locus-tag class description FEM46_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FEM46_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FEM46_00015 ENOG410848D S4 domain protein YaaA FEM46_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FEM46_00025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FEM46_00035 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FEM46_00040 ENOG4108UUM single-stranded DNA-binding protein FEM46_00045 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FEM46_00055 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FEM46_00060 ENOG4105CDU Replicative dna helicase FEM46_00065 ENOG410605W Major Facilitator FEM46_00070 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FEM46_00075 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FEM46_00080 ENOG4108J59 Extracellular solute-binding protein, family 5 FEM46_00085 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FEM46_00090 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FEM46_00100 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FEM46_00110 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FEM46_00120 ENOG4107URF beta-phospho-glucomutase FEM46_00125 ENOG4105C71 hydrolase family 65, central catalytic FEM46_00135 ENOG4105VEQ Cold shock protein FEM46_00250 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FEM46_00255 ENOG4105BZU Histidine kinase FEM46_00270 ENOG4105Q2H domain protein FEM46_00275 ENOG4105C0H protease FEM46_00280 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FEM46_00290 ENOG4107RGH Aldehyde dehydrogenase FEM46_00295 ENOG4108HFV FEM46_00300 ENOG4108RG0 uracil-dna glycosylase FEM46_00320 ENOG4107EFR Flavocytochrome c FEM46_00325 ENOG4107QPK )-transporter FEM46_00340 ENOG4108UXE Protein tyrosine phosphatase FEM46_00345 ENOG4105DTD Dehydrogenase FEM46_00355 ENOG4108TVJ Nitroreductase FEM46_00360 ENOG4105G9B Transcriptional regulator FEM46_00370 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FEM46_00375 ENOG4107QHE Choloylglycine hydrolase FEM46_00385 ENOG4105M2Z protein tyrosine serine phosphatase FEM46_00390 ENOG4105EFA 4-hydroxyphenylacetate FEM46_00410 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FEM46_00445 ENOG4105CIS alcohol dehydrogenase FEM46_00470 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) FEM46_00475 ENOG4105D1Q UPF0246 protein FEM46_00485 ENOG4108J59 Extracellular solute-binding protein, family 5 FEM46_00510 ENOG4108JJB ABC transporter FEM46_00515 ENOG41082M7 Cobalt transport protein FEM46_00520 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) FEM46_00525 ENOG4105TV1 Transcriptional regulator FEM46_00530 ENOG4105QUH Domain of unknown function (DUF2088) FEM46_00535 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase FEM46_00550 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FEM46_00555 ENOG4105DVM PP-loop domain protein FEM46_00560 ENOG4105CIS alcohol dehydrogenase FEM46_00565 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FEM46_00570 ENOG4105DWF phosphomethylpyrimidine kinase FEM46_00575 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FEM46_00585 ENOG4108Z86 Glutamine amidotransferase FEM46_00620 ENOG41067S9 phage shock protein C, PspC FEM46_00660 ENOG4105DJ2 Major Facilitator Superfamily FEM46_00670 ENOG4107S5I aldo keto reductase FEM46_00700 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FEM46_00705 ENOG4108JJB ABC transporter FEM46_00710 ENOG4108V7D UPF0397 protein FEM46_00720 ENOG4108TZY GntR Family Transcriptional Regulator FEM46_00745 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FEM46_00750 ENOG4105CIG ABC transporter FEM46_00765 ENOG4105C10 Electron transfer flavoprotein FEM46_00770 ENOG4105X71 Membrane FEM46_00780 ENOG4105CMT Dihydroxyacetone kinase FEM46_00785 ENOG4105CMT Dihydroxyacetone kinase FEM46_00790 ENOG4108UTZ Dihydroxyacetone kinase FEM46_00795 ENOG4105VDH Dihydroxyacetone kinase FEM46_00800 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FEM46_00810 ENOG4105FKQ transcriptional regulator FEM46_00815 ENOG4105CG3 alpha amylase, catalytic region FEM46_00820 ENOG4107FKK extracellular solute-binding protein family 1 FEM46_00825 ENOG4105D56 permease protein FEM46_00830 ENOG4105EG2 ABC transporter, permease FEM46_00840 ENOG4107S9Q Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) FEM46_00845 ENOG4108IJ9 (ABC) transporter FEM46_00870 ENOG4105EVU fructokinase FEM46_00875 ENOG4105DME alpha-galactosidase FEM46_00880 ENOG4105C5Y PTS System FEM46_00885 ENOG4108HKT sucrose-6-phosphate hydrolase FEM46_00890 ENOG4105ETE Transcriptional regulator (LacI family FEM46_00905 ENOG4105DFD Na H antiporter FEM46_00915 ENOG4105C5Q Transcriptional regulator FEM46_00945 ENOG4108JQ1 Dehydrogenase FEM46_00950 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FEM46_00955 ENOG4105CVJ phosphoglycerate mutase FEM46_00960 ENOG4105CPC Aldo Keto reductase FEM46_00975 ENOG4105F23 Fibronectin-binding protein FEM46_00980 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FEM46_00990 ENOG4106A8V Protein CrcB homolog FEM46_01010 ENOG4108JJB ABC transporter FEM46_01020 ENOG4108V06 Glutathione peroxidase FEM46_01030 ENOG4105KP9 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FEM46_01045 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FEM46_01050 ENOG4105DZW Dipeptidase FEM46_01055 ENOG4105CTS PTS system mannitol-specific FEM46_01065 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FEM46_01070 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FEM46_01080 ENOG4105K63 Thioredoxin FEM46_01110 ENOG4108YYH Nadph-dependent fmn reductase FEM46_01120 ENOG4105C28 cystathionine FEM46_01125 ENOG4105C6T cysteine synthase FEM46_01130 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FEM46_01155 ENOG4107414 GntR family transcriptional regulator FEM46_01160 ENOG4105CG3 alpha amylase, catalytic region FEM46_01165 ENOG4105C5Y PTS System FEM46_01170 ENOG4105C5Y PTS System FEM46_01180 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FEM46_01185 ENOG41062SP FEM46_01190 ENOG4108Z40 Transcriptional regulator FEM46_01195 ENOG4105MKU Transcriptional regulator FEM46_01200 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FEM46_01220 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEM46_01230 ENOG4105GR3 Histidine kinase FEM46_01235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FEM46_01250 ENOG4105CK1 PTS System FEM46_01265 ENOG4108KGH TRANSCRIPTIONal FEM46_01270 ENOG4105CQB FAD linked oxidase domain protein FEM46_01290 ENOG4105EYF MMPL domain protein FEM46_01290 ENOG4105EYF MMPL domain protein FEM46_01295 ENOG4108R3E Dna-3-methyladenine glycosylase i FEM46_01305 ENOG4107WD8 ABC transporter, permease FEM46_01325 ENOG4106770 Is able to cleave peptidoglycan (By similarity) FEM46_01330 ENOG41068JE domain protein FEM46_01360 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FEM46_01370 ENOG4108U05 Transcriptional regulator FEM46_01375 ENOG4105CEP NADH dehydrogenase FEM46_01400 ENOG4108HM4 ABC transporter FEM46_01415 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FEM46_01445 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FEM46_01450 ENOG4105CZV ABC transporter FEM46_01460 ENOG4108EKI Dehydrogenase FEM46_01485 ENOG4105DZW Dipeptidase FEM46_01495 ENOG41080Y5 BioY family FEM46_01510 ENOG4105D01 (LipO)protein FEM46_01520 ENOG4108UMI ABC transporter, permease FEM46_01525 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FEM46_01545 ENOG4105EY8 ABC transporter FEM46_01560 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEM46_01565 ENOG4105BZU Histidine kinase FEM46_01585 ENOG4105E66 phosphoriboisomerase A FEM46_01595 ENOG4105KA3 membrAne FEM46_01600 ENOG4105KIS phospholipid-binding protein FEM46_01625 ENOG4105DU0 nucleoside hydrolase FEM46_01630 ENOG4105E1F short-chain dehydrogenase reductase FEM46_01640 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FEM46_01650 ENOG4108IJ8 ABC transporter FEM46_01660 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FEM46_01665 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FEM46_01670 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FEM46_01760 ENOG4108UW5 maltose o-acetyltransferase FEM46_01770 ENOG4108HCJ Hydrolase FEM46_01775 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) FEM46_01780 ENOG410667J hydrolase FEM46_01785 ENOG4105CWM branched-chain amino acid transport system II carrier protein FEM46_01830 ENOG4107R0E Glycosyl transferase, family 2 FEM46_01855 ENOG4108WCX response regulator FEM46_01880 ENOG4108JJA ABC, transporter FEM46_01915 ENOG4105VDM plasmid maintenance system antidote protein, xre family FEM46_01920 ENOG4105EEM helicase FEM46_01925 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FEM46_01930 ENOG4105C31 Tryptophanyl-tRNA synthetase FEM46_01935 ENOG4108S3Y transcriptional regulator FEM46_01940 ENOG4105CK1 PTS System FEM46_01955 ENOG4105CK1 PTS System FEM46_01960 ENOG4105CS2 ec 3.2.1.21 FEM46_01965 ENOG4105DKQ ROK family FEM46_01990 ENOG4105C9X ppx gppa phosphatase FEM46_02005 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FEM46_02010 ENOG4105I3N Conserved Protein FEM46_02020 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FEM46_02025 ENOG4105C2C drug resistance transporter, Bcr CflA FEM46_02030 ENOG4105F8V Hydrolase, tatD family FEM46_02035 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FEM46_02040 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FEM46_02045 ENOG4105W42 Veg protein FEM46_02050 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FEM46_02065 ENOG4105FDK ABC transporter FEM46_02070 ENOG4105CC5 ABC transporter FEM46_02100 ENOG4105DFT pur operon repressor FEM46_02105 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FEM46_02115 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FEM46_02135 ENOG4105DCI Phosphohydrolase FEM46_02140 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FEM46_02150 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) FEM46_02155 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FEM46_02160 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FEM46_02165 ENOG4105C44 Serine transporter FEM46_02180 ENOG4105EJQ L-serine dehydratase FEM46_02195 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FEM46_02200 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FEM46_02205 ENOG41082DI 50s ribosomal protein l31 FEM46_02215 ENOG4108Z6X (sortase) family FEM46_02220 ENOG4108V0P LemA family FEM46_02225 ENOG4105D0M Protease HtpX homolog FEM46_02235 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FEM46_02240 ENOG4105C1J atp-dependent rna helicase FEM46_02250 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FEM46_02255 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FEM46_02260 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FEM46_02265 ENOG4105DFH Transport of potassium into the cell (By similarity) FEM46_02290 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FEM46_02295 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FEM46_02300 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FEM46_02305 ENOG4105CAS nag kinase FEM46_02310 ENOG4105C8Y Acetylornithine aminotransferase FEM46_02315 ENOG4105DBV ornithine carbamoyltransferase FEM46_02335 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FEM46_02340 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FEM46_02345 ENOG4108JA2 transcriptioN-repair coupling factor FEM46_02355 ENOG41082I2 s4 domain protein FEM46_02365 ENOG41060GV RNA binding s1 domain protein FEM46_02370 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FEM46_02385 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FEM46_02395 ENOG4105CRK lysyL-tRNA synthetase FEM46_02435 ENOG4105DUX Transporter FEM46_02480 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FEM46_02485 ENOG4105II7 pyrroline-5-carboxylate reductase FEM46_02495 ENOG4105FDP GntR family transcriptional regulator FEM46_02505 ENOG4105DAP Nicotinate phosphoribosyltransferase FEM46_02510 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FEM46_02530 ENOG410906U SprT-like FEM46_02535 ENOG4105D6E homoserine dehydrogenase FEM46_02540 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FEM46_02580 ENOG4105ETZ PTS System FEM46_02585 ENOG4105F3R pts system mannose fructose sorbose family iid FEM46_02595 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FEM46_02600 ENOG4108EQA pts system FEM46_02605 ENOG4108EQA pts system FEM46_02610 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FEM46_02620 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FEM46_02630 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FEM46_02635 ENOG4108KGH TRANSCRIPTIONal FEM46_02645 ENOG4108TVT permease FEM46_02650 ENOG4108K79 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FEM46_02660 ENOG4105CTZ aminopeptidase c FEM46_02665 ENOG4105E66 phosphoriboisomerase A FEM46_02675 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FEM46_02700 ENOG4105CTP PilT protein domain protein FEM46_02705 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FEM46_02710 ENOG4105C8N cysteinyl-tRNA synthetase FEM46_02715 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) FEM46_02720 ENOG4105C2N RNA methyltransferase TrmH family group 3 FEM46_02735 ENOG4107FTN 50S ribosomal protein L33 FEM46_02745 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FEM46_02755 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FEM46_02760 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FEM46_02765 ENOG4108VZM 50s ribosomal protein L10 FEM46_02770 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FEM46_02795 ENOG4108URH decarboxylase FEM46_02805 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FEM46_02810 ENOG41067VN Glutaredoxin FEM46_02815 ENOG4107Y49 methyltransferase FEM46_02830 ENOG4105C6E dna polymerase iii FEM46_02835 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FEM46_02840 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FEM46_02850 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FEM46_02855 ENOG4105X0R protein from nitrogen regulatory protein P-II FEM46_02860 ENOG4105FA2 dna polymerase iii FEM46_02865 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) FEM46_02870 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FEM46_02880 ENOG4105CMR udp-glucose 4-epimerase FEM46_02885 ENOG4107STF Involved in phosphonate degradation (By similarity) FEM46_02890 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FEM46_02895 ENOG4105S7S phosphonate abc transporter FEM46_02905 ENOG4105D5T phosphonate abc transporter FEM46_02915 ENOG41072GX Peptidase M22 Glycoprotease FEM46_02920 ENOG41080E2 ribosomal-protein-alanine acetyltransferase FEM46_02925 ENOG410801F ribosomal-protein-alanine acetyltransferase FEM46_02930 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FEM46_02940 ENOG4105C5H ABC transporter FEM46_02945 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FEM46_02955 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FEM46_02960 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FEM46_02965 ENOG4105C0X amino acid FEM46_02970 ENOG4105ESV Glycosyl transferase, family 4 FEM46_02975 ENOG4105CVA phosphate FEM46_02980 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FEM46_03000 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FEM46_03015 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FEM46_03020 ENOG4105BZU Histidine kinase FEM46_03025 ENOG4105CVA phosphate FEM46_03030 ENOG4105C8U phosphate abc transporter FEM46_03035 ENOG4105E2Z phosphate ABC transporter (Permease FEM46_03040 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FEM46_03045 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FEM46_03050 ENOG4108UTW Plays a role in the regulation of phosphate uptake FEM46_03055 ENOG41067S9 phage shock protein C, PspC FEM46_03060 ENOG41086DT Membrane protein of unknown function FEM46_03065 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FEM46_03070 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FEM46_03075 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FEM46_03090 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FEM46_03110 ENOG4107R8N Glycosyl transferase, family 2 FEM46_03125 ENOG4105C3M thioredoxin reductase FEM46_03130 ENOG4105H67 Protein of unknown function (DUF421) FEM46_03150 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FEM46_03170 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FEM46_03175 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FEM46_03180 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FEM46_03185 ENOG4105CDH Citrulline--aspartate ligase FEM46_03190 ENOG4105CH7 arginosuccinase FEM46_03200 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FEM46_03205 ENOG4105CHW UPF0052 protein FEM46_03210 ENOG4105CIE May be required for sporulation (By similarity) FEM46_03215 ENOG4107QSI ABC, transporter FEM46_03220 ENOG4105C5I Dehydrogenase FEM46_03225 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FEM46_03235 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FEM46_03245 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FEM46_03250 ENOG4105BZA Phosphoglycerate kinase FEM46_03255 ENOG4105CP7 Triose-phosphate isomerase FEM46_03260 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FEM46_03275 ENOG4105CMQ Chloride channel FEM46_03280 ENOG4105XZU Preprotein translocase, subunit SecG FEM46_03290 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FEM46_03295 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FEM46_03305 ENOG4105E5Q amino acid AbC transporter FEM46_03310 ENOG4105CDA abc transporter atp-binding protein FEM46_03325 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FEM46_03330 ENOG4108IJ2 phosphate acetyltransferase FEM46_03335 ENOG4105K8N protein family UPF0079, ATPase FEM46_03345 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FEM46_03350 ENOG4105CGK Exodeoxyribonuclease III FEM46_03355 ENOG4105EP9 oxidoreductase FEM46_03360 ENOG4105D4A Cell wall formation (By similarity) FEM46_03365 ENOG4107SUZ Sodium/hydrogen exchanger family FEM46_03390 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FEM46_03395 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FEM46_03405 ENOG4108HCJ Hydrolase FEM46_03415 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FEM46_03430 ENOG4108DBC nitroreductase FEM46_03450 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FEM46_03465 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FEM46_03480 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEM46_03485 ENOG4105D49 3-dehydroquinate synthase FEM46_03490 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FEM46_03500 ENOG4105KPE licD family FEM46_03515 ENOG4105C7N Xanthine uracil vitamin C permease FEM46_03520 ENOG4105C7K acetolactate synthase FEM46_03525 ENOG4105DTN riboflavin biosynthesis protein ribF FEM46_03530 ENOG4105C7K acetolactate synthase FEM46_03545 ENOG4105EXC Acyl-transferase FEM46_03550 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FEM46_03565 ENOG4105CUB amino acid FEM46_03580 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FEM46_03590 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FEM46_03595 ENOG4105G5W regulator Fur family FEM46_03610 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FEM46_03615 ENOG4105CHM Aminotransferase FEM46_03620 ENOG4105C5I Dehydrogenase FEM46_03640 ENOG4105CT1 (ABC) transporter FEM46_03645 ENOG4105EAD ABC transporter FEM46_03650 ENOG4105DRP amino acid AbC transporter FEM46_03655 ENOG4105CI1 PTS System FEM46_03665 ENOG4105C5Y PTS System FEM46_03670 ENOG410901P UPF0249 protein FEM46_03675 ENOG4107R7I amino acid FEM46_03685 ENOG4105K56 Transcriptional regulator FEM46_03715 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FEM46_03725 ENOG4105KPY Small multidrug resistance protein FEM46_03740 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FEM46_03750 ENOG4105RHY Pfam:UPF0157 FEM46_03755 ENOG4105DQR SNARE associated Golgi FEM46_03760 ENOG4105EEM helicase FEM46_03765 ENOG4105EA8 2-Nitropropane dioxygenase FEM46_03770 ENOG4105CS9 pantothenic acid kinase FEM46_03775 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FEM46_03785 ENOG4108IMY Transcriptional regulator FEM46_03800 ENOG4105KVH Transcriptional regulator FEM46_03805 ENOG4105FCW Major Facilitator superfamily FEM46_03845 ENOG4105EXC Acyl-transferase FEM46_03850 ENOG4107BMA Transglycosylase associated protein FEM46_03865 ENOG4105VBF alkaline shock protein FEM46_03895 ENOG4105CD8 aminopeptidase N FEM46_03915 ENOG4105DQ6 Transposase FEM46_03945 ENOG4105DBI uridine monophosphokinase FEM46_03960 ENOG4107RSM transcriptional regulator FEM46_03965 ENOG4107EFR Flavocytochrome c FEM46_03975 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FEM46_03980 ENOG4105C5S asparaginyl-tRNA synthetase FEM46_03985 ENOG4105CU9 asparagine synthetase A FEM46_03990 ENOG4105DZW Dipeptidase FEM46_04010 ENOG4105C9U ATP-dependent DNA helicase RecQ FEM46_04015 ENOG4105EMS pseudouridine synthase FEM46_04020 ENOG41082BM Transcriptional regulator, arsr family FEM46_04070 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FEM46_04080 ENOG4105CAQ asparagine synthetase FEM46_04155 ENOG4105DWK Membrane FEM46_04165 ENOG4108KGH TRANSCRIPTIONal FEM46_04185 ENOG41062ES Transcriptional regulator FEM46_04195 ENOG4108IQI permease FEM46_04205 ENOG4105ZMH deoxynucleoside kinase FEM46_04210 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FEM46_04250 ENOG4105KEX transcriptional regulator, ctsr FEM46_04255 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FEM46_04260 ENOG41062JF Transcriptional regulator FEM46_04265 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FEM46_04270 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FEM46_04275 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) FEM46_04280 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FEM46_04285 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FEM46_04290 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FEM46_04295 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FEM46_04300 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FEM46_04305 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FEM46_04310 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FEM46_04315 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FEM46_04320 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FEM46_04325 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FEM46_04330 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FEM46_04335 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FEM46_04340 ENOG41082SA 50s ribosomal protein l29 FEM46_04345 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FEM46_04350 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FEM46_04355 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FEM46_04360 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FEM46_04365 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FEM46_04370 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FEM46_04375 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FEM46_04380 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FEM46_04385 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FEM46_04390 ENOG41084KY 50S ribosomal protein L30 FEM46_04395 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FEM46_04400 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FEM46_04405 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FEM46_04410 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FEM46_04415 ENOG41067V7 50S ribosomal protein L36 FEM46_04420 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FEM46_04425 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FEM46_04430 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FEM46_04435 ENOG4108ZT0 50S ribosomal protein l17 FEM46_04460 ENOG41088B0 Major membrane immunogen FEM46_04470 ENOG4108JJB ABC transporter FEM46_04475 ENOG4108JJB ABC transporter FEM46_04485 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FEM46_04490 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FEM46_04495 ENOG4108UJD 30S ribosomal protein S9 FEM46_04515 ENOG4105CV1 Transketolase (EC 2.2.1.1) FEM46_04520 ENOG4105E2X shikimate dehydrogenase FEM46_04525 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase FEM46_04530 ENOG4105D49 3-dehydroquinate synthase FEM46_04540 ENOG4105VG1 fes assembly suf system protein FEM46_04545 ENOG4107GFK fumarate FEM46_04550 ENOG4106DSS Tartrate dehydratase subunit alpha FEM46_04555 ENOG4105ID8 Transcriptional regulator, ARAC family FEM46_04560 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase FEM46_04565 ENOG4105DIK (ABC) transporter FEM46_04570 ENOG4105CC5 ABC transporter FEM46_04575 ENOG4105DSE periplasmic solute binding protein FEM46_04585 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FEM46_04590 ENOG4107QPK )-transporter FEM46_04610 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) FEM46_04630 ENOG4105C9Q fumarate hydratase class II FEM46_04635 ENOG4107EFR Flavocytochrome c FEM46_04645 ENOG4105CMU LysR family (Transcriptional regulator FEM46_04650 ENOG4107ZGM malolactic fermentation system FEM46_04655 ENOG4105C6K Malic enzyme FEM46_04665 ENOG4105CUB amino acid FEM46_04685 ENOG4105C4M (Ubiquinol oxidase) subunit I FEM46_04690 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FEM46_04695 ENOG4108JJ9 ABC, transporter FEM46_04700 ENOG4108JJ8 (ABC) transporter FEM46_04730 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FEM46_04735 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FEM46_04740 ENOG4108U5N UPF0316 protein FEM46_04745 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FEM46_04750 ENOG4105C4R Atp-dependent dna helicase FEM46_04755 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FEM46_04765 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FEM46_04770 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FEM46_04775 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FEM46_04780 ENOG4105CBD Diacylglycerol kinase FEM46_04785 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FEM46_04800 ENOG4105CK1 PTS System FEM46_04810 ENOG4106KNT transcriptional regulator FEM46_04825 ENOG4105VEQ Cold shock protein FEM46_04830 ENOG4105EE0 oxidoreductase FEM46_04835 ENOG4105FDU atp-dependent rna helicase FEM46_04850 ENOG4105CK1 PTS System FEM46_04875 ENOG4107R37 Glutamate dehydrogenase FEM46_04885 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FEM46_04895 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FEM46_04900 ENOG4105D5D udp-galactopyranose mutase FEM46_04925 ENOG4107YYJ Glycosyl transferase, family 2 FEM46_04955 ENOG4105D5G Transposase FEM46_04965 ENOG4105D5D udp-galactopyranose mutase FEM46_05000 ENOG4105T16 Transcriptional regulator (AraC family) FEM46_05025 ENOG4105D3Q Sugar transferase FEM46_05060 ENOG410902V Modulates RecA activity (By similarity) FEM46_05065 ENOG4105EVI UPF0374 protein FEM46_05070 ENOG4105K4H Nlp p60 protein FEM46_05085 ENOG4108A04 Beta-lactamase FEM46_05095 ENOG4105C02 permease FEM46_05100 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase FEM46_05105 ENOG4105C6Z Gluconate FEM46_05110 ENOG4105CMG Carbohydrate kinase FEM46_05120 ENOG4105DC8 reductase FEM46_05125 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FEM46_05165 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FEM46_05170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FEM46_05180 ENOG4108JQ7 (ABC) transporter FEM46_05195 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FEM46_05205 ENOG4105KRI phosphocarrier protein (HPr FEM46_05210 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FEM46_05215 ENOG4105BZF Glycosyl transferase (Group 1 FEM46_05220 ENOG4105W2C Glycosyl transferase FEM46_05235 ENOG4105CHM Aminotransferase FEM46_05240 ENOG4107IN1 Protein of unknown function (DUF1797) FEM46_05245 ENOG4105E0M Sulfatase FEM46_05335 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FEM46_05355 ENOG4108R1E Serine threonine protein phosphatase 1 FEM46_05365 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FEM46_05370 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FEM46_05375 ENOG4108IQI permease FEM46_05380 ENOG4107QK5 Homocysteine s-methyltransferase FEM46_05385 ENOG4105Q84 sucrose synthase FEM46_05395 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FEM46_05400 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEM46_05440 ENOG4105C8T Leucyl-tRNA synthetase FEM46_05455 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FEM46_05460 ENOG4107QSE Dipeptidase FEM46_05470 ENOG4108IJ9 (ABC) transporter FEM46_05475 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FEM46_05480 ENOG4105DRS transport system, permease FEM46_05490 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FEM46_05495 ENOG4105ZMH deoxynucleoside kinase FEM46_05500 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FEM46_05505 ENOG4105ECB domain protein FEM46_05505 ENOG4105ECB domain protein FEM46_05525 ENOG4108NEV two component transcriptional regulator, LytTR family FEM46_05535 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FEM46_05540 ENOG4105VUF Transcriptional regulator FEM46_05550 ENOG4108UZ3 Transporter FEM46_05555 ENOG410667J hydrolase FEM46_05575 ENOG4108WCX response regulator FEM46_05595 ENOG4105K56 Transcriptional regulator FEM46_05610 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FEM46_05655 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FEM46_05665 ENOG4107RIQ Sulfate adenylate transferase FEM46_05670 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FEM46_05675 ENOG4105SFS phosphoesterase RecJ domain protein FEM46_05710 ENOG4107YB6 acetyltransferase, (GNAT) family FEM46_05715 ENOG4105C75 arginyL-tRNA synthetase FEM46_05725 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FEM46_05740 ENOG4105S7A ErfK ybiS ycfS ynhG family protein FEM46_05750 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FEM46_05760 ENOG4105CHM Aminotransferase FEM46_05765 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FEM46_05775 ENOG4105BZ4 penicillin-binding protein FEM46_05780 ENOG4105WZB UPF0342 protein FEM46_05785 ENOG4107VRP DNA repair exonuclease FEM46_05790 ENOG4106D4I domain protein FEM46_05795 ENOG4105EQI Metal Dependent Phosphohydrolase FEM46_05810 ENOG4105C5Q Transcriptional regulator FEM46_05825 ENOG4107EFR Flavocytochrome c FEM46_05845 ENOG41062D9 Histidine kinase FEM46_05850 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FEM46_05860 ENOG4105CKK Glycosyl transferase, family 2 FEM46_05865 ENOG4105DQR SNARE associated Golgi FEM46_05895 ENOG4108R6K riboflavin synthase, subunit alpha FEM46_05900 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FEM46_05905 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FEM46_05920 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FEM46_05930 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FEM46_05960 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FEM46_05970 ENOG4105K59 histidine triad (HIT) protein FEM46_05985 ENOG4108V15 phosphotransferase enzyme family FEM46_05990 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FEM46_06025 ENOG4108IMY Transcriptional regulator FEM46_06035 ENOG4106050 phage regulatory protein, rha family FEM46_06240 ENOG4108VDD TRNA binding domain protein FEM46_06250 ENOG4105DFU Cell wall formation (By similarity) FEM46_06275 ENOG4105JRK feS assembly protein SufD FEM46_06285 ENOG4108UNV SUF system FeS assembly protein, NifU family FEM46_06290 ENOG4105DIW FeS assembly protein SUFB FEM46_06300 ENOG4105E0A ABC, transporter FEM46_06305 ENOG4105EHG Permease protein FEM46_06325 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FEM46_06335 ENOG4105VG1 fes assembly suf system protein FEM46_06360 ENOG4105WH1 Two component transcriptional regulator luxr family FEM46_06385 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FEM46_06390 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b FEM46_06395 ENOG4105CVM Molybdenum cofactor synthesis domain protein FEM46_06400 ENOG4105EPU Molybdenum cofactor synthesis domain protein FEM46_06405 ENOG4105D06 uba thif-type nad fad binding protein FEM46_06415 ENOG4108IUE nitrate reductase beta subunit FEM46_06425 ENOG4105D0D Nitrate reductase 2, gamma subunit FEM46_06465 ENOG4105C2M dna polymerase I FEM46_06470 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FEM46_06475 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FEM46_06480 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FEM46_06495 ENOG4105C22 threonyL-tRNA synthetase FEM46_06500 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FEM46_06505 ENOG4105VJV 50s ribosomal protein L35 FEM46_06510 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FEM46_06520 ENOG4105D1H recombination factor protein RarA FEM46_06525 ENOG4105CIS alcohol dehydrogenase FEM46_06530 ENOG4105KVH Transcriptional regulator FEM46_06540 ENOG4105CND Glycosyl transferase, family 2 FEM46_06555 ENOG4105CQW ribosome biogenesis GTPase YqeH FEM46_06560 ENOG410812S Rna-binding protein FEM46_06565 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FEM46_06570 ENOG4108WF2 Metal Dependent Phosphohydrolase FEM46_06575 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FEM46_06580 ENOG4105DXX methyltransferase FEM46_06585 ENOG4105CDE UPF0348 protein FEM46_06595 ENOG41067VY 50S ribosomal protein L32 FEM46_06610 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FEM46_06615 ENOG4105D1H recombination factor protein RarA FEM46_06620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FEM46_06625 ENOG4105GR3 Histidine kinase FEM46_06635 ENOG4105EYH Exonuclease FEM46_06650 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) FEM46_06655 ENOG410855V Acylphosphatase FEM46_06660 ENOG4108RWN rrna methyltransferase FEM46_06675 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FEM46_06680 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FEM46_06690 ENOG4105DBI uridine monophosphokinase FEM46_06695 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FEM46_06710 ENOG4105W8X HesB YadR YfhF-family protein FEM46_06720 ENOG4107RF6 penicillin-binding protein FEM46_06725 ENOG4105WDJ 50S ribosomal protein L33 FEM46_06730 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FEM46_06735 ENOG4107ZXI Rhomboid family FEM46_06745 ENOG4105DKQ ROK family FEM46_06765 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FEM46_06770 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FEM46_06775 ENOG4105KV4 Transcriptional regulator FEM46_06780 ENOG4105C5F glutamine synthetase FEM46_06825 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FEM46_06835 ENOG4105K46 50S ribosomal protein l27 FEM46_06840 ENOG4105DC7 peptidase M24 FEM46_06845 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FEM46_06850 ENOG4108ZSR alkaline shock protein FEM46_06855 ENOG4105M7K Involved in the transcription termination process (By similarity) FEM46_06860 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FEM46_06865 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FEM46_06870 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FEM46_06875 ENOG4105CTB Polyprenyl synthetase FEM46_06880 ENOG4105DX0 Hemolysin A FEM46_06885 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FEM46_06890 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FEM46_06905 ENOG4108HQR Glycine betaine FEM46_06910 ENOG4105R40 Glycine betaine carnitine choline FEM46_06920 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FEM46_06925 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FEM46_06930 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FEM46_06935 ENOG4105C25 Primosomal protein n' FEM46_06940 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FEM46_06945 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FEM46_06950 ENOG4108ZF3 Phosphatase FEM46_06955 ENOG4105D9P serine threonine protein kinase FEM46_06960 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FEM46_06965 ENOG4105DJV ribulose-phosphate 3-epimerase FEM46_06970 ENOG4105FJ0 thiamine FEM46_06980 ENOG4105VB9 50S ribosomal protein l28 FEM46_06985 ENOG4108ZAA Alkaline-shock protein FEM46_06990 ENOG4105DP4 dak2 domain fusion protein ylov FEM46_06995 ENOG4105CB5 ATP-dependent DNA helicase recG FEM46_07000 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FEM46_07005 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FEM46_07010 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FEM46_07015 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FEM46_07020 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FEM46_07025 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) FEM46_07030 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FEM46_07035 ENOG4105K5M 30s ribosomal protein S16 FEM46_07040 ENOG4105VB6 UPF0109 protein FEM46_07045 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FEM46_07050 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FEM46_07055 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FEM46_07090 ENOG4105DDQ anthranilate synthase FEM46_07095 ENOG4108I0Q anthranilate phosphoribosyltransferase FEM46_07100 ENOG4105DK0 Indole-3-glycerol phosphate synthase FEM46_07105 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FEM46_07110 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FEM46_07115 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FEM46_07140 ENOG4105CPQ Dehydrogenase FEM46_07150 ENOG4105E1F short-chain dehydrogenase reductase FEM46_07160 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FEM46_07165 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FEM46_07170 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FEM46_07175 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FEM46_07180 ENOG4105CHR reductase FEM46_07185 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FEM46_07195 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FEM46_07200 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FEM46_07215 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FEM46_07225 ENOG4108UQV Membrane FEM46_07230 ENOG4105DUM transcriptional regulator, lysR family FEM46_07235 ENOG4108S4H thioesterase Superfamily protein FEM46_07240 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FEM46_07255 ENOG4105C57 major facilitator superfamily FEM46_07295 ENOG4108M1A Chitin-binding protein FEM46_07300 ENOG41067V3 Antibiotic biosynthesis monooxygenase FEM46_07310 ENOG4105KAV tspo and mbr like protein FEM46_07320 ENOG4105KAF membrAne FEM46_07325 ENOG4105CBD Diacylglycerol kinase FEM46_07340 ENOG4107BMA Transglycosylase associated protein FEM46_07345 ENOG4106EMP CsbD-like FEM46_07355 ENOG4105DZW Dipeptidase FEM46_07360 ENOG41069HH 4-oxalocrotonate tautomerase FEM46_07395 ENOG4108JPW Aminotransferase FEM46_07400 ENOG4105CUB amino acid FEM46_07405 ENOG4108KP7 hydrolase FEM46_07410 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FEM46_07430 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FEM46_07435 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FEM46_07460 ENOG4105DVT helicase FEM46_07475 ENOG4105C5S asparaginyl-tRNA synthetase FEM46_07490 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FEM46_07495 ENOG4108UMI ABC transporter, permease FEM46_07510 ENOG4105D38 putrescine abc transporter FEM46_07515 ENOG4107QKW extracellular solute-binding protein family 1 FEM46_07530 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FEM46_07535 ENOG4108UKS UPF0398 protein FEM46_07540 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) FEM46_07550 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FEM46_07555 ENOG4108MXZ Esterase FEM46_07565 ENOG4105K64 Glycosyl transferase, family 2 FEM46_07585 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FEM46_07610 ENOG4107VFR oxidoreductase FEM46_07625 ENOG4105CKU formyltetrahydrofolate synthetase FEM46_07630 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FEM46_07635 ENOG4105C34 Pseudouridine synthase FEM46_07640 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FEM46_07645 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FEM46_07650 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FEM46_07665 ENOG4108ZMX Domain of unknown function (DU1801) FEM46_07690 ENOG4105CJ1 ABC, transporter FEM46_07695 ENOG4108TU7 Inherit from COG: (ABC) transporter FEM46_07700 ENOG4105F23 Fibronectin-binding protein FEM46_07710 ENOG4105EPR degv family FEM46_07770 ENOG4105C85 amino acid FEM46_07785 ENOG4105DAA L-lactate FEM46_07795 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FEM46_07820 ENOG4105K56 Transcriptional regulator FEM46_07825 ENOG4107QN2 dihydrolipoyl dehydrogenase FEM46_07855 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FEM46_07860 ENOG4105E0X reductase FEM46_07865 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FEM46_07870 ENOG4105DND Transcriptional regulator FEM46_07880 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FEM46_07885 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FEM46_07895 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FEM46_07900 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FEM46_07905 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FEM46_07910 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FEM46_07915 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FEM46_07920 ENOG4105C79 DNA protecting protein DprA FEM46_07925 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FEM46_07930 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FEM46_07945 ENOG4107RSM transcriptional regulator FEM46_07975 ENOG4105VSD UPF0346 protein FEM46_07980 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) FEM46_07985 ENOG41090WU lipolytic protein G-D-S-L family FEM46_07990 ENOG4108RCR degv family FEM46_07995 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FEM46_08000 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FEM46_08005 ENOG4105C5H ABC transporter FEM46_08015 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FEM46_08020 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FEM46_08025 ENOG4108HCJ Hydrolase FEM46_08030 ENOG41068YB TPR repeat-containing protein FEM46_08045 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FEM46_08050 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FEM46_08055 ENOG4105CAT Cytidine monophosphate kinase FEM46_08065 ENOG4105C9U ATP-dependent DNA helicase RecQ FEM46_08075 ENOG4108SAX Membrane FEM46_08080 ENOG4105FE9 pseudouridine synthase FEM46_08085 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FEM46_08090 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FEM46_08100 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FEM46_08105 ENOG4105QNR S1 RNA binding domain protein FEM46_08115 ENOG4105CA9 Pyruvate kinase FEM46_08120 ENOG4105CTQ phosphohexokinase FEM46_08125 ENOG4105C0B DNA polymerase III (alpha subunit) FEM46_08135 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FEM46_08140 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FEM46_08145 ENOG4105EGD dinuclear metal center protein, YbgI family FEM46_08190 ENOG41082F9 transcriptional regulator FEM46_08210 ENOG4105C59 p-type ATPase FEM46_08220 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEM46_08230 ENOG4107PP3 Acetylornithine deacetylase FEM46_08235 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FEM46_08240 ENOG4105E98 transcriptional regulator DeoR family FEM46_08250 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FEM46_08270 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FEM46_08300 ENOG4108W5M transcriptional regulator FEM46_08305 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FEM46_08315 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FEM46_08320 ENOG4108S01 response regulator FEM46_08325 ENOG4108ZGX Histidine kinase FEM46_08335 ENOG4108M15 ABC transporter FEM46_08345 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FEM46_08360 ENOG4105CJ1 ABC, transporter FEM46_08380 ENOG4105CZV ABC transporter FEM46_08385 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FEM46_08395 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FEM46_08400 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FEM46_08405 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FEM46_08410 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FEM46_08415 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) FEM46_08420 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FEM46_08425 ENOG4107YR5 Diacylglycerol kinase FEM46_08430 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FEM46_08435 ENOG4105C9A Phoh family FEM46_08440 ENOG4105KTH gatB Yqey FEM46_08445 ENOG4105VCC 30S ribosomal protein S21 FEM46_08450 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FEM46_08455 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FEM46_08460 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FEM46_08470 ENOG4107AYK membrAne FEM46_08475 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FEM46_08480 ENOG4105C9M aspartyl-trna synthetase FEM46_08485 ENOG4105CUT histidyl-tRNA synthetase FEM46_08490 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FEM46_08500 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FEM46_08505 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FEM46_08510 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FEM46_08520 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FEM46_08525 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FEM46_08530 ENOG4108VX5 3-methyladenine DNA glycosylase FEM46_08545 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FEM46_08550 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FEM46_08555 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) FEM46_08560 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FEM46_08565 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) FEM46_08575 ENOG4105FQP Beta-lactamase FEM46_08580 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FEM46_08585 ENOG4105CFG Acts as a chaperone (By similarity) FEM46_08590 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FEM46_08595 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FEM46_08600 ENOG4107FQX Alpha-acetolactate decarboxylase FEM46_08605 ENOG4105DTN riboflavin biosynthesis protein ribF FEM46_08610 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FEM46_08625 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FEM46_08635 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FEM46_08640 ENOG4105EMV Major Facilitator FEM46_08645 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FEM46_08650 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FEM46_08660 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FEM46_08665 ENOG4105CHV Transcription elongation factor NusA FEM46_08670 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FEM46_08675 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FEM46_08680 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FEM46_08685 ENOG4105DZP Membrane-associated zinc metalloprotease FEM46_08690 ENOG4105KNE Phosphatidate cytidylyltransferase FEM46_08695 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FEM46_08700 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FEM46_08705 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FEM46_08710 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FEM46_08715 ENOG4105CE9 30S ribosomal protein S2 FEM46_08725 ENOG4105C5I Dehydrogenase FEM46_08730 ENOG4105VC4 domain protein FEM46_08735 ENOG41060K3 Methyltransferase FEM46_08740 ENOG4105F6E Acyl-transferase FEM46_08745 ENOG4105VXM UPF0154 protein FEM46_08750 ENOG4105VPS UPF0291 protein FEM46_08755 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FEM46_08770 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase FEM46_08785 ENOG4105CKK Glycosyl transferase, family 2 FEM46_08850 ENOG4105K8R UPF0145 protein FEM46_08865 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FEM46_08870 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FEM46_08875 ENOG41067VP Protein of unknown function (DUF1049) FEM46_08880 ENOG4108IXY short-chain dehydrogenase reductase FEM46_08885 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FEM46_08895 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FEM46_08900 ENOG4105E98 transcriptional regulator DeoR family FEM46_08905 ENOG4105DE4 1-phosphofructokinase FEM46_08910 ENOG4105DM4 PTS System FEM46_08915 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FEM46_08925 ENOG4108RYC glycosyltransferase FEM46_08940 ENOG4107QPH glycogen) synthase FEM46_08950 ENOG4108IAJ Nad-dependent epimerase dehydratase FEM46_08960 ENOG4108QV3 biosynthesis protein FEM46_08970 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FEM46_08975 ENOG4105CDA abc transporter atp-binding protein FEM46_08980 ENOG4105EAD ABC transporter FEM46_09000 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FEM46_09005 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FEM46_09010 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FEM46_09015 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FEM46_09030 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FEM46_09040 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FEM46_09045 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FEM46_09050 ENOG4105TQK DNA polymerase iii, delta' subunit FEM46_09055 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FEM46_09060 ENOG4108UK2 deaminase FEM46_09065 ENOG4105KQC Competence protein FEM46_09070 ENOG41063PX domain protein FEM46_09075 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FEM46_09080 ENOG4106H78 methyltransferase FEM46_09085 ENOG4105WUC UPF0298 protein FEM46_09090 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FEM46_09095 ENOG4105CNI cell division protein FtsW FEM46_09130 ENOG4105CI3 gtp-binding protein typa FEM46_09135 ENOG4105ECY inositol monophosphatase FEM46_09140 ENOG4105WBI UPF0223 protein FEM46_09145 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FEM46_09170 ENOG4107RUY (E1 component), alpha subunit FEM46_09175 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FEM46_09185 ENOG4106EHS UPF0356 protein FEM46_09190 ENOG4105CN5 Metallo-Beta-Lactamase FEM46_09205 ENOG41069ER domain protein FEM46_09210 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FEM46_09215 ENOG4105C7H Helicase, RecD TraA family FEM46_09225 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FEM46_09245 ENOG4107ZYR domain protein FEM46_09255 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FEM46_09265 ENOG4105C3J Cysteine desulfurase FEM46_09270 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FEM46_09280 ENOG4108YZ4 nudix hydrolase FEM46_09285 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FEM46_09295 ENOG4105DY9 regulatoR FEM46_09310 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FEM46_09325 ENOG41067XK integral membrane protein FEM46_09330 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FEM46_09345 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FEM46_09350 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FEM46_09355 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FEM46_09360 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FEM46_09365 ENOG4105CJN penicillin-binding protein FEM46_09375 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FEM46_09380 ENOG4108V6E Cell division protein mraZ FEM46_09400 ENOG4105CNU cell division protein FtsK FEM46_09405 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FEM46_09415 ENOG4105CWM branched-chain amino acid transport system II carrier protein FEM46_09430 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FEM46_09445 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FEM46_09450 ENOG4106N3A copper homeostasis protein cutc FEM46_09455 ENOG4105EMS pseudouridine synthase FEM46_09460 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FEM46_09475 ENOG4105DPN Oligoendopeptidase f FEM46_09485 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis FEM46_09490 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FEM46_09495 ENOG4108RQ5 Beta-lactamase domain-containing protein FEM46_09645 ENOG4105DQR SNARE associated Golgi FEM46_09655 ENOG4105D4U had-superfamily hydrolase, subfamily iia FEM46_09660 ENOG4105MMD transcriptional regulator FEM46_09665 ENOG4107R8B 5'-nucleotidase FEM46_09680 ENOG4105C85 amino acid FEM46_09685 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FEM46_09730 ENOG4105CDY transcriptional regulatory protein FEM46_09745 ENOG4105ETE Transcriptional regulator (LacI family FEM46_09750 ENOG4105DC7 peptidase M24 FEM46_09770 ENOG4105D8X mechanosensitive ion channel FEM46_09775 ENOG4105CH2 amidohydrolase FEM46_09780 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FEM46_09795 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FEM46_09800 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FEM46_09810 ENOG4105K63 Thioredoxin FEM46_09815 ENOG4105C98 muts2 protein FEM46_09825 ENOG4105VPH UPF0473 protein FEM46_09830 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FEM46_09835 ENOG4105VBH UPF0297 protein FEM46_09840 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FEM46_09845 ENOG4105C1J atp-dependent rna helicase FEM46_09850 ENOG4105SFS phosphoesterase RecJ domain protein FEM46_09855 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FEM46_09860 ENOG4105VIE preprotein translocase, subunit YajC FEM46_09865 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FEM46_09870 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FEM46_09875 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FEM46_09880 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FEM46_09910 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FEM46_09915 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FEM46_09920 ENOG4105D48 metallophosphoesterase FEM46_09925 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) FEM46_09930 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FEM46_09935 ENOG4105CEV competence damage-inducible protein FEM46_09940 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FEM46_09960 ENOG4105CFH Aspartokinase FEM46_09970 ENOG4108HW3 (ABC) transporter FEM46_09975 ENOG4105CDA abc transporter atp-binding protein FEM46_09980 ENOG4105E5Q amino acid AbC transporter FEM46_09985 ENOG4107QMS site-determining protein FEM46_10000 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FEM46_10005 ENOG4105DFF Rod shape-determining protein mreb FEM46_10010 ENOG4105W5Q DNA repair protein (RadC FEM46_10015 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FEM46_10020 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FEM46_10030 ENOG4105D9M gamma-glutamylcysteine synthetase FEM46_10035 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FEM46_10040 ENOG4105C3J Cysteine desulfurase FEM46_10050 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) FEM46_10060 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FEM46_10065 ENOG4108WQ8 UPF0637 protein FEM46_10085 ENOG4105CG3 alpha amylase, catalytic region FEM46_10095 ENOG4105F3R pts system mannose fructose sorbose family iid FEM46_10100 ENOG4105ETZ PTS System FEM46_10105 ENOG4108IQ3 PTS system FEM46_10110 ENOG4105ETE Transcriptional regulator (LacI family FEM46_10115 ENOG4105D9M gamma-glutamylcysteine synthetase FEM46_10120 ENOG4105D1H recombination factor protein RarA FEM46_10135 ENOG4107YZX Universal stress protein FEM46_10155 ENOG4105CPF Cell wall formation (By similarity) FEM46_10175 ENOG4105D01 (LipO)protein FEM46_10180 ENOG4108UMI ABC transporter, permease FEM46_10185 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FEM46_10190 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FEM46_10205 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FEM46_10210 ENOG4105DFF Rod shape-determining protein mreb FEM46_10220 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FEM46_10225 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FEM46_10230 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FEM46_10235 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FEM46_10240 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FEM46_10245 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FEM46_10250 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FEM46_10255 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FEM46_10260 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FEM46_10275 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FEM46_10280 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FEM46_10285 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FEM46_10290 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FEM46_10295 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FEM46_10300 ENOG4107104 thymidine kinase FEM46_10305 ENOG4105DMS mur ligase FEM46_10310 ENOG4105F1K Glutamine amidotransferase FEM46_10315 ENOG4105DG6 mannose-6-phosphate isomerase FEM46_10320 ENOG4107S1E Beta-lactamase FEM46_10330 ENOG4105CM2 brancheD-chain amino acid aminotransferase FEM46_10345 ENOG4105BZ1 (ABC) transporter FEM46_10360 ENOG4107BJW polysaccharide deacetylase FEM46_10490 ENOG4105X36 (ribosomal) protein FEM46_10645 ENOG4108IMY Transcriptional regulator FEM46_10675 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FEM46_10685 ENOG41067V3 Antibiotic biosynthesis monooxygenase FEM46_10705 ENOG4108FPN Integrase FEM46_10745 ENOG4105T6C Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps FEM46_10790 ENOG4105BZ1 (ABC) transporter FEM46_10800 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FEM46_10810 ENOG4107QYV phosphohexose isomerase FEM46_10815 ENOG4105CSC Glucose uptake protein FEM46_10820 ENOG4105DR4 Methyltransferase FEM46_10825 ENOG4105BZU Histidine kinase FEM46_10830 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FEM46_10835 ENOG4105CAG UPF0210 protein FEM46_10840 ENOG4105VUC UPF0237 protein FEM46_10845 ENOG4108UZ3 Transporter FEM46_10865 ENOG41079KZ Major Facilitator Superfamily FEM46_10885 ENOG4107SN7 NLP P60 protein FEM46_10890 ENOG4105EW9 transcriptional regulator AsnC family FEM46_10905 ENOG4106TD9 Diguanylate cyclase FEM46_10910 ENOG4105C5H ABC transporter FEM46_10925 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase FEM46_10935 ENOG4105CI1 PTS System FEM46_10940 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FEM46_10945 ENOG4105EPR degv family FEM46_10950 ENOG4105D6E homoserine dehydrogenase FEM46_10960 ENOG4105CVG Homoserine O-transsuccinylase FEM46_10975 ENOG4105C7J ABC transporter, permease FEM46_10985 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FEM46_10990 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FEM46_10995 ENOG4107TS3 membrane protein, TerC FEM46_11000 ENOG4108UW5 maltose o-acetyltransferase FEM46_11005 ENOG4105CIH Imidazole acetol-phosphate transaminase FEM46_11010 ENOG41083RF phosphoribosyl-ATP pyrophosphatase FEM46_11015 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FEM46_11020 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FEM46_11025 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FEM46_11030 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FEM46_11035 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FEM46_11040 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FEM46_11045 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FEM46_11050 ENOG4107Z2D Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) FEM46_11055 ENOG4108W76 histidinol phosphate phosphatase hisj family FEM46_11080 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FEM46_11115 ENOG4105E0M Sulfatase FEM46_11120 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FEM46_11130 ENOG4105CAY ferredoxin--nadp reductase FEM46_11140 ENOG4108M1Z surface protein FEM46_11145 ENOG4105CSR polyphosphate kinase 2 FEM46_11150 ENOG4108TVJ Nitroreductase FEM46_11160 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FEM46_11165 ENOG4105CSC Glucose uptake protein FEM46_11170 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) FEM46_11180 ENOG4105E98 transcriptional regulator DeoR family FEM46_11185 ENOG4105C6N Formate acetyltransferase FEM46_11190 ENOG4105DKT Transcriptional regulator FEM46_11210 ENOG4106KNT transcriptional regulator FEM46_11215 ENOG4105EE0 oxidoreductase FEM46_11220 ENOG4105D9R oxidoreductase FEM46_11225 ENOG4107SUZ Sodium/hydrogen exchanger family FEM46_11230 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FEM46_11245 ENOG4105CZV ABC transporter FEM46_11250 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FEM46_11295 ENOG4105C7K acetolactate synthase FEM46_11305 ENOG4108MXZ Esterase FEM46_11315 ENOG4105C28 cystathionine FEM46_11330 ENOG41081I9 integral membrane protein FEM46_11345 ENOG4105DF9 Lipoate-protein, ligase FEM46_11350 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FEM46_11360 ENOG4105F3R pts system mannose fructose sorbose family iid FEM46_11365 ENOG4105ETZ PTS System FEM46_11370 ENOG4108UZY PTS System FEM46_11375 ENOG4105FDP GntR family transcriptional regulator FEM46_11380 ENOG4107YZX Universal stress protein FEM46_11385 ENOG4108YBP pseudouridine synthase FEM46_11400 ENOG4105CG5 Glycosyl transferase (Group 1 FEM46_11405 ENOG4107QRI Phosphoketolase FEM46_11410 ENOG4107UWA esterase FEM46_11415 ENOG4108TZY GntR Family Transcriptional Regulator FEM46_11420 ENOG4108Z66 YbaK ebsC protein FEM46_11460 ENOG4105C37 (CBS) domain FEM46_11465 ENOG4105MTF NrdI protein FEM46_11470 ENOG4107SUZ Sodium/hydrogen exchanger family FEM46_11475 ENOG410605W Major Facilitator FEM46_11480 ENOG4107TXC Transcriptional regulator FEM46_11485 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FEM46_11495 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FEM46_11505 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FEM46_11510 ENOG4105CHM Aminotransferase FEM46_11530 ENOG4107ZGM malolactic fermentation system FEM46_11545 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FEM46_11550 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FEM46_11560 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FEM46_11565 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FEM46_11570 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) FEM46_11575 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FEM46_11580 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FEM46_11585 ENOG4105CD3 dihydroorotase FEM46_11590 ENOG4105CXT aspartate transcarbamylase FEM46_11595 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FEM46_11600 ENOG4105G9B Transcriptional regulator FEM46_11610 ENOG4105C7N Xanthine uracil vitamin C permease FEM46_11630 ENOG4105CND Glycosyl transferase, family 2 FEM46_11640 ENOG4105C12 Phosphoribosylglycinamide synthetase FEM46_11645 ENOG4105DC1 bifunctional purine biosynthesis protein purh FEM46_11650 ENOG4108V3E phosphoribosylglycinamide formyltransferase FEM46_11655 ENOG4105CXB phosphoribosylaminoimidazole synthetase FEM46_11660 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FEM46_11665 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FEM46_11670 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FEM46_11675 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FEM46_11680 ENOG4105C8V SAICAR synthetase FEM46_11685 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FEM46_11690 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FEM46_11695 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FEM46_11700 ENOG4107EFR Flavocytochrome c FEM46_11705 ENOG4105DF9 Lipoate-protein, ligase FEM46_11710 ENOG4105M2Z protein tyrosine serine phosphatase FEM46_11725 ENOG4105HDK L-asparaginase FEM46_11730 ENOG4105C19 ABC transporter FEM46_11745 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FEM46_11750 ENOG4105DVE abc transporter atp-binding protein FEM46_11760 ENOG4107YZX Universal stress protein FEM46_11770 ENOG4105WH5 Teichoic acid glycosylation protein FEM46_11790 ENOG4105C87 Aminotransferase class I and II FEM46_11810 ENOG4108IUK alpha amylase, catalytic FEM46_11815 ENOG4105D98 threonine synthase FEM46_11820 ENOG410667J hydrolase FEM46_11830 ENOG4108UW5 maltose o-acetyltransferase FEM46_11835 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FEM46_11870 ENOG4105DAP Nicotinate phosphoribosyltransferase FEM46_11875 ENOG4105MKU Transcriptional regulator FEM46_11890 ENOG4105BZC d-serine deaminase FEM46_11895 ENOG4105CS2 ec 3.2.1.21 FEM46_11900 ENOG4105CS2 ec 3.2.1.21 FEM46_11905 ENOG4105VCP PTS System FEM46_11910 ENOG4105VZJ PTS System FEM46_11915 ENOG4107414 GntR family transcriptional regulator FEM46_11920 ENOG4105K64 Glycosyl transferase, family 2 FEM46_11940 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FEM46_11945 ENOG4108UZ3 Transporter FEM46_11965 ENOG4105NQC Flavodoxin FEM46_11985 ENOG4105FF2 Type I DHQase FEM46_11990 ENOG4105E5D amino acid FEM46_12035 ENOG4105PUK Membrane FEM46_12040 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FEM46_12075 ENOG4108UQV Membrane FEM46_12080 ENOG4108Z5V transcriptional regulator, merr family FEM46_12095 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FEM46_12100 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FEM46_12135 ENOG4108IJ0 Aspartate ammonia-lyase FEM46_12145 ENOG4105EQ0 Major Facilitator superfamily FEM46_12170 ENOG4105HMI Membrane FEM46_12175 ENOG4105DUM transcriptional regulator, lysR family FEM46_12180 ENOG4107XU6 Glycosyl transferase (Group 1 FEM46_12185 ENOG4105E2K Glycosyl transferase (Group 1 FEM46_12205 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FEM46_12215 ENOG4108IUX (ABC) transporter FEM46_12225 ENOG4107GJV short-chain dehydrogenase reductase FEM46_12240 ENOG4105VUF Transcriptional regulator FEM46_12260 ENOG4105CSM endonuclease III FEM46_12270 ENOG4105C3F Signal peptidase i FEM46_12280 ENOG4105C3F Signal peptidase i FEM46_12290 ENOG4108W0I acetyltransferase FEM46_12320 ENOG4108KB2 LysR family Transcriptional regulator FEM46_12330 ENOG4105CPQ Dehydrogenase FEM46_12335 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FEM46_12345 ENOG4107YZX Universal stress protein FEM46_12350 ENOG4108UW5 maltose o-acetyltransferase FEM46_12370 ENOG4105C87 Aminotransferase class I and II FEM46_12380 ENOG4105CPC Aldo Keto reductase FEM46_12385 ENOG4105BZ1 (ABC) transporter FEM46_12390 ENOG4105BZ1 (ABC) transporter FEM46_12395 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEM46_12410 ENOG4105ECB domain protein FEM46_12410 ENOG4105ECB domain protein FEM46_12420 ENOG4107YCR Transcriptional regulator, ARSR family FEM46_12425 ENOG4105ZT7 DNA-entry nuclease FEM46_12450 ENOG4105C5H ABC transporter FEM46_12455 ENOG4108HCJ Hydrolase FEM46_12465 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FEM46_12480 ENOG4105DEU major facilitator superfamily FEM46_12515 ENOG4105BZU Histidine kinase FEM46_12520 ENOG4107XTP (EAL) domain protein FEM46_12525 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FEM46_12530 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FEM46_12540 ENOG4107YDN peptide deformylase FEM46_12570 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family FEM46_12580 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FEM46_12640 ENOG4108UZ3 Transporter FEM46_12665 ENOG41066F8 ROK family FEM46_12675 ENOG4105BZ1 (ABC) transporter FEM46_12685 ENOG4108TVJ Nitroreductase FEM46_12690 ENOG4105CI1 PTS System FEM46_12695 ENOG4105E2Y ABC, transporter FEM46_12700 ENOG4105C7J ABC transporter, permease FEM46_12735 ENOG4108IV0 ABC, transporter FEM46_12740 ENOG4105C0Z ABC transporter FEM46_12745 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FEM46_12750 ENOG4105C32 Amino acid ABC transporter (Permease) FEM46_12755 ENOG4105CP9 extracellular ligand-binding receptor FEM46_12770 ENOG4105WH5 Teichoic acid glycosylation protein FEM46_12780 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FEM46_12800 ENOG4107YCR Transcriptional regulator, ARSR family FEM46_12815 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FEM46_12850 ENOG4105VZJ PTS System FEM46_12855 ENOG4105CK1 PTS System FEM46_12860 ENOG4105CS2 ec 3.2.1.21 FEM46_12870 ENOG4105VUF Transcriptional regulator FEM46_12875 ENOG4106770 Is able to cleave peptidoglycan (By similarity) FEM46_12895 ENOG4105DSE periplasmic solute binding protein FEM46_12920 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FEM46_12935 ENOG4107GJV short-chain dehydrogenase reductase FEM46_12965 ENOG4105CHR reductase FEM46_12980 ENOG4105BZ1 (ABC) transporter FEM46_12985 ENOG4105BZ1 (ABC) transporter FEM46_13000 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FEM46_13015 ENOG4107SC7 Inner membrane transporter yjeM FEM46_13040 ENOG4105C59 p-type ATPase FEM46_13100 ENOG4105CPQ Dehydrogenase FEM46_13140 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 FEM46_13145 ENOG4105KVH Transcriptional regulator FEM46_13150 ENOG4105F27 Major Facilitator FEM46_13160 ENOG4105CAQ asparagine synthetase FEM46_13165 ENOG4108WCX response regulator FEM46_13180 ENOG4107Z3H Transcriptional regulator, TetR family FEM46_13190 ENOG4105C26 Dehydrogenase FEM46_13205 ENOG4105KVH Transcriptional regulator FEM46_13230 ENOG4107RGM aldo keto reductase FEM46_13245 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEM46_13260 ENOG4105E0A ABC, transporter FEM46_13265 ENOG4105DQ5 transport system permease protein FEM46_13270 ENOG4105EHG Permease protein FEM46_13285 ENOG4105EMU Dehydrogenase FEM46_13290 ENOG4108UW5 maltose o-acetyltransferase FEM46_13295 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FEM46_13335 ENOG4106KNP GTP-binding protein LepA C-terminus FEM46_13350 ENOG4105E09 nadh pyrophosphatase FEM46_13370 ENOG4105HUF DNA protection during starvation protein FEM46_13380 ENOG4105CS2 ec 3.2.1.21 FEM46_13385 ENOG4105CK1 PTS System FEM46_13410 ENOG4105VUF Transcriptional regulator FEM46_13430 ENOG4108V4B ThiJ pfpI FEM46_13455 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FEM46_13465 ENOG4105DG4 malate L-lactate dehydrogenase FEM46_13470 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FEM46_13490 ENOG4105S7A ErfK ybiS ycfS ynhG family protein FEM46_13505 ENOG4105HMD FEM46_13510 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEM46_13540 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FEM46_13545 ENOG4106F5Q Membrane FEM46_13560 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FEM46_13570 ENOG4105D9P serine threonine protein kinase FEM46_13610 ENOG4107TCE N-acetyltransferase FEM46_13640 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FEM46_13650 ENOG4105C3G gtp-binding protein FEM46_13655 ENOG4105VDK protein, conserved in bacteria FEM46_13660 ENOG4105FA0 parb-like partition protein FEM46_13665 ENOG4107QJE Chromosome Partitioning Protein FEM46_13675 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FEM46_13695 ENOG4105W8I Transcriptional regulator FEM46_13700 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FEM46_13705 ENOG4105EAB amino acid AbC transporter FEM46_13710 ENOG4105DRP amino acid AbC transporter FEM46_13715 ENOG4105CDA abc transporter atp-binding protein FEM46_13720 ENOG4105EAB amino acid AbC transporter FEM46_13745 ENOG4105C5Y PTS System FEM46_13750 ENOG4105CG3 alpha amylase, catalytic region FEM46_13770 ENOG4105C4B ABC transporter, permease FEM46_13775 ENOG41083J0 (ABC) transporter FEM46_13780 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FEM46_13795 ENOG4105C5Y PTS System FEM46_13810 ENOG4107RSM transcriptional regulator FEM46_13820 ENOG410667J hydrolase FEM46_13830 ENOG4105C8I hydrolase, family 38 FEM46_13835 ENOG4105DM4 PTS System FEM46_13840 ENOG4108YRF PTS System FEM46_13845 ENOG4105DM4 PTS System FEM46_13850 ENOG4105EMD TRANSCRIPTIONal FEM46_13865 ENOG4105C5Y PTS System FEM46_13895 ENOG4105G5W regulator Fur family FEM46_13920 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) FEM46_13930 ENOG4108RCR degv family FEM46_14170 ENOG4108IMY Transcriptional regulator FEM46_14210 ENOG4105EWK phytoene FEM46_14215 ENOG4105FE1 phytoene synthase FEM46_14225 ENOG4105BZW Glycerate kinase FEM46_14230 ENOG4105DC8 reductase FEM46_14240 ENOG4105C83 adenylosuccinate lyase FEM46_14245 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FEM46_14250 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FEM46_14255 ENOG4105M2Z protein tyrosine serine phosphatase FEM46_14260 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FEM46_14270 ENOG4105CUB amino acid FEM46_14275 ENOG4105DFH Transport of potassium into the cell (By similarity) FEM46_14285 ENOG4106F5Q Membrane FEM46_14305 ENOG4108UT2 hemolysin iii FEM46_14315 ENOG4105PGM cation diffusion facilitator family transporter FEM46_14335 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FEM46_14345 ENOG4105EUJ GTP cyclohydrolase i FEM46_14365 ENOG4105DSE periplasmic solute binding protein FEM46_14370 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEM46_14400 ENOG4107S1E Beta-lactamase FEM46_14405 ENOG4105C6N Formate acetyltransferase FEM46_14410 ENOG4105F1A Pyruvate formate-lyase FEM46_14420 ENOG4105VG1 fes assembly suf system protein FEM46_14425 ENOG4107RGM aldo keto reductase FEM46_14455 ENOG4105C94 Transporter FEM46_14460 ENOG4105C59 p-type ATPase FEM46_14480 ENOG4105CPN adenine deaminase FEM46_14485 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FEM46_14495 ENOG4105DFD Na H antiporter FEM46_14500 ENOG4105C85 amino acid FEM46_14510 ENOG4108W5N phosphatidylglycerophosphatase a FEM46_14530 ENOG4105K78 MarR family Transcriptional regulator FEM46_14540 ENOG4105CEN a g-specific adenine glycosylase FEM46_14555 ENOG4105VN1 Heat shock protein FEM46_14575 ENOG4108UZ3 Transporter FEM46_14590 ENOG4107QHE Choloylglycine hydrolase FEM46_14600 ENOG4105NA0 Transcriptional regulator FEM46_14615 ENOG4105C0R drug resistance transporter emrb qaca subfamily FEM46_14675 ENOG4105CGH 5'-nucleotidase FEM46_14705 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FEM46_14710 ENOG4108UVJ appr-1-p processing domain protein FEM46_14745 ENOG41075H3 AraC family transcriptional regulator FEM46_14770 ENOG4105CVK Glutamate decarboxylase FEM46_14810 ENOG4105EJ2 Transcriptional regulator FEM46_14820 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FEM46_14840 ENOG4105C59 p-type ATPase FEM46_14845 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FEM46_14875 ENOG4105IJJ transcriptional regulator, crp fnr family FEM46_14880 ENOG4105C9K Endothelin-converting enzyme 1 FEM46_14905 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FEM46_14955 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FEM46_14970 ENOG4105CWM branched-chain amino acid transport system II carrier protein FEM46_14975 ENOG4107RBJ symporter FEM46_14995 ENOG4107UWP Major facilitator superfamily MFS_1 FEM46_15015 ENOG4105MZU cell filamentation protein FEM46_15020 ENOG4105W08 virulence gene repressor rsal FEM46_15025 ENOG4105CQ4 Transcriptional regulator FEM46_15030 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase FEM46_15035 ENOG4105CMR udp-glucose 4-epimerase FEM46_15040 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FEM46_15055 ENOG4105DME alpha-galactosidase FEM46_15060 ENOG4107RBJ symporter FEM46_15065 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FEM46_15070 ENOG4105CQ4 Transcriptional regulator FEM46_15075 ENOG4105CPC Aldo Keto reductase FEM46_15095 ENOG4105FF2 Type I DHQase FEM46_15100 ENOG4105E2X shikimate dehydrogenase FEM46_15105 ENOG4105C5Q Transcriptional regulator FEM46_15110 ENOG4105EMV Major Facilitator FEM46_15135 ENOG4105DUM transcriptional regulator, lysR family FEM46_15140 ENOG4105EMV Major Facilitator FEM46_15150 ENOG41088PD hydrolase FEM46_15155 ENOG4105FDP GntR family transcriptional regulator FEM46_15160 ENOG4105CK1 PTS System FEM46_15165 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FEM46_15170 ENOG4105RD7 BadF BadG BcrA BcrD FEM46_15180 ENOG4105CS2 ec 3.2.1.21 FEM46_15190 ENOG4105CID antiterminator FEM46_15195 ENOG4105CS2 ec 3.2.1.21 FEM46_15200 ENOG4105CS2 ec 3.2.1.21 FEM46_15205 ENOG4105C5Y PTS System FEM46_15220 ENOG4105ETE Transcriptional regulator (LacI family FEM46_15240 ENOG4107QHE Choloylglycine hydrolase FEM46_15255 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FEM46_15260 ENOG4105UP7 3-epimerase FEM46_15265 ENOG4105DM4 PTS System FEM46_15270 ENOG4108YRF PTS System FEM46_15275 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FEM46_15285 ENOG4105ETD TRANSCRIPTIONal FEM46_15295 ENOG4105DT3 PTS system, galactitol-specific IIc component FEM46_15300 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) FEM46_15310 ENOG4105E98 transcriptional regulator DeoR family FEM46_15315 ENOG4107QRI Phosphoketolase FEM46_15325 ENOG4108UW5 maltose o-acetyltransferase FEM46_15330 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FEM46_15345 ENOG4107QNK )-transporter FEM46_15350 ENOG4105CMD Transcriptional regulator, GntR family FEM46_15355 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) FEM46_15385 ENOG4107BMA Transglycosylase associated protein FEM46_15390 ENOG4105CH6 catalase FEM46_15395 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FEM46_15400 ENOG4108WCX response regulator FEM46_15415 ENOG410695V Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP (By similarity) FEM46_15435 ENOG4105C7K acetolactate synthase FEM46_15440 ENOG4108Z40 Transcriptional regulator FEM46_15445 ENOG4105C7K acetolactate synthase FEM46_15460 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) FEM46_15465 ENOG4105DKG l-rhamnose isomerase FEM46_15470 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) FEM46_15475 ENOG4105DET Rhamnulokinase FEM46_15485 ENOG41075H3 AraC family transcriptional regulator FEM46_15490 ENOG4105E98 transcriptional regulator DeoR family FEM46_15505 ENOG4105F9F transposase FEM46_15530 ENOG4105EV1 Ribose uptake protein RbsU FEM46_15535 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FEM46_15545 ENOG4105ETE Transcriptional regulator (LacI family FEM46_15550 ENOG4108EKI Dehydrogenase FEM46_15560 ENOG4105U3E Transcriptional regulator FEM46_15565 ENOG4105PY6 Phenolic acid decarboxylase FEM46_15595 ENOG4105C3F Signal peptidase i FEM46_15620 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FEM46_15625 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FEM46_15640 ENOG4107QSI ABC, transporter FEM46_15645 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FEM46_15650 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FEM46_15655 ENOG4105VG0 50S ribosomal protein l34 FEM46_15680 ENOG4107QJE Chromosome Partitioning Protein FEM46_15695 ENOG4108C33 Resolvase FEM46_15705 ENOG4105F3R pts system mannose fructose sorbose family iid FEM46_15710 ENOG4105ETZ PTS System FEM46_15715 ENOG4108IQ3 PTS system FEM46_15720 ENOG4108XCU pts system FEM46_15725 ENOG4105CHR reductase FEM46_15735 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein FEM46_15850 ENOG4105C57 major facilitator superfamily FEM46_15865 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FEM46_15885 ENOG4105C85 amino acid FEM46_15890 ENOG41086FC 50S ribosomal protein l32 FEM46_15900 ENOG4105WDJ 50S ribosomal protein L33 FEM46_15905 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FEM46_15910 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FEM46_15925 ENOG4108JYZ YitT family FEM46_16080 ENOG4108KGH TRANSCRIPTIONal FEM46_16090 ENOG4107YJ4 chain length determinant protein FEM46_16095 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FEM46_16100 ENOG4105D3Q Sugar transferase FEM46_16105 ENOG4107XU6 Glycosyl transferase (Group 1 FEM46_16110 ENOG4108KMV Glycosyl transferase (Group 1 FEM46_16115 ENOG4108KMV Glycosyl transferase (Group 1 FEM46_16120 ENOG4105F9F transposase FEM46_16200 ENOG4105DQ6 Transposase FEM46_16205 ENOG4108KHS signal transduction Histidine kinase FEM46_16215 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) FEM46_16220 ENOG41067MG lrgb family FEM46_16235 ENOG4108C33 Resolvase FEM46_16255 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FEM46_16290 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FEM46_16300 ENOG4107QJE Chromosome Partitioning Protein FEM46_16360 ENOG4105C9U ATP-dependent DNA helicase RecQ FEM46_16390 ENOG4108V4B ThiJ pfpI FEM46_16420 ENOG4105F9F transposase