locus-tag	class	description
CO218_00005	COG0531	amino acid
CO218_00015	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CO218_00015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CO218_00035	COG2017	converts alpha-aldose to the beta-anomer
CO218_00040	COG1304	FMN binding
CO218_00065	COG1199	ATP-dependent helicase activity
CO218_00065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CO218_00080	COG0017	Asparaginyl-tRNA synthetase
CO218_00095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO218_00100	COG2011	ABC-type metal ion transport system permease component
CO218_00105	COG1464	Belongs to the NlpA lipoprotein family
CO218_00130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO218_00135	COG3331	DNA recombination
CO218_00140	COG4474	Belongs to the UPF0398 family
CO218_00145	COG3599	regulation of cell shape
CO218_00155	COG0116	Belongs to the methyltransferase superfamily
CO218_00160	COG1073	alpha beta
CO218_00215	COG3328	transposase activity
CO218_00250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO218_00265	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CO218_00270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CO218_00275	COG0564	pseudouridine synthase activity
CO218_00280	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CO218_00285	COG0505	Belongs to the CarA family
CO218_00290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CO218_00305	COG5646	InterPro IPR014922
CO218_00330	COG1131	(ABC) transporter
CO218_00335	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CO218_00340	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CO218_00350	COG1307	EDD domain protein, DegV family
CO218_00410	COG1113	amino acid transport
CO218_00440	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CO218_00470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO218_00485	COG2801	Transposase and inactivated derivatives
CO218_00515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO218_00520	COG1227	inorganic diphosphatase activity
CO218_00525	COG0583	DNA-binding transcription factor activity
CO218_00535	COG0187	DNA topoisomerase II activity
CO218_00540	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CO218_00550	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CO218_00555	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CO218_00560	COG4974	Belongs to the 'phage' integrase family
CO218_00565	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CO218_00570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CO218_00575	COG0758	DNA mediated transformation
CO218_00580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CO218_00585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CO218_00595	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CO218_00600	COG0583	DNA-binding transcription factor activity
CO218_00615	COG2814	Major facilitator Superfamily
CO218_00620	COG0793	Belongs to the peptidase S41A family
CO218_00620	COG3409	Peptidoglycan-binding domain 1 protein
CO218_00625	COG4479	Belongs to the UPF0346 family
CO218_00630	COG4698	Protein conserved in bacteria
CO218_00635	COG2755	lipolytic protein G-D-S-L family
CO218_00645	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CO218_00650	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CO218_00655	COG0488	(ABC) transporter
CO218_00665	COG0617	tRNA 3'-terminal CCA addition
CO218_00670	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CO218_00680	COG0457	Tetratricopeptide repeat
CO218_00695	COG1160	GTP binding
CO218_00700	COG0539	negative regulation of cytoplasmic translation
CO218_00705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CO218_00715	COG0514	ATP-dependent DNA helicase (RecQ)
CO218_00730	COG1187	pseudouridine synthase activity
CO218_00735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CO218_00740	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CO218_00750	COG4974	Belongs to the 'phage' integrase family
CO218_00755	COG2996	Protein conserved in bacteria
CO218_00775	COG2826	transposase and inactivated derivatives, IS30 family
CO218_00780	COG0205	6-phosphofructokinase activity
CO218_00785	COG0587	DNA-directed DNA polymerase activity
CO218_00795	COG0542	response to heat
CO218_00805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CO218_00810	COG2384	SAM-dependent methyltransferase
CO218_00835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CO218_00835	COG0574	Belongs to the PEP-utilizing enzyme family
CO218_00845	COG1846	Transcriptional regulator
CO218_00875	COG0477	Major facilitator Superfamily
CO218_00890	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO218_00895	COG1349	DNA-binding transcription factor activity
CO218_00940	COG0583	DNA-binding transcription factor activity
CO218_00945	COG0604	alcohol dehydrogenase
CO218_00955	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO218_00960	COG2197	response regulator
CO218_00965	COG4585	Histidine kinase
CO218_00975	COG1131	(ABC) transporter
CO218_00985	COG0519	Catalyzes the synthesis of GMP from XMP
CO218_01020	COG1131	(ABC) transporter
CO218_01025	COG1725	Transcriptional regulator
CO218_01035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO218_01040	COG0358	DNA primase activity
CO218_01045	COG0751	glycine-tRNA ligase activity
CO218_01050	COG0752	glycyl-tRNA synthetase alpha subunit
CO218_01055	COG1381	Involved in DNA repair and RecF pathway recombination
CO218_01060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CO218_01065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CO218_01070	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CO218_01075	COG1702	phosphate starvation-inducible protein PhoH
CO218_01080	COG1610	YqeY-like protein
CO218_01085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CO218_01090	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CO218_01100	COG3328	transposase activity
CO218_01105	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CO218_01115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO218_01125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CO218_01130	COG0124	histidyl-tRNA synthetase
CO218_01135	COG4991	sh3 domain protein
CO218_01135	COG3103	Sh3 type 3 domain protein
CO218_01135	COG0860	N-Acetylmuramoyl-L-alanine amidase
CO218_01140	COG3001	Fructosamine kinase
CO218_01145	COG0546	phosphoglycolate phosphatase activity
CO218_01150	COG1490	D-aminoacyl-tRNA deacylase activity
CO218_01155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CO218_01165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CO218_01170	COG2264	protein methyltransferase activity
CO218_01175	COG2094	Belongs to the DNA glycosylase MPG family
CO218_01190	COG0481	GTPase activity
CO218_01195	COG4372	Transposase
CO218_01210	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CO218_01215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO218_01220	COG1696	Membrane protein involved in D-alanine export
CO218_01235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CO218_01240	COG0484	heat shock protein binding
CO218_01245	COG0443	Heat shock 70 kDa protein
CO218_01250	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CO218_01255	COG1420	regulation of RNA biosynthetic process
CO218_01260	COG3527	Alpha-acetolactate decarboxylase
CO218_01265	COG0196	riboflavin kinase activity
CO218_01270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CO218_01275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CO218_01280	COG0287	Prephenate dehydrogenase
CO218_01285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CO218_01295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CO218_01300	COG0738	Major facilitator superfamily
CO218_01315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CO218_01320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CO218_01330	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CO218_01335	COG0195	Participates in both transcription termination and antitermination
CO218_01340	COG0779	Required for maturation of 30S ribosomal subunits
CO218_01345	COG2176	DNA-directed DNA polymerase activity
CO218_01350	COG0442	prolyl-tRNA aminoacylation
CO218_01355	COG0750	zinc metalloprotease
CO218_01360	COG4589	Belongs to the CDS family
CO218_01365	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CO218_01370	COG0233	cytoplasmic translational termination
CO218_01375	COG0528	UMP kinase activity
CO218_01380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CO218_01385	COG0052	Belongs to the universal ribosomal protein uS2 family
CO218_01395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO218_01400	COG2827	Endonuclease containing a URI domain
CO218_01405	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CO218_01410	COG0204	Acyl-transferase
CO218_01415	COG3763	UPF0154 protein
CO218_01420	COG4224	UPF0291 protein
CO218_01425	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CO218_01440	COG3425	synthase
CO218_01455	COG0463	Glycosyl transferase, family 2
CO218_01720	COG2176	DNA-directed DNA polymerase activity
CO218_01755	COG0393	Putative heavy-metal-binding
CO218_01770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO218_01775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CO218_01775	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CO218_01780	COG5416	Lipopolysaccharide assembly protein A domain
CO218_01785	COG0300	oxidoreductase activity
CO218_01790	COG1234	tRNA 3'-trailer cleavage
CO218_01800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CO218_01805	COG1349	DNA-binding transcription factor activity
CO218_01810	COG1105	Belongs to the carbohydrate kinase PfkB family
CO218_01815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO218_01815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO218_01815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO218_01820	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CO218_01845	COG0438	transferase activity, transferring glycosyl groups
CO218_01850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CO218_01865	COG0489	protein tyrosine kinase activity
CO218_01875	COG0322	excinuclease ABC activity
CO218_01880	COG1126	abc transporter atp-binding protein
CO218_01885	COG0765	amino acid transport
CO218_01905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CO218_01910	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CO218_01915	COG0544	peptidyl-prolyl cis-trans isomerase activity
CO218_01920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CO218_01945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CO218_01950	COG0268	Binds directly to 16S ribosomal RNA
CO218_01955	COG1466	dna polymerase III delta subunit
CO218_01965	COG2131	deaminase
CO218_01970	COG1555	photosystem II stabilization
CO218_01970	COG1596	polysaccharide export
CO218_01975	COG3480	Lon protease (S16) C-terminal proteolytic domain
CO218_01980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CO218_01985	COG0742	ribosomal rna small subunit methyltransferase
CO218_01990	COG4471	UPF0298 protein
CO218_01995	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CO218_02000	COG0772	Belongs to the SEDS family
CO218_02035	COG3328	transposase activity
CO218_02045	COG1217	gtp-binding protein TYPA
CO218_02050	COG0483	inositol monophosphate 1-phosphatase activity
CO218_02055	COG4476	Belongs to the UPF0223 family
CO218_02060	COG0039	L-malate dehydrogenase activity
CO218_02085	COG0242	peptide deformylase activity
CO218_02095	COG5503	Protein of unknown function (DUF1447)
CO218_02100	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CO218_02105	COG1597	lipid kinase activity
CO218_02115	COG3584	3D domain protein
CO218_02115	COG1388	LysM domain
CO218_02120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO218_02125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CO218_02160	COG0569	domain protein
CO218_02165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CO218_02170	COG0482	sulfurtransferase activity
CO218_02180	COG1104	cysteine desulfurase activity
CO218_02185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CO218_02195	COG0494	nUDIX hydrolase
CO218_02200	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CO218_02210	COG3279	Response regulator of the LytR AlgR family
CO218_02225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CO218_02230	COG3599	regulation of cell shape
CO218_02240	COG0762	integral membrane protein
CO218_02245	COG1799	cell septum assembly
CO218_02260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CO218_02265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CO218_02270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CO218_02275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CO218_02280	COG0768	penicillin binding
CO218_02290	COG0275	rRNA processing
CO218_02295	COG2001	Belongs to the MraZ family
CO218_02315	COG1674	ftsk spoiiie
CO218_02320	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CO218_02330	COG1114	Component of the transport system for branched-chain amino acids
CO218_02345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CO218_02350	COG0628	permease
CO218_02360	COG2706	6-phosphogluconolactonase activity
CO218_02365	COG3142	Participates in the control of copper homeostasis
CO218_02370	COG0564	pseudouridine synthase activity
CO218_02375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CO218_02380	COG2357	RelA SpoT domain protein
CO218_02390	COG1164	Oligoendopeptidase f
CO218_02400	COG4862	establishment of competence for transformation
CO218_02410	COG2826	transposase and inactivated derivatives, IS30 family
CO218_02415	COG1234	tRNA 3'-trailer cleavage
CO218_02555	COG1098	S1 RNA binding domain
CO218_02565	COG0586	Pfam SNARE associated Golgi protein
CO218_02575	COG0647	UMP catabolic process
CO218_02580	COG4470	Protein conserved in bacteria
CO218_02585	COG0737	Belongs to the 5'-nucleotidase family
CO218_02600	COG1113	amino acid transport
CO218_02605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CO218_02610	COG0827	DNA restriction-modification system
CO218_02640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CO218_02650	COG0217	transcriptional regulatory protein
CO218_02665	COG1609	Transcriptional regulator
CO218_02670	COG0006	proline dipeptidase activity
CO218_02675	COG0789	Transcriptional regulator
CO218_02690	COG0668	transmembrane transport
CO218_02695	COG2801	Transposase and inactivated derivatives
CO218_02705	COG1473	amidohydrolase
CO218_02710	COG2171	N-acyltransferase activity
CO218_02715	COG0517	IMP dehydrogenase activity
CO218_02725	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CO218_02730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CO218_02735	COG1719	4-vinyl reductase, 4VR
CO218_02740	COG3118	belongs to the thioredoxin family
CO218_02745	COG1193	negative regulation of DNA recombination
CO218_02755	COG3906	Belongs to the UPF0473 family
CO218_02760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CO218_02765	COG4472	Bacterial protein of unknown function (DUF965)
CO218_02770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CO218_02775	COG0513	Belongs to the DEAD box helicase family
CO218_02780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CO218_02785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO218_02790	COG1862	Preprotein translocase
CO218_02795	COG0343	queuine tRNA-ribosyltransferase activity
CO218_02800	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CO218_02805	COG2255	four-way junction helicase activity
CO218_02810	COG0632	four-way junction helicase activity
CO218_02840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CO218_02845	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CO218_02850	COG1692	metallophosphoesterase
CO218_02855	COG1418	mRNA catabolic process
CO218_02860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CO218_02865	COG1546	Belongs to the CinA family
CO218_02865	COG1058	Belongs to the CinA family
CO218_02870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CO218_02875	COG1426	Protein conserved in bacteria
CO218_02880	COG0612	Peptidase, M16
CO218_02885	COG0612	Peptidase, M16
CO218_02890	COG0527	aspartate kinase activity
CO218_02900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO218_02905	COG1126	abc transporter atp-binding protein
CO218_02910	COG0765	amino acid transport
CO218_02915	COG2894	cell division
CO218_02920	COG0850	regulation of cytokinetic process
CO218_02930	COG1792	Involved in formation and maintenance of cell shape
CO218_02935	COG1077	Cell shape determining protein MreB Mrl
CO218_02945	COG0285	dihydrofolate synthase activity
CO218_02950	COG0525	valine-tRNA ligase activity
CO218_02960	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO218_02960	COG2918	glutathione biosynthetic process
CO218_02965	COG0301	tRNA thio-modification
CO218_02970	COG1104	cysteine desulfurase activity
CO218_02980	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CO218_02985	COG1956	GAF domain-containing protein
CO218_02990	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CO218_02995	COG4493	Belongs to the UPF0637 family
CO218_03010	COG0640	Transcriptional regulator
CO218_03015	COG0366	Alpha amylase catalytic
CO218_03025	COG3716	PTS system mannose fructose sorbose family IID component
CO218_03030	COG3715	PTS system
CO218_03035	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO218_03040	COG1609	Transcriptional regulator
CO218_03045	COG2918	glutathione biosynthetic process
CO218_03045	COG0189	ligase activity
CO218_03050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CO218_03065	COG0589	response to stress
CO218_03085	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO218_03105	COG1464	Belongs to the NlpA lipoprotein family
CO218_03110	COG2011	ABC-type metal ion transport system permease component
CO218_03115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO218_03120	COG0509	glycine decarboxylation via glycine cleavage system
CO218_03125	COG0772	Belongs to the SEDS family
CO218_03135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CO218_03140	COG1077	Cell shape determining protein MreB Mrl
CO218_03150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO218_03155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CO218_03160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CO218_03165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CO218_03170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CO218_03175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO218_03180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CO218_03185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO218_03190	COG0356	it plays a direct role in the translocation of protons across the membrane
CO218_03195	COG2233	PERMEase
CO218_03205	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CO218_03210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CO218_03215	COG0009	L-threonylcarbamoyladenylate synthase
CO218_03220	COG2890	protein-(glutamine-N5) methyltransferase activity
CO218_03225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CO218_03230	COG1435	thymidine kinase activity
CO218_03235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CO218_03240	COG3442	glutamine amidotransferase
CO218_03245	COG1482	cell wall glycoprotein biosynthetic process
CO218_03250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CO218_03260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO218_03270	COG2801	Transposase and inactivated derivatives
CO218_03285	COG1132	(ABC) transporter
CO218_03300	COG0726	polysaccharide deacetylase
CO218_03310	COG3177	Filamentation induced by cAMP protein fic
CO218_03440	COG1783	phage Terminase large subunit
CO218_03445	COG5484	DNA packaging
CO218_03445	COG3728	DNA packaging
CO218_03595	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CO218_03645	COG4695	Portal protein
CO218_03720	COG4974	Belongs to the 'phage' integrase family
CO218_03730	COG2801	Transposase and inactivated derivatives
CO218_03755	COG4932	domain protein
CO218_03755	COG4886	Leucine-rich repeat (LRR) protein
CO218_03795	COG1132	(ABC) transporter
CO218_03805	COG1136	(ABC) transporter
CO218_03805	COG0577	efflux transmembrane transporter activity
CO218_03815	COG0166	Belongs to the GPI family
CO218_03820	COG4975	Glucose uptake
CO218_03825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CO218_03830	COG5002	protein histidine kinase activity
CO218_03830	COG3850	Histidine kinase
CO218_03835	COG0745	RESPONSE REGULATOR receiver
CO218_03840	COG2848	UPF0210 protein
CO218_03845	COG3830	Belongs to the UPF0237 family
CO218_03905	COG0791	NLP P60 protein
CO218_03910	COG1522	sequence-specific DNA binding
CO218_03930	COG0488	(ABC) transporter
CO218_03960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO218_03960	COG2190	(PTS) system
CO218_03960	COG1263	PTS System
CO218_03965	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CO218_03975	COG1307	EDD domain protein, DegV family
CO218_03985	COG2873	o-acetylhomoserine
CO218_03990	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CO218_04005	COG4120	Belongs to the binding-protein-dependent transport system permease family
CO218_04015	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO218_04040	COG2084	Dehydrogenase
CO218_04045	COG0861	Integral membrane protein TerC family
CO218_04050	COG0110	maltose O-acetyltransferase activity
CO218_04060	COG0140	phosphoribosyl-ATP diphosphatase activity
CO218_04065	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CO218_04070	COG0107	imidazoleglycerol-phosphate synthase activity
CO218_04075	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CO218_04080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CO218_04085	COG0131	Imidazoleglycerol-phosphate dehydratase
CO218_04090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CO218_04100	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CO218_04105	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CO218_04130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CO218_04145	COG2801	Transposase and inactivated derivatives
CO218_04160	COG1368	sulfuric ester hydrolase activity
CO218_04165	COG0584	glycerophosphoryl diester phosphodiesterase
CO218_04175	COG0492	ferredoxin-NADP+ reductase activity
CO218_04185	COG4932	domain protein
CO218_04190	COG2326	polyphosphate kinase activity
CO218_04195	COG0778	Nitroreductase
CO218_04205	COG0328	RNA-DNA hybrid ribonuclease activity
CO218_04215	COG1609	Transcriptional regulator
CO218_04225	COG0673	inositol 2-dehydrogenase activity
CO218_04230	COG0673	inositol 2-dehydrogenase activity
CO218_04235	COG0025	NhaP-type Na H and K H
CO218_04245	COG1335	isochorismatase
CO218_04255	COG1131	(ABC) transporter
CO218_04260	COG1725	Transcriptional regulator
CO218_04300	COG0028	Belongs to the TPP enzyme family
CO218_04310	COG1073	alpha beta
CO218_04315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO218_04320	COG0626	cystathionine gamma-synthase activity
CO218_04350	COG0095	Lipoate-protein ligase
CO218_04355	COG1705	Flagellar rod assembly protein muramidase FlgJ
CO218_04365	COG0589	response to stress
CO218_04370	COG0564	pseudouridine synthase activity
CO218_04375	COG1396	sequence-specific DNA binding
CO218_04390	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CO218_04400	COG2188	Transcriptional regulator
CO218_04405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CO218_04415	COG1418	mRNA catabolic process
CO218_04445	COG1253	flavin adenine dinucleotide binding
CO218_04460	COG1780	Probably involved in ribonucleotide reductase function
CO218_04470	COG0025	NhaP-type Na H and K H
CO218_04475	COG2814	Major facilitator Superfamily
CO218_04480	COG3328	transposase activity
CO218_04485	COG0789	Transcriptional regulator
CO218_04490	COG0604	alcohol dehydrogenase
CO218_04500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CO218_04510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO218_04515	COG0436	Aminotransferase
CO218_04520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO218_04535	COG0583	DNA-binding transcription factor activity
CO218_04540	COG0702	epimerase
CO218_04550	COG1074	ATP-dependent DNA helicase activity
CO218_04555	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CO218_04565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CO218_04570	COG0284	orotidine-5'-phosphate decarboxylase activity
CO218_04575	COG0167	dihydroorotate dehydrogenase activity
CO218_04580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CO218_04585	COG0505	Belongs to the CarA family
CO218_04590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CO218_04595	COG0540	Belongs to the ATCase OTCase family
CO218_04600	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CO218_04605	COG2508	Transcriptional regulator
CO218_04610	COG2233	PERMEase
CO218_04615	COG2252	PERMEase
CO218_04645	COG0151	Belongs to the GarS family
CO218_04650	COG0138	bifunctional purine biosynthesis protein purh
CO218_04655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CO218_04660	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CO218_04670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO218_04675	COG0047	phosphoribosylformylglycinamidine synthase activity
CO218_04680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO218_04685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CO218_04690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CO218_04700	COG1053	succinate dehydrogenase
CO218_04700	COG0431	NADPH-dependent FMN reductase
CO218_04700	COG3976	FMN-binding domain protein
CO218_04705	COG3976	FMN-binding domain protein
CO218_04705	COG0431	NADPH-dependent FMN reductase
CO218_04705	COG1053	succinate dehydrogenase
CO218_04710	COG0095	Lipoate-protein ligase
CO218_04715	COG2365	Tyrosine phosphatase family
CO218_04735	COG1136	(ABC) transporter
CO218_04750	COG1725	Transcriptional regulator
CO218_04755	COG1131	(ABC) transporter
CO218_04765	COG0589	response to stress
CO218_04775	COG2246	polysaccharide biosynthetic process
CO218_04795	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CO218_04820	COG2801	Transposase and inactivated derivatives
CO218_04825	COG0366	Alpha amylase catalytic
CO218_04835	COG0561	phosphatase activity
CO218_04845	COG0110	maltose O-acetyltransferase activity
CO218_04850	COG0494	nUDIX hydrolase
CO218_04885	COG1827	regulation of RNA biosynthetic process
CO218_04890	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CO218_04895	COG1309	transcriptional regulator
CO218_04905	COG1131	(ABC) transporter
CO218_04910	COG3048	D-serine ammonia-lyase activity
CO218_04915	COG3328	transposase activity
CO218_04920	COG2723	6-phospho-beta-galactosidase activity
CO218_04925	COG2723	6-phospho-beta-galactosidase activity
CO218_04930	COG1447	Phosphotransferase system cellobiose-specific component IIA
CO218_04935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO218_04940	COG2188	Transcriptional regulator
CO218_04945	COG1216	Glycosyl transferase, family 2
CO218_04960	COG0561	phosphatase activity
CO218_04965	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CO218_04990	COG0716	FMN binding
CO218_05010	COG0710	3-dehydroquinate dehydratase activity
CO218_05015	COG0531	amino acid
CO218_05060	COG4720	Psort location CytoplasmicMembrane, score
CO218_05065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CO218_05080	COG4990	cell redox homeostasis
CO218_05100	COG1811	Na channel or pump
CO218_05110	COG4978	Transcriptional regulator
CO218_05110	COG0789	Transcriptional regulator
CO218_05125	COG0577	efflux transmembrane transporter activity
CO218_05130	COG1136	(ABC) transporter
CO218_05170	COG2814	Major facilitator Superfamily
CO218_05180	COG2814	Major facilitator Superfamily
CO218_05190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO218_05195	COG2855	membrane
CO218_05200	COG0583	DNA-binding transcription factor activity
CO218_05210	COG0438	transferase activity, transferring glycosyl groups
CO218_05225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CO218_05235	COG4152	abc transporter atp-binding protein
CO218_05245	COG4221	oxidoreductase activity
CO218_05260	COG0789	Transcriptional regulator
CO218_05265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CO218_05290	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CO218_05315	COG0456	acetyltransferase
CO218_05360	COG1063	alcohol dehydrogenase
CO218_05365	COG1028	Short-chain dehydrogenase reductase Sdr
CO218_05375	COG0589	response to stress
CO218_05380	COG0110	maltose O-acetyltransferase activity
CO218_05385	COG1011	Hydrolase
CO218_05415	COG3409	Peptidoglycan-binding domain 1 protein
CO218_05420	COG3328	transposase activity
CO218_05430	COG1131	(ABC) transporter
CO218_05490	COG0667	Aldo Keto reductase
CO218_05495	COG1132	(ABC) transporter
CO218_05500	COG1132	(ABC) transporter
CO218_05505	COG2814	Major facilitator Superfamily
CO218_05520	COG1511	domain protein
CO218_05520	COG1511	domain protein
CO218_05530	COG0640	Transcriptional regulator
CO218_05555	COG0488	(ABC) transporter
CO218_05570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CO218_05590	COG2270	Major facilitator Superfamily
CO218_05645	COG1328	CTP reductase activity
CO218_05655	COG0242	peptide deformylase activity
CO218_05665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CO218_05685	COG0583	DNA-binding transcription factor activity
CO218_05760	COG0697	spore germination
CO218_05785	COG1131	(ABC) transporter
CO218_05815	COG1940	carbohydrate kinase activity
CO218_05830	COG0778	Nitroreductase
CO218_05835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO218_05835	COG2190	(PTS) system
CO218_05835	COG1263	PTS System
CO218_05840	COG1116	anion transmembrane transporter activity
CO218_05845	COG4120	Belongs to the binding-protein-dependent transport system permease family
CO218_05875	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CO218_05875	COG0617	tRNA 3'-terminal CCA addition
CO218_05875	COG3620	sequence-specific DNA binding
CO218_05880	COG0410	ABC transporter
CO218_05890	COG3328	transposase activity
CO218_05900	COG0559	Belongs to the binding-protein-dependent transport system permease family
CO218_05915	COG5549	protein import
CO218_05915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CO218_05920	COG2246	polysaccharide biosynthetic process
CO218_05930	COG1914	H( )-stimulated, divalent metal cation uptake system
CO218_05950	COG0640	Transcriptional regulator
CO218_05970	COG0577	efflux transmembrane transporter activity
CO218_05970	COG1136	(ABC) transporter
CO218_06015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO218_06020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO218_06025	COG2723	6-phospho-beta-galactosidase activity
CO218_06035	COG0789	Transcriptional regulator
CO218_06040	COG0741	lytic transglycosylase activity
CO218_06065	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO218_06090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO218_06105	COG4221	oxidoreductase activity
CO218_06135	COG1028	Short-chain dehydrogenase reductase Sdr
CO218_06150	COG1132	(ABC) transporter
CO218_06165	COG1473	amidohydrolase
CO218_06170	COG1028	Short-chain dehydrogenase reductase Sdr
CO218_06180	COG3328	transposase activity
CO218_06190	COG0531	amino acid
CO218_06220	COG2217	Heavy metal translocating P-type atpase
CO218_06275	COG3328	transposase activity
CO218_06280	COG3775	system Galactitol-specific IIC component
CO218_06285	COG3414	Phosphotransferase system galactitol-specific IIB component
CO218_06320	COG2226	methyltransferase
CO218_06325	COG0588	phosphoglycerate mutase activity
CO218_06330	COG0628	permease
CO218_06335	COG1940	carbohydrate kinase activity
CO218_06335	COG1846	Transcriptional regulator
CO218_06345	COG2801	Transposase and inactivated derivatives
CO218_06355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CO218_06365	COG2815	serine threonine protein kinase
CO218_06365	COG0515	serine threonine protein kinase
CO218_06405	COG1247	-acetyltransferase
CO218_06410	COG1686	Belongs to the peptidase S11 family
CO218_06430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CO218_06435	COG0516	GMP reductase activity
CO218_06435	COG0517	IMP dehydrogenase activity
CO218_06445	COG0012	GTP binding
CO218_06450	COG4481	Protein conserved in bacteria
CO218_06455	COG1475	DNA binding
CO218_06460	COG1192	Involved in chromosome partitioning
CO218_06470	COG0357	Ribosomal RNA small subunit methyltransferase G
CO218_06475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CO218_06490	COG0583	DNA-binding transcription factor activity
CO218_06495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO218_06500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO218_06505	COG0765	amino acid transport
CO218_06510	COG1126	abc transporter atp-binding protein
CO218_06515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO218_06540	COG2190	(PTS) system
CO218_06540	COG1263	PTS System
CO218_06540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO218_06545	COG0366	Alpha amylase catalytic
CO218_06550	COG1609	Transcriptional regulator
CO218_06560	COG0390	transport system, permease component
CO218_06565	COG4619	ABC transporter
CO218_06570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO218_06585	COG0561	phosphatase activity
CO218_06630	COG0735	belongs to the Fur family
CO218_06655	COG1380	Effector of murein hydrolase LrgA
CO218_06665	COG1307	EDD domain protein, DegV family
CO218_06675	COG2738	Putative neutral zinc metallopeptidase
CO218_06685	COG1562	ergosterol biosynthetic process
CO218_06695	COG1929	Belongs to the glycerate kinase type-1 family
CO218_06710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CO218_06715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CO218_06720	COG0516	GMP reductase activity
CO218_06725	COG2365	Tyrosine phosphatase family
CO218_06730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CO218_06740	COG1511	domain protein
CO218_06755	COG3328	transposase activity
CO218_06765	COG0531	amino acid
CO218_06770	COG3158	transport of potassium into the cell
CO218_06775	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CO218_06780	COG0628	permease
CO218_06785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CO218_06800	COG1272	protein, Hemolysin III
CO218_06805	COG0640	Transcriptional regulator
CO218_06835	COG2801	Transposase and inactivated derivatives
CO218_06850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CO218_06860	COG0302	gtp cyclohydrolase
CO218_06865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CO218_06885	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO218_06920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CO218_06925	COG1882	Formate acetyltransferase
CO218_06930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CO218_06940	COG2151	metal-sulfur cluster biosynthetic enzyme
CO218_06945	COG4989	oxidoreductase activity
CO218_06975	COG2217	Heavy metal translocating P-type atpase
CO218_06985	COG2315	Protein conserved in bacteria
CO218_06995	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CO218_07000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CO218_07010	COG1757	Na H antiporter
CO218_07015	COG1113	amino acid transport
CO218_07030	COG2801	Transposase and inactivated derivatives
CO218_07040	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CO218_07060	COG1393	Belongs to the ArsC family
CO218_07065	COG3189	MarR family transcriptional regulator
CO218_07075	COG1194	a g-specific adenine glycosylase
CO218_07090	COG0071	Belongs to the small heat shock protein (HSP20) family
CO218_07115	COG0697	spore germination
CO218_07130	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CO218_07230	COG0737	Belongs to the 5'-nucleotidase family
CO218_07240	COG0656	L-ascorbic acid biosynthetic process
CO218_07260	COG1968	undecaprenyl-diphosphatase activity
CO218_07265	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CO218_07295	COG3328	transposase activity
CO218_07335	COG0076	glutamate decarboxylase activity
CO218_07365	COG3328	transposase activity
CO218_07395	COG1309	transcriptional regulator
CO218_07405	COG2226	methyltransferase
CO218_07435	COG2217	Heavy metal translocating P-type atpase
CO218_07440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO218_07445	COG3118	belongs to the thioredoxin family
CO218_07450	COG1937	Protein conserved in bacteria
CO218_07470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO218_07475	COG3590	peptidase
CO218_07500	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO218_07550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO218_07560	COG1114	Component of the transport system for branched-chain amino acids
CO218_07570	COG1874	Beta-galactosidase
CO218_07625	COG2826	transposase and inactivated derivatives, IS30 family
CO218_07650	COG2184	nucleotidyltransferase activity
CO218_07655	COG2944	sequence-specific DNA binding
CO218_07660	COG1609	Transcriptional regulator
CO218_07665	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CO218_07670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CO218_07675	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CO218_07695	COG2211	Major facilitator Superfamily
CO218_07695	COG2190	(PTS) system
CO218_07700	COG2017	converts alpha-aldose to the beta-anomer
CO218_07705	COG1609	Transcriptional regulator
CO218_07730	COG0710	3-dehydroquinate dehydratase activity
CO218_07735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CO218_07740	COG0583	DNA-binding transcription factor activity
CO218_07760	COG1028	Short-chain dehydrogenase reductase Sdr
CO218_07775	COG2271	Major facilitator Superfamily
CO218_07800	COG2801	Transposase and inactivated derivatives
CO218_07825	COG2261	transglycosylase associated protein
CO218_07835	COG1393	Belongs to the ArsC family
CO218_07855	COG4512	PFAM Accessory gene regulator B
CO218_07905	COG4975	Glucose uptake
CO218_07910	COG1869	D-ribose catabolic process
CO218_07920	COG1609	Transcriptional regulator
CO218_07925	COG1012	belongs to the aldehyde dehydrogenase family
CO218_07925	COG1454	alcohol dehydrogenase
CO218_07935	COG1695	Transcriptional regulator
CO218_07940	COG3479	Phenolic acid decarboxylase
CO218_07955	COG1307	EDD domain protein, DegV family
CO218_08005	COG0445	tRNA wobble uridine modification
CO218_08010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CO218_08015	COG1847	R3H domain protein
CO218_08020	COG0706	membrane insertase activity
CO218_08025	COG0594	ribonuclease P activity
CO218_08030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CO218_08035	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CO218_08040	COG0592	DNA-directed DNA polymerase activity
CO218_08045	COG2501	S4 domain
CO218_08050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CO218_08055	COG0187	DNA topoisomerase II activity
CO218_08065	COG0360	Binds together with S18 to 16S ribosomal RNA
CO218_08070	COG0629	single-stranded DNA binding
CO218_08075	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CO218_08085	COG0359	binds to the 23S rRNA
CO218_08090	COG0305	Participates in initiation and elongation during chromosome replication
CO218_08095	COG2814	Major facilitator Superfamily
CO218_08100	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CO218_08105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CO218_08110	COG4166	transmembrane transport
CO218_08120	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CO218_08125	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CO218_08130	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CO218_08135	COG0297	glycogen (starch) synthase activity
CO218_08155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO218_08160	COG1554	hydrolase, family 65, central catalytic
CO218_08170	COG1278	Cold shock
CO218_08185	COG0745	RESPONSE REGULATOR receiver
CO218_08190	COG5002	protein histidine kinase activity
CO218_08200	COG4853	Protein conserved in bacteria
CO218_08205	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CO218_08210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CO218_08215	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CO218_08260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CO218_08265	COG1028	Short-chain dehydrogenase reductase Sdr
CO218_08275	COG0778	Nitroreductase
CO218_08280	COG2508	Transcriptional regulator
CO218_08290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO218_08295	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CO218_08305	COG2365	Tyrosine phosphatase family
CO218_08330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CO218_08360	COG0604	alcohol dehydrogenase
CO218_08385	COG2267	carboxylic ester hydrolase activity
CO218_08390	COG3022	response to hydroperoxide
CO218_08400	COG4166	transmembrane transport
CO218_08425	COG1122	ATPase activity
CO218_08430	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CO218_08435	COG0310	cobalt ion transport
CO218_08440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO218_08445	COG3875	lactate racemase activity
CO218_08450	COG1691	(AIR) carboxylase
CO218_08455	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CO218_08460	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CO218_08465	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO218_08470	COG1606	tRNA processing
CO218_08475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CO218_08475	COG0604	alcohol dehydrogenase
CO218_08475	COG3321	synthase
CO218_08475	COG4221	oxidoreductase activity
CO218_08480	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CO218_08485	COG0351	phosphomethylpyrimidine kinase
CO218_08490	COG0352	thiamine-phosphate diphosphorylase activity
CO218_08500	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CO218_08515	COG1113	amino acid transport
CO218_08525	COG2267	carboxylic ester hydrolase activity
CO218_08530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO218_08535	COG1983	PspC domain protein
CO218_08570	COG0640	Transcriptional regulator
CO218_08575	COG2807	transmembrane transport
CO218_08580	COG0656	L-ascorbic acid biosynthetic process
CO218_08615	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CO218_08620	COG1122	ATPase activity
CO218_08625	COG4720	Psort location CytoplasmicMembrane, score
CO218_08635	COG2188	Transcriptional regulator
CO218_08660	COG1028	Short-chain dehydrogenase reductase Sdr
CO218_08665	COG1131	(ABC) transporter
CO218_08680	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CO218_08685	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CO218_08690	COG1309	transcriptional regulator
CO218_08695	COG2376	Dihydroxyacetone kinase
CO218_08700	COG2376	Dihydroxyacetone kinase
CO218_08705	COG1461	Dihydroxyacetone kinase
CO218_08710	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CO218_08715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO218_08720	COG1609	Transcriptional regulator
CO218_08725	COG1609	Transcriptional regulator
CO218_08730	COG0366	Alpha amylase catalytic
CO218_08735	COG2182	Extracellular solute-binding protein
CO218_08740	COG1175	transmembrane transport
CO218_08745	COG3833	ABC-type maltose transport systems, permease component
CO218_08755	COG0366	Alpha amylase catalytic
CO218_08760	COG3842	ATPase activity
CO218_08805	COG4166	transmembrane transport
CO218_08810	COG4166	transmembrane transport
CO218_08820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO218_08825	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CO218_08830	COG0406	alpha-ribazole phosphatase activity
CO218_08835	COG0667	Aldo Keto reductase
CO218_08880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CO218_08885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CO218_08890	COG0488	(ABC) transporter
CO218_08900	COG1122	ATPase activity
CO218_08910	COG0386	Belongs to the glutathione peroxidase family
CO218_08920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO218_08935	COG0363	glucosamine-6-phosphate deaminase activity
CO218_08945	COG2213	PTS system mannitol-specific
CO218_08955	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO218_08960	COG0246	Mannitol dehydrogenase
CO218_08970	COG3118	belongs to the thioredoxin family
CO218_09000	COG0431	NADPH-dependent FMN reductase
CO218_09005	COG2188	Transcriptional regulator
CO218_09015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO218_09030	COG3964	amidohydrolase
CO218_09055	COG1045	serine acetyltransferase
CO218_09060	COG0626	cystathionine gamma-synthase activity
CO218_09065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CO218_09095	COG2188	Transcriptional regulator
CO218_09110	COG2190	(PTS) system
CO218_09110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO218_09110	COG1263	PTS System
CO218_09120	COG0163	prenyltransferase activity
CO218_09130	COG1959	2 iron, 2 sulfur cluster binding
CO218_09135	COG1309	transcriptional regulator
CO218_09140	COG1914	H( )-stimulated, divalent metal cation uptake system
CO218_09160	COG2814	Major facilitator Superfamily
CO218_09175	COG5002	protein histidine kinase activity
CO218_09180	COG0745	RESPONSE REGULATOR receiver
CO218_09190	COG1737	Transcriptional regulator
CO218_09195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO218_09210	COG1316	TRANSCRIPTIONal
CO218_09215	COG0277	FAD linked oxidase domain protein
CO218_09225	COG2357	RelA SpoT domain protein
CO218_09235	COG1033	growth of symbiont in host cell
CO218_09235	COG2409	Drug exporters of the RND superfamily
CO218_09235	COG1033	growth of symbiont in host cell
CO218_09235	COG2409	Drug exporters of the RND superfamily
CO218_09240	COG2818	Glycosylase
CO218_09250	COG0577	efflux transmembrane transporter activity
CO218_09255	COG1136	(ABC) transporter
CO218_09270	COG0741	lytic transglycosylase activity
CO218_09285	COG1388	LysM domain
CO218_09285	COG3942	CHAP domain
CO218_09315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CO218_09325	COG1846	Transcriptional regulator
CO218_09330	COG1252	NADH dehydrogenase
CO218_09355	COG3842	ATPase activity
CO218_09385	COG1725	Transcriptional regulator
CO218_09390	COG1131	(ABC) transporter
CO218_09410	COG1454	alcohol dehydrogenase
CO218_09410	COG1012	belongs to the aldehyde dehydrogenase family
CO218_09445	COG1268	BioY protein
CO218_09460	COG0436	Aminotransferase
CO218_09470	COG1682	transport, permease protein
CO218_09475	COG1134	teichoic acid transport
CO218_09495	COG2814	Major facilitator Superfamily
CO218_09505	COG2801	Transposase and inactivated derivatives
CO218_09510	COG0004	ammonium transporteR
CO218_09530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CO218_09540	COG3759	membrane
CO218_09545	COG1881	PFAM PEBP family protein
CO218_09580	COG0300	oxidoreductase activity
CO218_09590	COG0328	RNA-DNA hybrid ribonuclease activity
CO218_09600	COG1125	glycine betaine transport
CO218_09610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CO218_09655	COG2274	protein secretion by the type I secretion system
CO218_09705	COG3973	AAA domain
CO218_09710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CO218_09715	COG0180	Tryptophanyl-tRNA synthetase
CO218_09720	COG2188	Transcriptional regulator
CO218_09740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO218_09745	COG2723	6-phospho-beta-galactosidase activity
CO218_09750	COG1940	carbohydrate kinase activity
CO218_09760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CO218_09765	COG0248	Ppx GppA phosphatase
CO218_09780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CO218_09785	COG1801	Protein of unknown function DUF72
CO218_09795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO218_09795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO218_09800	COG2801	Transposase and inactivated derivatives
CO218_09810	COG2814	Major facilitator Superfamily
CO218_09825	COG0084	hydrolase, TatD family'
CO218_09830	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CO218_09835	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CO218_09840	COG4466	Protein conserved in bacteria
CO218_09845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CO218_09855	COG1121	(ABC) transporter
CO218_09860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO218_09860	COG1321	iron dependent repressor
CO218_09880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO218_09885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CO218_09895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO218_09920	COG1078	dGTPase activity
CO218_09925	COG0095	Lipoate-protein ligase
CO218_09935	COG3343	RNA polymerase activity
CO218_09940	COG0504	CTP synthase activity
CO218_09945	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CO218_09950	COG0814	amino acid
CO218_09960	COG1760	l-serine dehydratase
CO218_09965	COG1760	l-serine dehydratase
CO218_09980	COG3328	transposase activity
CO218_09995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO218_10000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CO218_10005	COG0254	rRNA binding
CO218_10015	COG3764	Sortase (surface protein transpeptidase)
CO218_10020	COG1704	LemA family
CO218_10025	COG0501	Belongs to the peptidase M48B family
CO218_10035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CO218_10055	COG0736	holo-[acyl-carrier-protein] synthase activity
CO218_10060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CO218_10070	COG2337	Toxic component of a toxin-antitoxin (TA) module
CO218_10095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CO218_10100	COG0505	Belongs to the CarA family
CO218_10110	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CO218_10115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CO218_10120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CO218_10125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CO218_10145	COG0039	L-malate dehydrogenase activity
CO218_10150	COG0193	aminoacyl-tRNA hydrolase activity
CO218_10155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CO218_10160	COG2244	polysaccharide biosynthetic process
CO218_10165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CO218_10175	COG1098	S1 RNA binding domain
CO218_10180	COG0037	tRNA processing
CO218_10195	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CO218_10205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CO218_10245	COG3104	oligopeptide transport
CO218_10295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CO218_10305	COG2188	Transcriptional regulator
CO218_10315	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CO218_10320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CO218_10335	COG2183	response to ionizing radiation
CO218_10340	COG3091	SprT-like family
CO218_10345	COG0460	homoserine dehydrogenase
CO218_10350	COG0083	homoserine kinase activity
CO218_10370	COG3715	PTS system
CO218_10375	COG3716	PTS system mannose fructose sorbose family IID component
CO218_10385	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CO218_10385	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CO218_10390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO218_10390	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO218_10395	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO218_10395	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO218_10400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CO218_10410	COG0439	Biotin carboxylase
CO218_10420	COG0825	malonyl-CoA metabolic process
CO218_10425	COG1316	TRANSCRIPTIONal
CO218_10440	COG0697	spore germination
CO218_10445	COG0588	phosphoglycerate mutase activity
CO218_10455	COG2801	Transposase and inactivated derivatives
CO218_10470	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CO218_10480	COG0756	dUTP diphosphatase activity
CO218_10500	COG4956	integral membrane protein (PIN domain superfamily)
CO218_10505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CO218_10510	COG0215	cysteine-tRNA ligase activity
CO218_10515	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CO218_10520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO218_10535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO218_10545	COG0250	Participates in transcription elongation, termination and antitermination
CO218_10555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CO218_10560	COG0081	regulation of translation
CO218_10565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CO218_10570	COG0222	ribosome binding
CO218_10595	COG1611	Belongs to the LOG family
CO218_10605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CO218_10610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CO218_10615	COG2813	Specifically methylates the guanine in position
CO218_10630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CO218_10635	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CO218_10640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CO218_10650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CO218_10655	COG3870	Protein conserved in bacteria
CO218_10660	COG0470	DNA polymerase III
CO218_10665	COG4467	Involved in initiation control of chromosome replication
CO218_10680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CO218_10685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CO218_10690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO218_10695	COG3639	organic phosphonate transmembrane transporter activity
CO218_10705	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CO218_10715	COG1214	PFAM Peptidase M22, glycoprotease
CO218_10720	COG0456	acetyltransferase
CO218_10725	COG0456	acetyltransferase
CO218_10730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CO218_10740	COG0488	(ABC) transporter
CO218_10745	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CO218_10755	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CO218_10760	COG0459	protein refolding
CO218_10765	COG0531	amino acid
CO218_10770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CO218_10775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CO218_10780	COG2801	Transposase and inactivated derivatives
CO218_10790	COG1739	Uncharacterized protein family UPF0029
CO218_10795	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CO218_10810	COG0653	protein targeting
CO218_10825	COG0745	RESPONSE REGULATOR receiver
CO218_10830	COG5002	protein histidine kinase activity
CO218_10840	COG0573	inorganic phosphate transmembrane transporter activity
CO218_10845	COG0581	inorganic phosphate transmembrane transporter activity
CO218_10850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO218_10855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO218_10860	COG0704	Plays a role in the regulation of phosphate uptake
CO218_10865	COG1983	PspC domain protein
CO218_10870	COG1950	PFAM Membrane protein of
CO218_10875	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CO218_10880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CO218_10885	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CO218_10890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CO218_10945	COG0492	ferredoxin-NADP+ reductase activity
CO218_10960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO218_10970	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO218_10980	COG2814	Major facilitator Superfamily
CO218_10990	COG0556	nucleotide-excision repair
CO218_10995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CO218_11000	COG1854	S-ribosylhomocysteine lyase activity
CO218_11005	COG0137	argininosuccinate synthase activity
CO218_11010	COG0165	Argininosuccinate lyase
CO218_11020	COG1660	Displays ATPase and GTPase activities
CO218_11030	COG1481	regulation of sporulation
CO218_11040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO218_11045	COG0740	serine-type endopeptidase activity
CO218_11055	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CO218_11060	COG2390	Transcriptional regulator
CO218_11070	COG0126	phosphoglycerate kinase activity
CO218_11075	COG0149	triose-phosphate isomerase activity
CO218_11080	COG0148	phosphopyruvate hydratase activity
CO218_11095	COG0038	chloride channel
CO218_11100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CO218_11110	COG0557	exoribonuclease II activity
CO218_11115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CO218_11130	COG0765	amino acid transport
CO218_11135	COG1126	abc transporter atp-binding protein
CO218_11145	COG0561	phosphatase activity
CO218_11150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CO218_11155	COG0280	phosphate acetyltransferase
CO218_11160	COG0802	atpase or kinase
CO218_11175	COG0708	Exodeoxyribonuclease III
CO218_11185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CO218_11190	COG0025	NhaP-type Na H and K H
CO218_11215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO218_11230	COG1131	(ABC) transporter
CO218_11235	COG3328	transposase activity
CO218_11245	COG1695	Transcriptional regulator
CO218_11280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CO218_11290	COG0561	phosphatase activity
CO218_11300	COG2017	converts alpha-aldose to the beta-anomer
CO218_11315	COG0778	Nitroreductase
CO218_11345	COG1393	Belongs to the ArsC family
CO218_11360	COG0477	Major facilitator Superfamily
CO218_11365	COG0248	Ppx GppA phosphatase
CO218_11370	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CO218_11380	COG3475	LICD family
CO218_11395	COG2252	PERMEase
CO218_11405	COG0196	riboflavin kinase activity
CO218_11410	COG0028	Belongs to the TPP enzyme family
CO218_11415	COG2267	carboxylic ester hydrolase activity
CO218_11425	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CO218_11425	COG2755	lipolytic protein G-D-S-L family
CO218_11430	COG2936	dipeptidyl-peptidase activity
CO218_11445	COG0531	amino acid
CO218_11470	COG0194	GDP metabolic process
CO218_11475	COG0735	belongs to the Fur family
CO218_11490	COG0546	phosphoglycolate phosphatase activity
CO218_11495	COG0436	Aminotransferase
CO218_11500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO218_11520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO218_11525	COG0765	amino acid transport
CO218_11530	COG0765	amino acid transport
CO218_11535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO218_11535	COG1263	PTS System
CO218_11535	COG2190	(PTS) system
CO218_11545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO218_11545	COG1263	PTS System
CO218_11550	COG3394	polysaccharide catabolic process
CO218_11555	COG0531	amino acid
CO218_11565	COG1846	Transcriptional regulator
CO218_11595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CO218_11615	COG0588	phosphoglycerate mutase activity
CO218_11620	COG0475	glutathione-regulated potassium exporter activity
CO218_11620	COG0569	domain protein
CO218_11625	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CO218_11625	COG0456	acetyltransferase
CO218_11630	COG0586	Pfam SNARE associated Golgi protein
CO218_11635	COG3973	AAA domain
CO218_11640	COG2070	2-Nitropropane dioxygenase
CO218_11645	COG1072	(Pantothenic acid kinase))
CO218_11650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CO218_11650	COG0519	Catalyzes the synthesis of GMP from XMP
CO218_11665	COG1266	CAAX protease self-immunity
CO218_11670	COG1733	regulation of RNA biosynthetic process
CO218_11675	COG2814	Major facilitator Superfamily
CO218_11715	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CO218_11715	COG2755	lipolytic protein G-D-S-L family
CO218_11720	COG2261	transglycosylase associated protein
CO218_11735	COG1302	Protein conserved in bacteria
CO218_11785	COG0308	aminopeptidase N
CO218_11805	COG2801	Transposase and inactivated derivatives
CO218_11810	COG2826	transposase and inactivated derivatives, IS30 family
CO218_11835	COG2801	Transposase and inactivated derivatives
CO218_11860	COG0583	DNA-binding transcription factor activity
CO218_11865	COG1053	succinate dehydrogenase
CO218_11870	COG2801	Transposase and inactivated derivatives
CO218_11890	COG0017	Asparaginyl-tRNA synthetase
CO218_11895	COG2502	aspartate--ammonia ligase
CO218_11900	COG4690	dipeptidase activity
CO218_11920	COG0514	ATP-dependent DNA helicase (RecQ)
CO218_11925	COG0564	pseudouridine synthase activity
CO218_11930	COG0640	Transcriptional regulator
CO218_11980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CO218_11985	COG0527	aspartate kinase activity
CO218_11990	COG0367	asparagine synthase
CO218_12035	COG2814	Major facilitator Superfamily
CO218_12055	COG1278	Cold shock
CO218_12060	COG2966	Psort location CytoplasmicMembrane, score
CO218_12070	COG1316	TRANSCRIPTIONal
CO218_12090	COG1959	2 iron, 2 sulfur cluster binding
CO218_12095	COG0028	Belongs to the TPP enzyme family
CO218_12100	COG0833	amino acid
CO218_12110	COG1428	Deoxynucleoside kinase
CO218_12115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CO218_12160	COG4463	regulation of RNA biosynthetic process
CO218_12175	COG0085	RNA polymerase activity
CO218_12180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CO218_12185	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CO218_12190	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CO218_12195	COG0049	tRNA binding
CO218_12200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CO218_12205	COG0051	transcription antitermination factor activity, RNA binding
CO218_12210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CO218_12215	COG0088	Forms part of the polypeptide exit tunnel
CO218_12220	COG0089	rRNA binding
CO218_12225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CO218_12230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CO218_12235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CO218_12240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CO218_12245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CO218_12250	COG0255	Belongs to the universal ribosomal protein uL29 family
CO218_12255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CO218_12260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CO218_12265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CO218_12270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CO218_12275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CO218_12280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CO218_12285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CO218_12290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CO218_12295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CO218_12300	COG1841	ribosomal large subunit assembly
CO218_12305	COG0200	Binds to the 23S rRNA
CO218_12315	COG0563	adenylate kinase activity
CO218_12320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CO218_12325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CO218_12330	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CO218_12335	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CO218_12340	COG0202	RNA polymerase activity
CO218_12345	COG0203	ribosomal protein L17
CO218_12375	COG4939	FMN-binding domain protein
CO218_12385	COG1122	ATPase activity
CO218_12390	COG1122	ATPase activity
CO218_12400	COG0101	tRNA pseudouridine synthase activity
CO218_12405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CO218_12410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CO218_12440	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CO218_12445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CO218_12450	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CO218_12455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CO218_12465	COG2151	metal-sulfur cluster biosynthetic enzyme
CO218_12470	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CO218_12480	COG4977	sequence-specific DNA binding
CO218_12480	COG1917	Cupin 2, conserved barrel domain protein
CO218_12485	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CO218_12490	COG1121	(ABC) transporter
CO218_12495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO218_12500	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO218_12510	COG0039	L-malate dehydrogenase activity
CO218_12515	COG0471	metal ion transport
CO218_12535	COG3052	prosthetic group binding
CO218_12555	COG0114	fumarate hydratase activity
CO218_12560	COG1053	succinate dehydrogenase
CO218_12570	COG0583	DNA-binding transcription factor activity
CO218_12580	COG0281	malic enzyme
CO218_12595	COG0531	amino acid
CO218_12600	COG4684	Psort location CytoplasmicMembrane, score
CO218_12615	COG1271	oxidase subunit
CO218_12620	COG1294	oxidase, subunit
CO218_12625	COG4988	ABC transporter
CO218_12630	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CO218_12645	COG0142	geranyltranstransferase activity
CO218_12660	COG2801	Transposase and inactivated derivatives
CO218_12670	COG1705	Flagellar rod assembly protein muramidase FlgJ
CO218_12675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO218_12680	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CO218_12685	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CO218_12695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CO218_12700	COG4851	CamS sex pheromone cAM373 precursor
CO218_12705	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO218_12710	COG0154	amidase activity
CO218_12715	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO218_12720	COG1597	lipid kinase activity
CO218_12725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO218_12750	COG1737	Transcriptional regulator
CO218_12765	COG1278	Cold shock
CO218_12770	COG0673	inositol 2-dehydrogenase activity
CO218_12775	COG0513	Belongs to the DEAD box helicase family
CO218_12790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO218_12815	COG2801	Transposase and inactivated derivatives
CO218_12825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CO218_12835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CO218_12845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO218_12915	COG2137	regulation of response to DNA damage stimulus
CO218_12920	COG3557	Belongs to the UPF0374 family
CO218_12945	COG0628	permease
CO218_12950	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CO218_12955	COG2610	gluconate transmembrane transporter activity
CO218_12960	COG1070	Carbohydrate kinase
CO218_12965	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CO218_12970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO218_12975	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CO218_13005	COG4166	transmembrane transport
CO218_13010	COG0601	transmembrane transport
CO218_13015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO218_13020	COG0444	Belongs to the ABC transporter superfamily
CO218_13025	COG4608	Belongs to the ABC transporter superfamily
CO218_13040	COG0542	response to heat
CO218_13060	COG0438	transferase activity, transferring glycosyl groups
CO218_13065	COG0438	transferase activity, transferring glycosyl groups
CO218_13075	COG1686	Belongs to the peptidase S11 family
CO218_13080	COG0436	Aminotransferase
CO218_13085	COG4703	Protein of unknown function (DUF1797)
CO218_13090	COG1368	sulfuric ester hydrolase activity
CO218_13180	COG2826	transposase and inactivated derivatives, IS30 family
CO218_13185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO218_13205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CO218_13220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CO218_13225	COG0833	amino acid
CO218_13230	COG2040	homocysteine
CO218_13245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CO218_13250	COG0477	Major facilitator Superfamily
CO218_13290	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CO218_13300	COG0495	leucyl-tRNA aminoacylation
CO218_13315	COG2244	polysaccharide biosynthetic process
CO218_13320	COG1187	pseudouridine synthase activity
CO218_13325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CO218_13330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO218_13340	COG3842	ATPase activity
CO218_13345	COG1175	transmembrane transport
CO218_13350	COG0395	ABC-type sugar transport system, permease component
CO218_13360	COG0584	glycerophosphoryl diester phosphodiesterase
CO218_13365	COG1428	Deoxynucleoside kinase
CO218_13370	COG1970	mechanosensitive ion channel activity
CO218_13375	COG1511	domain protein
CO218_13375	COG1511	domain protein
CO218_13405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO218_13410	COG0789	Transcriptional regulator
CO218_13425	COG0561	phosphatase activity
CO218_13450	COG3279	Response regulator of the LytR AlgR family
CO218_13470	COG1846	Transcriptional regulator
CO218_13525	COG0646	methionine synthase
CO218_13525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CO218_13530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CO218_13540	COG2046	Belongs to the sulfate adenylyltransferase family
CO218_13545	COG0529	Catalyzes the synthesis of activated sulfate
CO218_13550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CO218_13580	COG0534	Mate efflux family protein
CO218_13600	COG2153	protein acetylation
CO218_13605	COG0018	arginyl-trna synthetase
CO218_13635	COG1447	Phosphotransferase system cellobiose-specific component IIA
CO218_13640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO218_13645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO218_13660	COG1376	ErfK ybiS ycfS ynhG family protein
CO218_13665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO218_13670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO218_13680	COG0436	Aminotransferase
CO218_13685	COG1438	arginine binding
CO218_13695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO218_13700	COG3679	Belongs to the UPF0342 family
CO218_13705	COG0420	3'-5' exonuclease activity
CO218_13710	COG4717	serine-type aminopeptidase activity
CO218_13715	COG3481	metal-dependent phosphohydrolase, HD sub domain
CO218_13730	COG0583	DNA-binding transcription factor activity
CO218_13785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CO218_13785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CO218_13790	COG0307	riboflavin synthase, alpha
CO218_13795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CO218_13795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CO218_13800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CO218_13805	COG1309	transcriptional regulator
CO218_13820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO218_13830	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO218_13860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CO218_13870	COG0537	adenosine 5'-monophosphoramidase activity
CO218_13875	COG1131	(ABC) transporter
CO218_13880	COG4473	ABC transporter
CO218_13885	COG0510	thiamine kinase activity
CO218_13890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CO218_13900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO218_13905	COG1674	ftsk spoiiie
CO218_13910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CO218_13935	COG0719	Fe-S assembly protein
CO218_13940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CO218_13950	COG0719	Fe-S assembly protein
CO218_13960	COG1120	ATPase activity
CO218_13965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO218_13970	COG0716	FMN binding
CO218_13985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CO218_13990	COG2223	nitrite transmembrane transporter activity
CO218_13995	COG2151	metal-sulfur cluster biosynthetic enzyme
CO218_14020	COG2197	response regulator
CO218_14045	COG0315	cyclic pyranopterin monophosphate synthase activity
CO218_14050	COG1763	Mo-molybdopterin cofactor biosynthetic process
CO218_14055	COG0303	'Molybdopterin
CO218_14065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CO218_14070	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CO218_14075	COG1140	nitrate reductase beta subunit
CO218_14085	COG2181	nitrate reductase activity
CO218_14105	COG3655	Transcriptional regulator
CO218_14110	COG0670	Belongs to the BI1 family
CO218_14115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO218_14115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO218_14120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CO218_14125	COG0237	dephospho-CoA kinase activity
CO218_14130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CO218_14135	COG3611	Membrane attachment protein
CO218_14140	COG1484	DNA-dependent DNA replication
CO218_14145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CO218_14150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CO218_14155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CO218_14160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CO218_14170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CO218_14175	COG0604	alcohol dehydrogenase
CO218_14180	COG1733	regulation of RNA biosynthetic process
CO218_14205	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CO218_14210	COG1534	Rna-binding protein
CO218_14215	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CO218_14220	COG1713	HD superfamily hydrolase involved in NAD metabolism
CO218_14225	COG0799	negative regulation of ribosome biogenesis
CO218_14230	COG2226	methyltransferase
CO218_14235	COG1323	Belongs to the UPF0348 family
CO218_14245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CO218_14260	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CO218_14270	COG0745	RESPONSE REGULATOR receiver
CO218_14275	COG5002	protein histidine kinase activity
CO218_14280	COG3328	transposase activity
CO218_14290	COG0419	ATPase involved in DNA repair
CO218_14305	COG0706	membrane insertase activity
CO218_14310	COG1254	Belongs to the acylphosphatase family
CO218_14315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO218_14325	COG1733	regulation of RNA biosynthetic process
CO218_14330	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CO218_14335	COG0072	phenylalanine-tRNA ligase activity
CO218_14335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO218_14340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CO218_14345	COG0572	uridine kinase
CO218_14350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO218_14365	COG4841	protein insertion into membrane
CO218_14375	COG0768	penicillin binding
CO218_14380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO218_14385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CO218_14390	COG0457	Tetratricopeptide repeat
CO218_14390	COG0705	Rhomboid family
CO218_14400	COG1940	carbohydrate kinase activity
CO218_14420	COG0584	glycerophosphoryl diester phosphodiesterase
CO218_14425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CO218_14430	COG0789	Transcriptional regulator
CO218_14480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CO218_14490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CO218_14495	COG0006	proline dipeptidase activity
CO218_14500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CO218_14505	COG1302	Protein conserved in bacteria
CO218_14510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CO218_14515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CO218_14520	COG1570	exodeoxyribonuclease VII activity
CO218_14525	COG1722	exodeoxyribonuclease VII activity
CO218_14530	COG0142	geranyltranstransferase activity
CO218_14535	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CO218_14540	COG1438	arginine binding
CO218_14545	COG0497	DNA recombination
CO218_14560	COG1732	Glycine betaine
CO218_14575	COG0194	GDP metabolic process
CO218_14580	COG1758	RNA polymerase activity
CO218_14585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CO218_14590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CO218_14595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CO218_14600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CO218_14600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CO218_14605	COG0631	protein serine/threonine phosphatase activity
CO218_14610	COG2815	serine threonine protein kinase
CO218_14610	COG0515	serine threonine protein kinase
CO218_14615	COG1162	GTPase activity
CO218_14620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CO218_14625	COG1564	THIamine pyrophosphokinase
CO218_14630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CO218_14635	COG1302	Protein conserved in bacteria
CO218_14640	COG1461	Dihydroxyacetone kinase
CO218_14645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CO218_14650	COG0416	fatty acid biosynthetic process
CO218_14655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO218_14660	COG0571	ribonuclease III activity
CO218_14665	COG1196	nuclear chromosome segregation
CO218_14670	COG0552	protein localization to endoplasmic reticulum
CO218_14675	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CO218_14680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CO218_14685	COG0228	four-way junction DNA binding
CO218_14690	COG1837	Belongs to the UPF0109 family
CO218_14695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CO218_14700	COG0336	Belongs to the RNA methyltransferase TrmD family
CO218_14705	COG0335	large ribosomal subunit rRNA binding
CO218_14725	COG1131	(ABC) transporter
CO218_14740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CO218_14740	COG0512	Glutamine amidotransferase of anthranilate synthase
CO218_14745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CO218_14750	COG0134	indole-3-glycerol-phosphate synthase activity
CO218_14755	COG0135	phosphoribosylanthranilate isomerase activity
CO218_14760	COG0133	tryptophan synthase activity
CO218_14765	COG0159	tryptophan synthase activity
CO218_14780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO218_14790	COG1473	amidohydrolase
CO218_14795	COG1063	alcohol dehydrogenase
CO218_14805	COG0300	oxidoreductase activity
CO218_14815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CO218_14820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CO218_14825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO218_14830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CO218_14835	COG1028	Short-chain dehydrogenase reductase Sdr
CO218_14840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CO218_14855	COG0439	Biotin carboxylase
CO218_14870	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CO218_14880	COG1811	Na channel or pump
CO218_14885	COG0583	DNA-binding transcription factor activity
CO218_14890	COG1607	acyl-coa hydrolase
CO218_14905	COG0477	Major facilitator Superfamily
CO218_14970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CO218_14980	COG3397	chitin binding
CO218_14985	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CO218_14995	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CO218_15005	COG3152	Membrane
CO218_15010	COG1597	lipid kinase activity
CO218_15025	COG2261	transglycosylase associated protein
CO218_15030	COG3237	CsbD-like
CO218_15045	COG1942	4-Oxalocrotonate Tautomerase
CO218_15095	COG1192	Involved in chromosome partitioning
CO218_15240	COG0542	response to heat
CO218_15275	COG3328	transposase activity
CO218_15285	COG0489	protein tyrosine kinase activity
CO218_15290	COG4464	protein tyrosine phosphatase activity
CO218_15305	COG1914	H( )-stimulated, divalent metal cation uptake system
CO218_15335	COG2233	PERMEase
CO218_15340	COG4372	Transposase
CO218_15355	COG2801	Transposase and inactivated derivatives
CO218_15370	COG2261	transglycosylase associated protein
CO218_15375	COG0028	Belongs to the TPP enzyme family
CO218_15385	COG1192	Involved in chromosome partitioning
CO218_15420	COG1914	H( )-stimulated, divalent metal cation uptake system
CO218_15430	COG3328	transposase activity
CO218_15505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CO218_15520	COG1397	ADP-ribosylglycohydrolase
CO218_15530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO218_15595	COG2801	Transposase and inactivated derivatives
CO218_15650	COG2826	transposase and inactivated derivatives, IS30 family
CO218_15675	COG1393	Belongs to the ArsC family
CO218_15725	COG0531	amino acid
CO218_15750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO218_15775	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CO218_15810	COG0551	DNA topoisomerase type I activity
CO218_15810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CO218_15925	COG0028	Belongs to the TPP enzyme family
CO218_15935	COG2801	Transposase and inactivated derivatives
CO218_15955	COG1192	Involved in chromosome partitioning
CO218_16025	COG2826	transposase and inactivated derivatives, IS30 family
CO218_16030	COG1192	Involved in chromosome partitioning
CO218_16045	COG2826	transposase and inactivated derivatives, IS30 family
CO218_16050	COG1388	LysM domain
CO218_16065	COG3620	sequence-specific DNA binding
CO218_16070	COG3328	transposase activity
CO218_16135	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA