locus-tag class description BG574_00005 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BG574_00015 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BG574_00030 ENOG4105CPC Aldo Keto reductase BG574_00035 ENOG4105CXY transporter BG574_00040 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase BG574_00045 ENOG4105CXY transporter BG574_00060 ENOG41076KX Protein of unknown function (DUF1469) BG574_00070 ENOG4105CMG Carbohydrate kinase BG574_00085 ENOG4107SDZ Galactoside transport system permease protein mglC BG574_00090 ENOG4105C2J ABC transporter BG574_00095 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BG574_00100 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BG574_00105 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BG574_00110 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter BG574_00115 ENOG4108R66 Conserved Protein BG574_00120 ENOG4105DG4 malate L-lactate dehydrogenase BG574_00130 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BG574_00135 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BG574_00150 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BG574_00155 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BG574_00160 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BG574_00165 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BG574_00170 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BG574_00175 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BG574_00185 ENOG4105CU9 asparagine synthetase A BG574_00190 ENOG4108VVK transcriptional Regulator, AsnC BG574_00200 ENOG4105QTB Flavodoxin BG574_00205 ENOG4105DEF Extracellular solute-binding protein, family 5 BG574_00220 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BG574_00225 ENOG4105EVU fructokinase BG574_00230 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) BG574_00240 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) BG574_00245 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) BG574_00255 ENOG4105EM7 Selenocysteine-specific translation elongation factor BG574_00275 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BG574_00280 ENOG4105C1A potassium transporter peripheral membrane BG574_00285 ENOG4105R3P Inner membrane protein yagU BG574_00290 ENOG4105C26 Dehydrogenase BG574_00295 ENOG4105C0A alcohol dehydrogenase BG574_00300 ENOG4105CI1 PTS System BG574_00305 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BG574_00310 ENOG4105CNN ABC, transporter BG574_00315 ENOG4105C2J ABC transporter BG574_00320 ENOG4107W7X Aldolase BG574_00325 ENOG4105NWF RbsD or FucU transport BG574_00330 ENOG4105CMG Carbohydrate kinase BG574_00335 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) BG574_00340 ENOG4107EDW L-fucose operon activator BG574_00360 ENOG4108ETH Formylglycinamide ribotide synthetase BG574_00365 ENOG41063SR receptor BG574_00385 ENOG4105HDK L-asparaginase BG574_00400 ENOG4105DFD Na H antiporter BG574_00405 ENOG4105C8Y Acetylornithine aminotransferase BG574_00415 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) BG574_00420 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) BG574_00425 ENOG4108WQI RNA Polymerase BG574_00440 ENOG4105D9R oxidoreductase BG574_00445 ENOG4108KS2 transglutaminase domain protein BG574_00455 ENOG410681U heavy metal transport detoxification protein BG574_00460 ENOG410787A Pts system, glucitol sorbitol-specific BG574_00465 ENOG4105DZY Pts system, glucitol sorbitol-specific BG574_00470 ENOG4105VI0 Pts system, glucitol sorbitol-specific BG574_00475 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase BG574_00480 ENOG4105J92 DNA-binding transcriptional activator GutM BG574_00485 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 BG574_00490 ENOG410804X Transcriptional regulator BG574_00495 ENOG4105C2X Arabinose 5-phosphate isomerase BG574_00505 ENOG4105CTS PTS system mannitol-specific BG574_00515 ENOG4105E61 Mannitol repressor protein BG574_00520 ENOG4107QWE )-transporter BG574_00525 ENOG4108HWW ABC transporter BG574_00530 ENOG4105C2J ABC transporter BG574_00535 ENOG4105DFW ABC transporter BG574_00540 ENOG4105C93 Xylose Isomerase BG574_00545 ENOG4105CMG Carbohydrate kinase BG574_00555 ENOG4105MJ9 esterase BG574_00565 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BG574_00575 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BG574_00580 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BG574_00600 ENOG4105I5W Transporter BG574_00610 ENOG4105C42 Type I secretion membrane fusion protein (HlyD BG574_00615 ENOG4108JJA ABC, transporter BG574_00630 ENOG4106PMH Extracellular solute-binding protein family 3 BG574_00635 ENOG4108MJ5 VirK protein BG574_00640 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BG574_00645 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BG574_00660 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BG574_00665 ENOG4105CEN a g-specific adenine glycosylase BG574_00670 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) BG574_00675 ENOG4105E4C Lytic transglycosylase catalytic BG574_00700 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY BG574_00705 ENOG4105MVE transcriptional regulator BG574_00710 ENOG4105ZXK Dehydrogenase BG574_00715 ENOG4105G63 Type III effector Hrp-dependent BG574_00720 ENOG4105FB2 class II Aldolase BG574_00725 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) BG574_00730 ENOG4105C6Z Gluconate BG574_00745 ENOG4105D4P Coproporphyrinogen iii oxidase BG574_00760 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BG574_00765 ENOG41063VX Inherit from COG: glutaredoxin-related protein BG574_00770 ENOG4105DFS Conserved Protein BG574_00795 ENOG4105WWK YheO domain protein BG574_00810 ENOG4105WD1 Membrane BG574_00830 ENOG4108WFC UPF0438 protein yifE BG574_00835 ENOG410863D Flavinator of succinate dehydrogenase BG574_00845 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BG574_00850 ENOG4108YZA Nitrogen regulatory protein pii BG574_00855 ENOG4108RIR Molybdenum cofactor biosynthesis protein BG574_00860 ENOG4108M1T Cytochrome c-type biogenesis protein BG574_00865 ENOG4108M1T Cytochrome c-type biogenesis protein BG574_00875 ENOG4107QX9 Thiol disulfide interChange protein BG574_00910 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BG574_00915 ENOG4107RCV ABC transporter, permease BG574_00920 ENOG4105C4Y ABC transporter BG574_00930 ENOG410804X Transcriptional regulator BG574_00935 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BG574_00940 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BG574_00945 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BG574_00950 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BG574_00955 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BG574_00960 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BG574_00965 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BG574_00970 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BG574_00975 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BG574_00980 ENOG4105VPB 50S ribosomal protein L30 BG574_00985 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BG574_00990 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BG574_01000 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BG574_01005 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BG574_01010 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BG574_01015 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BG574_01020 ENOG4108ZT0 50S ribosomal protein l17 BG574_01025 ENOG4105T16 Transcriptional regulator (AraC family) BG574_01030 ENOG4105DIQ Transcriptional regulator BG574_01035 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family BG574_01040 ENOG4105C6Z Gluconate BG574_01055 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BG574_01060 ENOG4105C26 Dehydrogenase BG574_01065 ENOG4105DH8 myo-inositol catabolism BG574_01070 ENOG4105C26 Dehydrogenase BG574_01075 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BG574_01080 ENOG4105C2J ABC transporter BG574_01085 ENOG4105CNN ABC, transporter BG574_01105 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BG574_01110 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BG574_01115 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) BG574_01130 ENOG4105CK1 PTS System BG574_01140 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane BG574_01150 ENOG4105K5M 30s ribosomal protein S16 BG574_01155 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BG574_01160 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BG574_01165 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BG574_01180 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BG574_01185 ENOG4105EZE Cupin 4 family protein BG574_01190 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BG574_01195 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein BG574_01200 ENOG4108ST3 glycosyltransferase BG574_01205 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BG574_01215 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BG574_01230 ENOG41063M6 Cell Division Protein BG574_01235 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BG574_01245 ENOG4105C0P Mg chelatase subunit ChlI BG574_01250 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BG574_01260 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BG574_01265 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ BG574_01280 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BG574_01285 ENOG4105KZW UPF0381 protein BG574_01295 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator BG574_01300 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator BG574_01305 ENOG4105C2J ABC transporter BG574_01310 ENOG4108HWV )-transporter BG574_01315 ENOG4105DEF Extracellular solute-binding protein, family 5 BG574_01320 ENOG4105DEF Extracellular solute-binding protein, family 5 BG574_01350 ENOG4105DSY exodeoxyribonuclease V, gamma BG574_01355 ENOG4107QXK peptidase BG574_01360 ENOG4105DEF Extracellular solute-binding protein, family 5 BG574_01380 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BG574_01385 ENOG4105D4A Cell wall formation (By similarity) BG574_01390 ENOG4107RYR Transcriptional regulator, Crp Fnr family BG574_01395 ENOG4105YP7 UPF0270 protein BG574_01400 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) BG574_01405 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BG574_01425 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BG574_01430 ENOG4105W5Q DNA repair protein (RadC BG574_01445 ENOG4105MVE transcriptional regulator BG574_01460 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) BG574_01465 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BG574_01470 ENOG4108JPW Aminotransferase BG574_01475 ENOG4105DY8 decarboxylase BG574_01480 ENOG4105H4F exported protein BG574_01485 ENOG4105DYS nad(p)h dehydrogenase (quinone) BG574_01500 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BG574_01505 ENOG4108BGM Quinol dehydrogenase periplasmic component BG574_01510 ENOG4105GXZ Ferredoxin-type protein NapH BG574_01515 ENOG4105IYZ Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) BG574_01520 ENOG4105CUW cytochrome C-TYPE protein BG574_01525 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) BG574_01545 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) BG574_01565 ENOG41087AY ADP-Ribose pyrophosphatase BG574_01575 ENOG4105W8Z 4'-phosphopantetheinyl transferase BG574_01585 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BG574_01590 ENOG4108IA2 Sodium pantothenate symporter BG574_01595 ENOG4105RG0 Membrane BG574_01600 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) BG574_01605 ENOG410903C (LipO)protein BG574_01610 ENOG4105DFU Cell wall formation (By similarity) BG574_01645 ENOG4108J1Q BG574_01650 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BG574_01655 ENOG4105DJV ribulose-phosphate 3-epimerase BG574_01660 ENOG4105NRA 50s ribosomal protein l31 type b BG574_01665 ENOG4105YK5 50S ribosomal protein L36 BG574_01670 ENOG4105EAB amino acid AbC transporter BG574_01675 ENOG4105E5Q amino acid AbC transporter BG574_01680 ENOG4105CDA abc transporter atp-binding protein BG574_01685 ENOG4108VIA integral membrane protein BG574_01690 ENOG41090ED Protein with unknown function (DUF469) BG574_01695 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BG574_01700 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BG574_01705 ENOG4105D52 delta-aminolevulinic acid dehydratase BG574_01710 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BG574_01715 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) BG574_01720 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BG574_01725 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BG574_01730 ENOG4105DFS Conserved Protein BG574_01735 ENOG4105JC1 sterol-binding domain protein BG574_01740 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BG574_01745 ENOG4107QUT magnesium and cobalt transport protein CorA BG574_01760 ENOG4108J1Q BG574_01765 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) BG574_01795 ENOG4105XB7 anti-repressor protein BG574_01835 ENOG4108PNI recT protein BG574_01925 ENOG4105RWQ Protein of unknown function (DUF1364) BG574_01960 ENOG4105NVB glycoside hydrolase, family 19 BG574_01975 ENOG41061CV Terminase small subunit BG574_01980 ENOG4108N0N Phage Terminase Large Subunit BG574_02040 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin BG574_02045 ENOG41063XI Toxic component of a toxin-antitoxin (TA) module. A BG574_02140 ENOG4108RCM Nitroreductase BG574_02145 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BG574_02155 ENOG4108YYH Nadph-dependent fmn reductase BG574_02165 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) BG574_02175 ENOG4105EI2 Pseudouridine synthase BG574_02180 ENOG4105EEI dihydropteroate synthase BG574_02185 ENOG4105KUZ arsenate reductase BG574_02190 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BG574_02195 ENOG4105EEQ Na H antiporter BG574_02200 ENOG4105CUC YeeE YedE family protein BG574_02205 ENOG4105CUC YeeE YedE family protein BG574_02215 ENOG4105CH6 catalase BG574_02230 ENOG4105CFG Acts as a chaperone (By similarity) BG574_02235 ENOG4108YZA Nitrogen regulatory protein pii BG574_02260 ENOG4108J1Q BG574_02265 ENOG4108R3E Dna-3-methyladenine glycosylase i BG574_02275 ENOG4108K5P (LipO)protein BG574_02290 ENOG4108UM1 dedA family BG574_02295 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) BG574_02300 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) BG574_02310 ENOG4108NK4 UPF0266 membrane protein BG574_02315 ENOG4105F3R pts system mannose fructose sorbose family iid BG574_02320 ENOG4105ETZ PTS System BG574_02325 ENOG4108EQA pts system BG574_02330 ENOG4105D9M gamma-glutamylcysteine synthetase BG574_02360 ENOG4108F3G Type I restriction-modification system, R subunit BG574_02365 ENOG4105DJ4 phosphatidylserine decarboxylase BG574_02370 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein BG574_02375 ENOG4108UBT opacity-associated protein BG574_02385 ENOG4105XA0 heptosyltransferase ii BG574_02390 ENOG4105D16 lipopolysaccharide heptosyltransferase i BG574_02395 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BG574_02400 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BG574_02405 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BG574_02415 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BG574_02420 ENOG4107YZP Rhodanese domain protein BG574_02425 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) BG574_02430 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BG574_02435 ENOG4105D7W serine acetyltransferase BG574_02455 ENOG4105DFP Integrase BG574_02465 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG574_02490 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase BG574_02495 ENOG4105DFA alanine racemase domain protein BG574_02500 ENOG4105CI3 gtp-binding protein typa BG574_02505 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BG574_02510 ENOG4108WPU DNA polymerase III subunit psi BG574_02530 ENOG4105CIH Imidazole acetol-phosphate transaminase BG574_02535 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BG574_02545 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BG574_02560 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BG574_02565 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase BG574_02570 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BG574_02580 ENOG4105VEJ Heat shock protein BG574_02585 ENOG4107RK2 ADP-ribose diphosphatase NudE BG574_02590 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase BG574_02595 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BG574_02615 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BG574_02625 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BG574_02645 ENOG4107YB6 acetyltransferase, (GNAT) family BG574_02650 ENOG4105MYG DNA polymerase iii, chi subunit BG574_02655 ENOG4108WZM domain protein BG574_02660 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BG574_02690 ENOG4108J1Q BG574_02700 ENOG4108J1Q BG574_02705 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BG574_02710 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BG574_02740 ENOG4107S2Z UPF0761 membrane protein BG574_02745 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BG574_02750 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BG574_02755 ENOG4105CWM branched-chain amino acid transport system II carrier protein BG574_02760 ENOG4105CHR reductase BG574_02770 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BG574_02775 ENOG4105WPN DNA integration recombination invertion protein BG574_02780 ENOG4105EAH synthase BG574_02785 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BG574_02790 ENOG4105K46 50S ribosomal protein l27 BG574_02795 ENOG4105QYV Membrane BG574_02800 ENOG4105QYV Membrane BG574_02805 ENOG4108X4Q Hydrolase BG574_02810 ENOG4105MJ2 Competence protein BG574_02815 ENOG4105MGM doxx family BG574_02820 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BG574_02825 ENOG4105JAB phenazine biosynthesis protein, phzf family BG574_02830 ENOG4105DBV ornithine carbamoyltransferase BG574_02835 ENOG4108J1Q BG574_02845 ENOG4108RMU ferritin dps family protein BG574_02850 ENOG4105BZ4 penicillin-binding protein BG574_02855 ENOG4108IPT Naphthoate synthase BG574_02865 ENOG4108QD1 Membrane BG574_02875 ENOG4108J1Q BG574_02910 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BG574_02915 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BG574_02920 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BG574_02925 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BG574_02935 ENOG4105CPF Cell wall formation (By similarity) BG574_02945 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BG574_02950 ENOG4105CNI cell division protein FtsW BG574_02955 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BG574_02960 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BG574_02965 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) BG574_02970 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BG574_02975 ENOG4105CJN penicillin-binding protein BG574_02985 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BG574_03000 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BG574_03005 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BG574_03010 ENOG4105NXV High-affinity zinc uptake system protein BG574_03015 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BG574_03020 ENOG4105E7U AraC family transcriptional regulator BG574_03030 ENOG4105C03 ribonuclease BG574_03040 ENOG4108J1Q BG574_03045 ENOG4105K70 DNA-binding protein BG574_03050 ENOG4105R2J Conserved Protein BG574_03060 ENOG4105E07 UPF0149 protein BG574_03075 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BG574_03080 ENOG4105J4Q Transcriptional regulator BG574_03085 ENOG4105CK7 Sodium proline symporter BG574_03095 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BG574_03100 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) BG574_03105 ENOG41082RQ UPF0102 protein BG574_03110 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BG574_03115 ENOG4105W4M Transport-associated protein BG574_03130 ENOG4105CWC Acetylornithine deacetylase BG574_03140 ENOG4107VXZ Hydrolase BG574_03150 ENOG4105II7 pyrroline-5-carboxylate reductase BG574_03155 ENOG4105D8G Major Facilitator superfamily BG574_03165 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) BG574_03170 ENOG4105CN1 protease BG574_03175 ENOG4105DIT ErfK YbiS YcfS YnhG family protein BG574_03180 ENOG4105EAQ (twin-arginine translocation) pathway signal BG574_03185 ENOG4105C5X domain protein BG574_03195 ENOG4105K59 histidine triad (HIT) protein BG574_03205 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BG574_03210 ENOG4105ETT transcriptional Regulator, LysR family BG574_03215 ENOG4105PAD Hydrolase BG574_03220 ENOG4107R11 Transcriptional regulator BG574_03230 ENOG4105HDK L-asparaginase BG574_03240 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) BG574_03245 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BG574_03250 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BG574_03255 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BG574_03260 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BG574_03265 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BG574_03270 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) BG574_03275 ENOG41062MS nucleotidyltransferase substrate binding protein BG574_03280 ENOG41060A7 DNA polymerase beta domain protein region BG574_03285 ENOG4105CJ2 (LipO)protein BG574_03300 ENOG4108J1Q BG574_03320 ENOG4105CH7 arginosuccinase BG574_03325 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) BG574_03330 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BG574_03340 ENOG4105N21 Membrane BG574_03345 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BG574_03350 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BG574_03355 ENOG4105BZ1 (ABC) transporter BG574_03360 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BG574_03365 ENOG4105DY2 Paraquat-inducible protein b BG574_03370 ENOG41090R7 Ferric uptake BG574_03375 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) BG574_03380 ENOG4105NNH LexA regulated protein BG574_03385 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BG574_03390 ENOG4105C7N Xanthine uracil vitamin C permease BG574_03395 ENOG41090EX DsrE family BG574_03400 ENOG4105CBX hi0933 family BG574_03405 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BG574_03410 ENOG41062Z9 Membrane BG574_03415 ENOG4105EAC phosphoserine phosphatase BG574_03420 ENOG4108VPT UPF0234 protein BG574_03440 ENOG4105ECP epimerase BG574_03445 ENOG4105C4R Atp-dependent dna helicase BG574_03470 ENOG4105E2X shikimate dehydrogenase BG574_03475 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BG574_03480 ENOG4108WI1 Dna topoisomerase BG574_03485 ENOG41060QA UPF0267 protein BG574_03490 ENOG4105Y3E Modulates RecA activity (By similarity) BG574_03495 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BG574_03505 ENOG4105CRQ synthase (Component I) BG574_03510 ENOG4105CGY Dna recombination protein BG574_03510 ENOG4105CGY Dna recombination protein BG574_03515 ENOG4105DDQ anthranilate synthase BG574_03525 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BG574_03530 ENOG41063JG Transcriptional regulator BG574_03540 ENOG4105C5I Dehydrogenase BG574_03545 ENOG4105D60 lipoprotein releasing system transmembrane protein BG574_03550 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BG574_03555 ENOG4105D60 lipoprotein releasing system transmembrane protein BG574_03575 ENOG4105HS1 biotin--protein ligase BG574_03580 ENOG4105EYA deoxyribonuclease BG574_03590 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BG574_03600 ENOG4105EIB trna rrna methyltransferase BG574_03605 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BG574_03625 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BG574_03645 ENOG4107H6E BG574_03670 ENOG4105H40 BG574_03675 ENOG4108UUM single-stranded DNA-binding protein BG574_03705 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin BG574_03710 ENOG41063XI Toxic component of a toxin-antitoxin (TA) module. A BG574_03755 ENOG4108MXB Protein of unknown function (DUF968) BG574_03790 ENOG4105NVB glycoside hydrolase, family 19 BG574_03830 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BG574_03905 ENOG4108J1Q BG574_03925 ENOG4108J1Q BG574_03945 ENOG4108V3E phosphoribosylglycinamide formyltransferase BG574_03950 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BG574_03955 ENOG4105EHG Permease protein BG574_03975 ENOG4108JQ5 ABC transporter BG574_03980 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG574_03985 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BG574_03990 ENOG4105D38 putrescine abc transporter BG574_03995 ENOG4105F38 ABC transporter, permease BG574_04000 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BG574_04005 ENOG4105C4R Atp-dependent dna helicase BG574_04010 ENOG4108IJ0 Aspartate ammonia-lyase BG574_04015 ENOG410696E Membrane BG574_04020 ENOG4105CXB phosphoribosylaminoimidazole synthetase BG574_04030 ENOG4107UWN reductase BG574_04035 ENOG4105XW2 UPF0263 protein BG574_04040 ENOG4106H78 methyltransferase BG574_04045 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BG574_04050 ENOG4105CAK Cell division ATP-binding protein ftsE BG574_04055 ENOG4105CRP Part of the ABC transporter FtsEX involved in BG574_04070 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BG574_04080 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN BG574_04085 ENOG4108IUZ ABC transporter BG574_04090 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA BG574_04095 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) BG574_04100 ENOG4105CGK Exodeoxyribonuclease III BG574_04105 ENOG4105D3Y Na H antiporter BG574_04110 ENOG4105D0C transport protein BG574_04115 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) BG574_04120 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BG574_04125 ENOG41061ZR Transcriptional regulator BG574_04130 ENOG4107T9C Alpha amylase catalytic region BG574_04135 ENOG4105EG2 ABC transporter, permease BG574_04140 ENOG4105D56 permease protein BG574_04145 ENOG4107FKK extracellular solute-binding protein family 1 BG574_04150 ENOG4108IJ9 (ABC) transporter BG574_04155 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) BG574_04160 ENOG4107W52 maltose operon periplasmic protein BG574_04165 ENOG4105CKD glutathione-regulated potassium-efflux system protein BG574_04170 ENOG4107T0K Adenylate cyclase BG574_04175 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BG574_04190 ENOG4105K3M )-transporter BG574_04195 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BG574_04215 ENOG4105M15 transport protein ExbD BG574_04220 ENOG4105M8K biopolymer transport protein BG574_04230 ENOG4107QR8 Thioredoxin BG574_04235 ENOG4105VDH Dihydroxyacetone kinase BG574_04240 ENOG4108UTZ Dihydroxyacetone kinase BG574_04245 ENOG4105CMT Dihydroxyacetone kinase BG574_04250 ENOG4105C3M thioredoxin reductase BG574_04260 ENOG4105VP5 Bacterial protein of unknown function (DUF937) BG574_04270 ENOG4105DP9 ABC transporter BG574_04275 ENOG4105SVQ Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression (By similarity) BG574_04280 ENOG4105DJ0 Poly(A) Polymerase BG574_04285 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BG574_04295 ENOG4107H52 Dicarboxylate transport BG574_04310 ENOG4108UYE Lactoylglutathione lyase BG574_04315 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) BG574_04325 ENOG4108MVK Receptor BG574_04330 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) BG574_04335 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BG574_04340 ENOG4108BY2 phosphohistidine phosphatase BG574_04345 ENOG4105CA9 Pyruvate kinase BG574_04350 ENOG4105DKP glycosyl transferase, family 9 BG574_04355 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BG574_04360 ENOG4105EHE chorismate mutase- prephenate dehydrogenase BG574_04370 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BG574_04375 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BG574_04380 ENOG4105M2J Glutaredoxin BG574_04385 ENOG4105CM2 brancheD-chain amino acid aminotransferase BG574_04395 ENOG4105M4H endoribonuclease L-psp BG574_04400 ENOG4108IQE Amp-dependent synthetase and ligase BG574_04405 ENOG4108BPE -transporting atpase BG574_04410 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) BG574_04415 ENOG4105E5Z arginine transporter ATP-binding subunit BG574_04420 ENOG4106PMH Extracellular solute-binding protein family 3 BG574_04425 ENOG4105GBT ABC transporter BG574_04430 ENOG4105DMR ABC, transporter BG574_04440 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BG574_04445 ENOG4105CCF Lysine exporter protein (Lyse ygga) BG574_04450 ENOG4108ZAI phosphatidylglycerophosphatase a BG574_04455 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BG574_04460 ENOG4107YIM Involved in the transcription termination process (By similarity) BG574_04465 ENOG4105E4G Type IV pilus BG574_04490 ENOG4108JQC penicillin-binding protein 1A BG574_04495 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BG574_04500 ENOG4105D49 3-dehydroquinate synthase BG574_04505 ENOG4105DFE Dna adenine methylase BG574_04510 ENOG4105C8J )-transporter BG574_04515 ENOG4105BZA Phosphoglycerate kinase BG574_04520 ENOG4105D2N Aldolase BG574_04530 ENOG4108TVJ Nitroreductase BG574_04535 ENOG4108TEB UPF0114 protein BG574_04540 ENOG4105DC8 reductase BG574_04550 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) BG574_04555 ENOG4108MG3 formate dehydrogenase BG574_04560 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BG574_04565 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BG574_04570 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BG574_04575 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BG574_04585 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BG574_04590 ENOG4105C8N cysteinyl-tRNA synthetase BG574_04595 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BG574_04600 ENOG4105CFH Aspartokinase BG574_04610 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BG574_04615 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BG574_04620 ENOG4107QYX exodeoxyribonuclease v alpha BG574_04650 ENOG4107QP8 phosphohexose isomerase BG574_04655 ENOG4105W0Z cytoplasmic protein BG574_04660 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BG574_04665 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BG574_04670 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BG574_04690 ENOG4105E4F Isochorismate synthase BG574_04695 ENOG4105CHM Aminotransferase BG574_04705 ENOG4105N14 lysine exporter protein LysE YggA BG574_04710 ENOG4105C25 Primosomal protein n' BG574_04715 ENOG41080C8 DUF218 domain BG574_04725 ENOG4105D2T synthase BG574_04740 ENOG4108MY6 biosynthesis protein BG574_04745 ENOG4105P7J Transfers sialic acid from the substrate CMP-sialic acid donor to the terminal beta-D-galactosyl-1,4-acetyl-beta-D- glucosamine on the lacto-N-neotetraose branch of the lipooligosaccharide BG574_04750 ENOG41068D6 Glycosyltransferase BG574_04760 ENOG4108RJ9 Glycosyl transferase, family 2 BG574_04765 ENOG4108RYC glycosyltransferase BG574_04770 ENOG4105E0X reductase BG574_04775 ENOG4105D9N nucleoside BG574_04785 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BG574_04790 ENOG4105CF7 AraC family transcriptional regulator BG574_04795 ENOG4108ZHJ Organic hydroperoxide resistance protein BG574_04805 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BG574_04815 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BG574_04825 ENOG4105C8Y Acetylornithine aminotransferase BG574_04830 ENOG4108EQA pts system BG574_04835 ENOG4108IQ3 PTS system BG574_04840 ENOG4105ETZ PTS System BG574_04845 ENOG4105F3R pts system mannose fructose sorbose family iid BG574_04855 ENOG4105D6F Phosphatase BG574_04860 ENOG4105EMD TRANSCRIPTIONal BG574_04875 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BG574_04880 ENOG4105C6T cysteine synthase BG574_04885 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BG574_04895 ENOG4108M8S permease YjgP YjgQ family protein BG574_04900 ENOG4108K5H permease YjgP YjgQ family protein BG574_04905 ENOG4105C0B DNA polymerase III (alpha subunit) BG574_04915 ENOG4105CFP Peptidase U32 BG574_04920 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase BG574_04925 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BG574_04930 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) BG574_04935 ENOG4105K8N protein family UPF0079, ATPase BG574_04940 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BG574_04945 ENOG4108J1Q BG574_04950 ENOG4105D5Q Arginine ornithine antiporter BG574_04960 ENOG4108EKI Dehydrogenase BG574_04965 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BG574_04970 ENOG41076E6 Uroporphyrinogen-III Synthase BG574_04975 ENOG4105ECF c-methyltransferase BG574_04980 ENOG410601J HemY protein BG574_04985 ENOG4105CKW Inner membrane protein yedI BG574_04990 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BG574_04995 ENOG4105EIN peptidylprolyl cis-trans isomerase BG574_05000 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BG574_05005 ENOG4107QSI ABC, transporter BG574_05010 ENOG4105D1F ATP-binding protein BG574_05015 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) BG574_05020 ENOG4105EUJ GTP cyclohydrolase i BG574_05030 ENOG4105C59 p-type ATPase BG574_05035 ENOG4105C59 p-type ATPase BG574_05040 ENOG4108Z6Z Transcriptional regulator BG574_05045 ENOG4108J1Q BG574_05065 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BG574_05070 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BG574_05075 ENOG4107ZVW dihydroneopterin aldolase BG574_05085 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) BG574_05090 ENOG4105C8P )-transporter BG574_05095 ENOG4105C8P )-transporter BG574_05105 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BG574_05110 ENOG4105EIF outer membrane protein W BG574_05120 ENOG4105K63 Thioredoxin BG574_05130 ENOG4107QJR hflk protein BG574_05135 ENOG4105EPW hflc protein BG574_05155 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BG574_05160 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BG574_05165 ENOG4108VTV Inherit from NOG: Membrane BG574_05170 ENOG4105CTQ phosphohexokinase BG574_05175 ENOG4105C9B Cysteine desulfurase BG574_05230 ENOG4108MBX Secretion Protein BG574_05240 ENOG4105KK6 nuclease BG574_05245 ENOG4105BZG amino acid carrier protein BG574_05250 ENOG4105DSF transport protein BG574_05255 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BG574_05260 ENOG4108UJU UPF0301 protein BG574_05265 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BG574_05280 ENOG4105M85 Bola protein BG574_05310 ENOG4105M6F mutator MutT protein BG574_05315 ENOG4108J1Q BG574_05340 ENOG4105C4M (Ubiquinol oxidase) subunit I BG574_05345 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BG574_05355 ENOG4107YD3 Thioesterase BG574_05360 ENOG4105E02 MotA TolQ exbB proton channel BG574_05375 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) BG574_05380 ENOG4105KCK Peptidoglycan-associated lipoprotein BG574_05390 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) BG574_05400 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) BG574_05405 ENOG4106K28 UPF0283 membrane protein BG574_05415 ENOG4108W1A pseudouridine synthase BG574_05430 ENOG4105C5H ABC transporter BG574_05440 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BG574_05445 ENOG4105CVM Molybdenum cofactor synthesis domain protein BG574_05450 ENOG4105D06 uba thif-type nad fad binding protein BG574_05460 ENOG4105PQ6 UPF0208 membrane protein BG574_05470 ENOG4107835 probably involved in intracellular septation (By similarity) BG574_05475 ENOG4105NAU thioesterase Superfamily protein BG574_05480 ENOG4105K9H YciI-like protein BG574_05485 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BG574_05490 ENOG4105DZR Type I site-specific deoxyribonuclease BG574_05500 ENOG4105EKX Restriction modification system DNA (Specificity BG574_05505 ENOG4105CVR type I restriction-modification system BG574_05515 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) BG574_05520 ENOG4105XCT Protein of unknown function (DUF2489) BG574_05525 ENOG4105D4P Coproporphyrinogen iii oxidase BG574_05530 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) BG574_05535 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BG574_05545 ENOG4105N16 Protein of unknown function (DUF2877) BG574_05555 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BG574_05565 ENOG4105S0E allantoin catabolism protein BG574_05570 ENOG4105DG4 malate L-lactate dehydrogenase BG574_05575 ENOG4107REC cytoplasmic protein BG574_05580 ENOG4105C5B carbamate kinase BG574_05585 ENOG4105DAA L-lactate BG574_05595 ENOG4105CE7 Amidase, hydantoinase carbamoylase family BG574_05600 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) BG574_05610 ENOG4108WQI RNA Polymerase BG574_05620 ENOG4105E18 UPF0276 protein BG574_05630 ENOG4109045 doxx family BG574_05645 ENOG4105C5R Aminotransferase BG574_05650 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BG574_05655 ENOG4105C3F Signal peptidase i BG574_05665 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BG574_05670 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) BG574_05675 ENOG4105C1J atp-dependent rna helicase BG574_05680 ENOG4105D7A ATP-binding protein BG574_05685 ENOG4107ZXU DSBA oxidoreductase BG574_05690 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BG574_05700 ENOG4107QKW extracellular solute-binding protein family 1 BG574_05710 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BG574_05715 ENOG4108I6E Sulfatase BG574_05720 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BG574_05725 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BG574_05730 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BG574_05735 ENOG41063SB peptidase BG574_05745 ENOG4105CFU surface antigen BG574_05750 ENOG4105MA0 exported protein BG574_05755 ENOG4108JJ9 ABC, transporter BG574_05760 ENOG4108JJ8 (ABC) transporter BG574_05765 ENOG41075W9 High frequency lysogenization protein HflD homolog BG574_05770 ENOG4107QTF adenylosuccinate lyase BG574_05775 ENOG4105E98 transcriptional regulator DeoR family BG574_05780 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) BG574_05800 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BG574_05805 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BG574_05810 ENOG4105DDY UPF0142 protein ycaO BG574_05830 ENOG4105FB9 CRISPR-associated protein BG574_05855 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) BG574_05865 ENOG4105C03 ribonuclease BG574_05870 ENOG4105CRK lysyL-tRNA synthetase BG574_05875 ENOG4105DWV Homoserine O-trans-acetylase BG574_05880 ENOG4107GZ4 SanA protein BG574_05885 ENOG4105CIY formyltetrahydrofolate deformylase BG574_05890 ENOG4108SAU DNA-binding protein H-ns BG574_05895 ENOG4107S6Z Na H antiporter BG574_05900 ENOG4105EMU Dehydrogenase BG574_05910 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BG574_05915 ENOG4106J39 exported protein BG574_05920 ENOG4105C2M dna polymerase I BG574_05925 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) BG574_05935 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase BG574_05950 ENOG4105C6K Malic enzyme BG574_05965 ENOG41065CD Exported protein BG574_05970 ENOG4105D7X high-affinity nickel-transporter BG574_05975 ENOG4105BZG amino acid carrier protein BG574_05980 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BG574_05985 ENOG4105CMV Succinyl-CoA synthetase subunit beta BG574_05990 ENOG4105C7S Dehydrogenase BG574_05995 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BG574_06000 ENOG4105FDK ABC transporter BG574_06005 ENOG4105DR5 peptidase BG574_06010 ENOG4105T95 Thiol disulfide interChange protein BG574_06015 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BG574_06025 ENOG4108K4B hydrolase BG574_06030 ENOG4105BZU Histidine kinase BG574_06040 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BG574_06045 ENOG4105K8R UPF0145 protein BG574_06050 ENOG4108ZZ3 UPF0260 protein BG574_06055 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BG574_06060 ENOG4108JU8 Transcriptional regulator BG574_06065 ENOG4108EVY peptide transport periplasmic protein BG574_06075 ENOG4108EU3 peptide transport system, permease BG574_06080 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein BG574_06095 ENOG4105E0X reductase BG574_06100 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BG574_06110 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BG574_06125 ENOG4105QYK bacteriophage lambda Bor protein homolog BG574_06130 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BG574_06135 ENOG4105DS0 Transcriptional regulator, Crp Fnr family BG574_06150 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BG574_06155 ENOG4108J3C UTP-glucose-1-phosphate uridylyltransferase BG574_06165 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) BG574_06175 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) BG574_06180 ENOG4105F27 Major Facilitator BG574_06185 ENOG4105E68 Sulfatase BG574_06190 ENOG4105PAN UPF0352 protein BG574_06195 ENOG4105Y7M Transcriptional regulator, TetR family BG574_06200 ENOG410624X efflux transporter, rnd family, mfp subunit BG574_06205 ENOG4105BZS acriflavin resistance protein BG574_06210 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BG574_06215 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 BG574_06225 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BG574_06230 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III BG574_06235 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BG574_06240 ENOG4108UJD 30S ribosomal protein S9 BG574_06245 ENOG4105D1Q UPF0246 protein BG574_06260 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein BG574_06270 ENOG4108RCM Nitroreductase BG574_06280 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BG574_06285 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BG574_06290 ENOG4108QBX (LipO)protein BG574_06295 ENOG4105C0H protease BG574_06300 ENOG4105CAT Cytidine monophosphate kinase BG574_06305 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BG574_06310 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BG574_06315 ENOG4105Q4A inner membrane protein yciS BG574_06320 ENOG4105CFV Tetratricopeptide repeat protein BG574_06325 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BG574_06330 ENOG4108ZJT translation initiation factor, Sui1 BG574_06335 ENOG4107SC1 transglycosylase BG574_06350 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BG574_06355 ENOG4105CHV Transcription elongation factor NusA BG574_06360 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BG574_06365 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BG574_06370 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BG574_06375 ENOG4105CVE Lytic murein transglycosylase BG574_06380 ENOG4108Z6B deaminase BG574_06385 ENOG4105C1J atp-dependent rna helicase BG574_06390 ENOG4105RT1 May be involved in cell division (By similarity) BG574_06395 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BG574_06400 ENOG4105BZU Histidine kinase BG574_06405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG574_06410 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BG574_06415 ENOG4105E2Z phosphate ABC transporter (Permease BG574_06420 ENOG4105C8U phosphate abc transporter BG574_06425 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) BG574_06430 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BG574_06435 ENOG4105CFH Aspartokinase BG574_06440 ENOG4105CI1 PTS System BG574_06445 ENOG41090HJ UPF0265 protein BG574_06450 ENOG4105C9X ppx gppa phosphatase BG574_06455 ENOG4108R66 Conserved Protein BG574_06460 ENOG4105QEK Transcriptional regulator BG574_06465 ENOG4108J1Q BG574_06470 ENOG4105CGH 5'-nucleotidase BG574_06475 ENOG41080IJ Diacylglycerol kinase BG574_06480 ENOG4108IYC Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) BG574_06485 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 BG574_06500 ENOG4105D5K Hemolysin activator protein BG574_06505 ENOG4105CKT filamentous hemagglutinin BG574_06545 ENOG4105UGU tonB-dependent Receptor BG574_06555 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BG574_06560 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BG574_06565 ENOG4107QNR UPF0135 protein BG574_06570 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BG574_06580 ENOG4105DXN mazG family BG574_06590 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BG574_06595 ENOG4105CGF Aromatic amino acid aminotransferase BG574_06605 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BG574_06610 ENOG4108ZAF Molybdopterin BG574_06615 ENOG4105M00 molybdopterin converting factor, subunit 1 BG574_06620 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BG574_06630 ENOG41061ZR Transcriptional regulator BG574_06635 ENOG4105CUW cytochrome C-TYPE protein BG574_06640 ENOG4107QY8 reductase BG574_06655 ENOG4108J1Q BG574_06665 ENOG4105BZN citrate synthase BG574_06670 ENOG4108HMX isocitrate dehydrogenase (NADP) BG574_06675 ENOG4107QIJ Aconitate hydratase 2 BG574_06680 ENOG4107QY8 reductase BG574_06690 ENOG4105M08 Membrane BG574_06710 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BG574_06715 ENOG4105C28 cystathionine BG574_06745 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BG574_06755 ENOG4108DNC Involved in acetate metabolism (By similarity) BG574_06760 ENOG41077A9 carbonic anhydrase BG574_06765 ENOG4105C7K acetolactate synthase BG574_06770 ENOG4108ZP8 Acetolactate synthase small subunit BG574_06775 ENOG4108SXK Transporter Drug Metabolite Exporter family BG574_06780 ENOG4107QZM n-acetylglutamate synthase BG574_06785 ENOG4107EPN Domain of unknown function (DUF1508) BG574_06790 ENOG4107RAQ aminopeptidase BG574_06795 ENOG4107A4G HTH_XRE BG574_06800 ENOG4105CBT Fructose-1,6-bisphosphatase BG574_06810 ENOG4107104 thymidine kinase BG574_06815 ENOG4105C4X radical SAM domain protein BG574_06825 ENOG4107RUZ Sss sodium solute transporter superfamily BG574_06840 ENOG41072GX Peptidase M22 Glycoprotease BG574_06845 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BG574_06850 ENOG4105CGZ zinc metallopeptidase BG574_06855 ENOG4105CNU cell division protein FtsK BG574_06860 ENOG4105EW9 transcriptional regulator AsnC family BG574_06865 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) BG574_06870 ENOG4105E2R ROK family BG574_06875 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BG574_06880 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system BG574_06885 ENOG4105DVA methyltransferase BG574_06895 ENOG4105CHW UPF0052 protein BG574_06900 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BG574_06905 ENOG4105CC0 LysR family Transcriptional regulator BG574_06920 ENOG4105KB2 stringent starvation protein b BG574_06925 ENOG4107MKT Stringent starvation protein a BG574_06930 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BG574_06935 ENOG4105HDK L-asparaginase BG574_06940 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BG574_06950 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BG574_06965 ENOG4105DBE peroxidase BG574_06975 ENOG4105DB7 PHP domain protein BG574_06985 ENOG4105CJB Exodeoxyribonuclease I BG574_06990 ENOG4105C5S asparaginyl-tRNA synthetase BG574_06995 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BG574_07005 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BG574_07010 ENOG4105EQ2 LysR family Transcriptional regulator BG574_07025 ENOG4105CX6 glutaminyL-tRNA synthetase BG574_07035 ENOG4105CXY transporter BG574_07040 ENOG4105F0Z galactose-1-phosphate uridylyltransferase BG574_07045 ENOG4105EAA nucleoside BG574_07050 ENOG4105ETE Transcriptional regulator (LacI family BG574_07055 ENOG4107R37 Glutamate dehydrogenase BG574_07060 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BG574_07070 ENOG4105KME endoribonuclease L-psp BG574_07075 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BG574_07105 ENOG4108UGV hypoxanthine phosphoribosyltransferase BG574_07110 ENOG4105CMS peptidase U62, modulator of DNA gyrase BG574_07115 ENOG4105N42 UPF0307 protein BG574_07125 ENOG4108UQV Membrane BG574_07130 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BG574_07135 ENOG4108ZPB UPF0306 protein BG574_07165 ENOG4105NSG hemerythrin hhe cation binding domain protein BG574_07170 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BG574_07180 ENOG4105VEQ Cold shock protein BG574_07185 ENOG4108P11 EamA-like transporter family BG574_07205 ENOG4105CNN ABC, transporter BG574_07210 ENOG4105CNN ABC, transporter BG574_07215 ENOG4105CMG Carbohydrate kinase BG574_07220 ENOG41066VF YeeE YedE family protein BG574_07225 ENOG4105KSU Redox protein BG574_07255 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BG574_07260 ENOG4105VNG YcgL domain-containing protein BG574_07265 ENOG4105CDU Replicative dna helicase BG574_07275 ENOG4105DHS permease protein BG574_07280 ENOG4105CM4 permease protein BG574_07285 ENOG4108IPW abc transporter atp-binding protein BG574_07290 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) BG574_07300 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BG574_07305 ENOG4107IX6 phosphate transport regulator BG574_07310 ENOG4105CJ3 phosphate transporter BG574_07320 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BG574_07335 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BG574_07340 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) BG574_07350 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BG574_07375 ENOG4107QN2 dihydrolipoyl dehydrogenase BG574_07380 ENOG4107QSN dihydrolipoamide acetyltransferase BG574_07385 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BG574_07390 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) BG574_07395 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BG574_07410 ENOG4105BZ1 (ABC) transporter BG574_07415 ENOG41067MG lrgb family BG574_07420 ENOG4105VAW lrga family BG574_07425 ENOG4105DVT helicase BG574_07435 ENOG4108JJB ABC transporter BG574_07445 ENOG4105CHH sulfate transporter BG574_07450 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BG574_07455 ENOG4108UUM single-stranded DNA-binding protein BG574_07470 ENOG4108J1Q BG574_07475 ENOG4105DSB aldose 1-epimerase BG574_07485 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b BG574_07495 ENOG4108Z33 Thiol disulfide Interchange Protein BG574_07500 ENOG4105DEN Luciferase family BG574_07505 ENOG4105KZW UPF0381 protein BG574_07510 ENOG4108J1Q BG574_07530 ENOG4105CDU Replicative dna helicase BG574_07555 ENOG4105CA3 membrane-bound lytic murein transglycosylase BG574_07565 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase BG574_07570 ENOG4105E96 Colicin v production protein BG574_07575 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BG574_07585 ENOG4105M5K heptosyltransferase BG574_07590 ENOG4106WTF Glycosyl transferase, family 2 BG574_07595 ENOG4105HBR Rna-binding protein BG574_07600 ENOG4105EYK Phosphatidylglycerophosphatase B BG574_07615 ENOG4105E0M Sulfatase BG574_07620 ENOG4105QVC MOSC domain-containing protein BG574_07630 ENOG4105CTB Polyprenyl synthetase BG574_07635 ENOG4105E7A Glutamine amidotransferase BG574_07645 ENOG4105FAV ABC, transporter BG574_07650 ENOG4105D1H recombination factor protein RarA BG574_07660 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BG574_07665 ENOG4105DFF Rod shape-determining protein mreb BG574_07670 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BG574_07675 ENOG4105DBI uridine monophosphokinase BG574_07680 ENOG4105DHP deoxycytidine triphosphate deaminase BG574_07690 ENOG4108VD1 dedA family BG574_07700 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) BG574_07705 ENOG4105EV9 Alpha Beta Hydrolase BG574_07710 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) BG574_07715 ENOG4105CEY Amp-dependent synthetase and ligase BG574_07720 ENOG4105EGS Mechanosensitive ion channel BG574_07730 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) BG574_07735 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BG574_07750 ENOG4105DFP Integrase BG574_07755 ENOG4105DFP Integrase BG574_07820 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BG574_07825 ENOG4105DZ2 Transcriptional regulator BG574_07830 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BG574_07835 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BG574_07840 ENOG4105CVS RNA methyltransferase TrmH family, group 1 BG574_07845 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BG574_07850 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BG574_07855 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BG574_07860 ENOG4108ESZ Glycogen debranching enzyme BG574_07870 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein BG574_07875 ENOG4105DE4 1-phosphofructokinase BG574_07880 ENOG4105DM4 PTS System BG574_07890 ENOG4105DTR rard protein BG574_07895 ENOG4108V0P LemA family BG574_07920 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) BG574_07925 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BG574_07930 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BG574_07940 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BG574_07945 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BG574_07950 ENOG4105KNE Phosphatidate cytidylyltransferase BG574_07955 ENOG4105DZP Membrane-associated zinc metalloprotease BG574_07960 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BG574_07970 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BG574_07975 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BG574_07980 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BG574_07985 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) BG574_07990 ENOG4105DK0 Indole-3-glycerol phosphate synthase BG574_07995 ENOG4105WP7 tRNA pseudouridine synthase C BG574_08000 ENOG4105DR9 pseudouridine synthase BG574_08010 ENOG4105I7R Adenylate cyclase BG574_08015 ENOG4105CM6 amino acid regulated cytosolic protein BG574_08030 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BG574_08050 ENOG4105C8T Leucyl-tRNA synthetase BG574_08060 ENOG4105DJF DNA polymerase III, delta' subunit BG574_08065 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) BG574_08080 ENOG4105D7Q type ii secretion system BG574_08085 ENOG4107QHF type ii secretion system protein e BG574_08095 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BG574_08105 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BG574_08110 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BG574_08115 ENOG4105EJ9 Membrane BG574_08120 ENOG4105CSM endonuclease III BG574_08125 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BG574_08135 ENOG4105WVQ Fe-S assembly protein IscX BG574_08140 ENOG4108ZIT Ferredoxin, 2FE-2S BG574_08155 ENOG4105WDY DNA (cytosine-5-)-methyltransferase BG574_08160 ENOG4108RF1 Protein of unknown function DUF2625 BG574_08165 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) BG574_08170 ENOG4108Z4V iron-sulfur cluster assembly BG574_08175 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins BG574_08180 ENOG4105C3J Cysteine desulfurase BG574_08185 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family BG574_08190 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation BG574_08195 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BG574_08200 ENOG4105BZU Histidine kinase BG574_08210 ENOG4108TZV Membrane BG574_08220 ENOG4108KXH Ybak prolyl-tRNA synthetase associated BG574_08225 ENOG4108DG9 Smr protein MutS2 BG574_08230 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) BG574_08235 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BG574_08250 ENOG4108J1Q BG574_08260 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BG574_08265 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BG574_08270 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BG574_08275 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BG574_08285 ENOG4105CSA Coproporphyrinogen iii oxidase BG574_08290 ENOG4107QSI ABC, transporter BG574_08305 ENOG4108JQ6 ABC transporter BG574_08310 ENOG4108IYU L-aspartate oxidase BG574_08315 ENOG4105DFD Na H antiporter BG574_08320 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BG574_08325 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BG574_08335 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BG574_08340 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) BG574_08345 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BG574_08350 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) BG574_08355 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BG574_08360 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BG574_08365 ENOG4105CEY Amp-dependent synthetase and ligase BG574_08375 ENOG4105VQK sigma E regulatory protein, MucB RseB BG574_08380 ENOG41069PW sigma-e factor negative regulatory protein BG574_08385 ENOG4105EMN RNA polymerase sigma factor BG574_08395 ENOG4105DQF Hydrolase BG574_08400 ENOG4105DJY efflux transporter, rnd family, mfp subunit BG574_08405 ENOG4105C09 Bile acid BG574_08410 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BG574_08420 ENOG4108RRZ Transcription elongation factor GreB BG574_08425 ENOG4107QKA exodeoxyribonuclease V beta BG574_08430 ENOG4107QI1 Mate efflux family protein BG574_08435 ENOG4107RUE extracellular solute-binding protein family 1 BG574_08450 ENOG4108VMM UPF0756 membrane protein BG574_08455 ENOG4105CQ7 ATP-dependent helicase BG574_08470 ENOG4107QX8 SPFH domain, Band 7 family protein BG574_08475 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BG574_08480 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) BG574_08490 ENOG4107TT5 NLP P60 protein BG574_08500 ENOG4107XHZ cytoplasmic chaperone TorD family protein BG574_08510 ENOG4108J1Q BG574_08515 ENOG4108Q67 UPF0319 protein BG574_08520 ENOG4108JU5 Magnesium and cobalt efflux protein BG574_08525 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) BG574_08540 ENOG4108R6K riboflavin synthase, subunit alpha BG574_08545 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BG574_08550 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BG574_08555 ENOG4105EMY transcriptional regulator BG574_08575 ENOG4105CV1 Transketolase (EC 2.2.1.1) BG574_08580 ENOG4105C9A Phoh family BG574_08595 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) BG574_08600 ENOG4105C28 cystathionine BG574_08610 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BG574_08615 ENOG4105D6S protein involved in catabolism of external DNA BG574_08620 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase BG574_08625 ENOG4105D3G Pseudouridine synthase BG574_08650 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein BG574_08655 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BG574_08660 ENOG4105C2C drug resistance transporter, Bcr CflA BG574_08665 ENOG4105I08 Pseudouridine synthase BG574_08670 ENOG4105DNI Converts SHCHC to OSB (By similarity) BG574_08675 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BG574_08685 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BG574_08690 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase BG574_08700 ENOG4105DC1 bifunctional purine biosynthesis protein purh BG574_08705 ENOG4105EJQ L-serine dehydratase BG574_08710 ENOG4105C44 Serine transporter BG574_08715 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BG574_08720 ENOG4105D1S lipid A biosynthesis BG574_08725 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA BG574_08735 ENOG4105C34 Pseudouridine synthase BG574_08740 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BG574_08745 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BG574_08750 ENOG4107J0A lipopolysaccharide biosynthetic process BG574_08755 ENOG4105XQ6 frataxin-like protein BG574_08760 ENOG4105C9U ATP-dependent DNA helicase RecQ BG574_08765 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BG574_08770 ENOG41082NX 50s ribosomal protein l35 BG574_08775 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BG574_08790 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BG574_08795 ENOG4108MN8 Membrane BG574_08800 ENOG4108Z0T Part of a sulfur-relay system (By similarity) BG574_08815 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BG574_08820 ENOG4108KBJ Inner membrane protein YkgB BG574_08825 ENOG4105K8Z Phage shock protein BG574_08835 ENOG4108J1Q BG574_08840 ENOG4105E7U AraC family transcriptional regulator BG574_08845 ENOG4106HK8 GPR1 FUN34 yaaH family protein BG574_08865 ENOG4105EE5 Membrane protein terC BG574_08870 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) BG574_08875 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) BG574_08880 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BG574_08895 ENOG4108J1Q BG574_08900 ENOG4105CXG d-lactate dehydrogenase BG574_08930 ENOG4107H6E BG574_08955 ENOG41066EA baseplate J family protein BG574_09025 ENOG4105EFV Major head subunit BG574_09040 ENOG4107XYH virion morphogenesis protein BG574_09050 ENOG4105QIB mu-like prophage Flumu protein gp29 BG574_09060 ENOG4108J1Q BG574_09115 ENOG4106IKR BG574_09180 ENOG4108PNI recT protein BG574_09305 ENOG4105NVB glycoside hydrolase, family 19 BG574_09420 ENOG4108J1Q BG574_09475 ENOG4105XB7 anti-repressor protein BG574_09480 ENOG4105ZIA Phage protein gp16 BG574_09485 ENOG41065S5 BG574_09535 ENOG4108WTW DNA transposition protein BG574_09545 ENOG4105R8V Transcriptional regulator BG574_09550 ENOG4105M7P phage repressor BG574_09555 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BG574_09560 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) BG574_09570 ENOG4105C2W permease BG574_09575 ENOG4105D0A hydroxylase BG574_09585 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) BG574_09605 ENOG4108J1Q BG574_09615 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BG574_09640 ENOG4107RN3 metallophosphoesterase BG574_09645 ENOG4105NX3 Membrane BG574_09650 ENOG4105F0Z galactose-1-phosphate uridylyltransferase BG574_09655 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BG574_09660 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BG574_09665 ENOG4108UUE Transcriptional regulator BG574_09670 ENOG4105VIE preprotein translocase, subunit YajC BG574_09675 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BG574_09680 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BG574_09685 ENOG4105C7N Xanthine uracil vitamin C permease BG574_09700 ENOG4105C4Y ABC transporter BG574_09705 ENOG4105CEP NADH dehydrogenase BG574_09710 ENOG4105GPY SprT protein BG574_09715 ENOG41083KI ribonuclease, T2 BG574_09725 ENOG4108NRW Phospholipase, patatin family BG574_09735 ENOG4105D01 (LipO)protein BG574_09740 ENOG4105D01 (LipO)protein BG574_09745 ENOG4105D01 (LipO)protein BG574_09750 ENOG4108UMI ABC transporter, permease BG574_09755 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BG574_09760 ENOG4105CPB ATP-dependent endonuclease of the OLD family BG574_09765 ENOG4105EWT decarboxylase family BG574_09770 ENOG4105CUZ uba thif-type nad fad binding protein BG574_09775 ENOG4105C5H ABC transporter BG574_09790 ENOG41082EK Restriction modification system DNA (Specificity BG574_09800 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BG574_09810 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BG574_09820 ENOG4108ZXC Two component transcriptional regulator, luxr family BG574_09825 ENOG4106AFQ Histidine kinase BG574_09850 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BG574_09855 ENOG4106WHD Tetrathionate reductase BG574_09865 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein BG574_09870 ENOG4105ENJ RND efflux system, outer membrane lipoprotein BG574_09875 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BG574_09880 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) BG574_09895 ENOG4105CIN aminoacyl-histidine dipeptidase BG574_09900 ENOG4105D2S major facilitator superfamily BG574_09910 ENOG4108Z1B Cyclase dehydrase BG574_09915 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) BG574_09920 ENOG4105E0C molybdate abc transporter BG574_09925 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BG574_09930 ENOG4105E3A (ABC) transporter BG574_09935 ENOG4105DA5 (ABC) transporter BG574_09940 ENOG4107QMP dna polymerase iii subunits gamma and tau BG574_09945 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BG574_09950 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase BG574_09955 ENOG4105DZB Electron transport complex BG574_09965 ENOG4105D6A Electron transport complex BG574_09970 ENOG4105EN6 Membrane BG574_09975 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) BG574_09980 ENOG4108R3D Electron transport complex BG574_09985 ENOG4105DGN Electron transport complex BG574_10005 ENOG4105C5H ABC transporter BG574_10010 ENOG4107RZZ dna polymerase iii epsilon subunit BG574_10025 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) BG574_10035 ENOG4105C12 Phosphoribosylglycinamide synthetase BG574_10050 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) BG574_10055 ENOG4107XDY Nicotinamide Mononucleotide Transporter BG574_10070 ENOG4105FE9 pseudouridine synthase BG574_10075 ENOG4107RTD sua5 ycio yrdc ywlc family protein BG574_10080 ENOG4105CRQ synthase (Component I) BG574_10085 ENOG4105DDQ anthranilate synthase BG574_10090 ENOG4108V5Q transglutaminase-like protein BG574_10100 ENOG4105DMQ Methyltransferase BG574_10110 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) BG574_10115 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BG574_10120 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BG574_10125 ENOG4107R3N Filamentation induced by cAMP protein fic BG574_10145 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) BG574_10155 ENOG4105CMR udp-glucose 4-epimerase BG574_10165 ENOG4105SYT Methylenetetrahydrofolate reductase BG574_10185 ENOG4108U1V ABC transporter, permease BG574_10190 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BG574_10215 ENOG4105C3R Methionine synthase BG574_10220 ENOG4105EYM Major Facilitator superfamily BG574_10225 ENOG4105E0A ABC, transporter BG574_10240 ENOG4108J1Q BG574_10250 ENOG4105CNM Receptor BG574_10260 ENOG4108J1Q BG574_10265 ENOG4105RHG BG574_10270 ENOG4105Z2P Protein of unknown function (DUF465) BG574_10275 ENOG4105CQC Prephenate dehydratase BG574_10280 ENOG4105DGW oligopeptidase A BG574_10285 ENOG4105F1A Pyruvate formate-lyase BG574_10295 ENOG4105C6N Formate acetyltransferase BG574_10300 ENOG4105TMB Formate nitrite transporter BG574_10305 ENOG4105W39 Membrane BG574_10310 ENOG4105D0M Protease HtpX homolog BG574_10315 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BG574_10320 ENOG4105DWU Membrane BG574_10330 ENOG4108BMY protease BG574_10345 ENOG4108TIT dATP pyrophosphohydrolase BG574_10350 ENOG4105CDY transcriptional regulatory protein BG574_10360 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BG574_10365 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BG574_10370 ENOG4105VFK BolA family BG574_10380 ENOG4105E3I toluene tolerance BG574_10385 ENOG4107PE3 Mammalian cell entry related domain protein BG574_10390 ENOG4105CY3 ABC transporter, permease BG574_10395 ENOG4105DHJ ABC, transporter BG574_10400 ENOG4105C0H protease BG574_10410 ENOG4108DMF Cytochrome C biogenesis protein BG574_10415 ENOG4107QX9 Thiol disulfide interChange protein BG574_10420 ENOG4105DA4 cytochrome c-type biogenesis protein BG574_10425 ENOG4105DVI reductase, NrfD BG574_10430 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BG574_10435 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit BG574_10440 ENOG4105EAU Plays a role in nitrite reduction (By similarity) BG574_10450 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit BG574_10465 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BG574_10470 ENOG4105CSH Transporter BG574_10475 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BG574_10490 ENOG4105D07 Signal peptide peptidase, SppA BG574_10495 ENOG41069NU Nitroreductase BG574_10500 ENOG4105BZM domain protein BG574_10505 ENOG41090FY type IV pilus biogenesis stability protein PilW BG574_10530 ENOG4105DIK (ABC) transporter BG574_10535 ENOG4105CC5 ABC transporter BG574_10540 ENOG4105CC5 ABC transporter BG574_10545 ENOG4108535 NAD dependent epimerase/dehydratase family BG574_10570 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BG574_10575 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A BG574_10595 ENOG4108JA2 transcriptioN-repair coupling factor BG574_10600 ENOG4105E0U tyrosine-specific transport protein BG574_10620 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related BG574_10625 ENOG4105CD8 aminopeptidase N BG574_10630 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 BG574_10635 ENOG4108J59 Extracellular solute-binding protein, family 5 BG574_10660 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BG574_10670 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BG574_10685 ENOG4108R99 pseudouridine synthase BG574_10695 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 BG574_10700 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) BG574_10705 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) BG574_10715 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BG574_10765 ENOG4105P4J Allophanate hydrolase, subunit 1 BG574_10770 ENOG4107R7A Allophanate hydrolase subunit 2 BG574_10775 ENOG4105E7W lamb ycsf family protein BG574_10780 ENOG4105C5A transporter BG574_10785 ENOG4106AFN Lyase and sodium transporter (By similarity) BG574_10790 ENOG4107QSA Oxaloacetate decarboxylase BG574_10795 ENOG4105D9Q decarboxylase (Beta subunit) BG574_10800 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BG574_10810 ENOG4105CE4 GlcNAc 6-P deacetylase BG574_10815 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BG574_10825 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BG574_10835 ENOG4105WH1 Two component transcriptional regulator luxr family BG574_10840 ENOG4105ETE Transcriptional regulator (LacI family BG574_10845 ENOG4108RVA ribokinase BG574_10850 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BG574_10855 ENOG4105CNN ABC, transporter BG574_10865 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BG574_10870 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding BG574_10875 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) BG574_10880 ENOG4105DSJ YicC domain protein BG574_10885 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BG574_10890 ENOG4105UGU tonB-dependent Receptor BG574_10895 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BG574_10900 ENOG4107QR9 Iron-sulfur cluster binding protein BG574_10905 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BG574_10910 ENOG4105DAA L-lactate BG574_10915 ENOG4105C3G gtp-binding protein BG574_10920 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BG574_10925 ENOG41061WM D-Alanyl-D-Alanine BG574_10935 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BG574_10940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BG574_10945 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG574_10950 ENOG4108JQ5 ABC transporter BG574_10955 ENOG4105C2N RNA methyltransferase TrmH family group 3 BG574_10960 ENOG4105JIM Phosphatidylserine synthase BG574_10970 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BG574_10975 ENOG4105DTN riboflavin biosynthesis protein ribF BG574_10980 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase BG574_10985 ENOG4108VVQ metallophosphoesterase BG574_10990 ENOG41065U4 response regulator BG574_11000 ENOG4108JQ1 Dehydrogenase BG574_11005 ENOG4105E66 phosphoriboisomerase A BG574_11010 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BG574_11015 ENOG4105C7B Threonine dehydratase BG574_11020 ENOG4108YZY peptidylprolyl cis-trans isomerase BG574_11025 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BG574_11035 ENOG4108R96 Methyltransferase, YaeB family BG574_11040 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BG574_11050 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG574_11055 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BG574_11070 ENOG4105PF3 O-Antigen polymerase BG574_11075 ENOG4105PF3 O-Antigen polymerase BG574_11080 ENOG4105C1B dTDP-glucose 4-6-dehydratase BG574_11085 ENOG4105D3Q Sugar transferase BG574_11090 ENOG4105D5D udp-galactopyranose mutase BG574_11110 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BG574_11115 ENOG4105VG0 50S ribosomal protein l34 BG574_11130 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BG574_11135 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) BG574_11145 ENOG4105WBN Transcriptional regulator (LacI family BG574_11155 ENOG4105D7K pfkb domain protein BG574_11160 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BG574_11165 ENOG4105C5Y PTS System BG574_11170 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BG574_11175 ENOG4105KZ7 phosphocarrier protein hpr BG574_11180 ENOG4106SMU thiamine transporter membrane protein BG574_11185 ENOG4107T0D ABC, transporter BG574_11190 ENOG4105C5Y PTS System BG574_11195 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BG574_11200 ENOG4105EX9 Membrane BG574_11205 ENOG4105C2I pirin domain protein BG574_11210 ENOG4105DSB aldose 1-epimerase BG574_11215 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 BG574_11225 ENOG4105M7P phage repressor BG574_11230 ENOG4105HVQ Regulatory factor of maltose metabolism BG574_11235 ENOG4108J1Q BG574_11240 ENOG4105C1J atp-dependent rna helicase BG574_11245 ENOG41090BQ Glutaredoxin BG574_11250 ENOG4105C8J )-transporter BG574_11255 ENOG4108JU6 CBS domain protein BG574_11260 ENOG4106KVJ cytochrome C assembly protein BG574_11265 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein BG574_11270 ENOG4105VGS 50s ribosomal protein l32 BG574_11275 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BG574_11280 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BG574_11290 ENOG4105C8V SAICAR synthetase BG574_11295 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BG574_11300 ENOG4105H2K paraquat-inducible protein a BG574_11305 ENOG41090HT Inherit from COG: transposase BG574_11310 ENOG4105EM2 membrane BG574_11315 ENOG4108Z5K methylglyoxal synthase BG574_11320 ENOG4105D98 threonine synthase BG574_11325 ENOG4105EHV domain protein BG574_11330 ENOG4105C5Q Transcriptional regulator BG574_11335 ENOG4105EJ2 Transcriptional regulator BG574_11350 ENOG4108J1Q BG574_11365 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BG574_11370 ENOG4105HF0 Membrane BG574_11380 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BG574_11395 ENOG4105C31 Tryptophanyl-tRNA synthetase BG574_11400 ENOG4105D0M Protease HtpX homolog BG574_11405 ENOG4105F0N pyrophosphate phospho-hydrolase BG574_11425 ENOG4105HHA aminodeoxychorismate lyase BG574_11430 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BG574_11435 ENOG4107QRG dna polymerase iii BG574_11450 ENOG4105F8V Hydrolase, tatD family BG574_11455 ENOG4105RX8 Protein of unknown function (DUF1523) BG574_11460 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) BG574_11465 ENOG4105K64 Glycosyl transferase, family 2 BG574_11505 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family BG574_11510 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) BG574_11520 ENOG4105C5F glutamine synthetase BG574_11525 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BG574_11535 ENOG4108IJ1 Dehydrogenase BG574_11545 ENOG4105ESV Glycosyl transferase, family 4 BG574_11570 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BG574_11590 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) BG574_11595 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) BG574_11600 ENOG4105WWK YheO domain protein BG574_11605 ENOG4108V1T peptidylprolyl cis-trans isomerase BG574_11610 ENOG4105VRX Protein slyX homolog BG574_11620 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) BG574_11625 ENOG4106YJS accessory processing protein BG574_11635 ENOG41076CZ activating enzyme BG574_11640 ENOG4105G0K glycine radical enzyme YjjI family BG574_11650 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BG574_11655 ENOG4108VZM 50s ribosomal protein L10 BG574_11665 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BG574_11675 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BG574_11680 ENOG4105C2D reductase BG574_11685 ENOG4105CB5 ATP-dependent DNA helicase recG BG574_11695 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BG574_11705 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BG574_11710 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BG574_11715 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BG574_11720 ENOG4105PM1 preprotein translocase subunit SecE BG574_11740 ENOG4105C79 DNA protecting protein DprA BG574_11755 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) BG574_11760 ENOG4105DAN ATP-dependent protease BG574_11765 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) BG574_11775 ENOG4105CQB FAD linked oxidase domain protein BG574_11780 ENOG4105KA0 thioesterase Superfamily protein BG574_11790 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BG574_11795 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase BG574_11805 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BG574_11830 ENOG4108J1Q BG574_11840 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase BG574_11845 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase BG574_11865 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BG574_11890 ENOG4105BZW Glycerate kinase BG574_11895 ENOG4105C6Z Gluconate BG574_11900 ENOG4107VHA regulatoR BG574_11915 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BG574_11920 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor BG574_11925 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BG574_11930 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BG574_11935 ENOG41083MP 50s ribosomal protein l29 BG574_11940 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BG574_11945 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BG574_11950 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BG574_11955 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BG574_11960 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BG574_11965 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BG574_11970 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BG574_11975 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BG574_11990 ENOG4105C9Q fumarate hydratase class II BG574_11995 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BG574_12000 ENOG4108K3A Glutathione S-transferase BG574_12005 ENOG4105D1U peptidase U62 modulator of DNA gyrase BG574_12010 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BG574_12055 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) BG574_12060 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) BG574_12065 ENOG4105E33 succinate dehydrogenase BG574_12070 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) BG574_12075 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) BG574_12080 ENOG4105FR1 rard protein BG574_12085 ENOG4105EU0 Major facilitator Superfamily BG574_12090 ENOG4105EU0 Major facilitator Superfamily BG574_12095 ENOG4105C94 Transporter BG574_12105 ENOG4105CJR Integral membrane protein (MviN BG574_12110 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BG574_12115 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BG574_12120 ENOG4108RR8 protoporphyrinogen oxidase BG574_12125 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) BG574_12130 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BG574_12140 ENOG4105DKW ABC transporter BG574_12150 ENOG4105EHG Permease protein BG574_12155 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BG574_12165 ENOG4105S10 periplasmic binding protein BG574_12170 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BG574_12175 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) BG574_12185 ENOG4105DZ1 carboxypeptidase BG574_12195 ENOG4105CNI cell division protein FtsW BG574_12200 ENOG4105CJN penicillin-binding protein BG574_12205 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BG574_12210 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) BG574_12220 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BG574_12225 ENOG4107YCY Transcriptional regulator BG574_12230 ENOG4105DMW Dehydrogenase reductase BG574_12245 ENOG4105CT4 transporter BG574_12260 ENOG4108UHU Aldolase BG574_12265 ENOG4108R0G Tetratricopeptide repeat protein BG574_12285 ENOG4108V1T peptidylprolyl cis-trans isomerase BG574_12290 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BG574_12305 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BG574_12310 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BG574_12360 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BG574_12370 ENOG4108XTF Outer Membrane Lipoprotein BG574_12375 ENOG4106ZCM YecM protein BG574_12380 ENOG4105C75 arginyL-tRNA synthetase BG574_12385 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BG574_12390 ENOG4105WV0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) BG574_12395 ENOG4105DA4 cytochrome c-type biogenesis protein BG574_12405 ENOG4105X3C heme exporter protein BG574_12410 ENOG41060IM Heme exporter protein BG574_12415 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) BG574_12420 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) BG574_12425 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) BG574_12430 ENOG4105DEF Extracellular solute-binding protein, family 5 BG574_12435 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BG574_12440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG574_12445 ENOG4105C3U ABC transporter BG574_12450 ENOG4108JQ7 (ABC) transporter BG574_12465 ENOG4105E0X reductase BG574_12470 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BG574_12475 ENOG4108J1Q BG574_12480 ENOG4105ERU peptidase BG574_12495 ENOG4108J1Q BG574_12520 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BG574_12530 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) BG574_12540 ENOG4108I5U Uridine phosphorylase BG574_12555 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BG574_12565 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BG574_12580 ENOG4105CB5 ATP-dependent DNA helicase recG BG574_12585 ENOG4105DU0 nucleoside hydrolase BG574_12590 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain BG574_12595 ENOG4107QJE Chromosome Partitioning Protein BG574_12605 ENOG4105E12 capsule polysaccharide BG574_12655 ENOG4105K5B UPF0225 protein