locus-tag	class	description
FEM46_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FEM46_00010	COG0592	DNA-directed DNA polymerase activity
FEM46_00015	COG2501	S4 domain
FEM46_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FEM46_00025	COG0187	DNA topoisomerase II activity
FEM46_00035	COG0360	Binds together with S18 to 16S ribosomal RNA
FEM46_00040	COG0629	single-stranded DNA binding
FEM46_00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FEM46_00055	COG0359	binds to the 23S rRNA
FEM46_00060	COG0305	Participates in initiation and elongation during chromosome replication
FEM46_00065	COG2814	Major facilitator Superfamily
FEM46_00070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FEM46_00075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FEM46_00080	COG4166	transmembrane transport
FEM46_00085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FEM46_00090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FEM46_00095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FEM46_00100	COG0297	glycogen (starch) synthase activity
FEM46_00105	COG0058	SHG alpha-glucan phosphorylase activity
FEM46_00110	COG0366	Alpha amylase catalytic
FEM46_00110	COG3103	Sh3 type 3 domain protein
FEM46_00120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEM46_00125	COG1554	hydrolase, family 65, central catalytic
FEM46_00135	COG1278	Cold shock
FEM46_00215	COG4695	Portal protein
FEM46_00250	COG0745	RESPONSE REGULATOR receiver
FEM46_00255	COG5002	protein histidine kinase activity
FEM46_00265	COG4853	Protein conserved in bacteria
FEM46_00270	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FEM46_00275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FEM46_00280	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FEM46_00290	COG1012	belongs to the aldehyde dehydrogenase family
FEM46_00295	COG3586	endonuclease activity
FEM46_00300	COG1573	uracil-dna glycosylase
FEM46_00320	COG0431	NADPH-dependent FMN reductase
FEM46_00320	COG3976	FMN-binding domain protein
FEM46_00320	COG1053	succinate dehydrogenase
FEM46_00325	COG0471	metal ion transport
FEM46_00340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FEM46_00345	COG1028	Short-chain dehydrogenase reductase Sdr
FEM46_00355	COG0778	Nitroreductase
FEM46_00360	COG2508	Transcriptional regulator
FEM46_00370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEM46_00375	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FEM46_00385	COG2365	Tyrosine phosphatase family
FEM46_00390	COG2368	4-hydroxyphenylacetate
FEM46_00410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FEM46_00445	COG0604	alcohol dehydrogenase
FEM46_00470	COG2267	carboxylic ester hydrolase activity
FEM46_00475	COG3022	response to hydroperoxide
FEM46_00485	COG4166	transmembrane transport
FEM46_00510	COG1122	ATPase activity
FEM46_00515	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FEM46_00520	COG0310	cobalt ion transport
FEM46_00525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FEM46_00530	COG3875	lactate racemase activity
FEM46_00535	COG1691	(AIR) carboxylase
FEM46_00540	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
FEM46_00545	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
FEM46_00550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FEM46_00555	COG1606	tRNA processing
FEM46_00565	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FEM46_00570	COG0351	phosphomethylpyrimidine kinase
FEM46_00575	COG0352	thiamine-phosphate diphosphorylase activity
FEM46_00585	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FEM46_00600	COG1113	amino acid transport
FEM46_00610	COG2267	carboxylic ester hydrolase activity
FEM46_00620	COG1983	PspC domain protein
FEM46_00660	COG2807	transmembrane transport
FEM46_00665	COG0656	L-ascorbic acid biosynthetic process
FEM46_00670	COG0667	Aldo Keto reductase
FEM46_00700	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FEM46_00705	COG1122	ATPase activity
FEM46_00710	COG4720	Psort location CytoplasmicMembrane, score
FEM46_00720	COG2188	Transcriptional regulator
FEM46_00745	COG1028	Short-chain dehydrogenase reductase Sdr
FEM46_00750	COG1131	(ABC) transporter
FEM46_00765	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FEM46_00770	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
FEM46_00775	COG1309	transcriptional regulator
FEM46_00780	COG2376	Dihydroxyacetone kinase
FEM46_00785	COG2376	Dihydroxyacetone kinase
FEM46_00790	COG1461	Dihydroxyacetone kinase
FEM46_00795	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FEM46_00800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FEM46_00805	COG1609	Transcriptional regulator
FEM46_00810	COG1609	Transcriptional regulator
FEM46_00820	COG2182	Extracellular solute-binding protein
FEM46_00825	COG1175	transmembrane transport
FEM46_00830	COG3833	ABC-type maltose transport systems, permease component
FEM46_00840	COG0366	Alpha amylase catalytic
FEM46_00845	COG3842	ATPase activity
FEM46_00930	COG4166	transmembrane transport
FEM46_00935	COG4166	transmembrane transport
FEM46_00945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FEM46_00950	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FEM46_00955	COG0406	alpha-ribazole phosphatase activity
FEM46_00960	COG0667	Aldo Keto reductase
FEM46_00990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FEM46_00995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FEM46_01010	COG4172	Belongs to the ABC transporter superfamily
FEM46_01020	COG0386	Belongs to the glutathione peroxidase family
FEM46_01030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FEM46_01045	COG0363	glucosamine-6-phosphate deaminase activity
FEM46_01055	COG2213	PTS system mannitol-specific
FEM46_01065	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEM46_01070	COG0246	Mannitol dehydrogenase
FEM46_01080	COG3118	belongs to the thioredoxin family
FEM46_01110	COG0431	NADPH-dependent FMN reductase
FEM46_01115	COG1045	serine acetyltransferase
FEM46_01120	COG0626	cystathionine gamma-synthase activity
FEM46_01125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FEM46_01130	COG0024	Methionine aminopeptidase
FEM46_01155	COG2188	Transcriptional regulator
FEM46_01160	COG0366	Alpha amylase catalytic
FEM46_01165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_01165	COG2190	(PTS) system
FEM46_01165	COG1263	PTS System
FEM46_01170	COG1263	PTS System
FEM46_01170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_01170	COG2190	(PTS) system
FEM46_01180	COG0163	prenyltransferase activity
FEM46_01190	COG1959	2 iron, 2 sulfur cluster binding
FEM46_01195	COG1309	transcriptional regulator
FEM46_01200	COG1914	H( )-stimulated, divalent metal cation uptake system
FEM46_01230	COG5002	protein histidine kinase activity
FEM46_01235	COG0745	RESPONSE REGULATOR receiver
FEM46_01245	COG1737	Transcriptional regulator
FEM46_01250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEM46_01265	COG1316	TRANSCRIPTIONal
FEM46_01270	COG0277	FAD linked oxidase domain protein
FEM46_01280	COG2357	RelA SpoT domain protein
FEM46_01290	COG1033	growth of symbiont in host cell
FEM46_01290	COG2409	Drug exporters of the RND superfamily
FEM46_01290	COG1033	growth of symbiont in host cell
FEM46_01290	COG2409	Drug exporters of the RND superfamily
FEM46_01295	COG2818	Glycosylase
FEM46_01305	COG0577	efflux transmembrane transporter activity
FEM46_01310	COG1136	(ABC) transporter
FEM46_01325	COG0741	lytic transglycosylase activity
FEM46_01330	COG3942	CHAP domain
FEM46_01330	COG1388	LysM domain
FEM46_01360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FEM46_01370	COG1846	Transcriptional regulator
FEM46_01375	COG1252	NADH dehydrogenase
FEM46_01415	COG3842	ATPase activity
FEM46_01445	COG1725	Transcriptional regulator
FEM46_01450	COG1131	(ABC) transporter
FEM46_01460	COG1454	alcohol dehydrogenase
FEM46_01460	COG1012	belongs to the aldehyde dehydrogenase family
FEM46_01495	COG1268	BioY protein
FEM46_01520	COG2011	ABC-type metal ion transport system permease component
FEM46_01525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FEM46_01530	COG0436	Aminotransferase
FEM46_01540	COG1682	transport, permease protein
FEM46_01545	COG1134	teichoic acid transport
FEM46_01565	COG0004	ammonium transporteR
FEM46_01585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FEM46_01595	COG3759	membrane
FEM46_01600	COG1881	PFAM PEBP family protein
FEM46_01630	COG0300	oxidoreductase activity
FEM46_01640	COG0328	RNA-DNA hybrid ribonuclease activity
FEM46_01650	COG1125	glycine betaine transport
FEM46_01660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FEM46_01670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FEM46_01760	COG0110	maltose O-acetyltransferase activity
FEM46_01770	COG0561	phosphatase activity
FEM46_01780	COG0561	phosphatase activity
FEM46_01785	COG1114	Component of the transport system for branched-chain amino acids
FEM46_01830	COG0463	Glycosyl transferase, family 2
FEM46_01855	COG3279	Response regulator of the LytR AlgR family
FEM46_01880	COG2274	protein secretion by the type I secretion system
FEM46_01920	COG3973	AAA domain
FEM46_01925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FEM46_01930	COG0180	Tryptophanyl-tRNA synthetase
FEM46_01935	COG2188	Transcriptional regulator
FEM46_01940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEM46_01955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEM46_01960	COG2723	6-phospho-beta-galactosidase activity
FEM46_01965	COG1940	carbohydrate kinase activity
FEM46_01975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FEM46_01990	COG0248	Ppx GppA phosphatase
FEM46_02005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FEM46_02010	COG1801	Protein of unknown function DUF72
FEM46_02020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FEM46_02020	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FEM46_02025	COG2814	Major facilitator Superfamily
FEM46_02030	COG0084	hydrolase, TatD family'
FEM46_02035	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FEM46_02040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FEM46_02045	COG4466	Protein conserved in bacteria
FEM46_02050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FEM46_02060	COG1073	alpha beta
FEM46_02065	COG1121	(ABC) transporter
FEM46_02070	COG1321	iron dependent repressor
FEM46_02070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FEM46_02100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FEM46_02105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FEM46_02115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FEM46_02135	COG1078	dGTPase activity
FEM46_02140	COG0095	Lipoate-protein ligase
FEM46_02150	COG3343	RNA polymerase activity
FEM46_02155	COG0504	CTP synthase activity
FEM46_02160	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FEM46_02165	COG0814	amino acid
FEM46_02175	COG1760	l-serine dehydratase
FEM46_02180	COG1760	l-serine dehydratase
FEM46_02195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FEM46_02200	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FEM46_02205	COG0254	rRNA binding
FEM46_02215	COG3764	Sortase (surface protein transpeptidase)
FEM46_02220	COG1704	LemA family
FEM46_02225	COG0501	Belongs to the peptidase M48B family
FEM46_02235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FEM46_02250	COG0736	holo-[acyl-carrier-protein] synthase activity
FEM46_02255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FEM46_02260	COG2337	Toxic component of a toxin-antitoxin (TA) module
FEM46_02265	COG3158	transport of potassium into the cell
FEM46_02285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FEM46_02290	COG0505	Belongs to the CarA family
FEM46_02295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FEM46_02300	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FEM46_02305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FEM46_02310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FEM46_02315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FEM46_02335	COG0039	L-malate dehydrogenase activity
FEM46_02340	COG0193	aminoacyl-tRNA hydrolase activity
FEM46_02345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FEM46_02350	COG2244	polysaccharide biosynthetic process
FEM46_02355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FEM46_02365	COG1098	S1 RNA binding domain
FEM46_02370	COG0037	tRNA processing
FEM46_02385	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FEM46_02395	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FEM46_02435	COG3104	oligopeptide transport
FEM46_02485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FEM46_02505	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FEM46_02510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FEM46_02525	COG2183	response to ionizing radiation
FEM46_02530	COG3091	SprT-like family
FEM46_02535	COG0460	homoserine dehydrogenase
FEM46_02540	COG0083	homoserine kinase activity
FEM46_02580	COG3715	PTS system
FEM46_02585	COG3716	PTS system mannose fructose sorbose family IID component
FEM46_02595	COG3933	PFAM sigma-54 factor interaction domain-containing protein
FEM46_02595	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FEM46_02600	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEM46_02600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_02605	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_02605	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEM46_02610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FEM46_02620	COG0439	Biotin carboxylase
FEM46_02630	COG0825	malonyl-CoA metabolic process
FEM46_02635	COG1316	TRANSCRIPTIONal
FEM46_02645	COG0697	spore germination
FEM46_02650	COG0588	phosphoglycerate mutase activity
FEM46_02665	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FEM46_02675	COG0756	dUTP diphosphatase activity
FEM46_02700	COG4956	integral membrane protein (PIN domain superfamily)
FEM46_02705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FEM46_02710	COG0215	cysteine-tRNA ligase activity
FEM46_02715	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FEM46_02720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FEM46_02735	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FEM46_02745	COG0250	Participates in transcription elongation, termination and antitermination
FEM46_02755	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FEM46_02760	COG0081	regulation of translation
FEM46_02765	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FEM46_02770	COG0222	ribosome binding
FEM46_02795	COG1611	Belongs to the LOG family
FEM46_02805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FEM46_02810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FEM46_02815	COG2813	Specifically methylates the guanine in position
FEM46_02830	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FEM46_02835	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FEM46_02840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FEM46_02850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FEM46_02855	COG3870	Protein conserved in bacteria
FEM46_02860	COG0470	DNA polymerase III
FEM46_02865	COG4467	Involved in initiation control of chromosome replication
FEM46_02880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FEM46_02885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FEM46_02890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEM46_02895	COG3639	organic phosphonate transmembrane transporter activity
FEM46_02905	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FEM46_02915	COG1214	PFAM Peptidase M22, glycoprotease
FEM46_02920	COG0456	acetyltransferase
FEM46_02925	COG0456	acetyltransferase
FEM46_02930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FEM46_02940	COG0488	(ABC) transporter
FEM46_02945	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FEM46_02955	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FEM46_02960	COG0459	protein refolding
FEM46_02965	COG0531	amino acid
FEM46_02970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FEM46_02975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FEM46_02980	COG1739	Uncharacterized protein family UPF0029
FEM46_02985	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FEM46_03000	COG0653	protein targeting
FEM46_03015	COG0745	RESPONSE REGULATOR receiver
FEM46_03020	COG5002	protein histidine kinase activity
FEM46_03025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FEM46_03030	COG0573	inorganic phosphate transmembrane transporter activity
FEM46_03035	COG0581	inorganic phosphate transmembrane transporter activity
FEM46_03040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FEM46_03045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FEM46_03050	COG0704	Plays a role in the regulation of phosphate uptake
FEM46_03055	COG1983	PspC domain protein
FEM46_03060	COG1950	PFAM Membrane protein of
FEM46_03065	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FEM46_03070	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FEM46_03075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FEM46_03090	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEM46_03110	COG1215	transferase activity, transferring glycosyl groups
FEM46_03125	COG0492	ferredoxin-NADP+ reductase activity
FEM46_03130	COG2323	membrane
FEM46_03140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FEM46_03150	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEM46_03160	COG2814	Major facilitator Superfamily
FEM46_03170	COG0556	nucleotide-excision repair
FEM46_03175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FEM46_03180	COG1854	S-ribosylhomocysteine lyase activity
FEM46_03185	COG0137	argininosuccinate synthase activity
FEM46_03190	COG0165	Argininosuccinate lyase
FEM46_03200	COG1660	Displays ATPase and GTPase activities
FEM46_03205	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FEM46_03210	COG1481	regulation of sporulation
FEM46_03220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FEM46_03225	COG0740	serine-type endopeptidase activity
FEM46_03235	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FEM46_03240	COG2390	Transcriptional regulator
FEM46_03250	COG0126	phosphoglycerate kinase activity
FEM46_03255	COG0149	triose-phosphate isomerase activity
FEM46_03260	COG0148	phosphopyruvate hydratase activity
FEM46_03275	COG0038	chloride channel
FEM46_03280	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FEM46_03290	COG0557	exoribonuclease II activity
FEM46_03295	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FEM46_03305	COG0765	amino acid transport
FEM46_03310	COG1126	abc transporter atp-binding protein
FEM46_03320	COG0561	phosphatase activity
FEM46_03325	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FEM46_03330	COG0280	phosphate acetyltransferase
FEM46_03335	COG0802	atpase or kinase
FEM46_03350	COG0708	Exodeoxyribonuclease III
FEM46_03360	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FEM46_03365	COG0025	NhaP-type Na H and K H
FEM46_03390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FEM46_03395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FEM46_03405	COG0561	phosphatase activity
FEM46_03415	COG2017	converts alpha-aldose to the beta-anomer
FEM46_03430	COG0778	Nitroreductase
FEM46_03450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FEM46_03465	COG1393	Belongs to the ArsC family
FEM46_03480	COG0477	Major facilitator Superfamily
FEM46_03485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FEM46_03485	COG0248	Ppx GppA phosphatase
FEM46_03490	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FEM46_03500	COG3475	LICD family
FEM46_03515	COG2252	PERMEase
FEM46_03520	COG0028	Belongs to the TPP enzyme family
FEM46_03525	COG0196	riboflavin kinase activity
FEM46_03530	COG0028	Belongs to the TPP enzyme family
FEM46_03535	COG2267	carboxylic ester hydrolase activity
FEM46_03545	COG2755	lipolytic protein G-D-S-L family
FEM46_03545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FEM46_03550	COG2936	dipeptidyl-peptidase activity
FEM46_03565	COG0531	amino acid
FEM46_03590	COG0194	GDP metabolic process
FEM46_03595	COG0735	belongs to the Fur family
FEM46_03610	COG0546	phosphoglycolate phosphatase activity
FEM46_03615	COG0436	Aminotransferase
FEM46_03620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FEM46_03640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FEM46_03645	COG0765	amino acid transport
FEM46_03650	COG0765	amino acid transport
FEM46_03655	COG1263	PTS System
FEM46_03655	COG2190	(PTS) system
FEM46_03655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_03665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_03665	COG1263	PTS System
FEM46_03670	COG3394	polysaccharide catabolic process
FEM46_03675	COG0531	amino acid
FEM46_03685	COG1846	Transcriptional regulator
FEM46_03715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FEM46_03725	COG2076	Multidrug Resistance protein
FEM46_03740	COG0588	phosphoglycerate mutase activity
FEM46_03745	COG0569	domain protein
FEM46_03745	COG0475	glutathione-regulated potassium exporter activity
FEM46_03750	COG0456	acetyltransferase
FEM46_03750	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FEM46_03755	COG0586	Pfam SNARE associated Golgi protein
FEM46_03760	COG3973	AAA domain
FEM46_03765	COG2070	2-Nitropropane dioxygenase
FEM46_03770	COG1072	(Pantothenic acid kinase))
FEM46_03775	COG0519	Catalyzes the synthesis of GMP from XMP
FEM46_03775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FEM46_03785	COG1396	sequence-specific DNA binding
FEM46_03795	COG1266	CAAX protease self-immunity
FEM46_03800	COG1733	regulation of RNA biosynthetic process
FEM46_03805	COG2814	Major facilitator Superfamily
FEM46_03845	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FEM46_03845	COG2755	lipolytic protein G-D-S-L family
FEM46_03850	COG2261	transglycosylase associated protein
FEM46_03865	COG1302	Protein conserved in bacteria
FEM46_03895	COG0308	aminopeptidase N
FEM46_03915	COG2801	Transposase and inactivated derivatives
FEM46_03945	COG0572	uridine kinase
FEM46_03960	COG0583	DNA-binding transcription factor activity
FEM46_03965	COG1053	succinate dehydrogenase
FEM46_03975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FEM46_03980	COG0017	Asparaginyl-tRNA synthetase
FEM46_03985	COG2502	aspartate--ammonia ligase
FEM46_03990	COG4690	dipeptidase activity
FEM46_04010	COG0514	ATP-dependent DNA helicase (RecQ)
FEM46_04015	COG0564	pseudouridine synthase activity
FEM46_04020	COG0640	Transcriptional regulator
FEM46_04070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FEM46_04075	COG0527	aspartate kinase activity
FEM46_04080	COG0367	asparagine synthase
FEM46_04130	COG2814	Major facilitator Superfamily
FEM46_04150	COG1278	Cold shock
FEM46_04155	COG2966	Psort location CytoplasmicMembrane, score
FEM46_04165	COG1316	TRANSCRIPTIONal
FEM46_04185	COG1959	2 iron, 2 sulfur cluster binding
FEM46_04190	COG0028	Belongs to the TPP enzyme family
FEM46_04195	COG0833	amino acid
FEM46_04205	COG1428	Deoxynucleoside kinase
FEM46_04210	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FEM46_04250	COG4463	regulation of RNA biosynthetic process
FEM46_04255	COG0542	response to heat
FEM46_04265	COG0085	RNA polymerase activity
FEM46_04270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FEM46_04275	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FEM46_04280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FEM46_04285	COG0049	tRNA binding
FEM46_04290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FEM46_04295	COG0051	transcription antitermination factor activity, RNA binding
FEM46_04300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FEM46_04305	COG0088	Forms part of the polypeptide exit tunnel
FEM46_04310	COG0089	rRNA binding
FEM46_04315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FEM46_04320	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FEM46_04325	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FEM46_04330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FEM46_04335	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FEM46_04340	COG0255	Belongs to the universal ribosomal protein uL29 family
FEM46_04345	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FEM46_04350	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FEM46_04355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FEM46_04360	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FEM46_04365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FEM46_04370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FEM46_04375	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FEM46_04380	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FEM46_04385	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FEM46_04390	COG1841	ribosomal large subunit assembly
FEM46_04395	COG0200	Binds to the 23S rRNA
FEM46_04405	COG0563	adenylate kinase activity
FEM46_04410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FEM46_04415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FEM46_04420	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FEM46_04425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FEM46_04430	COG0202	RNA polymerase activity
FEM46_04435	COG0203	ribosomal protein L17
FEM46_04460	COG4939	FMN-binding domain protein
FEM46_04470	COG1122	ATPase activity
FEM46_04475	COG1122	ATPase activity
FEM46_04485	COG0101	tRNA pseudouridine synthase activity
FEM46_04490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FEM46_04495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FEM46_04515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FEM46_04520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FEM46_04525	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FEM46_04530	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FEM46_04540	COG2151	metal-sulfur cluster biosynthetic enzyme
FEM46_04550	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FEM46_04555	COG4977	sequence-specific DNA binding
FEM46_04555	COG1917	Cupin 2, conserved barrel domain protein
FEM46_04560	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FEM46_04565	COG1121	(ABC) transporter
FEM46_04570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FEM46_04575	COG0803	Belongs to the bacterial solute-binding protein 9 family
FEM46_04585	COG0039	L-malate dehydrogenase activity
FEM46_04590	COG0471	metal ion transport
FEM46_04610	COG3052	prosthetic group binding
FEM46_04630	COG0114	fumarate hydratase activity
FEM46_04635	COG1053	succinate dehydrogenase
FEM46_04645	COG0583	DNA-binding transcription factor activity
FEM46_04650	COG0583	DNA-binding transcription factor activity
FEM46_04655	COG0281	malic enzyme
FEM46_04665	COG0531	amino acid
FEM46_04670	COG4684	Psort location CytoplasmicMembrane, score
FEM46_04685	COG1271	oxidase subunit
FEM46_04690	COG1294	oxidase, subunit
FEM46_04695	COG4988	ABC transporter
FEM46_04700	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FEM46_04715	COG0142	geranyltranstransferase activity
FEM46_04730	COG1705	Flagellar rod assembly protein muramidase FlgJ
FEM46_04735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FEM46_04740	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FEM46_04745	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FEM46_04755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FEM46_04760	COG4851	CamS sex pheromone cAM373 precursor
FEM46_04765	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FEM46_04770	COG0154	amidase activity
FEM46_04775	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FEM46_04780	COG1597	lipid kinase activity
FEM46_04785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FEM46_04800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEM46_04810	COG1737	Transcriptional regulator
FEM46_04825	COG1278	Cold shock
FEM46_04830	COG0673	inositol 2-dehydrogenase activity
FEM46_04835	COG0513	Belongs to the DEAD box helicase family
FEM46_04850	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEM46_04875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FEM46_04885	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FEM46_04895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FEM46_04900	COG0562	UDP-galactopyranose mutase
FEM46_04930	COG1216	Glycosyl transferase, family 2
FEM46_04930	COG1442	glycosyl transferase family 8
FEM46_04950	COG2244	polysaccharide biosynthetic process
FEM46_04955	COG3328	transposase activity
FEM46_04965	COG0562	UDP-galactopyranose mutase
FEM46_05000	COG1609	Transcriptional regulator
FEM46_05000	COG2207	Transcriptional regulator
FEM46_05025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FEM46_05060	COG2137	regulation of response to DNA damage stimulus
FEM46_05065	COG3557	Belongs to the UPF0374 family
FEM46_05085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FEM46_05095	COG0628	permease
FEM46_05100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FEM46_05105	COG2610	gluconate transmembrane transporter activity
FEM46_05110	COG1070	Carbohydrate kinase
FEM46_05115	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FEM46_05120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FEM46_05125	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FEM46_05160	COG4166	transmembrane transport
FEM46_05165	COG0601	transmembrane transport
FEM46_05170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FEM46_05175	COG0444	Belongs to the ABC transporter superfamily
FEM46_05180	COG4608	Belongs to the ABC transporter superfamily
FEM46_05190	COG0582	viral genome integration into host DNA
FEM46_05195	COG0542	response to heat
FEM46_05215	COG0438	transferase activity, transferring glycosyl groups
FEM46_05220	COG0438	transferase activity, transferring glycosyl groups
FEM46_05230	COG1686	Belongs to the peptidase S11 family
FEM46_05235	COG0436	Aminotransferase
FEM46_05240	COG4703	Protein of unknown function (DUF1797)
FEM46_05245	COG1368	sulfuric ester hydrolase activity
FEM46_05335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FEM46_05355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FEM46_05365	COG1914	H( )-stimulated, divalent metal cation uptake system
FEM46_05375	COG0833	amino acid
FEM46_05380	COG2040	homocysteine
FEM46_05385	COG0438	transferase activity, transferring glycosyl groups
FEM46_05395	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FEM46_05400	COG0477	Major facilitator Superfamily
FEM46_05415	COG0438	transferase activity, transferring glycosyl groups
FEM46_05430	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FEM46_05440	COG0495	leucyl-tRNA aminoacylation
FEM46_05445	COG2244	polysaccharide biosynthetic process
FEM46_05450	COG1187	pseudouridine synthase activity
FEM46_05455	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FEM46_05460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FEM46_05470	COG3842	ATPase activity
FEM46_05475	COG1175	transmembrane transport
FEM46_05480	COG0395	ABC-type sugar transport system, permease component
FEM46_05490	COG0584	glycerophosphoryl diester phosphodiesterase
FEM46_05495	COG1428	Deoxynucleoside kinase
FEM46_05500	COG1970	mechanosensitive ion channel activity
FEM46_05505	COG1511	domain protein
FEM46_05505	COG1511	domain protein
FEM46_05535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FEM46_05540	COG0789	Transcriptional regulator
FEM46_05550	COG0697	spore germination
FEM46_05555	COG0561	phosphatase activity
FEM46_05575	COG3279	Response regulator of the LytR AlgR family
FEM46_05595	COG1846	Transcriptional regulator
FEM46_05610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FEM46_05650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FEM46_05650	COG0646	methionine synthase
FEM46_05655	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FEM46_05665	COG2046	Belongs to the sulfate adenylyltransferase family
FEM46_05670	COG0529	Catalyzes the synthesis of activated sulfate
FEM46_05675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FEM46_05685	COG0471	metal ion transport
FEM46_05685	COG3273	potassium ion transport
FEM46_05690	COG0534	Mate efflux family protein
FEM46_05710	COG2153	protein acetylation
FEM46_05715	COG0018	arginyl-trna synthetase
FEM46_05725	COG1136	(ABC) transporter
FEM46_05725	COG0577	efflux transmembrane transporter activity
FEM46_05740	COG1376	ErfK ybiS ycfS ynhG family protein
FEM46_05745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FEM46_05750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEM46_05760	COG0436	Aminotransferase
FEM46_05765	COG1438	arginine binding
FEM46_05775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FEM46_05780	COG3679	Belongs to the UPF0342 family
FEM46_05785	COG0420	3'-5' exonuclease activity
FEM46_05790	COG4717	serine-type aminopeptidase activity
FEM46_05795	COG3481	metal-dependent phosphohydrolase, HD sub domain
FEM46_05810	COG0583	DNA-binding transcription factor activity
FEM46_05825	COG3976	FMN-binding domain protein
FEM46_05825	COG1053	succinate dehydrogenase
FEM46_05825	COG0431	NADPH-dependent FMN reductase
FEM46_05845	COG3850	Histidine kinase
FEM46_05845	COG5002	protein histidine kinase activity
FEM46_05850	COG0745	RESPONSE REGULATOR receiver
FEM46_05860	COG0463	Glycosyl transferase, family 2
FEM46_05865	COG0586	Pfam SNARE associated Golgi protein
FEM46_05870	COG0463	Glycosyl transferase, family 2
FEM46_05890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FEM46_05890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FEM46_05895	COG0307	riboflavin synthase, alpha
FEM46_05900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FEM46_05900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FEM46_05905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FEM46_05920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FEM46_05930	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEM46_05960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FEM46_05970	COG0537	adenosine 5'-monophosphoramidase activity
FEM46_05975	COG1131	(ABC) transporter
FEM46_05980	COG4473	ABC transporter
FEM46_05985	COG0510	thiamine kinase activity
FEM46_05990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FEM46_06025	COG1396	sequence-specific DNA binding
FEM46_06035	COG3646	Phage regulatory protein
FEM46_06240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FEM46_06245	COG1674	ftsk spoiiie
FEM46_06250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FEM46_06275	COG0719	Fe-S assembly protein
FEM46_06280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FEM46_06290	COG0719	Fe-S assembly protein
FEM46_06300	COG1120	ATPase activity
FEM46_06310	COG0716	FMN binding
FEM46_06325	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FEM46_06330	COG2223	nitrite transmembrane transporter activity
FEM46_06335	COG2151	metal-sulfur cluster biosynthetic enzyme
FEM46_06360	COG2197	response regulator
FEM46_06385	COG0315	cyclic pyranopterin monophosphate synthase activity
FEM46_06390	COG1763	Mo-molybdopterin cofactor biosynthetic process
FEM46_06395	COG0303	'Molybdopterin
FEM46_06405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FEM46_06410	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FEM46_06415	COG1140	nitrate reductase beta subunit
FEM46_06425	COG2181	nitrate reductase activity
FEM46_06465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FEM46_06465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FEM46_06470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FEM46_06475	COG0237	dephospho-CoA kinase activity
FEM46_06480	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FEM46_06490	COG1484	DNA-dependent DNA replication
FEM46_06495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FEM46_06500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FEM46_06505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FEM46_06510	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FEM46_06520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FEM46_06525	COG0604	alcohol dehydrogenase
FEM46_06530	COG1733	regulation of RNA biosynthetic process
FEM46_06540	COG1215	transferase activity, transferring glycosyl groups
FEM46_06555	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FEM46_06560	COG1534	Rna-binding protein
FEM46_06565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FEM46_06570	COG1713	HD superfamily hydrolase involved in NAD metabolism
FEM46_06575	COG0799	negative regulation of ribosome biogenesis
FEM46_06580	COG2226	methyltransferase
FEM46_06585	COG1323	Belongs to the UPF0348 family
FEM46_06595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FEM46_06610	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FEM46_06615	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FEM46_06620	COG0745	RESPONSE REGULATOR receiver
FEM46_06625	COG5002	protein histidine kinase activity
FEM46_06635	COG0419	ATPase involved in DNA repair
FEM46_06650	COG0706	membrane insertase activity
FEM46_06655	COG1254	Belongs to the acylphosphatase family
FEM46_06660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FEM46_06670	COG1733	regulation of RNA biosynthetic process
FEM46_06675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FEM46_06680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FEM46_06680	COG0072	phenylalanine-tRNA ligase activity
FEM46_06685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FEM46_06690	COG0572	uridine kinase
FEM46_06695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FEM46_06710	COG4841	protein insertion into membrane
FEM46_06720	COG0768	penicillin binding
FEM46_06725	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FEM46_06730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FEM46_06735	COG0457	Tetratricopeptide repeat
FEM46_06735	COG0705	Rhomboid family
FEM46_06745	COG1940	carbohydrate kinase activity
FEM46_06765	COG0584	glycerophosphoryl diester phosphodiesterase
FEM46_06770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FEM46_06775	COG0789	Transcriptional regulator
FEM46_06825	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FEM46_06835	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FEM46_06840	COG0006	proline dipeptidase activity
FEM46_06845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FEM46_06850	COG1302	Protein conserved in bacteria
FEM46_06855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FEM46_06860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FEM46_06865	COG1570	exodeoxyribonuclease VII activity
FEM46_06870	COG1722	exodeoxyribonuclease VII activity
FEM46_06875	COG0142	geranyltranstransferase activity
FEM46_06880	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FEM46_06885	COG1438	arginine binding
FEM46_06890	COG0497	DNA recombination
FEM46_06905	COG1732	Glycine betaine
FEM46_06910	COG1174	glycine betaine transport
FEM46_06920	COG0194	GDP metabolic process
FEM46_06925	COG1758	RNA polymerase activity
FEM46_06930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FEM46_06935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FEM46_06940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FEM46_06945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FEM46_06945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FEM46_06950	COG0631	protein serine/threonine phosphatase activity
FEM46_06955	COG2815	serine threonine protein kinase
FEM46_06955	COG0515	serine threonine protein kinase
FEM46_06960	COG1162	GTPase activity
FEM46_06965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FEM46_06970	COG1564	THIamine pyrophosphokinase
FEM46_06980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FEM46_06985	COG1302	Protein conserved in bacteria
FEM46_06990	COG1461	Dihydroxyacetone kinase
FEM46_06995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FEM46_07000	COG0416	fatty acid biosynthetic process
FEM46_07005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FEM46_07010	COG0571	ribonuclease III activity
FEM46_07015	COG1196	nuclear chromosome segregation
FEM46_07020	COG0552	protein localization to endoplasmic reticulum
FEM46_07025	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FEM46_07030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FEM46_07035	COG0228	four-way junction DNA binding
FEM46_07040	COG1837	Belongs to the UPF0109 family
FEM46_07045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FEM46_07050	COG0336	Belongs to the RNA methyltransferase TrmD family
FEM46_07055	COG0335	large ribosomal subunit rRNA binding
FEM46_07090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FEM46_07090	COG0512	Glutamine amidotransferase of anthranilate synthase
FEM46_07095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FEM46_07100	COG0134	indole-3-glycerol-phosphate synthase activity
FEM46_07105	COG0135	phosphoribosylanthranilate isomerase activity
FEM46_07110	COG0133	tryptophan synthase activity
FEM46_07115	COG0159	tryptophan synthase activity
FEM46_07140	COG1063	alcohol dehydrogenase
FEM46_07150	COG0300	oxidoreductase activity
FEM46_07160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FEM46_07165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FEM46_07170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FEM46_07175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FEM46_07180	COG1028	Short-chain dehydrogenase reductase Sdr
FEM46_07185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FEM46_07200	COG0439	Biotin carboxylase
FEM46_07215	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FEM46_07225	COG1811	Na channel or pump
FEM46_07230	COG0583	DNA-binding transcription factor activity
FEM46_07235	COG1607	acyl-coa hydrolase
FEM46_07240	COG1162	GTPase activity
FEM46_07255	COG0477	Major facilitator Superfamily
FEM46_07290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FEM46_07295	COG3397	chitin binding
FEM46_07300	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FEM46_07310	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FEM46_07320	COG3152	Membrane
FEM46_07325	COG1597	lipid kinase activity
FEM46_07340	COG2261	transglycosylase associated protein
FEM46_07345	COG3237	CsbD-like
FEM46_07360	COG1942	4-Oxalocrotonate Tautomerase
FEM46_07400	COG0531	amino acid
FEM46_07405	COG0561	phosphatase activity
FEM46_07410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FEM46_07410	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FEM46_07430	COG2017	converts alpha-aldose to the beta-anomer
FEM46_07435	COG1304	FMN binding
FEM46_07460	COG1199	ATP-dependent helicase activity
FEM46_07460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FEM46_07475	COG0017	Asparaginyl-tRNA synthetase
FEM46_07490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FEM46_07495	COG2011	ABC-type metal ion transport system permease component
FEM46_07500	COG1464	Belongs to the NlpA lipoprotein family
FEM46_07510	COG1177	transmembrane transport
FEM46_07515	COG1840	ABC-type Fe3 transport system, periplasmic component
FEM46_07530	COG3331	DNA recombination
FEM46_07535	COG4474	Belongs to the UPF0398 family
FEM46_07540	COG3599	regulation of cell shape
FEM46_07550	COG0116	Belongs to the methyltransferase superfamily
FEM46_07555	COG1073	alpha beta
FEM46_07565	COG1216	Glycosyl transferase, family 2
FEM46_07585	COG1619	proteins homologs of microcin C7 resistance protein MccF
FEM46_07610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FEM46_07625	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FEM46_07630	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FEM46_07635	COG0564	pseudouridine synthase activity
FEM46_07640	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FEM46_07645	COG0505	Belongs to the CarA family
FEM46_07650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FEM46_07665	COG5646	InterPro IPR014922
FEM46_07690	COG1131	(ABC) transporter
FEM46_07695	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
FEM46_07710	COG1307	EDD domain protein, DegV family
FEM46_07770	COG1113	amino acid transport
FEM46_07785	COG1620	l-lactate permease
FEM46_07795	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FEM46_07820	COG1846	Transcriptional regulator
FEM46_07825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FEM46_07860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FEM46_07865	COG1227	inorganic diphosphatase activity
FEM46_07870	COG0583	DNA-binding transcription factor activity
FEM46_07880	COG0187	DNA topoisomerase II activity
FEM46_07885	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FEM46_07895	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FEM46_07900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FEM46_07905	COG4974	Belongs to the 'phage' integrase family
FEM46_07910	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FEM46_07915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FEM46_07920	COG0758	DNA mediated transformation
FEM46_07925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FEM46_07930	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FEM46_07940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FEM46_07945	COG0583	DNA-binding transcription factor activity
FEM46_07965	COG2814	Major facilitator Superfamily
FEM46_07970	COG0793	Belongs to the peptidase S41A family
FEM46_07970	COG3409	Peptidoglycan-binding domain 1 protein
FEM46_07975	COG4479	Belongs to the UPF0346 family
FEM46_07980	COG4698	Protein conserved in bacteria
FEM46_07985	COG2755	lipolytic protein G-D-S-L family
FEM46_07990	COG1307	EDD domain protein, DegV family
FEM46_07995	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FEM46_08000	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FEM46_08005	COG0488	(ABC) transporter
FEM46_08015	COG0617	tRNA 3'-terminal CCA addition
FEM46_08020	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FEM46_08025	COG0561	phosphatase activity
FEM46_08030	COG0457	Tetratricopeptide repeat
FEM46_08045	COG1160	GTP binding
FEM46_08050	COG0539	negative regulation of cytoplasmic translation
FEM46_08055	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FEM46_08065	COG0514	ATP-dependent DNA helicase (RecQ)
FEM46_08075	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
FEM46_08080	COG1187	pseudouridine synthase activity
FEM46_08085	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FEM46_08090	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FEM46_08100	COG4974	Belongs to the 'phage' integrase family
FEM46_08105	COG2996	Protein conserved in bacteria
FEM46_08120	COG0205	6-phosphofructokinase activity
FEM46_08125	COG0587	DNA-directed DNA polymerase activity
FEM46_08135	COG0542	response to heat
FEM46_08145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FEM46_08150	COG2384	SAM-dependent methyltransferase
FEM46_08180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FEM46_08180	COG0574	Belongs to the PEP-utilizing enzyme family
FEM46_08190	COG1846	Transcriptional regulator
FEM46_08210	COG2217	Heavy metal translocating P-type atpase
FEM46_08215	COG0148	phosphopyruvate hydratase activity
FEM46_08220	COG0477	Major facilitator Superfamily
FEM46_08230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FEM46_08235	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEM46_08240	COG1349	DNA-binding transcription factor activity
FEM46_08250	COG1393	Belongs to the ArsC family
FEM46_08270	COG0546	phosphoglycolate phosphatase activity
FEM46_08300	COG0583	DNA-binding transcription factor activity
FEM46_08305	COG0604	alcohol dehydrogenase
FEM46_08315	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEM46_08320	COG2197	response regulator
FEM46_08325	COG4585	Histidine kinase
FEM46_08335	COG1131	(ABC) transporter
FEM46_08345	COG0519	Catalyzes the synthesis of GMP from XMP
FEM46_08360	COG1131	(ABC) transporter
FEM46_08380	COG1131	(ABC) transporter
FEM46_08385	COG1725	Transcriptional regulator
FEM46_08395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FEM46_08400	COG0358	DNA primase activity
FEM46_08405	COG0751	glycine-tRNA ligase activity
FEM46_08410	COG0752	glycyl-tRNA synthetase alpha subunit
FEM46_08415	COG1381	Involved in DNA repair and RecF pathway recombination
FEM46_08420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FEM46_08425	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FEM46_08430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FEM46_08435	COG1702	phosphate starvation-inducible protein PhoH
FEM46_08440	COG1610	YqeY-like protein
FEM46_08445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FEM46_08450	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FEM46_08455	COG1028	Short-chain dehydrogenase reductase Sdr
FEM46_08460	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FEM46_08470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FEM46_08480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FEM46_08485	COG0124	histidyl-tRNA synthetase
FEM46_08490	COG4991	sh3 domain protein
FEM46_08490	COG0860	N-Acetylmuramoyl-L-alanine amidase
FEM46_08490	COG3103	Sh3 type 3 domain protein
FEM46_08500	COG0546	phosphoglycolate phosphatase activity
FEM46_08505	COG1490	D-aminoacyl-tRNA deacylase activity
FEM46_08510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FEM46_08520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FEM46_08525	COG2264	protein methyltransferase activity
FEM46_08530	COG2094	Belongs to the DNA glycosylase MPG family
FEM46_08545	COG0481	GTPase activity
FEM46_08550	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FEM46_08555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FEM46_08560	COG1696	Membrane protein involved in D-alanine export
FEM46_08565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FEM46_08575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FEM46_08580	COG0484	heat shock protein binding
FEM46_08585	COG0443	Heat shock 70 kDa protein
FEM46_08590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FEM46_08595	COG1420	regulation of RNA biosynthetic process
FEM46_08600	COG3527	Alpha-acetolactate decarboxylase
FEM46_08605	COG0196	riboflavin kinase activity
FEM46_08610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FEM46_08615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FEM46_08620	COG0287	Prephenate dehydrogenase
FEM46_08625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FEM46_08635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FEM46_08640	COG0738	Major facilitator superfamily
FEM46_08645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FEM46_08650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FEM46_08660	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FEM46_08665	COG0195	Participates in both transcription termination and antitermination
FEM46_08670	COG0779	Required for maturation of 30S ribosomal subunits
FEM46_08675	COG2176	DNA-directed DNA polymerase activity
FEM46_08680	COG0442	prolyl-tRNA aminoacylation
FEM46_08685	COG0750	zinc metalloprotease
FEM46_08690	COG4589	Belongs to the CDS family
FEM46_08695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FEM46_08700	COG0233	cytoplasmic translational termination
FEM46_08705	COG0528	UMP kinase activity
FEM46_08710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FEM46_08715	COG0052	Belongs to the universal ribosomal protein uS2 family
FEM46_08725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FEM46_08730	COG2827	Endonuclease containing a URI domain
FEM46_08735	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FEM46_08740	COG0204	Acyl-transferase
FEM46_08745	COG3763	UPF0154 protein
FEM46_08750	COG4224	UPF0291 protein
FEM46_08755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FEM46_08770	COG3425	synthase
FEM46_08785	COG0463	Glycosyl transferase, family 2
FEM46_08850	COG0393	Putative heavy-metal-binding
FEM46_08865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FEM46_08870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FEM46_08870	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FEM46_08875	COG5416	Lipopolysaccharide assembly protein A domain
FEM46_08880	COG0300	oxidoreductase activity
FEM46_08885	COG1234	tRNA 3'-trailer cleavage
FEM46_08895	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FEM46_08900	COG1349	DNA-binding transcription factor activity
FEM46_08905	COG1105	Belongs to the carbohydrate kinase PfkB family
FEM46_08910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FEM46_08910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEM46_08910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FEM46_08915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FEM46_08940	COG0297	glycogen (starch) synthase activity
FEM46_08945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FEM46_08950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FEM46_08960	COG0489	protein tyrosine kinase activity
FEM46_08970	COG0322	excinuclease ABC activity
FEM46_08975	COG1126	abc transporter atp-binding protein
FEM46_08980	COG0765	amino acid transport
FEM46_09000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FEM46_09005	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FEM46_09010	COG0544	peptidyl-prolyl cis-trans isomerase activity
FEM46_09015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FEM46_09040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FEM46_09045	COG0268	Binds directly to 16S ribosomal RNA
FEM46_09050	COG1466	dna polymerase III delta subunit
FEM46_09055	COG0658	competence protein
FEM46_09055	COG2333	competence protein COMEC
FEM46_09060	COG2131	deaminase
FEM46_09065	COG1596	polysaccharide export
FEM46_09065	COG1555	photosystem II stabilization
FEM46_09070	COG3480	Lon protease (S16) C-terminal proteolytic domain
FEM46_09075	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FEM46_09080	COG0742	ribosomal rna small subunit methyltransferase
FEM46_09085	COG4471	UPF0298 protein
FEM46_09090	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FEM46_09095	COG0772	Belongs to the SEDS family
FEM46_09135	COG0483	inositol monophosphate 1-phosphatase activity
FEM46_09140	COG4476	Belongs to the UPF0223 family
FEM46_09145	COG0039	L-malate dehydrogenase activity
FEM46_09175	COG0242	peptide deformylase activity
FEM46_09190	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FEM46_09195	COG1597	lipid kinase activity
FEM46_09205	COG1388	LysM domain
FEM46_09205	COG3584	3D domain protein
FEM46_09210	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FEM46_09215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FEM46_09245	COG0569	domain protein
FEM46_09250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FEM46_09255	COG0482	sulfurtransferase activity
FEM46_09265	COG1104	cysteine desulfurase activity
FEM46_09270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FEM46_09280	COG0494	nUDIX hydrolase
FEM46_09285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FEM46_09295	COG3279	Response regulator of the LytR AlgR family
FEM46_09310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FEM46_09315	COG3599	regulation of cell shape
FEM46_09325	COG0762	integral membrane protein
FEM46_09330	COG1799	cell septum assembly
FEM46_09345	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FEM46_09350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FEM46_09355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FEM46_09360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FEM46_09375	COG0275	rRNA processing
FEM46_09380	COG2001	Belongs to the MraZ family
FEM46_09400	COG1674	ftsk spoiiie
FEM46_09405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FEM46_09415	COG1114	Component of the transport system for branched-chain amino acids
FEM46_09430	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FEM46_09435	COG0628	permease
FEM46_09445	COG2706	6-phosphogluconolactonase activity
FEM46_09450	COG3142	Participates in the control of copper homeostasis
FEM46_09455	COG0564	pseudouridine synthase activity
FEM46_09460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FEM46_09465	COG2357	RelA SpoT domain protein
FEM46_09475	COG1164	Oligoendopeptidase f
FEM46_09485	COG4862	establishment of competence for transformation
FEM46_09490	COG1393	Belongs to the ArsC family
FEM46_09495	COG1234	tRNA 3'-trailer cleavage
FEM46_09635	COG1098	S1 RNA binding domain
FEM46_09645	COG0586	Pfam SNARE associated Golgi protein
FEM46_09655	COG0647	UMP catabolic process
FEM46_09660	COG4470	Protein conserved in bacteria
FEM46_09665	COG0737	Belongs to the 5'-nucleotidase family
FEM46_09680	COG1113	amino acid transport
FEM46_09685	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FEM46_09690	COG0827	DNA restriction-modification system
FEM46_09720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FEM46_09730	COG0217	transcriptional regulatory protein
FEM46_09745	COG1609	Transcriptional regulator
FEM46_09750	COG0006	proline dipeptidase activity
FEM46_09755	COG0789	Transcriptional regulator
FEM46_09770	COG0668	transmembrane transport
FEM46_09775	COG1473	amidohydrolase
FEM46_09780	COG2171	N-acyltransferase activity
FEM46_09785	COG0517	IMP dehydrogenase activity
FEM46_09795	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FEM46_09800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FEM46_09805	COG1719	4-vinyl reductase, 4VR
FEM46_09810	COG3118	belongs to the thioredoxin family
FEM46_09815	COG1193	negative regulation of DNA recombination
FEM46_09825	COG3906	Belongs to the UPF0473 family
FEM46_09830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FEM46_09835	COG4472	Bacterial protein of unknown function (DUF965)
FEM46_09840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FEM46_09845	COG0513	Belongs to the DEAD box helicase family
FEM46_09850	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FEM46_09855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FEM46_09860	COG1862	Preprotein translocase
FEM46_09865	COG0343	queuine tRNA-ribosyltransferase activity
FEM46_09870	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FEM46_09875	COG2255	four-way junction helicase activity
FEM46_09880	COG0632	four-way junction helicase activity
FEM46_09910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FEM46_09915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FEM46_09920	COG1692	metallophosphoesterase
FEM46_09925	COG1418	mRNA catabolic process
FEM46_09930	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FEM46_09935	COG1058	Belongs to the CinA family
FEM46_09935	COG1546	Belongs to the CinA family
FEM46_09940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FEM46_09945	COG1426	Protein conserved in bacteria
FEM46_09950	COG0612	Peptidase, M16
FEM46_09955	COG0612	Peptidase, M16
FEM46_09960	COG0527	aspartate kinase activity
FEM46_09970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FEM46_09975	COG1126	abc transporter atp-binding protein
FEM46_09980	COG0765	amino acid transport
FEM46_09985	COG2894	cell division
FEM46_09990	COG0850	regulation of cytokinetic process
FEM46_10000	COG1792	Involved in formation and maintenance of cell shape
FEM46_10005	COG1077	Cell shape determining protein MreB Mrl
FEM46_10010	COG2003	Belongs to the UPF0758 family
FEM46_10015	COG0285	dihydrofolate synthase activity
FEM46_10020	COG0525	valine-tRNA ligase activity
FEM46_10030	COG1181	Belongs to the D-alanine--D-alanine ligase family
FEM46_10030	COG2918	glutathione biosynthetic process
FEM46_10035	COG0301	tRNA thio-modification
FEM46_10040	COG1104	cysteine desulfurase activity
FEM46_10050	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FEM46_10055	COG1956	GAF domain-containing protein
FEM46_10060	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FEM46_10065	COG4493	Belongs to the UPF0637 family
FEM46_10095	COG3716	PTS system mannose fructose sorbose family IID component
FEM46_10100	COG3715	PTS system
FEM46_10105	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_10110	COG1609	Transcriptional regulator
FEM46_10115	COG2918	glutathione biosynthetic process
FEM46_10115	COG0189	ligase activity
FEM46_10120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FEM46_10135	COG0589	response to stress
FEM46_10155	COG1181	Belongs to the D-alanine--D-alanine ligase family
FEM46_10175	COG1464	Belongs to the NlpA lipoprotein family
FEM46_10180	COG2011	ABC-type metal ion transport system permease component
FEM46_10185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FEM46_10190	COG0509	glycine decarboxylation via glycine cleavage system
FEM46_10195	COG0772	Belongs to the SEDS family
FEM46_10205	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FEM46_10210	COG1077	Cell shape determining protein MreB Mrl
FEM46_10220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FEM46_10225	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FEM46_10230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FEM46_10235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FEM46_10240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FEM46_10245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FEM46_10250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FEM46_10255	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FEM46_10260	COG0356	it plays a direct role in the translocation of protons across the membrane
FEM46_10265	COG2233	PERMEase
FEM46_10275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FEM46_10280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FEM46_10285	COG0009	L-threonylcarbamoyladenylate synthase
FEM46_10290	COG2890	protein-(glutamine-N5) methyltransferase activity
FEM46_10295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FEM46_10300	COG1435	thymidine kinase activity
FEM46_10305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FEM46_10310	COG3442	glutamine amidotransferase
FEM46_10315	COG1482	cell wall glycoprotein biosynthetic process
FEM46_10320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FEM46_10330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FEM46_10345	COG1132	(ABC) transporter
FEM46_10360	COG0726	polysaccharide deacetylase
FEM46_10490	COG2868	ribosomal protein
FEM46_10505	COG5484	DNA packaging
FEM46_10645	COG1396	sequence-specific DNA binding
FEM46_10685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FEM46_10745	COG4886	Leucine-rich repeat (LRR) protein
FEM46_10745	COG4932	domain protein
FEM46_10790	COG1132	(ABC) transporter
FEM46_10800	COG0577	efflux transmembrane transporter activity
FEM46_10800	COG1136	(ABC) transporter
FEM46_10810	COG0166	Belongs to the GPI family
FEM46_10815	COG4975	Glucose uptake
FEM46_10820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FEM46_10825	COG3850	Histidine kinase
FEM46_10825	COG5002	protein histidine kinase activity
FEM46_10830	COG0745	RESPONSE REGULATOR receiver
FEM46_10835	COG2848	UPF0210 protein
FEM46_10840	COG3830	Belongs to the UPF0237 family
FEM46_10865	COG0477	Major facilitator Superfamily
FEM46_10885	COG0791	NLP P60 protein
FEM46_10890	COG1522	sequence-specific DNA binding
FEM46_10905	COG3706	GGDEF domain
FEM46_10910	COG0488	(ABC) transporter
FEM46_10935	COG1263	PTS System
FEM46_10935	COG2190	(PTS) system
FEM46_10935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_10940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FEM46_10945	COG1307	EDD domain protein, DegV family
FEM46_10960	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FEM46_10975	COG4120	Belongs to the binding-protein-dependent transport system permease family
FEM46_10985	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEM46_10990	COG2084	Dehydrogenase
FEM46_10995	COG0861	Integral membrane protein TerC family
FEM46_11000	COG0110	maltose O-acetyltransferase activity
FEM46_11005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FEM46_11010	COG0140	phosphoribosyl-ATP diphosphatase activity
FEM46_11015	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FEM46_11020	COG0107	imidazoleglycerol-phosphate synthase activity
FEM46_11025	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FEM46_11030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FEM46_11035	COG0131	Imidazoleglycerol-phosphate dehydratase
FEM46_11040	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FEM46_11045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FEM46_11050	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FEM46_11055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FEM46_11080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FEM46_11095	COG3548	integral membrane protein
FEM46_11115	COG1368	sulfuric ester hydrolase activity
FEM46_11120	COG0584	glycerophosphoryl diester phosphodiesterase
FEM46_11130	COG0492	ferredoxin-NADP+ reductase activity
FEM46_11140	COG4932	domain protein
FEM46_11145	COG2326	polyphosphate kinase activity
FEM46_11150	COG0778	Nitroreductase
FEM46_11160	COG0328	RNA-DNA hybrid ribonuclease activity
FEM46_11165	COG4975	Glucose uptake
FEM46_11170	COG1940	carbohydrate kinase activity
FEM46_11180	COG1349	DNA-binding transcription factor activity
FEM46_11205	COG1609	Transcriptional regulator
FEM46_11210	COG1737	Transcriptional regulator
FEM46_11215	COG0673	inositol 2-dehydrogenase activity
FEM46_11220	COG0673	inositol 2-dehydrogenase activity
FEM46_11225	COG0025	NhaP-type Na H and K H
FEM46_11230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FEM46_11235	COG1335	isochorismatase
FEM46_11245	COG1131	(ABC) transporter
FEM46_11250	COG1725	Transcriptional regulator
FEM46_11295	COG0028	Belongs to the TPP enzyme family
FEM46_11305	COG1073	alpha beta
FEM46_11310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FEM46_11315	COG0626	cystathionine gamma-synthase activity
FEM46_11345	COG0095	Lipoate-protein ligase
FEM46_11350	COG1705	Flagellar rod assembly protein muramidase FlgJ
FEM46_11360	COG3716	PTS system mannose fructose sorbose family IID component
FEM46_11365	COG3715	PTS system
FEM46_11370	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_11375	COG2188	Transcriptional regulator
FEM46_11380	COG0589	response to stress
FEM46_11385	COG0564	pseudouridine synthase activity
FEM46_11390	COG1396	sequence-specific DNA binding
FEM46_11405	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FEM46_11415	COG2188	Transcriptional regulator
FEM46_11420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FEM46_11430	COG1418	mRNA catabolic process
FEM46_11460	COG1253	flavin adenine dinucleotide binding
FEM46_11465	COG1780	Probably involved in ribonucleotide reductase function
FEM46_11470	COG0025	NhaP-type Na H and K H
FEM46_11475	COG2814	Major facilitator Superfamily
FEM46_11480	COG0789	Transcriptional regulator
FEM46_11485	COG0604	alcohol dehydrogenase
FEM46_11495	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FEM46_11505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEM46_11510	COG0436	Aminotransferase
FEM46_11515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FEM46_11530	COG0583	DNA-binding transcription factor activity
FEM46_11535	COG0702	epimerase
FEM46_11545	COG1074	ATP-dependent DNA helicase activity
FEM46_11550	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FEM46_11560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FEM46_11565	COG0284	orotidine-5'-phosphate decarboxylase activity
FEM46_11570	COG0167	dihydroorotate dehydrogenase activity
FEM46_11575	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FEM46_11580	COG0505	Belongs to the CarA family
FEM46_11585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FEM46_11590	COG0540	Belongs to the ATCase OTCase family
FEM46_11595	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FEM46_11600	COG2508	Transcriptional regulator
FEM46_11605	COG2233	PERMEase
FEM46_11610	COG2252	PERMEase
FEM46_11630	COG1215	transferase activity, transferring glycosyl groups
FEM46_11640	COG0151	Belongs to the GarS family
FEM46_11645	COG0138	bifunctional purine biosynthesis protein purh
FEM46_11650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FEM46_11655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FEM46_11665	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FEM46_11670	COG0047	phosphoribosylformylglycinamidine synthase activity
FEM46_11675	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FEM46_11680	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FEM46_11685	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FEM46_11695	COG1053	succinate dehydrogenase
FEM46_11695	COG0431	NADPH-dependent FMN reductase
FEM46_11695	COG3976	FMN-binding domain protein
FEM46_11700	COG3976	FMN-binding domain protein
FEM46_11700	COG0431	NADPH-dependent FMN reductase
FEM46_11700	COG1053	succinate dehydrogenase
FEM46_11705	COG0095	Lipoate-protein ligase
FEM46_11710	COG2365	Tyrosine phosphatase family
FEM46_11730	COG1136	(ABC) transporter
FEM46_11745	COG1725	Transcriptional regulator
FEM46_11750	COG1131	(ABC) transporter
FEM46_11760	COG0589	response to stress
FEM46_11770	COG2246	polysaccharide biosynthetic process
FEM46_11790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FEM46_11820	COG0561	phosphatase activity
FEM46_11830	COG0110	maltose O-acetyltransferase activity
FEM46_11835	COG1051	belongs to the nudix hydrolase family
FEM46_11865	COG1827	regulation of RNA biosynthetic process
FEM46_11870	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FEM46_11875	COG1309	transcriptional regulator
FEM46_11885	COG1131	(ABC) transporter
FEM46_11890	COG3048	D-serine ammonia-lyase activity
FEM46_11895	COG2723	6-phospho-beta-galactosidase activity
FEM46_11900	COG2723	6-phospho-beta-galactosidase activity
FEM46_11905	COG1447	Phosphotransferase system cellobiose-specific component IIA
FEM46_11910	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEM46_11915	COG2188	Transcriptional regulator
FEM46_11920	COG1216	Glycosyl transferase, family 2
FEM46_11935	COG0561	phosphatase activity
FEM46_11940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FEM46_11965	COG0716	FMN binding
FEM46_11985	COG0710	3-dehydroquinate dehydratase activity
FEM46_11990	COG0531	amino acid
FEM46_12035	COG4720	Psort location CytoplasmicMembrane, score
FEM46_12040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FEM46_12055	COG4990	cell redox homeostasis
FEM46_12075	COG1811	Na channel or pump
FEM46_12080	COG0789	Transcriptional regulator
FEM46_12080	COG4978	Transcriptional regulator
FEM46_12095	COG0577	efflux transmembrane transporter activity
FEM46_12100	COG1136	(ABC) transporter
FEM46_12145	COG2814	Major facilitator Superfamily
FEM46_12155	COG2814	Major facilitator Superfamily
FEM46_12165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FEM46_12170	COG2855	membrane
FEM46_12175	COG0583	DNA-binding transcription factor activity
FEM46_12185	COG0438	transferase activity, transferring glycosyl groups
FEM46_12205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FEM46_12215	COG4152	abc transporter atp-binding protein
FEM46_12225	COG4221	oxidoreductase activity
FEM46_12240	COG0789	Transcriptional regulator
FEM46_12260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FEM46_12290	COG0456	acetyltransferase
FEM46_12320	COG0583	DNA-binding transcription factor activity
FEM46_12330	COG1063	alcohol dehydrogenase
FEM46_12335	COG1028	Short-chain dehydrogenase reductase Sdr
FEM46_12345	COG0589	response to stress
FEM46_12350	COG0110	maltose O-acetyltransferase activity
FEM46_12355	COG1011	Hydrolase
FEM46_12370	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FEM46_12380	COG0667	Aldo Keto reductase
FEM46_12385	COG1132	(ABC) transporter
FEM46_12390	COG1132	(ABC) transporter
FEM46_12395	COG2814	Major facilitator Superfamily
FEM46_12410	COG1511	domain protein
FEM46_12410	COG1511	domain protein
FEM46_12420	COG0640	Transcriptional regulator
FEM46_12450	COG0488	(ABC) transporter
FEM46_12455	COG0561	phosphatase activity
FEM46_12465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FEM46_12480	COG2270	Major facilitator Superfamily
FEM46_12520	COG2200	EAL domain
FEM46_12530	COG1328	CTP reductase activity
FEM46_12540	COG0242	peptide deformylase activity
FEM46_12550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FEM46_12570	COG0583	DNA-binding transcription factor activity
FEM46_12580	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FEM46_12640	COG0697	spore germination
FEM46_12665	COG1940	carbohydrate kinase activity
FEM46_12670	COG3409	Peptidoglycan-binding domain 1 protein
FEM46_12675	COG1132	(ABC) transporter
FEM46_12685	COG0778	Nitroreductase
FEM46_12690	COG1263	PTS System
FEM46_12690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_12690	COG2190	(PTS) system
FEM46_12700	COG4120	Belongs to the binding-protein-dependent transport system permease family
FEM46_12735	COG0410	ABC transporter
FEM46_12750	COG0559	Belongs to the binding-protein-dependent transport system permease family
FEM46_12765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FEM46_12765	COG5549	protein import
FEM46_12770	COG2246	polysaccharide biosynthetic process
FEM46_12780	COG1914	H( )-stimulated, divalent metal cation uptake system
FEM46_12800	COG0640	Transcriptional regulator
FEM46_12815	COG1136	(ABC) transporter
FEM46_12815	COG0577	efflux transmembrane transporter activity
FEM46_12850	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEM46_12855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEM46_12860	COG2723	6-phospho-beta-galactosidase activity
FEM46_12870	COG0789	Transcriptional regulator
FEM46_12875	COG0741	lytic transglycosylase activity
FEM46_12895	COG0803	Belongs to the bacterial solute-binding protein 9 family
FEM46_12920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FEM46_12935	COG4221	oxidoreductase activity
FEM46_12965	COG1028	Short-chain dehydrogenase reductase Sdr
FEM46_12980	COG1132	(ABC) transporter
FEM46_12985	COG1132	(ABC) transporter
FEM46_12995	COG1473	amidohydrolase
FEM46_13000	COG1028	Short-chain dehydrogenase reductase Sdr
FEM46_13015	COG0531	amino acid
FEM46_13040	COG2217	Heavy metal translocating P-type atpase
FEM46_13100	COG1063	alcohol dehydrogenase
FEM46_13140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEM46_13145	COG1733	regulation of RNA biosynthetic process
FEM46_13150	COG2814	Major facilitator Superfamily
FEM46_13160	COG0367	asparagine synthase
FEM46_13165	COG3279	Response regulator of the LytR AlgR family
FEM46_13180	COG1309	transcriptional regulator
FEM46_13190	COG1012	belongs to the aldehyde dehydrogenase family
FEM46_13205	COG1733	regulation of RNA biosynthetic process
FEM46_13210	COG0300	oxidoreductase activity
FEM46_13230	COG4989	oxidoreductase activity
FEM46_13245	COG0477	Major facilitator Superfamily
FEM46_13260	COG1120	ATPase activity
FEM46_13265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FEM46_13270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FEM46_13275	COG1309	transcriptional regulator
FEM46_13285	COG4221	oxidoreductase activity
FEM46_13290	COG0110	maltose O-acetyltransferase activity
FEM46_13295	COG1028	Short-chain dehydrogenase reductase Sdr
FEM46_13335	COG0481	GTPase activity
FEM46_13350	COG2816	NAD+ diphosphatase activity
FEM46_13370	COG0783	Belongs to the Dps family
FEM46_13380	COG2723	6-phospho-beta-galactosidase activity
FEM46_13385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEM46_13410	COG0789	Transcriptional regulator
FEM46_13430	COG0693	protein deglycase activity
FEM46_13455	COG1136	(ABC) transporter
FEM46_13455	COG0577	efflux transmembrane transporter activity
FEM46_13465	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FEM46_13470	COG1705	Flagellar rod assembly protein muramidase FlgJ
FEM46_13490	COG1376	ErfK ybiS ycfS ynhG family protein
FEM46_13495	COG0656	L-ascorbic acid biosynthetic process
FEM46_13510	COG0477	Major facilitator Superfamily
FEM46_13540	COG0588	phosphoglycerate mutase activity
FEM46_13545	COG0628	permease
FEM46_13550	COG1940	carbohydrate kinase activity
FEM46_13550	COG1846	Transcriptional regulator
FEM46_13560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FEM46_13570	COG0515	serine threonine protein kinase
FEM46_13570	COG2815	serine threonine protein kinase
FEM46_13610	COG1247	-acetyltransferase
FEM46_13615	COG1686	Belongs to the peptidase S11 family
FEM46_13635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FEM46_13650	COG0012	GTP binding
FEM46_13655	COG4481	Protein conserved in bacteria
FEM46_13660	COG1475	DNA binding
FEM46_13665	COG1192	Involved in chromosome partitioning
FEM46_13675	COG0357	Ribosomal RNA small subunit methyltransferase G
FEM46_13680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FEM46_13695	COG0583	DNA-binding transcription factor activity
FEM46_13700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEM46_13705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FEM46_13710	COG0765	amino acid transport
FEM46_13715	COG1126	abc transporter atp-binding protein
FEM46_13720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FEM46_13745	COG2190	(PTS) system
FEM46_13745	COG1263	PTS System
FEM46_13745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_13755	COG1609	Transcriptional regulator
FEM46_13770	COG0390	transport system, permease component
FEM46_13775	COG4619	ABC transporter
FEM46_13780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FEM46_13795	COG1263	PTS System
FEM46_13795	COG2190	(PTS) system
FEM46_13795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_13810	COG0583	DNA-binding transcription factor activity
FEM46_13820	COG0561	phosphatase activity
FEM46_13830	COG0383	alpha-mannosidase activity
FEM46_13835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FEM46_13835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEM46_13835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FEM46_13840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FEM46_13845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEM46_13845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FEM46_13845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FEM46_13850	COG3711	transcriptional antiterminator
FEM46_13850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEM46_13865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_13865	COG1263	PTS System
FEM46_13865	COG2190	(PTS) system
FEM46_13895	COG0735	belongs to the Fur family
FEM46_13930	COG1307	EDD domain protein, DegV family
FEM46_13940	COG2738	Putative neutral zinc metallopeptidase
FEM46_14170	COG1396	sequence-specific DNA binding
FEM46_14210	COG1233	COG1233 Phytoene dehydrogenase and related
FEM46_14215	COG1562	ergosterol biosynthetic process
FEM46_14225	COG1929	Belongs to the glycerate kinase type-1 family
FEM46_14240	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FEM46_14245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FEM46_14250	COG0516	GMP reductase activity
FEM46_14255	COG2365	Tyrosine phosphatase family
FEM46_14260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FEM46_14270	COG0531	amino acid
FEM46_14275	COG3158	transport of potassium into the cell
FEM46_14280	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FEM46_14285	COG0628	permease
FEM46_14290	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FEM46_14305	COG1272	protein, Hemolysin III
FEM46_14310	COG0640	Transcriptional regulator
FEM46_14335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FEM46_14345	COG0302	gtp cyclohydrolase
FEM46_14350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FEM46_14365	COG0803	Belongs to the bacterial solute-binding protein 9 family
FEM46_14370	COG2814	Major facilitator Superfamily
FEM46_14400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FEM46_14405	COG1882	Formate acetyltransferase
FEM46_14410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FEM46_14420	COG2151	metal-sulfur cluster biosynthetic enzyme
FEM46_14425	COG4989	oxidoreductase activity
FEM46_14460	COG2217	Heavy metal translocating P-type atpase
FEM46_14480	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FEM46_14485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FEM46_14500	COG1113	amino acid transport
FEM46_14510	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FEM46_14525	COG1393	Belongs to the ArsC family
FEM46_14530	COG3189	MarR family transcriptional regulator
FEM46_14540	COG1194	a g-specific adenine glycosylase
FEM46_14555	COG0071	Belongs to the small heat shock protein (HSP20) family
FEM46_14575	COG0697	spore germination
FEM46_14590	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FEM46_14615	COG0477	Major facilitator Superfamily
FEM46_14675	COG0737	Belongs to the 5'-nucleotidase family
FEM46_14685	COG0656	L-ascorbic acid biosynthetic process
FEM46_14705	COG1968	undecaprenyl-diphosphatase activity
FEM46_14710	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FEM46_14745	COG2207	Transcriptional regulator
FEM46_14770	COG0076	glutamate decarboxylase activity
FEM46_14810	COG1309	transcriptional regulator
FEM46_14820	COG2226	methyltransferase
FEM46_14840	COG2217	Heavy metal translocating P-type atpase
FEM46_14845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FEM46_14850	COG3118	belongs to the thioredoxin family
FEM46_14855	COG1937	Protein conserved in bacteria
FEM46_14875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FEM46_14880	COG3590	peptidase
FEM46_14905	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEM46_14955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FEM46_14970	COG1114	Component of the transport system for branched-chain amino acids
FEM46_14980	COG1874	Beta-galactosidase
FEM46_14985	COG1609	Transcriptional regulator
FEM46_14995	COG0477	Major facilitator Superfamily
FEM46_15015	COG2184	nucleotidyltransferase activity
FEM46_15020	COG2944	sequence-specific DNA binding
FEM46_15025	COG1609	Transcriptional regulator
FEM46_15030	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
FEM46_15035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FEM46_15040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FEM46_15060	COG2190	(PTS) system
FEM46_15060	COG2211	Major facilitator Superfamily
FEM46_15065	COG2017	converts alpha-aldose to the beta-anomer
FEM46_15070	COG1609	Transcriptional regulator
FEM46_15075	COG0667	Aldo Keto reductase
FEM46_15095	COG0710	3-dehydroquinate dehydratase activity
FEM46_15100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FEM46_15105	COG0583	DNA-binding transcription factor activity
FEM46_15110	COG2271	Major facilitator Superfamily
FEM46_15125	COG1028	Short-chain dehydrogenase reductase Sdr
FEM46_15140	COG2271	Major facilitator Superfamily
FEM46_15150	COG2267	carboxylic ester hydrolase activity
FEM46_15160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEM46_15165	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FEM46_15170	COG2971	BadF BadG BcrA BcrD
FEM46_15180	COG2723	6-phospho-beta-galactosidase activity
FEM46_15190	COG3711	transcriptional antiterminator
FEM46_15195	COG2723	6-phospho-beta-galactosidase activity
FEM46_15200	COG2723	6-phospho-beta-galactosidase activity
FEM46_15205	COG2190	(PTS) system
FEM46_15205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_15205	COG1263	PTS System
FEM46_15240	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FEM46_15255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FEM46_15260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FEM46_15265	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FEM46_15265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FEM46_15265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FEM46_15270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FEM46_15285	COG3711	transcriptional antiterminator
FEM46_15295	COG3775	system Galactitol-specific IIC component
FEM46_15300	COG3414	Phosphotransferase system galactitol-specific IIB component
FEM46_15310	COG1349	DNA-binding transcription factor activity
FEM46_15315	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FEM46_15325	COG0110	maltose O-acetyltransferase activity
FEM46_15330	COG2160	L-arabinose isomerase activity
FEM46_15350	COG1609	Transcriptional regulator
FEM46_15355	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FEM46_15385	COG2261	transglycosylase associated protein
FEM46_15395	COG1393	Belongs to the ArsC family
FEM46_15415	COG4512	PFAM Accessory gene regulator B
FEM46_15430	COG1304	FMN binding
FEM46_15435	COG0028	Belongs to the TPP enzyme family
FEM46_15440	COG1959	2 iron, 2 sulfur cluster binding
FEM46_15445	COG0028	Belongs to the TPP enzyme family
FEM46_15460	COG0235	Class ii aldolase
FEM46_15465	COG4806	L-rhamnose isomerase
FEM46_15470	COG3254	rhamnose metabolic process
FEM46_15475	COG1070	Carbohydrate kinase
FEM46_15480	COG2814	Major facilitator Superfamily
FEM46_15485	COG2207	Transcriptional regulator
FEM46_15490	COG1349	DNA-binding transcription factor activity
FEM46_15505	COG2826	transposase and inactivated derivatives, IS30 family
FEM46_15530	COG4975	Glucose uptake
FEM46_15535	COG1869	D-ribose catabolic process
FEM46_15545	COG1609	Transcriptional regulator
FEM46_15550	COG1454	alcohol dehydrogenase
FEM46_15550	COG1012	belongs to the aldehyde dehydrogenase family
FEM46_15560	COG1695	Transcriptional regulator
FEM46_15565	COG3479	Phenolic acid decarboxylase
FEM46_15580	COG1307	EDD domain protein, DegV family
FEM46_15620	COG0445	tRNA wobble uridine modification
FEM46_15625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FEM46_15630	COG1847	R3H domain protein
FEM46_15640	COG4166	transmembrane transport
FEM46_15645	COG0706	membrane insertase activity
FEM46_15650	COG0594	ribonuclease P activity
FEM46_15655	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FEM46_15680	COG1192	Involved in chromosome partitioning
FEM46_15695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FEM46_15705	COG3716	PTS system mannose fructose sorbose family IID component
FEM46_15710	COG3715	PTS system
FEM46_15715	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEM46_15720	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEM46_15775	COG1418	mRNA catabolic process
FEM46_15865	COG1914	H( )-stimulated, divalent metal cation uptake system
FEM46_15885	COG1113	amino acid transport
FEM46_15890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FEM46_15900	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FEM46_15905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FEM46_15910	COG0860	N-Acetylmuramoyl-L-alanine amidase
FEM46_15925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FEM46_16050	COG0542	response to heat
FEM46_16090	COG0489	protein tyrosine kinase activity
FEM46_16095	COG4464	protein tyrosine phosphatase activity
FEM46_16110	COG0438	transferase activity, transferring glycosyl groups
FEM46_16115	COG0438	transferase activity, transferring glycosyl groups
FEM46_16120	COG2826	transposase and inactivated derivatives, IS30 family
FEM46_16135	COG1215	transferase activity, transferring glycosyl groups
FEM46_16170	COG1215	transferase activity, transferring glycosyl groups
FEM46_16200	COG2801	Transposase and inactivated derivatives
FEM46_16205	COG3275	phosphorelay sensor kinase activity
FEM46_16210	COG3279	Response regulator of the LytR AlgR family
FEM46_16220	COG1346	cytolysis
FEM46_16235	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FEM46_16255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FEM46_16290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FEM46_16300	COG1192	Involved in chromosome partitioning
FEM46_16360	COG0551	DNA topoisomerase type I activity
FEM46_16360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FEM46_16390	COG0693	protein deglycase activity
FEM46_16420	COG2826	transposase and inactivated derivatives, IS30 family