regulator FEE38_09605 ENOG4107RZZ dna polymerase iii epsilon subunit FEE38_09610 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FEE38_09615 ENOG4105D1A Methyltransferase FEE38_09620 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FEE38_09625 ENOG4105E9H Lytic Murein transglycosylase FEE38_09630 ENOG4105F2W methyltransferase FEE38_09640 ENOG4105F27 Major Facilitator FEE38_09645 ENOG4105HEI LysR family (Transcriptional regulator FEE38_09650 ENOG4105CV8 reductase FEE38_09685 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FEE38_09690 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FEE38_09695 ENOG4108UMI ABC transporter, permease FEE38_09700 ENOG4105D01 (LipO)protein FEE38_09705 ENOG4108R8X outer membrane lipoprotein FEE38_09710 ENOG4108R96 Methyltransferase, YaeB family FEE38_09715 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FEE38_09720 ENOG4108UY0 (LipO)protein FEE38_09725 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion FEE38_09730 ENOG4108YZN class I peptide chain release factor FEE38_09735 ENOG4108VWS Yaeq family FEE38_09740 ENOG4105W1I UPF0253 protein FEE38_09745 ENOG4105M1T rho-binding antiterminator FEE38_09750 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FEE38_09755 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FEE38_09760 ENOG4105CXN decarboxylase FEE38_09765 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FEE38_09770 ENOG4105C0B DNA polymerase III (alpha subunit) FEE38_09775 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FEE38_09780 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FEE38_09785 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FEE38_09790 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FEE38_09795 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FEE38_09800 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FEE38_09805 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FEE38_09810 ENOG4105DZP Membrane-associated zinc metalloprotease FEE38_09815 ENOG4105KNE Phosphatidate cytidylyltransferase FEE38_09830 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FEE38_09840 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FEE38_09845 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FEE38_09850 ENOG4105CE9 30S ribosomal protein S2 FEE38_09855 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FEE38_09860 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FEE38_09865 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FEE38_09870 ENOG4108T8E UPF0325 protein FEE38_09875 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FEE38_09880 ENOG4105C0H protease FEE38_09885 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FEE38_09890 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FEE38_09895 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FEE38_09900 ENOG4105EN6 Membrane FEE38_09905 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FEE38_09910 ENOG4105CMQ Chloride channel FEE38_09915 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FEE38_09920 ENOG4105S6R Iron-hydroxamate transporter permease subunit FEE38_09925 ENOG4105J76 Periplasmic binding protein FEE38_09930 ENOG4105E0A ABC, transporter FEE38_09935 ENOG4105E0K tonB-dependent siderophore receptor FEE38_09940 ENOG4105BZ4 penicillin-binding protein FEE38_10025 ENOG4105CQ7 ATP-dependent helicase FEE38_10030 ENOG4107XID 2'-5' rna ligase FEE38_10035 ENOG4105PW4 Sugar fermentation stimulation protein homolog FEE38_10040 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FEE38_10045 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FEE38_10050 ENOG4105DJ0 Poly(A) Polymerase FEE38_10055 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FEE38_10060 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FEE38_10065 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FEE38_10070 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FEE38_10075 ENOG4107BJW polysaccharide deacetylase FEE38_10080 ENOG4108YTN IIa component FEE38_10085 ENOG4105E3A (ABC) transporter FEE38_10090 ENOG4105DA5 (ABC) transporter FEE38_10095 ENOG41077A9 carbonic anhydrase FEE38_10100 ENOG4108UGV hypoxanthine phosphoribosyltransferase FEE38_10105 ENOG4105DZG Dehydrogenase FEE38_10110 ENOG4105E3B Multicopper oxidase FEE38_10115 ENOG4108ZRK uncharacterized protein yacC FEE38_10130 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FEE38_10135 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FEE38_10140 ENOG4108ZIG UPF0231 protein FEE38_10145 ENOG4107QIJ Aconitate hydratase 2 FEE38_10155 ENOG4108NST exported protein FEE38_10170 ENOG4107QN2 dihydrolipoyl dehydrogenase FEE38_10175 ENOG4107QSN dihydrolipoamide acetyltransferase FEE38_10180 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FEE38_10185 ENOG41073TP transcriptional regulator FEE38_10190 ENOG4105C85 amino acid FEE38_10195 ENOG4105CT4 transporter FEE38_10200 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) FEE38_10205 ENOG4106A72 regulatory protein AmpE FEE38_10210 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FEE38_10215 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FEE38_10220 ENOG4108ZUW Major pilin subunit FEE38_10225 ENOG4107QHF type ii secretion system protein e FEE38_10230 ENOG4105D7Q type ii secretion system FEE38_10235 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FEE38_10240 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FEE38_10245 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) FEE38_10250 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) FEE38_10255 ENOG4105M6F mutator MutT protein FEE38_10260 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FEE38_10265 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) FEE38_10270 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FEE38_10275 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FEE38_10280 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FEE38_10285 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FEE38_10295 ENOG4105DFU Cell wall formation (By similarity) FEE38_10300 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FEE38_10305 ENOG4105CNI cell division protein FtsW FEE38_10315 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FEE38_10320 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FEE38_10325 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FEE38_10330 ENOG4105CJN penicillin-binding protein FEE38_10335 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FEE38_10340 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FEE38_10350 ENOG4107B7Y DNA-binding transcriptional regulator FruR FEE38_10355 ENOG4108ZP8 Acetolactate synthase small subunit FEE38_10360 ENOG4105C7K acetolactate synthase FEE38_10370 ENOG41064T2 transcriptional regulator, lysR family FEE38_10380 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FEE38_10390 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FEE38_10395 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FEE38_10410 ENOG4105EMV Major Facilitator FEE38_10415 ENOG4105FF2 Type I DHQase FEE38_10420 ENOG4105C5Q Transcriptional regulator FEE38_10425 ENOG4105DJB Major Facilitator Superfamily FEE38_10430 ENOG4105S8Q sugar efflux transporter FEE38_10450 ENOG4106SMU thiamine transporter membrane protein FEE38_10460 ENOG4108KF1 Membrane FEE38_10465 ENOG41063TF transcriptional regulator (AraC FEE38_10470 ENOG4105EF1 ribulokinase FEE38_10475 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FEE38_10480 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FEE38_10485 ENOG4105CQ2 DNA polymerase FEE38_10490 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FEE38_10495 ENOG4105D3G Pseudouridine synthase FEE38_10505 ENOG4105D2K citrate carrier protein FEE38_10510 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FEE38_10515 ENOG4106YYS transcriptional regulatory protein FEE38_10520 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) FEE38_10525 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FEE38_10535 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FEE38_10540 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FEE38_10550 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FEE38_10555 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FEE38_10560 ENOG4105CKD glutathione-regulated potassium-efflux system protein FEE38_10570 ENOG4105M5B (LipO)protein FEE38_10575 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FEE38_10580 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FEE38_10585 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FEE38_10590 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FEE38_10595 ENOG4105EXG Transcriptional regulator FEE38_10605 ENOG4105DU0 nucleoside hydrolase FEE38_10610 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FEE38_10615 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FEE38_10620 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FEE38_10630 ENOG4105DTN riboflavin biosynthesis protein ribF FEE38_10645 ENOG41063Z6 transcriptional regulator, lysR family FEE38_10650 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FEE38_10655 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FEE38_10660 ENOG4105CFG Acts as a chaperone (By similarity) FEE38_10665 ENOG4108WTA UPF0412 protein YaaI FEE38_10670 ENOG4108QUJ UPF0174 protein YaaW FEE38_10675 ENOG4106HK8 GPR1 FUN34 yaaH family protein FEE38_10680 ENOG4105CSH Transporter FEE38_10685 ENOG4108RIR Molybdenum cofactor biosynthesis protein FEE38_10690 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FEE38_10700 ENOG4105D1Q UPF0246 protein FEE38_10710 ENOG4105D98 threonine synthase FEE38_10715 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FEE38_10720 ENOG4105CFH Aspartokinase FEE38_10730 ENOG4106FVC RNA methyltransferase FEE38_10735 ENOG410759A FEE38_10740 ENOG41065U4 response regulator FEE38_10745 ENOG4105CT7 inner membrane cred family protein FEE38_10750 ENOG4105EB3 Histidine kinase FEE38_10755 ENOG4105E3W Two component transcriptional regulator (Winged helix family FEE38_10760 ENOG4108RH0 Crea protein FEE38_10765 ENOG4105UEI Transcriptional Regulator AraC Family FEE38_10770 ENOG4105CVJ phosphoglycerate mutase FEE38_10775 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FEE38_10780 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) FEE38_10785 ENOG4107SC1 transglycosylase FEE38_10790 ENOG4105C5H ABC transporter FEE38_10795 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase FEE38_10800 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FEE38_10805 ENOG4105EAC phosphoserine phosphatase FEE38_10810 ENOG41062Z9 Membrane FEE38_10815 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) FEE38_10830 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FEE38_10840 ENOG4105D9N nucleoside FEE38_10845 ENOG4105EYA deoxyribonuclease FEE38_10850 ENOG4108NRW Phospholipase, patatin family FEE38_10855 ENOG41075IC Protein of unknown function (DUF1328) FEE38_10860 ENOG4105K3G Periplasmic Protein FEE38_10865 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FEE38_10870 ENOG4105PAD Hydrolase FEE38_10875 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FEE38_10880 ENOG4108WPU DNA polymerase III subunit psi FEE38_10885 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FEE38_10905 ENOG4105YBH Protein of unknown function (DUF1435) FEE38_10910 ENOG4106TD9 Diguanylate cyclase FEE38_10915 ENOG4108819 ferric iron reductase FEE38_10920 ENOG4105CK1 PTS System FEE38_10925 ENOG4108UIN ybak prolyl-trna synthetase associated region FEE38_10930 ENOG4108T94 DNA-binding transcriptional activator BglJ FEE38_10935 ENOG4108N8T regulatoR FEE38_10945 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase FEE38_10950 ENOG4105DWK Membrane FEE38_10955 ENOG4107XM3 UPF0442 protein FEE38_10960 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) FEE38_10965 ENOG4106CVF DNA replication protein FEE38_10970 ENOG4105RI1 glycoprotein receptor FEE38_10980 ENOG4105DNE Transposase FEE38_10995 ENOG4105F3R pts system mannose fructose sorbose family iid FEE38_11000 ENOG4105ETZ PTS System FEE38_11005 ENOG4105KPI PTS system sorbose subfamily IIB component FEE38_11025 ENOG4105XYF acetyltransferase FEE38_11030 ENOG4106KNT transcriptional regulator FEE38_11035 ENOG4108RTU Aldolase FEE38_11040 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 FEE38_11045 ENOG4108IA2 Sodium pantothenate symporter FEE38_11070 ENOG4105DG4 malate L-lactate dehydrogenase FEE38_11085 ENOG4108V8F Transcriptional regulator, MarR family FEE38_11090 ENOG4105ERH Fumarylacetoacetate hydrolase FEE38_11100 ENOG4105C26 Dehydrogenase FEE38_11105 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase FEE38_11120 ENOG4105CNV Aldolase FEE38_11130 ENOG4108NKV transcriptional regulator FEE38_11135 ENOG4105EFA 4-hydroxyphenylacetate FEE38_11140 ENOG4107UWN reductase FEE38_11155 ENOG4105D22 carbon starvation protein FEE38_11160 ENOG4105VCD cytoplasmic protein FEE38_11165 ENOG4105CKI cobalamin synthesis protein FEE38_11175 ENOG4105C26 Dehydrogenase FEE38_11180 ENOG4105DNE Transposase FEE38_11185 ENOG4106AXJ AraC family transcriptional regulator FEE38_11195 ENOG4106BRA Membrane FEE38_11200 ENOG41083G8 Multidrug resistance protein MdtM FEE38_11210 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase FEE38_11215 ENOG4105CIZ coA-substrate-specific enzyme activase FEE38_11230 ENOG4105EFX secretion protein, HlyD family FEE38_11240 ENOG4106DIZ Domain of unknown function (DUF1127) FEE38_11245 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FEE38_11255 ENOG41064T2 transcriptional regulator, lysR family FEE38_11260 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FEE38_11265 ENOG4105CNN ABC, transporter FEE38_11270 ENOG4105CNN ABC, transporter FEE38_11280 ENOG4105C2J ABC transporter FEE38_11285 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FEE38_11295 ENOG4105D0S secretion protein (HlyD FEE38_11300 ENOG4105CJ1 ABC, transporter FEE38_11305 ENOG4105CMI transporter FEE38_11335 ENOG4105EZE Cupin 4 family protein FEE38_11350 ENOG4105GR3 Histidine kinase FEE38_11355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FEE38_11360 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FEE38_11365 ENOG410624V efflux system protein FEE38_11370 ENOG4105EP1 Efflux transporter rnd family, mfp subunit FEE38_11375 ENOG4108IJF Heavy metal efflux pump, CzcA FEE38_11385 ENOG4105QNF Outer membrane lipoprotein FEE38_11390 ENOG4108XDN Transcriptional regulator FEE38_11400 ENOG4107FW0 short-chain dehydrogenase reductase FEE38_11415 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FEE38_11435 ENOG4107SEY Conserved Protein FEE38_11440 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FEE38_11445 ENOG4105C93 Xylose Isomerase FEE38_11450 ENOG4105CT4 transporter FEE38_11455 ENOG4105DSG hydrolase family 43 FEE38_11475 ENOG4107S6X Glycosyl transferase, family 2 FEE38_11640 ENOG4105CVR type I restriction-modification system FEE38_11650 ENOG4105DZR Type I site-specific deoxyribonuclease FEE38_11730 ENOG41077A9 carbonic anhydrase FEE38_11735 ENOG4105CHH sulfate transporter FEE38_11740 ENOG4105DQ4 alcohol dehydrogenase FEE38_11750 ENOG4105DRS transport system, permease FEE38_11755 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FEE38_11760 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FEE38_11770 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FEE38_11775 ENOG4105F0H myo-inositol catabolism protein FEE38_11780 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FEE38_11785 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FEE38_11790 ENOG4105D7K pfkb domain protein FEE38_11795 ENOG4105CHC glucokinase (EC 2.7.1.2) FEE38_11805 ENOG4105DH8 myo-inositol catabolism FEE38_11810 ENOG4105C26 Dehydrogenase FEE38_11820 ENOG4105D7A ATP-binding protein FEE38_11825 ENOG4108K5H permease YjgP YjgQ family protein FEE38_11830 ENOG4108M8S permease YjgP YjgQ family protein FEE38_11835 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FEE38_11840 ENOG4105MYG DNA polymerase iii, chi subunit FEE38_11845 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FEE38_11850 ENOG4108MJ3 acetyltransferase FEE38_11855 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase FEE38_11860 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) FEE38_11870 ENOG4105FDP GntR family transcriptional regulator FEE38_11875 ENOG4105CSX c4-dicarboxylate anaerobic carrier FEE38_11880 ENOG4105CI2 imidazolone-5-propionate hydrolase FEE38_11885 ENOG4108KPW sugar kinase FEE38_11890 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine FEE38_11895 ENOG4105XEP YhcH YjgK YiaL family protein FEE38_11910 ENOG4105CXT aspartate transcarbamylase FEE38_11915 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) FEE38_11920 ENOG4105KME endoribonuclease L-psp FEE38_11930 ENOG4105D4X repressor FEE38_11935 ENOG4105C5Y PTS System FEE38_11940 ENOG4105CG3 alpha amylase, catalytic region FEE38_11945 ENOG4105CK1 PTS System FEE38_11950 ENOG4105F8D glycoside hydrolase family 4 FEE38_11965 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FEE38_11970 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FEE38_11975 ENOG4105K4U addiction module toxin, RelE StbE family FEE38_11985 ENOG4105EMD TRANSCRIPTIONal FEE38_11990 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FEE38_12005 ENOG41069H0 dihydroorotase EC 3.5.2.3 FEE38_12035 ENOG4108XVM Cytochrome b(562) FEE38_12040 ENOG4105CMS peptidase U62, modulator of DNA gyrase FEE38_12045 ENOG4105N42 UPF0307 protein FEE38_12060 ENOG4105DFU Cell wall formation (By similarity) FEE38_12070 ENOG41062B0 ABC transporter, permease FEE38_12075 ENOG4107R9N ABC transporter FEE38_12080 ENOG4105C2J ABC transporter FEE38_12085 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator FEE38_12090 ENOG4105F0N pyrophosphate phospho-hydrolase FEE38_12105 ENOG4108ZHD aig2 family FEE38_12110 ENOG4105MA0 exported protein FEE38_12115 ENOG4105CFU surface antigen FEE38_12130 ENOG4105D9Q decarboxylase (Beta subunit) FEE38_12135 ENOG4107QSA Oxaloacetate decarboxylase FEE38_12150 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FEE38_12155 ENOG4105ETE Transcriptional regulator (LacI family FEE38_12170 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria FEE38_12175 ENOG4105C37 (CBS) domain FEE38_12185 ENOG4105C4C beta-galactosidase FEE38_12195 ENOG41061GZ Protein of unknown function (DUF1107) FEE38_12200 ENOG4108UUE Transcriptional regulator FEE38_12205 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FEE38_12210 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FEE38_12215 ENOG4105KVH Transcriptional regulator FEE38_12220 ENOG4105ECR NmrA family FEE38_12230 ENOG4105DXC membrane FEE38_12235 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FEE38_12245 ENOG4108V1T peptidylprolyl cis-trans isomerase FEE38_12250 ENOG4105FHY Opacity-associated protein A FEE38_12255 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FEE38_12260 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FEE38_12265 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) FEE38_12270 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FEE38_12275 ENOG4105KIT UPF0379 protein yjfY FEE38_12300 ENOG4106ETB IIa component FEE38_12310 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC FEE38_12325 ENOG4108MXZ Esterase FEE38_12330 ENOG4105WSB biofilm stress and motility protein A FEE38_12335 ENOG4105S17 UPF0379 protein yjfN FEE38_12340 ENOG4105CSU acyl-Coa dehydrogenase FEE38_12345 ENOG4105C2N RNA methyltransferase TrmH family group 3 FEE38_12350 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FEE38_12355 ENOG4105KPV Transcriptional regulator FEE38_12360 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FEE38_12375 ENOG4105EPW hflc protein FEE38_12380 ENOG4107QJR hflk protein FEE38_12385 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FEE38_12395 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FEE38_12400 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FEE38_12405 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FEE38_12410 ENOG4105K8N protein family UPF0079, ATPase FEE38_12415 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FEE38_12420 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FEE38_12440 ENOG4106TNF Periplasmic binding protein FEE38_12445 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FEE38_12450 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FEE38_12455 ENOG4105DJ4 phosphatidylserine decarboxylase FEE38_12460 ENOG4105EGS Mechanosensitive ion channel FEE38_12465 ENOG4107SC7 Inner membrane transporter yjeM FEE38_12470 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FEE38_12475 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FEE38_12480 ENOG4105E33 succinate dehydrogenase FEE38_12490 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) FEE38_12500 ENOG4105KPY Small multidrug resistance protein FEE38_12505 ENOG4106BSU Entericidin B FEE38_12515 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FEE38_12520 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FEE38_12540 ENOG4105CW0 outer membrane usher protein FEE38_12555 ENOG4108MBX Secretion Protein FEE38_12580 ENOG4108ZVF (LipO)protein FEE38_12585 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FEE38_12595 ENOG4105DVH amino acid FEE38_12600 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 FEE38_12605 ENOG4108IJ0 Aspartate ammonia-lyase FEE38_12610 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FEE38_12620 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FEE38_12625 ENOG4108SIC Transcriptional regulator FEE38_12665 ENOG4108TUY outer membrane protein PgaA FEE38_12670 ENOG4107BJW polysaccharide deacetylase FEE38_12675 ENOG4105CND Glycosyl transferase, family 2 FEE38_12695 ENOG4108ZCF integral membrane protein FEE38_12700 ENOG4105DVC DnaJ domain protein FEE38_12725 ENOG4105F8D glycoside hydrolase family 4 FEE38_12730 ENOG4108K2B transcriptional regulator FEE38_12735 ENOG4105CSH Transporter FEE38_12745 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FEE38_12750 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase FEE38_12755 ENOG4107RJJ Transcriptional regulator FEE38_12760 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG FEE38_12765 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH FEE38_12770 ENOG4105EKV Phosphonate metabolism protein FEE38_12775 ENOG4105FT8 Phosphonate metabolism FEE38_12780 ENOG4105ENV phosphonate C-P lyase system protein PhnK FEE38_12785 ENOG4105HRV phosphonate c-p lyase system protein phnl FEE38_12790 ENOG4105FD8 phosphonate metabolism protein PhnM FEE38_12795 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) FEE38_12800 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein FEE38_12810 ENOG4105BZU Histidine kinase FEE38_12815 ENOG4105C2J ABC transporter FEE38_12820 ENOG4105CNN ABC, transporter FEE38_12825 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FEE38_12855 ENOG41082ND Uncharacterized protein yjcO FEE38_12860 ENOG4105CK2 sodium dicarboxylate symporter FEE38_12870 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FEE38_12875 ENOG41062QD Membrane FEE38_12880 ENOG4107QN1 sodium solute FEE38_12895 ENOG4105CW0 outer membrane usher protein FEE38_12900 ENOG4108VCD Chaperone FEE38_12905 ENOG4105MX3 Fimbrial FEE38_12910 ENOG41067MG lrgb family FEE38_12920 ENOG4105CMU LysR family (Transcriptional regulator FEE38_12925 ENOG4105EEQ Na H antiporter FEE38_12930 ENOG4105C7N Xanthine uracil vitamin C permease FEE38_12935 ENOG4108K3A Glutathione S-transferase FEE38_12940 ENOG4108Z4X TRANSCRIPTIONal FEE38_12945 ENOG4108W3Q Transcriptional regulator FEE38_12950 ENOG4108M8H domain protein FEE38_12955 ENOG4105PMV Membrane FEE38_12980 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FEE38_12985 ENOG4105ETE Transcriptional regulator (LacI family FEE38_12990 ENOG4105ECY inositol monophosphatase FEE38_13005 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FEE38_13020 ENOG4108DMH HTH_ARAC FEE38_13025 ENOG4107RNH Outer membrane receptor FepA FEE38_13030 ENOG4105E4C Lytic transglycosylase catalytic FEE38_13035 ENOG4108UUM single-stranded DNA-binding protein FEE38_13040 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FEE38_13045 ENOG4105MSB protein, conserved in bacteria FEE38_13050 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FEE38_13060 ENOG4105CGF Aromatic amino acid aminotransferase FEE38_13065 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FEE38_13070 ENOG4105CDU Replicative dna helicase FEE38_13075 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FEE38_13080 ENOG4105P4Z Phage shock protein G FEE38_13085 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FEE38_13095 ENOG4105MYN Zinc uptake regulation protein FEE38_13100 ENOG4105VDW Csbd family FEE38_13105 ENOG4107R73 Mate efflux family protein FEE38_13110 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FEE38_13115 ENOG41080IJ Diacylglycerol kinase FEE38_13120 ENOG4105E55 glycerol-3-phosphate acyltransferase FEE38_13125 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FEE38_13130 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) FEE38_13135 ENOG4107W52 maltose operon periplasmic protein FEE38_13140 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FEE38_13145 ENOG4108IJ9 (ABC) transporter FEE38_13150 ENOG4107FKK extracellular solute-binding protein family 1 FEE38_13155 ENOG4105D56 permease protein FEE38_13160 ENOG4105EG2 ABC transporter, permease FEE38_13165 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FEE38_13170 ENOG4105CEM UPF0597 protein FEE38_13185 ENOG4105KME endoribonuclease L-psp FEE38_13195 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FEE38_13200 ENOG4107QP8 phosphohexose isomerase FEE38_13205 ENOG4105CFH Aspartokinase FEE38_13210 ENOG4105C09 Bile acid FEE38_13215 ENOG4108ZR5 Conserved Protein FEE38_13220 ENOG4105FE9 pseudouridine synthase FEE38_13225 ENOG4105DKT Transcriptional regulator FEE38_13230 ENOG4105CHR reductase FEE38_13235 ENOG4108XCU pts system FEE38_13240 ENOG4105KPI PTS system sorbose subfamily IIB component FEE38_13245 ENOG4105ETZ PTS System FEE38_13250 ENOG4105F3R pts system mannose fructose sorbose family iid FEE38_13255 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein FEE38_13260 ENOG4105F9E Shikimate 5-dehydrogenase FEE38_13265 ENOG4105EAM Na Pi-cotransporter FEE38_13270 ENOG4105C3R Methionine synthase FEE38_13275 ENOG41069M3 Transcriptional regulator FEE38_13280 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) FEE38_13285 ENOG4108I9X Isocitrate lyase FEE38_13290 ENOG4107QP3 malate synthase g FEE38_13295 ENOG4105CVG Homoserine O-transsuccinylase FEE38_13300 ENOG4105K5X acetyltransferase FEE38_13330 ENOG4105DC1 bifunctional purine biosynthesis protein purh FEE38_13335 ENOG4105C12 Phosphoribosylglycinamide synthetase FEE38_13345 ENOG4105BZU Histidine kinase FEE38_13350 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism FEE38_13355 ENOG4108T8B Protein of unknown function (DUF1481) FEE38_13360 ENOG4105K70 DNA-binding protein FEE38_13365 ENOG4105R2J Conserved Protein FEE38_13370 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) FEE38_13375 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FEE38_13380 ENOG4105E09 nadh pyrophosphatase FEE38_13385 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) FEE38_13390 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FEE38_13395 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FEE38_13400 ENOG4105D06 uba thif-type nad fad binding protein FEE38_13405 ENOG4105WHD thiamine biosynthesis protein ThiS FEE38_13410 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FEE38_13415 ENOG4105D41 biosynthesis protein thiH FEE38_13420 ENOG4106TD9 Diguanylate cyclase FEE38_13430 ENOG4105VCP PTS System FEE38_13435 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FEE38_13440 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FEE38_13445 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FEE38_13450 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FEE38_13455 ENOG4108VZM 50s ribosomal protein L10 FEE38_13460 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FEE38_13465 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FEE38_13470 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FEE38_13475 ENOG4105PM1 preprotein translocase subunit SecE FEE38_13480 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FEE38_13505 ENOG4105CS9 pantothenic acid kinase FEE38_13510 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FEE38_13545 ENOG4108RR8 protoporphyrinogen oxidase FEE38_13550 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FEE38_13555 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FEE38_13560 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) FEE38_13565 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) FEE38_13570 ENOG4105CHU acetyl-coa acetyltransferase FEE38_13575 ENOG4107QK7 reductase FEE38_13580 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FEE38_13585 ENOG4105MDZ Transcriptional activator rfaH FEE38_13595 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FEE38_13600 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FEE38_13605 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FEE38_13610 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FEE38_13615 ENOG4105JC1 sterol-binding domain protein FEE38_13620 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FEE38_13625 ENOG4105CGY Dna recombination protein FEE38_13630 ENOG4107SXA Phosphorylase FEE38_13635 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FEE38_13640 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FEE38_13645 ENOG4105DZ2 Transcriptional regulator FEE38_13650 ENOG4105EMK carboxylate amino acid amine transporter FEE38_13655 ENOG4105DQF Hydrolase FEE38_13660 ENOG4108EUD Lysophospholipase FEE38_13665 ENOG410829K Lysine exporter protein (Lyse ygga) FEE38_13675 ENOG4105CCF Lysine exporter protein (Lyse ygga) FEE38_13680 ENOG4105C9U ATP-dependent DNA helicase RecQ FEE38_13685 ENOG4105HDD phospholipase FEE38_13690 ENOG4108VUY thioesterase Superfamily protein FEE38_13695 ENOG4105FR1 rard protein FEE38_13700 ENOG4107QUT magnesium and cobalt transport protein CorA FEE38_13705 ENOG4105C4R Atp-dependent dna helicase FEE38_13710 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant FEE38_13715 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FEE38_13720 ENOG4105CT0 Protein of unknown function, DUF484 FEE38_13730 ENOG4105S7Z (LipO)protein FEE38_13735 ENOG4105XQ6 frataxin-like protein FEE38_13740 ENOG4107T0K Adenylate cyclase FEE38_13745 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FEE38_13750 ENOG41076E6 Uroporphyrinogen-III Synthase FEE38_13755 ENOG4105ECF c-methyltransferase FEE38_13760 ENOG410601J HemY protein FEE38_13785 ENOG4105C85 amino acid FEE38_13790 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family FEE38_13795 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) FEE38_13800 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) FEE38_13805 ENOG4105EGZ biosynthesis protein FEE38_13810 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FEE38_13815 ENOG4108WJ1 acetyltransferase FEE38_13820 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FEE38_13825 ENOG4105C1B dTDP-glucose 4-6-dehydratase FEE38_13830 ENOG4107QQG Dehydrogenase FEE38_13835 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FEE38_13840 ENOG4105SFE lipopolysaccharide biosynthesis protein FEE38_13845 ENOG4105ESV Glycosyl transferase, family 4 FEE38_13850 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FEE38_13865 ENOG4105C1J atp-dependent rna helicase FEE38_13870 ENOG4105C9X ppx gppa phosphatase FEE38_13885 ENOG4108UQV Membrane FEE38_13890 ENOG4105C4R Atp-dependent dna helicase FEE38_13895 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FEE38_13900 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FEE38_13905 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FEE38_13910 ENOG4105EMY transcriptional regulator FEE38_13915 ENOG4105C7B Threonine dehydratase FEE38_13920 ENOG4105C01 Dihydroxy-acid dehydratase FEE38_13925 ENOG4105CM2 brancheD-chain amino acid aminotransferase FEE38_13930 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit FEE38_13945 ENOG4105C0P Mg chelatase subunit ChlI FEE38_13950 ENOG4108WFC UPF0438 protein yifE FEE38_14005 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) FEE38_14010 ENOG4108Y73 Membrane FEE38_14015 ENOG4105EJ2 Transcriptional regulator FEE38_14020 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FEE38_14025 ENOG4105C5Q Transcriptional regulator FEE38_14030 ENOG4105CH7 arginosuccinase FEE38_14035 ENOG4105CAS nag kinase FEE38_14040 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FEE38_14055 ENOG4108MEK Metal-binding protein YodA FEE38_14060 ENOG4106R3P AraC family transcriptional regulator FEE38_14065 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FEE38_14070 ENOG4105DCT glycerol dehydrogenase FEE38_14075 ENOG4108Q5Y Membrane FEE38_14080 ENOG4105SYT Methylenetetrahydrofolate reductase FEE38_14085 ENOG4105CN8 Transcriptional regulator FEE38_14090 ENOG4108Z8I decarboxylase FEE38_14095 ENOG4105CGH 5'-nucleotidase FEE38_14105 ENOG4105CFH Aspartokinase FEE38_14110 ENOG4105C28 cystathionine FEE38_14115 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) FEE38_14120 ENOG4105VFB Binds the 23S rRNA (By similarity) FEE38_14125 ENOG4105C25 Primosomal protein n' FEE38_14130 ENOG4105ETE Transcriptional regulator (LacI family FEE38_14135 ENOG41063M6 Cell Division Protein FEE38_14140 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FEE38_14150 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FEE38_14155 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FEE38_14160 ENOG4105CTQ phosphohexokinase FEE38_14165 ENOG41076HS cation diffusion facilitator family transporter FEE38_14170 ENOG4105FMW periplasmic FEE38_14175 ENOG4105E3W Two component transcriptional regulator (Winged helix family FEE38_14180 ENOG4105E0F Histidine kinase FEE38_14185 ENOG4108RPX mosc domain containing protein FEE38_14190 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FEE38_14195 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) FEE38_14200 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) FEE38_14205 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) FEE38_14215 ENOG4105DET Rhamnulokinase FEE38_14220 ENOG4105DKG l-rhamnose isomerase FEE38_14225 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) FEE38_14230 ENOG4105D4B ABC, transporter FEE38_14235 ENOG4105C2J ABC transporter FEE38_14240 ENOG4105CNN ABC, transporter FEE38_14245 ENOG4105CNN ABC, transporter FEE38_14250 ENOG4105C0A alcohol dehydrogenase FEE38_14260 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FEE38_14305 ENOG4105D2N Aldolase FEE38_14320 ENOG4105CTQ phosphohexokinase FEE38_14330 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FEE38_14340 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FEE38_14345 ENOG4108MG3 formate dehydrogenase FEE38_14350 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) FEE38_14360 ENOG41068KX affects formate dehydrogenase-N FEE38_14370 ENOG4105SUU thioesterase domain FEE38_14375 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FEE38_14380 ENOG4107S2Z UPF0761 membrane protein FEE38_14385 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 FEE38_14390 ENOG4105CI3 gtp-binding protein typa FEE38_14395 ENOG4105C5F glutamine synthetase FEE38_14400 ENOG4105CUX Signal transduction histidine kinase FEE38_14405 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FEE38_14410 ENOG4106FIY FEE38_14415 ENOG4105D4P Coproporphyrinogen iii oxidase FEE38_14425 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) FEE38_14430 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FEE38_14435 ENOG4105C2M dna polymerase I FEE38_14440 ENOG4106HNH Acyl-transferase FEE38_14445 ENOG4108Z33 Thiol disulfide Interchange Protein FEE38_14450 ENOG4105E27 serine threonine protein kinase FEE38_14455 ENOG4105PC1 Conserved Protein FEE38_14460 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FEE38_14465 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b FEE38_14495 ENOG4107EJG GntR family transcriptional regulator FEE38_14500 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEE38_14505 ENOG4105ETE Transcriptional regulator (LacI family FEE38_14510 ENOG4108RVA ribokinase FEE38_14515 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FEE38_14520 ENOG4105CNN ABC, transporter FEE38_14525 ENOG4105C2J ABC transporter FEE38_14535 ENOG4105DFH Transport of potassium into the cell (By similarity) FEE38_14550 ENOG4105CU9 asparagine synthetase A FEE38_14555 ENOG4108VVK transcriptional Regulator, AsnC FEE38_14560 ENOG4105QTB Flavodoxin FEE38_14565 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FEE38_14570 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FEE38_14575 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation FEE38_14595 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FEE38_14600 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FEE38_14605 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FEE38_14610 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FEE38_14615 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FEE38_14625 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FEE38_14630 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FEE38_14635 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FEE38_14640 ENOG4105C8U phosphate abc transporter FEE38_14645 ENOG4105E2Z phosphate ABC transporter (Permease FEE38_14655 ENOG4105ES1 acyl-CoA reductase FEE38_14665 ENOG4108M8W Monooxygenase FEE38_14715 ENOG4105DYC esterase FEE38_14720 ENOG4107VKM 6-phosphogluconolactonase FEE38_14725 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 FEE38_14735 ENOG4105C7N Xanthine uracil vitamin C permease FEE38_14740 ENOG4108YYH Nadph-dependent fmn reductase FEE38_14755 ENOG4105C2C drug resistance transporter, Bcr CflA FEE38_14765 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FEE38_14770 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FEE38_14775 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FEE38_14785 ENOG4105VG0 50S ribosomal protein l34 FEE38_14795 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FEE38_14800 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FEE38_14805 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FEE38_14810 ENOG410667J hydrolase FEE38_14825 ENOG4105EMF GntR family transcriptional regulator FEE38_14830 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 FEE38_14835 ENOG4108RTU Aldolase FEE38_14840 ENOG4105CXK mandelate racemase muconate lactonizing FEE38_14845 ENOG4105DJB Major Facilitator Superfamily FEE38_14850 ENOG4105D99 atp gtp-binding protein FEE38_14855 ENOG4105R2A (LipO)protein FEE38_14870 ENOG4105F5P DNA-damage-inducible protein d FEE38_14875 ENOG4105D0C transport protein FEE38_14880 ENOG4105FDP GntR family transcriptional regulator FEE38_14885 ENOG4105CI1 PTS System FEE38_14890 ENOG4105F8D glycoside hydrolase family 4 FEE38_14895 ENOG4105VG5 Membrane FEE38_14900 ENOG4105JP4 Inner membrane protein yidG FEE38_14920 ENOG4105W8I Transcriptional regulator FEE38_14925 ENOG4105E5M Multidrug resistance protein D FEE38_14950 ENOG4105C7K acetolactate synthase FEE38_14955 ENOG4105M71 acetolactate synthase 1 regulatory subunit FEE38_14960 ENOG4108KX4 response regulator FEE38_14965 ENOG4105BZU Histidine kinase FEE38_14970 ENOG4105CXY transporter FEE38_14975 ENOG4105CXY transporter FEE38_14980 ENOG4108SAJ Protein of unknown function (DUF1198) FEE38_15000 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FEE38_15005 ENOG4107STF Involved in phosphonate degradation (By similarity) FEE38_15015 ENOG4106S9K Transcriptional regulator FEE38_15030 ENOG4108MP3 ABC transporter, permease FEE38_15040 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FEE38_15045 ENOG4105VCP PTS System FEE38_15050 ENOG4105CK1 PTS System FEE38_15060 ENOG4105ETE Transcriptional regulator (LacI family FEE38_15065 ENOG4105D2S major facilitator superfamily FEE38_15075 ENOG4107F9Y LysR family transcriptional regulator FEE38_15085 ENOG4105JSC dimethylmenaquinone methyltransferase FEE38_15100 ENOG4105T8A Uncharacterized protein YicS FEE38_15105 ENOG4108UZ3 Transporter FEE38_15110 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) FEE38_15115 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FEE38_15120 ENOG4105C2C drug resistance transporter, Bcr CflA FEE38_15125 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FEE38_15130 ENOG4105BZS acriflavin resistance protein FEE38_15135 ENOG4105C1P efflux transporter, rnd family, mfp subunit FEE38_15155 ENOG410630P Transcriptional regulator FEE38_15165 ENOG4105CR8 Transcriptional regulator FEE38_15190 ENOG4105D01 (LipO)protein FEE38_15205 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein FEE38_15215 ENOG4105DQ4 alcohol dehydrogenase FEE38_15235 ENOG4105NI3 Protein of unknown function (DUF3237) FEE38_15250 ENOG4105CT4 transporter FEE38_15255 ENOG4105CJQ hydrolase, family 31 FEE38_15265 ENOG4105F8D glycoside hydrolase family 4 FEE38_15270 ENOG4105CI1 PTS System FEE38_15275 ENOG4105JV1 AsmA family FEE38_15285 ENOG4105C2W permease FEE38_15290 ENOG4105D6U Sodium Glutamate Symporter FEE38_15295 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FEE38_15300 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FEE38_15305 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) FEE38_15310 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FEE38_15325 ENOG4105CP7 Triose-phosphate isomerase FEE38_15330 ENOG4105EBK exported protein FEE38_15335 ENOG4108VTS Membrane FEE38_15340 ENOG4105DP0 ferredoxin-NADP reductase FEE38_15345 ENOG4105CBT Fructose-1,6-bisphosphatase FEE38_15350 ENOG4105CB5 ATP-dependent DNA helicase recG FEE38_15355 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FEE38_15360 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FEE38_15370 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FEE38_15375 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) FEE38_15380 ENOG4105EN6 Membrane FEE38_15390 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FEE38_15395 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) FEE38_15400 ENOG4105DSJ YicC domain protein FEE38_15415 ENOG4105CJ1 ABC, transporter FEE38_15420 ENOG4107QWP ABC-2 type transporter FEE38_15425 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FEE38_15440 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FEE38_15445 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FEE38_15450 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FEE38_15455 ENOG4105W5Q DNA repair protein (RadC FEE38_15460 ENOG4105KDC 50s ribosomal protein l28 FEE38_15465 ENOG4105W0E 50S ribosomal protein L33 FEE38_15470 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FEE38_15475 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FEE38_15480 ENOG4106WTF Glycosyl transferase, family 2 FEE38_15485 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FEE38_15490 ENOG4105K64 Glycosyl transferase, family 2 FEE38_15495 ENOG4105CPK Glycosyl transferase (Group 1 FEE38_15505 ENOG4105DKP glycosyl transferase, family 9 FEE38_15530 ENOG4105D16 lipopolysaccharide heptosyltransferase i FEE38_15535 ENOG4105XA0 heptosyltransferase ii FEE38_15540 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FEE38_15545 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FEE38_15550 ENOG4105CPQ Dehydrogenase FEE38_15555 ENOG4106WTF Glycosyl transferase, family 2 FEE38_15560 ENOG4105PXI polysaccharide deacetylase FEE38_15565 ENOG41063SB peptidase FEE38_15575 ENOG4107YZP Rhodanese domain protein FEE38_15580 ENOG4105VW4 glutaredoxin 3 FEE38_15585 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) FEE38_15590 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FEE38_15595 ENOG4105D7W serine acetyltransferase FEE38_15600 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FEE38_15605 ENOG4105DMF Dehydrogenase FEE38_15610 ENOG41073TP transcriptional regulator FEE38_15615 ENOG4105DAA L-lactate FEE38_15620 ENOG4108YYI Protein of unknown function (DUF2810) FEE38_15630 ENOG4105E61 Mannitol repressor protein FEE38_15635 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FEE38_15640 ENOG4105CTS PTS system mannitol-specific FEE38_15645 ENOG4105FP6 Protein of unknown function (DUF3302) FEE38_15650 ENOG4105EFX secretion protein, HlyD family FEE38_15655 ENOG4108U78 Glutathione S-transferase FEE38_15660 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) FEE38_15665 ENOG4105EM7 Selenocysteine-specific translation elongation factor FEE38_15670 ENOG4105J4Q Transcriptional regulator FEE38_15675 ENOG4108RC0 Electron transport protein FEE38_15680 ENOG4105JKW Valine--pyruvate aminotransferase FEE38_15685 ENOG4107T9C Alpha amylase catalytic region FEE38_15690 ENOG4108UR8 BAX protein FEE38_15695 ENOG4105T16 Transcriptional regulator (AraC family) FEE38_15710 ENOG4105DFW ABC transporter FEE38_15715 ENOG4105C93 Xylose Isomerase FEE38_15720 ENOG4105CMG Carbohydrate kinase FEE38_15725 ENOG410688U Inner membrane protein yiaB FEE38_15730 ENOG4108Z12 YiaAB two helix domain-containing protein FEE38_15735 ENOG4105MEV Acyl-transferase FEE38_15745 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FEE38_15750 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FEE38_15760 ENOG41060TC Hok gef cell toxic protein FEE38_15775 ENOG4105MVF Transcriptional regulator FEE38_15780 ENOG4105D2S major facilitator superfamily FEE38_15790 ENOG4106JH6 (LipO)protein FEE38_15795 ENOG4105C5I Dehydrogenase FEE38_15805 ENOG4105D7K pfkb domain protein FEE38_15815 ENOG4108M60 Transcriptional regulator FEE38_15820 ENOG4108ZG0 Ompa motb domain protein FEE38_15825 ENOG4107QY8 reductase FEE38_15830 ENOG4105HNP -acetyltransferase FEE38_15835 ENOG4108R3E Dna-3-methyladenine glycosylase i FEE38_15840 ENOG4105EAX Putative lipase FEE38_15845 ENOG4105FCD Major Facilitator FEE38_15850 ENOG4105DIJ Phosphoethanolamine transferase FEE38_15870 ENOG4105DEF Extracellular solute-binding protein, family 5 FEE38_15875 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FEE38_15880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FEE38_15885 ENOG4105C3U ABC transporter FEE38_15890 ENOG4108JQ7 (ABC) transporter FEE38_15905 ENOG4107U53 septum site-determining protein minD FEE38_15910 ENOG4107QZ7 Cellulose synthase catalytic subunit FEE38_15915 ENOG4107EEX Cellulose synthase regulator protein FEE38_15920 ENOG4105EJG cellulose synthase FEE38_15945 ENOG4105D1V cellulose synthase operon protein YhjU FEE38_15950 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT FEE38_15955 ENOG4105U74 cellulose biosynthesis protein BcsE FEE38_15960 ENOG410661M cytoplasmic protein FEE38_15965 ENOG4105UTS cellulose synthase operon protein YhjQ FEE38_15970 ENOG4107QZ7 Cellulose synthase catalytic subunit FEE38_15975 ENOG4107EEX Cellulose synthase regulator protein FEE38_15980 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FEE38_15985 ENOG4105EJG cellulose synthase FEE38_15990 ENOG4105BZU Histidine kinase FEE38_15995 ENOG4105CK2 sodium dicarboxylate symporter FEE38_16000 ENOG4105CS0 peptidase FEE38_16015 ENOG41066T0 asmA family FEE38_16020 ENOG4105CSH Transporter FEE38_16025 ENOG4107H3J ribonuclease FEE38_16030 ENOG4105CBN LysR family transcriptional regulator FEE38_16035 ENOG4105CHR reductase FEE38_16050 ENOG4105C0A alcohol dehydrogenase FEE38_16060 ENOG4105DC8 reductase FEE38_16065 ENOG4105D6S protein involved in catabolism of external DNA FEE38_16070 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FEE38_16075 ENOG4105DGW oligopeptidase A FEE38_16080 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) FEE38_16085 ENOG4105DUX Transporter FEE38_16095 ENOG4108V6B universal stress protein B FEE38_16100 ENOG4105CJ3 phosphate transporter FEE38_16105 ENOG4105CBX hi0933 family FEE38_16110 ENOG4105CJW magnesium transporter FEE38_16120 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) FEE38_16130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FEE38_16135 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FEE38_16140 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FEE38_16150 ENOG4105PY6 Phenolic acid decarboxylase FEE38_16155 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FEE38_16160 ENOG4105CKK Glycosyl transferase, family 2 FEE38_16165 ENOG4105C3I Nad-dependent epimerase dehydratase FEE38_16170 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FEE38_16175 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FEE38_16180 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FEE38_16185 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FEE38_16190 ENOG4105DSF transport protein FEE38_16195 ENOG4105F9N Major Facilitator Superfamily FEE38_16200 ENOG4108W1V Lipoprotein FEE38_16205 ENOG4105EX9 Membrane FEE38_16210 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FEE38_16220 ENOG4107FS9 Membrane FEE38_16230 ENOG4105MG3 Membrane FEE38_16235 ENOG4106H78 methyltransferase FEE38_16240 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FEE38_16245 ENOG4105CAK Cell division ATP-binding protein ftsE FEE38_16250 ENOG4105CRP Part of the ABC transporter FtsEX involved in FEE38_16265 ENOG4108JPW Aminotransferase FEE38_16275 ENOG4105CP9 extracellular ligand-binding receptor FEE38_16280 ENOG4105U59 -acetyltransferase FEE38_16290 ENOG4105CP9 extracellular ligand-binding receptor FEE38_16295 ENOG4105C32 Amino acid ABC transporter (Permease) FEE38_16300 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FEE38_16305 ENOG4105C0Z ABC transporter FEE38_16310 ENOG4108IV0 ABC, transporter FEE38_16315 ENOG41060M8 Pfam:PhdYeFM FEE38_16325 ENOG4105BZ7 extracellular solute-binding protein family 1 FEE38_16330 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FEE38_16345 ENOG4107T6V glycerophosphoryl diester phosphodiesterase FEE38_16350 ENOG4105WC8 Conserved Protein FEE38_16355 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FEE38_16360 ENOG4105WCN acetyltransferase FEE38_16370 ENOG4105D9R oxidoreductase FEE38_16375 ENOG4105C2I pirin domain protein FEE38_16380 ENOG4105DIQ Transcriptional regulator FEE38_16385 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FEE38_16390 ENOG4105C6Z Gluconate FEE38_16400 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FEE38_16405 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FEE38_16410 ENOG4108IUM Glycogen debranching enzyme FEE38_16415 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FEE38_16420 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FEE38_16425 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FEE38_16440 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FEE38_16445 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FEE38_16450 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) FEE38_16455 ENOG4105E98 transcriptional regulator DeoR family FEE38_16460 ENOG41061ZR Transcriptional regulator FEE38_16465 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FEE38_16470 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FEE38_16475 ENOG4105C6Z Gluconate FEE38_16480 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) FEE38_16485 ENOG4105MJ2 Competence protein FEE38_16490 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FEE38_16500 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) FEE38_16505 ENOG4105CE1 Ferrous iron transport protein b FEE38_16510 ENOG4105XFK Ferrous iron transport protein A FEE38_16515 ENOG4105BZM domain protein FEE38_16520 ENOG4108RRZ Transcription elongation factor GreB FEE38_16530 ENOG4105E0F Histidine kinase FEE38_16535 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FEE38_16545 ENOG4105VEJ Heat shock protein FEE38_16550 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 FEE38_16555 ENOG4105DQY intracellular growth attenuator FEE38_16560 ENOG4107RK2 ADP-ribose diphosphatase NudE FEE38_16565 ENOG4108JQC penicillin-binding protein 1A FEE38_16590 ENOG4105E4G Type IV pilus FEE38_16595 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FEE38_16600 ENOG4105D49 3-dehydroquinate synthase FEE38_16605 ENOG4105EGB membrane protein DamX FEE38_16610 ENOG4105DFE Dna adenine methylase FEE38_16615 ENOG4105DJV ribulose-phosphate 3-epimerase FEE38_16625 ENOG4105C31 Tryptophanyl-tRNA synthetase FEE38_16630 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FEE38_16635 ENOG4105WZK nitrite reductase NADPH small subunit FEE38_16640 ENOG4107QZF nitrite reductase NADPH large subunit FEE38_16645 ENOG4105DZC cytosine deaminase FEE38_16650 ENOG4106DTQ Protein TsgA homolog FEE38_16655 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FEE38_16660 ENOG4106195 uncharacterized protein yhfG FEE38_16665 ENOG4105MZU cell filamentation protein FEE38_16675 ENOG4105C8Y Acetylornithine aminotransferase FEE38_16680 ENOG410613R integral membrane protein, YccS YhfK family FEE38_16685 ENOG4107RYR Transcriptional regulator, Crp Fnr family FEE38_16690 ENOG4108UKZ OsmC family FEE38_16695 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) FEE38_16705 ENOG4105DNZ Alpha Beta Hydrolase FEE38_16715 ENOG4105C5H ABC transporter FEE38_16720 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FEE38_16725 ENOG4105CKD glutathione-regulated potassium-efflux system protein FEE38_16730 ENOG4105VKU nucleicacid-binding protein FEE38_16735 ENOG4108YZY peptidylprolyl cis-trans isomerase FEE38_16740 ENOG4105VRX Protein slyX homolog FEE38_16745 ENOG4108V1T peptidylprolyl cis-trans isomerase FEE38_16750 ENOG4105WWK YheO domain protein FEE38_16755 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) FEE38_16760 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FEE38_16765 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FEE38_16770 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FEE38_16775 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FEE38_16780 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FEE38_16785 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FEE38_16790 ENOG4105W53 bacterioferritin-associated ferredoxin FEE38_16795 ENOG4108UQY Iron-storage protein FEE38_16810 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FEE38_16815 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FEE38_16825 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FEE38_16830 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FEE38_16835 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FEE38_16840 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FEE38_16845 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FEE38_16850 ENOG41083MP 50s ribosomal protein l29 FEE38_16855 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FEE38_16860 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FEE38_16865 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FEE38_16880 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FEE38_16885 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FEE38_16895 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FEE38_16900 ENOG4105VPB 50S ribosomal protein L30 FEE38_16905 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FEE38_16910 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FEE38_16915 ENOG41067V7 50S ribosomal protein L36 FEE38_16920 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FEE38_16925 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FEE38_16930 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FEE38_16935 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FEE38_16940 ENOG4108ZT0 50S ribosomal protein l17 FEE38_16945 ENOG4105VTS DnaJ-like, subfamily C FEE38_16950 ENOG4105W1Y Transcriptional regulator FEE38_16955 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system FEE38_16960 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FEE38_16965 ENOG4105C1A potassium transporter peripheral membrane FEE38_16970 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FEE38_16975 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FEE38_16980 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FEE38_16985 ENOG4105C79 DNA protecting protein DprA FEE38_16995 ENOG4108WI1 Dna topoisomerase FEE38_17000 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FEE38_17005 ENOG4105E2X shikimate dehydrogenase FEE38_17010 ENOG4105SG3 Protein of unknown function (DUF1488) FEE38_17015 ENOG4108Z0R Transferase FEE38_17045 ENOG4105XCM membrane LIPOPROTEIN FEE38_17050 ENOG4105BZS acriflavin resistance protein FEE38_17055 ENOG4105C1P efflux transporter, rnd family, mfp subunit FEE38_17060 ENOG4108XG4 DNA-binding transcriptional regulator FEE38_17070 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FEE38_17080 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FEE38_17085 ENOG4108IA2 Sodium pantothenate symporter FEE38_17090 ENOG4105RG0 Membrane FEE38_17095 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FEE38_17100 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FEE38_17110 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) FEE38_17125 ENOG41062P1 Diguanylate cyclase phosphodiesterase FEE38_17135 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FEE38_17140 ENOG4105VQ7 Rod shape-determining protein MreD FEE38_17145 ENOG4108Z03 MAF-like protein FEE38_17150 ENOG4105C03 ribonuclease FEE38_17155 ENOG4105QD6 exported protein FEE38_17160 ENOG4105D1U peptidase U62 modulator of DNA gyrase FEE38_17165 ENOG4105CR8 Transcriptional regulator FEE38_17180 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) FEE38_17185 ENOG4105UNR (Barnase) inhibitor FEE38_17190 ENOG4105RID UPF0379 protein yhcN FEE38_17195 ENOG4105RID UPF0379 protein yhcN FEE38_17200 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) FEE38_17205 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FEE38_17220 ENOG4105C8P )-transporter FEE38_17225 ENOG4106DSS Tartrate dehydratase subunit alpha FEE38_17230 ENOG4107GFK fumarate FEE38_17240 ENOG4107QSA Oxaloacetate decarboxylase FEE38_17245 ENOG4105D9Q decarboxylase (Beta subunit) FEE38_17255 ENOG4105C0H protease FEE38_17260 ENOG4105C0H protease FEE38_17265 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III FEE38_17270 ENOG4105D6Z AFG1 family ATPase FEE38_17275 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FEE38_17290 ENOG4107MKT Stringent starvation protein a FEE38_17295 ENOG4105KB2 stringent starvation protein b FEE38_17300 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) FEE38_17305 ENOG4105BZ8 glutamate synthase FEE38_17310 ENOG4105CBC glutamate synthase FEE38_17315 ENOG4105N5T Radical SAM Protein FEE38_17320 ENOG4108I5G Major Facilitator superfamily FEE38_17325 ENOG4105CPQ Dehydrogenase FEE38_17330 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FEE38_17335 ENOG4105BZU Histidine kinase FEE38_17340 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain FEE38_17350 ENOG41080Z8 PHOSPHOCARRIER protein FEE38_17355 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FEE38_17360 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FEE38_17365 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FEE38_17370 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FEE38_17375 ENOG4108IUZ ABC transporter FEE38_17380 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FEE38_17385 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) FEE38_17390 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FEE38_17395 ENOG4105C2X Arabinose 5-phosphate isomerase FEE38_17400 ENOG4105FEU K -dependent Na -Ca exchanger FEE38_17410 ENOG4105DHJ ABC, transporter FEE38_17415 ENOG4105CY3 ABC transporter, permease FEE38_17420 ENOG4107PE3 Mammalian cell entry related domain protein FEE38_17425 ENOG4105E3I toluene tolerance FEE38_17430 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane FEE38_17435 ENOG4105VFK BolA family FEE38_17440 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FEE38_17445 ENOG4105HVQ Regulatory factor of maltose metabolism FEE38_17450 ENOG4105EAH synthase FEE38_17455 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FEE38_17460 ENOG4105K46 50S ribosomal protein l27 FEE38_17465 ENOG4105QYV Membrane FEE38_17470 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FEE38_17475 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FEE38_17480 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FEE38_17485 ENOG4105HBR Rna-binding protein FEE38_17490 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FEE38_17495 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FEE38_17500 ENOG4105EEI dihydropteroate synthase FEE38_17505 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FEE38_17510 ENOG4105NTZ Preprotein translocase subunit SecG FEE38_17525 ENOG4108UII YfaZ family FEE38_17530 ENOG4108PNB DNA-binding transcriptional regulator FEE38_17535 ENOG4105CDH Citrulline--aspartate ligase FEE38_17545 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FEE38_17550 ENOG4105CHV Transcription elongation factor NusA FEE38_17555 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FEE38_17560 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FEE38_17565 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FEE38_17570 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FEE38_17575 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FEE38_17590 ENOG4105C1J atp-dependent rna helicase FEE38_17595 ENOG4105CIC tryptophan-specific transport protein FEE38_17600 ENOG4105DEN Luciferase family FEE38_17620 ENOG4108YYD acetyltransferase FEE38_17625 ENOG41082IR Excinuclease ABC C subunit domain protein FEE38_17630 ENOG4108ZPB UPF0306 protein FEE38_17635 ENOG4107R7Y intracellular protease Pfpi family FEE38_17640 ENOG4105K4T epimerase FEE38_17645 ENOG4107S21 permease FEE38_17650 ENOG4105W4M Transport-associated protein FEE38_17655 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FEE38_17660 ENOG41082RQ UPF0102 protein FEE38_17665 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) FEE38_17670 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FEE38_17675 ENOG4105CTX dehydratase FEE38_17680 ENOG4105DJB Major Facilitator Superfamily FEE38_17685 ENOG4105CNV Aldolase FEE38_17690 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FEE38_17695 ENOG4105BZW Glycerate kinase FEE38_17715 ENOG4108CNN domain protein FEE38_17720 ENOG4105CWB LysR family transcriptional Regulator FEE38_17725 ENOG4105KAF membrAne FEE38_17730 ENOG4105CHF Glutathione S-transferase FEE38_17735 ENOG4108VBZ doxx family FEE38_17740 ENOG4105YJD FEE38_17745 ENOG41090KG Inner membrane protein YqjE FEE38_17750 ENOG4105NE1 Conserved Protein FEE38_17755 ENOG4105WAY exported protein FEE38_17760 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) FEE38_17765 ENOG4106W5V Membrane FEE38_17770 ENOG4107YCY Transcriptional regulator FEE38_17775 ENOG4105DPW Major facilitator superfamily MFS_1 FEE38_17785 ENOG4105CTX dehydratase FEE38_17790 ENOG4105P66 Membrane FEE38_17795 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) FEE38_17800 ENOG4105DU1 integral membrane protein, terc FEE38_17805 ENOG4105EE0 oxidoreductase FEE38_17810 ENOG4108VKG metal-dependent hydrolase FEE38_17825 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FEE38_17830 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FEE38_17835 ENOG4107RYS Autoinducer-2 (AI-2) kinase FEE38_17840 ENOG4105DKT Transcriptional regulator FEE38_17845 ENOG4105C2J ABC transporter FEE38_17850 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FEE38_17855 ENOG4105F5R ABC transporter FEE38_17860 ENOG4105D4B ABC, transporter FEE38_17865 ENOG41061GT Aldolase FEE38_17870 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound FEE38_17875 ENOG4105C8Y Acetylornithine aminotransferase FEE38_17880 ENOG4105NTW Transcriptional regulator FEE38_17885 ENOG4105Q26 Siderophore-interacting protein FEE38_17900 ENOG4108UTZ Dihydroxyacetone kinase FEE38_17905 ENOG4105CMT Dihydroxyacetone kinase FEE38_17940 ENOG4105C0A alcohol dehydrogenase FEE38_17965 ENOG4105YCI dehydratase medium subunit FEE38_17970 ENOG4108ZFT Dehydratase small subunit FEE38_17975 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit FEE38_17980 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FEE38_17985 ENOG4105XXV Acid-resistance protein FEE38_17990 ENOG4108YK4 Acid-resistance membrane protein FEE38_17995 ENOG4108V08 YfdX protein FEE38_18005 ENOG4108WQH regulatoR FEE38_18025 ENOG4108VCA G U mismatch-specific DNA glycosylase FEE38_18030 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FEE38_18035 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FEE38_18045 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FEE38_18055 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) FEE38_18060 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FEE38_18065 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) FEE38_18070 ENOG4105CQM Urea amidohydrolase subunit alpha FEE38_18075 ENOG4105KI2 Urea amidohydrolase subunit beta FEE38_18080 ENOG4108YZ9 Urea amidohydrolase subunit gamma FEE38_18085 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FEE38_18095 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FEE38_18100 ENOG4107ZVW dihydroneopterin aldolase FEE38_18105 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FEE38_18110 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FEE38_18115 ENOG4106MWK domain protein FEE38_18120 ENOG4105I7R Adenylate cyclase FEE38_18125 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FEE38_18130 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FEE38_18140 ENOG4105W0Z cytoplasmic protein FEE38_18145 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FEE38_18155 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FEE38_18160 ENOG4106032 Glutathionylspermidine synthase FEE38_18165 ENOG4105F1G UPF0441 protein FEE38_18175 ENOG41087AY ADP-Ribose pyrophosphatase FEE38_18180 ENOG4108SX3 cytoplasmic protein FEE38_18185 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FEE38_18190 ENOG4105IPS esterase FEE38_18195 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FEE38_18200 ENOG4105VRH Antibiotic biosynthesis monooxygenase FEE38_18205 ENOG4105NF4 modulator of drug activity FEE38_18210 ENOG4105DHQ Histidine kinase FEE38_18215 ENOG4105XJC Two component transcriptional regulator (Winged helix family FEE38_18220 ENOG4105H4F exported protein FEE38_18225 ENOG4105F4I Transcriptional regulator FEE38_18230 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FEE38_18235 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FEE38_18240 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) FEE38_18245 ENOG4105CCT upf0313 protein FEE38_18255 ENOG4105CV8 reductase FEE38_18260 ENOG4108I6A alcohol dehydrogenase FEE38_18265 ENOG4105CF7 AraC family transcriptional regulator FEE38_18270 ENOG4108K81 inner membrane protein YghB FEE38_18275 ENOG4105C28 cystathionine FEE38_18280 ENOG4105CWK Biopolymer transport protein, ExbB FEE38_18285 ENOG4108ZZF transport protein (ExbD) FEE38_18290 ENOG4105CT4 transporter FEE38_18295 ENOG4105E4I Glycoside hydrolase family 28 FEE38_18300 ENOG4108TEB UPF0114 protein FEE38_18310 ENOG410900S Protein of unknown function (DUF2623) FEE38_18315 ENOG4105CYM Glutathione S-transferase FEE38_18325 ENOG4106032 Glutathionylspermidine synthase FEE38_18330 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FEE38_18350 ENOG4105CC0 LysR family Transcriptional regulator FEE38_18355 ENOG4105C28 cystathionine FEE38_18370 ENOG4108UQV Membrane FEE38_18380 ENOG4105CXN decarboxylase FEE38_18385 ENOG4105EAA nucleoside FEE38_18390 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FEE38_18395 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) FEE38_18400 ENOG4105CEN a g-specific adenine glycosylase FEE38_18405 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FEE38_18410 ENOG41090ED Protein with unknown function (DUF469) FEE38_18415 ENOG4105K33 Periplasmic Protein FEE38_18420 ENOG4105CSA Coproporphyrinogen iii oxidase FEE38_18425 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FEE38_18430 ENOG4105VZ9 UPF0235 protein FEE38_18435 ENOG4108VIA integral membrane protein FEE38_18440 ENOG4105DFA alanine racemase domain protein FEE38_18445 ENOG4105CZX twitching motility protein FEE38_18450 ENOG41086KC Transcriptional regulator FEE38_18455 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FEE38_18460 ENOG4108UJU UPF0301 protein FEE38_18465 ENOG4105D7Z glutathione synthase FEE38_18470 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FEE38_18475 ENOG4105RWS endonuclease I FEE38_18480 ENOG4105GPY SprT protein FEE38_18485 ENOG4107QNK )-transporter FEE38_18490 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FEE38_18505 ENOG4105CYW agmatinase FEE38_18535 ENOG4105CHR reductase FEE38_18540 ENOG4108FUF Transcriptional regulator, IclR family FEE38_18550 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase FEE38_18570 ENOG4105CHR reductase FEE38_18575 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) FEE38_18590 ENOG4105J5J Outer membrane porin FEE38_18595 ENOG4108K0D peptidase, M48 FEE38_18600 ENOG4105CV1 Transketolase (EC 2.2.1.1) FEE38_18605 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FEE38_18615 ENOG4105D2N Aldolase FEE38_18620 ENOG4105D64 Mechanosensitive ion channel FEE38_18625 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FEE38_18630 ENOG4105MPN Membrane FEE38_18635 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FEE38_18640 ENOG4105E66 phosphoriboisomerase A FEE38_18645 ENOG4108JQ1 Dehydrogenase FEE38_18650 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FEE38_18660 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FEE38_18665 ENOG4105E07 UPF0149 protein FEE38_18670 ENOG4107RAQ aminopeptidase FEE38_18675 ENOG4105D0A hydroxylase FEE38_18680 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FEE38_18685 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FEE38_18690 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FEE38_18695 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FEE38_18700 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FEE38_18710 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FEE38_18730 ENOG4105CS2 ec 3.2.1.21 FEE38_18735 ENOG4108Q3X Transcriptional regulator FEE38_18740 ENOG4105N5Z UPF0267 protein FEE38_18745 ENOG4108UT2 hemolysin iii FEE38_18755 ENOG4105Y75 tpr repeat protein FEE38_18760 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB FEE38_18765 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) FEE38_18770 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FEE38_18775 ENOG4105T95 Thiol disulfide interChange protein FEE38_18780 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FEE38_18790 ENOG4105CRK lysyL-tRNA synthetase FEE38_18795 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FEE38_18800 ENOG4108K5P (LipO)protein FEE38_18810 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEE38_18825 ENOG4105CPC Aldo Keto reductase FEE38_18840 ENOG4105W7K Transcriptional regulator FEE38_18865 ENOG4107R5R arsenical pump membrane protein FEE38_18870 ENOG4105K89 arsenate reductase FEE38_18875 ENOG4105DUX Transporter FEE38_18880 ENOG4105V2F Uncharacterized protein yoac FEE38_18885 ENOG4105ETP RND efflux system, outer membrane lipoprotein FEE38_18890 ENOG4108MI0 Resistance protein FEE38_18895 ENOG4105J12 Multidrug resistance protein mdtN FEE38_18905 ENOG4105VR1 Pfam:DUF1271 FEE38_18910 ENOG410830R acetyltransferase FEE38_18920 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin FEE38_18925 ENOG4108T65 Fimbrial FEE38_18930 ENOG4108SQA Fimbrial FEE38_18935 ENOG4105CW0 outer membrane usher protein FEE38_18940 ENOG4108NAE Fimbrial chaperone protein FEE38_18945 ENOG4108S54 Fimbrial protein FEE38_18950 ENOG4108RQP Major type 1 subunit fimbrin FEE38_18955 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off FEE38_18960 ENOG4108W9T type 1 fimbriae regulatory protein FEE38_18970 ENOG4105D7X high-affinity nickel-transporter FEE38_18975 ENOG4108ZT1 Transcriptional regulator FEE38_18980 ENOG4108KTG Membrane protein, drug metabolite transporter FEE38_18990 ENOG4108T1W Fimbrial subunit type 3 FEE38_19030 ENOG4107S5I aldo keto reductase FEE38_19035 ENOG4108MHD transport protein FEE38_19045 ENOG4105C5Q Transcriptional regulator FEE38_19050 ENOG4105CHU acetyl-coa acetyltransferase FEE38_19055 ENOG4108QGT oligogalacturonate-specific porin FEE38_19060 ENOG4105CAZ oligogalacturonide lyase FEE38_19065 ENOG4105CHR reductase FEE38_19070 ENOG4107QNK )-transporter FEE38_19075 ENOG4106NDP Transcriptional regulator FEE38_19080 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FEE38_19085 ENOG4108HKT sucrose-6-phosphate hydrolase FEE38_19100 ENOG4108IJ9 (ABC) transporter FEE38_19105 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FEE38_19110 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FEE38_19115 ENOG4105YKW FEE38_19125 ENOG4105RQF LysR family Transcriptional regulator FEE38_19135 ENOG4105DDV Transcriptional regulator (LacI family FEE38_19140 ENOG4105CK1 PTS System FEE38_19145 ENOG4105CS2 ec 3.2.1.21 FEE38_19150 ENOG4107YCY Transcriptional regulator FEE38_19160 ENOG41060NJ transcriptional regulator FEE38_19165 ENOG4105CEY Amp-dependent synthetase and ligase FEE38_19170 ENOG4107S74 Lysophospholipid transporter LplT FEE38_19175 ENOG4105CPC Aldo Keto reductase FEE38_19180 ENOG4105SUV lipoprotein YgdR FEE38_19185 ENOG4105EE5 Membrane protein terC FEE38_19190 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) FEE38_19200 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FEE38_19205 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FEE38_19210 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FEE38_19215 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FEE38_19220 ENOG4105IPU prepilin peptidase dependent protein A FEE38_19225 ENOG4105JCS prepilin peptidase dependent protein FEE38_19230 ENOG4105SEN Protein of unknown function (DUF2509) FEE38_19235 ENOG4105RVB Prepilin peptidase dependent protein c FEE38_19240 ENOG4105DSY exodeoxyribonuclease V, gamma FEE38_19245 ENOG4107QXK peptidase FEE38_19250 ENOG4107QKA exodeoxyribonuclease V beta FEE38_19255 ENOG4107QYX exodeoxyribonuclease v alpha FEE38_19265 ENOG4107QZM n-acetylglutamate synthase FEE38_19270 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FEE38_19275 ENOG4107QZB decarboxylase FEE38_19280 ENOG4105JZC GHMP kinase FEE38_19285 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FEE38_19290 ENOG4105KTW ethanolamine utilization protein FEE38_19295 ENOG4105M3W utilization protein FEE38_19305 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) FEE38_19310 ENOG4105C0A alcohol dehydrogenase FEE38_19315 ENOG4108EKI Dehydrogenase FEE38_19325 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml FEE38_19340 ENOG4105KNY Microcompartments protein FEE38_19345 ENOG4105KNY Microcompartments protein FEE38_19355 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit FEE38_19360 ENOG4108ZFT Dehydratase small subunit FEE38_19365 ENOG4105YCI dehydratase medium subunit FEE38_19375 ENOG4105EHR propanediol utilization protein pduB FEE38_19380 ENOG4105KNY Microcompartments protein FEE38_19385 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FEE38_19390 ENOG4107XVH Transcriptional regulator FEE38_19395 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FEE38_19400 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FEE38_19405 ENOG41081F0 Precorrin-8x methylmutase FEE38_19410 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) FEE38_19415 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase FEE38_19420 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase FEE38_19425 ENOG4105CIA precorrin-4 C(11)-methyltransferase FEE38_19430 ENOG4108P62 biosynthesis protein (CbiG) FEE38_19435 ENOG4105E4R Precorrin-3B C17-methyltransferase FEE38_19440 ENOG4105QUC reductase FEE38_19445 ENOG4107PPM cobalt chelatase FEE38_19450 ENOG4105DVK Precorrin-2 c20-methyltransferase FEE38_19455 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) FEE38_19460 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) FEE38_19465 ENOG4108V4M Cobalt abc transporter FEE38_19475 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FEE38_19480 ENOG4108YZT Adenosylcobinamide kinase FEE38_19485 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FEE38_19540 ENOG4108ZG0 Ompa motb domain protein FEE38_19575 ENOG4105CA3 membrane-bound lytic murein transglycosylase FEE38_19580 ENOG4105CUZ uba thif-type nad fad binding protein FEE38_19585 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FEE38_19590 ENOG4105C9B Cysteine desulfurase FEE38_19595 ENOG4105M5B (LipO)protein FEE38_19600 ENOG4105ETT transcriptional Regulator, LysR family FEE38_19605 ENOG4105M08 Membrane FEE38_19615 ENOG4107EDW L-fucose operon activator FEE38_19620 ENOG4105NWF RbsD or FucU transport FEE38_19625 ENOG4105CMG Carbohydrate kinase FEE38_19630 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) FEE38_19635 ENOG4105EDR glucose galactose transporter FEE38_19640 ENOG4107W7X Aldolase FEE38_19645 ENOG4105C0A alcohol dehydrogenase FEE38_19650 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease FEE38_19655 ENOG4108JU7 Transcriptional regulator FEE38_19660 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FEE38_19680 ENOG4108UMI ABC transporter, permease FEE38_19685 ENOG4105D01 (LipO)protein FEE38_19720 ENOG4105GVF (ABC) transporter FEE38_19725 ENOG4105EJQ L-serine dehydratase FEE38_19730 ENOG4105C44 Serine transporter FEE38_19735 ENOG4105EWT decarboxylase family FEE38_19740 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FEE38_19745 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) FEE38_19750 ENOG4105WP7 tRNA pseudouridine synthase C FEE38_19755 ENOG4105DR9 pseudouridine synthase FEE38_19760 ENOG4105QDK Flavodoxin FEE38_19765 ENOG4105DJB Major Facilitator Superfamily FEE38_19770 ENOG4105EQX glucarate dehydratase FEE38_19775 ENOG4105EQX glucarate dehydratase FEE38_19780 ENOG4105BZW Glycerate kinase FEE38_19790 ENOG4105BZU Histidine kinase FEE38_19795 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FEE38_19800 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FEE38_19805 ENOG4105DXN mazG family FEE38_19810 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FEE38_19815 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FEE38_19825 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FEE38_19830 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FEE38_19835 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FEE38_19840 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FEE38_19845 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FEE38_19850 ENOG4108MXK alkaline phosphatase isozyme conversion FEE38_19855 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FEE38_19860 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FEE38_19870 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FEE38_19875 ENOG4105N0Z inner membrane protein ygbE FEE38_19880 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FEE38_19885 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FEE38_19890 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FEE38_19895 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) FEE38_19905 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FEE38_19910 ENOG4108K5P (LipO)protein FEE38_19915 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FEE38_19940 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FEE38_19945 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FEE38_19950 ENOG4105KZM cytoplasmic protein FEE38_19965 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FEE38_19970 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FEE38_19975 ENOG4105EHG Permease protein FEE38_19980 ENOG4107R4I Periplasmic binding protein FEE38_19985 ENOG4106QJH hemin transport protein FEE38_20005 ENOG4108N2Y auxin Efflux FEE38_20015 ENOG4105VXR cytoplasmic protein FEE38_20020 ENOG4105CC5 ABC transporter FEE38_20025 ENOG4105CC5 ABC transporter FEE38_20030 ENOG4105DIK (ABC) transporter FEE38_20040 ENOG4105DDV Transcriptional regulator (LacI family FEE38_20045 ENOG4105DKQ ROK family FEE38_20050 ENOG4105VCP PTS System FEE38_20055 ENOG4105CK1 PTS System FEE38_20060 ENOG4105VZJ PTS System FEE38_20065 ENOG4105CK1 PTS System FEE38_20085 ENOG4105CS2 ec 3.2.1.21 FEE38_20095 ENOG4105C45 hydrogenase expression formation protein (HypE) FEE38_20100 ENOG4105CQS hydrogenase expression formation protein HypD FEE38_20105 ENOG41083WG hydrogenase assembly chaperone FEE38_20110 ENOG4107RSS Hydrogenase accessory protein HypB FEE38_20115 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) FEE38_20120 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA FEE38_20130 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) FEE38_20135 ENOG4107R30 NADH dehydrogenase FEE38_20140 ENOG4107TDF Formate hydrogenlyase subunit 4 FEE38_20145 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FEE38_20150 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit FEE38_20155 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit FEE38_20160 ENOG4105I6X formate hydrogenlyase maturation FEE38_20165 ENOG4108MG9 hydrogenase 3 maturation protease FEE38_20175 ENOG4105CS2 ec 3.2.1.21 FEE38_20180 ENOG4105C5Y PTS System FEE38_20185 ENOG4105DDV Transcriptional regulator (LacI family FEE38_20190 ENOG4108RC0 Electron transport protein FEE38_20195 ENOG4105C8H hydrogenase maturation protein Hypf FEE38_20205 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase FEE38_20210 ENOG4105CNW domain protein FEE38_20220 ENOG4108JUA Transcriptional regulator FEE38_20230 ENOG410804X Transcriptional regulator FEE38_20235 ENOG4105J92 DNA-binding transcriptional activator GutM FEE38_20240 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase FEE38_20245 ENOG4105VI0 Pts system, glucitol sorbitol-specific FEE38_20250 ENOG4105DZY Pts system, glucitol sorbitol-specific FEE38_20255 ENOG410787A Pts system, glucitol sorbitol-specific FEE38_20260 ENOG4105CVE Lytic murein transglycosylase FEE38_20275 ENOG4105CC5 ABC transporter FEE38_20280 ENOG4105DSE periplasmic solute binding protein FEE38_20285 ENOG4107TH8 cina domain protein FEE38_20290 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FEE38_20295 ENOG4105Y3E Modulates RecA activity (By similarity) FEE38_20300 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FEE38_20310 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FEE38_20340 ENOG4105K3G Periplasmic Protein FEE38_20345 ENOG4107VXZ Hydrolase FEE38_20350 ENOG4105W39 Membrane FEE38_20355 ENOG4105D9M gamma-glutamylcysteine synthetase FEE38_20370 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FEE38_20375 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEE38_20380 ENOG4105CW7 secretion protein, HlyD family FEE38_20385 ENOG4105NTK Transcriptional repressor Mpra FEE38_20390 ENOG4105ZED uncharacterized protein ygaH FEE38_20395 ENOG4108UMN azlc family FEE38_20400 ENOG4105GIJ Glycine betaine FEE38_20405 ENOG4108HQS Glycine betaine FEE38_20410 ENOG4108IJ7 Glycine betaine FEE38_20415 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FEE38_20420 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FEE38_20425 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FEE38_20430 ENOG4105WAZ (Glutaredoxin-like protein) NrdH FEE38_20435 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FEE38_20440 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FEE38_20445 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) FEE38_20450 ENOG4108WMJ Protein of unknown function (DUF2002) FEE38_20455 ENOG4108RNS Exports L-alanine (By similarity) FEE38_20470 ENOG4108X73 DNA- binding protein FEE38_20485 ENOG4108V62 Rhodanese domain protein FEE38_20490 ENOG41080HT Transcriptional regulator, arsr family FEE38_20500 ENOG4105CC0 LysR family Transcriptional regulator FEE38_20505 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FEE38_20515 ENOG4105X0I Fimbrial FEE38_20520 ENOG4108VCD Chaperone FEE38_20525 ENOG4105CW0 outer membrane usher protein FEE38_20540 ENOG4105CW0 outer membrane usher protein FEE38_20545 ENOG4106P2F Pfam:Pili_assembly_C FEE38_20550 ENOG4106EAR Fimbrial protein FEE38_20555 ENOG4108WQH regulatoR FEE38_20570 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FEE38_20575 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FEE38_20580 ENOG4105MP9 class II Aldolase FEE38_20590 ENOG4106TNF Periplasmic binding protein FEE38_20605 ENOG4105CYW agmatinase FEE38_20610 ENOG4105EVZ LysR family transcriptional regulator FEE38_20630 ENOG4105UEI Transcriptional Regulator AraC Family FEE38_20675 ENOG4105DFP Integrase FEE38_20685 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FEE38_20690 ENOG4108Z1B Cyclase dehydrase FEE38_20700 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FEE38_20705 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FEE38_20710 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FEE38_20715 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FEE38_20720 ENOG4108JU6 CBS domain protein FEE38_20725 ENOG4106KVJ cytochrome C assembly protein FEE38_20730 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FEE38_20735 ENOG4105K5M 30s ribosomal protein S16 FEE38_20740 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FEE38_20745 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FEE38_20750 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FEE38_20765 ENOG41090EK ompa motb domain protein FEE38_20770 ENOG4108KHX Diguanylate cyclase FEE38_20775 ENOG4108WS1 FEE38_20780 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FEE38_20785 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FEE38_20795 ENOG4105CQC Prephenate dehydratase FEE38_20805 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA FEE38_20810 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FEE38_20815 ENOG4105C34 Pseudouridine synthase FEE38_20820 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FEE38_20825 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FEE38_20860 ENOG4105CSH Transporter FEE38_20865 ENOG4105T42 (LipO)protein FEE38_20870 ENOG4105JIM Phosphatidylserine synthase FEE38_20875 ENOG4105CD5 CoA-binding domain protein FEE38_20880 ENOG4106IUH DTW domain containing protein FEE38_20885 ENOG4105K63 Thioredoxin FEE38_20890 ENOG4105EIB trna rrna methyltransferase FEE38_20895 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FEE38_20900 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) FEE38_20905 ENOG4105C1J atp-dependent rna helicase FEE38_20910 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) FEE38_20915 ENOG4108IYU L-aspartate oxidase FEE38_20930 ENOG41069PW sigma-e factor negative regulatory protein FEE38_20935 ENOG4105VQK sigma E regulatory protein, MucB RseB FEE38_20940 ENOG4105WMJ Positive regulator of sigma E, RseC MucC FEE38_20945 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FEE38_20950 ENOG4105C3F Signal peptidase i FEE38_20955 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FEE38_20960 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FEE38_20965 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FEE38_20970 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FEE38_20975 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FEE38_20980 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FEE38_20985 ENOG4106G6Q Transcriptional regulator FEE38_20990 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB FEE38_20995 ENOG4108Z6B deaminase FEE38_21000 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FEE38_21005 ENOG4108ETH Formylglycinamide ribotide synthetase FEE38_21015 ENOG4107WP9 Histidine kinase FEE38_21020 ENOG4108SKK alpha helix protein FEE38_21025 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FEE38_21030 ENOG4108YZA Nitrogen regulatory protein pii FEE38_21035 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FEE38_21040 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FEE38_21045 ENOG4108SB3 DoxX Family FEE38_21050 ENOG4108NZE NAGC-like transcriptional regulator FEE38_21055 ENOG4107HQ7 repeat protein FEE38_21060 ENOG4107QNK )-transporter FEE38_21065 ENOG4108ZKT aldose 1-epimerase FEE38_21070 ENOG4105D8G Major Facilitator superfamily FEE38_21075 ENOG4108MN2 Stationary phase inducible protein CsiE FEE38_21080 ENOG41065CD Exported protein FEE38_21085 ENOG4105D7X high-affinity nickel-transporter FEE38_21095 ENOG4105ECY inositol monophosphatase FEE38_21100 ENOG4105CVS RNA methyltransferase TrmH family, group 1 FEE38_21105 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family FEE38_21110 ENOG4105C3J Cysteine desulfurase FEE38_21115 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FEE38_21120 ENOG4108Z4V iron-sulfur cluster assembly FEE38_21125 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) FEE38_21130 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB FEE38_21135 ENOG4108ZIT Ferredoxin, 2FE-2S FEE38_21140 ENOG4105WVQ Fe-S assembly protein IscX FEE38_21145 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FEE38_21150 ENOG4105YYA enhanced serine sensitivity protein SseB FEE38_21160 ENOG4105KHC sulfurtransferase FEE38_21165 ENOG4105DN3 alpha-2-macroglobulin domain protein FEE38_21170 ENOG4108JQB penicillin-binding protein 1C FEE38_21175 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FEE38_21185 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FEE38_21190 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) FEE38_21195 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FEE38_21205 ENOG4105N21 Membrane FEE38_21210 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FEE38_21215 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FEE38_21225 ENOG4105VPD cellular component movement FEE38_21230 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FEE38_21235 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FEE38_21240 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FEE38_21280 ENOG4108PNI recT protein FEE38_21365 ENOG4105KT5 UmuD protein FEE38_21370 ENOG4108TFU terminase (Small subunit) FEE38_21515 ENOG4105NVB glycoside hydrolase, family 19 FEE38_21530 ENOG4105C4X radical SAM domain protein FEE38_21545 ENOG41062G3 Protein of unknown function (DUF2633) FEE38_21550 ENOG4105BZU Histidine kinase FEE38_21555 ENOG4105C9X ppx gppa phosphatase FEE38_21560 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FEE38_21565 ENOG4108V3E phosphoribosylglycinamide formyltransferase FEE38_21570 ENOG4105CXB phosphoribosylaminoimidazole synthetase FEE38_21575 ENOG41066F8 ROK family FEE38_21580 ENOG4105CS2 ec 3.2.1.21 FEE38_21585 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FEE38_21590 ENOG4105C2W permease FEE38_21595 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) FEE38_21605 ENOG4105K89 arsenate reductase FEE38_21610 ENOG4105ERG peptidase m48, ste24p FEE38_21615 ENOG4105C02 permease FEE38_21620 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FEE38_21625 ENOG4105RH4 Glycine cleavage system transcriptional repressor FEE38_21630 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FEE38_21635 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FEE38_21640 ENOG4105C8V SAICAR synthetase FEE38_21645 ENOG4105CGZ zinc metallopeptidase FEE38_21650 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) FEE38_21655 ENOG4106KED esterase YpfH FEE38_21660 ENOG4105XYK UPF0370 protein FEE38_21665 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FEE38_21670 ENOG4105KUZ arsenate reductase FEE38_21680 ENOG4105BZS acriflavin resistance protein FEE38_21690 ENOG4105BZ8 glutamate synthase FEE38_21695 ENOG4107VIJ nudix hydrolase FEE38_21700 ENOG4108PVD exported protein FEE38_21705 ENOG4105CV1 Transketolase (EC 2.2.1.1) FEE38_21710 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FEE38_21715 ENOG4105C6K Malic enzyme FEE38_21720 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place FEE38_21725 ENOG4106S4J ethanolamine utilization protein EutP FEE38_21730 ENOG4105NDK ethanolamine utilization protein FEE38_21735 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase FEE38_21740 ENOG4108IJ2 phosphate acetyltransferase FEE38_21745 ENOG4105KNY Microcompartments protein FEE38_21750 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml FEE38_21755 ENOG4108EKI Dehydrogenase FEE38_21760 ENOG4107YMV ethanolamine utilization protein FEE38_21780 ENOG4105ENY Ethanolamine utilization protein eutH FEE38_21785 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase FEE38_21790 ENOG4105CPD ethanolamine ammonia-lyase FEE38_21800 ENOG4106D67 ethanolamine utilization protein FEE38_21805 ENOG4108X49 Ethanolamine utilization protein EutK FEE38_21810 ENOG4108K3Z AraC family transcriptional regulator FEE38_21815 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FEE38_21820 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase FEE38_21825 ENOG4108R6G acetyltransferase FEE38_21830 ENOG4105QZU Inner membrane protein YfeZ FEE38_21835 ENOG4105E7K (LipO)protein FEE38_21840 ENOG4105EZR dyp-type peroxidase family protein FEE38_21850 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein FEE38_21855 ENOG4108I5D sulfate abc transporter FEE38_21860 ENOG4105ECW sulfate abc transporter FEE38_21865 ENOG4108IJ6 ABC transporter FEE38_21870 ENOG4105C6T cysteine synthase FEE38_21875 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein FEE38_21880 ENOG4105CSW GntR family transcriptional regulator FEE38_21885 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) FEE38_21895 ENOG4105C5Y PTS System FEE38_21900 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FEE38_21905 ENOG4105KZ7 phosphocarrier protein hpr FEE38_21910 ENOG4105C6T cysteine synthase FEE38_21915 ENOG4105EXN Sulfate transport protein CysZ FEE38_21920 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) FEE38_21925 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FEE38_21930 ENOG4105VRT cytoplasmic protein FEE38_21935 ENOG4105DHU Bile acid FEE38_21940 ENOG4108M0I Transcriptional regulator FEE38_21965 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FEE38_21970 ENOG4105GXM Putative transcription regulator (DUF1323) FEE38_21975 ENOG4105HZG regulatoR FEE38_21990 ENOG4108KMM Diguanylate cyclase FEE38_21995 ENOG4105D9N nucleoside FEE38_22000 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FEE38_22005 ENOG4109076 Conserved Protein FEE38_22010 ENOG4105CPC Aldo Keto reductase FEE38_22015 ENOG4107RA9 decarboxylase FEE38_22025 ENOG4105CHC glucokinase (EC 2.7.1.2) FEE38_22030 ENOG4105DY9 regulatoR FEE38_22035 ENOG4108HRK Histidine kinase FEE38_22045 ENOG4105CHM Aminotransferase FEE38_22055 ENOG4105DJ2 Major Facilitator Superfamily FEE38_22060 ENOG4107Y2X deaminase FEE38_22065 ENOG4105DND Transcriptional regulator FEE38_22085 ENOG4105F2I Transposase FEE38_22165 ENOG4105S64 Formate nitrite transporter FEE38_22170 ENOG410903C (LipO)protein FEE38_22175 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FEE38_22180 ENOG4105KZW UPF0381 protein FEE38_22185 ENOG4105CHU acetyl-coa acetyltransferase FEE38_22190 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FEE38_22195 ENOG4108BY2 phosphohistidine phosphatase FEE38_22200 ENOG4108DG9 Smr protein MutS2 FEE38_22205 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FEE38_22210 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FEE38_22215 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) FEE38_22220 ENOG4105EJ9 Membrane FEE38_22225 ENOG4108BPE -transporting atpase FEE38_22230 ENOG4105MH2 YfcL protein FEE38_22235 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FEE38_22240 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FEE38_22245 ENOG4105F9N Major Facilitator Superfamily FEE38_22250 ENOG4106WZ1 flagella biosynthesis regulator FEE38_22260 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FEE38_22265 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FEE38_22270 ENOG4105DQR SNARE associated Golgi FEE38_22275 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FEE38_22280 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FEE38_22285 ENOG4108S3P Sporulation domain protein FEE38_22290 ENOG4105E96 Colicin v production protein FEE38_22295 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FEE38_22300 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FEE38_22305 ENOG4105E89 ABC transporter FEE38_22310 ENOG4105E89 ABC transporter FEE38_22315 ENOG4105DSP amino acid AbC transporter FEE38_22320 ENOG4106YG3 ABC transporter FEE38_22325 ENOG4108JEH abc transporter atp-binding protein FEE38_22330 ENOG4105KNA -acetyltransferase FEE38_22335 ENOG4105ECP epimerase FEE38_22340 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase FEE38_22345 ENOG4105CYM Glutathione S-transferase FEE38_22350 ENOG4108SHQ Glutathione S-transferase FEE38_22355 ENOG4108RE9 Phosphodiesterase FEE38_22360 ENOG4105PTV Nudix Hydrolase FEE38_22365 ENOG4105C6K Malic enzyme FEE38_22370 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FEE38_22375 ENOG4105PQ6 UPF0208 membrane protein FEE38_22385 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FEE38_22390 ENOG4107QWE )-transporter FEE38_22395 ENOG4105DK2 UPF0207 protein FEE38_22400 ENOG4105CHM Aminotransferase FEE38_22405 ENOG4107NQ8 LysR family Transcriptional regulator FEE38_22415 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FEE38_22420 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FEE38_22425 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FEE38_22430 ENOG4105GKE subunit e FEE38_22435 ENOG4107QIZ NADH dehydrogenase FEE38_22440 ENOG4108IEH NADH dehydrogenase subunit g FEE38_22445 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FEE38_22455 ENOG4107UFS subunit j FEE38_22460 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FEE38_22465 ENOG4105D65 subunit l FEE38_22470 ENOG4105C8S subunit m FEE38_22475 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FEE38_22480 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FEE38_22485 ENOG4107YB6 acetyltransferase, (GNAT) family FEE38_22490 ENOG4105E4F Isochorismate synthase FEE38_22495 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FEE38_22500 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FEE38_22505 ENOG4108IPT Naphthoate synthase FEE38_22510 ENOG4105DNI Converts SHCHC to OSB (By similarity) FEE38_22515 ENOG4105CEY Amp-dependent synthetase and ligase FEE38_22525 ENOG4105DNE Transposase FEE38_22530 ENOG4108UII YfaZ family FEE38_22535 ENOG4108EWA cinA-like protein FEE38_22540 ENOG4107258 Transcriptional regulator FEE38_22545 ENOG4105CXK mandelate racemase muconate lactonizing FEE38_22550 ENOG4105CSP Major Facilitator Superfamily FEE38_22555 ENOG4105CNV Aldolase FEE38_22560 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FEE38_22565 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FEE38_22570 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A FEE38_22575 ENOG4105CXY transporter FEE38_22580 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FEE38_22585 ENOG4105XPH Ferredoxin FEE38_22590 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FEE38_22595 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FEE38_22600 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FEE38_22605 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FEE38_22610 ENOG4105BZU Histidine kinase FEE38_22615 ENOG41068CG regulatoR FEE38_22620 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC FEE38_22640 ENOG4105CF1 Alkylated DNA repair protein FEE38_22645 ENOG4105IBP Cyclic peptide transporter FEE38_22650 ENOG4105CJW magnesium transporter FEE38_22655 ENOG4105CHH sulfate transporter FEE38_22670 ENOG4105F4G Membrane FEE38_22680 ENOG4105E68 Sulfatase FEE38_22685 ENOG4105PAN UPF0352 protein FEE38_22690 ENOG4106V8H Nucleoid-associated protein FEE38_22695 ENOG4105N2W Transcriptional regulator FEE38_22700 ENOG4107VIJ nudix hydrolase FEE38_22715 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FEE38_22720 ENOG4105CFI type iii restriction protein res subunit FEE38_22725 ENOG4105I08 Pseudouridine synthase FEE38_22730 ENOG4105C2C drug resistance transporter, Bcr CflA FEE38_22735 ENOG4105HG6 FEE38_22740 ENOG4108JQ5 ABC transporter FEE38_22745 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FEE38_22750 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FEE38_22755 ENOG4105E43 Extracellular solute-binding protein, family 5 FEE38_22760 ENOG4105CXC rtn protein FEE38_22765 ENOG4107TT5 NLP P60 protein FEE38_22770 ENOG41076MN Phosphoesterase, PA-phosphatase related FEE38_22775 ENOG4105CKI cobalamin synthesis protein FEE38_22780 ENOG4105DEI Mannitol dehydrogenase FEE38_22785 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FEE38_22795 ENOG4105KRS Proteinase inhibitor FEE38_22800 ENOG4105S8Q sugar efflux transporter FEE38_22805 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FEE38_22810 ENOG4105DE4 1-phosphofructokinase FEE38_22815 ENOG4105DM4 PTS System FEE38_22820 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FEE38_22825 ENOG4105HMI Membrane FEE38_22830 ENOG4105DUM transcriptional regulator, lysR family FEE38_22835 ENOG4108IQI permease FEE38_22850 ENOG4105EUJ GTP cyclohydrolase i FEE38_22855 ENOG4105DHF Membrane FEE38_22860 ENOG41060NJ transcriptional regulator FEE38_22870 ENOG4105C2J ABC transporter FEE38_22875 ENOG4107SDZ Galactoside transport system permease protein mglC FEE38_22880 ENOG4107GZ4 SanA protein FEE38_22885 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) FEE38_22890 ENOG41067MG lrgb family FEE38_22895 ENOG4105VAW lrga family FEE38_22900 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FEE38_22905 ENOG4105TW1 Carbohydrate-selective porin OprB FEE38_22920 ENOG4105CS2 ec 3.2.1.21 FEE38_22935 ENOG4105KHU inner membrane protein YohD FEE38_22940 ENOG41069YE inner membrane protein yohC FEE38_22945 ENOG41061WM D-Alanyl-D-Alanine FEE38_22955 ENOG4105CXG d-lactate dehydrogenase FEE38_22960 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FEE38_22965 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system FEE38_22970 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component FEE38_22975 ENOG4108IJ8 ABC transporter FEE38_22980 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component FEE38_22990 ENOG4108HRK Histidine kinase FEE38_22995 ENOG4108NEV two component transcriptional regulator, LytTR family FEE38_23000 ENOG4108W15 Protein of unknown function (DUF1456) FEE38_23005 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FEE38_23010 ENOG4105D1F ATP-binding protein FEE38_23020 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly FEE38_23025 ENOG4105EJC lysr family transcriptional regulator FEE38_23030 ENOG4105C7N Xanthine uracil vitamin C permease FEE38_23035 ENOG4105CPN adenine deaminase FEE38_23040 ENOG4105DUM transcriptional regulator, lysR family FEE38_23055 ENOG4105DWF phosphomethylpyrimidine kinase FEE38_23060 ENOG4105FDP GntR family transcriptional regulator FEE38_23065 ENOG4108TFM Kinase, PfkB family FEE38_23070 ENOG4108KD5 ADP-ribosylation crystallin J1 FEE38_23075 ENOG4105EAA nucleoside FEE38_23080 ENOG4105EIE fructose-bisphosphate aldolase FEE38_23095 ENOG4105CFP Peptidase U32 FEE38_23100 ENOG4105E3W Two component transcriptional regulator (Winged helix family FEE38_23105 ENOG4105EB3 Histidine kinase FEE38_23115 ENOG4105BZS acriflavin resistance protein FEE38_23125 ENOG4105ENT Efflux transporter rnd family, mfp subunit FEE38_23130 ENOG4105CK2 sodium dicarboxylate symporter FEE38_23155 ENOG4105R8A Heat shock protein FEE38_23160 ENOG4105D03 DNA-3-methyladenine glycosylase II FEE38_23165 ENOG4105DBI uridine monophosphokinase FEE38_23170 ENOG4105DHP deoxycytidine triphosphate deaminase FEE38_23175 ENOG4108GAE asmA family FEE38_23180 ENOG4105EE5 Membrane protein terC FEE38_23190 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FEE38_23195 ENOG4105MH5 phosphoesterase PA-phosphatase related protein FEE38_23200 ENOG4108MRJ FEE38_23205 ENOG4105DAY polysaccharide export protein FEE38_23220 ENOG4105D3Q Sugar transferase FEE38_23225 ENOG4105CPK Glycosyl transferase (Group 1 FEE38_23230 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FEE38_23245 ENOG4105CGN Glycosyl transferase (Group 1 FEE38_23270 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FEE38_23325 ENOG4105CPK Glycosyl transferase (Group 1 FEE38_23350 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FEE38_23355 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FEE38_23365 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FEE38_23370 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FEE38_23375 ENOG4105CIH Imidazole acetol-phosphate transaminase FEE38_23385 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FEE38_23395 ENOG4107SRH Nad-dependent epimerase dehydratase FEE38_23400 ENOG4105EQ1 Transcriptional regulator FEE38_23410 ENOG4105CUB amino acid FEE38_23415 ENOG4105YVS arsR family transcriptional regulator FEE38_23420 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FEE38_23430 ENOG4105CJB Exodeoxyribonuclease I FEE38_23435 ENOG4105DZ1 carboxypeptidase FEE38_23445 ENOG4105DR8 Membrane FEE38_23450 ENOG41090HJ UPF0265 protein FEE38_23455 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FEE38_23460 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FEE38_23465 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FEE38_23475 ENOG41090U3 tautomerase FEE38_23480 ENOG4105HEI LysR family (Transcriptional regulator FEE38_23485 ENOG4108KMH lipoate-protein ligase a FEE38_23490 ENOG4105CSH Transporter FEE38_23505 ENOG4105BZU Histidine kinase FEE38_23515 ENOG4108YS1 cytoplasmic protein FEE38_23520 ENOG4105YP6 Domain of unknown function (DUF1869) FEE38_23525 ENOG4105ETT transcriptional Regulator, LysR family FEE38_23540 ENOG4105BZU Histidine kinase FEE38_23560 ENOG4105UQX Mate efflux family protein FEE38_23570 ENOG4105FYV Amp nucleosidase FEE38_23590 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FEE38_23595 ENOG4108WUH Transcriptional regulator, TetR family FEE38_23600 ENOG4105EEQ Na H antiporter FEE38_23615 ENOG4107R11 Transcriptional regulator FEE38_23620 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FEE38_23640 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) FEE38_23740 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) FEE38_23745 ENOG4108MXB Protein of unknown function (DUF968) FEE38_23770 ENOG4105NVB glycoside hydrolase, family 19 FEE38_23815 ENOG4105CAR Terminase, large subunit FEE38_23825 ENOG4105EFC phage portal protein HK97 family FEE38_23880 ENOG41064PC FEE38_23930 ENOG4105EKQ RNA-directed DNA polymerase FEE38_23945 ENOG4105FCK Membrane FEE38_23955 ENOG4105Y0K Inner membrane protein YedR FEE38_23960 ENOG4105EST Metal Dependent Phosphohydrolase FEE38_23965 ENOG4105DVF Cytosine-specific methyltransferase FEE38_23970 ENOG41090BB DNA mismatch endonuclease (vsr) FEE38_23975 ENOG4105FDR Membrane FEE38_23980 ENOG4105CKW Inner membrane protein yedI FEE38_23990 ENOG4105YX3 cellular response to acidity FEE38_24005 ENOG4105JCU Inherit from NOG: (Lipo)protein FEE38_24010 ENOG4105E5K Alpha-amylase FEE38_24015 ENOG4105EAB amino acid AbC transporter FEE38_24020 ENOG4105K6H D-cysteine desulfhydrase FEE38_24025 ENOG4105E5Q amino acid AbC transporter FEE38_24030 ENOG4105CDA abc transporter atp-binding protein FEE38_24035 ENOG4105VJY transcriptional regulator FEE38_24040 ENOG4105XVG cytoplasmic protein FEE38_24045 ENOG4105WH1 Two component transcriptional regulator luxr family FEE38_24080 ENOG4106RHG Yeca family FEE38_24085 ENOG4105E0U tyrosine-specific transport protein FEE38_24090 ENOG4105VVZ metal-binding protein FEE38_24095 ENOG41090A1 ferritin FEE38_24110 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEE38_24115 ENOG4105N4N Protein of unknown function (DUF2766) FEE38_24130 ENOG4108UEC Ferritin-like protein FEE38_24140 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator FEE38_24150 ENOG4105CNN ABC, transporter FEE38_24160 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase FEE38_24165 ENOG4108VA4 Universal stress protein FEE38_24170 ENOG4105CT4 transporter FEE38_24175 ENOG4105F5H Glycosyl Hydrolase Family 88 FEE38_24180 ENOG4105C75 arginyL-tRNA synthetase FEE38_24185 ENOG4106ZCM YecM protein FEE38_24190 ENOG4106N3A copper homeostasis protein cutc FEE38_24195 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FEE38_24200 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) FEE38_24205 ENOG4105WJG Glutathione FEE38_24210 ENOG41081XQ Conserved Protein FEE38_24215 ENOG4107R08 Integrase FEE38_24375 ENOG4105NVB glycoside hydrolase, family 19 FEE38_24420 ENOG4105CAR Terminase, large subunit FEE38_24430 ENOG4105EFC phage portal protein HK97 family FEE38_24530 ENOG4105D3W isochorismatase FEE38_24535 ENOG4105C9M aspartyl-trna synthetase FEE38_24540 ENOG4108TIT dATP pyrophosphohydrolase FEE38_24545 ENOG4105CDY transcriptional regulatory protein FEE38_24550 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FEE38_24555 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FEE38_24560 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FEE38_24565 ENOG4105FAV ABC, transporter FEE38_24575 ENOG4105NXV High-affinity zinc uptake system protein FEE38_24580 ENOG4105DR5 peptidase FEE38_24585 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FEE38_24590 ENOG4105CA9 Pyruvate kinase FEE38_24595 ENOG4106KNT transcriptional regulator FEE38_24610 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FEE38_24615 ENOG4105C01 Dihydroxy-acid dehydratase FEE38_24620 ENOG4108UHU Aldolase FEE38_24630 ENOG4105X2V dna damage-inducible protein FEE38_24635 ENOG4108Q2J Inner membrane protein YebE FEE38_24640 ENOG4105CUG Oligopeptidase b FEE38_24645 ENOG4105UMD exodeoxyribonuclease X FEE38_24650 ENOG4105MPK DNA polymerase III subunit theta FEE38_24655 ENOG4105FXM Copper resistance protein FEE38_24660 ENOG4108PNC copper resistance FEE38_24665 ENOG4105NKT exported protein FEE38_24675 ENOG4108MJ5 VirK protein FEE38_24680 ENOG4108R1E Serine threonine protein phosphatase 1 FEE38_24685 ENOG4105UVW uncharacterized protein yebW FEE38_24690 ENOG4105WT8 Protein of unknown function (DUF1480) FEE38_24695 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FEE38_24700 ENOG4105DY2 Paraquat-inducible protein b FEE38_24705 ENOG4105H2K paraquat-inducible protein a FEE38_24710 ENOG4108ZGC gaf domain protein FEE38_24715 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) FEE38_24720 ENOG4105CN1 protease FEE38_24725 ENOG4105D0M Protease HtpX homolog FEE38_24730 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEE38_24735 ENOG4105J4Q Transcriptional regulator FEE38_24740 ENOG4105TIK FEE38_24750 ENOG4105Q3Y exported protein FEE38_24775 ENOG4105CJN penicillin-binding protein FEE38_24780 ENOG4105DHI Methyltransferase FEE38_24785 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) FEE38_24790 ENOG4108NK4 UPF0266 membrane protein FEE38_24795 ENOG4105F3R pts system mannose fructose sorbose family iid FEE38_24800 ENOG4105ETZ PTS System FEE38_24805 ENOG4105DAS pts system FEE38_24810 ENOG4105EE5 Membrane protein terC FEE38_24815 ENOG4107XTP (EAL) domain protein FEE38_24820 ENOG4105EJQ L-serine dehydratase FEE38_24825 ENOG4105P8F nudix hydrolase FEE38_24835 ENOG4105X5C UPF0181 protein FEE38_24840 ENOG4105M4H endoribonuclease L-psp FEE38_24845 ENOG4105DVT helicase FEE38_24850 ENOG41072GX Peptidase M22 Glycoprotease FEE38_24855 ENOG4105Y4Z Outer Membrane Lipoprotein FEE38_24860 ENOG4105CEY Amp-dependent synthetase and ligase FEE38_24865 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FEE38_24870 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) FEE38_24875 ENOG4107QMS site-determining protein FEE38_24880 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FEE38_24885 ENOG4105VNG YcgL domain-containing protein FEE38_24890 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FEE38_24895 ENOG4108ZZ3 UPF0260 protein FEE38_24905 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FEE38_24910 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FEE38_24915 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) FEE38_24920 ENOG4105ED1 spovr family FEE38_24925 ENOG4105MWK D-amino acid dehydrogenase, small subunit FEE38_24935 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FEE38_24940 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FEE38_24945 ENOG4106JQ5 Transglycosylase SLT domain FEE38_24950 ENOG4105E0K tonB-dependent siderophore receptor FEE38_25005 ENOG410811B TRANSCRIPTIONal FEE38_25010 ENOG4105C7B Threonine dehydratase FEE38_25015 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) FEE38_25025 ENOG4105C6N Formate acetyltransferase FEE38_25035 ENOG4105C32 Amino acid ABC transporter (Permease) FEE38_25040 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FEE38_25045 ENOG4105C0Z ABC transporter FEE38_25050 ENOG4108IV0 ABC, transporter FEE38_25055 ENOG4107YNJ LysR family Transcriptional regulator FEE38_25075 ENOG4105CSH Transporter FEE38_25085 ENOG4105F04 LysR family Transcriptional regulator FEE38_25090 ENOG4107R08 Integrase FEE38_25185 ENOG4106CVF DNA replication protein FEE38_25190 ENOG4105CDU Replicative dna helicase FEE38_25195 ENOG4105QBX endodeoxyribonuclease RusA FEE38_25200 ENOG4105HGD Antitermination protein FEE38_25220 ENOG4105E5H Transposase FEE38_25225 ENOG4108YXQ IS66 Orf2 family protein FEE38_25335 ENOG4108C33 Resolvase FEE38_25350 ENOG4105D3G Pseudouridine synthase FEE38_25355 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FEE38_25385 ENOG4108ZG0 Ompa motb domain protein FEE38_25395 ENOG4105CS6 Rhs element vgr protein FEE38_25490 ENOG4105C3G gtp-binding protein FEE38_25495 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FEE38_25500 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria FEE38_25510 ENOG4105CHH sulfate transporter FEE38_25515 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FEE38_25520 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FEE38_25530 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FEE38_25535 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FEE38_25540 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FEE38_25545 ENOG4108YY7 Invasion gene expression up-regulator SirB FEE38_25550 ENOG41063JG Transcriptional regulator FEE38_25555 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FEE38_25560 ENOG4105EWV Sodium calcium exchanger membrane region FEE38_25565 ENOG4105WS7 Cation transport regulator FEE38_25570 ENOG4108NH8 Cation transport protein FEE38_25580 ENOG41090EX DsrE family FEE38_25590 ENOG4105I5W Transporter FEE38_25600 ENOG4105D7T ABC transporter FEE38_25605 ENOG4107QZF nitrite reductase NADPH large subunit FEE38_25615 ENOG4105ID0 Putative invasin FEE38_25620 ENOG4105WH1 Two component transcriptional regulator luxr family FEE38_25625 ENOG4105BZU Histidine kinase FEE38_25630 ENOG4105DQQ Major facilitator superfamily MFS_1 FEE38_25635 ENOG4105CRU nitrate reductase, alpha subunit FEE38_25640 ENOG4108IUE nitrate reductase beta subunit FEE38_25645 ENOG4105R3A Nitrate reductase FEE38_25650 ENOG41076YT nitrate reductase, gamma subunit FEE38_25695 ENOG4105CIY formyltetrahydrofolate deformylase FEE38_25705 ENOG4105D78 K07001 NTE family protein FEE38_25710 ENOG4105I93 response regulator FEE38_25715 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FEE38_25725 ENOG4107104 thymidine kinase FEE38_25730 ENOG4105C0A alcohol dehydrogenase FEE38_25740 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FEE38_25745 ENOG4108J59 Extracellular solute-binding protein, family 5 FEE38_25750 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FEE38_25755 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FEE38_25760 ENOG4105C3U ABC transporter FEE38_25765 ENOG4108JQ7 (ABC) transporter FEE38_25770 ENOG4105EYW Ion transport protein FEE38_25775 ENOG4108W5H UPF0263 protein FEE38_25780 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FEE38_25790 ENOG4108YYC ycei family FEE38_25800 ENOG4105K9H YciI-like protein FEE38_25805 ENOG410822N TonB family FEE38_25815 ENOG4105P10 Uncharacterized protein ydiZ FEE38_25820 ENOG4105DE4 1-phosphofructokinase FEE38_25825 ENOG4108NE3 Salt-induced outer membrane protein FEE38_25840 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FEE38_25845 ENOG41082NX 50s ribosomal protein l35 FEE38_25865 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FEE38_25870 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FEE38_25875 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FEE38_25885 ENOG4105MWK D-amino acid dehydrogenase, small subunit FEE38_25890 ENOG4105RQF LysR family Transcriptional regulator FEE38_25900 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) FEE38_25905 ENOG4105D01 (LipO)protein FEE38_25910 ENOG4108V06 Glutathione peroxidase FEE38_25920 ENOG4108QBX (LipO)protein FEE38_25925 ENOG4105CNG UPF0061 protein FEE38_25935 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FEE38_25945 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FEE38_25955 ENOG4105IPI Membrane FEE38_25960 ENOG4105CQB FAD linked oxidase domain protein FEE38_25965 ENOG4105KA0 thioesterase Superfamily protein FEE38_25970 ENOG4105Y3U Transglycosylase-associated protein FEE38_25990 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FEE38_26000 ENOG4105E0A ABC, transporter FEE38_26005 ENOG4105EHG Permease protein FEE38_26015 ENOG4106KR7 LysR family Transcriptional regulator FEE38_26040 ENOG4105DMF Dehydrogenase FEE38_26045 ENOG4105KBX Transcriptional regulator, TetR family FEE38_26060 ENOG4108Z4V iron-sulfur cluster assembly FEE38_26065 ENOG4105DIW FeS assembly protein SUFB FEE38_26070 ENOG4105C3K feS assembly ATPase SufC FEE38_26075 ENOG4105JRK feS assembly protein SufD FEE38_26080 ENOG4105C9B Cysteine desulfurase FEE38_26085 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FEE38_26090 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FEE38_26100 ENOG4105CA9 Pyruvate kinase FEE38_26110 ENOG4105RFR Protein of unknown function (DUF2767) FEE38_26125 ENOG4105DJB Major Facilitator Superfamily FEE38_26130 ENOG4105E2X shikimate dehydrogenase FEE38_26135 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein FEE38_26140 ENOG4108W0P ABC transporter FEE38_26145 ENOG4105EHG Permease protein FEE38_26150 ENOG4105S10 periplasmic binding protein FEE38_26155 ENOG4108K2P TRANSCRIPTIONal FEE38_26160 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase FEE38_26165 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) FEE38_26170 ENOG4107UB2 Alpha beta hydrolase fold FEE38_26175 ENOG4105IKQ hydratase FEE38_26180 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) FEE38_26185 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) FEE38_26190 ENOG4108SC4 )-transporter FEE38_26205 ENOG4108T2C cysteine dioxygenase type I FEE38_26210 ENOG4106KR7 LysR family Transcriptional regulator FEE38_26215 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FEE38_26235 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FEE38_26240 ENOG4108IY8 ABC, transporter FEE38_26250 ENOG4105E0A ABC, transporter FEE38_26255 ENOG4105DQ5 transport system permease protein FEE38_26275 ENOG4106PMH Extracellular solute-binding protein family 3 FEE38_26280 ENOG4105E5Q amino acid AbC transporter FEE38_26285 ENOG4105CDA abc transporter atp-binding protein FEE38_26290 ENOG4105KZM cytoplasmic protein FEE38_26300 ENOG41083G8 Multidrug resistance protein MdtM FEE38_26315 ENOG4105CH2 amidohydrolase FEE38_26320 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FEE38_26325 ENOG4105DG4 malate L-lactate dehydrogenase FEE38_26335 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC FEE38_26340 ENOG4107Z33 ABC transporter, permease FEE38_26355 ENOG4105GMB type VI secretion system effector, hcp1 family FEE38_26385 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) FEE38_26390 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FEE38_26395 ENOG41060IM Heme exporter protein FEE38_26405 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) FEE38_26410 ENOG4105DA4 cytochrome c-type biogenesis protein FEE38_26415 ENOG4107QX9 Thiol disulfide interChange protein FEE38_26420 ENOG4105KWW Biogenesis protein FEE38_26425 ENOG4108M1T Cytochrome c-type biogenesis protein FEE38_26440 ENOG41062D9 Histidine kinase FEE38_26445 ENOG4105E3W Two component transcriptional regulator (Winged helix family FEE38_26460 ENOG4105BZS acriflavin resistance protein FEE38_26475 ENOG4105CHR reductase FEE38_26480 ENOG4105C7K acetolactate synthase FEE38_26495 ENOG4105DTD Dehydrogenase FEE38_26500 ENOG4105CY2 Citrate transporter FEE38_26505 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FEE38_26510 ENOG4105CHU acetyl-coa acetyltransferase FEE38_26515 ENOG4107QNJ CoA-transferase subunit B FEE38_26525 ENOG4106NZI LysR family Transcriptional regulator FEE38_26555 ENOG4105DXI Major Facilitator superfamily FEE38_26570 ENOG4105CQB FAD linked oxidase domain protein FEE38_26575 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FEE38_26595 ENOG4105KME endoribonuclease L-psp FEE38_26600 ENOG4107TTD cytosine deaminase FEE38_26610 ENOG4105EMY transcriptional regulator FEE38_26655 ENOG4108JQ7 (ABC) transporter FEE38_26660 ENOG4105C3U ABC transporter FEE38_26685 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FEE38_26690 ENOG4105E98 transcriptional regulator DeoR family FEE38_26700 ENOG4107B2H carbonic anhydrase FEE38_26720 ENOG4105CY0 Metallo-Beta-Lactamase FEE38_26740 ENOG4105E1F short-chain dehydrogenase reductase FEE38_26755 ENOG4105F2I Transposase FEE38_26775 ENOG4108URH decarboxylase FEE38_26785 ENOG4107QI1 Mate efflux family protein FEE38_26790 ENOG4108R6K riboflavin synthase, subunit alpha FEE38_26795 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FEE38_26800 ENOG4105CZQ inner membrane transport protein YdhC FEE38_26805 ENOG4105F52 Transcriptional regulator FEE38_26810 ENOG4105ETE Transcriptional regulator (LacI family FEE38_26820 ENOG4105F27 Major Facilitator FEE38_26825 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FEE38_26835 ENOG4105K4H Nlp p60 protein FEE38_26840 ENOG4105M2J Glutaredoxin FEE38_26845 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FEE38_26850 ENOG4108UYE Lactoylglutathione lyase FEE38_26855 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FEE38_26860 ENOG4108WUH Transcriptional regulator, TetR family FEE38_26865 ENOG4105XZD Fe-S protein FEE38_26870 ENOG4107RGM aldo keto reductase FEE38_26875 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FEE38_26880 ENOG4105DSW Fusaric acid resistance protein FEE38_26885 ENOG4105Y49 secretion protein, HlyD family FEE38_26900 ENOG4105BZU Histidine kinase FEE38_26905 ENOG4108XTF Outer Membrane Lipoprotein FEE38_26910 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FEE38_26915 ENOG410642K Lysozyme inhibitor FEE38_26920 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FEE38_26925 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FEE38_26930 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) FEE38_26935 ENOG4108K3A Glutathione S-transferase FEE38_26950 ENOG4105CSM endonuclease III FEE38_26960 ENOG4108UQQ Electron transport complex FEE38_26985 ENOG4105M9B inner membrane protein ydgK FEE38_26995 ENOG4105CS2 ec 3.2.1.21 FEE38_27005 ENOG4105D9R oxidoreductase FEE38_27010 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FEE38_27015 ENOG4105EQ0 Major Facilitator superfamily FEE38_27035 ENOG4105CPW cytochrome b561 FEE38_27055 ENOG4105DDW LysR family Transcriptional regulator FEE38_27060 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha FEE38_27065 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta FEE38_27070 ENOG4105E32 cytoplasmic protein FEE38_27075 ENOG4105EBR Carboxylesterase FEE38_27090 ENOG4108Z9I -acetyltransferase FEE38_27095 ENOG4107WE3 acetyltransferase YdcK FEE38_27100 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein FEE38_27105 ENOG41088CC tellurite resistance protein tehB FEE38_27110 ENOG4108KKZ (LipO)protein FEE38_27115 ENOG4108RNG Permease of the drug metabolite transporter FEE38_27120 ENOG4105UEI Transcriptional Regulator AraC Family FEE38_27125 ENOG4105DKK Benzoate FEE38_27130 ENOG4108JCI Transcriptional regulator FEE38_27140 ENOG4105CFP Peptidase U32 FEE38_27160 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FEE38_27165 ENOG4105C4M (Ubiquinol oxidase) subunit I FEE38_27170 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FEE38_27175 ENOG4107TYH extracellular solute-binding protein family 1 FEE38_27180 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FEE38_27185 ENOG4105D81 ABC transporter, permease FEE38_27190 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component FEE38_27195 ENOG4105C26 Dehydrogenase FEE38_27220 ENOG410654E Membrane FEE38_27225 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 FEE38_27235 ENOG4105DEF Extracellular solute-binding protein, family 5 FEE38_27240 ENOG4105R71 cytoplasmic protein FEE38_27245 ENOG4108T9Y Inner membrane protein ydcZ FEE38_27250 ENOG4108Z7F N-acetyltransferase FEE38_27260 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FEE38_27265 ENOG4105DU0 nucleoside hydrolase FEE38_27275 ENOG41065TG regulatoR FEE38_27280 ENOG4105CI2 imidazolone-5-propionate hydrolase FEE38_27285 ENOG4105CHB tonB-dependent Receptor FEE38_27290 ENOG4108NS2 receptor FEE38_27300 ENOG4105C85 amino acid FEE38_27305 ENOG4105EQ2 LysR family Transcriptional regulator FEE38_27315 ENOG4105DEN Luciferase family FEE38_27330 ENOG4105EAB amino acid AbC transporter FEE38_27340 ENOG4105DRP amino acid AbC transporter FEE38_27345 ENOG4105CDA abc transporter atp-binding protein FEE38_27355 ENOG4108N27 Glutathione S-transferase FEE38_27385 ENOG4105CT4 transporter FEE38_27400 ENOG4108MEJ flavin reductase domain protein FEE38_27405 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FEE38_27410 ENOG4105C4Y ABC transporter FEE38_27415 ENOG4105E0C molybdate abc transporter FEE38_27420 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FEE38_27430 ENOG4105D0D Nitrate reductase 2, gamma subunit FEE38_27435 ENOG4108NZN Respiratory nitrate reductase 2 delta chain FEE38_27440 ENOG4108IUE nitrate reductase beta subunit FEE38_27445 ENOG4105CRU nitrate reductase, alpha subunit FEE38_27450 ENOG4107QND Nitrite extrusion protein FEE38_27465 ENOG4107HP6 Transcriptional regulator FEE38_27470 ENOG4105DTQ mandelate racemase muconate lactonizing FEE38_27475 ENOG4105NN7 muconolactone delta-isomerase FEE38_27480 ENOG410626B catechol 1,2-dioxygenase FEE38_27490 ENOG4108UKV benzoate 1,2-dioxygenase FEE38_27515 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FEE38_27520 ENOG4108MG3 formate dehydrogenase FEE38_27535 ENOG4105CSR polyphosphate kinase 2 FEE38_27545 ENOG4105F27 Major Facilitator FEE38_27560 ENOG4108JQ6 ABC transporter FEE38_27565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FEE38_27580 ENOG4105DQ4 alcohol dehydrogenase FEE38_27650 ENOG4105D0M Protease HtpX homolog FEE38_27700 ENOG4105EKE dihydroorotase FEE38_27710 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FEE38_27715 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FEE38_27720 ENOG4107RGD Major Facilitator superfamily FEE38_27750 ENOG4105EYK Phosphatidylglycerophosphatase B FEE38_27780 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FEE38_27795 ENOG4106CQM replication FEE38_27850 ENOG4105DZR Type I site-specific deoxyribonuclease FEE38_27855 ENOG4106RHG Yeca family FEE38_27890 ENOG4107CBI conjugal transfer fertility inhibition protein FEE38_28120 ENOG4105W1Y Transcriptional regulator FEE38_28175 ENOG4108SER Transposase FEE38_28180 ENOG41074AV Hok/gef family FEE38_28190 ENOG4105K4U addiction module toxin, RelE StbE family FEE38_28250 ENOG4107Y80 Major Facilitator superfamily FEE38_28260 ENOG41061MD high-affinity nickel-transporter FEE38_28265 ENOG4108YDI single-species biofilm formation on inanimate substrate FEE38_28320 ENOG4105FEQ ParB domain protein nuclease FEE38_28350 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FEE38_28390 ENOG4105MPK DNA polymerase III subunit theta FEE38_28410 ENOG4106JQ7 FEE38_28415 ENOG41073YN Protein of unknown function (DUF1380) FEE38_28445 ENOG4105EKQ RNA-directed DNA polymerase FEE38_28565 ENOG4108T1W Fimbrial subunit type 3 FEE38_28595 ENOG4105F2I Transposase FEE38_28660 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A FEE38_28665 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FEE38_28710 ENOG410624V efflux system protein FEE38_28740 ENOG4105DR5 peptidase FEE38_28750 ENOG4105E3B Multicopper oxidase FEE38_28755 ENOG4105VR0 copper resistance FEE38_28760 ENOG4105JDN Copper resistance protein FEE38_28765 ENOG4108PG2 copper resistance FEE38_28770 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FEE38_28775 ENOG4105GR3 Histidine kinase FEE38_28805 ENOG4108YXQ IS66 Orf2 family protein FEE38_28810 ENOG4105E5H Transposase FEE38_28835 ENOG4105KF5 hemolysin expression-modulating protein FEE38_28865 ENOG4105D0M Protease HtpX homolog FEE38_28885 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FEE38_28890 ENOG4105VN1 Heat shock protein FEE38_28920 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) FEE38_28925 ENOG4108IV0 ABC, transporter FEE38_28930 ENOG4105C0Z ABC transporter FEE38_28935 ENOG4105CNN ABC, transporter FEE38_28940 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FEE38_28945 ENOG41083Z3 extracellular ligand-binding receptor FEE38_28950 ENOG4105BZU Histidine kinase FEE38_28955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FEE38_28975 ENOG4105EQR Transposase IS116 IS110 IS902 FEE38_28980 ENOG4105F2I Transposase FEE38_28990 ENOG4108JQ6 ABC transporter FEE38_29005 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FEE38_29010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FEE38_29035 ENOG4108SF5 RNA Polymerase FEE38_29040 ENOG4108S3W Anti-feci sigma factor, fecr FEE38_29045 ENOG4105GAV receptor FEE38_29050 ENOG4108HUF Transporter FEE38_29055 ENOG4105DQ5 transport system permease protein FEE38_29060 ENOG4108IHU transport system permease protein FEE38_29065 ENOG4105E0A ABC, transporter FEE38_29070 ENOG4108YXQ IS66 Orf2 family protein FEE38_29085 ENOG4105EQR Transposase IS116 IS110 IS902 FEE38_29090 ENOG4105ETE Transcriptional regulator (LacI family FEE38_29100 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FEE38_29105 ENOG4108UW5 maltose o-acetyltransferase FEE38_29110 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FEE38_29115 ENOG4107SEY Conserved Protein FEE38_29140 ENOG4105VN1 Heat shock protein