locus-tag	class	description
A4G16_00005	COG1254	Belongs to the acylphosphatase family
A4G16_00010	COG0308	aminopeptidase N
A4G16_00020	COG0500	methyltransferase
A4G16_00025	COG2830	Protein of unknown function (DUF452)
A4G16_00035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4G16_00040	COG0748	coenzyme F420 binding
A4G16_00045	COG1629	transport
A4G16_00045	COG4771	TonB-dependent receptor
A4G16_00055	COG0814	amino acid
A4G16_00060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4G16_00075	COG1395	domain, Protein
A4G16_00080	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4G16_00115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4G16_00120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4G16_00125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4G16_00130	COG1121	(ABC) transporter
A4G16_00160	COG3063	Type IV pilus biogenesis stability protein PilW
A4G16_00165	COG2183	response to ionizing radiation
A4G16_00170	COG0300	oxidoreductase activity
A4G16_00175	COG0778	Nitroreductase
A4G16_00180	COG0616	signal peptide processing
A4G16_00200	COG0477	Major facilitator Superfamily
A4G16_00220	COG3978	acetolactate synthase activity
A4G16_00235	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A4G16_00240	COG0437	4 iron, 4 sulfur cluster binding
A4G16_00245	COG3301	Polysulphide reductase, NrfD
A4G16_00250	COG1138	Cytochrome C-type biogenesis protein
A4G16_00255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4G16_00260	COG3088	subunit of a heme lyase
A4G16_00260	COG4235	cytochrome complex assembly
A4G16_00265	COG3088	subunit of a heme lyase
A4G16_00265	COG4235	cytochrome complex assembly
A4G16_00270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4G16_00275	COG1127	ABC transporter
A4G16_00280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4G16_00285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4G16_00290	COG2854	intermembrane phospholipid transfer
A4G16_00300	COG5007	Belongs to the BolA IbaG family
A4G16_00305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4G16_00310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A4G16_00320	COG0217	transcriptional regulatory protein
A4G16_00325	COG0494	nUDIX hydrolase
A4G16_00335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G16_00340	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A4G16_00370	COG2431	L-lysine efflux transmembrane transporter activity
A4G16_00380	COG0501	Belongs to the peptidase M48B family
A4G16_00385	COG1238	metal cluster binding
A4G16_00390	COG2116	formate transmembrane transporter activity
A4G16_00395	COG1882	Formate acetyltransferase
A4G16_00410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4G16_00415	COG0339	signal peptide processing
A4G16_00420	COG2831	hemolysin activation secretion protein
A4G16_00480	COG1605	Chorismate mutase
A4G16_00480	COG0077	Prephenate dehydratase
A4G16_00485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4G16_00485	COG0475	glutathione-regulated potassium exporter activity
A4G16_00495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4G16_00500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4G16_00505	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4G16_00510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4G16_00520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4G16_00525	COG1966	Carbon starvation protein
A4G16_00530	COG0084	hydrolase, TatD family'
A4G16_00540	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A4G16_00560	COG3118	belongs to the thioredoxin family
A4G16_00565	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A4G16_00565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G16_00565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4G16_00570	COG1461	Dihydroxyacetone kinase
A4G16_00575	COG2376	Dihydroxyacetone kinase
A4G16_00580	COG0492	ferredoxin-NADP+ reductase activity
A4G16_00585	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A4G16_00600	COG1663	tetraacyldisaccharide 4'-kinase activity
A4G16_00605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4G16_00610	COG0740	serine-type endopeptidase activity
A4G16_00615	COG2166	iron-sulfur cluster assembly
A4G16_00635	COG1942	4-Oxalocrotonate Tautomerase
A4G16_00640	COG0512	Glutamine amidotransferase of anthranilate synthase
A4G16_00645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4G16_00650	COG0009	L-threonylcarbamoyladenylate synthase
A4G16_00655	COG1187	pseudouridine synthase activity
A4G16_00660	COG0471	metal ion transport
A4G16_00660	COG3273	potassium ion transport
A4G16_00665	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4G16_00670	COG1136	(ABC) transporter
A4G16_00675	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4G16_00705	COG0512	Glutamine amidotransferase of anthranilate synthase
A4G16_00710	COG1322	Protein conserved in bacteria
A4G16_00720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4G16_00730	COG2137	regulation of response to DNA damage stimulus
A4G16_00740	COG0551	DNA topoisomerase type I activity
A4G16_00745	COG0009	L-threonylcarbamoyladenylate synthase
A4G16_00750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4G16_00775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4G16_00790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G16_00800	COG4206	TonB-dependent receptor
A4G16_00805	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4G16_00820	COG3115	cell septum assembly
A4G16_00885	COG3620	sequence-specific DNA binding
A4G16_00905	COG1640	4-alpha-glucanotransferase
A4G16_00925	COG0359	binds to the 23S rRNA
A4G16_00930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4G16_00935	COG3842	ATPase activity
A4G16_00945	COG1840	ABC-type Fe3 transport system, periplasmic component
A4G16_00950	COG0488	(ABC) transporter
A4G16_00955	COG4657	Part of a membrane complex involved in electron transport
A4G16_00960	COG2878	Part of a membrane complex involved in electron transport
A4G16_00965	COG4656	Part of a membrane complex involved in electron transport
A4G16_00970	COG2860	membrane
A4G16_00975	COG4658	electron transport chain
A4G16_00990	COG1560	Kdo2-lipid A biosynthetic process
A4G16_00995	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4G16_01000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A4G16_01005	COG0194	GDP metabolic process
A4G16_01010	COG1538	Outer membrane efflux protein
A4G16_01015	COG0402	S-adenosylhomocysteine deaminase activity
A4G16_01020	COG4143	(ABC) transporter
A4G16_01030	COG0617	tRNA 3'-terminal CCA addition
A4G16_01035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4G16_01055	COG0346	lactoylglutathione lyase activity
A4G16_01060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4G16_01065	COG0814	amino acid
A4G16_01070	COG1760	l-serine dehydratase
A4G16_01080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4G16_01085	COG2062	phosphohistidine phosphatase, SixA
A4G16_01090	COG0469	pyruvate kinase activity
A4G16_01095	COG0859	PFAM glycosyl transferase family 9
A4G16_01100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4G16_01105	COG0287	Prephenate dehydrogenase
A4G16_01105	COG1605	Chorismate mutase
A4G16_01115	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4G16_01120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4G16_01125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A4G16_01130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4G16_01140	COG0251	oxidation-reduction process
A4G16_01145	COG3101	peptidyl-lysine hydroxylation
A4G16_01150	COG4232	protein-disulfide reductase activity
A4G16_01155	COG1126	abc transporter atp-binding protein
A4G16_01160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4G16_01165	COG4215	(ABC) transporter
A4G16_01170	COG4160	amino acid transport
A4G16_01175	COG1177	transmembrane transport
A4G16_01180	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4G16_01185	COG3842	ATPase activity
A4G16_01190	COG0210	DNA helicase
A4G16_01195	COG1027	Aspartate ammonia-lyase
A4G16_01200	COG3326	Membrane
A4G16_01205	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4G16_01215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4G16_01220	COG3099	Belongs to the UPF0263 family
A4G16_01225	COG0742	ribosomal rna small subunit methyltransferase
A4G16_01230	COG0552	protein localization to endoplasmic reticulum
A4G16_01235	COG2884	Cell division ATP-binding protein ftsE
A4G16_01240	COG2177	Part of the ABC transporter FtsEX involved in
A4G16_01245	COG0583	DNA-binding transcription factor activity
A4G16_01250	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A4G16_01260	COG2089	acid synthase
A4G16_01275	COG2244	polysaccharide biosynthetic process
A4G16_01285	COG3306	glycosyltransferase involved in LPS biosynthesis
A4G16_01295	COG1216	Glycosyl transferase, family 2
A4G16_01300	COG1216	Glycosyl transferase, family 2
A4G16_01310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4G16_01320	COG0813	purine-nucleoside phosphorylase activity
A4G16_01325	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4G16_01335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4G16_01340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A4G16_01345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4G16_01350	COG0083	homoserine kinase activity
A4G16_01355	COG0527	aspartate kinase activity
A4G16_01355	COG0460	homoserine dehydrogenase
A4G16_01360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4G16_01390	COG1349	DNA-binding transcription factor activity
A4G16_01395	COG2222	sugar isomerase
A4G16_01400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G16_01410	COG3716	PTS system mannose fructose sorbose family IID component
A4G16_01430	COG3684	Belongs to the aldolase LacD family
A4G16_01435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4G16_01440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4G16_01475	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A4G16_01480	COG0594	ribonuclease P activity
A4G16_01495	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A4G16_01520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4G16_01525	COG1088	dTDP-glucose 4,6-dehydratase activity
A4G16_01530	COG3307	-O-antigen
A4G16_01545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4G16_01555	COG1575	Belongs to the MenA family. Type 1 subfamily
A4G16_01560	COG1720	tRNA m6t6A37 methyltransferase activity
A4G16_01570	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4G16_01575	COG1047	Peptidyl-prolyl cis-trans
A4G16_01585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4G16_01590	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A4G16_01595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4G16_01605	COG0745	RESPONSE REGULATOR receiver
A4G16_01610	COG2129	metallophosphoesterase
A4G16_01615	COG3172	ATPase kinase involved in NAD metabolism
A4G16_01620	COG0196	riboflavin kinase activity
A4G16_01625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4G16_01640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4G16_01645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4G16_01650	COG4172	Belongs to the ABC transporter superfamily
A4G16_01655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4G16_01660	COG0601	transmembrane transport
A4G16_01665	COG0747	negative chemotaxis
A4G16_01685	COG1686	Belongs to the peptidase S11 family
A4G16_01700	COG1620	l-lactate permease
A4G16_01705	COG0247	lactate metabolic process
A4G16_01710	COG1139	Iron-sulfur cluster binding protein
A4G16_01715	COG1556	Lactate utilization protein
A4G16_01725	COG1561	YicC-like family, N-terminal region
A4G16_01730	COG0354	folic acid binding
A4G16_01735	COG1869	D-ribose catabolic process
A4G16_01745	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4G16_01750	COG1879	ABC-type sugar transport system periplasmic component
A4G16_01755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G16_01760	COG1609	Transcriptional regulator
A4G16_01765	COG2197	response regulator
A4G16_01775	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A4G16_01785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4G16_01825	COG0084	hydrolase, TatD family'
A4G16_01835	COG4667	esterase of the alpha-beta hydrolase superfamily
A4G16_01845	COG3719	Belongs to the RNase T2 family
A4G16_01855	COG1252	NADH dehydrogenase
A4G16_01860	COG1840	ABC-type Fe3 transport system, periplasmic component
A4G16_01865	COG2252	PERMEase
A4G16_01870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4G16_01875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4G16_01880	COG1862	Preprotein translocase
A4G16_01885	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A4G16_01890	COG2017	converts alpha-aldose to the beta-anomer
A4G16_01900	COG1085	galactose-1-phosphate uridylyltransferase
A4G16_01905	COG1408	metallophosphoesterase
A4G16_01920	COG0709	Synthesizes selenophosphate from selenide and ATP
A4G16_01930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4G16_01935	COG3642	lipopolysaccharide core region biosynthetic process
A4G16_01940	COG0302	gtp cyclohydrolase
A4G16_01950	COG0187	DNA topoisomerase II activity
A4G16_01955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A4G16_01960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4G16_01965	COG0295	cytidine deaminase activity
A4G16_01970	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4G16_01975	COG0542	response to heat
A4G16_01980	COG2259	Doxx family
A4G16_01990	COG3220	belongs to the UPF0276 family
A4G16_01995	COG3219	Protein conserved in bacteria
A4G16_02000	COG1595	DNA-templated transcription, initiation
A4G16_02010	COG3047	cAMP biosynthetic process
A4G16_02020	COG1263	PTS System
A4G16_02020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G16_02020	COG2190	(PTS) system
A4G16_02040	COG2914	Belongs to the UPF0125 (RnfH) family
A4G16_02045	COG2867	negative regulation of translational initiation
A4G16_02050	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A4G16_02055	COG4149	molybdate abc transporter
A4G16_02060	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4G16_02065	COG0842	Transport permease protein
A4G16_02070	COG1131	(ABC) transporter
A4G16_02075	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4G16_02080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4G16_02085	COG2920	part of a sulfur-relay system
A4G16_02090	COG0670	Belongs to the BI1 family
A4G16_02095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4G16_02130	COG0330	HflC and HflK could
A4G16_02135	COG0330	HflC and HflK could
A4G16_02145	COG2610	gluconate transmembrane transporter activity
A4G16_02150	COG1028	Short-chain dehydrogenase reductase Sdr
A4G16_02155	COG0183	Belongs to the thiolase family
A4G16_02160	COG2031	fatty acid transporter
A4G16_02165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A4G16_02170	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4G16_02175	COG0583	DNA-binding transcription factor activity
A4G16_02290	COG4626	Terminase
A4G16_02290	COG1802	Transcriptional regulator
A4G16_02355	COG1403	HNH endonuclease
A4G16_02370	COG4197	protein conserved in bacteria, prophage-related
A4G16_02390	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4G16_02395	COG3657	addiction module killer protein
A4G16_02415	COG0629	single-stranded DNA binding
A4G16_02440	COG0582	viral genome integration into host DNA
A4G16_02455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4G16_02475	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4G16_02480	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A4G16_02620	COG4373	Mu-like prophage FluMu protein gp28
A4G16_02655	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4G16_02710	COG3409	Peptidoglycan-binding domain 1 protein
A4G16_02710	COG3267	Type II secretory pathway component ExeA
A4G16_02735	COG4382	Mu-like prophage protein Gp16
A4G16_02745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4G16_02745	COG0301	tRNA thio-modification
A4G16_02750	COG1629	transport
A4G16_02750	COG4771	TonB-dependent receptor
A4G16_02755	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4G16_02760	COG1560	Kdo2-lipid A biosynthetic process
A4G16_02765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4G16_02775	COG2095	MarC family integral membrane protein
A4G16_02780	COG0303	'Molybdopterin
A4G16_02785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4G16_02795	COG3092	negative regulation of chromosome organization
A4G16_02805	COG2917	probably involved in intracellular septation
A4G16_02810	COG1607	acyl-coa hydrolase
A4G16_02815	COG2350	Protein conserved in bacteria
A4G16_02840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4G16_02845	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A4G16_02850	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A4G16_02870	COG1704	LemA family
A4G16_02875	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4G16_02875	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4G16_02875	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A4G16_02880	COG1105	Belongs to the carbohydrate kinase PfkB family
A4G16_02885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G16_02885	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G16_02890	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A4G16_02895	COG1523	belongs to the glycosyl hydrolase 13 family
A4G16_02910	COG0058	SHG alpha-glucan phosphorylase activity
A4G16_02915	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A4G16_02920	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A4G16_02925	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A4G16_02930	COG5487	UPF0391 membrane protein
A4G16_02935	COG0717	Belongs to the dCTP deaminase family
A4G16_02940	COG0572	uridine kinase
A4G16_02950	COG1077	Cell shape determining protein MreB Mrl
A4G16_02955	COG1792	Involved in formation and maintenance of cell shape
A4G16_02960	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A4G16_02965	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4G16_02970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4G16_02975	COG0121	glutamine amidotransferase
A4G16_02980	COG4774	siderophore transport
A4G16_02985	COG4178	(ABC) transporter
A4G16_02990	COG0142	geranyltranstransferase activity
A4G16_02995	COG1722	exodeoxyribonuclease VII activity
A4G16_03000	COG0633	Ferredoxin
A4G16_03000	COG3217	Mosc domain protein beta barrel domain protein
A4G16_03005	COG1368	sulfuric ester hydrolase activity
A4G16_03015	COG0671	phosphoesterase, PA-phosphatase related
A4G16_03020	COG1534	Rna-binding protein
A4G16_03025	COG0463	Glycosyl transferase, family 2
A4G16_03030	COG0859	PFAM glycosyl transferase family 9
A4G16_03040	COG0328	RNA-DNA hybrid ribonuclease activity
A4G16_03045	COG1286	toxin biosynthetic process
A4G16_03060	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A4G16_03085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4G16_03090	COG1953	Uracil, thiamine, allantoin
A4G16_03100	COG3257	ureidoglycine aminohydrolase activity
A4G16_03105	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4G16_03110	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4G16_03115	COG0549	Belongs to the carbamate kinase family
A4G16_03120	COG1620	l-lactate permease
A4G16_03130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4G16_03135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4G16_03145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A4G16_03150	COG2207	Transcriptional regulator
A4G16_03160	COG1764	response to oxidative stress
A4G16_03165	COG1473	amidohydrolase
A4G16_03170	COG3069	C4-dicarboxylate transmembrane transporter activity
A4G16_03175	COG3340	Belongs to the peptidase S51 family
A4G16_03180	COG0004	ammonium transporteR
A4G16_03190	COG0604	alcohol dehydrogenase
A4G16_03205	COG0481	GTPase activity
A4G16_03210	COG0681	Belongs to the peptidase S26 family
A4G16_03220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4G16_03275	COG4964	Belongs to the GSP D family
A4G16_03300	COG0513	Belongs to the DEAD box helicase family
A4G16_03310	COG0433	COG0433 Predicted ATPase
A4G16_03325	COG2194	sulfuric ester hydrolase activity
A4G16_03330	COG0528	UMP kinase activity
A4G16_03335	COG0233	cytoplasmic translational termination
A4G16_03345	COG4942	peptidase
A4G16_03350	COG2861	carbohydrate metabolic process
A4G16_03355	COG0729	surface antigen
A4G16_03360	COG2911	Protein conserved in bacteria
A4G16_03365	COG4988	ABC transporter
A4G16_03370	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A4G16_03375	COG2915	High frequency lysogenization protein hflD homolog
A4G16_03380	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4G16_03385	COG1349	DNA-binding transcription factor activity
A4G16_03390	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A4G16_03395	COG0187	DNA topoisomerase II activity
A4G16_03400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4G16_03410	COG0561	phosphatase activity
A4G16_03415	COG3850	Histidine kinase
A4G16_03425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4G16_03430	COG0393	Putative heavy-metal-binding
A4G16_03440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4G16_03445	COG3283	Transcriptional regulator of aromatic amino acids metabolism
A4G16_03450	COG4166	transmembrane transport
A4G16_03455	COG4168	peptide transport system, permease
A4G16_03460	COG4171	peptide transport system, permease
A4G16_03465	COG4172	Belongs to the ABC transporter superfamily
A4G16_03470	COG5645	(Lipo)protein
A4G16_03485	COG3021	interspecies interaction between organisms
A4G16_03495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4G16_03545	COG4626	Terminase
A4G16_03545	COG1802	Transcriptional regulator
A4G16_03610	COG0582	viral genome integration into host DNA
A4G16_03630	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A4G16_03640	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A4G16_03640	COG3264	Mechanosensitive ion channel
A4G16_03645	COG0318	PFAM AMP-dependent synthetase and ligase
A4G16_03655	COG0596	Alpha beta hydrolase
A4G16_03660	COG2226	methyltransferase
A4G16_03670	COG0586	Pfam SNARE associated Golgi protein
A4G16_03680	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4G16_03690	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4G16_03700	COG0589	response to stress
A4G16_03710	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A4G16_03715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4G16_03730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4G16_03745	COG1530	ribonuclease E activity
A4G16_03750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4G16_03755	COG3384	dioxygenase
A4G16_03760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4G16_03765	COG2949	membrane
A4G16_03770	COG0788	formyltetrahydrofolate deformylase activity
A4G16_03780	COG1757	Na H antiporter
A4G16_03785	COG4221	oxidoreductase activity
A4G16_03805	COG5339	Protein conserved in bacteria
A4G16_03810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4G16_03810	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4G16_03815	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A4G16_03825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4G16_03830	COG0189	ligase activity
A4G16_03835	COG0281	malic enzyme
A4G16_03835	COG0280	phosphate acetyltransferase
A4G16_03845	COG0629	single-stranded DNA binding
A4G16_03850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4G16_03855	COG0659	secondary active sulfate transmembrane transporter activity
A4G16_03870	COG1199	ATP-dependent helicase activity
A4G16_03875	COG1132	(ABC) transporter
A4G16_03885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4G16_03890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4G16_03895	COG0167	dihydroorotate dehydrogenase activity
A4G16_03900	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A4G16_03905	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4G16_03910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4G16_03915	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4G16_03930	COG3105	Protein conserved in bacteria
A4G16_03935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4G16_03940	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4G16_03945	COG3083	sulfuric ester hydrolase activity
A4G16_03955	COG1309	transcriptional regulator
A4G16_03960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4G16_03975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4G16_03990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4G16_03995	COG0387	Pfam Sodium calcium exchanger
A4G16_04000	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A4G16_04005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4G16_04015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4G16_04020	COG4991	sh3 domain protein
A4G16_04025	COG0306	phosphate transporter
A4G16_04030	COG1392	Phosphate transport regulator
A4G16_04035	COG4604	ABC transporter, ATP-binding protein
A4G16_04040	COG4605	iron ion homeostasis
A4G16_04045	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G16_04050	COG4607	ABC-type enterochelin transport system periplasmic component
A4G16_04055	COG0305	Participates in initiation and elongation during chromosome replication
A4G16_04060	COG3100	YcgL domain-containing protein
A4G16_04065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4G16_04085	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
A4G16_04090	COG1823	symporter activity
A4G16_04095	COG0778	Nitroreductase
A4G16_04105	COG0072	phenylalanine-tRNA ligase activity
A4G16_04115	COG0791	NLP P60 protein
A4G16_04120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4G16_04130	COG0539	negative regulation of cytoplasmic translation
A4G16_04140	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A4G16_04145	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A4G16_04150	COG0284	orotidine-5'-phosphate decarboxylase activity
A4G16_04155	COG0023	Translation Initiation Factor
A4G16_04160	COG0737	Belongs to the 5'-nucleotidase family
A4G16_04165	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A4G16_04170	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A4G16_04175	COG0658	competence protein
A4G16_04175	COG2333	competence protein COMEC
A4G16_04185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A4G16_04195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4G16_04200	COG0625	glutathione transferase activity
A4G16_04205	COG2969	positive regulation of protein catabolic process
A4G16_04220	COG0583	DNA-binding transcription factor activity
A4G16_04240	COG2226	methyltransferase
A4G16_04245	COG3036	rescue of stalled ribosome
A4G16_04260	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4G16_04265	COG1940	carbohydrate kinase activity
A4G16_04265	COG1846	Transcriptional regulator
A4G16_04270	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A4G16_04275	COG1522	sequence-specific DNA binding
A4G16_04280	COG1674	ftsk spoiiie
A4G16_04285	COG2321	neutral zinc metallopeptidase
A4G16_04290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4G16_04295	COG1214	PFAM Peptidase M22, glycoprotease
A4G16_04300	COG1435	thymidine kinase activity
A4G16_04305	COG3074	FtsZ-dependent cytokinesis
A4G16_04310	COG1494	fructose-1,6-bisphosphatase
A4G16_04320	COG0006	proline dipeptidase activity
A4G16_04335	COG0697	spore germination
A4G16_04340	COG0440	acetolactate synthase activity
A4G16_04345	COG0028	Belongs to the TPP enzyme family
A4G16_04350	COG0288	reversible hydration of carbon dioxide
A4G16_04355	COG0857	belongs to the CobB CobQ family
A4G16_04355	COG0280	phosphate acetyltransferase
A4G16_04365	COG0737	Belongs to the 5'-nucleotidase family
A4G16_04375	COG0626	cystathionine gamma-synthase activity
A4G16_04380	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4G16_04390	COG2363	Small membrane protein
A4G16_04395	COG0243	molybdopterin cofactor binding
A4G16_04400	COG1049	propionate catabolic process, 2-methylcitrate cycle
A4G16_04405	COG0538	isocitrate dehydrogenase activity
A4G16_04425	COG0243	molybdopterin cofactor binding
A4G16_04430	COG3005	denitrification pathway
A4G16_04435	COG2197	response regulator
A4G16_04445	COG0315	cyclic pyranopterin monophosphate synthase activity
A4G16_04450	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A4G16_04455	COG0314	molybdopterin synthase activity
A4G16_04460	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4G16_04465	COG1444	tRNA N-acetyltransferase activity
A4G16_04470	COG1448	Aminotransferase
A4G16_04475	COG0285	dihydrofolate synthase activity
A4G16_04485	COG3956	TIGRFAM MazG family protein
A4G16_04490	COG0745	RESPONSE REGULATOR receiver
A4G16_04495	COG2205	protein histidine kinase activity
A4G16_04500	COG1136	(ABC) transporter
A4G16_04500	COG0577	efflux transmembrane transporter activity
A4G16_04505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4G16_04510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4G16_04515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4G16_04520	COG0556	nucleotide-excision repair
A4G16_04530	COG2837	iron assimilation
A4G16_04540	COG0613	PHP domain protein
A4G16_04550	COG2925	Exonuclease
A4G16_04555	COG0017	Asparaginyl-tRNA synthetase
A4G16_04560	COG1509	lysine 2,3-aminomutase activity
A4G16_04580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4G16_04585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4G16_04590	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4G16_04595	COG3081	Nucleoid-associated protein
A4G16_04625	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A4G16_04630	COG0312	modulator of DNA gyrase
A4G16_04635	COG3028	Belongs to the UPF0307 family
A4G16_04640	COG3094	Invasion gene expression up-regulator, SirB
A4G16_04645	COG1811	Na channel or pump
A4G16_04655	COG3787	Belongs to the UPF0306 family
A4G16_04665	COG4774	siderophore transport
A4G16_04675	COG0425	Belongs to the sulfur carrier protein TusA family
A4G16_04680	COG3945	hemerythrin HHE cation binding domain
A4G16_04695	COG1278	Cold shock
A4G16_04700	COG0697	spore germination
A4G16_04705	COG1737	Transcriptional regulator
A4G16_04710	COG2731	YhcH YjgK YiaL family protein
A4G16_04715	COG0248	Ppx GppA phosphatase
A4G16_04720	COG2926	Belongs to the UPF0265 family
A4G16_04725	COG0527	aspartate kinase activity
A4G16_04730	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A4G16_04735	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A4G16_04765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4G16_04770	COG1185	polyribonucleotide nucleotidyltransferase activity
A4G16_04775	COG4785	May be involved in cell division
A4G16_04780	COG0513	Belongs to the DEAD box helicase family
A4G16_04785	COG0590	tRNA wobble adenosine to inosine editing
A4G16_04790	COG2951	lytic endotransglycosylase activity
A4G16_04800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4G16_04805	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4G16_04810	COG0195	Participates in both transcription termination and antitermination
A4G16_04815	COG0779	Required for maturation of 30S ribosomal subunits
A4G16_04825	COG0741	lytic transglycosylase activity
A4G16_04830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4G16_04835	COG0739	heme binding
A4G16_04840	COG1121	(ABC) transporter
A4G16_04845	COG0567	Dehydrogenase, E1 component
A4G16_04850	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4G16_04855	COG0045	succinate-CoA ligase (ADP-forming) activity
A4G16_04860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4G16_04865	COG1115	amino acid carrier protein
A4G16_04870	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A4G16_04890	COG1518	maintenance of DNA repeat elements
A4G16_04925	COG1944	ATP diphosphatase activity
A4G16_04945	COG0500	methyltransferase
A4G16_04960	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A4G16_04980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4G16_04985	COG5002	protein histidine kinase activity
A4G16_04990	COG0745	RESPONSE REGULATOR receiver
A4G16_05000	COG0581	inorganic phosphate transmembrane transporter activity
A4G16_05010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4G16_05015	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4G16_05020	COG0575	Belongs to the CDS family
A4G16_05025	COG0750	zinc metalloprotease
A4G16_05040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4G16_05045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4G16_05050	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4G16_05055	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A4G16_05055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4G16_05060	COG0135	phosphoribosylanthranilate isomerase activity
A4G16_05060	COG0134	indole-3-glycerol-phosphate synthase activity
A4G16_05065	COG3098	single-species biofilm formation
A4G16_05070	COG0564	pseudouridine synthase activity
A4G16_05080	COG3025	triphosphatase activity
A4G16_05085	COG3106	COG3106 Predicted ATPase
A4G16_05090	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4G16_05115	COG0495	leucyl-tRNA aminoacylation
A4G16_05120	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A4G16_05125	COG1466	dna polymerase III delta subunit
A4G16_05130	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A4G16_05135	COG0237	dephospho-CoA kinase activity
A4G16_05155	COG1459	type II secretion system
A4G16_05160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4G16_05165	COG4969	Belongs to the N-Me-Phe pilin family
A4G16_05170	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4G16_05180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4G16_05185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A4G16_05190	COG0730	response to heat
A4G16_05195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4G16_05200	COG0617	tRNA 3'-terminal CCA addition
A4G16_05215	COG2975	iron-sulfur cluster assembly
A4G16_05220	COG0633	Ferredoxin
A4G16_05240	COG1442	glycosyl transferase family 8
A4G16_05240	COG1216	Glycosyl transferase, family 2
A4G16_05255	COG0822	iron-sulfur transferase activity
A4G16_05265	COG1959	2 iron, 2 sulfur cluster binding
A4G16_05275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4G16_05280	COG5002	protein histidine kinase activity
A4G16_05280	COG2198	Histidine kinase
A4G16_05280	COG0784	Response regulator, receiver
A4G16_05290	COG0697	spore germination
A4G16_05300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4G16_05305	COG2840	Smr protein MutS2
A4G16_05315	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A4G16_05325	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A4G16_05325	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A4G16_05330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4G16_05335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4G16_05345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4G16_05350	COG4166	transmembrane transport
A4G16_05360	COG0444	Belongs to the ABC transporter superfamily
A4G16_05365	COG4172	Belongs to the ABC transporter superfamily
A4G16_05370	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4G16_05385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4G16_05400	COG2274	protein secretion by the type I secretion system
A4G16_05410	COG1160	GTP binding
A4G16_05415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4G16_05415	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4G16_05420	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A4G16_05425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4G16_05430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4G16_05435	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A4G16_05440	COG0318	PFAM AMP-dependent synthetase and ligase
A4G16_05450	COG3026	antisigma factor binding
A4G16_05455	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
A4G16_05460	COG1595	DNA-templated transcription, initiation
A4G16_05470	COG0561	phosphatase activity
A4G16_05475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4G16_05480	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A4G16_05505	COG1074	ATP-dependent DNA helicase activity
A4G16_05510	COG0534	Mate efflux family protein
A4G16_05515	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4G16_05520	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4G16_05530	COG1643	Atp-dependent helicase
A4G16_05540	COG2990	Protein conserved in bacteria
A4G16_05545	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4G16_05555	COG2932	Transcriptional regulator
A4G16_05560	COG0791	NLP P60 protein
A4G16_05570	COG3381	protein complex oligomerization
A4G16_05590	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A4G16_05600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4G16_05600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4G16_05615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4G16_05620	COG0583	DNA-binding transcription factor activity
A4G16_05635	COG3306	glycosyltransferase involved in LPS biosynthesis
A4G16_05645	COG0438	transferase activity, transferring glycosyl groups
A4G16_05655	COG0254	rRNA binding
A4G16_05665	COG1702	phosphate starvation-inducible protein PhoH
A4G16_05680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A4G16_05685	COG0626	cystathionine gamma-synthase activity
A4G16_05690	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4G16_05700	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A4G16_05705	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4G16_05710	COG0564	pseudouridine synthase activity
A4G16_05730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4G16_05735	COG2814	Major facilitator Superfamily
A4G16_05745	COG1441	menaquinone biosynthetic process
A4G16_05750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4G16_05750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4G16_05760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4G16_05765	COG2027	D-alanyl-D-alanine carboxypeptidase
A4G16_05780	COG0138	bifunctional purine biosynthesis protein purh
A4G16_05790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4G16_05800	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A4G16_05810	COG0823	Involved in the tonB-independent uptake of proteins
A4G16_05815	COG3064	Membrane
A4G16_05815	COG3064	Membrane
A4G16_05820	COG0848	biopolymer transport protein
A4G16_05825	COG0811	peptide transport
A4G16_05830	COG0824	Thioesterase
A4G16_05840	COG1294	oxidase, subunit
A4G16_05845	COG1271	oxidase subunit
A4G16_05870	COG0494	nUDIX hydrolase
A4G16_05900	COG0271	Belongs to the BolA IbaG family
A4G16_05910	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4G16_05915	COG1678	Uncharacterized ACR, COG1678
A4G16_05925	COG0628	permease
A4G16_05930	COG1115	amino acid carrier protein
A4G16_05935	COG1525	nuclease
A4G16_05970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4G16_05975	COG0205	6-phosphofructokinase activity
A4G16_05990	COG0564	pseudouridine synthase activity
A4G16_05995	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4G16_06000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4G16_06005	COG1965	Belongs to the frataxin family
A4G16_06010	COG0514	ATP-dependent DNA helicase (RecQ)
A4G16_06020	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4G16_06025	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A4G16_06035	COG0564	pseudouridine synthase activity
A4G16_06045	COG1584	GPR1 FUN34 yaaH family protein
A4G16_06065	COG0861	Integral membrane protein TerC family
A4G16_06085	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
A4G16_06090	COG0489	protein tyrosine kinase activity
A4G16_06095	COG4166	transmembrane transport
A4G16_06100	COG2095	MarC family integral membrane protein
A4G16_06105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4G16_06110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4G16_06115	COG2354	Protein conserved in bacteria
A4G16_06125	COG3071	HemY protein
A4G16_06130	COG2959	enzyme of heme biosynthesis
A4G16_06140	COG0181	hydroxymethylbilane synthase activity
A4G16_06145	COG1012	belongs to the aldehyde dehydrogenase family
A4G16_06145	COG1454	alcohol dehydrogenase
A4G16_06160	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4G16_06160	COG1388	LysM domain
A4G16_06165	COG0802	atpase or kinase
A4G16_06180	COG1519	Transferase
A4G16_06200	COG0795	lipopolysaccharide-transporting ATPase activity
A4G16_06205	COG0795	lipopolysaccharide-transporting ATPase activity
A4G16_06215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4G16_06220	COG3593	DNA synthesis involved in DNA repair
A4G16_06225	COG1611	Belongs to the LOG family
A4G16_06230	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4G16_06250	COG0732	type I restriction modification DNA specificity domain
A4G16_06265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4G16_06300	COG2056	Na+-H+ antiporter family
A4G16_06305	COG0708	Exodeoxyribonuclease III
A4G16_06310	COG3117	lipopolysaccharide transmembrane transporter activity
A4G16_06315	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A4G16_06320	COG1137	ATPase activity
A4G16_06325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G16_06330	COG1660	Displays ATPase and GTPase activities
A4G16_06335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4G16_06350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4G16_06365	COG3058	Necessary for formate dehydrogenase activity
A4G16_06370	COG2864	formate dehydrogenase
A4G16_06375	COG0437	4 iron, 4 sulfur cluster binding
A4G16_06380	COG0243	molybdopterin cofactor binding
A4G16_06380	COG3383	formate dehydrogenase (NAD+) activity
A4G16_06390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A4G16_06400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4G16_06405	COG0215	cysteine-tRNA ligase activity
A4G16_06410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4G16_06435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4G16_06440	COG1280	lysine exporter protein (LysE YggA)
A4G16_06445	COG2962	Rard protein
A4G16_06450	COG0436	Aminotransferase
A4G16_06465	COG0602	queuosine metabolic process
A4G16_06470	COG0720	synthase
A4G16_06480	COG2960	long-chain fatty acid transporting porin activity
A4G16_06485	COG0166	Belongs to the GPI family
A4G16_06495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4G16_06505	COG0778	Nitroreductase
A4G16_06510	COG4172	Belongs to the ABC transporter superfamily
A4G16_06515	COG0191	fructose-bisphosphate aldolase activity
A4G16_06520	COG0126	phosphoglycerate kinase activity
A4G16_06525	COG0733	neurotransmitter:sodium symporter activity
A4G16_06530	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A4G16_06535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4G16_06540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4G16_06545	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A4G16_06570	COG4796	Type ii and iii secretion system protein
A4G16_06575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4G16_06580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A4G16_06585	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A4G16_06590	COG1280	lysine exporter protein (LysE YggA)
A4G16_06595	COG0632	four-way junction helicase activity
A4G16_06600	COG2255	four-way junction helicase activity
A4G16_06610	COG0601	transmembrane transport
A4G16_06615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4G16_06620	COG4172	Belongs to the ABC transporter superfamily
A4G16_06625	COG0653	protein targeting
A4G16_06640	COG0646	methionine synthase
A4G16_06640	COG1410	methionine synthase
A4G16_06645	COG2814	Major facilitator Superfamily
A4G16_06650	COG1120	ATPase activity
A4G16_06660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4G16_06675	COG2268	Band 7 protein
A4G16_06680	COG2841	Protein conserved in bacteria
A4G16_06690	COG0210	DNA helicase
A4G16_06695	COG1090	epimerase
A4G16_06715	COG1666	GTP binding
A4G16_06720	COG0560	Phosphoserine phosphatase
A4G16_06730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4G16_06745	COG2081	HI0933 family
A4G16_06750	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A4G16_06755	COG2252	PERMEase
A4G16_06770	COG0716	FMN binding
A4G16_06775	COG0735	belongs to the Fur family
A4G16_06780	COG3008	intermembrane lipid transfer
A4G16_06785	COG1854	S-ribosylhomocysteine lyase activity
A4G16_06790	COG1132	(ABC) transporter
A4G16_06810	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4G16_06815	COG0592	DNA-directed DNA polymerase activity
A4G16_06820	COG2976	Protein conserved in bacteria
A4G16_06830	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4G16_06835	COG1426	Protein conserved in bacteria
A4G16_06840	COG0165	Argininosuccinate lyase
A4G16_06850	COG2991	Protein conserved in bacteria
A4G16_06855	COG1477	protein flavinylation
A4G16_06860	COG2871	sodium ion transport
A4G16_06865	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A4G16_06870	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A4G16_06875	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A4G16_06880	COG1805	sodium ion transport
A4G16_06890	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A4G16_06890	COG0316	Belongs to the HesB IscA family
A4G16_06905	COG2194	sulfuric ester hydrolase activity
A4G16_06915	COG0583	DNA-binding transcription factor activity
A4G16_06920	COG1011	Hydrolase
A4G16_06925	COG0583	DNA-binding transcription factor activity
A4G16_06930	COG1162	GTPase activity
A4G16_06940	COG0537	adenosine 5'-monophosphoramidase activity
A4G16_06950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4G16_06955	COG3108	Peptidase M15
A4G16_06960	COG2989	Protein conserved in bacteria
A4G16_06965	COG0793	Belongs to the peptidase S41A family
A4G16_06970	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A4G16_06980	COG2814	Major facilitator Superfamily
A4G16_06985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4G16_06995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4G16_07015	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4G16_07020	COG0792	nuclease activity
A4G16_07025	COG3107	peptidoglycan biosynthetic process
A4G16_07035	COG1858	cytochrome C peroxidase
A4G16_07045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4G16_07050	COG1414	Transcriptional regulator
A4G16_07055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4G16_07065	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A4G16_07080	COG3068	Protein conserved in bacteria
A4G16_07150	COG0497	DNA recombination
A4G16_07155	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A4G16_07165	COG0849	cell division
A4G16_07175	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4G16_07185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4G16_07190	COG0772	Belongs to the SEDS family
A4G16_07195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4G16_07200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4G16_07205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4G16_07210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4G16_07215	COG0768	penicillin binding
A4G16_07220	COG3116	cell division
A4G16_07240	COG0557	exoribonuclease II activity
A4G16_07245	COG2824	Alkylphosphonate utilization operon protein PhnA
A4G16_07255	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A4G16_07265	COG1755	Isoprenylcysteine carboxyl methyltransferase
A4G16_07270	COG1530	ribonuclease E activity
A4G16_07285	COG1652	LysM domain
A4G16_07295	COG2153	protein acetylation
A4G16_07305	COG0525	valine-tRNA ligase activity
A4G16_07310	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4G16_07320	COG0363	glucosamine-6-phosphate deaminase activity
A4G16_07325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4G16_07330	COG1218	3'(2'),5'-bisphosphate nucleotidase
A4G16_07335	COG0494	nUDIX hydrolase
A4G16_07340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4G16_07355	COG0107	imidazoleglycerol-phosphate synthase activity
A4G16_07360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A4G16_07365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4G16_07375	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4G16_07375	COG0131	Imidazoleglycerol-phosphate dehydratase
A4G16_07410	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A4G16_07415	COG0456	acetyltransferase
A4G16_07425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4G16_07430	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A4G16_07440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4G16_07455	COG2391	methyltransferase activity
A4G16_07465	COG1045	serine acetyltransferase
A4G16_07470	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4G16_07475	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A4G16_07480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4G16_07485	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4G16_07500	COG0049	tRNA binding
A4G16_07505	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4G16_07510	COG0859	PFAM glycosyl transferase family 9
A4G16_07515	COG0859	PFAM glycosyl transferase family 9
A4G16_07525	COG3266	domain, Protein
A4G16_07525	COG3061	Opacity-associated protein A
A4G16_07530	COG1555	photosystem II stabilization
A4G16_07535	COG0688	phosphatidylethanolamine metabolic process
A4G16_07545	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G16_07545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G16_07550	COG3715	PTS system
A4G16_07555	COG3716	PTS system mannose fructose sorbose family IID component
A4G16_07570	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A4G16_07575	COG1238	metal cluster binding
A4G16_07590	COG1388	LysM domain
A4G16_07590	COG4942	peptidase
A4G16_07600	COG2818	Glycosylase
A4G16_07610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4G16_07620	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4G16_07625	COG0762	integral membrane protein
A4G16_07630	COG3171	Protein conserved in bacteria
A4G16_07635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4G16_07640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4G16_07645	COG0676	glucose-6-phosphate 1-epimerase activity
A4G16_07650	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A4G16_07655	COG0746	molybdenum cofactor guanylyltransferase activity
A4G16_07660	COG3084	Protein conserved in bacteria
A4G16_07665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4G16_07670	COG3691	Protein conserved in bacteria
A4G16_07675	COG0513	Belongs to the DEAD box helicase family
A4G16_07680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4G16_07685	COG0733	neurotransmitter:sodium symporter activity
A4G16_07690	COG4536	flavin adenine dinucleotide binding
A4G16_07695	COG4137	Cytochrome C assembly protein
A4G16_07700	COG1399	metal-binding, possibly nucleic acid-binding protein
A4G16_07705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A4G16_07710	COG0416	fatty acid biosynthetic process
A4G16_07730	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
A4G16_07735	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
A4G16_07740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4G16_07745	COG2995	paraquat-inducible protein a
A4G16_07750	COG1289	transmembrane transporter activity
A4G16_07755	COG1803	Methylglyoxal synthase
A4G16_07760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4G16_07765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4G16_07765	COG0678	peroxiredoxin activity
A4G16_07775	COG1309	transcriptional regulator
A4G16_07795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4G16_07800	COG2853	Lipoprotein
A4G16_07805	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A4G16_07810	COG3924	membrane
A4G16_07815	COG4145	pantothenate transmembrane transporter activity
A4G16_07820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4G16_07830	COG2091	lysine biosynthetic process via aminoadipic acid
A4G16_07840	COG0494	nUDIX hydrolase
A4G16_07860	COG1312	Catalyzes the dehydration of D-mannonate
A4G16_07865	COG2186	Transcriptional regulator
A4G16_07870	COG1028	Short-chain dehydrogenase reductase Sdr
A4G16_07895	COG0800	Aldolase
A4G16_07900	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4G16_07915	COG3005	denitrification pathway
A4G16_07925	COG3005	denitrification pathway
A4G16_07930	COG3043	anaerobic respiration
A4G16_07935	COG0348	domain, Protein
A4G16_07940	COG0437	4 iron, 4 sulfur cluster binding
A4G16_07945	COG0243	molybdopterin cofactor binding
A4G16_07950	COG3062	negative regulation of establishment of protein localization
A4G16_07955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4G16_07960	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4G16_07965	COG0076	glutamate decarboxylase activity
A4G16_07970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4G16_07980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4G16_07985	COG2003	Belongs to the UPF0758 family
A4G16_07990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4G16_08000	COG1309	transcriptional regulator
A4G16_08015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4G16_08020	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A4G16_08020	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A4G16_08025	COG0747	negative chemotaxis
A4G16_08040	COG0477	Major facilitator Superfamily
A4G16_08055	COG1566	PFAM secretion protein HlyD family protein
A4G16_08080	COG0730	response to heat
A4G16_08090	COG0546	phosphoglycolate phosphatase activity
A4G16_08095	COG0180	Tryptophanyl-tRNA synthetase
A4G16_08100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4G16_08105	COG3119	arylsulfatase activity
A4G16_08125	COG0641	radical SAM
A4G16_08130	COG0730	response to heat
A4G16_08135	COG0501	Belongs to the peptidase M48B family
A4G16_08140	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A4G16_08160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4G16_08170	COG0470	DNA polymerase III
A4G16_08175	COG0084	hydrolase, TatD family'
A4G16_08185	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4G16_08190	COG1215	transferase activity, transferring glycosyl groups
A4G16_08220	COG1793	dna ligase
A4G16_08225	COG3630	sodium ion export across plasma membrane
A4G16_08235	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A4G16_08240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4G16_08250	COG3133	Outer membrane lipoprotein
A4G16_08255	COG3102	Protein conserved in bacteria
A4G16_08260	COG0018	arginyl-trna synthetase
A4G16_08265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4G16_08285	COG1138	Cytochrome C-type biogenesis protein
A4G16_08295	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4G16_08300	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4G16_08305	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4G16_08310	COG4133	protoheme IX ABC transporter activity
A4G16_08315	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4G16_08320	COG0747	negative chemotaxis
A4G16_08325	COG0601	transmembrane transport
A4G16_08330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4G16_08335	COG0444	Belongs to the ABC transporter superfamily
A4G16_08340	COG4608	Belongs to the ABC transporter superfamily
A4G16_08345	COG0616	signal peptide processing
A4G16_08350	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4G16_08355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4G16_08360	COG1758	RNA polymerase activity
A4G16_08375	COG1621	beta-fructofuranosidase activity
A4G16_08380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G16_08385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4G16_08390	COG2190	(PTS) system
A4G16_08395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4G16_08400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4G16_08405	COG1178	ABC-type Fe3 transport system permease component
A4G16_08410	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A4G16_08420	COG0024	Methionine aminopeptidase
A4G16_08425	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A4G16_08440	COG0805	protein transport
A4G16_08445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4G16_08450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4G16_08455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A4G16_08465	COG2226	methyltransferase
A4G16_08470	COG0598	Magnesium transport protein CorA
A4G16_08480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4G16_08490	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4G16_08495	COG2259	Doxx family
A4G16_08500	COG1040	competence protein
A4G16_08505	COG0561	phosphatase activity
A4G16_08510	COG0697	spore germination
A4G16_08520	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4G16_08525	COG0142	geranyltranstransferase activity
A4G16_08530	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4G16_08535	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4G16_08540	COG1028	Short-chain dehydrogenase reductase Sdr
A4G16_08545	COG1114	Component of the transport system for branched-chain amino acids
A4G16_08555	COG1490	D-aminoacyl-tRNA deacylase activity
A4G16_08560	COG1295	ribonuclease BN
A4G16_08590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4G16_08610	COG0347	Belongs to the P(II) protein family
A4G16_08640	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A4G16_08645	COG0783	Belongs to the Dps family
A4G16_08650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4G16_08655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A4G16_08665	COG0425	Belongs to the sulfur carrier protein TusA family
A4G16_08670	COG2391	methyltransferase activity
A4G16_08680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4G16_08685	COG1393	Belongs to the ArsC family
A4G16_08690	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4G16_08695	COG0564	pseudouridine synthase activity
A4G16_08705	COG0668	transmembrane transport
A4G16_08710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4G16_08720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A4G16_08745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4G16_08755	COG3120	sequence-specific DNA binding
A4G16_08765	COG0247	lactate metabolic process
A4G16_08765	COG0277	FAD linked oxidase domain protein
A4G16_08785	COG0204	Acyl-transferase
A4G16_08795	COG0825	malonyl-CoA metabolic process
A4G16_08840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4G16_08855	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4G16_08870	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4G16_08875	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A4G16_08880	COG3085	chromosome segregation
A4G16_08900	COG2832	Protein of unknown function (DUF454)
A4G16_08920	COG2964	Protein conserved in bacteria
A4G16_08925	COG0814	amino acid
A4G16_08950	COG4545	Glutaredoxin-related protein
A4G16_08965	COG4211	Belongs to the binding-protein-dependent transport system permease family
A4G16_08970	COG1129	ABC transporter
A4G16_08975	COG1879	ABC-type sugar transport system periplasmic component
A4G16_08980	COG3691	Protein conserved in bacteria
A4G16_09010	COG0606	chelatase, subunit chli
A4G16_09020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4G16_09025	COG2885	chlorophyll binding
A4G16_09025	COG3047	cAMP biosynthetic process
A4G16_09030	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4G16_09035	COG0742	ribosomal rna small subunit methyltransferase
A4G16_09040	COG1876	peptidase activity
A4G16_09050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4G16_09060	COG0511	ligase activity, forming carbon-carbon bonds
A4G16_09065	COG0439	Biotin carboxylase
A4G16_09070	COG2850	peptidyl-arginine hydroxylation
A4G16_09075	COG1694	Mazg nucleotide pyrophosphohydrolase
A4G16_09085	COG0336	Belongs to the RNA methyltransferase TrmD family
A4G16_09090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A4G16_09095	COG0228	four-way junction DNA binding
A4G16_09110	COG0202	RNA polymerase activity
A4G16_09115	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4G16_09135	COG0201	protein transport
A4G16_09140	COG0200	Binds to the 23S rRNA
A4G16_09150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4G16_09160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4G16_09165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4G16_09205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A4G16_09210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4G16_09215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4G16_09225	COG0089	rRNA binding
A4G16_09230	COG0088	Forms part of the polypeptide exit tunnel
A4G16_09235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4G16_09240	COG0051	transcription antitermination factor activity, RNA binding
A4G16_09245	COG3070	regulator of competence-specific genes
A4G16_09255	COG0019	diaminopimelate decarboxylase activity
A4G16_09260	COG0625	glutathione transferase activity
A4G16_09270	COG2264	protein methyltransferase activity
A4G16_09295	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A4G16_09300	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A4G16_09305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4G16_09310	COG1053	succinate dehydrogenase
A4G16_09315	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A4G16_09335	COG0728	peptidoglycan biosynthetic process
A4G16_09345	COG1970	mechanosensitive ion channel activity
A4G16_09355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4G16_09360	COG1739	Uncharacterized protein family UPF0029
A4G16_09370	COG1119	ATPase activity
A4G16_09380	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A4G16_09390	COG2986	histidine ammonia-lyase
A4G16_09395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4G16_09400	COG0321	lipoyl(octanoyl) transferase activity
A4G16_09405	COG2921	Belongs to the UPF0250 family
A4G16_09410	COG1686	Belongs to the peptidase S11 family
A4G16_09415	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4G16_09420	COG0772	Belongs to the SEDS family
A4G16_09425	COG0768	penicillin binding
A4G16_09455	COG0471	metal ion transport
A4G16_09455	COG0490	domain, Protein
A4G16_09490	COG0545	Peptidyl-prolyl cis-trans isomerase
A4G16_09495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4G16_09510	COG0037	tRNA processing
A4G16_09515	COG4974	Belongs to the 'phage' integrase family
A4G16_09570	COG3161	chorismate lyase activity
A4G16_09575	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A4G16_09585	COG1522	sequence-specific DNA binding
A4G16_09590	COG2502	aspartate--ammonia ligase
A4G16_09620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4G16_09625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A4G16_09650	COG0204	Acyl-transferase
A4G16_09650	COG0318	PFAM AMP-dependent synthetase and ligase
A4G16_09655	COG3477	response to acidic pH
A4G16_09660	COG0357	Ribosomal RNA small subunit methyltransferase G
A4G16_09670	COG0445	tRNA wobble uridine modification
A4G16_09675	COG3012	SEC-C Motif Domain Protein
A4G16_09685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4G16_09690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4G16_09690	COG1522	sequence-specific DNA binding
A4G16_09700	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4G16_09710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4G16_09725	COG0442	prolyl-tRNA aminoacylation
A4G16_09735	COG0716	FMN binding
A4G16_09750	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A4G16_09755	COG1921	L-seryl-tRNASec selenium transferase activity
A4G16_09770	COG3276	selenocysteine insertion sequence binding
A4G16_09775	COG2358	TRAP transporter, solute receptor (TAXI family
A4G16_09790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4G16_09795	COG0569	domain protein
A4G16_09800	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4G16_09805	COG2731	YhcH YjgK YiaL family protein
A4G16_09810	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4G16_09815	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4G16_09820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4G16_09825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4G16_09830	COG1129	ABC transporter
A4G16_09855	COG4575	ribosome binding
A4G16_09875	COG2271	Major facilitator Superfamily
A4G16_09880	COG0584	glycerophosphoryl diester phosphodiesterase
A4G16_09885	COG2271	Major facilitator Superfamily
A4G16_09890	COG3842	ATPase activity
A4G16_09900	COG1840	ABC-type Fe3 transport system, periplasmic component
A4G16_09905	COG1840	ABC-type Fe3 transport system, periplasmic component
A4G16_09935	COG0346	lactoylglutathione lyase activity
A4G16_09940	COG1194	a g-specific adenine glycosylase
A4G16_09945	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A4G16_09950	COG0741	lytic transglycosylase activity
A4G16_09975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4G16_09990	COG1929	Belongs to the glycerate kinase type-1 family
A4G16_09995	COG2610	gluconate transmembrane transporter activity
A4G16_10000	COG3835	regulator
A4G16_10015	COG1328	CTP reductase activity
A4G16_10020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4G16_10025	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
A4G16_10040	COG2900	Belongs to the SlyX family
A4G16_10045	COG0545	Peptidyl-prolyl cis-trans isomerase
A4G16_10050	COG2964	Protein conserved in bacteria
A4G16_10055	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A4G16_10065	COG2168	tRNA wobble position uridine thiolation
A4G16_10075	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A4G16_10085	COG3700	Belongs to the class B bacterial acid phosphatase family
A4G16_10105	COG3623	hexulose-6-phosphate isomerase
A4G16_10110	COG0235	Class ii aldolase
A4G16_10125	COG1349	DNA-binding transcription factor activity
A4G16_10130	COG2084	Dehydrogenase
A4G16_10135	COG3395	kinase activity
A4G16_10140	COG0235	Class ii aldolase
A4G16_10145	COG3622	Belongs to the hyi family
A4G16_10150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4G16_10155	COG2610	gluconate transmembrane transporter activity
A4G16_10165	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A4G16_10170	COG1126	abc transporter atp-binding protein
A4G16_10175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4G16_10180	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4G16_10190	COG3545	Serine hydrolase
A4G16_10220	COG1070	Carbohydrate kinase
A4G16_10230	COG4213	ABC transporter substrate-binding protein
A4G16_10235	COG1129	ABC transporter
A4G16_10240	COG4214	carbohydrate transport
A4G16_10245	COG1609	Transcriptional regulator
A4G16_10245	COG2207	Transcriptional regulator
A4G16_10250	COG1609	Transcriptional regulator
A4G16_10265	COG4206	TonB-dependent receptor
A4G16_10265	COG1629	transport
A4G16_10270	COG3265	gluconokinase activity
A4G16_10280	COG0583	DNA-binding transcription factor activity
A4G16_10290	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4G16_10295	COG1012	belongs to the aldehyde dehydrogenase family
A4G16_10300	COG3718	enzyme involved in inositol metabolism
A4G16_10310	COG1879	ABC-type sugar transport system periplasmic component
A4G16_10315	COG1129	ABC transporter
A4G16_10320	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4G16_10325	COG0673	inositol 2-dehydrogenase activity
A4G16_10330	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A4G16_10330	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
A4G16_10335	COG3051	citrate lyase alpha subunit
A4G16_10340	COG2301	Belongs to the HpcH HpaI aldolase family
A4G16_10345	COG3052	prosthetic group binding
A4G16_10350	COG2828	Protein conserved in bacteria
A4G16_10355	COG0471	metal ion transport
A4G16_10360	COG2188	Transcriptional regulator
A4G16_10370	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
A4G16_10375	COG0673	inositol 2-dehydrogenase activity
A4G16_10385	COG3962	Belongs to the TPP enzyme family
A4G16_10400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4G16_10400	COG2190	(PTS) system
A4G16_10400	COG1263	PTS System
A4G16_10410	COG0673	inositol 2-dehydrogenase activity
A4G16_10425	COG1595	DNA-templated transcription, initiation
A4G16_10430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A4G16_10440	COG0252	asparaginase activity
A4G16_10465	COG1349	DNA-binding transcription factor activity
A4G16_10470	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
A4G16_10475	COG1070	Carbohydrate kinase
A4G16_10480	COG4154	Belongs to the RbsD FucU family
A4G16_10485	COG0235	Class ii aldolase
A4G16_10490	COG0738	Major facilitator superfamily
A4G16_10495	COG1454	alcohol dehydrogenase
A4G16_10505	COG1349	DNA-binding transcription factor activity
A4G16_10510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4G16_10515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4G16_10520	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4G16_10525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4G16_10540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4G16_10545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4G16_10550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4G16_10550	COG1116	anion transmembrane transporter activity
A4G16_10560	COG1305	Transglutaminase-like
A4G16_10570	COG2608	mercury ion transmembrane transporter activity
A4G16_10575	COG0517	IMP dehydrogenase activity
A4G16_10575	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A4G16_10585	COG0758	DNA mediated transformation
A4G16_10590	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4G16_10600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A4G16_10610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A4G16_10635	COG0085	RNA polymerase activity
A4G16_10660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4G16_10670	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A4G16_10675	COG0456	acetyltransferase
A4G16_10680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4G16_10685	COG0174	glutamine synthetase
A4G16_10700	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity