locus-tag class description Mame_00001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Mame_00002 ENOG4105KUZ arsenate reductase Mame_00003 ENOG4108Z66 YbaK ebsC protein Mame_00006 ENOG4105C88 aminopeptidase Mame_00007 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Mame_00012 ENOG4105CPC Aldo Keto reductase Mame_00014 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Mame_00015 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Mame_00016 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) Mame_00021 ENOG4105DEF Extracellular solute-binding protein, family 5 Mame_00022 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Mame_00024 ENOG4108JQ7 (ABC) transporter Mame_00026 ENOG4107SCA Formamidase (EC 3.5.1.49) Mame_00027 ENOG4105DER m42 family Mame_00028 ENOG4105CPF Cell wall formation (By similarity) Mame_00029 ENOG4105CAQ asparagine synthetase Mame_00035 ENOG4108IGT Dipeptidase Mame_00036 ENOG4105E1J oxidoreductase Mame_00037 ENOG4105RQF LysR family Transcriptional regulator Mame_00038 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Mame_00040 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_00046 ENOG4108PZW LysR family Transcriptional regulator Mame_00048 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) Mame_00051 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Mame_00054 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Mame_00055 ENOG4105DIH basic membrane Mame_00056 ENOG4108JQ9 ABC transporter Mame_00060 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) Mame_00061 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) Mame_00062 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) Mame_00064 ENOG4105P0T Usg family Mame_00065 ENOG4105CV8 reductase Mame_00071 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) Mame_00072 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Mame_00073 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Mame_00074 ENOG4105P5X ATP phosphoribosyltransferase regulatory subunit Mame_00076 ENOG4105C8Y Acetylornithine aminotransferase Mame_00077 ENOG4105ENR peptidase, M24 Mame_00080 ENOG4105CKI cobalamin synthesis protein Mame_00081 ENOG4107S8C mandelate racemase muconate lactonizing Mame_00087 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Mame_00088 ENOG4107QUT magnesium and cobalt transport protein CorA Mame_00089 ENOG4107PQ6 Inherit from NOG: atp synthase Mame_00090 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) Mame_00091 ENOG4105VD1 ATP synthase subunit C Mame_00092 ENOG4108VHN F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Mame_00093 ENOG4105N5Q Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Mame_00094 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Mame_00096 ENOG4105C26 Dehydrogenase Mame_00098 ENOG4105P4J Allophanate hydrolase, subunit 1 Mame_00099 ENOG4107QKW extracellular solute-binding protein family 1 Mame_00100 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_00101 ENOG4107RCV ABC transporter, permease Mame_00103 ENOG4105E98 transcriptional regulator DeoR family Mame_00105 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Mame_00108 ENOG4105C94 Transporter Mame_00109 ENOG4108KEZ Dehydrogenase Mame_00110 ENOG4105C5R Aminotransferase Mame_00111 ENOG4107U32 Beta-lactamase domain protein Mame_00113 ENOG4105UIB (ABC) transporter Mame_00114 ENOG4108JQ9 ABC transporter Mame_00120 ENOG4107XBN GntR Family Transcriptional Regulator Mame_00121 ENOG4108XEP Alpha Beta Hydrolase Fold protein Mame_00125 ENOG4108S8N class II Aldolase Mame_00126 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) Mame_00129 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) Mame_00131 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_00132 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Mame_00134 ENOG4105D7T ABC transporter Mame_00135 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Mame_00137 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) Mame_00138 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) Mame_00139 ENOG4108IV0 ABC, transporter Mame_00140 ENOG4105C0Z ABC transporter Mame_00141 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Mame_00143 ENOG4105CAD extracellular ligand-binding receptor Mame_00146 ENOG4108K2P TRANSCRIPTIONal Mame_00149 ENOG4105DIK (ABC) transporter Mame_00151 ENOG4108MEK Metal-binding protein YodA Mame_00152 ENOG4105CKI cobalamin synthesis protein Mame_00157 ENOG4105CDA abc transporter atp-binding protein Mame_00158 ENOG4105DRP amino acid AbC transporter Mame_00159 ENOG4105EZ7 amino acid ABC transporter Mame_00160 ENOG4107QXX ABC transporter Mame_00161 ENOG4105C28 cystathionine Mame_00163 ENOG4105CC0 LysR family Transcriptional regulator Mame_00165 ENOG4105ETE Transcriptional regulator (LacI family Mame_00166 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component Mame_00167 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_00168 ENOG4107RUE extracellular solute-binding protein family 1 Mame_00169 ENOG4105D81 ABC transporter, permease Mame_00170 ENOG4107QK4 glycoside hydrolase, family 3 domain protein Mame_00171 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Mame_00180 ENOG4105E39 Enoyl-CoA hydratase Mame_00182 ENOG4105CEY Amp-dependent synthetase and ligase Mame_00183 ENOG4105E39 Enoyl-CoA hydratase Mame_00186 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Mame_00190 ENOG4105C4Y ABC transporter Mame_00192 ENOG4105JSC dimethylmenaquinone methyltransferase Mame_00195 ENOG4105C5I Dehydrogenase Mame_00196 ENOG4105WH1 Two component transcriptional regulator luxr family Mame_00198 ENOG4106FGB Beta-lactamase Mame_00199 ENOG4105H3G oxidoreductase Mame_00200 ENOG4105KME endoribonuclease L-psp Mame_00203 ENOG4105CWC Acetylornithine deacetylase Mame_00204 ENOG4105DVW rieske (2Fe-2S) Mame_00205 ENOG4105R40 Glycine betaine carnitine choline Mame_00209 ENOG4106KR7 LysR family Transcriptional regulator Mame_00211 ENOG4105CBG Sulfatase Mame_00212 ENOG4105CBG Sulfatase Mame_00213 ENOG4105D17 glycoside hydrolase, family 3 domain protein Mame_00216 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_00218 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Mame_00220 ENOG4107QK4 glycoside hydrolase, family 3 domain protein Mame_00227 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase Mame_00228 ENOG4106IEQ Mame_00230 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Mame_00231 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Mame_00232 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Mame_00233 ENOG4108061 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Mame_00238 ENOG41082MC Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Mame_00239 ENOG4105UHE Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Mame_00241 ENOG4105C5B carbamate kinase Mame_00242 ENOG4105DBV ornithine carbamoyltransferase Mame_00243 ENOG4105CEU Arginine dihydrolase Mame_00244 ENOG4105CSX c4-dicarboxylate anaerobic carrier Mame_00245 ENOG4108Z0Z intracellular protease Pfpi family Mame_00248 ENOG4105C1B dTDP-glucose 4-6-dehydratase Mame_00250 ENOG4105X1N Glycosyl transferase family 8 Mame_00252 ENOG4108JQC penicillin-binding protein 1A Mame_00253 ENOG410600T transposase Mame_00254 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Mame_00256 ENOG4105C2M dna polymerase I Mame_00257 ENOG4105CNN ABC, transporter Mame_00258 ENOG4105C2J ABC transporter Mame_00261 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Mame_00264 ENOG4106IPI cyclase, family Mame_00267 ENOG4105C93 Xylose Isomerase Mame_00268 ENOG4105CMG Carbohydrate kinase Mame_00269 ENOG4105ETE Transcriptional regulator (LacI family Mame_00273 ENOG4105E98 transcriptional regulator DeoR family Mame_00275 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Mame_00281 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein Mame_00283 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_00286 ENOG4105CNV Aldolase Mame_00287 ENOG41082BM Transcriptional regulator, arsr family Mame_00290 ENOG4105C9B Cysteine desulfurase Mame_00292 ENOG4105E5Q amino acid AbC transporter Mame_00297 ENOG4105EG2 ABC transporter, permease Mame_00298 ENOG4108IJ9 (ABC) transporter Mame_00299 ENOG4107VXM glycerophosphoryl diester phosphodiesterase Mame_00300 ENOG4105ETE Transcriptional regulator (LacI family Mame_00301 ENOG4105ECY inositol monophosphatase Mame_00304 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component Mame_00306 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) Mame_00309 ENOG4105CPC Aldo Keto reductase Mame_00315 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_00318 ENOG4105CNN ABC, transporter Mame_00319 ENOG4105C2J ABC transporter Mame_00323 ENOG4107YCY Transcriptional regulator Mame_00326 ENOG4105DEF Extracellular solute-binding protein, family 5 Mame_00328 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Mame_00329 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_00330 ENOG4105C3U ABC transporter Mame_00333 ENOG4105ETE Transcriptional regulator (LacI family Mame_00335 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Mame_00343 ENOG4105DG4 malate L-lactate dehydrogenase Mame_00345 ENOG4105MWK D-amino acid dehydrogenase, small subunit Mame_00346 ENOG4105DRR Transcriptional regulator, GntR family Mame_00358 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Mame_00359 ENOG4105C32 Amino acid ABC transporter (Permease) Mame_00360 ENOG4108IV0 ABC, transporter Mame_00361 ENOG4108IUZ ABC transporter Mame_00364 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) Mame_00366 ENOG4105CNN ABC, transporter Mame_00368 ENOG4108IV0 ABC, transporter Mame_00369 ENOG4108IUZ ABC transporter Mame_00371 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Mame_00373 ENOG4108J59 Extracellular solute-binding protein, family 5 Mame_00374 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Mame_00375 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_00382 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Mame_00385 ENOG4105F2Z 3-oxoadipate enol-lactonase Mame_00391 ENOG4106KR7 LysR family Transcriptional regulator Mame_00395 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Mame_00398 ENOG4106KR7 LysR family Transcriptional regulator Mame_00400 ENOG4105CNN ABC, transporter Mame_00401 ENOG4105C2J ABC transporter Mame_00402 ENOG4108SV3 Tmao reductase system periplasmic protein tort Mame_00404 ENOG4105ECP epimerase Mame_00405 ENOG4105C2J ABC transporter Mame_00407 ENOG4105ETE Transcriptional regulator (LacI family Mame_00408 ENOG4107R11 Transcriptional regulator Mame_00410 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_00411 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Mame_00412 ENOG4105S0E allantoin catabolism protein Mame_00418 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Mame_00419 ENOG4108KC2 acyl-Coa dehydrogenase Mame_00420 ENOG4105CC9 acyl-Coa dehydrogenase Mame_00423 ENOG4105F2Z 3-oxoadipate enol-lactonase Mame_00424 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Mame_00426 ENOG4105EW6 flavin reductase domain protein, FMN-binding Mame_00427 ENOG41060WC Enoyl-CoA hydratase Mame_00430 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Mame_00431 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Mame_00433 ENOG4105S10 periplasmic binding protein Mame_00434 ENOG4105EHG Permease protein Mame_00435 ENOG4108W0P ABC transporter Mame_00437 ENOG4105E7U AraC family transcriptional regulator Mame_00441 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_00442 ENOG4108JQ5 ABC transporter Mame_00443 ENOG4105F8D glycoside hydrolase family 4 Mame_00445 ENOG4105EBR Carboxylesterase Mame_00447 ENOG4105C3U ABC transporter Mame_00456 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Mame_00457 ENOG4108IUS Transketolase Mame_00458 ENOG4108HHA Transketolase Mame_00459 ENOG4105CNN ABC, transporter Mame_00460 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Mame_00461 ENOG4105C2J ABC transporter Mame_00462 ENOG4108KEZ Dehydrogenase Mame_00463 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr Mame_00465 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Mame_00466 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_00467 ENOG4108JQ6 ABC transporter Mame_00471 ENOG4105DEF Extracellular solute-binding protein, family 5 Mame_00472 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Mame_00475 ENOG4105CNN ABC, transporter Mame_00476 ENOG4105C2J ABC transporter Mame_00477 ENOG4105FDP GntR family transcriptional regulator Mame_00478 ENOG4105EXW epimerase dehydratase Mame_00479 ENOG4105G63 Type III effector Hrp-dependent Mame_00480 ENOG4105FB2 class II Aldolase Mame_00481 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) Mame_00484 ENOG4105BZU Histidine kinase Mame_00488 ENOG4105C0Z ABC transporter Mame_00489 ENOG4108IV0 ABC, transporter Mame_00495 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Mame_00497 ENOG4107QX3 carboxylase Mame_00498 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_00506 ENOG4105CHU acetyl-coa acetyltransferase Mame_00507 ENOG4105C1G acyl-Coa dehydrogenase Mame_00510 ENOG4108UKI Enoyl-CoA hydratase Mame_00515 ENOG4105TPV Mame_00516 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Mame_00517 ENOG4105D2B acyl-CoA dehydrogenase Mame_00518 ENOG4105CC9 acyl-Coa dehydrogenase Mame_00519 ENOG4105CHR reductase Mame_00520 ENOG4105CC9 acyl-Coa dehydrogenase Mame_00521 ENOG4105C1G acyl-Coa dehydrogenase Mame_00522 ENOG4105E39 Enoyl-CoA hydratase Mame_00523 ENOG4105CEY Amp-dependent synthetase and ligase Mame_00524 ENOG4108FUF Transcriptional regulator, IclR family Mame_00525 ENOG410900P UPF0336 protein Mame_00527 ENOG4106YT9 Enoyl-CoA hydratase Mame_00530 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_00531 ENOG4105CI0 Citrate lyase Mame_00532 ENOG4108M9J MaoC like domain protein Mame_00533 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F Mame_00537 ENOG4108WYP Transcriptional regulator Mame_00539 ENOG4108IV0 ABC, transporter Mame_00540 ENOG4105C0Z ABC transporter Mame_00542 ENOG4105C32 Amino acid ABC transporter (Permease) Mame_00544 ENOG4105CHR reductase Mame_00546 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Mame_00547 ENOG4105BZS acriflavin resistance protein Mame_00548 ENOG4105C1P efflux transporter, rnd family, mfp subunit Mame_00550 ENOG4105DEF Extracellular solute-binding protein, family 5 Mame_00553 ENOG4108JQ6 ABC transporter Mame_00554 ENOG4105CXK mandelate racemase muconate lactonizing Mame_00555 ENOG4105E9Z Nad-dependent epimerase dehydratase Mame_00556 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) Mame_00557 ENOG4105JXH GntR family transcriptional regulator Mame_00558 ENOG4105JSC dimethylmenaquinone methyltransferase Mame_00559 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Mame_00562 ENOG4105C6K Malic enzyme Mame_00563 ENOG4105C5I Dehydrogenase Mame_00565 ENOG4105E9Z Nad-dependent epimerase dehydratase Mame_00567 ENOG4107QRA Extracellular solute-binding protein, family 5 Mame_00568 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Mame_00569 ENOG4108XM1 transcriptional regulator AsnC family Mame_00570 ENOG4105C3J Cysteine desulfurase Mame_00571 ENOG4105E1J oxidoreductase Mame_00574 ENOG4105C5I Dehydrogenase Mame_00576 ENOG4105CMM transposase Mame_00586 ENOG4105BZS acriflavin resistance protein Mame_00587 ENOG4105C1P efflux transporter, rnd family, mfp subunit Mame_00589 ENOG4105C8V SAICAR synthetase Mame_00590 ENOG410829K Lysine exporter protein (Lyse ygga) Mame_00591 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Mame_00594 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation Mame_00597 ENOG4105I8F Histidine kinase Mame_00602 ENOG4106N3A copper homeostasis protein cutc Mame_00605 ENOG4105E2D ec 3.2.1.52 Mame_00606 ENOG4105CHC glucokinase (EC 2.7.1.2) Mame_00609 ENOG4105CFG Acts as a chaperone (By similarity) Mame_00610 ENOG41069B0 Membrane-bound lysozyme-inhibitor of c-type lysozyme Mame_00613 ENOG4105EUJ GTP cyclohydrolase i Mame_00625 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Mame_00626 ENOG4106F59 XRE family Transcriptional regulator Mame_00628 ENOG4108K2P TRANSCRIPTIONal Mame_00631 ENOG4105CPQ Dehydrogenase Mame_00633 ENOG4105CEY Amp-dependent synthetase and ligase Mame_00634 ENOG4108R85 Short chain dehydrogenase Mame_00635 ENOG4108JQ7 (ABC) transporter Mame_00636 ENOG4105C3U ABC transporter Mame_00637 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_00638 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Mame_00639 ENOG4105DEF Extracellular solute-binding protein, family 5 Mame_00641 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Mame_00642 ENOG4108IYU L-aspartate oxidase Mame_00643 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Mame_00651 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) Mame_00652 ENOG4105WAZ (Glutaredoxin-like protein) NrdH Mame_00654 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) Mame_00655 ENOG4105CCU oxidase (Subunit III) Mame_00656 ENOG4105BZ9 Cytochrome C oxidase, subunit I Mame_00657 ENOG4105E2S oxidase) subunit II Mame_00659 ENOG4107QP8 phosphohexose isomerase Mame_00660 ENOG4108IV0 ABC, transporter Mame_00661 ENOG4105C0Z ABC transporter Mame_00663 ENOG4105C32 Amino acid ABC transporter (Permease) Mame_00669 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Mame_00671 ENOG4105KME endoribonuclease L-psp Mame_00677 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Mame_00681 ENOG4105C2J ABC transporter Mame_00682 ENOG4105CNN ABC, transporter Mame_00683 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Mame_00684 ENOG410804X Transcriptional regulator Mame_00689 ENOG4107SVN transposase Mame_00690 ENOG4108YZG isomerase Mame_00691 ENOG4105CP7 Triose-phosphate isomerase Mame_00694 ENOG4107P2S Transcriptional regulator Mame_00695 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Mame_00696 ENOG4106UW1 Major Facilitator superfamily Mame_00698 ENOG4108ZT1 Transcriptional regulator Mame_00699 ENOG4108KTG Membrane protein, drug metabolite transporter Mame_00700 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) Mame_00701 ENOG4105CSH Transporter Mame_00702 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Mame_00703 ENOG4108UYB regulatoR Mame_00707 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Mame_00708 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Mame_00711 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Mame_00712 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) Mame_00715 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein Mame_00716 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Mame_00718 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Mame_00719 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Mame_00720 ENOG4105DEI Mannitol dehydrogenase Mame_00721 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_00725 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Mame_00726 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system Mame_00727 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component Mame_00728 ENOG4108IJ8 ABC transporter Mame_00729 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component Mame_00731 ENOG4108YYH Nadph-dependent fmn reductase Mame_00732 ENOG4105KVH Transcriptional regulator Mame_00733 ENOG410600T transposase Mame_00734 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Mame_00737 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Mame_00739 ENOG4105DFA alanine racemase domain protein Mame_00740 ENOG4105C8T Leucyl-tRNA synthetase Mame_00743 ENOG4105FA0 parb-like partition protein Mame_00744 ENOG4107QJE Chromosome Partitioning Protein Mame_00745 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) Mame_00746 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Mame_00747 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Mame_00748 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Mame_00749 ENOG4108YXA Membrane Mame_00750 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Mame_00751 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) Mame_00752 ENOG4108UHJ MAF-like protein Mame_00753 ENOG4105E2X shikimate dehydrogenase Mame_00755 ENOG4108JDX DNA polymerase iii, epsilon subunit Mame_00757 ENOG4105DKT Transcriptional regulator Mame_00758 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) Mame_00761 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Mame_00762 ENOG4105TX3 Histidine kinase Mame_00763 ENOG4105CQ7 ATP-dependent helicase Mame_00765 ENOG4105BZU Histidine kinase Mame_00766 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Mame_00767 ENOG4105CMD Transcriptional regulator, GntR family Mame_00768 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) Mame_00769 ENOG4107QM2 Aldo Keto reductase Mame_00772 ENOG4108R6K riboflavin synthase, subunit alpha Mame_00774 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Mame_00775 ENOG4105CDH Citrulline--aspartate ligase Mame_00779 ENOG4105DGW oligopeptidase A Mame_00781 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Mame_00782 ENOG4105BZU Histidine kinase Mame_00784 ENOG4105C8U phosphate abc transporter Mame_00786 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Mame_00787 ENOG4108UTW Plays a role in the regulation of phosphate uptake Mame_00788 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Mame_00789 ENOG4105F95 Monooxygenase Mame_00794 ENOG4105F0I Aminotransferase Mame_00797 ENOG4105CF1 Alkylated DNA repair protein Mame_00798 ENOG4108YZN class I peptide chain release factor Mame_00800 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase Mame_00801 ENOG4105E3W Two component transcriptional regulator (Winged helix family Mame_00802 ENOG4105EB3 Histidine kinase Mame_00804 ENOG4108EQA pts system Mame_00805 ENOG41080Z8 PHOSPHOCARRIER protein Mame_00812 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Mame_00813 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Mame_00818 ENOG4105BZU Histidine kinase Mame_00822 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 Mame_00823 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) Mame_00826 ENOG4108WYP Transcriptional regulator Mame_00827 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Mame_00828 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Mame_00831 ENOG4105CXK mandelate racemase muconate lactonizing Mame_00835 ENOG4105CBG Sulfatase Mame_00836 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) Mame_00839 ENOG4108IJ7 Glycine betaine Mame_00843 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Mame_00846 ENOG4107TYG Oxidoreductase domain-containing protein Mame_00847 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) Mame_00848 ENOG4105E39 Enoyl-CoA hydratase Mame_00849 ENOG4105C26 Dehydrogenase Mame_00850 ENOG4108JP0 extracellular solute-binding protein family 1 Mame_00851 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Mame_00855 ENOG4105CHR reductase Mame_00858 ENOG4105ZWB Outer membrane lipoprotein Mame_00859 ENOG4105CGH 5'-nucleotidase Mame_00860 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Mame_00861 ENOG4107QX8 SPFH domain, Band 7 family protein Mame_00862 ENOG4105G5H Membrane Mame_00870 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Mame_00871 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Mame_00873 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Mame_00874 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Mame_00875 ENOG41082BR 50S ribosomal protein L35 Mame_00876 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Mame_00877 ENOG4107XM9 (LipO)protein Mame_00879 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Mame_00882 ENOG4106TD9 Diguanylate cyclase Mame_00883 ENOG4105CTB Polyprenyl synthetase Mame_00884 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase Mame_00885 ENOG4108TGY Glutathione S-transferase Mame_00887 ENOG4108NVM synthesis repressor PhaR Mame_00888 ENOG4105CHU acetyl-coa acetyltransferase Mame_00895 ENOG4108Z4U Ferredoxin Mame_00896 ENOG4108VJ1 Transcriptional regulator (CarD family Mame_00897 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Mame_00899 ENOG4107T0D ABC, transporter Mame_00904 ENOG4108YZY peptidylprolyl cis-trans isomerase Mame_00905 ENOG4105DJ9 glucan biosynthesis protein Mame_00907 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) Mame_00912 ENOG4105C5H ABC transporter Mame_00914 ENOG4105IPI Membrane Mame_00916 ENOG4105CNN ABC, transporter Mame_00917 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Mame_00921 ENOG4108IJ9 (ABC) transporter Mame_00923 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Mame_00924 ENOG4105D56 permease protein Mame_00930 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Mame_00931 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Mame_00934 ENOG4105E2A Dehydrogenase Mame_00937 ENOG4108ZMQ domain protein Mame_00942 ENOG4105CS9 pantothenic acid kinase Mame_00943 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase Mame_00944 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Mame_00945 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Mame_00946 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Mame_00947 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Mame_00950 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Mame_00952 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Mame_00953 ENOG4105CPC Aldo Keto reductase Mame_00954 ENOG4107QP3 malate synthase g Mame_00955 ENOG4105DRR Transcriptional regulator, GntR family Mame_00956 ENOG4108NNI Beta-lactamase domain-containing protein Mame_00957 ENOG4105H9W Short-chain dehydrogenase reductase Sdr Mame_00959 ENOG4105CPN adenine deaminase Mame_00963 ENOG4105F38 ABC transporter, permease Mame_00964 ENOG4105E0C molybdate abc transporter Mame_00965 ENOG4108IJ9 (ABC) transporter Mame_00967 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) Mame_00968 ENOG4105E0C molybdate abc transporter Mame_00969 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Mame_00973 ENOG4105C94 Transporter Mame_00974 ENOG4105D1F ATP-binding protein Mame_00975 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein Mame_00976 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Mame_00980 ENOG4107QZ7 Cellulose synthase catalytic subunit Mame_00982 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) Mame_00988 ENOG4108ZNX Heat shock protein Mame_00996 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A Mame_00997 ENOG4105K8R UPF0145 protein Mame_01000 ENOG4105C2X Arabinose 5-phosphate isomerase Mame_01002 ENOG4108UM1 dedA family Mame_01005 ENOG4105VDW Csbd family Mame_01007 ENOG41074H6 response regulator Mame_01011 ENOG4105C29 acyl-CoA thioesterase Mame_01012 ENOG4108YZA Nitrogen regulatory protein pii Mame_01016 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) Mame_01017 ENOG4107U9T Pfam:Ribonuclease_BN Mame_01018 ENOG4105E1F short-chain dehydrogenase reductase Mame_01019 ENOG4108UVJ appr-1-p processing domain protein Mame_01022 ENOG4105BZJ Electron transfer flavoprotein Mame_01023 ENOG4105C10 Electron transfer flavoprotein Mame_01026 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Mame_01029 ENOG4105I1K ABC transporter Mame_01032 ENOG4105CPC Aldo Keto reductase Mame_01033 ENOG4107S5I aldo keto reductase Mame_01035 ENOG4105EWV Sodium calcium exchanger membrane region Mame_01037 ENOG4105CFU surface antigen Mame_01039 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Mame_01040 ENOG4107S1E Beta-lactamase Mame_01041 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Mame_01042 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Mame_01046 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Mame_01047 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Mame_01048 ENOG4107PU6 Membrane Mame_01049 ENOG4105C6T cysteine synthase Mame_01050 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit Mame_01052 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_01053 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Mame_01054 ENOG4105BZU Histidine kinase Mame_01058 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Mame_01060 ENOG4105DVW rieske (2Fe-2S) Mame_01062 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) Mame_01063 ENOG4105FD8 phosphonate metabolism protein PhnM Mame_01064 ENOG4108TXN phosphonate metabolism protein Mame_01066 ENOG4105HFZ Membrane Mame_01068 ENOG4105CV6 ABC transporter, permease Mame_01069 ENOG4108I0Y (ABC) transporter Mame_01071 ENOG4105M7V 2'-5' rna ligase Mame_01072 ENOG4105KJF protein tyrosine phosphatase Mame_01073 ENOG4105KZX Pterin carbinolamine dehydratase Mame_01076 ENOG4105CHR reductase Mame_01080 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) Mame_01082 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) Mame_01083 ENOG4105EF1 ribulokinase Mame_01084 ENOG41062B0 ABC transporter, permease Mame_01085 ENOG4107R9N ABC transporter Mame_01086 ENOG4105C2J ABC transporter Mame_01087 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator Mame_01089 ENOG4108RW8 Universal stress protein F Mame_01097 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Mame_01098 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Mame_01100 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Mame_01107 ENOG4105C1J atp-dependent rna helicase Mame_01108 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Mame_01116 ENOG4108Z2U ureidoglycolate hydrolase Mame_01117 ENOG4105VT2 5-hydroxyisourate hydrolase Mame_01119 ENOG4105DMF Dehydrogenase Mame_01120 ENOG4107QUY Guanine deaminase Mame_01123 ENOG4105C7W Xanthine dehydrogenase Mame_01131 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Mame_01136 ENOG4105BZF Glycosyl transferase (Group 1 Mame_01137 ENOG4105CG3 alpha amylase, catalytic region Mame_01138 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Mame_01140 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Mame_01141 ENOG41080HT Transcriptional regulator, arsr family Mame_01143 ENOG4108IJ7 Glycine betaine Mame_01144 ENOG4107104 thymidine kinase Mame_01145 ENOG4105VJY transcriptional regulator Mame_01146 ENOG4105C6K Malic enzyme Mame_01147 ENOG4105MGM doxx family Mame_01150 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) Mame_01156 ENOG4105CAR Terminase, large subunit Mame_01187 ENOG4105PGM cation diffusion facilitator family transporter Mame_01189 ENOG4105E1F short-chain dehydrogenase reductase Mame_01191 ENOG4105CH6 catalase Mame_01192 ENOG4105C5Q Transcriptional regulator Mame_01195 ENOG4108R3E Dna-3-methyladenine glycosylase i Mame_01196 ENOG4105HMI Membrane Mame_01197 ENOG41090KR LysR family transcriptional Regulator Mame_01199 ENOG4105CUT histidyl-tRNA synthetase Mame_01201 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Mame_01202 ENOG4105C4M (Ubiquinol oxidase) subunit I Mame_01203 ENOG4108JJ8 (ABC) transporter Mame_01204 ENOG4108JJ9 ABC, transporter Mame_01210 ENOG4105CHR reductase Mame_01211 ENOG4105CBN LysR family transcriptional regulator Mame_01212 ENOG4105DQS Transcriptional regulator Mame_01213 ENOG4105FDP GntR family transcriptional regulator Mame_01215 ENOG4105CE4 GlcNAc 6-P deacetylase Mame_01217 ENOG4105CMS peptidase U62, modulator of DNA gyrase Mame_01218 ENOG4107TK4 histidinol-phosphate phosphatase Mame_01220 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase Mame_01221 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) Mame_01223 ENOG4105F0N pyrophosphate phospho-hydrolase Mame_01224 ENOG4105FE5 Homospermidine synthase Mame_01229 ENOG4105EAQ (twin-arginine translocation) pathway signal Mame_01230 ENOG4105MHT Transcriptional regulator, ARSR family Mame_01231 ENOG4105FKQ transcriptional regulator Mame_01232 ENOG4105EPJ extracellular solute-binding protein family 1 Mame_01233 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component Mame_01234 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component Mame_01235 ENOG4105CG3 alpha amylase, catalytic region Mame_01236 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_01238 ENOG4105C01 Dihydroxy-acid dehydratase Mame_01239 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) Mame_01240 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Mame_01241 ENOG4105CJP fad dependent oxidoreductase Mame_01242 ENOG4105CFQ glutamine synthetase Mame_01243 ENOG4105CBX hi0933 family Mame_01249 ENOG4105K5G 30S ribosomal protein S21 Mame_01251 ENOG4108M8W Monooxygenase Mame_01255 ENOG4105C84 Histidine ammonia-lyase Mame_01257 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Mame_01259 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Mame_01261 ENOG4105FDP GntR family transcriptional regulator Mame_01262 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Mame_01263 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Mame_01264 ENOG4105CHC glucokinase (EC 2.7.1.2) Mame_01265 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) Mame_01267 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component Mame_01268 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component Mame_01269 ENOG4108JQ5 ABC transporter Mame_01271 ENOG4105C32 Amino acid ABC transporter (Permease) Mame_01273 ENOG4105C0Z ABC transporter Mame_01274 ENOG4108IV0 ABC, transporter Mame_01275 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Mame_01276 ENOG4108YZ9 Urea amidohydrolase subunit gamma Mame_01277 ENOG4105KI2 Urea amidohydrolase subunit beta Mame_01279 ENOG4105CQM Urea amidohydrolase subunit alpha Mame_01281 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) Mame_01282 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Mame_01283 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) Mame_01288 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Mame_01289 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Mame_01292 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Mame_01294 ENOG4105CD3 dihydroorotase Mame_01296 ENOG4105WDY DNA (cytosine-5-)-methyltransferase Mame_01297 ENOG4105CE7 Amidase, hydantoinase carbamoylase family Mame_01298 ENOG4108R86 Transcriptional regulator Mame_01299 ENOG4105BZU Histidine kinase Mame_01300 ENOG4107SJI Dehydrogenase Mame_01301 ENOG4105BZ8 glutamate synthase Mame_01305 ENOG4107RH7 Nicotinate phosphoribosyltransferase Mame_01308 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Mame_01310 ENOG4105EHG Permease protein Mame_01311 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Mame_01312 ENOG4105CFH Aspartokinase Mame_01313 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase Mame_01314 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Mame_01315 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Mame_01317 ENOG4105CAT Cytidine monophosphate kinase Mame_01318 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Mame_01321 ENOG4108IEG Formate dehydrogenase Alpha subunit Mame_01322 ENOG4107QIZ NADH dehydrogenase Mame_01330 ENOG4105CMM transposase Mame_01337 ENOG4105F5W AtP-binding protein Mame_01350 ENOG4106VZX establishment of viral latency Mame_01356 ENOG41069P5 Protein slyX homolog Mame_01357 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Mame_01369 ENOG4105WEM extracellular solute-binding protein Mame_01370 ENOG4105ETE Transcriptional regulator (LacI family Mame_01371 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Mame_01372 ENOG4105DZG Dehydrogenase Mame_01373 ENOG4105EXU Membrane Mame_01381 ENOG4105C3U ABC transporter Mame_01382 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_01384 ENOG4105DEF Extracellular solute-binding protein, family 5 Mame_01389 ENOG4105D7X high-affinity nickel-transporter Mame_01390 ENOG4108IJ6 ABC transporter Mame_01391 ENOG4105ECW sulfate abc transporter Mame_01392 ENOG4108I5D sulfate abc transporter Mame_01393 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein Mame_01394 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Mame_01399 ENOG4105CYM Glutathione S-transferase Mame_01400 ENOG4107QX3 carboxylase Mame_01401 ENOG4105CFF transcriptional regulator Mame_01402 ENOG4105CC0 LysR family Transcriptional regulator Mame_01405 ENOG4108YYD acetyltransferase Mame_01411 ENOG41090A1 ferritin Mame_01413 ENOG4107XBN GntR Family Transcriptional Regulator Mame_01414 ENOG4107SS6 2-dehydro-3-deoxygluconokinase Mame_01417 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Mame_01420 ENOG4105C7J ABC transporter, permease Mame_01423 ENOG4108X0B nad(p)h dehydrogenase (quinone) Mame_01425 ENOG4107TTD cytosine deaminase Mame_01426 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component Mame_01428 ENOG4107XKF NMT1 THI5 Like Domain Protein Mame_01432 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Mame_01435 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Mame_01443 ENOG4105EFQ Two component transcriptional regulator (Winged helix family Mame_01448 ENOG4105K63 Thioredoxin Mame_01450 ENOG4105W49 UPF0434 protein Mame_01456 ENOG4105C0P Mg chelatase subunit ChlI Mame_01458 ENOG4105D7Z glutathione synthase Mame_01459 ENOG4108IJ9 (ABC) transporter Mame_01463 ENOG41082FP UPF0102 protein Mame_01464 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Mame_01465 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Mame_01466 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) Mame_01471 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Mame_01473 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) Mame_01474 ENOG4105D6J arsenicaL-resistance protein Mame_01478 ENOG4106JUT Streptomycin 3''-adenylyltransferase Mame_01479 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Mame_01481 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Mame_01482 ENOG4107QMP dna polymerase iii subunits gamma and tau Mame_01483 ENOG4108UIN ybak prolyl-trna synthetase associated region Mame_01486 ENOG4105E09 nadh pyrophosphatase Mame_01490 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) Mame_01491 ENOG4105G9V cytochrome C Mame_01494 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Mame_01499 ENOG4107U9H DNA polymerase Mame_01500 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Mame_01524 ENOG4107SVN transposase Mame_01529 ENOG4105ECQ AraC Family Transcriptional Regulator Mame_01535 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_01536 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter Mame_01537 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Mame_01540 ENOG4108MGI Transcriptional regulator Mame_01541 ENOG4105C1G acyl-Coa dehydrogenase Mame_01542 ENOG4105CPP Dehydrogenase, E1 component Mame_01543 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Mame_01549 ENOG4105CTX dehydratase Mame_01555 ENOG4105DHQ Histidine kinase Mame_01558 ENOG4105JSC dimethylmenaquinone methyltransferase Mame_01561 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Mame_01566 ENOG4105F5R ABC transporter Mame_01567 ENOG4105C2J ABC transporter Mame_01568 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) Mame_01572 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit Mame_01575 ENOG4105C0A alcohol dehydrogenase Mame_01576 ENOG4108IG5 Transcriptional regulator Mame_01578 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Mame_01580 ENOG4105CHU acetyl-coa acetyltransferase Mame_01583 ENOG4105C32 Amino acid ABC transporter (Permease) Mame_01584 ENOG4108IV0 ABC, transporter Mame_01585 ENOG4105C0Z ABC transporter Mame_01587 ENOG4105E39 Enoyl-CoA hydratase Mame_01588 ENOG4105CEY Amp-dependent synthetase and ligase Mame_01591 ENOG4105BZU Histidine kinase Mame_01594 ENOG4105C2J ABC transporter Mame_01595 ENOG4105CNN ABC, transporter Mame_01597 ENOG4108FN7 Aldo keto reductase Mame_01600 ENOG4105CMG Carbohydrate kinase Mame_01605 ENOG4105D5K Hemolysin activator protein Mame_01606 ENOG4105CKT filamentous hemagglutinin Mame_01609 ENOG4105CTD carboxy-peptidase Mame_01611 ENOG4105C3U ABC transporter Mame_01612 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_01614 ENOG4105DEF Extracellular solute-binding protein, family 5 Mame_01618 ENOG4105CHR reductase Mame_01620 ENOG4105D44 asparaginase Mame_01626 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A Mame_01628 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Mame_01629 ENOG4105C3M thioredoxin reductase Mame_01633 ENOG4105ETT transcriptional Regulator, LysR family Mame_01634 ENOG4108V1U phospholipid-binding protein Mame_01637 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Mame_01638 ENOG4108RPX mosc domain containing protein Mame_01639 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) Mame_01640 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein Mame_01641 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme Mame_01642 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) Mame_01643 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Mame_01644 ENOG4107R9N ABC transporter Mame_01645 ENOG4105C2J ABC transporter Mame_01647 ENOG4108WYP Transcriptional regulator Mame_01648 ENOG4105EGI Transcriptional regulator Mame_01649 ENOG4105EA8 2-Nitropropane dioxygenase Mame_01654 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Mame_01655 ENOG4108WUH Transcriptional regulator, TetR family Mame_01657 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) Mame_01661 ENOG4108JQ6 ABC transporter Mame_01662 ENOG41069H0 dihydroorotase EC 3.5.2.3 Mame_01667 ENOG4105E0A ABC, transporter Mame_01668 ENOG4105EHG Permease protein Mame_01670 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Mame_01681 ENOG4105VEQ Cold shock protein Mame_01682 ENOG4105ECK Fatty Acid Desaturase Mame_01688 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Mame_01697 ENOG4105DRS transport system, permease Mame_01702 ENOG4107YCY Transcriptional regulator Mame_01715 ENOG4105CMM transposase Mame_01716 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_01719 ENOG4106P55 Transcriptional regulator Mame_01720 ENOG4105CHM Aminotransferase Mame_01722 ENOG4105E7W lamb ycsf family protein Mame_01724 ENOG4107R7A Allophanate hydrolase subunit 2 Mame_01725 ENOG4105P4J Allophanate hydrolase, subunit 1 Mame_01726 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Mame_01729 ENOG4105CHR reductase Mame_01730 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Mame_01731 ENOG4105CPQ Dehydrogenase Mame_01732 ENOG4108JQ1 Dehydrogenase Mame_01734 ENOG4105MPN Membrane Mame_01735 ENOG4105D0S secretion protein (HlyD Mame_01736 ENOG4105CJ1 ABC, transporter Mame_01737 ENOG4105CMI transporter Mame_01738 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Mame_01739 ENOG4105CFG Acts as a chaperone (By similarity) Mame_01740 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Mame_01743 ENOG4108UHU Aldolase Mame_01744 ENOG41080ZE Adenylate cyclase Mame_01746 ENOG4105C72 UPF0176 protein Mame_01752 ENOG4105CN1 protease Mame_01754 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) Mame_01757 ENOG4107WK2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Mame_01758 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Mame_01759 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Mame_01760 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Mame_01765 ENOG4105K46 50S ribosomal protein l27 Mame_01766 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Mame_01771 ENOG4108C33 Resolvase Mame_01773 ENOG4107SCJ type I restriction enzyme EcoKI subunit R Mame_01781 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Mame_01783 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) Mame_01794 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Mame_01795 ENOG4108K3A Glutathione S-transferase Mame_01796 ENOG4105KVH Transcriptional regulator Mame_01802 ENOG4108JCI Transcriptional regulator Mame_01803 ENOG41090KR LysR family transcriptional Regulator Mame_01804 ENOG4105JSC dimethylmenaquinone methyltransferase Mame_01805 ENOG4105CHM Aminotransferase Mame_01806 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_01809 ENOG4105P4J Allophanate hydrolase, subunit 1 Mame_01810 ENOG4107R7A Allophanate hydrolase subunit 2 Mame_01813 ENOG4105ES4 Nitrilase Mame_01814 ENOG4107SQD Transcriptional regulator, GntR family Mame_01817 ENOG4105CMM transposase Mame_01819 ENOG4105CMM transposase Mame_01827 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Mame_01828 ENOG4108JE9 extracellular solute-binding protein family 1 Mame_01829 ENOG4105ETE Transcriptional regulator (LacI family Mame_01832 ENOG4105DG4 malate L-lactate dehydrogenase Mame_01837 ENOG4105DIA mandelate racemase muconate lactonizing Mame_01838 ENOG4105VMP Transcriptional regulator Mame_01841 ENOG4108JQ6 ABC transporter Mame_01842 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_01844 ENOG4108HIY periplasmic Mame_01846 ENOG4105C0A alcohol dehydrogenase Mame_01847 ENOG4107YCY Transcriptional regulator Mame_01848 ENOG4107S2N Type III effector Hrp-dependent Mame_01850 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Mame_01851 ENOG4108IG5 Transcriptional regulator Mame_01852 ENOG4105CC9 acyl-Coa dehydrogenase Mame_01853 ENOG4105C1G acyl-Coa dehydrogenase Mame_01854 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Mame_01855 ENOG4105C1G acyl-Coa dehydrogenase Mame_01856 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Mame_01860 ENOG4105EMY transcriptional regulator Mame_01861 ENOG4105EAM Na Pi-cotransporter Mame_01862 ENOG41060NJ transcriptional regulator Mame_01865 ENOG4105ECY inositol monophosphatase Mame_01866 ENOG4105ECY inositol monophosphatase Mame_01870 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_01871 ENOG4107RCV ABC transporter, permease Mame_01876 ENOG4105DB1 molybdopterin oxidoreductase Mame_01877 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Mame_01878 ENOG4108KDI dmso reductase anchor subunit Mame_01881 ENOG4105E0A ABC, transporter Mame_01882 ENOG4108IHU transport system permease protein Mame_01894 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) Mame_01895 ENOG4105FDP GntR family transcriptional regulator Mame_01897 ENOG4105CHR reductase Mame_01898 ENOG4105EF1 ribulokinase Mame_01900 ENOG4105CNN ABC, transporter Mame_01902 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Mame_01904 ENOG4105CPQ Dehydrogenase Mame_01905 ENOG4105ETE Transcriptional regulator (LacI family Mame_01906 ENOG4105F5H Glycosyl Hydrolase Family 88 Mame_01907 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) Mame_01911 ENOG4105DRS transport system, permease Mame_01912 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_01914 ENOG4105CHR reductase Mame_01915 ENOG4105FKQ transcriptional regulator Mame_01918 ENOG4105BZ7 extracellular solute-binding protein family 1 Mame_01919 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Mame_01925 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Mame_01927 ENOG4105C25 Primosomal protein n' Mame_01929 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Mame_01931 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Mame_01932 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Mame_01933 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Mame_01936 ENOG4105CKI cobalamin synthesis protein Mame_01937 ENOG4105ETE Transcriptional regulator (LacI family Mame_01941 ENOG4108Z86 Glutamine amidotransferase Mame_01942 ENOG4105CH5 extracellular solute-binding protein, family 7 Mame_01943 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_01949 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Mame_01950 ENOG4105W8H transhydrogenase (subunit alpha Mame_01951 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Mame_01958 ENOG4108Z18 K06886 hemoglobin Mame_01960 ENOG4105D2N Aldolase Mame_01961 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component Mame_01962 ENOG4105BZU Histidine kinase Mame_01965 ENOG4105DAY polysaccharide export protein Mame_01967 ENOG4105KPV Transcriptional regulator Mame_01968 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Mame_01970 ENOG4108MES Periplasmic binding protein Mame_01971 ENOG4105E0A ABC, transporter Mame_01972 ENOG4108IHU transport system permease protein Mame_01973 ENOG4105DQ5 transport system permease protein Mame_01974 ENOG4108MES Periplasmic binding protein Mame_01975 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Mame_01976 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Mame_01978 ENOG4105CBC glutamate synthase Mame_01979 ENOG4107QTZ amino acid Mame_01980 ENOG4105NWN ApaG protein Mame_01983 ENOG4105DHP deoxycytidine triphosphate deaminase Mame_01986 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Mame_01991 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Mame_01992 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Mame_01993 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Mame_01997 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Mame_02002 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Mame_02003 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Mame_02004 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) Mame_02005 ENOG4105WJX transcriptional regulator MERR family Mame_02007 ENOG4105CSR polyphosphate kinase 2 Mame_02010 ENOG4105E6M Sulphatase-modifying factor protein Mame_02011 ENOG4105CMQ Chloride channel Mame_02013 ENOG4105W6J BA14K family Mame_02015 ENOG4108KPJ rna polymerase sigma factor Mame_02016 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Mame_02018 ENOG4108JCI Transcriptional regulator Mame_02019 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Mame_02020 ENOG4108JU6 CBS domain protein Mame_02021 ENOG4105D49 3-dehydroquinate synthase Mame_02022 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Mame_02023 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Mame_02024 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) Mame_02026 ENOG4105VFE sira family Mame_02027 ENOG4105CKI cobalamin synthesis protein Mame_02028 ENOG4105DZ1 carboxypeptidase Mame_02029 ENOG4105CH2 amidohydrolase Mame_02031 ENOG4105S10 periplasmic binding protein Mame_02032 ENOG4105EHG Permease protein Mame_02033 ENOG4108W0P ABC transporter Mame_02039 ENOG4105D0C transport protein Mame_02042 ENOG4108MI0 Resistance protein Mame_02043 ENOG4105J12 Multidrug resistance protein mdtN Mame_02046 ENOG4105CI2 imidazolone-5-propionate hydrolase Mame_02048 ENOG4105CJW magnesium transporter Mame_02049 ENOG4105CVK Glutamate decarboxylase Mame_02050 ENOG4105WH1 Two component transcriptional regulator luxr family Mame_02053 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_02056 ENOG4105MRR Transcriptional regulator (By similarity) Mame_02058 ENOG4108YZ9 Urea amidohydrolase subunit gamma Mame_02060 ENOG4105CQM Urea amidohydrolase subunit alpha Mame_02061 ENOG4108VDS Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) Mame_02062 ENOG4107Z51 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Mame_02063 ENOG4107UHB Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) Mame_02064 ENOG4108XNJ Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Mame_02066 ENOG4105BZU Histidine kinase Mame_02070 ENOG4105D0C transport protein Mame_02073 ENOG4107TJ9 Cytochrome Mame_02074 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Mame_02075 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Mame_02076 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) Mame_02081 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Mame_02082 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Mame_02083 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) Mame_02085 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Mame_02088 ENOG4105E33 succinate dehydrogenase Mame_02089 ENOG4105YU5 Outer membrane lipoprotein Mame_02090 ENOG4105D6Z AFG1 family ATPase Mame_02091 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Mame_02092 ENOG4105CMV Succinyl-CoA synthetase subunit beta Mame_02093 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Mame_02094 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Mame_02095 ENOG4105C7S Dehydrogenase Mame_02098 ENOG4107QN2 dihydrolipoyl dehydrogenase Mame_02101 ENOG4107EFR Flavocytochrome c Mame_02102 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Mame_02103 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Mame_02107 ENOG4105CMT Dihydroxyacetone kinase Mame_02108 ENOG4108UTZ Dihydroxyacetone kinase Mame_02109 ENOG4105CMT Dihydroxyacetone kinase Mame_02110 ENOG4108R85 Short chain dehydrogenase Mame_02111 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Mame_02112 ENOG4105CNN ABC, transporter Mame_02113 ENOG4105C2J ABC transporter Mame_02116 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Mame_02118 ENOG4105CJ2 (LipO)protein Mame_02120 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) Mame_02121 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) Mame_02122 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) Mame_02133 ENOG4105CHR reductase Mame_02144 ENOG4107Z1W Fructose transport system kinase Mame_02145 ENOG4105C26 Dehydrogenase Mame_02146 ENOG4105EW9 transcriptional regulator AsnC family Mame_02150 ENOG4105EDK PfkB domain protein Mame_02151 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) Mame_02153 ENOG4105DH8 myo-inositol catabolism Mame_02155 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Mame_02158 ENOG4108RIR Molybdenum cofactor biosynthesis protein Mame_02159 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Mame_02161 ENOG4105EAH synthase Mame_02166 ENOG4105CK7 Sodium proline symporter Mame_02168 ENOG4108V0P LemA family Mame_02169 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Mame_02172 ENOG4105C38 Glycyl-tRNA synthetase beta subunit Mame_02173 ENOG410600T transposase Mame_02176 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Mame_02177 ENOG4105BZM domain protein Mame_02178 ENOG4105C12 Phosphoribosylglycinamide synthetase Mame_02179 ENOG4105CNU cell division protein FtsK Mame_02180 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) Mame_02181 ENOG4105CGK Exodeoxyribonuclease III Mame_02183 ENOG41086Q3 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) Mame_02184 ENOG4108Z03 MAF-like protein Mame_02185 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Mame_02186 ENOG4108ZTZ UPF0262 protein Mame_02187 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Mame_02189 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Mame_02198 ENOG4105CHH sulfate transporter Mame_02199 ENOG4105FDF Could be involved in DNA repair (By similarity) Mame_02200 ENOG4105DQE DNA ligase Mame_02201 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Mame_02202 ENOG4107ZT5 Thiol disulfide interchange protein Mame_02203 ENOG4105CH7 arginosuccinase Mame_02204 ENOG4107SVN transposase Mame_02206 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Mame_02209 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Mame_02210 ENOG4108UGV hypoxanthine phosphoribosyltransferase Mame_02211 ENOG4105CAK Cell division ATP-binding protein ftsE Mame_02215 ENOG4108NH8 Cation transport protein Mame_02218 ENOG4105CIH Imidazole acetol-phosphate transaminase Mame_02219 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Mame_02220 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Mame_02224 ENOG4105KDC 50s ribosomal protein l28 Mame_02225 ENOG4105EX9 Membrane Mame_02226 ENOG4105DEI Mannitol dehydrogenase Mame_02227 ENOG4105E5K Alpha-amylase Mame_02235 ENOG4108E2B had-superfamily hydrolase, subfamily iib Mame_02236 ENOG4107STW synthase Mame_02239 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Mame_02240 ENOG4105YVM Phosphoesterase, PA-phosphatase related Mame_02241 ENOG4105YVM Phosphoesterase, PA-phosphatase related Mame_02242 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Mame_02243 ENOG4108V9Q carbonic anhydrase Mame_02245 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Mame_02247 ENOG4107QNJ CoA-transferase subunit B Mame_02248 ENOG4105DDW LysR family Transcriptional regulator Mame_02249 ENOG4105F2Z 3-oxoadipate enol-lactonase Mame_02250 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase Mame_02251 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta Mame_02252 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha Mame_02255 ENOG4107S9B Shikimate dehydrogenase Mame_02256 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase Mame_02258 ENOG4108ERU trap dicarboxylate transporter subunit DctP Mame_02259 ENOG4108ERU trap dicarboxylate transporter subunit DctP Mame_02260 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ Mame_02261 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_02262 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Mame_02263 ENOG4105E1F short-chain dehydrogenase reductase Mame_02271 ENOG4108594 Permease of the drug metabolite transporter Mame_02273 ENOG4108XFH Transcriptional regulator Mame_02274 ENOG4107Z3H Transcriptional regulator, TetR family Mame_02276 ENOG4105EMU Dehydrogenase Mame_02278 ENOG4105D3W isochorismatase Mame_02280 ENOG4105CHR reductase Mame_02281 ENOG4105CF7 AraC family transcriptional regulator Mame_02284 ENOG4107B2H carbonic anhydrase Mame_02285 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) Mame_02286 ENOG4105C7I Dehydrogenase Mame_02288 ENOG4105DC1 bifunctional purine biosynthesis protein purh Mame_02290 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Mame_02291 ENOG4105D0M Protease HtpX homolog Mame_02295 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_02297 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Mame_02298 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Mame_02303 ENOG4105C01 Dihydroxy-acid dehydratase Mame_02304 ENOG4105C6Y Udp-glucose 6-dehydrogenase Mame_02305 ENOG4105KZJ alginate biosynthesis protein Alg8 Mame_02307 ENOG4105CJT Mannose-1-phosphate guanylyltransferase Mame_02308 ENOG4108C0K Bifunctional protein that converts poly(beta-D- mannuronate) to alpha-L-guluronate and that is also part of a periplasmic protein complex that serves as a scaffold that leads the newly formed alginate polymer through the periplasmic space to the outer membrane secretin AlgE Mame_02319 ENOG4105ETE Transcriptional regulator (LacI family Mame_02321 ENOG4107YM4 Beta-lactamase domain-containing protein Mame_02323 ENOG4105C4Y ABC transporter Mame_02324 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_02325 ENOG4107RSM transcriptional regulator Mame_02332 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) Mame_02333 ENOG4105CPQ Dehydrogenase Mame_02336 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Mame_02337 ENOG4105TAV cytochrome C Mame_02338 ENOG4105DWF phosphomethylpyrimidine kinase Mame_02339 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Mame_02340 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase Mame_02342 ENOG4105C26 Dehydrogenase Mame_02343 ENOG4105JQN Transcriptional regulator Mame_02346 ENOG4105BZA Phosphoglycerate kinase Mame_02347 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) Mame_02349 ENOG4105CAS nag kinase Mame_02353 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Mame_02354 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Mame_02356 ENOG4105BZU Histidine kinase Mame_02359 ENOG4105BZU Histidine kinase Mame_02360 ENOG4105C3Q Glycosyl transferase, family 2 Mame_02361 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase Mame_02362 ENOG4105C2N RNA methyltransferase TrmH family group 3 Mame_02365 ENOG4105BZU Histidine kinase Mame_02366 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Mame_02368 ENOG4105VZ8 Transcriptional regulator Mame_02372 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Mame_02373 ENOG4107T8T UPF0173 metal-dependent hydrolase Mame_02374 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Mame_02376 ENOG4105DR5 peptidase Mame_02377 ENOG4108FUF Transcriptional regulator, IclR family Mame_02378 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_02381 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) Mame_02382 ENOG4105HM0 Sulfoacetaldehyde acetyltransferase Mame_02383 ENOG4108IJ2 phosphate acetyltransferase Mame_02386 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Mame_02387 ENOG4105C57 major facilitator superfamily Mame_02393 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Mame_02396 ENOG4105FEU K -dependent Na -Ca exchanger Mame_02397 ENOG4108K3A Glutathione S-transferase Mame_02398 ENOG4107QI1 Mate efflux family protein Mame_02399 ENOG4105C9Q fumarate hydratase class II Mame_02401 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Mame_02402 ENOG4105E66 phosphoriboisomerase A Mame_02407 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase Mame_02408 ENOG4105C4K Nad synthetase Mame_02409 ENOG4108MR6 WD40-like Beta Propeller Repeat Mame_02412 ENOG4105DHJ ABC, transporter Mame_02415 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 Mame_02416 ENOG4105ECP epimerase Mame_02419 ENOG4107YD3 Thioesterase Mame_02420 ENOG4105E02 MotA TolQ exbB proton channel Mame_02421 ENOG4105M8F Biopolymer transport protein exbD tolR Mame_02423 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) Mame_02424 ENOG4105KCK Peptidoglycan-associated lipoprotein Mame_02426 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Mame_02427 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Mame_02428 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Mame_02433 ENOG4108JQ1 Dehydrogenase Mame_02434 ENOG4105BZU Histidine kinase Mame_02437 ENOG4105YCT UPF0386 protein Mame_02438 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Mame_02440 ENOG410870W N-acetyltransferase Mame_02443 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) Mame_02444 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Mame_02446 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Mame_02449 ENOG4105C03 ribonuclease Mame_02449 ENOG4105C03 ribonuclease Mame_02450 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Mame_02452 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) Mame_02454 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) Mame_02459 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Mame_02461 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Mame_02462 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) Mame_02466 ENOG4108206 Cell division protein mraZ Mame_02467 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Mame_02470 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Mame_02472 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Mame_02473 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Mame_02475 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Mame_02476 ENOG4105DFU Cell wall formation (By similarity) Mame_02477 ENOG410600T transposase Mame_02478 ENOG4105CPF Cell wall formation (By similarity) Mame_02479 ENOG4108UFP Essential cell division protein (By similarity) Mame_02480 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Mame_02481 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Mame_02482 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Mame_02483 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Mame_02484 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Mame_02485 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Mame_02487 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Mame_02489 ENOG4108Y50 Glutathione-dependent formaldehyde-activating Gfa Mame_02491 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Mame_02492 ENOG4105ECQ AraC Family Transcriptional Regulator Mame_02499 ENOG4105CQB FAD linked oxidase domain protein Mame_02501 ENOG4105WD1 Membrane Mame_02504 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Mame_02505 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Mame_02506 ENOG4108IJ9 (ABC) transporter Mame_02508 ENOG4105EPC oxidoreductase Mame_02510 ENOG4105CPC Aldo Keto reductase Mame_02512 ENOG4105FDK ABC transporter Mame_02513 ENOG4105FAV ABC, transporter Mame_02516 ENOG4108Z0R Transferase Mame_02517 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase Mame_02518 ENOG4105BZU Histidine kinase Mame_02519 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Mame_02520 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Mame_02521 ENOG4105CSV Glutaminase Mame_02522 ENOG4105NTW Transcriptional regulator Mame_02524 ENOG4105KHC sulfurtransferase Mame_02527 ENOG4105CVP deoxyribo-dipyrimidine photolyase Mame_02528 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein Mame_02541 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) Mame_02542 ENOG4107QRI Phosphoketolase Mame_02543 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Mame_02546 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) Mame_02548 ENOG4105QEK Transcriptional regulator Mame_02551 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_02552 ENOG4105CH5 extracellular solute-binding protein, family 7 Mame_02553 ENOG4105C5F glutamine synthetase Mame_02554 ENOG4105C26 Dehydrogenase Mame_02559 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Mame_02561 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Mame_02595 ENOG4105CF2 Mu-like prophage FluMu protein GP28 Mame_02611 ENOG4108WTW DNA transposition protein Mame_02612 ENOG4106YXT transposase Mame_02621 ENOG4105NI8 Cytosine-specific methyltransferase Mame_02628 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase Mame_02630 ENOG410802X bacteriophage n4 adsorption protein b Mame_02632 ENOG4105QVC MOSC domain-containing protein Mame_02633 ENOG4105D64 Mechanosensitive ion channel Mame_02635 ENOG4108R7K Metal Dependent Phosphohydrolase Mame_02636 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Mame_02638 ENOG4105M6F mutator MutT protein Mame_02640 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase Mame_02641 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme Mame_02642 ENOG4108JJ7 ABC transporter Mame_02644 ENOG4108URH decarboxylase Mame_02646 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Mame_02650 ENOG4105C8N cysteinyl-tRNA synthetase Mame_02655 ENOG4105UBK short-chain dehydrogenase reductase Mame_02656 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase Mame_02659 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Mame_02660 ENOG4105CDU Replicative dna helicase Mame_02662 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Mame_02664 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Mame_02665 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Mame_02669 ENOG4105CPC Aldo Keto reductase Mame_02670 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Mame_02672 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Mame_02673 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Mame_02674 ENOG4105HHA aminodeoxychorismate lyase Mame_02675 ENOG4105DSJ YicC domain protein Mame_02676 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Mame_02677 ENOG4105CBG Sulfatase Mame_02678 ENOG4108KPW sugar kinase Mame_02679 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_02684 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Mame_02686 ENOG4105C0B DNA polymerase III (alpha subunit) Mame_02689 ENOG4108UQD Sel1 domain protein repeat-containing protein Mame_02691 ENOG4105C2W permease Mame_02692 ENOG4108YX9 iron--sulfur cluster insertion protein erpA Mame_02693 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Mame_02694 ENOG4105C75 arginyL-tRNA synthetase Mame_02696 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Mame_02697 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Mame_02698 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Mame_02699 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_02700 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Mame_02702 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Mame_02710 ENOG4105UIB (ABC) transporter Mame_02711 ENOG4108JQ9 ABC transporter Mame_02714 ENOG4108RXX maleylacetoacetate isomerase Mame_02719 ENOG4107RIZ hflk protein Mame_02723 ENOG4108YYQ gCN5-related N-acetyltransferase Mame_02724 ENOG4105EAC phosphoserine phosphatase Mame_02725 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Mame_02726 ENOG4105C7K acetolactate synthase Mame_02727 ENOG4108ZP8 Acetolactate synthase small subunit Mame_02730 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Mame_02732 ENOG4105NAU thioesterase Superfamily protein Mame_02734 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Mame_02737 ENOG4105DU6 RNA polymerase Mame_02739 ENOG4107SID ATP-dependent exodnase (exonuclease v) Mame_02740 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) Mame_02741 ENOG4105ECR NmrA family Mame_02742 ENOG4105KVH Transcriptional regulator Mame_02744 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Mame_02745 ENOG4105VR9 phosphoribosylformylglycinamidine synthase Mame_02746 ENOG4107QPR SAICAR synthetase Mame_02748 ENOG4105CVM Molybdenum cofactor synthesis domain protein Mame_02749 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Mame_02751 ENOG4108I0Q anthranilate phosphoribosyltransferase Mame_02755 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase Mame_02756 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Mame_02758 ENOG4108JYK Dehydrogenase Mame_02759 ENOG4105CPP Dehydrogenase, E1 component Mame_02760 ENOG4105C7S Dehydrogenase Mame_02763 ENOG4107QN2 dihydrolipoyl dehydrogenase Mame_02765 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Mame_02766 ENOG41082CG Protein CrcB homolog Mame_02767 ENOG4105EI2 Pseudouridine synthase Mame_02768 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Mame_02770 ENOG4105C4W S-formylglutathione hydrolase Mame_02771 ENOG4108UPT UPF0178 protein Mame_02773 ENOG4107QPD alcohol dehydrogenase Mame_02775 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Mame_02777 ENOG4105EN6 Membrane Mame_02778 ENOG4105CNN ABC, transporter Mame_02780 ENOG4105CNN ABC, transporter Mame_02782 ENOG4105C2J ABC transporter Mame_02783 ENOG4105H9W Short-chain dehydrogenase reductase Sdr Mame_02786 ENOG4108IUZ ABC transporter Mame_02787 ENOG4108IV0 ABC, transporter Mame_02795 ENOG4108WYP Transcriptional regulator Mame_02802 ENOG4105DS0 Transcriptional regulator, Crp Fnr family Mame_02803 ENOG4105D4P Coproporphyrinogen iii oxidase Mame_02804 ENOG4105J3Q acyl carrier protein Mame_02807 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Mame_02811 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Mame_02812 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Mame_02818 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) Mame_02819 ENOG4105C8Y Acetylornithine aminotransferase Mame_02820 ENOG4105C26 Dehydrogenase Mame_02821 ENOG4108RYR transcriptional regulator AsnC family Mame_02822 ENOG4107SQD Transcriptional regulator, GntR family Mame_02823 ENOG4108KJ1 Trap dicarboxylate transporter, dctp subunit Mame_02824 ENOG4108K1J Transporter DctQ Mame_02825 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_02826 ENOG41080TK Universal stress protein Mame_02830 ENOG4105ENR peptidase, M24 Mame_02831 ENOG4105CPQ Dehydrogenase Mame_02832 ENOG4105CMG Carbohydrate kinase Mame_02833 ENOG4106P19 photosystem i assembly btpa Mame_02834 ENOG4105E98 transcriptional regulator DeoR family Mame_02837 ENOG4105DRS transport system, permease Mame_02840 ENOG4105E1J oxidoreductase Mame_02848 ENOG4107RUE extracellular solute-binding protein family 1 Mame_02849 ENOG4105F38 ABC transporter, permease Mame_02852 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) Mame_02854 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Mame_02855 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Mame_02856 ENOG4105EXW epimerase dehydratase Mame_02857 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Mame_02862 ENOG4108I5U Uridine phosphorylase Mame_02863 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_02867 ENOG4105KPV Transcriptional regulator Mame_02873 ENOG4107ENK receptor Mame_02878 ENOG4108IG5 Transcriptional regulator Mame_02879 ENOG4105E0K tonB-dependent siderophore receptor Mame_02889 ENOG4105EQ0 Major Facilitator superfamily Mame_02892 ENOG4105C2I pirin domain protein Mame_02893 ENOG4105FBA Phospholipase Carboxylesterase Mame_02894 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase Mame_02896 ENOG4108YYH Nadph-dependent fmn reductase Mame_02897 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Mame_02898 ENOG4108XHQ (2Fe-2S)-binding domain protein Mame_02899 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Mame_02901 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Mame_02904 ENOG4105ID8 Transcriptional regulator, ARAC family Mame_02908 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit Mame_02909 ENOG4108ZXC Two component transcriptional regulator, luxr family Mame_02910 ENOG4105EYW Ion transport protein Mame_02912 ENOG4108ZXC Two component transcriptional regulator, luxr family Mame_02913 ENOG4108ZXC Two component transcriptional regulator, luxr family Mame_02914 ENOG4105BZU Histidine kinase Mame_02916 ENOG4105EFZ amidohydrolase Mame_02922 ENOG4105K6T rare lipoprotein A Mame_02923 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Mame_02925 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Mame_02926 ENOG4105F8V Hydrolase, tatD family Mame_02927 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Mame_02928 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_02930 ENOG4105F38 ABC transporter, permease Mame_02934 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Mame_02937 ENOG4105K6V RNA polymerase Mame_02938 ENOG4108NIX Factor ChrR Mame_02942 ENOG4108KK1 membrane protein AbrB duplication Mame_02945 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Mame_02946 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Mame_02947 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Mame_02949 ENOG4108Z1B Cyclase dehydrase Mame_02950 ENOG4107TH8 cina domain protein Mame_02951 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Mame_02953 ENOG4105CUX Signal transduction histidine kinase Mame_02954 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Mame_02955 ENOG4105ES5 Histidine kinase Mame_02956 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Mame_02957 ENOG4105C1A potassium transporter peripheral membrane Mame_02958 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Mame_02959 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Mame_02960 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase Mame_02961 ENOG4105VUF Transcriptional regulator Mame_02962 ENOG4105DXN mazG family Mame_02964 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Mame_02966 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) Mame_02968 ENOG4105DP0 ferredoxin-NADP reductase Mame_02969 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Mame_02970 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Mame_02971 ENOG4105ENT Efflux transporter rnd family, mfp subunit Mame_02972 ENOG4105PS1 invasion associated locus B Mame_02974 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Mame_02975 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Mame_02977 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Mame_02978 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Mame_02980 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein Mame_02981 ENOG4108UUM single-stranded DNA-binding protein Mame_02982 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Mame_02984 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Mame_02986 ENOG4105C5F glutamine synthetase Mame_02990 ENOG4107ZXU DSBA oxidoreductase Mame_02991 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Mame_02993 ENOG4107NKQ Flavinator of succinate dehydrogenase Mame_02994 ENOG4105CB5 ATP-dependent DNA helicase recG Mame_02997 ENOG410600T transposase Mame_02999 ENOG4105KST dependent repressor Mame_03000 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) Mame_03001 ENOG41062JF Transcriptional regulator Mame_03002 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Mame_03004 ENOG4105C9U ATP-dependent DNA helicase RecQ Mame_03007 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Mame_03008 ENOG4108UJD 30S ribosomal protein S9 Mame_03010 ENOG4108PVQ transcriptional regulator Mame_03013 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Mame_03015 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Mame_03018 ENOG4105D64 Mechanosensitive ion channel Mame_03021 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B Mame_03022 ENOG4105DEF Extracellular solute-binding protein, family 5 Mame_03024 ENOG4108JQ6 ABC transporter Mame_03031 ENOG4105CHU acetyl-coa acetyltransferase Mame_03034 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Mame_03035 ENOG4108IJ7 Glycine betaine Mame_03036 ENOG4108HQS Glycine betaine Mame_03037 ENOG4105GIJ Glycine betaine Mame_03038 ENOG4105C54 Major Facilitator superfamily Mame_03039 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Mame_03041 ENOG4105C7B Threonine dehydratase Mame_03042 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Mame_03044 ENOG4105BZU Histidine kinase Mame_03045 ENOG4105K70 DNA-binding protein Mame_03046 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Mame_03047 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Mame_03048 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Mame_03049 ENOG4106KTS Inner membrane protein yeaI Mame_03052 ENOG4105K4P CoA-binding domain protein Mame_03055 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) Mame_03056 ENOG4105C8U phosphate abc transporter Mame_03057 ENOG4105E2Z phosphate ABC transporter (Permease Mame_03058 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Mame_03061 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Mame_03062 ENOG4108QIF Phosphoesterase, PA-phosphatase related Mame_03067 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) Mame_03068 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Mame_03069 ENOG4107UIS Involved in DNA repair and RecF pathway recombination (By similarity) Mame_03070 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Mame_03071 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Mame_03072 ENOG4105C3F Signal peptidase i Mame_03073 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Mame_03077 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Mame_03079 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Mame_03080 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Mame_03081 ENOG4107SC1 transglycosylase Mame_03085 ENOG4105VEQ Cold shock protein Mame_03086 ENOG4108UYE Lactoylglutathione lyase Mame_03089 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Mame_03090 ENOG4105D6E homoserine dehydrogenase Mame_03091 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Mame_03093 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Mame_03094 ENOG4105CHM Aminotransferase Mame_03097 ENOG4105PW4 Sugar fermentation stimulation protein homolog Mame_03098 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Mame_03099 ENOG4105W5Q DNA repair protein (RadC Mame_03103 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Mame_03105 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Mame_03111 ENOG4105CMM transposase Mame_03114 ENOG4105CMM transposase Mame_03115 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Mame_03119 ENOG4105F5W AtP-binding protein Mame_03125 ENOG4105BZU Histidine kinase Mame_03126 ENOG4105RK9 auxin efflux carrier Mame_03127 ENOG4107QIV Cytochrome c biogenesis protein Mame_03132 ENOG4105JAB phenazine biosynthesis protein, phzf family Mame_03139 ENOG4105C2J ABC transporter Mame_03140 ENOG4105VE1 Phosphatidylcholine synthase Mame_03142 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Mame_03144 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Mame_03147 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) Mame_03154 ENOG41080HT Transcriptional regulator, arsr family Mame_03155 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Mame_03158 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) Mame_03166 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Mame_03167 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 Mame_03168 ENOG4105BZN citrate synthase Mame_03169 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Mame_03171 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Mame_03172 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Mame_03173 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Mame_03174 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Mame_03175 ENOG4105DZP Membrane-associated zinc metalloprotease Mame_03177 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Mame_03178 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Mame_03179 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Mame_03180 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Mame_03181 ENOG4105CE9 30S ribosomal protein S2 Mame_03186 ENOG4105K59 histidine triad (HIT) protein Mame_03187 ENOG4105KT7 mgtC SapB transporter Mame_03188 ENOG4106D4I domain protein Mame_03189 ENOG4107VRP DNA repair exonuclease Mame_03190 ENOG4107SET aldo keto reductase Mame_03192 ENOG4108SXK Transporter Drug Metabolite Exporter family Mame_03193 ENOG4105HEI LysR family (Transcriptional regulator Mame_03194 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase Mame_03195 ENOG4105FBA Phospholipase Carboxylesterase Mame_03196 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) Mame_03198 ENOG4108JQ6 ABC transporter Mame_03199 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_03200 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Mame_03201 ENOG4105DEF Extracellular solute-binding protein, family 5 Mame_03202 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate Mame_03203 ENOG4106G6Q Transcriptional regulator Mame_03205 ENOG4105CHH sulfate transporter Mame_03206 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Mame_03207 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Mame_03208 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Mame_03212 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) Mame_03214 ENOG4108IV0 ABC, transporter Mame_03215 ENOG4105C0Z ABC transporter Mame_03217 ENOG4105C32 Amino acid ABC transporter (Permease) Mame_03219 ENOG4105EMY transcriptional regulator Mame_03222 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Mame_03223 ENOG4108JQ6 ABC transporter Mame_03224 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_03225 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Mame_03227 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) Mame_03228 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme Mame_03231 ENOG4105DJP Membrane Mame_03236 ENOG4105CBG Sulfatase Mame_03237 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_03239 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Mame_03241 ENOG410811B TRANSCRIPTIONal Mame_03243 ENOG4105BZU Histidine kinase Mame_03246 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Mame_03247 ENOG4105E0F Histidine kinase Mame_03249 ENOG4105CHR reductase Mame_03250 ENOG4105CJP fad dependent oxidoreductase Mame_03252 ENOG4105ETT transcriptional Regulator, LysR family Mame_03255 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) Mame_03257 ENOG4105DRP amino acid AbC transporter Mame_03258 ENOG4105CDA abc transporter atp-binding protein Mame_03260 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Mame_03262 ENOG4108YZ4 nudix hydrolase Mame_03263 ENOG4105D6S protein involved in catabolism of external DNA Mame_03264 ENOG4108U78 Glutathione S-transferase Mame_03265 ENOG4105JVC membrAne Mame_03266 ENOG4105CHR reductase Mame_03267 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Mame_03269 ENOG4105M00 molybdopterin converting factor, subunit 1 Mame_03270 ENOG4108ZAF Molybdopterin Mame_03272 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Mame_03275 ENOG4105C5H ABC transporter Mame_03276 ENOG4105SYT Methylenetetrahydrofolate reductase Mame_03278 ENOG4105DR5 peptidase Mame_03279 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Mame_03280 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Mame_03281 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Mame_03282 ENOG4105DEF Extracellular solute-binding protein, family 5 Mame_03287 ENOG41080HI glycine oxidase Mame_03289 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_03290 ENOG4108JQ6 ABC transporter Mame_03292 ENOG4105C2J ABC transporter Mame_03293 ENOG4105CNN ABC, transporter Mame_03294 ENOG4105CMT Dihydroxyacetone kinase Mame_03297 ENOG4107SS6 2-dehydro-3-deoxygluconokinase Mame_03299 ENOG4106IQC argininosuccinate lyase Mame_03300 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Mame_03302 ENOG4107FKK extracellular solute-binding protein family 1 Mame_03303 ENOG4107TFG D-allose kinase Mame_03308 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family Mame_03310 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Mame_03313 ENOG4105C26 Dehydrogenase Mame_03317 ENOG4105C3R Methionine synthase Mame_03318 ENOG4107QKS N-acylglucosamine 2-epimerase Mame_03319 ENOG4107SQ0 N-acetyl-gamma-glutamyl-phosphate reductase Mame_03321 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Mame_03322 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Mame_03323 ENOG4105C8S subunit m Mame_03324 ENOG4105D65 subunit l Mame_03325 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Mame_03326 ENOG4105DF2 NADH dehydrogenase subunit j Mame_03327 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Mame_03328 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Mame_03329 ENOG4107R0R NADH dehydrogenase subunit g Mame_03331 ENOG4107QIZ NADH dehydrogenase Mame_03332 ENOG4105GKE subunit e Mame_03333 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Mame_03334 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Mame_03335 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Mame_03336 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Mame_03341 ENOG4105C7B Threonine dehydratase Mame_03342 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) Mame_03343 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii Mame_03346 ENOG4105C2C drug resistance transporter, Bcr CflA Mame_03348 ENOG4105CHR reductase Mame_03350 ENOG4105ECY inositol monophosphatase Mame_03351 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Mame_03353 ENOG4105DCF alanine dehydrogenase Mame_03354 ENOG4108YXU transcriptional regulator AsnC family Mame_03356 ENOG4105CGH 5'-nucleotidase Mame_03360 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters Mame_03362 ENOG4105CM6 amino acid regulated cytosolic protein Mame_03363 ENOG4106K28 UPF0283 membrane protein Mame_03365 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Mame_03366 ENOG4105KRF dihydroneopterin aldolase Mame_03368 ENOG4107Z7P Ferredoxin Mame_03371 ENOG4105D98 threonine synthase Mame_03374 ENOG4105BZU Histidine kinase Mame_03376 ENOG4108UJU UPF0301 protein Mame_03381 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Mame_03382 ENOG4105CUV Homoserine Kinase Mame_03383 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Mame_03385 ENOG4108R6F Surfeit locus 1 family protein Mame_03388 ENOG4107QS1 Cytochrome C Oxidase, Subunit III Mame_03389 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) Mame_03391 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Mame_03392 ENOG4105BZ9 Cytochrome C oxidase, subunit I Mame_03393 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) Mame_03395 ENOG4105D1U peptidase U62 modulator of DNA gyrase Mame_03398 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Mame_03400 ENOG41090KN UPF0303 protein Mame_03401 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) Mame_03402 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Mame_03403 ENOG4105CVJ phosphoglycerate mutase Mame_03404 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Mame_03408 ENOG4105W0E 50S ribosomal protein L33 Mame_03409 ENOG4105CKD glutathione-regulated potassium-efflux system protein Mame_03413 ENOG4105F7P transcriptional regulator AsnC family Mame_03414 ENOG4105C3M thioredoxin reductase Mame_03415 ENOG4105CBN LysR family transcriptional regulator Mame_03416 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Mame_03419 ENOG4108M0I Transcriptional regulator Mame_03421 ENOG4105CHM Aminotransferase Mame_03423 ENOG4105D8V Glucose sorbosone dehydrogenase Mame_03426 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Mame_03427 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Mame_03429 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Mame_03433 ENOG4105EWV Sodium calcium exchanger membrane region Mame_03435 ENOG4105V5Z Iron-sulfur cluster assembly accessory protein Mame_03436 ENOG4105VG1 fes assembly suf system protein Mame_03437 ENOG4105C9B Cysteine desulfurase Mame_03438 ENOG4105JRK feS assembly protein SufD Mame_03442 ENOG4105C3J Cysteine desulfurase Mame_03443 ENOG4105DHZ alpha beta Mame_03446 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Mame_03448 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Mame_03449 ENOG4105C1J atp-dependent rna helicase Mame_03450 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) Mame_03452 ENOG4105DJV ribulose-phosphate 3-epimerase Mame_03454 ENOG4105C83 adenylosuccinate lyase Mame_03457 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Mame_03459 ENOG4105CP7 Triose-phosphate isomerase Mame_03460 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Mame_03464 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein Mame_03468 ENOG4107XC4 flavin reductase domain protein, FMN-binding Mame_03471 ENOG4107J0A lipopolysaccharide biosynthetic process Mame_03472 ENOG4107J0A lipopolysaccharide biosynthetic process Mame_03473 ENOG4105C22 threonyL-tRNA synthetase Mame_03475 ENOG4108XM1 transcriptional regulator AsnC family Mame_03476 ENOG4108RG0 uracil-dna glycosylase Mame_03477 ENOG4105BZU Histidine kinase Mame_03479 ENOG41085FU Diacylglycerol kinase Mame_03480 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) Mame_03481 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) Mame_03483 ENOG4105HF0 Membrane Mame_03485 ENOG4105D7W serine acetyltransferase Mame_03490 ENOG4105C28 cystathionine Mame_03491 ENOG4107QXX ABC transporter Mame_03492 ENOG4105EZ7 amino acid ABC transporter Mame_03493 ENOG4105DRP amino acid AbC transporter Mame_03494 ENOG4105CDA abc transporter atp-binding protein Mame_03499 ENOG41082FS 50S ribosomal protein L31 Mame_03500 ENOG4105BZ1 (ABC) transporter Mame_03501 ENOG4108SXK Transporter Drug Metabolite Exporter family Mame_03503 ENOG4105UYK outer membrane protein a Mame_03505 ENOG4105ECY inositol monophosphatase Mame_03506 ENOG4105BZU Histidine kinase Mame_03510 ENOG4105Y2X UPF0335 protein Mame_03514 ENOG4105CA9 Pyruvate kinase Mame_03515 ENOG4107SVN transposase Mame_03517 ENOG4105EJQ L-serine dehydratase Mame_03522 ENOG4105CJW magnesium transporter Mame_03523 ENOG4105BZU Histidine kinase Mame_03525 ENOG4105CIH Imidazole acetol-phosphate transaminase Mame_03526 ENOG4105CYM Glutathione S-transferase Mame_03527 ENOG4105FYV Amp nucleosidase Mame_03529 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase Mame_03537 ENOG4105CD8 aminopeptidase N Mame_03539 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) Mame_03540 ENOG4106F60 Histidine kinase Mame_03541 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Mame_03542 ENOG4105C0H protease Mame_03543 ENOG4105KWW Biogenesis protein Mame_03544 ENOG4105DA4 cytochrome c-type biogenesis protein Mame_03545 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) Mame_03546 ENOG4106FI7 cytochrome c-type biogenesis protein Mame_03548 ENOG4105DHQ Histidine kinase Mame_03549 ENOG4105XJC Two component transcriptional regulator (Winged helix family Mame_03568 ENOG4108ZZ3 UPF0260 protein Mame_03570 ENOG4105C32 Amino acid ABC transporter (Permease) Mame_03571 ENOG4105UIB (ABC) transporter Mame_03572 ENOG4105C0Z ABC transporter Mame_03573 ENOG4108IV0 ABC, transporter Mame_03579 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) Mame_03581 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Mame_03582 ENOG4108YXV Transcriptional regulator Mame_03583 ENOG4105KJM monovalent cation h antiporter subunit g Mame_03584 ENOG41080TA Multiple resistance and ph regulation protein f Mame_03585 ENOG4105SC1 monovalent cation H antiporter subunit E Mame_03586 ENOG4108JPZ Monovalent cation H antiporter subunit D Mame_03587 ENOG4108ZE9 Monovalent cation H antiporter subunit C Mame_03588 ENOG4105HC0 Na H antiporter Mame_03589 ENOG4105D65 subunit l Mame_03590 ENOG4105E0X reductase Mame_03592 ENOG4108UXN response regulator Mame_03595 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Mame_03598 ENOG4105CJP fad dependent oxidoreductase Mame_03600 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_03602 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit Mame_03603 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Mame_03605 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain Mame_03606 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Mame_03607 ENOG4107XZX Involved in the transcription termination process (By similarity) Mame_03609 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Mame_03610 ENOG4105DIT ErfK YbiS YcfS YnhG family protein Mame_03612 ENOG4105D52 delta-aminolevulinic acid dehydratase Mame_03614 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate Mame_03615 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Mame_03621 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Mame_03623 ENOG4108K2B transcriptional regulator Mame_03624 ENOG4105F8D glycoside hydrolase family 4 Mame_03625 ENOG4105MVE transcriptional regulator Mame_03626 ENOG4105RD7 BadF BadG BcrA BcrD Mame_03628 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component Mame_03630 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Mame_03631 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of Mame_03633 ENOG4105C2J ABC transporter Mame_03634 ENOG41062B0 ABC transporter, permease Mame_03636 ENOG4105C9M aspartyl-trna synthetase Mame_03637 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) Mame_03641 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) Mame_03642 ENOG4105C9X ppx gppa phosphatase Mame_03647 ENOG4105CDY transcriptional regulatory protein Mame_03649 ENOG4105DEN Luciferase family Mame_03650 ENOG4105JQN Transcriptional regulator Mame_03651 ENOG4107S5I aldo keto reductase Mame_03652 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Mame_03653 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Mame_03654 ENOG4105ZEG Suppressor protein Mame_03656 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Mame_03658 ENOG4105C02 permease Mame_03659 ENOG4105CXB phosphoribosylaminoimidazole synthetase Mame_03660 ENOG4108V3E phosphoribosylglycinamide formyltransferase Mame_03662 ENOG4105C5X domain protein Mame_03663 ENOG41090HR transcriptional regulator Mame_03664 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Mame_03665 ENOG4105E0F Histidine kinase Mame_03667 ENOG4105BZU Histidine kinase Mame_03668 ENOG4108R85 Short chain dehydrogenase Mame_03669 ENOG4105CXK mandelate racemase muconate lactonizing Mame_03671 ENOG4108ZKT aldose 1-epimerase Mame_03672 ENOG4105CNN ABC, transporter Mame_03673 ENOG4108F37 ATP-binding component of a transport system Mame_03674 ENOG4105FCA ABC transporter periplasmic-binding protein YphF Mame_03675 ENOG4107YCY Transcriptional regulator Mame_03676 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 Mame_03677 ENOG4108RTU Aldolase Mame_03682 ENOG41090KR LysR family transcriptional Regulator Mame_03685 ENOG4105NAE bifunctional deaminase-reductase domain protein Mame_03697 ENOG4105CHR reductase Mame_03698 ENOG4105KVH Transcriptional regulator Mame_03700 ENOG4108HPI phosphatidate Cytidylyltransferase Mame_03706 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component Mame_03707 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Mame_03711 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Mame_03713 ENOG4105E0A ABC, transporter Mame_03714 ENOG4108IHU transport system permease protein Mame_03715 ENOG4105DQ5 transport system permease protein Mame_03717 ENOG4105E0K tonB-dependent siderophore receptor Mame_03720 ENOG4105C1G acyl-Coa dehydrogenase Mame_03721 ENOG4105CGU Enoyl-CoA hydratase Mame_03722 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Mame_03723 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Mame_03728 ENOG4105CHR reductase Mame_03730 ENOG4105CC9 acyl-Coa dehydrogenase Mame_03731 ENOG4105CD5 CoA-binding domain protein Mame_03732 ENOG4105E39 Enoyl-CoA hydratase Mame_03734 ENOG4108IG5 Transcriptional regulator Mame_03735 ENOG4105HEI LysR family (Transcriptional regulator Mame_03739 ENOG4105CNW domain protein Mame_03740 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Mame_03741 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) Mame_03746 ENOG4105CEC DNA methylase N-4 N-6 Mame_03750 ENOG4105D48 metallophosphoesterase Mame_03756 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Mame_03761 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) Mame_03762 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Mame_03765 ENOG4105CAU Arsenical resistance protein, ArsH Mame_03766 ENOG4105K89 arsenate reductase Mame_03767 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Mame_03768 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Mame_03769 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Mame_03771 ENOG4108RVA ribokinase Mame_03772 ENOG4108HWW ABC transporter Mame_03774 ENOG4105DFW ABC transporter Mame_03775 ENOG4105DFW ABC transporter Mame_03781 ENOG4105CEY Amp-dependent synthetase and ligase Mame_03782 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Mame_03787 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_03789 ENOG4108K3A Glutathione S-transferase Mame_03790 ENOG41062D9 Histidine kinase Mame_03792 ENOG4105ETX regulatoR Mame_03793 ENOG4105T0Z Conserved Protein Mame_03794 ENOG4108JJB ABC transporter Mame_03795 ENOG4107QCX Transporter Mame_03796 ENOG4107ZYJ bioY protein Mame_03798 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Mame_03799 ENOG4105EUB pirin domain protein Mame_03800 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Mame_03801 ENOG4105DX0 Hemolysin A Mame_03802 ENOG4107QS4 23S rRNA Mame_03803 ENOG4105W6J BA14K family Mame_03806 ENOG4105KVH Transcriptional regulator Mame_03807 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Mame_03808 ENOG4105CPC Aldo Keto reductase Mame_03810 ENOG4105CRQ synthase (Component I) Mame_03811 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Mame_03812 ENOG4105EIN peptidylprolyl cis-trans isomerase Mame_03813 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Mame_03814 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Mame_03815 ENOG4105M6F mutator MutT protein Mame_03816 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Mame_03817 ENOG41081UC Inherit from COG: Competence protein Mame_03818 ENOG4105VW4 glutaredoxin 3 Mame_03823 ENOG4108ZHJ Organic hydroperoxide resistance protein Mame_03824 ENOG4105K56 Transcriptional regulator Mame_03826 ENOG4105CPQ Dehydrogenase Mame_03829 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) Mame_03830 ENOG4105K2J Transcriptional regulator Mame_03832 ENOG4105CH5 extracellular solute-binding protein, family 7 Mame_03836 ENOG4105CJ1 ABC, transporter Mame_03837 ENOG4107QWP ABC-2 type transporter Mame_03841 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Mame_03842 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Mame_03843 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) Mame_03844 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Mame_03845 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 Mame_03846 ENOG4108ESZ Glycogen debranching enzyme Mame_03850 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Mame_03852 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) Mame_03853 ENOG4105DDR sarcosine oxidase (Beta subunit) Mame_03859 ENOG4106QJH hemin transport protein Mame_03860 ENOG4107R4I Periplasmic binding protein Mame_03861 ENOG4105EHG Permease protein Mame_03862 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Mame_03863 ENOG4106H78 methyltransferase Mame_03864 ENOG4105FE9 pseudouridine synthase Mame_03865 ENOG4108Z6B deaminase Mame_03866 ENOG4105KD7 acetyltransferase Mame_03868 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Mame_03869 ENOG4105DTN riboflavin biosynthesis protein ribF Mame_03872 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Mame_03873 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Mame_03877 ENOG4108Z9Z response to DNA damage stimulus Mame_03878 ENOG4105CYM Glutathione S-transferase Mame_03880 ENOG4107QNJ CoA-transferase subunit B Mame_03881 ENOG4105CHU acetyl-coa acetyltransferase Mame_03882 ENOG4107HP6 Transcriptional regulator Mame_03890 ENOG4105EJC lysr family transcriptional regulator Mame_03891 ENOG4105CQB FAD linked oxidase domain protein Mame_03892 ENOG4105EU8 FAD linked oxidase domain protein Mame_03894 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Mame_03895 ENOG4105DU0 nucleoside hydrolase Mame_03896 ENOG4108ZNX Heat shock protein Mame_03898 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Mame_03899 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Mame_03900 ENOG4108WRK Transcriptional regulator Mame_03901 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Mame_03902 ENOG4107RCQ (CBS) domain Mame_03903 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Mame_03904 ENOG4105C9A Phoh family Mame_03905 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Mame_03906 ENOG4108Z20 Acyl-transferase Mame_03907 ENOG41090R7 Ferric uptake Mame_03909 ENOG41072GX Peptidase M22 Glycoprotease Mame_03910 ENOG41083MR nifu domain-containing protein Mame_03912 ENOG4105C31 Tryptophanyl-tRNA synthetase Mame_03915 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Mame_03917 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Mame_03918 ENOG4108RWN rrna methyltransferase Mame_03919 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Mame_03921 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) Mame_03923 ENOG4105RF0 OstA family Mame_03924 ENOG4108IUZ ABC transporter Mame_03925 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Mame_03926 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea Mame_03927 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN Mame_03929 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Mame_03930 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) Mame_03931 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) Mame_03933 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Mame_03934 ENOG4105CSA Coproporphyrinogen iii oxidase Mame_03936 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Mame_03938 ENOG4105CS1 NAD(P)H quinone oxidoreductase Mame_03939 ENOG4105CEV competence damage-inducible protein Mame_03941 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) Mame_03943 ENOG4105D1H recombination factor protein RarA Mame_03944 ENOG4105C0H protease Mame_03947 ENOG4105C01 Dihydroxy-acid dehydratase Mame_03951 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Mame_03952 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) Mame_03953 ENOG4105NX3 Membrane Mame_03955 ENOG4108ZT0 50S ribosomal protein l17 Mame_03956 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Mame_03957 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Mame_03958 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Mame_03959 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Mame_03961 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Mame_03962 ENOG41084HQ 50S ribosomal protein L30 Mame_03963 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Mame_03964 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Mame_03965 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Mame_03966 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Mame_03967 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Mame_03968 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Mame_03969 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Mame_03970 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Mame_03971 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Mame_03972 ENOG41083MP 50s ribosomal protein l29 Mame_03973 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Mame_03974 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Mame_03975 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Mame_03976 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Mame_03977 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Mame_03978 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Mame_03979 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Mame_03980 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Mame_03982 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Mame_03983 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Mame_03984 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Mame_03985 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Mame_03986 ENOG4105C5H ABC transporter Mame_03989 ENOG41066DG (EAL) domain protein Mame_03991 ENOG4105E82 cytochrome subunit of dehydrogenase Mame_03992 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Mame_03993 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Mame_03994 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Mame_03995 ENOG4108VZM 50s ribosomal protein L10 Mame_03996 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Mame_03997 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Mame_04002 ENOG4105EGS Mechanosensitive ion channel Mame_04004 ENOG4105DSF transport protein Mame_04006 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Mame_04008 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Mame_04009 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Mame_04010 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Mame_04012 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Mame_04013 ENOG410600T transposase Mame_04016 ENOG4105DZ1 carboxypeptidase Mame_04018 ENOG4108ZG0 Ompa motb domain protein Mame_04019 ENOG4108ZG0 Ompa motb domain protein Mame_04020 ENOG4105BZS acriflavin resistance protein Mame_04021 ENOG410624X efflux transporter, rnd family, mfp subunit Mame_04022 ENOG4105C4R Atp-dependent dna helicase Mame_04023 ENOG4108Z7R Chaperone CsaA Mame_04024 ENOG4105II7 pyrroline-5-carboxylate reductase Mame_04028 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Mame_04030 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Mame_04033 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Mame_04034 ENOG4105BZU Histidine kinase Mame_04035 ENOG4108RWI nicotinamidase Mame_04038 ENOG4105DC7 peptidase M24 Mame_04040 ENOG4105CSU acyl-Coa dehydrogenase Mame_04041 ENOG4105CXT aspartate transcarbamylase Mame_04042 ENOG4105CD3 dihydroorotase Mame_04043 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Mame_04047 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Mame_04048 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Mame_04049 ENOG4105BZU Histidine kinase Mame_04050 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Mame_04051 ENOG4105M74 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Mame_04052 ENOG4105C3G gtp-binding protein Mame_04053 ENOG4108V06 Glutathione peroxidase Mame_04054 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Mame_04055 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Mame_04057 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Mame_04058 ENOG4105BZ1 (ABC) transporter Mame_04059 ENOG4105BZ1 (ABC) transporter Mame_04060 ENOG4105ME7 Membrane Mame_04063 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Mame_04065 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) Mame_04068 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Mame_04071 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Mame_04076 ENOG4105CHF Glutathione S-transferase Mame_04080 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Mame_04082 ENOG4105DKK Benzoate Mame_04083 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Mame_04085 ENOG4105CHV Transcription elongation factor NusA Mame_04086 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) Mame_04087 ENOG4107SFI Major Facilitator superfamily Mame_04088 ENOG4105CVE Lytic murein transglycosylase Mame_04090 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Mame_04092 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Mame_04097 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Mame_04098 ENOG4107SN7 NLP P60 protein Mame_04099 ENOG4107SVN transposase Mame_04102 ENOG410829K Lysine exporter protein (Lyse ygga) Mame_04104 ENOG4105CVG Homoserine O-transsuccinylase Mame_04105 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) Mame_04108 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) Mame_04110 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Mame_04119 ENOG4108W6C Dehydrogenase Mame_04121 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA Mame_04122 ENOG4105C0B DNA polymerase III (alpha subunit) Mame_04125 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Mame_04126 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Mame_04127 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Mame_04129 ENOG4105KCV RNA signal recognition particle 4.5S RNA Mame_04132 ENOG4107XBN GntR Family Transcriptional Regulator Mame_04133 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit Mame_04134 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_04135 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_04136 ENOG4105BZU Histidine kinase Mame_04137 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Mame_04138 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_04140 ENOG4105CVE Lytic murein transglycosylase Mame_04142 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Mame_04144 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase Mame_04146 ENOG4105C11 sulfate adenylyltransferase), subunit 2 Mame_04149 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_04151 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Mame_04152 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Mame_04153 ENOG4105CNN ABC, transporter Mame_04154 ENOG4105C2J ABC transporter Mame_04155 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Mame_04156 ENOG4105CMG Carbohydrate kinase Mame_04157 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Mame_04163 ENOG4105ETT transcriptional Regulator, LysR family Mame_04167 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Mame_04168 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_04172 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Mame_04174 ENOG4108IFG nitrite reductase, (NAD(P)H) Mame_04178 ENOG4105I5W Transporter Mame_04180 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Mame_04183 ENOG4105VIG Sec-independent protein translocase protein TatC Mame_04184 ENOG4108RIR Molybdenum cofactor biosynthesis protein Mame_04185 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Mame_04188 ENOG41076YT nitrate reductase, gamma subunit Mame_04189 ENOG4105R3A Nitrate reductase Mame_04190 ENOG4108IUE nitrate reductase beta subunit Mame_04191 ENOG4105CRU nitrate reductase, alpha subunit Mame_04192 ENOG4105DQQ Major facilitator superfamily MFS_1 Mame_04194 ENOG4106KR7 LysR family Transcriptional regulator Mame_04197 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Mame_04198 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) Mame_04199 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Mame_04201 ENOG4108Z4U Ferredoxin Mame_04202 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Mame_04205 ENOG4107QZW Altronate oxidoreductase Mame_04206 ENOG4105CTX dehydratase Mame_04207 ENOG4105CPQ Dehydrogenase Mame_04210 ENOG4105CNN ABC, transporter Mame_04211 ENOG410617M Transcriptional regulator Mame_04212 ENOG4105CBG Sulfatase Mame_04214 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Mame_04215 ENOG4108HW4 amino acid AbC transporter Mame_04216 ENOG4107R0W ABC transporter Mame_04218 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Mame_04219 ENOG4105VDT -acetyltransferase Mame_04220 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Mame_04221 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Mame_04222 ENOG4105K5M 30s ribosomal protein S16 Mame_04223 ENOG4105EHE chorismate mutase- prephenate dehydrogenase Mame_04229 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Mame_04232 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Mame_04233 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Mame_04234 ENOG4107835 probably involved in intracellular septation (By similarity) Mame_04237 ENOG41060IM Heme exporter protein Mame_04238 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) Mame_04239 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) Mame_04240 ENOG4107QM5 aconitate hydratase Mame_04249 ENOG4107QRT dEAD DEAH box helicase Mame_04255 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Mame_04265 ENOG4105BZU Histidine kinase Mame_04266 ENOG4105CHM Aminotransferase Mame_04268 ENOG4105F0Z galactose-1-phosphate uridylyltransferase Mame_04269 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Mame_04271 ENOG4105DIK (ABC) transporter Mame_04272 ENOG4105CC5 ABC transporter Mame_04273 ENOG4105CC5 ABC transporter Mame_04274 ENOG4105EKE dihydroorotase Mame_04275 ENOG4105EXC Acyl-transferase Mame_04276 ENOG4105E7W lamb ycsf family protein Mame_04277 ENOG4105DXI Major Facilitator superfamily Mame_04279 ENOG4105CRK lysyL-tRNA synthetase Mame_04280 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Mame_04281 ENOG4105EE5 Membrane protein terC Mame_04285 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Mame_04286 ENOG4105DBV ornithine carbamoyltransferase Mame_04287 ENOG4105C8Y Acetylornithine aminotransferase Mame_04290 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Mame_04291 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family Mame_04292 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Mame_04293 ENOG4107QNK )-transporter Mame_04295 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component Mame_04296 ENOG4107Z6I Thiamine biosynthesis protein Mame_04298 ENOG4105M0T TPR Repeat-Containing Protein Mame_04299 ENOG4105YK5 50S ribosomal protein L36 Mame_04300 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit Mame_04301 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Mame_04306 ENOG4107YNJ LysR family Transcriptional regulator Mame_04307 ENOG4105K6H D-cysteine desulfhydrase Mame_04310 ENOG4106FTQ Taurine ABC transporter, periplasmic Mame_04311 ENOG4108IY8 ABC, transporter Mame_04312 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Mame_04313 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Mame_04314 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) Mame_04317 ENOG4107QZV Type I secretion membrane fusion protein Mame_04318 ENOG4105BZ1 (ABC) transporter Mame_04320 ENOG4105ERG peptidase m48, ste24p Mame_04325 ENOG4105GR3 Histidine kinase Mame_04331 ENOG4105CPQ Dehydrogenase Mame_04334 ENOG4105EE1 crotonyl-CoA reductase Mame_04336 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Mame_04337 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) Mame_04338 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) Mame_04339 ENOG4105KAV tspo and mbr like protein Mame_04345 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) Mame_04346 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Mame_04347 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Mame_04348 ENOG4105C7K acetolactate synthase Mame_04349 ENOG4105C5I Dehydrogenase Mame_04350 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) Mame_04358 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Mame_04362 ENOG4105C32 Amino acid ABC transporter (Permease) Mame_04363 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Mame_04364 ENOG4105C0Z ABC transporter Mame_04365 ENOG4108IV0 ABC, transporter Mame_04367 ENOG4105E1J oxidoreductase Mame_04368 ENOG4107QKG PfaD family Mame_04373 ENOG4105ERH Fumarylacetoacetate hydrolase Mame_04374 ENOG4106517 Short-chain dehydrogenase reductase Sdr Mame_04376 ENOG4105CTX dehydratase Mame_04377 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) Mame_04379 ENOG4105C2J ABC transporter Mame_04381 ENOG4105CNN ABC, transporter Mame_04382 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator Mame_04384 ENOG4105C0W non-ribosomal peptide synthetase Mame_04385 ENOG4105C0W non-ribosomal peptide synthetase Mame_04386 ENOG4105C0W non-ribosomal peptide synthetase Mame_04387 ENOG4107RCI amp-dependent synthetase and ligase Mame_04391 ENOG4105DHU Bile acid Mame_04392 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_04394 ENOG4108JQ7 (ABC) transporter Mame_04397 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Mame_04398 ENOG4105G3Z GntR family transcriptional regulator Mame_04401 ENOG4105CJ3 phosphate transporter Mame_04405 ENOG4105CHR reductase Mame_04407 ENOG4105ETE Transcriptional regulator (LacI family Mame_04408 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of Mame_04409 ENOG4107UEK pfkb domain protein Mame_04410 ENOG4105CNN ABC, transporter Mame_04411 ENOG4105C2J ABC transporter Mame_04414 ENOG4105F38 ABC transporter, permease Mame_04415 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component Mame_04419 ENOG4105CPN adenine deaminase Mame_04423 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr Mame_04426 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Mame_04432 ENOG4107SFQ iron-sulfur binding Mame_04444 ENOG4105BZU Histidine kinase Mame_04447 ENOG4108Z9Z response to DNA damage stimulus Mame_04450 ENOG4107E6A Cytochrome p-450 Mame_04467 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Mame_04473 ENOG4108IG5 Transcriptional regulator Mame_04474 ENOG4105BZU Histidine kinase Mame_04476 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Mame_04480 ENOG4107R16 Multicopper oxidase Mame_04486 ENOG4105CMM transposase Mame_04488 ENOG4105CE4 GlcNAc 6-P deacetylase Mame_04490 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Mame_04491 ENOG4105DRS transport system, permease Mame_04493 ENOG4105FDP GntR family transcriptional regulator Mame_04494 ENOG4108SU4 UPF0309 protein Mame_04495 ENOG4108IJ9 (ABC) transporter Mame_04496 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) Mame_04499 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component Mame_04501 ENOG4105DRR Transcriptional regulator, GntR family Mame_04504 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) Mame_04505 ENOG4107TYC hydantoinase B oxoprolinase Mame_04506 ENOG4105HKX acetone carboxylase, gamma subunit Mame_04509 ENOG4105DEF Extracellular solute-binding protein, family 5 Mame_04511 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_04513 ENOG4105DC7 peptidase M24 Mame_04516 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Mame_04520 ENOG4105DRS transport system, permease Mame_04521 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_04524 ENOG4107SVH Potassium channel protein Mame_04530 ENOG4108JJ6 Type I secretion system ATPase Mame_04537 ENOG4105E2V Glycosyltransferase 36 Mame_04541 ENOG4105C1P efflux transporter, rnd family, mfp subunit Mame_04542 ENOG4105BZS acriflavin resistance protein Mame_04543 ENOG4105E3W Two component transcriptional regulator (Winged helix family Mame_04544 ENOG4105BZU Histidine kinase Mame_04546 ENOG4105CGU Enoyl-CoA hydratase Mame_04549 ENOG4105EXG Transcriptional regulator Mame_04557 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Mame_04561 ENOG4105GAK amidohydrolase 2 Mame_04564 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_04566 ENOG4105RD8 TRAP dicarboxylate transporter Mame_04569 ENOG4105ES4 Nitrilase Mame_04570 ENOG4105ES4 Nitrilase Mame_04572 ENOG41062JF Transcriptional regulator Mame_04578 ENOG4105CZE histidine utilization repressor Mame_04579 ENOG4105C84 Histidine ammonia-lyase Mame_04580 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system Mame_04583 ENOG4105E90 ABC transporter Mame_04584 ENOG4105E90 ABC transporter Mame_04585 ENOG4108IJ8 ABC transporter Mame_04590 ENOG4105NAE bifunctional deaminase-reductase domain protein Mame_04594 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Mame_04595 ENOG4107HP6 Transcriptional regulator Mame_04597 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Mame_04601 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_04602 ENOG4105CD5 CoA-binding domain protein Mame_04607 ENOG4107EFR Flavocytochrome c Mame_04613 ENOG4105C32 Amino acid ABC transporter (Permease) Mame_04614 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Mame_04615 ENOG4105C0Z ABC transporter Mame_04616 ENOG4108IV0 ABC, transporter Mame_04618 ENOG4107258 Transcriptional regulator Mame_04620 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase Mame_04621 ENOG4105MP9 class II Aldolase Mame_04622 ENOG4105CHM Aminotransferase Mame_04623 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) Mame_04627 ENOG4105CSU acyl-Coa dehydrogenase Mame_04629 ENOG4105CHU acetyl-coa acetyltransferase Mame_04630 ENOG4108Z6Z Transcriptional regulator Mame_04631 ENOG4105CEY Amp-dependent synthetase and ligase Mame_04632 ENOG4108TGP Thioesterase superfamily protein Mame_04634 ENOG4105TPV Mame_04636 ENOG4105CHR reductase Mame_04640 ENOG4108K2P TRANSCRIPTIONal Mame_04641 ENOG4105C7K acetolactate synthase Mame_04647 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_04648 ENOG4108YXU transcriptional regulator AsnC family Mame_04649 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Mame_04650 ENOG4107QSN dihydrolipoamide acetyltransferase Mame_04651 ENOG4107QN2 dihydrolipoyl dehydrogenase Mame_04653 ENOG4105ERH Fumarylacetoacetate hydrolase Mame_04658 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) Mame_04660 ENOG4108K2P TRANSCRIPTIONal Mame_04662 ENOG4105DRR Transcriptional regulator, GntR family Mame_04663 ENOG4105RD8 TRAP dicarboxylate transporter Mame_04665 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_04670 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_04674 ENOG4105C5I Dehydrogenase Mame_04675 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) Mame_04684 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Mame_04685 ENOG4108IJ9 (ABC) transporter Mame_04686 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Mame_04688 ENOG4105CNG UPF0061 protein Mame_04690 ENOG4105CQZ Histidine kinase Mame_04691 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Mame_04692 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Mame_04693 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ Mame_04694 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_04696 ENOG4108J5G 6-phosphogluconate dehydrogenase Mame_04701 ENOG4105DFH Transport of potassium into the cell (By similarity) Mame_04703 ENOG4105C9F isomerase Mame_04705 ENOG410804X Transcriptional regulator Mame_04707 ENOG4105C2J ABC transporter Mame_04708 ENOG4105CNN ABC, transporter Mame_04709 ENOG4105F5R ABC transporter Mame_04712 ENOG4105DRR Transcriptional regulator, GntR family Mame_04713 ENOG4105CXK mandelate racemase muconate lactonizing Mame_04716 ENOG4105DRS transport system, permease Mame_04719 ENOG4108KEZ Dehydrogenase Mame_04720 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Mame_04721 ENOG4105E39 Enoyl-CoA hydratase Mame_04722 ENOG4105CNN ABC, transporter Mame_04724 ENOG4105C2J ABC transporter Mame_04726 ENOG4105ETE Transcriptional regulator (LacI family Mame_04731 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA Mame_04732 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) Mame_04738 ENOG4108IJ9 (ABC) transporter Mame_04739 ENOG4105DIA mandelate racemase muconate lactonizing Mame_04740 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr Mame_04741 ENOG4105DIA mandelate racemase muconate lactonizing Mame_04744 ENOG4106J7G oxidoreductase Mame_04747 ENOG4108NQD Mame_04749 ENOG4105CNN ABC, transporter Mame_04750 ENOG4105C2J ABC transporter Mame_04752 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Mame_04753 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate Mame_04756 ENOG4105ECR NmrA family Mame_04759 ENOG4105E98 transcriptional regulator DeoR family Mame_04760 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_04764 ENOG4105MWK D-amino acid dehydrogenase, small subunit Mame_04768 ENOG4105ETE Transcriptional regulator (LacI family Mame_04770 ENOG4105CV8 reductase Mame_04771 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Mame_04774 ENOG4108JP0 extracellular solute-binding protein family 1 Mame_04778 ENOG4105JSC dimethylmenaquinone methyltransferase Mame_04781 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Mame_04782 ENOG4105D56 permease protein Mame_04783 ENOG4105BZ7 extracellular solute-binding protein family 1 Mame_04784 ENOG4105CXK mandelate racemase muconate lactonizing Mame_04785 ENOG4107258 Transcriptional regulator Mame_04786 ENOG4105CXK mandelate racemase muconate lactonizing Mame_04788 ENOG4105CKK Glycosyl transferase, family 2 Mame_04790 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Mame_04791 ENOG4105E0F Histidine kinase Mame_04795 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Mame_04798 ENOG4105ECR NmrA family Mame_04799 ENOG4105KVH Transcriptional regulator Mame_04801 ENOG4105DUM transcriptional regulator, lysR family Mame_04807 ENOG4105VDM plasmid maintenance system antidote protein, xre family Mame_04809 ENOG4105EQ2 LysR family Transcriptional regulator Mame_04810 ENOG4105CHR reductase Mame_04811 ENOG4105KVH Transcriptional regulator Mame_04816 ENOG4107TFG D-allose kinase Mame_04819 ENOG4107UWC ABC, transporter Mame_04820 ENOG4105CBG Sulfatase Mame_04821 ENOG4105CHR reductase Mame_04822 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_04823 ENOG4105CBG Sulfatase Mame_04825 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Mame_04835 ENOG4105E5Q amino acid AbC transporter Mame_04836 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Mame_04837 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Mame_04838 ENOG4105C26 Dehydrogenase Mame_04841 ENOG4107VFR oxidoreductase Mame_04842 ENOG4105CR8 Transcriptional regulator Mame_04847 ENOG4105E7U AraC family transcriptional regulator Mame_04848 ENOG4107GJV short-chain dehydrogenase reductase Mame_04851 ENOG41062ES Transcriptional regulator Mame_04853 ENOG4108UQ8 endoribonuclease L-psp Mame_04856 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Mame_04857 ENOG4105CNN ABC, transporter Mame_04858 ENOG4105C2J ABC transporter Mame_04860 ENOG4105DG4 malate L-lactate dehydrogenase Mame_04867 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Mame_04868 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_04870 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) Mame_04871 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Mame_04872 ENOG4107SVN transposase Mame_04875 ENOG4105CNU cell division protein FtsK Mame_04876 ENOG4108NEV two component transcriptional regulator, LytTR family Mame_04888 ENOG4105PGM cation diffusion facilitator family transporter Mame_04890 ENOG4105W5Q DNA repair protein (RadC Mame_04896 ENOG4105EQR Transposase IS116 IS110 IS902 Mame_04908 ENOG4105C0D helicase Mame_04910 ENOG4108I5C dEAD DEAH box helicase Mame_04925 ENOG4105CMA conjugation trbi family protein Mame_04929 ENOG4105E4C Lytic transglycosylase catalytic Mame_04934 ENOG4105E4C Lytic transglycosylase catalytic Mame_04940 ENOG4105F5W AtP-binding protein Mame_04943 ENOG4105XUP Phage derived protein Gp49-like (DUF891) Mame_04947 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein Mame_04952 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A Mame_04983 ENOG4105KK4 UPF0060 membrane protein Mame_04985 ENOG4105CZX twitching motility protein Mame_04993 ENOG4105YES addiction module antidote protein Mame_04994 ENOG4105VUH addiction module killer protein Mame_04996 ENOG4105MZU cell filamentation protein Mame_05001 ENOG4105CAU Arsenical resistance protein, ArsH Mame_05002 ENOG4107R5R arsenical pump membrane protein Mame_05004 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Mame_05005 ENOG4108UTW Plays a role in the regulation of phosphate uptake Mame_05009 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Mame_05015 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Mame_05017 ENOG4105E3B Multicopper oxidase Mame_05018 ENOG4107TJ9 Cytochrome Mame_05026 ENOG4105PGM cation diffusion facilitator family transporter Mame_05029 ENOG4106FI7 cytochrome c-type biogenesis protein Mame_05030 ENOG4105KWW Biogenesis protein Mame_05031 ENOG4107QX9 Thiol disulfide interChange protein Mame_05032 ENOG4105DA4 cytochrome c-type biogenesis protein Mame_05035 ENOG4105E0F Histidine kinase Mame_05036 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Mame_05041 ENOG4108RSN SNARE associated Golgi Mame_05042 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Mame_05043 ENOG4107VUZ Mame_05044 ENOG4105CY0 Metallo-Beta-Lactamase Mame_05045 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) Mame_05046 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Mame_05051 ENOG4105D70 Integrase catalytic subunit Mame_05057 ENOG4105H3G oxidoreductase Mame_05059 ENOG4107QIV Cytochrome c biogenesis protein Mame_05060 ENOG4108ZX6 Electron transport protein SCO1 SenC Mame_05061 ENOG4105PGM cation diffusion facilitator family transporter Mame_05065 ENOG4108KQ5 Integrase catalytic subunit Mame_05069 ENOG4105CMI transporter Mame_05070 ENOG4105CJ1 ABC, transporter Mame_05071 ENOG4105D0S secretion protein (HlyD Mame_05074 ENOG4107R37 Glutamate dehydrogenase Mame_05075 ENOG4105D5G Transposase Mame_05086 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_05088 ENOG4108UAU isochorismatase Mame_05093 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase Mame_05098 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Mame_05100 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Mame_05102 ENOG4108NDG TRAP dicarboxylate Mame_05114 ENOG4105VT3 DNA binding domain protein, excisionase family Mame_05128 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Mame_05136 ENOG410600T transposase Mame_05137 ENOG4105CX8 fg-gap repeat protein Mame_05138 ENOG4108JJ6 Type I secretion system ATPase Mame_05140 ENOG4107VG4 Xylose isomerase domain protein TIM barrel Mame_05144 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component Mame_05145 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Mame_05146 ENOG4105CPQ Dehydrogenase Mame_05148 ENOG4105CXG d-lactate dehydrogenase Mame_05151 ENOG4105CXK mandelate racemase muconate lactonizing Mame_05152 ENOG4105CXK mandelate racemase muconate lactonizing Mame_05153 ENOG4108JQ6 ABC transporter Mame_05154 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Mame_05157 ENOG4105EMF GntR family transcriptional regulator Mame_05162 ENOG4105EAD ABC transporter Mame_05163 ENOG4105DRP amino acid AbC transporter Mame_05164 ENOG4105CDA abc transporter atp-binding protein Mame_05166 ENOG4105CHM Aminotransferase Mame_05169 ENOG4105CHR reductase Mame_05172 ENOG4108R85 Short chain dehydrogenase Mame_05173 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Mame_05174 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Mame_05178 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component Mame_05180 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_05183 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Mame_05185 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Mame_05188 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Mame_05190 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Mame_05194 ENOG4105CBG Sulfatase Mame_05200 ENOG4105DMT epimerase dehydratase Mame_05202 ENOG410642W LysR family Transcriptional regulator Mame_05205 ENOG410642W LysR family Transcriptional regulator Mame_05207 ENOG410642W LysR family Transcriptional regulator Mame_05208 ENOG4105CY0 Metallo-Beta-Lactamase Mame_05209 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta Mame_05212 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Mame_05215 ENOG4105DNH Major Facilitator Mame_05216 ENOG4105CF7 AraC family transcriptional regulator Mame_05221 ENOG4105KVH Transcriptional regulator Mame_05225 ENOG4105ETE Transcriptional regulator (LacI family Mame_05226 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Mame_05227 ENOG4108SU4 UPF0309 protein Mame_05232 ENOG4105DRS transport system, permease Mame_05236 ENOG4105CMM transposase Mame_05241 ENOG4105DTQ mandelate racemase muconate lactonizing Mame_05249 ENOG4105JN3 extra-cytoplasmic solute receptor family protein Mame_05255 ENOG4108JQ1 Dehydrogenase Mame_05260 ENOG4105ETE Transcriptional regulator (LacI family Mame_05265 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Mame_05269 ENOG4108IJ9 (ABC) transporter Mame_05270 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Mame_05271 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component Mame_05273 ENOG4107KJX Transcriptional regulator