locus-tag	class	description
G6Z85_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G6Z85_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G6Z85_00025	COG0187	DNA topoisomerase II activity
G6Z85_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G6Z85_00035	COG0360	Binds together with S18 to 16S ribosomal RNA
G6Z85_00040	COG0629	single-stranded DNA binding
G6Z85_00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G6Z85_00055	COG0359	binds to the 23S rRNA
G6Z85_00060	COG0305	Participates in initiation and elongation during chromosome replication
G6Z85_00090	COG4555	ABC transporter
G6Z85_00160	COG1285	pathogenesis
G6Z85_00190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G6Z85_00195	COG0038	chloride channel
G6Z85_00205	COG2252	PERMEase
G6Z85_00210	COG1744	ABC transporter substrate-binding protein PnrA-like
G6Z85_00215	COG1744	ABC transporter substrate-binding protein PnrA-like
G6Z85_00240	COG3104	oligopeptide transport
G6Z85_00245	COG0363	glucosamine-6-phosphate deaminase activity
G6Z85_00250	COG1428	Deoxynucleoside kinase
G6Z85_00255	COG1428	Deoxynucleoside kinase
G6Z85_00260	COG2252	PERMEase
G6Z85_00290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G6Z85_00295	COG1696	Membrane protein involved in D-alanine export
G6Z85_00300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G6Z85_00305	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
G6Z85_00315	COG1136	(ABC) transporter
G6Z85_00320	COG0531	amino acid
G6Z85_00355	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G6Z85_00365	COG0515	serine threonine protein kinase
G6Z85_00370	COG1131	(ABC) transporter
G6Z85_00385	COG2274	protein secretion by the type I secretion system
G6Z85_00430	COG3715	PTS system
G6Z85_00435	COG3716	PTS system mannose fructose sorbose family IID component
G6Z85_00445	COG1113	amino acid transport
G6Z85_00455	COG2502	aspartate--ammonia ligase
G6Z85_00465	COG1511	domain protein
G6Z85_00475	COG0531	amino acid
G6Z85_00480	COG3442	glutamine amidotransferase
G6Z85_00485	COG2365	Tyrosine phosphatase family
G6Z85_00490	COG1609	Transcriptional regulator
G6Z85_00495	COG0366	Alpha amylase catalytic
G6Z85_00510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G6Z85_00515	COG3842	ATPase activity
G6Z85_00525	COG1175	transmembrane transport
G6Z85_00530	COG3833	ABC-type maltose transport systems, permease component
G6Z85_00550	COG0431	NADPH-dependent FMN reductase
G6Z85_00555	COG0431	NADPH-dependent FMN reductase
G6Z85_00575	COG1475	DNA binding
G6Z85_00580	COG1192	Involved in chromosome partitioning
G6Z85_00585	COG1475	DNA binding
G6Z85_00590	COG4481	Protein conserved in bacteria
G6Z85_00595	COG0012	GTP binding
G6Z85_00605	COG1335	isochorismatase
G6Z85_00620	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G6Z85_00625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G6Z85_00635	COG1105	Belongs to the carbohydrate kinase PfkB family
G6Z85_00650	COG0588	phosphoglycerate mutase activity
G6Z85_00655	COG1078	dGTPase activity
G6Z85_00665	COG3343	RNA polymerase activity
G6Z85_00670	COG0504	CTP synthase activity
G6Z85_00675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G6Z85_00680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G6Z85_00685	COG1132	(ABC) transporter
G6Z85_00705	COG0194	GDP metabolic process
G6Z85_00735	COG0049	tRNA binding
G6Z85_00740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G6Z85_00745	COG3973	AAA domain
G6Z85_00750	COG1072	(Pantothenic acid kinase))
G6Z85_00755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G6Z85_00760	COG2195	Cleaves the N-terminal amino acid of tripeptides
G6Z85_00770	COG2971	BadF BadG BcrA BcrD
G6Z85_00800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G6Z85_00810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G6Z85_00810	COG1263	PTS System
G6Z85_00825	COG1263	PTS System
G6Z85_00825	COG2190	(PTS) system
G6Z85_00825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G6Z85_00845	COG0745	RESPONSE REGULATOR receiver
G6Z85_00855	COG0573	inorganic phosphate transmembrane transporter activity
G6Z85_00860	COG0581	inorganic phosphate transmembrane transporter activity
G6Z85_00870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G6Z85_01070	COG0438	transferase activity, transferring glycosyl groups
G6Z85_01075	COG0438	transferase activity, transferring glycosyl groups
G6Z85_01085	COG1368	sulfuric ester hydrolase activity
G6Z85_01120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G6Z85_01125	COG2814	Major facilitator Superfamily
G6Z85_01130	COG0495	leucyl-tRNA aminoacylation
G6Z85_01135	COG2244	polysaccharide biosynthetic process
G6Z85_01140	COG0588	phosphoglycerate mutase activity
G6Z85_01160	COG3775	system Galactitol-specific IIC component
G6Z85_01170	COG0235	Class ii aldolase
G6Z85_01185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G6Z85_01250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G6Z85_01260	COG1686	Belongs to the peptidase S11 family
G6Z85_01265	COG0018	arginyl-trna synthetase
G6Z85_01275	COG0564	pseudouridine synthase activity
G6Z85_01280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G6Z85_01290	COG0420	3'-5' exonuclease activity
G6Z85_01295	COG4717	serine-type aminopeptidase activity
G6Z85_01300	COG3481	metal-dependent phosphohydrolase, HD sub domain
G6Z85_01305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G6Z85_01315	COG0537	adenosine 5'-monophosphoramidase activity
G6Z85_01320	COG1131	(ABC) transporter
G6Z85_01335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G6Z85_01340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6Z85_01345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G6Z85_01355	COG4555	ABC transporter
G6Z85_01375	COG0542	response to heat
G6Z85_01385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G6Z85_01405	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G6Z85_01430	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G6Z85_01435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G6Z85_01440	COG3715	PTS system
G6Z85_01455	COG0366	Alpha amylase catalytic
G6Z85_01465	COG1447	Phosphotransferase system cellobiose-specific component IIA
G6Z85_01470	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G6Z85_01470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G6Z85_01475	COG2723	6-phospho-beta-galactosidase activity
G6Z85_01480	COG3684	Belongs to the aldolase LacD family
G6Z85_01485	COG1349	DNA-binding transcription factor activity
G6Z85_01495	COG0698	ribose 5-phosphate isomerase
G6Z85_01510	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
G6Z85_01515	COG1461	Dihydroxyacetone kinase
G6Z85_01520	COG2376	Dihydroxyacetone kinase
G6Z85_01525	COG1164	Oligoendopeptidase f
G6Z85_01530	COG1316	TRANSCRIPTIONal
G6Z85_01565	COG2813	Specifically methylates the guanine in position
G6Z85_01570	COG0590	tRNA wobble adenosine to inosine editing
G6Z85_01580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G6Z85_01585	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G6Z85_01600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G6Z85_01610	COG4467	Involved in initiation control of chromosome replication
G6Z85_01625	COG1214	PFAM Peptidase M22, glycoprotease
G6Z85_01635	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G6Z85_01640	COG0745	RESPONSE REGULATOR receiver
G6Z85_01645	COG5002	protein histidine kinase activity
G6Z85_01650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G6Z85_01660	COG1418	mRNA catabolic process
G6Z85_01665	COG0477	Major facilitator Superfamily
G6Z85_01675	COG1418	mRNA catabolic process
G6Z85_01800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G6Z85_01805	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G6Z85_01810	COG1131	(ABC) transporter
G6Z85_01820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G6Z85_01825	COG0588	phosphoglycerate mutase activity
G6Z85_01830	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G6Z85_01835	COG0284	orotidine-5'-phosphate decarboxylase activity
G6Z85_01840	COG2814	Major facilitator Superfamily
G6Z85_01845	COG0167	dihydroorotate dehydrogenase activity
G6Z85_01865	COG0505	Belongs to the CarA family
G6Z85_01870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G6Z85_01890	COG0488	(ABC) transporter
G6Z85_01915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G6Z85_01920	COG0632	four-way junction helicase activity
G6Z85_01930	COG1862	Preprotein translocase
G6Z85_01935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G6Z85_01945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G6Z85_01950	COG0513	Belongs to the DEAD box helicase family
G6Z85_01955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G6Z85_01965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G6Z85_01975	COG1193	negative regulation of DNA recombination
G6Z85_01980	COG3118	belongs to the thioredoxin family
G6Z85_01990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G6Z85_01995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G6Z85_02000	COG0668	transmembrane transport
G6Z85_02015	COG0006	proline dipeptidase activity
G6Z85_02030	COG0584	glycerophosphoryl diester phosphodiesterase
G6Z85_02045	COG0647	UMP catabolic process
G6Z85_02060	COG0586	Pfam SNARE associated Golgi protein
G6Z85_02065	COG0492	ferredoxin-NADP+ reductase activity
G6Z85_02090	COG1113	amino acid transport
G6Z85_02095	COG1012	belongs to the aldehyde dehydrogenase family
G6Z85_02095	COG1454	alcohol dehydrogenase
G6Z85_02100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G6Z85_02105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G6Z85_02110	COG3842	ATPase activity
G6Z85_02115	COG1175	transmembrane transport
G6Z85_02120	COG0395	ABC-type sugar transport system, permease component
G6Z85_02145	COG0561	phosphatase activity
G6Z85_02150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G6Z85_02155	COG0280	phosphate acetyltransferase
G6Z85_02160	COG0802	atpase or kinase
G6Z85_02165	COG2176	DNA-directed DNA polymerase activity
G6Z85_02175	COG3842	ATPase activity
G6Z85_02185	COG1177	transmembrane transport
G6Z85_02205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G6Z85_02210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G6Z85_02220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G6Z85_02225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G6Z85_02250	COG0402	S-adenosylhomocysteine deaminase activity
G6Z85_02255	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G6Z85_02280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G6Z85_02290	COG4537	Required for transformation and DNA binding
G6Z85_02310	COG0827	DNA restriction-modification system
G6Z85_02325	COG4974	Belongs to the 'phage' integrase family
G6Z85_02600	COG1129	ABC transporter
G6Z85_02605	COG0366	Alpha amylase catalytic
G6Z85_02620	COG4120	Belongs to the binding-protein-dependent transport system permease family
G6Z85_02625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G6Z85_02630	COG2814	Major facilitator Superfamily
G6Z85_02635	COG1122	ATPase activity
G6Z85_02650	COG2814	Major facilitator Superfamily
G6Z85_02665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6Z85_02670	COG0765	amino acid transport
G6Z85_02675	COG0765	amino acid transport
G6Z85_02680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G6Z85_02695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G6Z85_02700	COG0416	fatty acid biosynthetic process
G6Z85_02705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G6Z85_02715	COG4608	Belongs to the ABC transporter superfamily
G6Z85_02720	COG0601	transmembrane transport
G6Z85_02735	COG0571	ribonuclease III activity
G6Z85_02740	COG1196	nuclear chromosome segregation
G6Z85_02745	COG0552	protein localization to endoplasmic reticulum
G6Z85_02760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G6Z85_02765	COG1278	Cold shock
G6Z85_02770	COG0494	nUDIX hydrolase
G6Z85_02780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G6Z85_02785	COG1104	cysteine desulfurase activity
G6Z85_02795	COG0302	gtp cyclohydrolase
G6Z85_02795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G6Z85_02800	COG0302	gtp cyclohydrolase
G6Z85_02810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G6Z85_02815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G6Z85_02830	COG1121	(ABC) transporter
G6Z85_02850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G6Z85_02855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G6Z85_02860	COG0006	proline dipeptidase activity
G6Z85_02865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G6Z85_02875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G6Z85_02885	COG1570	exodeoxyribonuclease VII activity
G6Z85_02900	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
G6Z85_02905	COG0497	DNA recombination
G6Z85_02915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G6Z85_02920	COG0228	four-way junction DNA binding
G6Z85_02925	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G6Z85_02930	COG0336	Belongs to the RNA methyltransferase TrmD family
G6Z85_02950	COG4224	UPF0291 protein
G6Z85_02955	COG3763	UPF0154 protein
G6Z85_02960	COG1132	(ABC) transporter
G6Z85_02965	COG1132	(ABC) transporter
G6Z85_02970	COG0204	Acyl-transferase
G6Z85_02975	COG2827	Endonuclease containing a URI domain
G6Z85_02990	COG0528	UMP kinase activity
G6Z85_02995	COG0233	cytoplasmic translational termination
G6Z85_03000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G6Z85_03005	COG4589	Belongs to the CDS family
G6Z85_03010	COG0750	zinc metalloprotease
G6Z85_03015	COG0442	prolyl-tRNA aminoacylation
G6Z85_03020	COG2176	DNA-directed DNA polymerase activity
G6Z85_03025	COG0779	Required for maturation of 30S ribosomal subunits
G6Z85_03030	COG0195	Participates in both transcription termination and antitermination
G6Z85_03035	COG2740	Nucleic-acid-binding protein implicated in transcription termination
G6Z85_03050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G6Z85_03055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G6Z85_03060	COG0196	riboflavin kinase activity
G6Z85_03175	COG1420	regulation of RNA biosynthetic process
G6Z85_03180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G6Z85_03185	COG0443	Heat shock 70 kDa protein
G6Z85_03190	COG0484	heat shock protein binding
G6Z85_03195	COG0481	GTPase activity
G6Z85_03200	COG3764	Sortase (surface protein transpeptidase)
G6Z85_03205	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G6Z85_03205	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
G6Z85_03220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G6Z85_03245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G6Z85_03260	COG0242	peptide deformylase activity
G6Z85_03270	COG0772	Belongs to the SEDS family
G6Z85_03280	COG0742	ribosomal rna small subunit methyltransferase
G6Z85_03285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G6Z85_03290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G6Z85_03295	COG1596	polysaccharide export
G6Z85_03295	COG1555	photosystem II stabilization
G6Z85_03300	COG0658	competence protein
G6Z85_03300	COG2333	competence protein COMEC
G6Z85_03305	COG1466	dna polymerase III delta subunit
G6Z85_03310	COG0268	Binds directly to 16S ribosomal RNA
G6Z85_03315	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G6Z85_03355	COG1760	l-serine dehydratase
G6Z85_03360	COG1760	l-serine dehydratase
G6Z85_03365	COG2151	metal-sulfur cluster biosynthetic enzyme
G6Z85_03390	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G6Z85_03390	COG2755	lipolytic protein G-D-S-L family
G6Z85_03400	COG0300	oxidoreductase activity
G6Z85_03415	COG0587	DNA-directed DNA polymerase activity
G6Z85_03420	COG0205	6-phosphofructokinase activity
G6Z85_03430	COG2996	Protein conserved in bacteria
G6Z85_03450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G6Z85_03455	COG1187	pseudouridine synthase activity
G6Z85_03470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G6Z85_03475	COG0539	negative regulation of cytoplasmic translation
G6Z85_03480	COG1160	GTP binding
G6Z85_03500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G6Z85_03510	COG1272	protein, Hemolysin III
G6Z85_03515	COG1307	EDD domain protein, DegV family
G6Z85_03520	COG4479	Belongs to the UPF0346 family
G6Z85_03525	COG0793	Belongs to the peptidase S41A family
G6Z85_03540	COG0758	DNA mediated transformation
G6Z85_03545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G6Z85_03575	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G6Z85_03580	COG0187	DNA topoisomerase II activity
G6Z85_03590	COG1227	inorganic diphosphatase activity
G6Z85_03600	COG1307	EDD domain protein, DegV family
G6Z85_03610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G6Z85_03615	COG0505	Belongs to the CarA family
G6Z85_03620	COG0564	pseudouridine synthase activity
G6Z85_03625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G6Z85_03630	COG2759	Belongs to the formate--tetrahydrofolate ligase family
G6Z85_03640	COG0116	Belongs to the methyltransferase superfamily
G6Z85_03650	COG3599	regulation of cell shape
G6Z85_03655	COG4474	Belongs to the UPF0398 family
G6Z85_03660	COG3331	DNA recombination
G6Z85_03670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G6Z85_03680	COG0017	Asparaginyl-tRNA synthetase
G6Z85_03690	COG1199	ATP-dependent helicase activity
G6Z85_03690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G6Z85_03695	COG1074	ATP-dependent DNA helicase activity
G6Z85_03700	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
G6Z85_03720	COG1304	FMN binding
G6Z85_03725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G6Z85_03725	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
G6Z85_03770	COG1137	ATPase activity
G6Z85_03775	COG1725	Transcriptional regulator
G6Z85_03780	COG2195	Cleaves the N-terminal amino acid of tripeptides
G6Z85_03790	COG2384	SAM-dependent methyltransferase
G6Z85_03795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G6Z85_03800	COG0358	DNA primase activity
G6Z85_03805	COG0751	glycine-tRNA ligase activity
G6Z85_03815	COG1381	Involved in DNA repair and RecF pathway recombination
G6Z85_03820	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G6Z85_03830	COG1702	phosphate starvation-inducible protein PhoH
G6Z85_03840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G6Z85_03850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G6Z85_03855	COG0431	NADPH-dependent FMN reductase
G6Z85_03860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G6Z85_03865	COG0124	histidyl-tRNA synthetase
G6Z85_03870	COG1490	D-aminoacyl-tRNA deacylase activity
G6Z85_03875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G6Z85_03885	COG2264	protein methyltransferase activity
G6Z85_03890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G6Z85_03910	COG0488	(ABC) transporter
G6Z85_03915	COG1523	belongs to the glycosyl hydrolase 13 family
G6Z85_03920	COG0148	phosphopyruvate hydratase activity
G6Z85_03940	COG1523	belongs to the glycosyl hydrolase 13 family
G6Z85_03950	COG1125	glycine betaine transport
G6Z85_03955	COG2814	Major facilitator Superfamily
G6Z85_03990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G6Z85_04005	COG0308	aminopeptidase N
G6Z85_04010	COG2936	dipeptidyl-peptidase activity
G6Z85_04015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G6Z85_04020	COG1285	pathogenesis
G6Z85_04025	COG3716	PTS system mannose fructose sorbose family IID component
G6Z85_04030	COG3715	PTS system
G6Z85_04045	COG3933	PFAM sigma-54 factor interaction domain-containing protein
G6Z85_04045	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
G6Z85_04050	COG0768	penicillin binding
G6Z85_04055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G6Z85_04060	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G6Z85_04065	COG0072	phenylalanine-tRNA ligase activity
G6Z85_04070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G6Z85_04075	COG1733	regulation of RNA biosynthetic process
G6Z85_04080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G6Z85_04085	COG0706	membrane insertase activity
G6Z85_04090	COG5002	protein histidine kinase activity
G6Z85_04095	COG0745	RESPONSE REGULATOR receiver
G6Z85_04105	COG1323	Belongs to the UPF0348 family
G6Z85_04110	COG0799	negative regulation of ribosome biogenesis
G6Z85_04115	COG1713	HD superfamily hydrolase involved in NAD metabolism
G6Z85_04120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G6Z85_04125	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G6Z85_04130	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
G6Z85_04135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G6Z85_04135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G6Z85_04135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G6Z85_04140	COG1105	Belongs to the carbohydrate kinase PfkB family
G6Z85_04145	COG1349	DNA-binding transcription factor activity
G6Z85_04150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G6Z85_04160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G6Z85_04170	COG1484	DNA-dependent DNA replication
G6Z85_04175	COG3611	Membrane attachment protein
G6Z85_04185	COG0237	dephospho-CoA kinase activity
G6Z85_04190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G6Z85_04195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G6Z85_04195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G6Z85_04205	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G6Z85_04210	COG1253	flavin adenine dinucleotide binding
G6Z85_04225	COG2137	regulation of response to DNA damage stimulus
G6Z85_04230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G6Z85_04245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G6Z85_04255	COG0024	Methionine aminopeptidase
G6Z85_04260	COG0716	FMN binding
G6Z85_04265	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G6Z85_04280	COG0513	Belongs to the DEAD box helicase family
G6Z85_04290	COG1253	flavin adenine dinucleotide binding
G6Z85_04310	COG0446	pyridine nucleotide-disulphide oxidoreductase
G6Z85_04315	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
G6Z85_04320	COG2188	Transcriptional regulator
G6Z85_04330	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G6Z85_04340	COG3830	Belongs to the UPF0237 family
G6Z85_04360	COG0719	Fe-S assembly protein
G6Z85_04365	COG0822	iron-sulfur transferase activity
G6Z85_04370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G6Z85_04375	COG0719	Fe-S assembly protein
G6Z85_04385	COG1392	Phosphate transport regulator
G6Z85_04390	COG0306	phosphate transporter
G6Z85_04395	COG1126	abc transporter atp-binding protein
G6Z85_04400	COG0765	amino acid transport
G6Z85_04405	COG0572	uridine kinase
G6Z85_04410	COG1564	THIamine pyrophosphokinase
G6Z85_04415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G6Z85_04425	COG0515	serine threonine protein kinase
G6Z85_04425	COG2815	serine threonine protein kinase
G6Z85_04435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G6Z85_04435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G6Z85_04445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G6Z85_04450	COG1758	RNA polymerase activity
G6Z85_04455	COG0194	GDP metabolic process
G6Z85_04470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G6Z85_04480	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G6Z85_04485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G6Z85_04535	COG1792	Involved in formation and maintenance of cell shape
G6Z85_04540	COG1077	Cell shape determining protein MreB Mrl
G6Z85_04545	COG2003	Belongs to the UPF0758 family
G6Z85_04550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G6Z85_04560	COG0525	valine-tRNA ligase activity
G6Z85_04570	COG1104	cysteine desulfurase activity
G6Z85_04575	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
G6Z85_04585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G6Z85_04640	COG0791	NLP P60 protein
G6Z85_04640	COG0741	lytic transglycosylase activity
G6Z85_04680	COG1674	ftsk spoiiie
G6Z85_04695	COG0772	Belongs to the SEDS family
G6Z85_04705	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G6Z85_04710	COG1077	Cell shape determining protein MreB Mrl
G6Z85_04730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G6Z85_04745	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G6Z85_04750	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G6Z85_04755	COG0356	it plays a direct role in the translocation of protons across the membrane
G6Z85_04765	COG0009	L-threonylcarbamoyladenylate synthase
G6Z85_04770	COG2890	protein-(glutamine-N5) methyltransferase activity
G6Z85_04775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G6Z85_04780	COG1435	thymidine kinase activity
G6Z85_04785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G6Z85_04790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G6Z85_04805	COG1668	transmembrane transport
G6Z85_04810	COG4152	abc transporter atp-binding protein
G6Z85_04820	COG1368	sulfuric ester hydrolase activity
G6Z85_04825	COG0745	RESPONSE REGULATOR receiver
G6Z85_04835	COG1482	cell wall glycoprotein biosynthetic process
G6Z85_04845	COG0577	efflux transmembrane transporter activity
G6Z85_04850	COG1136	(ABC) transporter
G6Z85_04855	COG2205	protein histidine kinase activity
G6Z85_04860	COG0745	RESPONSE REGULATOR receiver
G6Z85_04865	COG1653	transport
G6Z85_04895	COG4886	Leucine-rich repeat (LRR) protein
G6Z85_04895	COG4932	domain protein
G6Z85_05075	COG0494	nUDIX hydrolase
G6Z85_05180	COG2801	Transposase and inactivated derivatives
G6Z85_05245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G6Z85_05260	COG1376	ErfK ybiS ycfS ynhG family protein
G6Z85_05265	COG1597	lipid kinase activity
G6Z85_05280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G6Z85_05285	COG4851	CamS sex pheromone cAM373 precursor
G6Z85_05290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G6Z85_05300	COG1705	Flagellar rod assembly protein muramidase FlgJ
G6Z85_05315	COG0516	GMP reductase activity
G6Z85_05315	COG0517	IMP dehydrogenase activity
G6Z85_05330	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G6Z85_05350	COG2244	polysaccharide biosynthetic process
G6Z85_05355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
G6Z85_05370	COG2188	Transcriptional regulator
G6Z85_05395	COG3425	synthase
G6Z85_05405	COG0183	Belongs to the thiolase family
G6Z85_05420	COG1114	Component of the transport system for branched-chain amino acids
G6Z85_05440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G6Z85_05445	COG1121	(ABC) transporter
G6Z85_05450	COG3443	Belongs to the bacterial solute-binding protein 9 family
G6Z85_05450	COG0803	Belongs to the bacterial solute-binding protein 9 family
G6Z85_05455	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
G6Z85_05460	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G6Z85_05465	COG0557	exoribonuclease II activity
G6Z85_05495	COG2390	Transcriptional regulator
G6Z85_05505	COG0740	serine-type endopeptidase activity
G6Z85_05525	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G6Z85_05535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G6Z85_05540	COG0556	nucleotide-excision repair
G6Z85_05545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G6Z85_05550	COG0492	ferredoxin-NADP+ reductase activity
G6Z85_05555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G6Z85_05565	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G6Z85_05580	COG0653	protein targeting
G6Z85_05590	COG1040	competence protein
G6Z85_05595	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
G6Z85_05600	COG1739	Uncharacterized protein family UPF0029
G6Z85_05605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G6Z85_05610	COG1418	mRNA catabolic process
G6Z85_05615	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G6Z85_05620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G6Z85_05625	COG1426	Protein conserved in bacteria
G6Z85_05630	COG0612	Peptidase, M16
G6Z85_05640	COG1674	ftsk spoiiie
G6Z85_05655	COG0628	permease
G6Z85_05665	COG2706	6-phosphogluconolactonase activity
G6Z85_05675	COG0564	pseudouridine synthase activity
G6Z85_05680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G6Z85_05685	COG2357	RelA SpoT domain protein
G6Z85_05705	COG4862	establishment of competence for transformation
G6Z85_05710	COG1393	Belongs to the ArsC family
G6Z85_05770	COG3158	transport of potassium into the cell
G6Z85_05775	COG1473	amidohydrolase
G6Z85_05785	COG1121	(ABC) transporter
G6Z85_05790	COG0561	phosphatase activity
G6Z85_05795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G6Z85_05810	COG0542	response to heat
G6Z85_05815	COG0436	Aminotransferase
G6Z85_05840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G6Z85_05845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G6Z85_05870	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G6Z85_05875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G6Z85_05880	COG0193	aminoacyl-tRNA hydrolase activity
G6Z85_05885	COG0039	L-malate dehydrogenase activity
G6Z85_05895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G6Z85_05900	COG0736	holo-[acyl-carrier-protein] synthase activity
G6Z85_05910	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G6Z85_05955	COG0519	Catalyzes the synthesis of GMP from XMP
G6Z85_05965	COG2233	PERMEase
G6Z85_05975	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G6Z85_05985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G6Z85_05990	COG0250	Participates in transcription elongation, termination and antitermination
G6Z85_06020	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
G6Z85_06025	COG0215	cysteine-tRNA ligase activity
G6Z85_06030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G6Z85_06040	COG0756	dUTP diphosphatase activity
G6Z85_06055	COG0588	phosphoglycerate mutase activity
G6Z85_06070	COG1230	cation diffusion facilitator family transporter
G6Z85_06100	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G6Z85_06105	COG0101	tRNA pseudouridine synthase activity
G6Z85_06110	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G6Z85_06115	COG1122	ATPase activity
G6Z85_06150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G6Z85_06155	COG0563	adenylate kinase activity
G6Z85_06170	COG1841	ribosomal large subunit assembly
G6Z85_06185	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G6Z85_06200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G6Z85_06205	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G6Z85_06220	COG0255	Belongs to the universal ribosomal protein uL29 family
G6Z85_06230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G6Z85_06235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G6Z85_06245	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G6Z85_06255	COG0088	Forms part of the polypeptide exit tunnel
G6Z85_06260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G6Z85_06270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G6Z85_06280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G6Z85_06285	COG4466	Protein conserved in bacteria
G6Z85_06290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G6Z85_06295	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
G6Z85_06300	COG0084	hydrolase, TatD family'
G6Z85_06305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6Z85_06305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6Z85_06320	COG2131	deaminase
G6Z85_06340	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G6Z85_06345	COG1121	(ABC) transporter
G6Z85_06355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G6Z85_06375	COG3590	peptidase
G6Z85_06380	COG2814	Major facilitator Superfamily
G6Z85_06385	COG0602	queuosine metabolic process
G6Z85_06390	COG1328	CTP reductase activity
G6Z85_06400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G6Z85_06420	COG0446	pyridine nucleotide-disulphide oxidoreductase
G6Z85_06430	COG0367	asparagine synthase
G6Z85_06445	COG0589	response to stress
G6Z85_06450	COG2365	Tyrosine phosphatase family
G6Z85_06455	COG4555	ABC transporter
G6Z85_06505	COG2801	Transposase and inactivated derivatives
G6Z85_06525	COG1396	sequence-specific DNA binding
G6Z85_06565	COG2801	Transposase and inactivated derivatives
G6Z85_06585	COG1181	Belongs to the D-alanine--D-alanine ligase family
G6Z85_06615	COG0537	adenosine 5'-monophosphoramidase activity
G6Z85_06630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G6Z85_06640	COG1216	Glycosyl transferase, family 2
G6Z85_06650	COG0328	RNA-DNA hybrid ribonuclease activity
G6Z85_06660	COG0765	amino acid transport
G6Z85_06665	COG1126	abc transporter atp-binding protein
G6Z85_06670	COG1132	(ABC) transporter
G6Z85_06690	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G6Z85_06695	COG1704	LemA family
G6Z85_06700	COG0501	Belongs to the peptidase M48B family
G6Z85_06710	COG1122	ATPase activity
G6Z85_06725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G6Z85_06730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G6Z85_06745	COG5002	protein histidine kinase activity
G6Z85_06750	COG0745	RESPONSE REGULATOR receiver
G6Z85_06760	COG2233	PERMEase
G6Z85_06765	COG0402	S-adenosylhomocysteine deaminase activity
G6Z85_06780	COG2267	carboxylic ester hydrolase activity
G6Z85_06785	COG1114	Component of the transport system for branched-chain amino acids
G6Z85_06790	COG0531	amino acid
G6Z85_06795	COG0708	Exodeoxyribonuclease III
G6Z85_06800	COG1011	Hydrolase
G6Z85_06815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G6Z85_06820	COG1780	Probably involved in ribonucleotide reductase function
G6Z85_06835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G6Z85_06840	COG0706	membrane insertase activity
G6Z85_06845	COG0594	ribonuclease P activity
G6Z85_06850	COG0230	Belongs to the bacterial ribosomal protein bL34 family