locus-tag	class	description
GFB67_00010	COG0592	DNA-directed DNA polymerase activity
GFB67_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GFB67_00025	COG0187	DNA topoisomerase II activity
GFB67_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFB67_00035	COG0360	Binds together with S18 to 16S ribosomal RNA
GFB67_00040	COG0629	single-stranded DNA binding
GFB67_00055	COG0359	binds to the 23S rRNA
GFB67_00060	COG0305	Participates in initiation and elongation during chromosome replication
GFB67_00070	COG1136	(ABC) transporter
GFB67_00085	COG1285	pathogenesis
GFB67_00110	COG4619	ABC transporter
GFB67_00115	COG0390	transport system, permease component
GFB67_00170	COG1942	4-Oxalocrotonate Tautomerase
GFB67_00205	COG1482	cell wall glycoprotein biosynthetic process
GFB67_00235	COG1191	sigma factor activity
GFB67_00240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFB67_00255	COG0463	Glycosyl transferase, family 2
GFB67_00265	COG1307	EDD domain protein, DegV family
GFB67_00280	COG0588	phosphoglycerate mutase activity
GFB67_00310	COG1268	BioY protein
GFB67_00320	COG1011	Hydrolase
GFB67_00335	COG0708	Exodeoxyribonuclease III
GFB67_00350	COG0656	L-ascorbic acid biosynthetic process
GFB67_00355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFB67_00370	COG2096	Adenosyltransferase
GFB67_00380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFB67_00390	COG0242	peptide deformylase activity
GFB67_00420	COG1132	(ABC) transporter
GFB67_00435	COG1193	negative regulation of DNA recombination
GFB67_00445	COG0583	DNA-binding transcription factor activity
GFB67_00455	COG1940	carbohydrate kinase activity
GFB67_00465	COG2814	Major facilitator Superfamily
GFB67_00480	COG0583	DNA-binding transcription factor activity
GFB67_00485	COG1053	succinate dehydrogenase
GFB67_00485	COG3976	FMN-binding domain protein
GFB67_00515	COG0745	RESPONSE REGULATOR receiver
GFB67_00520	COG5002	protein histidine kinase activity
GFB67_00535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GFB67_00540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFB67_00580	COG1122	ATPase activity
GFB67_00585	COG0477	Major facilitator Superfamily
GFB67_00595	COG4555	ABC transporter
GFB67_00620	COG0501	Belongs to the peptidase M48B family
GFB67_00625	COG1704	LemA family
GFB67_00630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GFB67_00655	COG1126	abc transporter atp-binding protein
GFB67_00660	COG0765	amino acid transport
GFB67_00665	COG2094	Belongs to the DNA glycosylase MPG family
GFB67_00670	COG3189	MarR family transcriptional regulator
GFB67_00675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GFB67_00685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GFB67_00695	COG0328	RNA-DNA hybrid ribonuclease activity
GFB67_00705	COG1216	Glycosyl transferase, family 2
GFB67_00710	COG2267	carboxylic ester hydrolase activity
GFB67_00715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GFB67_00730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFB67_00760	COG0657	acetylesterase activity
GFB67_00760	COG2755	lipolytic protein G-D-S-L family
GFB67_00785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GFB67_00800	COG2365	Tyrosine phosphatase family
GFB67_00805	COG0589	response to stress
GFB67_00815	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GFB67_00820	COG3639	organic phosphonate transmembrane transporter activity
GFB67_00830	COG4166	transmembrane transport
GFB67_00845	COG0367	asparagine synthase
GFB67_00860	COG0602	queuosine metabolic process
GFB67_00875	COG2814	Major facilitator Superfamily
GFB67_00880	COG4545	Glutaredoxin-related protein
GFB67_00885	COG3590	peptidase
GFB67_00920	COG3951	Flagellar rod assembly protein muramidase FlgJ
GFB67_00920	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFB67_00930	COG0569	domain protein
GFB67_00930	COG0475	glutathione-regulated potassium exporter activity
GFB67_00945	COG0588	phosphoglycerate mutase activity
GFB67_00950	COG1316	TRANSCRIPTIONal
GFB67_00955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GFB67_00960	COG1368	sulfuric ester hydrolase activity
GFB67_01000	COG0302	gtp cyclohydrolase
GFB67_01000	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GFB67_01005	COG0285	dihydrofolate synthase activity
GFB67_01010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GFB67_01015	COG1051	belongs to the nudix hydrolase family
GFB67_01030	COG0765	amino acid transport
GFB67_01035	COG0765	amino acid transport
GFB67_01040	COG1126	abc transporter atp-binding protein
GFB67_01080	COG1473	amidohydrolase
GFB67_01100	COG1418	mRNA catabolic process
GFB67_01110	COG4166	transmembrane transport
GFB67_01115	COG4166	transmembrane transport
GFB67_01125	COG4166	transmembrane transport
GFB67_01130	COG0601	transmembrane transport
GFB67_01135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFB67_01140	COG0444	Belongs to the ABC transporter superfamily
GFB67_01145	COG4608	Belongs to the ABC transporter superfamily
GFB67_01170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFB67_01175	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GFB67_01180	COG0516	GMP reductase activity
GFB67_01185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFB67_01195	COG2233	PERMEase
GFB67_01205	COG0517	IMP dehydrogenase activity
GFB67_01205	COG0516	GMP reductase activity
GFB67_01215	COG2274	protein secretion by the type I secretion system
GFB67_01215	COG3271	cysteine-type peptidase activity
GFB67_01250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB67_01255	COG1126	abc transporter atp-binding protein
GFB67_01260	COG0765	amino acid transport
GFB67_01285	COG2040	homocysteine
GFB67_01305	COG0252	asparaginase activity
GFB67_01320	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GFB67_01330	COG1335	isochorismatase
GFB67_01375	COG1121	(ABC) transporter
GFB67_01410	COG2131	deaminase
GFB67_01420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFB67_01425	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFB67_01425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFB67_01430	COG0084	hydrolase, TatD family'
GFB67_01450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFB67_01465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GFB67_01470	COG1078	dGTPase activity
GFB67_01480	COG3343	RNA polymerase activity
GFB67_01485	COG0504	CTP synthase activity
GFB67_01490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFB67_01500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFB67_01515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GFB67_01530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GFB67_01535	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GFB67_01560	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GFB67_01565	COG4166	transmembrane transport
GFB67_01570	COG2195	Cleaves the N-terminal amino acid of tripeptides
GFB67_01575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GFB67_01580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GFB67_01630	COG1956	GAF domain-containing protein
GFB67_01635	COG0542	response to heat
GFB67_01795	COG0563	adenylate kinase activity
GFB67_01800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GFB67_01820	COG0202	RNA polymerase activity
GFB67_01840	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GFB67_01850	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GFB67_01855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GFB67_01880	COG1051	belongs to the nudix hydrolase family
GFB67_01910	COG1881	PFAM PEBP family protein
GFB67_01920	COG0436	Aminotransferase
GFB67_01955	COG2188	Transcriptional regulator
GFB67_01960	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GFB67_02005	COG1131	(ABC) transporter
GFB67_02010	COG3091	SprT-like family
GFB67_02025	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFB67_02035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFB67_02040	COG4851	CamS sex pheromone cAM373 precursor
GFB67_02050	COG0154	amidase activity
GFB67_02060	COG1597	lipid kinase activity
GFB67_02070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFB67_02105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFB67_02145	COG3759	membrane
GFB67_02150	COG1522	sequence-specific DNA binding
GFB67_02155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFB67_02170	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GFB67_02180	COG0488	(ABC) transporter
GFB67_02205	COG0670	Belongs to the BI1 family
GFB67_02215	COG4690	dipeptidase activity
GFB67_02230	COG0572	uridine kinase
GFB67_02235	COG0572	uridine kinase
GFB67_02245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB67_02250	COG0765	amino acid transport
GFB67_02255	COG0765	amino acid transport
GFB67_02260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB67_02270	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GFB67_02305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GFB67_02320	COG2188	Transcriptional regulator
GFB67_02340	COG1253	flavin adenine dinucleotide binding
GFB67_02350	COG0531	amino acid
GFB67_02365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFB67_02415	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GFB67_02425	COG0716	FMN binding
GFB67_02430	COG0024	Methionine aminopeptidase
GFB67_02435	COG1295	ribonuclease BN
GFB67_02440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GFB67_02455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFB67_02495	COG0542	response to heat
GFB67_02505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB67_02515	COG1393	Belongs to the ArsC family
GFB67_02520	COG4862	establishment of competence for transformation
GFB67_02545	COG2357	RelA SpoT domain protein
GFB67_02555	COG0564	pseudouridine synthase activity
GFB67_02570	COG2706	6-phosphogluconolactonase activity
GFB67_02580	COG0628	permease
GFB67_02595	COG1280	lysine exporter protein (LysE YggA)
GFB67_02595	COG1674	ftsk spoiiie
GFB67_02610	COG1028	Short-chain dehydrogenase reductase Sdr
GFB67_02615	COG1426	Protein conserved in bacteria
GFB67_02620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GFB67_02635	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFB67_02640	COG1739	Uncharacterized protein family UPF0029
GFB67_02645	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GFB67_02675	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GFB67_02685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GFB67_02690	COG0492	ferredoxin-NADP+ reductase activity
GFB67_02695	COG0556	nucleotide-excision repair
GFB67_02700	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFB67_02730	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GFB67_02770	COG2390	Transcriptional regulator
GFB67_02805	COG0561	phosphatase activity
GFB67_02810	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GFB67_02815	COG0280	phosphate acetyltransferase
GFB67_02820	COG0802	atpase or kinase
GFB67_02835	COG3842	ATPase activity
GFB67_02845	COG1177	transmembrane transport
GFB67_02890	COG2217	Heavy metal translocating P-type atpase
GFB67_02895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFB67_02900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFB67_02915	COG2200	EAL domain
GFB67_02915	COG2199	diguanylate cyclase activity
GFB67_02935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFB67_02945	COG0531	amino acid
GFB67_02960	COG0803	Belongs to the bacterial solute-binding protein 9 family
GFB67_02975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GFB67_02980	COG1459	type II secretion system
GFB67_03005	COG0827	DNA restriction-modification system
GFB67_03020	COG0745	RESPONSE REGULATOR receiver
GFB67_03025	COG5002	protein histidine kinase activity
GFB67_03025	COG3850	Histidine kinase
GFB67_03030	COG1368	sulfuric ester hydrolase activity
GFB67_03040	COG0166	Belongs to the GPI family
GFB67_03060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GFB67_03070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFB67_03075	COG1435	thymidine kinase activity
GFB67_03085	COG2890	protein-(glutamine-N5) methyltransferase activity
GFB67_03090	COG0009	L-threonylcarbamoyladenylate synthase
GFB67_03100	COG0356	it plays a direct role in the translocation of protons across the membrane
GFB67_03105	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFB67_03120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GFB67_03145	COG1077	Cell shape determining protein MreB Mrl
GFB67_03150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GFB67_03160	COG0772	Belongs to the SEDS family
GFB67_03175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GFB67_03190	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GFB67_03195	COG1104	cysteine desulfurase activity
GFB67_03205	COG1187	pseudouridine synthase activity
GFB67_03210	COG0525	valine-tRNA ligase activity
GFB67_03220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFB67_03225	COG2003	Belongs to the UPF0758 family
GFB67_03230	COG1077	Cell shape determining protein MreB Mrl
GFB67_03235	COG1792	Involved in formation and maintenance of cell shape
GFB67_03270	COG0768	penicillin binding
GFB67_03290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GFB67_03295	COG0849	cell division
GFB67_03300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GFB67_03325	COG1278	Cold shock
GFB67_03340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GFB67_03345	COG1104	cysteine desulfurase activity
GFB67_03360	COG0406	alpha-ribazole phosphatase activity
GFB67_03370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFB67_03375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFB67_03390	COG0242	peptide deformylase activity
GFB67_03395	COG1217	gtp-binding protein TYPA
GFB67_03410	COG0742	ribosomal rna small subunit methyltransferase
GFB67_03415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GFB67_03420	COG3480	Lon protease (S16) C-terminal proteolytic domain
GFB67_03425	COG1555	photosystem II stabilization
GFB67_03430	COG2333	competence protein COMEC
GFB67_03430	COG0658	competence protein
GFB67_03435	COG1466	dna polymerase III delta subunit
GFB67_03470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GFB67_03490	COG4166	transmembrane transport
GFB67_03510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFB67_03515	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFB67_03525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GFB67_03535	COG1053	succinate dehydrogenase
GFB67_03570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GFB67_03575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFB67_03580	COG0583	DNA-binding transcription factor activity
GFB67_03585	COG0018	arginyl-trna synthetase
GFB67_03595	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GFB67_03605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFB67_03610	COG0514	ATP-dependent DNA helicase (RecQ)
GFB67_03630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GFB67_03630	COG2755	lipolytic protein G-D-S-L family
GFB67_03640	COG0300	oxidoreductase activity
GFB67_03650	COG0737	Belongs to the 5'-nucleotidase family
GFB67_03670	COG4475	Protein of unknown function (DUF436)
GFB67_03680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GFB67_03695	COG0587	DNA-directed DNA polymerase activity
GFB67_03710	COG1116	anion transmembrane transporter activity
GFB67_03725	COG2996	Protein conserved in bacteria
GFB67_03735	COG0456	acetyltransferase
GFB67_03745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GFB67_03750	COG1187	pseudouridine synthase activity
GFB67_03755	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GFB67_03770	COG0539	negative regulation of cytoplasmic translation
GFB67_03800	COG0583	DNA-binding transcription factor activity
GFB67_03805	COG0583	DNA-binding transcription factor activity
GFB67_03860	COG1857	crispr-associated protein
GFB67_03875	COG1518	maintenance of DNA repeat elements
GFB67_03880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GFB67_03885	COG2357	RelA SpoT domain protein
GFB67_03890	COG0745	RESPONSE REGULATOR receiver
GFB67_03895	COG5002	protein histidine kinase activity
GFB67_03900	COG0183	Belongs to the thiolase family
GFB67_03910	COG3425	synthase
GFB67_03920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GFB67_03925	COG2264	protein methyltransferase activity
GFB67_03930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFB67_03935	COG1490	D-aminoacyl-tRNA deacylase activity
GFB67_03940	COG0124	histidyl-tRNA synthetase
GFB67_03945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GFB67_03960	COG0628	permease
GFB67_03970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFB67_03975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GFB67_03980	COG1028	Short-chain dehydrogenase reductase Sdr
GFB67_03985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFB67_04000	COG0439	Biotin carboxylase
GFB67_04010	COG0825	malonyl-CoA metabolic process
GFB67_04015	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GFB67_04165	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GFB67_04185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GFB67_04190	COG0573	inorganic phosphate transmembrane transporter activity
GFB67_04195	COG0581	inorganic phosphate transmembrane transporter activity
GFB67_04200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFB67_04205	COG0704	Plays a role in the regulation of phosphate uptake
GFB67_04215	COG5002	protein histidine kinase activity
GFB67_04250	COG1288	antiporter activity
GFB67_04255	COG1288	antiporter activity
GFB67_04260	COG1122	ATPase activity
GFB67_04265	COG1122	ATPase activity
GFB67_04280	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GFB67_04295	COG0561	phosphatase activity
GFB67_04325	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GFB67_04330	COG0187	DNA topoisomerase II activity
GFB67_04335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFB67_04340	COG1227	inorganic diphosphatase activity
GFB67_04345	COG1304	FMN binding
GFB67_04365	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GFB67_04375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GFB67_04375	COG1199	ATP-dependent helicase activity
GFB67_04385	COG0017	Asparaginyl-tRNA synthetase
GFB67_04390	COG3935	DnaD domain protein
GFB67_04395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GFB67_04400	COG0561	phosphatase activity
GFB67_04420	COG1506	peptidase
GFB67_04420	COG0823	Involved in the tonB-independent uptake of proteins
GFB67_04420	COG4946	Tricorn protease homolog
GFB67_04425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFB67_04440	COG3599	regulation of cell shape
GFB67_04450	COG0116	Belongs to the methyltransferase superfamily
GFB67_04465	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GFB67_04475	COG0564	pseudouridine synthase activity
GFB67_04480	COG0505	Belongs to the CarA family
GFB67_04485	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GFB67_04490	COG3830	Belongs to the UPF0237 family
GFB67_04500	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GFB67_04505	COG1307	EDD domain protein, DegV family
GFB67_04530	COG0406	alpha-ribazole phosphatase activity
GFB67_04560	COG4974	Belongs to the 'phage' integrase family
GFB67_04565	COG1929	Belongs to the glycerate kinase type-1 family
GFB67_04595	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GFB67_04645	COG2226	methyltransferase
GFB67_04650	COG1132	(ABC) transporter
GFB67_04690	COG0582	viral genome integration into host DNA
GFB67_04720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFB67_04730	COG1136	(ABC) transporter
GFB67_04755	COG3976	FMN-binding domain protein
GFB67_04755	COG1053	succinate dehydrogenase
GFB67_04775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFB67_04790	COG0436	Aminotransferase
GFB67_04795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GFB67_04800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFB67_04805	COG1473	amidohydrolase
GFB67_04810	COG2171	N-acyltransferase activity
GFB67_04815	COG0527	aspartate kinase activity
GFB67_04835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFB67_04880	COG1136	(ABC) transporter
GFB67_04890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFB67_04920	COG0582	viral genome integration into host DNA
GFB67_04960	COG1132	(ABC) transporter
GFB67_04965	COG2226	methyltransferase
GFB67_04980	COG1959	2 iron, 2 sulfur cluster binding
GFB67_05025	COG0702	epimerase
GFB67_05030	COG1132	(ABC) transporter
GFB67_05045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFB67_05055	COG1132	(ABC) transporter
GFB67_05060	COG1132	(ABC) transporter
GFB67_05070	COG0328	RNA-DNA hybrid ribonuclease activity
GFB67_05100	COG0546	phosphoglycolate phosphatase activity
GFB67_05125	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GFB67_05160	COG1619	proteins homologs of microcin C7 resistance protein MccF
GFB67_05165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFB67_05165	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GFB67_05190	COG2339	peptidase activity
GFB67_05205	COG1174	glycine betaine transport
GFB67_05215	COG1959	2 iron, 2 sulfur cluster binding
GFB67_05230	COG0501	Belongs to the peptidase M48B family
GFB67_05260	COG0586	Pfam SNARE associated Golgi protein
GFB67_05270	COG0017	Asparaginyl-tRNA synthetase
GFB67_05290	COG3250	beta-galactosidase activity
GFB67_05295	COG2190	(PTS) system
GFB67_05295	COG2211	Major facilitator Superfamily
GFB67_05315	COG0110	maltose O-acetyltransferase activity
GFB67_05345	COG2195	Cleaves the N-terminal amino acid of tripeptides
GFB67_05350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GFB67_05355	COG2384	SAM-dependent methyltransferase
GFB67_05390	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GFB67_05400	COG4974	Belongs to the 'phage' integrase family
GFB67_05415	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GFB67_05445	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GFB67_05465	COG2217	Heavy metal translocating P-type atpase
GFB67_05495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFB67_05500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFB67_05505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFB67_05510	COG0358	DNA primase activity
GFB67_05520	COG0752	glycyl-tRNA synthetase alpha subunit
GFB67_05535	COG0295	cytidine deaminase activity
GFB67_05540	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GFB67_05545	COG1702	phosphate starvation-inducible protein PhoH
GFB67_05550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GFB67_05555	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GFB67_05565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFB67_05585	COG0436	Aminotransferase
GFB67_05605	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GFB67_05620	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GFB67_05625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFB67_05630	COG0758	DNA mediated transformation
GFB67_05635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFB67_05640	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GFB67_05650	COG1307	EDD domain protein, DegV family
GFB67_05655	COG1272	protein, Hemolysin III
GFB67_05660	COG0617	tRNA 3'-terminal CCA addition
GFB67_05665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFB67_05690	COG1132	(ABC) transporter
GFB67_05695	COG1132	(ABC) transporter
GFB67_05700	COG0583	DNA-binding transcription factor activity
GFB67_05715	COG1307	EDD domain protein, DegV family
GFB67_05745	COG1126	abc transporter atp-binding protein
GFB67_05750	COG0765	amino acid transport
GFB67_05755	COG0583	DNA-binding transcription factor activity
GFB67_05770	COG0628	permease
GFB67_05775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFB67_05785	COG0640	Transcriptional regulator
GFB67_05795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GFB67_05795	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GFB67_05800	COG3764	Sortase (surface protein transpeptidase)
GFB67_05830	COG0196	riboflavin kinase activity
GFB67_05845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GFB67_05850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GFB67_05885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFB67_05890	COG0626	cystathionine gamma-synthase activity
GFB67_05930	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GFB67_05935	COG0195	Participates in both transcription termination and antitermination
GFB67_05955	COG0750	zinc metalloprotease
GFB67_05960	COG4589	Belongs to the CDS family
GFB67_05965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GFB67_05970	COG0233	cytoplasmic translational termination
GFB67_05990	COG2827	Endonuclease containing a URI domain
GFB67_05995	COG0204	Acyl-transferase
GFB67_06000	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GFB67_06005	COG0527	aspartate kinase activity
GFB67_06010	COG0460	homoserine dehydrogenase
GFB67_06020	COG1132	(ABC) transporter
GFB67_06025	COG1132	(ABC) transporter
GFB67_06030	COG3763	UPF0154 protein
GFB67_06035	COG4224	UPF0291 protein
GFB67_06050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB67_06060	COG1111	helicase
GFB67_06060	COG1205	dead DEAH box helicase
GFB67_06075	COG0737	Belongs to the 5'-nucleotidase family
GFB67_06105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GFB67_06110	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GFB67_06120	COG0552	protein localization to endoplasmic reticulum
GFB67_06125	COG1196	nuclear chromosome segregation
GFB67_06130	COG0571	ribonuclease III activity
GFB67_06145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFB67_06150	COG0601	transmembrane transport
GFB67_06155	COG4608	Belongs to the ABC transporter superfamily
GFB67_06165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFB67_06170	COG0416	fatty acid biosynthetic process
GFB67_06175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFB67_06230	COG1162	GTPase activity
GFB67_06235	COG0515	serine threonine protein kinase
GFB67_06235	COG2815	serine threonine protein kinase
GFB67_06245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFB67_06245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFB67_06255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GFB67_06265	COG0194	GDP metabolic process
GFB67_06290	COG4166	transmembrane transport
GFB67_06295	COG0497	DNA recombination
GFB67_06300	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GFB67_06310	COG1722	exodeoxyribonuclease VII activity
GFB67_06325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFB67_06330	COG1302	Protein conserved in bacteria
GFB67_06335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFB67_06340	COG0006	proline dipeptidase activity
GFB67_06370	COG0151	Belongs to the GarS family
GFB67_06380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GFB67_06400	COG0047	phosphoribosylformylglycinamidine synthase activity
GFB67_06405	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFB67_06410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GFB67_06415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GFB67_06420	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GFB67_06425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GFB67_06450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFB67_06465	COG0477	Major facilitator Superfamily
GFB67_06475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFB67_06485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GFB67_06500	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GFB67_06545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFB67_06560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GFB67_06570	COG0768	penicillin binding
GFB67_06585	COG0072	phenylalanine-tRNA ligase activity
GFB67_06590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GFB67_06595	COG1733	regulation of RNA biosynthetic process
GFB67_06600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFB67_06605	COG1254	Belongs to the acylphosphatase family
GFB67_06610	COG0706	membrane insertase activity
GFB67_06615	COG5002	protein histidine kinase activity
GFB67_06620	COG0745	RESPONSE REGULATOR receiver
GFB67_06635	COG0799	negative regulation of ribosome biogenesis
GFB67_06645	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GFB67_06650	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GFB67_06665	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GFB67_06685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFB67_06690	COG1484	DNA-dependent DNA replication
GFB67_06705	COG0237	dephospho-CoA kinase activity
GFB67_06715	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFB67_06715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFB67_06720	COG0477	Major facilitator Superfamily
GFB67_06750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFB67_06765	COG1131	(ABC) transporter
GFB67_06770	COG0537	adenosine 5'-monophosphoramidase activity
GFB67_06780	COG0167	dihydroorotate dehydrogenase activity
GFB67_06790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GFB67_06795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GFB67_06805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GFB67_06810	COG3481	metal-dependent phosphohydrolase, HD sub domain
GFB67_06815	COG4717	serine-type aminopeptidase activity
GFB67_06820	COG0420	3'-5' exonuclease activity
GFB67_06830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFB67_06835	COG0564	pseudouridine synthase activity
GFB67_06885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GFB67_06890	COG1686	Belongs to the peptidase S11 family
GFB67_06910	COG0574	Belongs to the PEP-utilizing enzyme family
GFB67_06910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GFB67_06915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GFB67_06915	COG0574	Belongs to the PEP-utilizing enzyme family
GFB67_06925	COG0574	Belongs to the PEP-utilizing enzyme family
GFB67_06925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GFB67_06935	COG2244	polysaccharide biosynthetic process
GFB67_06950	COG0671	phosphoesterase, PA-phosphatase related
GFB67_06955	COG0477	Major facilitator Superfamily
GFB67_06960	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GFB67_07020	COG0586	Pfam SNARE associated Golgi protein
GFB67_07030	COG0647	UMP catabolic process
GFB67_07040	COG0737	Belongs to the 5'-nucleotidase family
GFB67_07070	COG0668	transmembrane transport
GFB67_07075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GFB67_07085	COG3118	belongs to the thioredoxin family
GFB67_07090	COG1193	negative regulation of DNA recombination
GFB67_07115	COG0513	Belongs to the DEAD box helicase family
GFB67_07120	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFB67_07125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFB67_07130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GFB67_07150	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GFB67_07170	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GFB67_07175	COG0488	(ABC) transporter
GFB67_07190	COG1214	PFAM Peptidase M22, glycoprotease
GFB67_07210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GFB67_07220	COG0470	DNA polymerase III
GFB67_07225	COG3870	Protein conserved in bacteria
GFB67_07250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GFB67_07260	COG0590	tRNA wobble adenosine to inosine editing
GFB67_07265	COG2813	Specifically methylates the guanine in position
GFB67_07295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GFB67_07350	COG0004	ammonium transporteR
GFB67_07355	COG1215	transferase activity, transferring glycosyl groups
GFB67_07370	COG0250	Participates in transcription elongation, termination and antitermination
GFB67_07410	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GFB67_07430	COG0583	DNA-binding transcription factor activity
GFB67_07450	COG1131	(ABC) transporter
GFB67_07455	COG1725	Transcriptional regulator
GFB67_07460	COG4166	transmembrane transport
GFB67_07465	COG0494	nUDIX hydrolase
GFB67_07495	COG2814	Major facilitator Superfamily
GFB67_07535	COG1012	belongs to the aldehyde dehydrogenase family
GFB67_07535	COG1454	alcohol dehydrogenase
GFB67_07545	COG1122	ATPase activity
GFB67_07555	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GFB67_07560	COG1113	amino acid transport
GFB67_07570	COG1131	(ABC) transporter
GFB67_07635	COG1442	glycosyl transferase family 8
GFB67_07645	COG0756	dUTP diphosphatase activity
GFB67_07670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFB67_07675	COG0588	phosphoglycerate mutase activity
GFB67_07690	COG0588	phosphoglycerate mutase activity
GFB67_07710	COG4948	Mandelate Racemase Muconate Lactonizing
GFB67_07725	COG1737	Transcriptional regulator
GFB67_07780	COG0083	homoserine kinase activity
GFB67_07835	COG0205	6-phosphofructokinase activity
GFB67_07840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFB67_07860	COG0531	amino acid
GFB67_07910	COG2223	nitrite transmembrane transporter activity
GFB67_07930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFB67_07950	COG1113	amino acid transport
GFB67_07965	COG3716	PTS system mannose fructose sorbose family IID component
GFB67_07970	COG3715	PTS system
GFB67_08035	COG0719	Fe-S assembly protein
GFB67_08040	COG0822	iron-sulfur transferase activity
GFB67_08045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GFB67_08050	COG0719	Fe-S assembly protein
GFB67_08055	COG0396	ATPase activity
GFB67_08065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB67_08065	COG1263	PTS System
GFB67_08065	COG2190	(PTS) system
GFB67_08085	COG0577	efflux transmembrane transporter activity
GFB67_08085	COG1136	(ABC) transporter
GFB67_08110	COG0557	exoribonuclease II activity
GFB67_08120	COG1368	sulfuric ester hydrolase activity
GFB67_08130	COG0438	transferase activity, transferring glycosyl groups
GFB67_08135	COG0438	transferase activity, transferring glycosyl groups
GFB67_08330	COG0398	Pfam SNARE associated Golgi protein
GFB67_08350	COG0505	Belongs to the CarA family
GFB67_08370	COG1033	growth of symbiont in host cell
GFB67_08370	COG2409	Drug exporters of the RND superfamily
GFB67_08440	COG1132	(ABC) transporter
GFB67_08455	COG2267	carboxylic ester hydrolase activity
GFB67_08465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFB67_08470	COG1072	(Pantothenic acid kinase))
GFB67_08500	COG3973	AAA domain
GFB67_08520	COG0584	glycerophosphoryl diester phosphodiesterase
GFB67_08550	COG2246	polysaccharide biosynthetic process
GFB67_08565	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GFB67_08570	COG3475	LICD family
GFB67_08580	COG0438	transferase activity, transferring glycosyl groups
GFB67_08595	COG0438	transferase activity, transferring glycosyl groups
GFB67_08600	COG1215	transferase activity, transferring glycosyl groups
GFB67_08610	COG0562	UDP-galactopyranose mutase
GFB67_08620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFB67_08650	COG1396	sequence-specific DNA binding
GFB67_08655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GFB67_08695	COG1122	ATPase activity
GFB67_08700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFB67_08705	COG3093	addiction module antidote protein HigA
GFB67_08710	COG1091	dTDP-4-dehydrorhamnose reductase activity
GFB67_08715	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GFB67_08725	COG1088	dTDP-glucose 4,6-dehydratase activity
GFB67_08730	COG2226	methyltransferase
GFB67_08745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFB67_08750	COG1447	Phosphotransferase system cellobiose-specific component IIA
GFB67_08755	COG0653	protein targeting
GFB67_08805	COG0297	glycogen (starch) synthase activity
GFB67_08805	COG0438	transferase activity, transferring glycosyl groups
GFB67_08840	COG0297	glycogen (starch) synthase activity
GFB67_08850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFB67_08855	COG4464	protein tyrosine phosphatase activity
GFB67_08860	COG0489	protein tyrosine kinase activity
GFB67_08870	COG1316	TRANSCRIPTIONal
GFB67_08875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFB67_08895	COG0791	NLP P60 protein
GFB67_08895	COG1388	LysM domain
GFB67_08905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFB67_08915	COG0194	GDP metabolic process
GFB67_08950	COG0488	(ABC) transporter
GFB67_08960	COG1316	TRANSCRIPTIONal
GFB67_08975	COG1304	FMN binding
GFB67_08985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFB67_08990	COG1121	(ABC) transporter
GFB67_08995	COG0561	phosphatase activity
GFB67_09000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFB67_09000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFB67_09000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB67_09005	COG1105	Belongs to the carbohydrate kinase PfkB family
GFB67_09010	COG1349	DNA-binding transcription factor activity
GFB67_09020	COG1794	racemase activity, acting on amino acids and derivatives
GFB67_09040	COG1132	(ABC) transporter
GFB67_09045	COG1132	(ABC) transporter
GFB67_09055	COG0012	GTP binding
GFB67_09060	COG4481	Protein conserved in bacteria
GFB67_09065	COG1475	DNA binding
GFB67_09070	COG1192	Involved in chromosome partitioning
GFB67_09100	COG0431	NADPH-dependent FMN reductase
GFB67_09105	COG0431	NADPH-dependent FMN reductase
GFB67_09125	COG1131	(ABC) transporter
GFB67_09145	COG3022	response to hydroperoxide
GFB67_09165	COG0778	Nitroreductase
GFB67_09195	COG0471	metal ion transport
GFB67_09200	COG0114	fumarate hydratase activity
GFB67_09230	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GFB67_09245	COG0515	serine threonine protein kinase
GFB67_09260	COG3442	glutamine amidotransferase
GFB67_09275	COG3706	GGDEF domain
GFB67_09300	COG0505	Belongs to the CarA family
GFB67_09305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFB67_09320	COG0167	dihydroorotate dehydrogenase activity
GFB67_09330	COG1278	Cold shock
GFB67_09340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GFB67_09345	COG0697	spore germination
GFB67_09350	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GFB67_09355	COG0561	phosphatase activity
GFB67_09405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GFB67_09410	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFB67_09410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFB67_09420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFB67_09420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFB67_09470	COG1309	transcriptional regulator
GFB67_09475	COG1136	(ABC) transporter
GFB67_09475	COG0577	efflux transmembrane transporter activity
GFB67_09490	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GFB67_09500	COG1696	Membrane protein involved in D-alanine export
GFB67_09505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFB67_09540	COG2217	Heavy metal translocating P-type atpase
GFB67_09560	COG1744	ABC transporter substrate-binding protein PnrA-like
GFB67_09585	COG1744	ABC transporter substrate-binding protein PnrA-like
GFB67_09610	COG1176	ABC-type spermidine putrescine transport system, permease component I
GFB67_09620	COG3842	ATPase activity
GFB67_09635	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GFB67_09640	COG1744	ABC transporter substrate-binding protein PnrA-like
GFB67_09645	COG3845	ABC transporter
GFB67_09650	COG4603	Belongs to the binding-protein-dependent transport system permease family
GFB67_09655	COG1079	Belongs to the binding-protein-dependent transport system permease family
GFB67_09670	COG0656	L-ascorbic acid biosynthetic process
GFB67_09695	COG3409	Peptidoglycan-binding domain 1 protein
GFB67_09705	COG1428	Deoxynucleoside kinase
GFB67_09710	COG1428	Deoxynucleoside kinase
GFB67_09715	COG0765	amino acid transport
GFB67_09720	COG1126	abc transporter atp-binding protein
GFB67_09725	COG2252	PERMEase
GFB67_09750	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GFB67_09755	COG0028	Belongs to the TPP enzyme family
GFB67_09770	COG0706	membrane insertase activity