locus-tag class description LBP_cg0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) LBP_cg0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) LBP_cg0003 ENOG410848D S4 domain protein YaaA LBP_cg0004 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) LBP_cg0005 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LBP_cg0008 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) LBP_cg0009 ENOG4108UUM single-stranded DNA-binding protein LBP_cg0010 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) LBP_cg0012 ENOG4105K9Q Binds to the 23S rRNA (By similarity) LBP_cg0013 ENOG4105CDU Replicative dna helicase LBP_cg0014 ENOG410605W Major Facilitator LBP_cg0015 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) LBP_cg0016 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) LBP_cg0017 ENOG4108J59 Extracellular solute-binding protein, family 5 LBP_cg0018 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) LBP_cg0019 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) LBP_cg0021 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) LBP_cg0023 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) LBP_cg0025 ENOG4107URF beta-phospho-glucomutase LBP_cg0026 ENOG4105C71 hydrolase family 65, central catalytic LBP_cg0028 ENOG4105VEQ Cold shock protein LBP_cg0030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LBP_cg0031 ENOG4105BZU Histidine kinase LBP_cg0034 ENOG4105Q2H domain protein LBP_cg0035 ENOG4105C0H protease LBP_cg0036 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) LBP_cg0038 ENOG4107RGH Aldehyde dehydrogenase LBP_cg0039 ENOG4108HFV LBP_cg0040 ENOG4108RG0 uracil-dna glycosylase LBP_cg0045 ENOG4107EFR Flavocytochrome c LBP_cg0046 ENOG4107QPK )-transporter LBP_cg0049 ENOG4108UXE Protein tyrosine phosphatase LBP_cg0050 ENOG4105DTD Dehydrogenase LBP_cg0052 ENOG4108TVJ Nitroreductase LBP_cg0053 ENOG4105G9B Transcriptional regulator LBP_cg0054 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 LBP_cg0055 ENOG4107QHE Choloylglycine hydrolase LBP_cg0057 ENOG4105M2Z protein tyrosine serine phosphatase LBP_cg0058 ENOG4105EFA 4-hydroxyphenylacetate LBP_cg0062 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) LBP_cg0069 ENOG4105CIS alcohol dehydrogenase LBP_cg0075 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) LBP_cg0076 ENOG4105D1Q UPF0246 protein LBP_cg0083 ENOG4108JJB ABC transporter LBP_cg0084 ENOG41082M7 Cobalt transport protein LBP_cg0085 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) LBP_cg0086 ENOG4105TV1 Transcriptional regulator LBP_cg0087 ENOG4105QUH Domain of unknown function (DUF2088) LBP_cg0088 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase LBP_cg0090 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) LBP_cg0091 ENOG4105DVM PP-loop domain protein LBP_cg0092 ENOG4105CIS alcohol dehydrogenase LBP_cg0093 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase LBP_cg0094 ENOG4105DWF phosphomethylpyrimidine kinase LBP_cg0095 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) LBP_cg0106 ENOG41067S9 phage shock protein C, PspC LBP_cg0115 ENOG4105DJ2 Major Facilitator Superfamily LBP_cg0117 ENOG4107S5I aldo keto reductase LBP_cg0122 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase LBP_cg0123 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) LBP_cg0124 ENOG4108JJB ABC transporter LBP_cg0125 ENOG4108V7D UPF0397 protein LBP_cg0127 ENOG4108TZY GntR Family Transcriptional Regulator LBP_cg0132 ENOG4105EWI Short-chain dehydrogenase reductase Sdr LBP_cg0133 ENOG4105CIG ABC transporter LBP_cg0136 ENOG4105C10 Electron transfer flavoprotein LBP_cg0137 ENOG4105X71 Membrane LBP_cg0139 ENOG4105CMT Dihydroxyacetone kinase LBP_cg0140 ENOG4105CMT Dihydroxyacetone kinase LBP_cg0141 ENOG4108UTZ Dihydroxyacetone kinase LBP_cg0142 ENOG4105VDH Dihydroxyacetone kinase LBP_cg0143 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) LBP_cg0145 ENOG4105FKQ transcriptional regulator LBP_cg0146 ENOG4105CG3 alpha amylase, catalytic region LBP_cg0148 ENOG4107FKK extracellular solute-binding protein family 1 LBP_cg0149 ENOG4105D56 permease protein LBP_cg0150 ENOG4105EG2 ABC transporter, permease LBP_cg0153 ENOG4108IJ9 (ABC) transporter LBP_cg0158 ENOG4105EVU fructokinase LBP_cg0159 ENOG4105DME alpha-galactosidase LBP_cg0160 ENOG4105C5Y PTS System LBP_cg0161 ENOG4108HKT sucrose-6-phosphate hydrolase LBP_cg0162 ENOG4105ETE Transcriptional regulator (LacI family LBP_cg0165 ENOG4105DFD Na H antiporter LBP_cg0176 ENOG4108JQ1 Dehydrogenase LBP_cg0177 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) LBP_cg0178 ENOG4105CVJ phosphoglycerate mutase LBP_cg0179 ENOG4105CPC Aldo Keto reductase LBP_cg0182 ENOG4105F23 Fibronectin-binding protein LBP_cg0183 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) LBP_cg0185 ENOG4106A8V Protein CrcB homolog LBP_cg0188 ENOG4105D5G Transposase LBP_cg0189 ENOG4105C5H ABC transporter LBP_cg0194 ENOG4108JJB ABC transporter LBP_cg0196 ENOG4108V06 Glutathione peroxidase LBP_cg0198 ENOG4105KP9 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) LBP_cg0201 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) LBP_cg0205 ENOG4105DZW Dipeptidase LBP_cg0206 ENOG4105CTS PTS system mannitol-specific LBP_cg0208 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein LBP_cg0209 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase LBP_cg0211 ENOG4105K63 Thioredoxin LBP_cg0217 ENOG4108YYH Nadph-dependent fmn reductase LBP_cg0219 ENOG4105C28 cystathionine LBP_cg0220 ENOG4105C6T cysteine synthase LBP_cg0221 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) LBP_cg0225 ENOG4107414 GntR family transcriptional regulator LBP_cg0226 ENOG4105CG3 alpha amylase, catalytic region LBP_cg0227 ENOG4105C5Y PTS System LBP_cg0228 ENOG4105C5Y PTS System LBP_cg0230 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase LBP_cg0231 ENOG4107SJB teichoic acid biosynthesis LBP_cg0232 ENOG4107SJB teichoic acid biosynthesis LBP_cg0233 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase LBP_cg0234 ENOG41062SP LBP_cg0235 ENOG4108Z40 Transcriptional regulator LBP_cg0236 ENOG4105MKU Transcriptional regulator LBP_cg0237 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) LBP_cg0241 ENOG4105C0R drug resistance transporter emrb qaca subfamily LBP_cg0243 ENOG4105GR3 Histidine kinase LBP_cg0244 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LBP_cg0247 ENOG4105CK1 PTS System LBP_cg0250 ENOG4108KGH TRANSCRIPTIONal LBP_cg0251 ENOG4105CQB FAD linked oxidase domain protein LBP_cg0255 ENOG4105EYF MMPL domain protein LBP_cg0255 ENOG4105EYF MMPL domain protein LBP_cg0256 ENOG4108R3E Dna-3-methyladenine glycosylase i LBP_cg0258 ENOG4107WD8 ABC transporter, permease LBP_cg0262 ENOG4106770 Is able to cleave peptidoglycan (By similarity) LBP_cg0269 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) LBP_cg0272 ENOG4108U05 Transcriptional regulator LBP_cg0273 ENOG4105CEP NADH dehydrogenase LBP_cg0275 ENOG4108HM4 ABC transporter LBP_cg0278 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LBP_cg0284 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family LBP_cg0285 ENOG4105CZV ABC transporter LBP_cg0288 ENOG4108EKI Dehydrogenase LBP_cg0293 ENOG4105DZW Dipeptidase LBP_cg0295 ENOG41080Y5 BioY family LBP_cg0302 ENOG4105EY8 ABC transporter LBP_cg0305 ENOG4105C0R drug resistance transporter emrb qaca subfamily LBP_cg0306 ENOG4105BZU Histidine kinase LBP_cg0312 ENOG4105E66 phosphoriboisomerase A LBP_cg0314 ENOG4105KA3 membrAne LBP_cg0315 ENOG4105KIS phospholipid-binding protein LBP_cg0320 ENOG4105DU0 nucleoside hydrolase LBP_cg0321 ENOG4105E1F short-chain dehydrogenase reductase LBP_cg0324 ENOG4108IJ8 ABC transporter LBP_cg0326 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) LBP_cg0327 ENOG4105C6V Glycerol-3-phosphate dehydrogenase LBP_cg0328 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) LBP_cg0332 ENOG4105D5G Transposase LBP_cg0335 ENOG4108JJA ABC, transporter LBP_cg0342 ENOG4105VDM plasmid maintenance system antidote protein, xre family LBP_cg0343 ENOG4105EEM helicase LBP_cg0344 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase LBP_cg0345 ENOG4105C31 Tryptophanyl-tRNA synthetase LBP_cg0346 ENOG4108S3Y transcriptional regulator LBP_cg0347 ENOG4105CK1 PTS System LBP_cg0357 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) LBP_cg0358 ENOG4105I3N Conserved Protein LBP_cg0362 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) LBP_cg0363 ENOG4105C2C drug resistance transporter, Bcr CflA LBP_cg0367 ENOG4105F8V Hydrolase, tatD family LBP_cg0368 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) LBP_cg0369 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) LBP_cg0370 ENOG4105W42 Veg protein LBP_cg0371 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) LBP_cg0374 ENOG4105FDK ABC transporter LBP_cg0375 ENOG4105CC5 ABC transporter LBP_cg0381 ENOG4105DFT pur operon repressor LBP_cg0382 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) LBP_cg0384 ENOG4105C5T Phosphoribosyl pyrophosphate synthase LBP_cg0387 ENOG4105DQ6 Transposase LBP_cg0390 ENOG4105DCI Phosphohydrolase LBP_cg0391 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) LBP_cg0393 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) LBP_cg0394 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) LBP_cg0395 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) LBP_cg0396 ENOG4105C44 Serine transporter LBP_cg0398 ENOG4105EJQ L-serine dehydratase LBP_cg0401 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) LBP_cg0402 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) LBP_cg0403 ENOG41082DI 50s ribosomal protein l31 LBP_cg0405 ENOG4108Z6X (sortase) family LBP_cg0406 ENOG4108V0P LemA family LBP_cg0407 ENOG4105D0M Protease HtpX homolog LBP_cg0409 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) LBP_cg0410 ENOG4105C1J atp-dependent rna helicase LBP_cg0412 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) LBP_cg0413 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) LBP_cg0414 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) LBP_cg0415 ENOG4105DFH Transport of potassium into the cell (By similarity) LBP_cg0421 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain LBP_cg0422 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase LBP_cg0423 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) LBP_cg0424 ENOG4105CAS nag kinase LBP_cg0425 ENOG4105C8Y Acetylornithine aminotransferase LBP_cg0426 ENOG4105DBV ornithine carbamoyltransferase LBP_cg0430 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) LBP_cg0431 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) LBP_cg0432 ENOG4108JA2 transcriptioN-repair coupling factor LBP_cg0434 ENOG41082I2 s4 domain protein LBP_cg0436 ENOG41060GV RNA binding s1 domain protein LBP_cg0437 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) LBP_cg0440 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) LBP_cg0441 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) LBP_cg0442 ENOG4105CRK lysyL-tRNA synthetase LBP_cg0444 ENOG4105DUX Transporter LBP_cg0451 ENOG4106Z1T Nicotinamide Mononucleotide Transporter LBP_cg0452 ENOG4105II7 pyrroline-5-carboxylate reductase LBP_cg0454 ENOG4105FDP GntR family transcriptional regulator LBP_cg0456 ENOG4105DAP Nicotinate phosphoribosyltransferase LBP_cg0457 ENOG4107RA1 nh(3)-dependent nad( ) synthetase LBP_cg0461 ENOG410906U SprT-like LBP_cg0462 ENOG4105D6E homoserine dehydrogenase LBP_cg0463 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) LBP_cg0466 ENOG4105ETZ PTS System LBP_cg0467 ENOG4105F3R pts system mannose fructose sorbose family iid LBP_cg0469 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family LBP_cg0470 ENOG4108EQA pts system LBP_cg0471 ENOG4108EQA pts system LBP_cg0472 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) LBP_cg0474 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase LBP_cg0476 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) LBP_cg0477 ENOG4108KGH TRANSCRIPTIONal LBP_cg0479 ENOG4108TVT permease LBP_cg0480 ENOG4108K79 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) LBP_cg0482 ENOG4105CTZ aminopeptidase c LBP_cg0483 ENOG4105E66 phosphoriboisomerase A LBP_cg0485 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) LBP_cg0488 ENOG4105CTP PilT protein domain protein LBP_cg0489 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) LBP_cg0490 ENOG4105C8N cysteinyl-tRNA synthetase LBP_cg0491 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) LBP_cg0492 ENOG4105C2N RNA methyltransferase TrmH family group 3 LBP_cg0495 ENOG4107FTN 50S ribosomal protein L33 LBP_cg0497 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) LBP_cg0499 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) LBP_cg0500 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) LBP_cg0501 ENOG4108VZM 50s ribosomal protein L10 LBP_cg0502 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) LBP_cg0506 ENOG4108URH decarboxylase LBP_cg0508 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LBP_cg0509 ENOG41067VN Glutaredoxin LBP_cg0510 ENOG4107Y49 methyltransferase LBP_cg0512 ENOG4105C6E dna polymerase iii LBP_cg0513 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) LBP_cg0514 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) LBP_cg0516 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) LBP_cg0517 ENOG4105X0R protein from nitrogen regulatory protein P-II LBP_cg0518 ENOG4105FA2 dna polymerase iii LBP_cg0519 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) LBP_cg0520 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) LBP_cg0522 ENOG4105CMR udp-glucose 4-epimerase LBP_cg0523 ENOG4107STF Involved in phosphonate degradation (By similarity) LBP_cg0524 ENOG4108KAZ Involved in phosphonate degradation (By similarity) LBP_cg0525 ENOG4105S7S phosphonate abc transporter LBP_cg0527 ENOG4105D5T phosphonate abc transporter LBP_cg0529 ENOG41072GX Peptidase M22 Glycoprotease LBP_cg0530 ENOG41080E2 ribosomal-protein-alanine acetyltransferase LBP_cg0531 ENOG410801F ribosomal-protein-alanine acetyltransferase LBP_cg0532 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) LBP_cg0534 ENOG4105C5H ABC transporter LBP_cg0535 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) LBP_cg0537 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) LBP_cg0538 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) LBP_cg0539 ENOG4105C0X amino acid LBP_cg0540 ENOG4105ESV Glycosyl transferase, family 4 LBP_cg0542 ENOG4105CVA phosphate LBP_cg0543 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein LBP_cg0547 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving LBP_cg0548 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) LBP_cg0550 ENOG4105DPZ Two component transcriptional regulator (Winged helix family LBP_cg0551 ENOG4105BZU Histidine kinase LBP_cg0552 ENOG4105CVA phosphate LBP_cg0553 ENOG4105C8U phosphate abc transporter LBP_cg0554 ENOG4105E2Z phosphate ABC transporter (Permease LBP_cg0555 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) LBP_cg0556 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) LBP_cg0557 ENOG4108UTW Plays a role in the regulation of phosphate uptake LBP_cg0558 ENOG41067S9 phage shock protein C, PspC LBP_cg0559 ENOG41086DT Membrane protein of unknown function LBP_cg0560 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) LBP_cg0561 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) LBP_cg0562 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase LBP_cg0566 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase LBP_cg0567 ENOG4105C3M thioredoxin reductase LBP_cg0568 ENOG4105H67 Protein of unknown function (DUF421) LBP_cg0572 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase LBP_cg0576 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) LBP_cg0577 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) LBP_cg0578 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) LBP_cg0579 ENOG4105CDH Citrulline--aspartate ligase LBP_cg0580 ENOG4105CH7 arginosuccinase LBP_cg0582 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) LBP_cg0584 ENOG4105CIE May be required for sporulation (By similarity) LBP_cg0585 ENOG4107QSI ABC, transporter LBP_cg0586 ENOG4105C5I Dehydrogenase LBP_cg0587 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) LBP_cg0588 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LBP_cg0590 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase LBP_cg0591 ENOG4105BZA Phosphoglycerate kinase LBP_cg0592 ENOG4105CP7 Triose-phosphate isomerase LBP_cg0593 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) LBP_cg0595 ENOG4105CMQ Chloride channel LBP_cg0596 ENOG4105XZU Preprotein translocase, subunit SecG LBP_cg0598 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) LBP_cg0599 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) LBP_cg0601 ENOG4105E5Q amino acid AbC transporter LBP_cg0602 ENOG4105CDA abc transporter atp-binding protein LBP_cg0605 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) LBP_cg0606 ENOG4108IJ2 phosphate acetyltransferase LBP_cg0607 ENOG4105K8N protein family UPF0079, ATPase LBP_cg0609 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) LBP_cg0610 ENOG4105CGK Exodeoxyribonuclease III LBP_cg0611 ENOG4105EP9 oxidoreductase LBP_cg0612 ENOG4105D4A Cell wall formation (By similarity) LBP_cg0613 ENOG4107SUZ Sodium/hydrogen exchanger family LBP_cg0618 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) LBP_cg0619 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) LBP_cg0622 ENOG4108HCJ Hydrolase LBP_cg0624 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) LBP_cg0627 ENOG4108DBC nitroreductase LBP_cg0631 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) LBP_cg0633 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) LBP_cg0636 ENOG4105C0R drug resistance transporter emrb qaca subfamily LBP_cg0637 ENOG4105C9X ppx gppa phosphatase LBP_cg0638 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) LBP_cg0640 ENOG4105KPE licD family LBP_cg0643 ENOG4105C7N Xanthine uracil vitamin C permease LBP_cg0644 ENOG4105C7K acetolactate synthase LBP_cg0645 ENOG4105DTN riboflavin biosynthesis protein ribF LBP_cg0646 ENOG4105C7K acetolactate synthase LBP_cg0649 ENOG4105EXC Acyl-transferase LBP_cg0650 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) LBP_cg0653 ENOG4105CUB amino acid LBP_cg0656 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) LBP_cg0658 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) LBP_cg0659 ENOG4105G5W regulator Fur family LBP_cg0664 ENOG4105CHM Aminotransferase LBP_cg0665 ENOG4105C5I Dehydrogenase LBP_cg0670 ENOG4105CT1 (ABC) transporter LBP_cg0671 ENOG4105EAD ABC transporter LBP_cg0672 ENOG4105DRP amino acid AbC transporter LBP_cg0673 ENOG4105CI1 PTS System LBP_cg0675 ENOG4105C5Y PTS System LBP_cg0676 ENOG410901P UPF0249 protein LBP_cg0677 ENOG4107R7I amino acid LBP_cg0678 ENOG4105K56 Transcriptional regulator LBP_cg0684 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) LBP_cg0686 ENOG4105KPY Small multidrug resistance protein LBP_cg0689 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) LBP_cg0691 ENOG4105RHY Pfam:UPF0157 LBP_cg0692 ENOG4105DQR SNARE associated Golgi LBP_cg0693 ENOG4105EEM helicase LBP_cg0694 ENOG4105EA8 2-Nitropropane dioxygenase LBP_cg0695 ENOG4105CS9 pantothenic acid kinase LBP_cg0696 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) LBP_cg0698 ENOG4106F1P AAA ATPase, central domain protein LBP_cg0706 ENOG4108IMY Transcriptional regulator LBP_cg0707 ENOG4105D5G Transposase LBP_cg0709 ENOG4105KVH Transcriptional regulator LBP_cg0711 ENOG4105DQ6 Transposase LBP_cg0712 ENOG4105FCW Major Facilitator superfamily LBP_cg0717 ENOG4105EXC Acyl-transferase LBP_cg0718 ENOG4107BMA Transglycosylase associated protein LBP_cg0721 ENOG4105VBF alkaline shock protein LBP_cg0730 ENOG4105CD8 aminopeptidase N LBP_cg0731 ENOG4105DZR Type I site-specific deoxyribonuclease LBP_cg0733 ENOG4105DZR Type I site-specific deoxyribonuclease LBP_cg0743 ENOG4105DBI uridine monophosphokinase LBP_cg0747 ENOG4107RSM transcriptional regulator LBP_cg0749 ENOG4107EFR Flavocytochrome c LBP_cg0752 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) LBP_cg0753 ENOG4105C5S asparaginyl-tRNA synthetase LBP_cg0754 ENOG4105CU9 asparagine synthetase A LBP_cg0756 ENOG4105DZW Dipeptidase LBP_cg0759 ENOG4105C9U ATP-dependent DNA helicase RecQ LBP_cg0760 ENOG4105EMS pseudouridine synthase LBP_cg0761 ENOG41082BM Transcriptional regulator, arsr family LBP_cg0771 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) LBP_cg0773 ENOG4105CAQ asparagine synthetase LBP_cg0786 ENOG4105DWK Membrane LBP_cg0788 ENOG4108KGH TRANSCRIPTIONal LBP_cg0792 ENOG41062ES Transcriptional regulator LBP_cg0795 ENOG4108IQI permease LBP_cg0798 ENOG4105ZMH deoxynucleoside kinase LBP_cg0799 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) LBP_cg0801 ENOG4105KEX transcriptional regulator, ctsr LBP_cg0802 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit LBP_cg0803 ENOG41062JF Transcriptional regulator LBP_cg0804 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LBP_cg0805 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LBP_cg0807 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) LBP_cg0808 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) LBP_cg0809 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) LBP_cg0810 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) LBP_cg0811 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) LBP_cg0812 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) LBP_cg0813 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) LBP_cg0814 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity LBP_cg0815 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) LBP_cg0816 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) LBP_cg0817 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) LBP_cg0818 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) LBP_cg0819 ENOG41082SA 50s ribosomal protein l29 LBP_cg0820 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal LBP_cg0821 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) LBP_cg0822 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) LBP_cg0823 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits LBP_cg0824 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) LBP_cg0825 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) LBP_cg0826 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) LBP_cg0827 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) LBP_cg0828 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) LBP_cg0829 ENOG41084KY 50S ribosomal protein L30 LBP_cg0830 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) LBP_cg0831 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) LBP_cg0832 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) LBP_cg0833 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) LBP_cg0834 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits LBP_cg0835 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) LBP_cg0836 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LBP_cg0837 ENOG4108ZT0 50S ribosomal protein l17 LBP_cg0842 ENOG41088B0 Major membrane immunogen LBP_cg0845 ENOG4108JJB ABC transporter LBP_cg0846 ENOG4108JJB ABC transporter LBP_cg0848 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) LBP_cg0849 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) LBP_cg0850 ENOG4108UJD 30S ribosomal protein S9 LBP_cg0855 ENOG4105CV1 Transketolase (EC 2.2.1.1) LBP_cg0856 ENOG4105E2X shikimate dehydrogenase LBP_cg0857 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase LBP_cg0858 ENOG4105D49 3-dehydroquinate synthase LBP_cg0860 ENOG4107QPK )-transporter LBP_cg0861 ENOG4105VG1 fes assembly suf system protein LBP_cg0862 ENOG4107GFK fumarate LBP_cg0863 ENOG4106DSS Tartrate dehydratase subunit alpha LBP_cg0865 ENOG4105ID8 Transcriptional regulator, ARAC family LBP_cg0866 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase LBP_cg0867 ENOG4105DIK (ABC) transporter LBP_cg0868 ENOG4105CC5 ABC transporter LBP_cg0869 ENOG4105DSE periplasmic solute binding protein LBP_cg0871 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) LBP_cg0872 ENOG4107QPK )-transporter LBP_cg0876 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) LBP_cg0880 ENOG4105C9Q fumarate hydratase class II LBP_cg0881 ENOG4107EFR Flavocytochrome c LBP_cg0883 ENOG4105CMU LysR family (Transcriptional regulator LBP_cg0884 ENOG4107ZGM malolactic fermentation system LBP_cg0885 ENOG4105C6K Malic enzyme LBP_cg0887 ENOG4105CUB amino acid LBP_cg0891 ENOG4105C4M (Ubiquinol oxidase) subunit I LBP_cg0892 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii LBP_cg0893 ENOG4108JJ9 ABC, transporter LBP_cg0894 ENOG4108JJ8 (ABC) transporter LBP_cg0902 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj LBP_cg0903 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) LBP_cg0904 ENOG4108U5N UPF0316 protein LBP_cg0905 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit LBP_cg0906 ENOG4105C4R Atp-dependent dna helicase LBP_cg0907 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) LBP_cg0909 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) LBP_cg0910 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) LBP_cg0911 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) LBP_cg0912 ENOG4105CBD Diacylglycerol kinase LBP_cg0913 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) LBP_cg0916 ENOG4105CK1 PTS System LBP_cg0918 ENOG4106KNT transcriptional regulator LBP_cg0921 ENOG4105VEQ Cold shock protein LBP_cg0923 ENOG4105EE0 oxidoreductase LBP_cg0924 ENOG4105FDU atp-dependent rna helicase LBP_cg0926 ENOG4105CK1 PTS System LBP_cg0930 ENOG4107R37 Glutamate dehydrogenase LBP_cg0933 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase LBP_cg0935 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) LBP_cg0944 ENOG410902V Modulates RecA activity (By similarity) LBP_cg0945 ENOG4105EVI UPF0374 protein LBP_cg0946 ENOG4105K4H Nlp p60 protein LBP_cg0950 ENOG4105C02 permease LBP_cg0951 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase LBP_cg0952 ENOG4105C6Z Gluconate LBP_cg0953 ENOG4105CMG Carbohydrate kinase LBP_cg0955 ENOG4105DC8 reductase LBP_cg0956 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) LBP_cg0964 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LBP_cg0965 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LBP_cg0967 ENOG4108JQ7 (ABC) transporter LBP_cg0971 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit LBP_cg0973 ENOG4105KRI phosphocarrier protein (HPr LBP_cg0974 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) LBP_cg0975 ENOG4105BZF Glycosyl transferase (Group 1 LBP_cg0976 ENOG4105W2C Glycosyl transferase LBP_cg0979 ENOG4105CHM Aminotransferase LBP_cg0980 ENOG4107IN1 Protein of unknown function (DUF1797) LBP_cg0981 ENOG4105E0M Sulfatase LBP_cg0983 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) LBP_cg0989 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) LBP_cg0990 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) LBP_cg0991 ENOG4108IQI permease LBP_cg0992 ENOG4107QK5 Homocysteine s-methyltransferase LBP_cg0993 ENOG4105Q84 sucrose synthase LBP_cg0995 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP LBP_cg0996 ENOG4105C0R drug resistance transporter emrb qaca subfamily LBP_cg1006 ENOG4105C8T Leucyl-tRNA synthetase LBP_cg1009 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) LBP_cg1010 ENOG4107QSE Dipeptidase LBP_cg1012 ENOG4108IJ9 (ABC) transporter LBP_cg1013 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component LBP_cg1014 ENOG4105DRS transport system, permease LBP_cg1016 ENOG4105ZMH deoxynucleoside kinase LBP_cg1017 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) LBP_cg1018 ENOG4105ECB domain protein LBP_cg1018 ENOG4105ECB domain protein LBP_cg1022 ENOG4108NEV two component transcriptional regulator, LytTR family LBP_cg1024 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) LBP_cg1026 ENOG4105VUF Transcriptional regulator LBP_cg1028 ENOG4108UZ3 Transporter LBP_cg1029 ENOG410667J hydrolase LBP_cg1032 ENOG4108WCX response regulator LBP_cg1036 ENOG4105K56 Transcriptional regulator LBP_cg1039 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) LBP_cg1046 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) LBP_cg1049 ENOG4107RIQ Sulfate adenylate transferase LBP_cg1050 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) LBP_cg1051 ENOG4105SFS phosphoesterase RecJ domain protein LBP_cg1058 ENOG4107YB6 acetyltransferase, (GNAT) family LBP_cg1059 ENOG4105C75 arginyL-tRNA synthetase LBP_cg1062 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LBP_cg1066 ENOG4105VCP PTS System LBP_cg1067 ENOG4105VZJ PTS System LBP_cg1068 ENOG4105CK1 PTS System LBP_cg1069 ENOG4105CS2 ec 3.2.1.21 LBP_cg1071 ENOG4105S7A ErfK ybiS ycfS ynhG family protein LBP_cg1074 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LBP_cg1076 ENOG4105CHM Aminotransferase LBP_cg1077 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) LBP_cg1079 ENOG4105BZ4 penicillin-binding protein LBP_cg1080 ENOG4105WZB UPF0342 protein LBP_cg1081 ENOG4107VRP DNA repair exonuclease LBP_cg1082 ENOG4106D4I domain protein LBP_cg1083 ENOG4105EQI Metal Dependent Phosphohydrolase LBP_cg1086 ENOG4105C5Q Transcriptional regulator LBP_cg1088 ENOG4107EFR Flavocytochrome c LBP_cg1099 ENOG4108R6K riboflavin synthase, subunit alpha LBP_cg1100 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) LBP_cg1101 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) LBP_cg1104 ENOG4105DS0 Transcriptional regulator, Crp Fnr family LBP_cg1107 ENOG4105D5G Transposase LBP_cg1109 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase LBP_cg1116 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) LBP_cg1118 ENOG4105K59 histidine triad (HIT) protein LBP_cg1121 ENOG4108V15 phosphotransferase enzyme family LBP_cg1122 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) LBP_cg1124 ENOG4108VDD TRNA binding domain protein LBP_cg1126 ENOG4105DFU Cell wall formation (By similarity) LBP_cg1131 ENOG4105JRK feS assembly protein SufD LBP_cg1132 ENOG4105C9B Cysteine desulfurase LBP_cg1133 ENOG4108UNV SUF system FeS assembly protein, NifU family LBP_cg1134 ENOG4105DIW FeS assembly protein SUFB LBP_cg1135 ENOG4105VG1 fes assembly suf system protein LBP_cg1138 ENOG4105C2M dna polymerase I LBP_cg1139 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) LBP_cg1140 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) LBP_cg1141 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) LBP_cg1144 ENOG4105C22 threonyL-tRNA synthetase LBP_cg1145 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) LBP_cg1146 ENOG4105VJV 50s ribosomal protein L35 LBP_cg1147 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) LBP_cg1149 ENOG4105D1H recombination factor protein RarA LBP_cg1150 ENOG4105CIS alcohol dehydrogenase LBP_cg1151 ENOG4105KVH Transcriptional regulator LBP_cg1153 ENOG4105CND Glycosyl transferase, family 2 LBP_cg1156 ENOG4105CQW ribosome biogenesis GTPase YqeH LBP_cg1157 ENOG410812S Rna-binding protein LBP_cg1158 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) LBP_cg1159 ENOG4108WF2 Metal Dependent Phosphohydrolase LBP_cg1160 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) LBP_cg1161 ENOG4105DXX methyltransferase LBP_cg1162 ENOG4105CDE UPF0348 protein LBP_cg1167 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) LBP_cg1168 ENOG4105D1H recombination factor protein RarA LBP_cg1169 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LBP_cg1170 ENOG4105GR3 Histidine kinase LBP_cg1172 ENOG4105EYH Exonuclease LBP_cg1175 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) LBP_cg1176 ENOG410855V Acylphosphatase LBP_cg1177 ENOG4108RWN rrna methyltransferase LBP_cg1180 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) LBP_cg1181 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) LBP_cg1183 ENOG4105DBI uridine monophosphokinase LBP_cg1184 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) LBP_cg1187 ENOG4105W8X HesB YadR YfhF-family protein LBP_cg1189 ENOG4107RF6 penicillin-binding protein LBP_cg1190 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase LBP_cg1191 ENOG4107ZXI Rhomboid family LBP_cg1193 ENOG4105DKQ ROK family LBP_cg1197 ENOG4108QXE glycerophosphoryl diester phosphodiesterase LBP_cg1198 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) LBP_cg1199 ENOG4105KV4 Transcriptional regulator LBP_cg1200 ENOG4105C5F glutamine synthetase LBP_cg1209 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) LBP_cg1211 ENOG4105K46 50S ribosomal protein l27 LBP_cg1212 ENOG4105DC7 peptidase M24 LBP_cg1213 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) LBP_cg1214 ENOG4108ZSR alkaline shock protein LBP_cg1215 ENOG4105M7K Involved in the transcription termination process (By similarity) LBP_cg1216 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) LBP_cg1217 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) LBP_cg1218 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) LBP_cg1219 ENOG4105CTB Polyprenyl synthetase LBP_cg1220 ENOG4105DX0 Hemolysin A LBP_cg1221 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) LBP_cg1222 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) LBP_cg1225 ENOG4108HQR Glycine betaine LBP_cg1226 ENOG4105R40 Glycine betaine carnitine choline LBP_cg1228 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) LBP_cg1229 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) LBP_cg1230 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase LBP_cg1231 ENOG4105C25 Primosomal protein n' LBP_cg1232 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) LBP_cg1233 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B LBP_cg1234 ENOG4108ZF3 Phosphatase LBP_cg1235 ENOG4105D9P serine threonine protein kinase LBP_cg1236 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) LBP_cg1237 ENOG4105DJV ribulose-phosphate 3-epimerase LBP_cg1238 ENOG4105FJ0 thiamine LBP_cg1240 ENOG4105VB9 50S ribosomal protein l28 LBP_cg1241 ENOG4108ZAA Alkaline-shock protein LBP_cg1242 ENOG4105DP4 dak2 domain fusion protein ylov LBP_cg1243 ENOG4105CB5 ATP-dependent DNA helicase recG LBP_cg1244 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) LBP_cg1245 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) LBP_cg1246 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) LBP_cg1247 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) LBP_cg1248 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) LBP_cg1249 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) LBP_cg1250 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY LBP_cg1251 ENOG4105K5M 30s ribosomal protein S16 LBP_cg1252 ENOG4105VB6 UPF0109 protein LBP_cg1253 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) LBP_cg1254 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) LBP_cg1255 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) LBP_cg1263 ENOG4105DDQ anthranilate synthase LBP_cg1264 ENOG4108I0Q anthranilate phosphoribosyltransferase LBP_cg1265 ENOG4105DK0 Indole-3-glycerol phosphate synthase LBP_cg1266 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase LBP_cg1267 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) LBP_cg1268 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) LBP_cg1273 ENOG4105CH2 amidohydrolase LBP_cg1274 ENOG4105CPQ Dehydrogenase LBP_cg1277 ENOG4105E1F short-chain dehydrogenase reductase LBP_cg1279 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) LBP_cg1280 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) LBP_cg1281 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) LBP_cg1282 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase LBP_cg1283 ENOG4105CHR reductase LBP_cg1284 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) LBP_cg1286 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) LBP_cg1287 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase LBP_cg1290 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH LBP_cg1292 ENOG4108UQV Membrane LBP_cg1293 ENOG4105DUM transcriptional regulator, lysR family LBP_cg1294 ENOG4108S4H thioesterase Superfamily protein LBP_cg1295 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) LBP_cg1297 ENOG4105C57 major facilitator superfamily LBP_cg1304 ENOG4108M1A Chitin-binding protein LBP_cg1305 ENOG41067V3 Antibiotic biosynthesis monooxygenase LBP_cg1307 ENOG4105KAV tspo and mbr like protein LBP_cg1309 ENOG4105KAF membrAne LBP_cg1310 ENOG4105CBD Diacylglycerol kinase LBP_cg1313 ENOG4107BMA Transglycosylase associated protein LBP_cg1314 ENOG4106EMP CsbD-like LBP_cg1317 ENOG4105DZW Dipeptidase LBP_cg1318 ENOG41069HH 4-oxalocrotonate tautomerase LBP_cg1326 ENOG4108JPW Aminotransferase LBP_cg1327 ENOG4105CUB amino acid LBP_cg1328 ENOG4108KP7 hydrolase LBP_cg1329 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B LBP_cg1333 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) LBP_cg1334 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) LBP_cg1338 ENOG4105DVT helicase LBP_cg1341 ENOG4105C5S asparaginyl-tRNA synthetase LBP_cg1343 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) LBP_cg1344 ENOG4108UMI ABC transporter, permease LBP_cg1348 ENOG4105D38 putrescine abc transporter LBP_cg1349 ENOG4107QKW extracellular solute-binding protein family 1 LBP_cg1352 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) LBP_cg1353 ENOG4108UKS UPF0398 protein LBP_cg1354 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) LBP_cg1356 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) LBP_cg1360 ENOG4108MXZ Esterase LBP_cg1362 ENOG4107QRS glycosyltransferase group 2 family protein LBP_cg1368 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A LBP_cg1374 ENOG4107VFR oxidoreductase LBP_cg1377 ENOG4105CKU formyltetrahydrofolate synthetase LBP_cg1378 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) LBP_cg1379 ENOG4105C34 Pseudouridine synthase LBP_cg1380 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) LBP_cg1381 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain LBP_cg1382 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain LBP_cg1384 ENOG4108ZMX Domain of unknown function (DU1801) LBP_cg1390 ENOG4105CJ1 ABC, transporter LBP_cg1391 ENOG4108TU7 Inherit from COG: (ABC) transporter LBP_cg1392 ENOG4105F23 Fibronectin-binding protein LBP_cg1394 ENOG4105EPR degv family LBP_cg1407 ENOG4105C85 amino acid LBP_cg1410 ENOG4105DAA L-lactate LBP_cg1412 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) LBP_cg1414 ENOG4107RZX Teichoic acid biosynthesis protein LBP_cg1417 ENOG4105K56 Transcriptional regulator LBP_cg1418 ENOG4107QN2 dihydrolipoyl dehydrogenase LBP_cg1425 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) LBP_cg1426 ENOG4105E0X reductase LBP_cg1427 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase LBP_cg1428 ENOG4105DND Transcriptional regulator LBP_cg1430 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LBP_cg1431 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) LBP_cg1433 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) LBP_cg1434 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) LBP_cg1435 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LBP_cg1436 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) LBP_cg1437 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) LBP_cg1438 ENOG4105C79 DNA protecting protein DprA LBP_cg1439 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) LBP_cg1440 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) LBP_cg1442 ENOG4107RSM transcriptional regulator LBP_cg1448 ENOG4105VSD UPF0346 protein LBP_cg1449 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) LBP_cg1450 ENOG41090WU lipolytic protein G-D-S-L family LBP_cg1451 ENOG4108RCR degv family LBP_cg1452 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) LBP_cg1453 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) LBP_cg1454 ENOG4105C5H ABC transporter LBP_cg1456 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate LBP_cg1457 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) LBP_cg1459 ENOG4108HCJ Hydrolase LBP_cg1460 ENOG41068YB TPR repeat-containing protein LBP_cg1462 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) LBP_cg1463 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) LBP_cg1464 ENOG4105CAT Cytidine monophosphate kinase LBP_cg1466 ENOG4105C9U ATP-dependent DNA helicase RecQ LBP_cg1468 ENOG4108SAX Membrane LBP_cg1469 ENOG4105FE9 pseudouridine synthase LBP_cg1470 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) LBP_cg1471 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) LBP_cg1473 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LBP_cg1474 ENOG4105QNR S1 RNA binding domain protein LBP_cg1476 ENOG4105CA9 Pyruvate kinase LBP_cg1477 ENOG4105CTQ phosphohexokinase LBP_cg1478 ENOG4105C0B DNA polymerase III (alpha subunit) LBP_cg1481 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit LBP_cg1482 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) LBP_cg1483 ENOG4105EGD dinuclear metal center protein, YbgI family LBP_cg1491 ENOG41082F9 transcriptional regulator LBP_cg1496 ENOG4105C59 p-type ATPase LBP_cg1498 ENOG4105C0R drug resistance transporter emrb qaca subfamily LBP_cg1500 ENOG4107PP3 Acetylornithine deacetylase LBP_cg1501 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase LBP_cg1502 ENOG4105E98 transcriptional regulator DeoR family LBP_cg1504 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) LBP_cg1512 ENOG4105DQ6 Transposase LBP_cg1518 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) LBP_cg1524 ENOG4108W5M transcriptional regulator LBP_cg1525 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein LBP_cg1527 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase LBP_cg1528 ENOG4108S01 response regulator LBP_cg1529 ENOG4108ZGX Histidine kinase LBP_cg1531 ENOG4108M15 ABC transporter LBP_cg1533 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) LBP_cg1538 ENOG4105CJ1 ABC, transporter LBP_cg1542 ENOG4105CZV ABC transporter LBP_cg1543 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family LBP_cg1544 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LBP_cg1545 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) LBP_cg1546 ENOG4105C38 Glycyl-tRNA synthetase beta subunit LBP_cg1547 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit LBP_cg1548 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) LBP_cg1549 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) LBP_cg1550 ENOG4107YR5 Diacylglycerol kinase LBP_cg1551 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) LBP_cg1552 ENOG4105C9A Phoh family LBP_cg1554 ENOG4105KTH gatB Yqey LBP_cg1555 ENOG4105VCC 30S ribosomal protein S21 LBP_cg1556 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) LBP_cg1557 ENOG4105CHR reductase LBP_cg1558 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) LBP_cg1560 ENOG4107AYK membrAne LBP_cg1561 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) LBP_cg1562 ENOG4105C9M aspartyl-trna synthetase LBP_cg1563 ENOG4105CUT histidyl-tRNA synthetase LBP_cg1564 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase LBP_cg1566 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) LBP_cg1567 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) LBP_cg1568 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) LBP_cg1570 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) LBP_cg1571 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) LBP_cg1572 ENOG4108VX5 3-methyladenine DNA glycosylase LBP_cg1577 ENOG4105VTR Integrase LBP_cg1578 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) LBP_cg1579 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD LBP_cg1580 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) LBP_cg1581 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein LBP_cg1582 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) LBP_cg1584 ENOG4105FQP Beta-lactamase LBP_cg1585 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) LBP_cg1586 ENOG4105CFG Acts as a chaperone (By similarity) LBP_cg1587 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ LBP_cg1588 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) LBP_cg1589 ENOG4107FQX Alpha-acetolactate decarboxylase LBP_cg1590 ENOG4105DTN riboflavin biosynthesis protein ribF LBP_cg1591 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) LBP_cg1594 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase LBP_cg1596 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase LBP_cg1597 ENOG4105EMV Major Facilitator LBP_cg1598 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) LBP_cg1599 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) LBP_cg1601 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination LBP_cg1602 ENOG4105CHV Transcription elongation factor NusA LBP_cg1603 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) LBP_cg1604 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) LBP_cg1607 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) LBP_cg1608 ENOG4105DZP Membrane-associated zinc metalloprotease LBP_cg1609 ENOG4105KNE Phosphatidate cytidylyltransferase LBP_cg1610 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) LBP_cg1611 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) LBP_cg1612 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) LBP_cg1613 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) LBP_cg1614 ENOG4105CE9 30S ribosomal protein S2 LBP_cg1616 ENOG4105C5I Dehydrogenase LBP_cg1617 ENOG4105VC4 domain protein LBP_cg1618 ENOG41060K3 Methyltransferase LBP_cg1619 ENOG4105F6E Acyl-transferase LBP_cg1620 ENOG4105VXM UPF0154 protein LBP_cg1621 ENOG4105VPS UPF0291 protein LBP_cg1622 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) LBP_cg1624 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase LBP_cg1627 ENOG4105CKK Glycosyl transferase, family 2 LBP_cg1629 ENOG4108KGH TRANSCRIPTIONal LBP_cg1692 ENOG4105K8R UPF0145 protein LBP_cg1695 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) LBP_cg1696 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) LBP_cg1697 ENOG41067VP Protein of unknown function (DUF1049) LBP_cg1698 ENOG4108IXY short-chain dehydrogenase reductase LBP_cg1699 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) LBP_cg1702 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control LBP_cg1703 ENOG4105E98 transcriptional regulator DeoR family LBP_cg1704 ENOG4105DE4 1-phosphofructokinase LBP_cg1705 ENOG4105DM4 PTS System LBP_cg1706 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) LBP_cg1708 ENOG4108RYC glycosyltransferase LBP_cg1712 ENOG4107QPH glycogen) synthase LBP_cg1714 ENOG4108IAJ Nad-dependent epimerase dehydratase LBP_cg1716 ENOG4108QV3 biosynthesis protein LBP_cg1718 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) LBP_cg1719 ENOG4105CDA abc transporter atp-binding protein LBP_cg1720 ENOG4105EAD ABC transporter LBP_cg1724 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) LBP_cg1725 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) LBP_cg1726 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation LBP_cg1727 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) LBP_cg1730 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) LBP_cg1731 ENOG4105C6X Major Facilitator LBP_cg1732 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) LBP_cg1733 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) LBP_cg1734 ENOG4105TQK DNA polymerase iii, delta' subunit LBP_cg1735 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 LBP_cg1736 ENOG4108UK2 deaminase LBP_cg1737 ENOG4105KQC Competence protein LBP_cg1738 ENOG41063PX domain protein LBP_cg1739 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) LBP_cg1740 ENOG4106H78 methyltransferase LBP_cg1741 ENOG4105WUC UPF0298 protein LBP_cg1742 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) LBP_cg1743 ENOG4105CNI cell division protein FtsW LBP_cg1751 ENOG4105CI3 gtp-binding protein typa LBP_cg1752 ENOG4105ECY inositol monophosphatase LBP_cg1753 ENOG4105WBI UPF0223 protein LBP_cg1754 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) LBP_cg1758 ENOG4107RUY (E1 component), alpha subunit LBP_cg1759 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) LBP_cg1761 ENOG4106EHS UPF0356 protein LBP_cg1762 ENOG4105CN5 Metallo-Beta-Lactamase LBP_cg1765 ENOG41069ER domain protein LBP_cg1766 ENOG4105C5T Phosphoribosyl pyrophosphate synthase LBP_cg1767 ENOG4105C7H Helicase, RecD TraA family LBP_cg1769 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) LBP_cg1773 ENOG4107ZYR domain protein LBP_cg1775 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) LBP_cg1777 ENOG4105C3J Cysteine desulfurase LBP_cg1778 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) LBP_cg1780 ENOG4108YZ4 nudix hydrolase LBP_cg1781 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) LBP_cg1782 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) LBP_cg1785 ENOG41067XK integral membrane protein LBP_cg1786 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) LBP_cg1789 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) LBP_cg1790 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) LBP_cg1791 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) LBP_cg1792 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) LBP_cg1793 ENOG4105CJN penicillin-binding protein LBP_cg1795 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) LBP_cg1796 ENOG4108V6E Cell division protein mraZ LBP_cg1800 ENOG4105DQ6 Transposase LBP_cg1802 ENOG4105CNU cell division protein FtsK LBP_cg1803 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) LBP_cg1805 ENOG4105CWM branched-chain amino acid transport system II carrier protein LBP_cg1808 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) LBP_cg1811 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) LBP_cg1812 ENOG4106N3A copper homeostasis protein cutc LBP_cg1813 ENOG4105EMS pseudouridine synthase LBP_cg1814 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) LBP_cg1817 ENOG4105DPN Oligoendopeptidase f LBP_cg1819 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis LBP_cg1820 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) LBP_cg1821 ENOG4108RQ5 Beta-lactamase domain-containing protein LBP_cg1824 ENOG4105DQ6 Transposase LBP_cg1828 ENOG4105DQR SNARE associated Golgi LBP_cg1830 ENOG4105D4U had-superfamily hydrolase, subfamily iia LBP_cg1831 ENOG4105MMD transcriptional regulator LBP_cg1832 ENOG4107R8B 5'-nucleotidase LBP_cg1834 ENOG4105C85 amino acid LBP_cg1835 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) LBP_cg1845 ENOG4105CDY transcriptional regulatory protein LBP_cg1848 ENOG4105ETE Transcriptional regulator (LacI family LBP_cg1849 ENOG4105DC7 peptidase M24 LBP_cg1853 ENOG4105D8X mechanosensitive ion channel LBP_cg1854 ENOG4105CH2 amidohydrolase LBP_cg1855 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) LBP_cg1858 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) LBP_cg1859 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) LBP_cg1861 ENOG4105K63 Thioredoxin LBP_cg1862 ENOG4105C98 muts2 protein LBP_cg1864 ENOG4105VPH UPF0473 protein LBP_cg1865 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) LBP_cg1866 ENOG4105VBH UPF0297 protein LBP_cg1867 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) LBP_cg1868 ENOG4105C1J atp-dependent rna helicase LBP_cg1869 ENOG4105SFS phosphoesterase RecJ domain protein LBP_cg1870 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) LBP_cg1871 ENOG4105VIE preprotein translocase, subunit YajC LBP_cg1872 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) LBP_cg1873 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) LBP_cg1874 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) LBP_cg1875 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) LBP_cg1882 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) LBP_cg1883 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) LBP_cg1884 ENOG4105D48 metallophosphoesterase LBP_cg1885 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) LBP_cg1886 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) LBP_cg1887 ENOG4105CEV competence damage-inducible protein LBP_cg1888 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase LBP_cg1893 ENOG4105CFH Aspartokinase LBP_cg1894 ENOG4108HW3 (ABC) transporter LBP_cg1895 ENOG4105CDA abc transporter atp-binding protein LBP_cg1896 ENOG4105E5Q amino acid AbC transporter LBP_cg1897 ENOG4107QMS site-determining protein LBP_cg1900 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) LBP_cg1901 ENOG4105DFF Rod shape-determining protein mreb LBP_cg1902 ENOG4105W5Q DNA repair protein (RadC LBP_cg1903 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase LBP_cg1904 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) LBP_cg1906 ENOG4105D9M gamma-glutamylcysteine synthetase LBP_cg1907 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) LBP_cg1908 ENOG4105C3J Cysteine desulfurase LBP_cg1910 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) LBP_cg1912 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) LBP_cg1913 ENOG4108WQ8 UPF0637 protein LBP_cg1916 ENOG41085FC arsR family transcriptional regulator LBP_cg1917 ENOG4105D9M gamma-glutamylcysteine synthetase LBP_cg1918 ENOG4105D1H recombination factor protein RarA LBP_cg1920 ENOG4107YZX Universal stress protein LBP_cg1924 ENOG4105CPF Cell wall formation (By similarity) LBP_cg1928 ENOG4105D01 (LipO)protein LBP_cg1929 ENOG4108UMI ABC transporter, permease LBP_cg1930 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) LBP_cg1931 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) LBP_cg1934 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) LBP_cg1935 ENOG4105DFF Rod shape-determining protein mreb LBP_cg1937 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) LBP_cg1938 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) LBP_cg1939 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) LBP_cg1940 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) LBP_cg1941 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) LBP_cg1942 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) LBP_cg1943 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) LBP_cg1944 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) LBP_cg1945 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) LBP_cg1947 ENOG4105D5G Transposase LBP_cg1950 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) LBP_cg1951 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) LBP_cg1952 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) LBP_cg1953 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) LBP_cg1954 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) LBP_cg1955 ENOG4107104 thymidine kinase LBP_cg1956 ENOG4105DMS mur ligase LBP_cg1957 ENOG4105F1K Glutamine amidotransferase LBP_cg1958 ENOG4105DG6 mannose-6-phosphate isomerase LBP_cg1959 ENOG4107S1E Beta-lactamase LBP_cg1961 ENOG4105CM2 brancheD-chain amino acid aminotransferase LBP_cg1964 ENOG4105BZ1 (ABC) transporter LBP_cg1967 ENOG4107BJW polysaccharide deacetylase LBP_cg1994 ENOG4105IG6 Phage terminase, large subunit LBP_cg2018 ENOG4108FPN Integrase LBP_cg2039 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LBP_cg2049 ENOG4105BZ1 (ABC) transporter LBP_cg2052 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LBP_cg2054 ENOG4107QYV phosphohexose isomerase LBP_cg2056 ENOG4105CSC Glucose uptake protein LBP_cg2057 ENOG4105DR4 Methyltransferase LBP_cg2058 ENOG4105BZU Histidine kinase LBP_cg2059 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LBP_cg2060 ENOG4105CAG UPF0210 protein LBP_cg2061 ENOG4105VUC UPF0237 protein LBP_cg2062 ENOG4108UZ3 Transporter LBP_cg2064 ENOG4105DQ6 Transposase LBP_cg2068 ENOG41079KZ Major Facilitator Superfamily LBP_cg2073 ENOG4107SN7 NLP P60 protein LBP_cg2074 ENOG4105EW9 transcriptional regulator AsnC family LBP_cg2077 ENOG4106TD9 Diguanylate cyclase LBP_cg2080 ENOG4105C5H ABC transporter LBP_cg2082 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase LBP_cg2084 ENOG4105CI1 PTS System LBP_cg2085 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) LBP_cg2086 ENOG4105EPR degv family LBP_cg2087 ENOG4105D6E homoserine dehydrogenase LBP_cg2089 ENOG4105CVG Homoserine O-transsuccinylase LBP_cg2092 ENOG4105C7J ABC transporter, permease LBP_cg2094 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase LBP_cg2096 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase LBP_cg2097 ENOG4107TS3 membrane protein, TerC LBP_cg2098 ENOG4108UW5 maltose o-acetyltransferase LBP_cg2099 ENOG4105CIH Imidazole acetol-phosphate transaminase LBP_cg2100 ENOG41083RF phosphoribosyl-ATP pyrophosphatase LBP_cg2101 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase LBP_cg2102 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) LBP_cg2103 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase LBP_cg2104 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) LBP_cg2105 ENOG4105ECC imidazole-glycerol-phosphate dehydratase LBP_cg2106 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) LBP_cg2107 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) LBP_cg2108 ENOG4107Z2D Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) LBP_cg2109 ENOG4108W76 histidinol phosphate phosphatase hisj family LBP_cg2113 ENOG4105VUF Transcriptional regulator LBP_cg2114 ENOG4105E1F short-chain dehydrogenase reductase LBP_cg2116 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) LBP_cg2125 ENOG4105E0M Sulfatase LBP_cg2126 ENOG4108QXE glycerophosphoryl diester phosphodiesterase LBP_cg2127 ENOG4105CAY ferredoxin--nadp reductase LBP_cg2129 ENOG4108M1Z surface protein LBP_cg2130 ENOG4105CSR polyphosphate kinase 2 LBP_cg2131 ENOG4108TVJ Nitroreductase LBP_cg2133 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) LBP_cg2136 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) LBP_cg2137 ENOG4105EE0 oxidoreductase LBP_cg2139 ENOG4105D9R oxidoreductase LBP_cg2140 ENOG4107SUZ Sodium/hydrogen exchanger family LBP_cg2142 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) LBP_cg2147 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family LBP_cg2156 ENOG4105C7K acetolactate synthase LBP_cg2159 ENOG4108MXZ Esterase LBP_cg2161 ENOG4105C28 cystathionine LBP_cg2164 ENOG41081I9 integral membrane protein LBP_cg2168 ENOG4105DF9 Lipoate-protein, ligase LBP_cg2169 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj LBP_cg2170 ENOG4107YZX Universal stress protein LBP_cg2171 ENOG4108YBP pseudouridine synthase LBP_cg2174 ENOG4105CG5 Glycosyl transferase (Group 1 LBP_cg2175 ENOG4107QRI Phosphoketolase LBP_cg2176 ENOG4107UWA esterase LBP_cg2177 ENOG4108TZY GntR Family Transcriptional Regulator LBP_cg2178 ENOG4108Z66 YbaK ebsC protein LBP_cg2186 ENOG4105C37 (CBS) domain LBP_cg2187 ENOG4105MTF NrdI protein LBP_cg2188 ENOG4107SUZ Sodium/hydrogen exchanger family LBP_cg2189 ENOG410605W Major Facilitator LBP_cg2190 ENOG4107TXC Transcriptional regulator LBP_cg2192 ENOG4105CIS alcohol dehydrogenase LBP_cg2194 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase LBP_cg2196 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LBP_cg2197 ENOG4105CHM Aminotransferase LBP_cg2201 ENOG4107ZGM malolactic fermentation system LBP_cg2204 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation LBP_cg2205 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination LBP_cg2207 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) LBP_cg2208 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) LBP_cg2209 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) LBP_cg2210 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain LBP_cg2211 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain LBP_cg2212 ENOG4105CD3 dihydroorotase LBP_cg2213 ENOG4105CXT aspartate transcarbamylase LBP_cg2214 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) LBP_cg2215 ENOG4105G9B Transcriptional regulator LBP_cg2218 ENOG4105C7N Xanthine uracil vitamin C permease LBP_cg2222 ENOG4105CND Glycosyl transferase, family 2 LBP_cg2224 ENOG4105C12 Phosphoribosylglycinamide synthetase LBP_cg2225 ENOG4105DC1 bifunctional purine biosynthesis protein purh LBP_cg2226 ENOG4108V3E phosphoribosylglycinamide formyltransferase LBP_cg2227 ENOG4105CXB phosphoribosylaminoimidazole synthetase LBP_cg2228 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase LBP_cg2229 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii LBP_cg2230 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I LBP_cg2231 ENOG4105VR9 phosphoribosylformylglycinamidine synthase LBP_cg2232 ENOG4105C8V SAICAR synthetase LBP_cg2233 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit LBP_cg2234 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) LBP_cg2235 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) LBP_cg2236 ENOG4107EFR Flavocytochrome c LBP_cg2237 ENOG4105DF9 Lipoate-protein, ligase LBP_cg2238 ENOG4105M2Z protein tyrosine serine phosphatase LBP_cg2241 ENOG4105HDK L-asparaginase LBP_cg2242 ENOG4105C19 ABC transporter LBP_cg2245 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family LBP_cg2246 ENOG4105DVE abc transporter atp-binding protein LBP_cg2248 ENOG4107YZX Universal stress protein LBP_cg2250 ENOG4105WH5 Teichoic acid glycosylation protein LBP_cg2253 ENOG4105C87 Aminotransferase class I and II LBP_cg2257 ENOG4108IUK alpha amylase, catalytic LBP_cg2258 ENOG4105D98 threonine synthase LBP_cg2259 ENOG410667J hydrolase LBP_cg2261 ENOG4108UW5 maltose o-acetyltransferase LBP_cg2262 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) LBP_cg2269 ENOG4105DAP Nicotinate phosphoribosyltransferase LBP_cg2270 ENOG4105MKU Transcriptional regulator LBP_cg2273 ENOG4105BZC d-serine deaminase LBP_cg2274 ENOG4105CS2 ec 3.2.1.21 LBP_cg2275 ENOG4105CS2 ec 3.2.1.21 LBP_cg2276 ENOG4105VCP PTS System LBP_cg2277 ENOG4105VZJ PTS System LBP_cg2278 ENOG4107414 GntR family transcriptional regulator LBP_cg2279 ENOG4105K64 Glycosyl transferase, family 2 LBP_cg2283 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) LBP_cg2284 ENOG4108UZ3 Transporter LBP_cg2288 ENOG4105NQC Flavodoxin LBP_cg2293 ENOG4105FF2 Type I DHQase LBP_cg2294 ENOG4105E5D amino acid LBP_cg2299 ENOG4105PUK Membrane LBP_cg2300 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) LBP_cg2306 ENOG4108UQV Membrane LBP_cg2307 ENOG4108Z5V transcriptional regulator, merr family LBP_cg2310 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) LBP_cg2311 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) LBP_cg2318 ENOG4108IJ0 Aspartate ammonia-lyase LBP_cg2320 ENOG4105EQ0 Major Facilitator superfamily LBP_cg2325 ENOG4105HMI Membrane LBP_cg2326 ENOG4105DUM transcriptional regulator, lysR family LBP_cg2327 ENOG4107XU6 Glycosyl transferase (Group 1 LBP_cg2328 ENOG4105E2K Glycosyl transferase (Group 1 LBP_cg2331 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) LBP_cg2333 ENOG4108IUX (ABC) transporter LBP_cg2335 ENOG4107GJV short-chain dehydrogenase reductase LBP_cg2338 ENOG4105VUF Transcriptional regulator LBP_cg2343 ENOG4105CSM endonuclease III LBP_cg2345 ENOG4105C3F Signal peptidase i LBP_cg2348 ENOG4108W0I acetyltransferase LBP_cg2353 ENOG4108KB2 LysR family Transcriptional regulator LBP_cg2355 ENOG4105CPQ Dehydrogenase LBP_cg2356 ENOG4107EXU Short-chain dehydrogenase reductase Sdr LBP_cg2358 ENOG4107YZX Universal stress protein LBP_cg2359 ENOG4108UW5 maltose o-acetyltransferase LBP_cg2365 ENOG4105D5G Transposase LBP_cg2367 ENOG4105C87 Aminotransferase class I and II LBP_cg2369 ENOG4105CPC Aldo Keto reductase LBP_cg2371 ENOG4105BZ1 (ABC) transporter LBP_cg2372 ENOG4105BZ1 (ABC) transporter LBP_cg2373 ENOG4105C0R drug resistance transporter emrb qaca subfamily LBP_cg2375 ENOG4105ECB domain protein LBP_cg2375 ENOG4105ECB domain protein LBP_cg2377 ENOG4107YCR Transcriptional regulator, ARSR family LBP_cg2378 ENOG4105ZT7 DNA-entry nuclease LBP_cg2383 ENOG4105C5H ABC transporter LBP_cg2384 ENOG4108HCJ Hydrolase LBP_cg2386 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) LBP_cg2389 ENOG4105DEU major facilitator superfamily LBP_cg2396 ENOG4105BZU Histidine kinase LBP_cg2399 ENOG4107XTP (EAL) domain protein LBP_cg2400 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) LBP_cg2401 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase LBP_cg2403 ENOG4107YDN peptide deformylase LBP_cg2411 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) LBP_cg2421 ENOG4108UZ3 Transporter LBP_cg2426 ENOG41066F8 ROK family LBP_cg2429 ENOG4105BZ1 (ABC) transporter LBP_cg2430 ENOG4105BZ1 (ABC) transporter LBP_cg2433 ENOG4108HCJ Hydrolase LBP_cg2434 ENOG4108TVJ Nitroreductase LBP_cg2435 ENOG4105CI1 PTS System LBP_cg2436 ENOG4105E2Y ABC, transporter LBP_cg2437 ENOG4105C7J ABC transporter, permease LBP_cg2445 ENOG4108IV0 ABC, transporter LBP_cg2446 ENOG4105C0Z ABC transporter LBP_cg2447 ENOG4105CF8 branched-chain amino acid ABC transporter, permease LBP_cg2448 ENOG4105C32 Amino acid ABC transporter (Permease) LBP_cg2449 ENOG4105CP9 extracellular ligand-binding receptor LBP_cg2451 ENOG4105F9F transposase LBP_cg2453 ENOG4105WH5 Teichoic acid glycosylation protein LBP_cg2456 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) LBP_cg2460 ENOG4107YCR Transcriptional regulator, ARSR family LBP_cg2462 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LBP_cg2470 ENOG4105VZJ PTS System LBP_cg2471 ENOG4105CK1 PTS System LBP_cg2472 ENOG4105CS2 ec 3.2.1.21 LBP_cg2474 ENOG4105VUF Transcriptional regulator LBP_cg2475 ENOG4106770 Is able to cleave peptidoglycan (By similarity) LBP_cg2479 ENOG4105DSE periplasmic solute binding protein LBP_cg2484 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) LBP_cg2486 ENOG4105BZ1 (ABC) transporter LBP_cg2487 ENOG4105BZ1 (ABC) transporter LBP_cg2490 ENOG4105CYX Short-chain dehydrogenase reductase Sdr LBP_cg2494 ENOG4107SC7 Inner membrane transporter yjeM LBP_cg2498 ENOG4105C59 p-type ATPase LBP_cg2512 ENOG4105CPQ Dehydrogenase LBP_cg2520 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 LBP_cg2521 ENOG4105KVH Transcriptional regulator LBP_cg2522 ENOG4105F27 Major Facilitator LBP_cg2524 ENOG4105CAQ asparagine synthetase LBP_cg2525 ENOG4108WCX response regulator LBP_cg2527 ENOG4107Z3H Transcriptional regulator, TetR family LBP_cg2529 ENOG4105C26 Dehydrogenase LBP_cg2532 ENOG4105KVH Transcriptional regulator LBP_cg2534 ENOG4105DQ6 Transposase LBP_cg2544 ENOG4106KNP GTP-binding protein LepA C-terminus LBP_cg2546 ENOG4105E09 nadh pyrophosphatase LBP_cg2547 ENOG4108KB2 LysR family Transcriptional regulator LBP_cg2548 ENOG4107EFR Flavocytochrome c LBP_cg2552 ENOG4105HUF DNA protection during starvation protein LBP_cg2554 ENOG4105CS2 ec 3.2.1.21 LBP_cg2555 ENOG4105CK1 PTS System LBP_cg2561 ENOG4108V4B ThiJ pfpI LBP_cg2564 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LBP_cg2567 ENOG4105DG4 malate L-lactate dehydrogenase LBP_cg2571 ENOG4105CJ1 ABC, transporter LBP_cg2574 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) LBP_cg2575 ENOG4106F5Q Membrane LBP_cg2578 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase LBP_cg2580 ENOG4105D9P serine threonine protein kinase LBP_cg2591 ENOG4107TCE N-acetyltransferase LBP_cg2598 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) LBP_cg2600 ENOG4105C3G gtp-binding protein LBP_cg2601 ENOG4105VDK protein, conserved in bacteria LBP_cg2602 ENOG4105FA0 parb-like partition protein LBP_cg2603 ENOG4107QJE Chromosome Partitioning Protein LBP_cg2605 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) LBP_cg2611 ENOG4105W8I Transcriptional regulator LBP_cg2612 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LBP_cg2613 ENOG4105EAB amino acid AbC transporter LBP_cg2614 ENOG4105DRP amino acid AbC transporter LBP_cg2615 ENOG4105CDA abc transporter atp-binding protein LBP_cg2616 ENOG4105EAB amino acid AbC transporter LBP_cg2621 ENOG4105C5Y PTS System LBP_cg2622 ENOG4105CG3 alpha amylase, catalytic region LBP_cg2626 ENOG4105C4B ABC transporter, permease LBP_cg2627 ENOG41083J0 (ABC) transporter LBP_cg2628 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) LBP_cg2631 ENOG410667J hydrolase LBP_cg2633 ENOG4105C8I hydrolase, family 38 LBP_cg2634 ENOG4105DM4 PTS System LBP_cg2635 ENOG4108YRF PTS System LBP_cg2636 ENOG4105DM4 PTS System LBP_cg2637 ENOG4105EMD TRANSCRIPTIONal LBP_cg2642 ENOG4105C5Y PTS System LBP_cg2648 ENOG4105G5W regulator Fur family LBP_cg2655 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) LBP_cg2657 ENOG4108RCR degv family LBP_cg2661 ENOG4105EWK phytoene LBP_cg2662 ENOG4105FE1 phytoene synthase LBP_cg2665 ENOG4105BZW Glycerate kinase LBP_cg2666 ENOG4105DC8 reductase LBP_cg2668 ENOG4105C83 adenylosuccinate lyase LBP_cg2669 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis LBP_cg2670 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) LBP_cg2671 ENOG4105M2Z protein tyrosine serine phosphatase LBP_cg2672 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) LBP_cg2676 ENOG4105CUB amino acid LBP_cg2677 ENOG4105DFH Transport of potassium into the cell (By similarity) LBP_cg2679 ENOG4106F5Q Membrane LBP_cg2684 ENOG4108UT2 hemolysin iii LBP_cg2686 ENOG4105PGM cation diffusion facilitator family transporter LBP_cg2690 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) LBP_cg2692 ENOG4105EUJ GTP cyclohydrolase i LBP_cg2697 ENOG4105DSE periplasmic solute binding protein LBP_cg2698 ENOG4105C0R drug resistance transporter emrb qaca subfamily LBP_cg2702 ENOG4107S1E Beta-lactamase LBP_cg2703 ENOG4105C6N Formate acetyltransferase LBP_cg2704 ENOG4105F1A Pyruvate formate-lyase LBP_cg2705 ENOG4105VG1 fes assembly suf system protein LBP_cg2706 ENOG4107RGM aldo keto reductase LBP_cg2713 ENOG4105C94 Transporter LBP_cg2714 ENOG4105C59 p-type ATPase LBP_cg2716 ENOG4105UNS Pfam:DUF419 LBP_cg2718 ENOG4105CPN adenine deaminase LBP_cg2719 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) LBP_cg2721 ENOG4105DFD Na H antiporter LBP_cg2722 ENOG4105C85 amino acid LBP_cg2725 ENOG4108W5N phosphatidylglycerophosphatase a LBP_cg2729 ENOG4105K78 MarR family Transcriptional regulator LBP_cg2731 ENOG4105CEN a g-specific adenine glycosylase LBP_cg2734 ENOG4105VN1 Heat shock protein LBP_cg2739 ENOG4108UZ3 Transporter LBP_cg2742 ENOG4107QHE Choloylglycine hydrolase LBP_cg2744 ENOG4105NA0 Transcriptional regulator LBP_cg2747 ENOG4105C0R drug resistance transporter emrb qaca subfamily LBP_cg2758 ENOG4105CGH 5'-nucleotidase LBP_cg2764 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) LBP_cg2765 ENOG4108UVJ appr-1-p processing domain protein LBP_cg2775 ENOG41075H3 AraC family transcriptional regulator LBP_cg2780 ENOG4105CVK Glutamate decarboxylase LBP_cg2788 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) LBP_cg2791 ENOG4105C59 p-type ATPase LBP_cg2792 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) LBP_cg2798 ENOG4105IJJ transcriptional regulator, crp fnr family LBP_cg2799 ENOG4105C9K Endothelin-converting enzyme 1 LBP_cg2803 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase LBP_cg2813 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) LBP_cg2816 ENOG4105CWM branched-chain amino acid transport system II carrier protein LBP_cg2818 ENOG4107UWP Major facilitator superfamily MFS_1 LBP_cg2822 ENOG4105MZU cell filamentation protein LBP_cg2825 ENOG4105W08 virulence gene repressor rsal LBP_cg2826 ENOG4105CQ4 Transcriptional regulator LBP_cg2827 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase LBP_cg2828 ENOG4105CMR udp-glucose 4-epimerase LBP_cg2829 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) LBP_cg2832 ENOG4105DME alpha-galactosidase LBP_cg2833 ENOG4107RBJ symporter LBP_cg2834 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) LBP_cg2835 ENOG4105CQ4 Transcriptional regulator LBP_cg2836 ENOG4105CPC Aldo Keto reductase LBP_cg2840 ENOG4105FF2 Type I DHQase LBP_cg2841 ENOG4105EMV Major Facilitator LBP_cg2842 ENOG4105E2X shikimate dehydrogenase LBP_cg2843 ENOG4105C5Q Transcriptional regulator LBP_cg2844 ENOG4105EMV Major Facilitator LBP_cg2846 ENOG41088PD hydrolase LBP_cg2847 ENOG4108X79 transcriptional regulator LBP_cg2848 ENOG4105CK1 PTS System LBP_cg2849 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate LBP_cg2850 ENOG4105RD7 BadF BadG BcrA BcrD LBP_cg2852 ENOG4105CS2 ec 3.2.1.21 LBP_cg2854 ENOG4105CID antiterminator LBP_cg2855 ENOG4105CS2 ec 3.2.1.21 LBP_cg2856 ENOG4105CS2 ec 3.2.1.21 LBP_cg2857 ENOG4105C5Y PTS System LBP_cg2860 ENOG4105ETE Transcriptional regulator (LacI family LBP_cg2864 ENOG4107QHE Choloylglycine hydrolase LBP_cg2865 ENOG4105D5G Transposase LBP_cg2866 ENOG4107QHE Choloylglycine hydrolase LBP_cg2869 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) LBP_cg2873 ENOG4105ETD TRANSCRIPTIONal LBP_cg2876 ENOG4105DT3 PTS system, galactitol-specific IIc component LBP_cg2877 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) LBP_cg2879 ENOG4105E98 transcriptional regulator DeoR family LBP_cg2880 ENOG4107QRI Phosphoketolase LBP_cg2881 ENOG4105QEK Transcriptional regulator LBP_cg2886 ENOG4107RJ1 sodium solute LBP_cg2890 ENOG4107SCR N-acetylneuraminate lyase LBP_cg2891 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) LBP_cg2895 ENOG4105DQ6 Transposase LBP_cg2899 ENOG4107BMA Transglycosylase associated protein LBP_cg2900 ENOG4105CH6 catalase LBP_cg2901 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) LBP_cg2902 ENOG4108WCX response regulator LBP_cg2904 ENOG410695V Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP (By similarity) LBP_cg2909 ENOG4105C7K acetolactate synthase LBP_cg2910 ENOG4108Z40 Transcriptional regulator LBP_cg2911 ENOG4105C7K acetolactate synthase LBP_cg2913 ENOG4105DZY Pts system, glucitol sorbitol-specific LBP_cg2914 ENOG410787A Pts system, glucitol sorbitol-specific LBP_cg2917 ENOG4105CHR reductase LBP_cg2918 ENOG4105EV1 Ribose uptake protein RbsU LBP_cg2919 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) LBP_cg2921 ENOG4105ETE Transcriptional regulator (LacI family LBP_cg2927 ENOG4108EKI Dehydrogenase LBP_cg2929 ENOG4105U3E Transcriptional regulator LBP_cg2930 ENOG4105PY6 Phenolic acid decarboxylase LBP_cg2932 ENOG4105PY6 Phenolic acid decarboxylase LBP_cg2939 ENOG4105C3F Signal peptidase i LBP_cg2944 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) LBP_cg2945 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) LBP_cg2948 ENOG4107QSI ABC, transporter LBP_cg2950 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins LBP_cg2952 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) LBP_p1g003 ENOG4105C0R drug resistance transporter emrb qaca subfamily LBP_p1g006 ENOG4105CSC Glucose uptake protein LBP_p1g007 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein LBP_p1g011 ENOG4105C5F glutamine synthetase LBP_p1g012 ENOG4105C5F glutamine synthetase LBP_p1g018 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) LBP_p1g021 ENOG4107TS3 membrane protein, TerC LBP_p1g025 ENOG4105C0R drug resistance transporter emrb qaca subfamily LBP_p1g031 ENOG4105DQ6 Transposase LBP_p1g033 ENOG4107QJE Chromosome Partitioning Protein LBP_p1g036 ENOG4105C85 amino acid LBP_p1g043 ENOG4105C9U ATP-dependent DNA helicase RecQ LBP_p1g046 ENOG4105CF7 AraC family transcriptional regulator LBP_p1g047 ENOG4107RBJ symporter LBP_p2g002 ENOG4105CS2 ec 3.2.1.21 LBP_p2g003 ENOG4105DME alpha-galactosidase LBP_p2g006 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) LBP_p2g007 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) LBP_p2g010 ENOG4107RBJ symporter LBP_p2g011 ENOG4105CWM branched-chain amino acid transport system II carrier protein LBP_p2g019 ENOG41067QW Transcriptional regulator LBP_p2g021 ENOG4105D5G Transposase LBP_p2g025 ENOG4105EPR degv family LBP_p2g028 ENOG4105EEX Two component transcriptional regulator (Winged helix family LBP_p2g029 ENOG4105DFH Transport of potassium into the cell (By similarity) LBP_p2g030 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes LBP_p2g033 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) LBP_p2g040 ENOG4107QJE Chromosome Partitioning Protein LBP_p2g050 ENOG4107QN2 dihydrolipoyl dehydrogenase LBP_p3g004 ENOG4107QPK )-transporter LBP_p3g006 ENOG4105D5G Transposase LBP_p3g009 ENOG4107BMA Transglycosylase associated protein LBP_p3g011 ENOG41068KG domain protein LBP_p3g017 ENOG4105E5H Transposase LBP_p3g018 ENOG4105C2W permease LBP_p3g031 ENOG4105C9U ATP-dependent DNA helicase RecQ LBP_p3g039 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) LBP_p4g005 ENOG4105D5G Transposase LBP_p4g006 ENOG4105F9F transposase LBP_p4g008 ENOG41090UD (LipO)protein LBP_p4g012 ENOG4105VDH Dihydroxyacetone kinase LBP_p4g013 ENOG4108UTZ Dihydroxyacetone kinase LBP_p4g014 ENOG4105CMT Dihydroxyacetone kinase LBP_p4g018 ENOG4107QJE Chromosome Partitioning Protein LBP_p4g024 ENOG4105C9U ATP-dependent DNA helicase RecQ LBP_p4g029 ENOG4105DZR Type I site-specific deoxyribonuclease LBP_p4g034 ENOG4105NA0 Transcriptional regulator LBP_p6g011 ENOG4105HUF DNA protection during starvation protein LBP_p7g002 ENOG4105E5Q amino acid AbC transporter LBP_p7g003 ENOG4108HW4 amino acid AbC transporter LBP_p7g004 ENOG4105CDA abc transporter atp-binding protein LBP_p7g014 ENOG4105VEQ Cold shock protein