locus-tag	class	description
Mame_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Mame_00002	COG1393	Belongs to the ArsC family
Mame_00003	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Mame_00006	COG2309	aminopeptidase activity
Mame_00007	COG1570	exodeoxyribonuclease VII activity
Mame_00012	COG0667	Aldo Keto reductase
Mame_00014	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Mame_00015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Mame_00016	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Mame_00021	COG0747	negative chemotaxis
Mame_00022	COG0601	transmembrane transport
Mame_00023	COG0444	Belongs to the ABC transporter superfamily
Mame_00024	COG4608	Belongs to the ABC transporter superfamily
Mame_00027	COG1363	Peptidase, m42
Mame_00028	COG1181	Belongs to the D-alanine--D-alanine ligase family
Mame_00029	COG0367	asparagine synthase
Mame_00036	COG2072	flavoprotein involved in K transport
Mame_00037	COG0583	DNA-binding transcription factor activity
Mame_00038	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_00040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mame_00043	COG0251	oxidation-reduction process
Mame_00044	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Mame_00046	COG0583	DNA-binding transcription factor activity
Mame_00051	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Mame_00051	COG3743	rRNA binding
Mame_00054	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Mame_00060	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Mame_00061	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Mame_00062	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Mame_00064	COG5425	PFAM Usg family protein
Mame_00065	COG0656	L-ascorbic acid biosynthetic process
Mame_00071	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Mame_00072	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Mame_00073	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Mame_00074	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Mame_00076	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Mame_00077	COG0006	proline dipeptidase activity
Mame_00080	COG0523	cobalamin synthesis protein
Mame_00081	COG4948	Mandelate Racemase Muconate Lactonizing
Mame_00083	COG0662	Cupin 2, conserved barrel domain protein
Mame_00083	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Mame_00084	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Mame_00088	COG0598	Magnesium transport protein CorA
Mame_00090	COG0356	it plays a direct role in the translocation of protons across the membrane
Mame_00091	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Mame_00092	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Mame_00093	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Mame_00094	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Mame_00097	COG1984	allophanate hydrolase subunit 2
Mame_00098	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Mame_00099	COG1840	ABC-type Fe3 transport system, periplasmic component
Mame_00100	COG3842	ATPase activity
Mame_00105	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Mame_00108	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Mame_00109	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_00110	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Mame_00111	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mame_00120	COG1802	Transcriptional regulator
Mame_00121	COG2945	thiolester hydrolase activity
Mame_00121	COG0596	Alpha beta hydrolase
Mame_00125	COG0235	Class ii aldolase
Mame_00129	COG1250	3-hydroxyacyl-CoA dehydrogenase
Mame_00132	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_00133	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Mame_00134	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Mame_00134	COG1116	anion transmembrane transporter activity
Mame_00135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Mame_00137	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mame_00138	COG4569	acetaldehyde dehydrogenase (acetylating) activity
Mame_00139	COG0410	ABC transporter
Mame_00143	COG0683	leucine binding
Mame_00146	COG1414	Transcriptional regulator
Mame_00149	COG1121	(ABC) transporter
Mame_00151	COG3443	Belongs to the bacterial solute-binding protein 9 family
Mame_00152	COG0523	cobalamin synthesis protein
Mame_00156	COG1999	signal sequence binding
Mame_00157	COG1126	abc transporter atp-binding protein
Mame_00158	COG0765	amino acid transport
Mame_00159	COG4597	amino acid ABC transporter
Mame_00160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Mame_00161	COG0626	cystathionine gamma-synthase activity
Mame_00163	COG0583	DNA-binding transcription factor activity
Mame_00165	COG1609	Transcriptional regulator
Mame_00166	COG1177	transmembrane transport
Mame_00167	COG3842	ATPase activity
Mame_00168	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Mame_00169	COG1176	ABC-type spermidine putrescine transport system, permease component I
Mame_00171	COG0024	Methionine aminopeptidase
Mame_00173	COG1175	transmembrane transport
Mame_00180	COG1024	Enoyl-CoA hydratase
Mame_00182	COG0318	PFAM AMP-dependent synthetase and ligase
Mame_00183	COG1024	Enoyl-CoA hydratase
Mame_00186	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mame_00189	COG1175	transmembrane transport
Mame_00190	COG1840	ABC-type Fe3 transport system, periplasmic component
Mame_00192	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Mame_00193	COG0583	DNA-binding transcription factor activity
Mame_00195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Mame_00196	COG2197	response regulator
Mame_00204	COG4638	Rieske (2fe-2S)
Mame_00205	COG1174	glycine betaine transport
Mame_00209	COG0583	DNA-binding transcription factor activity
Mame_00211	COG3119	arylsulfatase activity
Mame_00212	COG3119	arylsulfatase activity
Mame_00215	COG0601	transmembrane transport
Mame_00216	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mame_00227	COG0446	pyridine nucleotide-disulphide oxidoreductase
Mame_00230	COG0516	GMP reductase activity
Mame_00230	COG0517	IMP dehydrogenase activity
Mame_00231	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Mame_00232	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Mame_00233	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Mame_00238	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Mame_00239	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Mame_00242	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Mame_00243	COG2235	arginine
Mame_00244	COG1288	antiporter activity
Mame_00245	COG0693	protein deglycase activity
Mame_00247	COG1091	dTDP-4-dehydrorhamnose reductase activity
Mame_00248	COG1088	dTDP-glucose 4,6-dehydratase activity
Mame_00249	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Mame_00250	COG1442	glycosyl transferase family 8
Mame_00252	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Mame_00254	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Mame_00256	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Mame_00256	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Mame_00257	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_00258	COG1129	ABC transporter
Mame_00261	COG2084	Dehydrogenase
Mame_00264	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Mame_00267	COG2115	Belongs to the xylose isomerase family
Mame_00268	COG1070	Carbohydrate kinase
Mame_00269	COG1609	Transcriptional regulator
Mame_00272	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Mame_00273	COG1349	DNA-binding transcription factor activity
Mame_00275	COG0402	S-adenosylhomocysteine deaminase activity
Mame_00281	COG0747	negative chemotaxis
Mame_00284	COG0444	Belongs to the ABC transporter superfamily
Mame_00286	COG3836	Belongs to the HpcH HpaI aldolase family
Mame_00287	COG0640	Transcriptional regulator
Mame_00290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Mame_00292	COG0765	amino acid transport
Mame_00297	COG3833	ABC-type maltose transport systems, permease component
Mame_00298	COG3842	ATPase activity
Mame_00299	COG0584	glycerophosphoryl diester phosphodiesterase
Mame_00300	COG1609	Transcriptional regulator
Mame_00302	COG3842	ATPase activity
Mame_00304	COG1175	transmembrane transport
Mame_00306	COG1940	carbohydrate kinase activity
Mame_00309	COG0667	Aldo Keto reductase
Mame_00313	COG0395	ABC-type sugar transport system, permease component
Mame_00315	COG3842	ATPase activity
Mame_00318	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_00319	COG1129	ABC transporter
Mame_00323	COG2186	Transcriptional regulator
Mame_00324	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Mame_00325	COG3938	Belongs to the proline racemase family
Mame_00326	COG0747	negative chemotaxis
Mame_00328	COG0601	transmembrane transport
Mame_00330	COG0444	Belongs to the ABC transporter superfamily
Mame_00334	COG1653	transport
Mame_00335	COG1175	transmembrane transport
Mame_00338	COG3842	ATPase activity
Mame_00343	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Mame_00345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mame_00346	COG1802	Transcriptional regulator
Mame_00357	COG3485	protocatechuate 3,4-dioxygenase
Mame_00360	COG0410	ABC transporter
Mame_00361	COG1137	ATPase activity
Mame_00364	COG0596	Alpha beta hydrolase
Mame_00366	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_00369	COG1137	ATPase activity
Mame_00371	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_00373	COG4166	transmembrane transport
Mame_00374	COG0601	transmembrane transport
Mame_00375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mame_00382	COG0714	Associated with various cellular activities
Mame_00385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Mame_00391	COG0583	DNA-binding transcription factor activity
Mame_00395	COG1175	transmembrane transport
Mame_00398	COG0583	DNA-binding transcription factor activity
Mame_00400	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_00401	COG1129	ABC transporter
Mame_00402	COG1879	ABC-type sugar transport system periplasmic component
Mame_00404	COG1090	epimerase
Mame_00405	COG1129	ABC transporter
Mame_00406	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_00407	COG1609	Transcriptional regulator
Mame_00410	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mame_00411	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_00412	COG3257	ureidoglycine aminohydrolase activity
Mame_00418	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Mame_00419	COG1960	acyl-CoA dehydrogenase activity
Mame_00420	COG1960	acyl-CoA dehydrogenase activity
Mame_00423	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Mame_00424	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Mame_00426	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Mame_00427	COG1024	Enoyl-CoA hydratase
Mame_00430	COG1250	3-hydroxyacyl-CoA dehydrogenase
Mame_00430	COG1024	Enoyl-CoA hydratase
Mame_00431	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Mame_00437	COG1917	Cupin 2, conserved barrel domain protein
Mame_00437	COG4977	sequence-specific DNA binding
Mame_00438	COG1486	melibiose metabolic process
Mame_00439	COG0747	negative chemotaxis
Mame_00440	COG0601	transmembrane transport
Mame_00441	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mame_00442	COG4172	Belongs to the ABC transporter superfamily
Mame_00443	COG1486	melibiose metabolic process
Mame_00456	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Mame_00457	COG3958	Transketolase
Mame_00458	COG3959	Transketolase, thiamine diphosphate binding domain
Mame_00459	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_00461	COG1129	ABC transporter
Mame_00462	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_00463	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_00465	COG0601	transmembrane transport
Mame_00467	COG4172	Belongs to the ABC transporter superfamily
Mame_00471	COG0747	negative chemotaxis
Mame_00472	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Mame_00472	COG0446	pyridine nucleotide-disulphide oxidoreductase
Mame_00475	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_00476	COG1129	ABC transporter
Mame_00477	COG2188	Transcriptional regulator
Mame_00478	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mame_00479	COG3395	kinase activity
Mame_00480	COG0235	Class ii aldolase
Mame_00481	COG3622	Belongs to the hyi family
Mame_00484	COG2198	Histidine kinase
Mame_00484	COG5002	protein histidine kinase activity
Mame_00484	COG0784	Response regulator, receiver
Mame_00492	COG3436	PFAM IS66 Orf2 family protein
Mame_00494	COG1024	Enoyl-CoA hydratase
Mame_00497	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Mame_00502	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Mame_00507	COG1960	acyl-CoA dehydrogenase activity
Mame_00509	COG1250	3-hydroxyacyl-CoA dehydrogenase
Mame_00509	COG1024	Enoyl-CoA hydratase
Mame_00510	COG1024	Enoyl-CoA hydratase
Mame_00516	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_00517	COG1960	acyl-CoA dehydrogenase activity
Mame_00518	COG1960	acyl-CoA dehydrogenase activity
Mame_00519	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_00520	COG1960	acyl-CoA dehydrogenase activity
Mame_00521	COG1960	acyl-CoA dehydrogenase activity
Mame_00522	COG1024	Enoyl-CoA hydratase
Mame_00523	COG0318	PFAM AMP-dependent synthetase and ligase
Mame_00524	COG1414	Transcriptional regulator
Mame_00525	COG2030	dehydratase
Mame_00527	COG1024	Enoyl-CoA hydratase
Mame_00530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mame_00531	COG2301	Belongs to the HpcH HpaI aldolase family
Mame_00532	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
Mame_00533	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Mame_00537	COG1802	Transcriptional regulator
Mame_00540	COG0411	ABC transporter
Mame_00542	COG0559	Belongs to the binding-protein-dependent transport system permease family
Mame_00544	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_00546	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Mame_00548	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mame_00550	COG0747	negative chemotaxis
Mame_00553	COG4172	Belongs to the ABC transporter superfamily
Mame_00554	COG4948	Mandelate Racemase Muconate Lactonizing
Mame_00555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mame_00557	COG2186	Transcriptional regulator
Mame_00558	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Mame_00559	COG2084	Dehydrogenase
Mame_00562	COG0281	malic enzyme
Mame_00562	COG0280	phosphate acetyltransferase
Mame_00563	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Mame_00565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mame_00567	COG0747	negative chemotaxis
Mame_00569	COG1522	sequence-specific DNA binding
Mame_00570	COG1104	cysteine desulfurase activity
Mame_00571	COG2072	flavoprotein involved in K transport
Mame_00574	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Mame_00587	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mame_00589	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Mame_00590	COG1280	lysine exporter protein (LysE YggA)
Mame_00591	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Mame_00592	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Mame_00596	COG0802	atpase or kinase
Mame_00597	COG2205	protein histidine kinase activity
Mame_00599	COG0251	oxidation-reduction process
Mame_00602	COG3142	Participates in the control of copper homeostasis
Mame_00606	COG0837	glucose binding
Mame_00606	COG1737	Transcriptional regulator
Mame_00609	COG0443	Heat shock 70 kDa protein
Mame_00613	COG0302	gtp cyclohydrolase
Mame_00625	COG1136	(ABC) transporter
Mame_00626	COG1396	sequence-specific DNA binding
Mame_00628	COG1414	Transcriptional regulator
Mame_00630	COG0179	Fumarylacetoacetate (FAA) hydrolase
Mame_00631	COG1063	alcohol dehydrogenase
Mame_00633	COG0318	PFAM AMP-dependent synthetase and ligase
Mame_00634	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_00635	COG4608	Belongs to the ABC transporter superfamily
Mame_00636	COG0444	Belongs to the ABC transporter superfamily
Mame_00637	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mame_00638	COG0601	transmembrane transport
Mame_00639	COG0747	negative chemotaxis
Mame_00641	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Mame_00642	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Mame_00647	COG0471	metal ion transport
Mame_00647	COG3273	potassium ion transport
Mame_00651	COG1780	Probably involved in ribonucleotide reductase function
Mame_00654	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Mame_00655	COG1845	cytochrome c oxidase, subunit III
Mame_00656	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Mame_00657	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Mame_00659	COG0166	Belongs to the GPI family
Mame_00660	COG0410	ABC transporter
Mame_00661	COG0411	ABC transporter
Mame_00663	COG0559	Belongs to the binding-protein-dependent transport system permease family
Mame_00669	COG1902	pentaerythritol trinitrate reductase activity
Mame_00671	COG0251	oxidation-reduction process
Mame_00681	COG1129	ABC transporter
Mame_00682	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_00683	COG1879	ABC-type sugar transport system periplasmic component
Mame_00684	COG1349	DNA-binding transcription factor activity
Mame_00687	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Mame_00690	COG0698	ribose 5-phosphate isomerase
Mame_00691	COG0149	triose-phosphate isomerase activity
Mame_00694	COG1609	Transcriptional regulator
Mame_00695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Mame_00696	COG2223	nitrite transmembrane transporter activity
Mame_00698	COG1846	Transcriptional regulator
Mame_00699	COG0697	spore germination
Mame_00700	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Mame_00701	COG0477	Major facilitator Superfamily
Mame_00702	COG3265	gluconokinase activity
Mame_00703	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Mame_00707	COG0135	phosphoribosylanthranilate isomerase activity
Mame_00708	COG0133	tryptophan synthase activity
Mame_00711	COG0159	tryptophan synthase activity
Mame_00712	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Mame_00715	COG1388	LysM domain
Mame_00715	COG1376	ErfK ybiS ycfS ynhG family protein
Mame_00716	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Mame_00718	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Mame_00719	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Mame_00725	COG0187	DNA topoisomerase II activity
Mame_00726	COG1732	Glycine betaine
Mame_00727	COG1174	glycine betaine transport
Mame_00728	COG1125	glycine betaine transport
Mame_00729	COG1174	glycine betaine transport
Mame_00732	COG1733	regulation of RNA biosynthetic process
Mame_00734	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Mame_00736	COG1733	regulation of RNA biosynthetic process
Mame_00739	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Mame_00740	COG0495	leucyl-tRNA aminoacylation
Mame_00743	COG1475	DNA binding
Mame_00744	COG1192	Involved in chromosome partitioning
Mame_00745	COG0357	Ribosomal RNA small subunit methyltransferase G
Mame_00746	COG0445	tRNA wobble uridine modification
Mame_00747	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Mame_00748	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Mame_00750	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Mame_00751	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Mame_00752	COG0424	maF-like protein
Mame_00753	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Mame_00755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Mame_00757	COG2390	Transcriptional regulator
Mame_00758	COG0019	diaminopimelate decarboxylase activity
Mame_00761	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Mame_00763	COG1643	Atp-dependent helicase
Mame_00765	COG2199	diguanylate cyclase activity
Mame_00765	COG2200	EAL domain
Mame_00765	COG3287	FIST C domain
Mame_00766	COG0673	inositol 2-dehydrogenase activity
Mame_00767	COG1609	Transcriptional regulator
Mame_00768	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Mame_00769	COG4989	oxidoreductase activity
Mame_00772	COG0307	riboflavin synthase, alpha
Mame_00774	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_00775	COG0137	argininosuccinate synthase activity
Mame_00779	COG0339	signal peptide processing
Mame_00781	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Mame_00782	COG5002	protein histidine kinase activity
Mame_00784	COG0573	inorganic phosphate transmembrane transporter activity
Mame_00786	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Mame_00787	COG0704	Plays a role in the regulation of phosphate uptake
Mame_00788	COG0745	RESPONSE REGULATOR receiver
Mame_00797	COG3145	DNA-N1-methyladenine dioxygenase activity
Mame_00800	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Mame_00801	COG0745	RESPONSE REGULATOR receiver
Mame_00802	COG2205	protein histidine kinase activity
Mame_00804	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Mame_00804	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Mame_00805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Mame_00812	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Mame_00818	COG4251	negative regulation of phosphorylation
Mame_00822	COG3030	protein affecting phage T7 exclusion by the F plasmid
Mame_00823	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Mame_00825	COG3842	ATPase activity
Mame_00826	COG1802	Transcriptional regulator
Mame_00827	COG0395	ABC-type sugar transport system, permease component
Mame_00831	COG4948	Mandelate Racemase Muconate Lactonizing
Mame_00835	COG3119	arylsulfatase activity
Mame_00836	COG1309	transcriptional regulator
Mame_00839	COG4175	Glycine betaine
Mame_00843	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Mame_00846	COG0673	inositol 2-dehydrogenase activity
Mame_00848	COG1024	Enoyl-CoA hydratase
Mame_00850	COG1653	transport
Mame_00851	COG1175	transmembrane transport
Mame_00853	COG3842	ATPase activity
Mame_00855	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_00859	COG0737	Belongs to the 5'-nucleotidase family
Mame_00860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Mame_00861	COG0330	HflC and HflK could
Mame_00862	COG1585	Membrane protein implicated in regulation of membrane protease activity
Mame_00870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mame_00871	COG0072	phenylalanine-tRNA ligase activity
Mame_00871	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mame_00873	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Mame_00874	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Mame_00876	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Mame_00877	COG1073	alpha beta
Mame_00879	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Mame_00882	COG3706	GGDEF domain
Mame_00883	COG0142	geranyltranstransferase activity
Mame_00884	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Mame_00885	COG0625	glutathione transferase activity
Mame_00886	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Mame_00887	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
Mame_00888	COG0183	Belongs to the thiolase family
Mame_00896	COG1329	Transcriptional regulator
Mame_00897	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Mame_00899	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
Mame_00904	COG1047	Peptidyl-prolyl cis-trans
Mame_00905	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Mame_00907	COG2943	transferase activity, transferring hexosyl groups
Mame_00914	COG0628	permease
Mame_00916	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_00917	COG1879	ABC-type sugar transport system periplasmic component
Mame_00919	COG0673	inositol 2-dehydrogenase activity
Mame_00921	COG3842	ATPase activity
Mame_00923	COG0395	ABC-type sugar transport system, permease component
Mame_00924	COG1175	transmembrane transport
Mame_00930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Mame_00931	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Mame_00937	COG2030	dehydratase
Mame_00942	COG1072	(Pantothenic acid kinase))
Mame_00943	COG0140	phosphoribosyl-ATP diphosphatase activity
Mame_00944	COG0107	imidazoleglycerol-phosphate synthase activity
Mame_00945	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Mame_00946	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Mame_00947	COG0131	Imidazoleglycerol-phosphate dehydratase
Mame_00950	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Mame_00952	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Mame_00953	COG0667	Aldo Keto reductase
Mame_00954	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Mame_00955	COG1802	Transcriptional regulator
Mame_00956	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mame_00957	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_00959	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Mame_00963	COG1176	ABC-type spermidine putrescine transport system, permease component I
Mame_00964	COG4149	molybdate abc transporter
Mame_00967	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Mame_00970	COG3250	beta-galactosidase activity
Mame_00971	COG1132	(ABC) transporter
Mame_00973	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Mame_00974	COG0489	protein tyrosine kinase activity
Mame_00975	COG3386	PFAM SMP-30 Gluconolaconase
Mame_00976	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Mame_00980	COG1215	transferase activity, transferring glycosyl groups
Mame_00988	COG0071	Belongs to the small heat shock protein (HSP20) family
Mame_00991	COG3220	belongs to the UPF0276 family
Mame_00994	COG0070	glutamate synthase
Mame_00994	COG0069	glutamate synthase activity
Mame_00994	COG0067	glutamate synthase
Mame_00996	COG1487	ribonuclease activity
Mame_00997	COG0393	Putative heavy-metal-binding
Mame_00999	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Mame_01002	COG1238	metal cluster binding
Mame_01005	COG3237	CsbD-like
Mame_01007	COG0784	Response regulator, receiver
Mame_01010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Mame_01011	COG1946	Acyl-CoA thioesterase
Mame_01012	COG0347	Belongs to the P(II) protein family
Mame_01013	COG0004	ammonium transporteR
Mame_01016	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Mame_01017	COG1295	ribonuclease BN
Mame_01018	COG0300	oxidoreductase activity
Mame_01019	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Mame_01022	COG2086	electron transfer activity
Mame_01023	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Mame_01024	COG0432	Pfam Uncharacterised protein family UPF0047
Mame_01026	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_01032	COG0667	Aldo Keto reductase
Mame_01033	COG0667	Aldo Keto reductase
Mame_01035	COG0387	Pfam Sodium calcium exchanger
Mame_01037	COG0729	surface antigen
Mame_01039	COG0156	8-amino-7-oxononanoate synthase activity
Mame_01041	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Mame_01042	COG1250	3-hydroxyacyl-CoA dehydrogenase
Mame_01046	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Mame_01047	COG0756	dUTP diphosphatase activity
Mame_01048	COG3174	membrane
Mame_01050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_01052	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mame_01056	COG0534	Mate efflux family protein
Mame_01058	COG0009	L-threonylcarbamoyladenylate synthase
Mame_01060	COG4638	Rieske (2fe-2S)
Mame_01062	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Mame_01063	COG3454	Phosphonate metabolism
Mame_01064	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Mame_01066	COG0670	Belongs to the BI1 family
Mame_01068	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Mame_01069	COG4181	ATPase activity
Mame_01071	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Mame_01072	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Mame_01073	COG2154	pterin-4-alpha-carbinolamine dehydratase
Mame_01076	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_01080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Mame_01082	COG2160	L-arabinose isomerase activity
Mame_01084	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_01085	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_01086	COG1129	ABC transporter
Mame_01087	COG1879	ABC-type sugar transport system periplasmic component
Mame_01089	COG0589	response to stress
Mame_01097	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Mame_01106	COG2308	Evidence 4 Homologs of previously reported genes of
Mame_01107	COG0513	Belongs to the DEAD box helicase family
Mame_01108	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mame_01108	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Mame_01115	COG4266	Belongs to the allantoicase family
Mame_01116	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
Mame_01119	COG1304	FMN binding
Mame_01120	COG0402	S-adenosylhomocysteine deaminase activity
Mame_01123	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Mame_01125	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_01128	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
Mame_01131	COG1160	GTP binding
Mame_01136	COG0438	transferase activity, transferring glycosyl groups
Mame_01136	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Mame_01137	COG0366	Alpha amylase catalytic
Mame_01138	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Mame_01143	COG4175	Glycine betaine
Mame_01144	COG1435	thymidine kinase activity
Mame_01145	COG2197	response regulator
Mame_01146	COG0281	malic enzyme
Mame_01146	COG0280	phosphate acetyltransferase
Mame_01147	COG2259	Doxx family
Mame_01150	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Mame_01156	COG1802	Transcriptional regulator
Mame_01156	COG4626	Terminase
Mame_01187	COG1230	cation diffusion facilitator family transporter
Mame_01189	COG0300	oxidoreductase activity
Mame_01191	COG0753	catalase activity
Mame_01192	COG0583	DNA-binding transcription factor activity
Mame_01195	COG2818	Glycosylase
Mame_01196	COG2855	membrane
Mame_01197	COG0583	DNA-binding transcription factor activity
Mame_01199	COG0124	histidyl-tRNA synthetase
Mame_01201	COG1294	oxidase, subunit
Mame_01202	COG1271	oxidase subunit
Mame_01203	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Mame_01204	COG4988	ABC transporter
Mame_01211	COG0583	DNA-binding transcription factor activity
Mame_01212	COG0583	DNA-binding transcription factor activity
Mame_01215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Mame_01217	COG0312	modulator of DNA gyrase
Mame_01218	COG0483	inositol monophosphate 1-phosphatase activity
Mame_01220	COG1519	Transferase
Mame_01221	COG1663	tetraacyldisaccharide 4'-kinase activity
Mame_01223	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Mame_01224	COG5310	Homospermidine synthase
Mame_01229	COG3108	Peptidase M15
Mame_01230	COG0640	Transcriptional regulator
Mame_01231	COG1609	Transcriptional regulator
Mame_01232	COG1653	transport
Mame_01233	COG1175	transmembrane transport
Mame_01234	COG0395	ABC-type sugar transport system, permease component
Mame_01235	COG0366	Alpha amylase catalytic
Mame_01236	COG3842	ATPase activity
Mame_01238	COG0129	dihydroxy-acid dehydratase activity
Mame_01239	COG0363	glucosamine-6-phosphate deaminase activity
Mame_01240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Mame_01241	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mame_01242	COG0174	glutamine synthetase
Mame_01243	COG2081	HI0933 family
Mame_01248	COG1278	Cold shock
Mame_01249	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Mame_01251	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Mame_01252	COG1115	amino acid carrier protein
Mame_01253	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Mame_01255	COG2986	histidine ammonia-lyase
Mame_01256	COG1228	amidohydrolase
Mame_01257	COG0402	S-adenosylhomocysteine deaminase activity
Mame_01259	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Mame_01260	COG1116	anion transmembrane transporter activity
Mame_01261	COG2188	Transcriptional regulator
Mame_01262	COG0588	phosphoglycerate mutase activity
Mame_01263	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Mame_01264	COG0837	glucose binding
Mame_01265	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
Mame_01266	COG4166	transmembrane transport
Mame_01267	COG4174	ABC transporter (Permease)
Mame_01268	COG4239	(ABC) transporter, permease
Mame_01269	COG4172	Belongs to the ABC transporter superfamily
Mame_01271	COG0559	Belongs to the binding-protein-dependent transport system permease family
Mame_01275	COG0829	nickel cation binding
Mame_01276	COG0831	urea catabolic process
Mame_01277	COG0832	Belongs to the urease beta subunit family
Mame_01279	COG0804	urea catabolic process
Mame_01281	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Mame_01282	COG0830	nickel cation binding
Mame_01283	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Mame_01287	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Mame_01288	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Mame_01289	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Mame_01292	COG0494	nUDIX hydrolase
Mame_01296	COG2852	Protein conserved in bacteria
Mame_01298	COG1309	transcriptional regulator
Mame_01301	COG0493	'glutamate synthase
Mame_01305	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Mame_01308	COG4206	TonB-dependent receptor
Mame_01310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mame_01311	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Mame_01312	COG0527	aspartate kinase activity
Mame_01314	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Mame_01315	COG2890	protein-(glutamine-N5) methyltransferase activity
Mame_01317	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Mame_01318	COG0539	negative regulation of cytoplasmic translation
Mame_01321	COG3383	formate dehydrogenase (NAD+) activity
Mame_01326	COG0463	Glycosyl transferase, family 2
Mame_01331	COG3436	PFAM IS66 Orf2 family protein
Mame_01332	COG4372	Transposase
Mame_01337	COG1484	DNA-dependent DNA replication
Mame_01344	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mame_01350	COG0582	viral genome integration into host DNA
Mame_01356	COG2900	Belongs to the SlyX family
Mame_01357	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Mame_01364	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Mame_01368	COG1175	transmembrane transport
Mame_01369	COG1653	transport
Mame_01370	COG1609	Transcriptional regulator
Mame_01371	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Mame_01373	COG4325	translation initiation factor activity
Mame_01379	COG3181	Tripartite tricarboxylate transporter family receptor
Mame_01386	COG2224	Isocitrate lyase
Mame_01389	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
Mame_01390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Mame_01391	COG4208	sulfate ABC transporter
Mame_01394	COG2084	Dehydrogenase
Mame_01399	COG0625	glutathione transferase activity
Mame_01400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Mame_01401	COG3800	Transcriptional regulator
Mame_01401	COG1396	sequence-specific DNA binding
Mame_01402	COG0583	DNA-binding transcription factor activity
Mame_01405	COG3153	acetyltransferase
Mame_01409	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Mame_01411	COG1528	Iron-storage protein
Mame_01412	COG1904	glucuronate isomerase
Mame_01413	COG1802	Transcriptional regulator
Mame_01414	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Mame_01417	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Mame_01420	COG4120	Belongs to the binding-protein-dependent transport system permease family
Mame_01423	COG2249	NAD(P)H dehydrogenase (quinone) activity
Mame_01425	COG0402	S-adenosylhomocysteine deaminase activity
Mame_01426	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Mame_01428	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Mame_01429	COG0583	DNA-binding transcription factor activity
Mame_01432	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Mame_01435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Mame_01436	COG0564	pseudouridine synthase activity
Mame_01448	COG3118	belongs to the thioredoxin family
Mame_01450	COG2835	tetraacyldisaccharide 4'-kinase activity
Mame_01456	COG0606	chelatase, subunit chli
Mame_01458	COG0189	ligase activity
Mame_01459	COG3842	ATPase activity
Mame_01460	COG0395	ABC-type sugar transport system, permease component
Mame_01461	COG1175	transmembrane transport
Mame_01462	COG1653	transport
Mame_01463	COG0792	nuclease activity
Mame_01464	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Mame_01465	COG0592	DNA-directed DNA polymerase activity
Mame_01466	COG0284	orotidine-5'-phosphate decarboxylase activity
Mame_01471	COG0494	nUDIX hydrolase
Mame_01473	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Mame_01474	COG0798	PFAM Bile acid sodium symporter
Mame_01479	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Mame_01481	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Mame_01482	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Mame_01483	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Mame_01486	COG2816	NAD+ diphosphatase activity
Mame_01489	COG0077	Prephenate dehydratase
Mame_01489	COG1605	Chorismate mutase
Mame_01490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Mame_01491	COG3474	cytochrome
Mame_01494	COG1136	(ABC) transporter
Mame_01499	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Mame_01500	COG0542	response to heat
Mame_01529	COG4977	sequence-specific DNA binding
Mame_01535	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mame_01536	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Mame_01537	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_01541	COG1960	acyl-CoA dehydrogenase activity
Mame_01542	COG0022	dehydrogenase e1 component
Mame_01543	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Mame_01545	COG3181	Tripartite tricarboxylate transporter family receptor
Mame_01549	COG2721	sulfolactate sulfo-lyase activity
Mame_01555	COG0642	Histidine kinase
Mame_01558	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Mame_01567	COG1129	ABC transporter
Mame_01568	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
Mame_01569	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Mame_01570	COG3959	Transketolase, thiamine diphosphate binding domain
Mame_01571	COG3958	Transketolase
Mame_01572	COG1850	ribulose-bisphosphate carboxylase activity
Mame_01574	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_01574	COG3347	Dehydrogenase
Mame_01575	COG1454	alcohol dehydrogenase
Mame_01576	COG1309	transcriptional regulator
Mame_01578	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_01580	COG0183	Belongs to the thiolase family
Mame_01585	COG0411	ABC transporter
Mame_01587	COG1024	Enoyl-CoA hydratase
Mame_01588	COG0318	PFAM AMP-dependent synthetase and ligase
Mame_01591	COG4585	Histidine kinase
Mame_01594	COG1129	ABC transporter
Mame_01595	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_01597	COG0667	Aldo Keto reductase
Mame_01598	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Mame_01605	COG2831	hemolysin activation secretion protein
Mame_01606	COG3210	domain, Protein
Mame_01609	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Mame_01610	COG4608	Belongs to the ABC transporter superfamily
Mame_01611	COG0444	Belongs to the ABC transporter superfamily
Mame_01612	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mame_01613	COG0601	transmembrane transport
Mame_01614	COG0747	negative chemotaxis
Mame_01620	COG1446	asparaginase
Mame_01626	COG1487	ribonuclease activity
Mame_01628	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mame_01629	COG0492	ferredoxin-NADP+ reductase activity
Mame_01633	COG0583	DNA-binding transcription factor activity
Mame_01634	COG1881	PFAM PEBP family protein
Mame_01637	COG0505	Belongs to the CarA family
Mame_01638	COG2258	MOSC domain
Mame_01639	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Mame_01640	COG3386	PFAM SMP-30 Gluconolaconase
Mame_01641	COG3246	L-lysine catabolic process to acetate
Mame_01642	COG1250	3-hydroxyacyl-CoA dehydrogenase
Mame_01643	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_01644	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_01645	COG1129	ABC transporter
Mame_01647	COG1802	Transcriptional regulator
Mame_01649	COG2070	2-Nitropropane dioxygenase
Mame_01655	COG1309	transcriptional regulator
Mame_01657	COG1921	L-seryl-tRNASec selenium transferase activity
Mame_01661	COG4172	Belongs to the ABC transporter superfamily
Mame_01662	COG3964	amidohydrolase
Mame_01664	COG0601	transmembrane transport
Mame_01667	COG1120	ATPase activity
Mame_01668	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mame_01670	COG2226	methyltransferase
Mame_01681	COG1278	Cold shock
Mame_01682	COG3239	Fatty acid desaturase
Mame_01683	COG1278	Cold shock
Mame_01688	COG0438	transferase activity, transferring glycosyl groups
Mame_01692	COG1215	transferase activity, transferring glycosyl groups
Mame_01697	COG0395	ABC-type sugar transport system, permease component
Mame_01698	COG1175	transmembrane transport
Mame_01702	COG2186	Transcriptional regulator
Mame_01703	COG0346	lactoylglutathione lyase activity
Mame_01704	COG0028	Belongs to the TPP enzyme family
Mame_01719	COG0583	DNA-binding transcription factor activity
Mame_01721	COG4221	oxidoreductase activity
Mame_01722	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Mame_01724	COG1984	allophanate hydrolase subunit 2
Mame_01725	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Mame_01729	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_01730	COG3265	gluconokinase activity
Mame_01731	COG1063	alcohol dehydrogenase
Mame_01732	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Mame_01734	COG2968	Membrane
Mame_01735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mame_01736	COG0842	Transport permease protein
Mame_01736	COG1129	ABC transporter
Mame_01737	COG0842	Transport permease protein
Mame_01738	COG0484	heat shock protein binding
Mame_01739	COG0443	Heat shock 70 kDa protein
Mame_01740	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Mame_01743	COG0800	Aldolase
Mame_01752	COG0793	Belongs to the peptidase S41A family
Mame_01754	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Mame_01755	COG0799	negative regulation of ribosome biogenesis
Mame_01757	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Mame_01758	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Mame_01759	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Mame_01760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Mame_01765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Mame_01766	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Mame_01771	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Mame_01773	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
Mame_01783	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
Mame_01789	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Mame_01794	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_01795	COG0625	glutathione transferase activity
Mame_01796	COG1733	regulation of RNA biosynthetic process
Mame_01802	COG1396	sequence-specific DNA binding
Mame_01803	COG0583	DNA-binding transcription factor activity
Mame_01804	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Mame_01809	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Mame_01810	COG1984	allophanate hydrolase subunit 2
Mame_01812	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Mame_01813	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mame_01814	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Mame_01819	COG2801	Transposase and inactivated derivatives
Mame_01827	COG1175	transmembrane transport
Mame_01828	COG1653	transport
Mame_01829	COG1609	Transcriptional regulator
Mame_01832	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Mame_01837	COG4948	Mandelate Racemase Muconate Lactonizing
Mame_01838	COG3655	Transcriptional regulator
Mame_01844	COG4166	transmembrane transport
Mame_01846	COG1454	alcohol dehydrogenase
Mame_01847	COG2186	Transcriptional regulator
Mame_01848	COG3395	kinase activity
Mame_01849	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Mame_01850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Mame_01851	COG1309	transcriptional regulator
Mame_01852	COG1960	acyl-CoA dehydrogenase activity
Mame_01853	COG1960	acyl-CoA dehydrogenase activity
Mame_01854	COG1024	Enoyl-CoA hydratase
Mame_01854	COG1250	3-hydroxyacyl-CoA dehydrogenase
Mame_01855	COG1960	acyl-CoA dehydrogenase activity
Mame_01856	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Mame_01857	COG3181	Tripartite tricarboxylate transporter family receptor
Mame_01860	COG0583	DNA-binding transcription factor activity
Mame_01865	COG0483	inositol monophosphate 1-phosphatase activity
Mame_01866	COG0483	inositol monophosphate 1-phosphatase activity
Mame_01870	COG3842	ATPase activity
Mame_01876	COG0243	molybdopterin cofactor binding
Mame_01877	COG0437	4 iron, 4 sulfur cluster binding
Mame_01878	COG3302	dmso reductase anchor subunit
Mame_01879	COG0446	pyridine nucleotide-disulphide oxidoreductase
Mame_01879	COG1902	pentaerythritol trinitrate reductase activity
Mame_01881	COG1120	ATPase activity
Mame_01882	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mame_01893	COG1840	ABC-type Fe3 transport system, periplasmic component
Mame_01894	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
Mame_01894	COG1940	carbohydrate kinase activity
Mame_01897	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_01898	COG1069	ribulokinase activity
Mame_01900	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_01902	COG1879	ABC-type sugar transport system periplasmic component
Mame_01904	COG1063	alcohol dehydrogenase
Mame_01905	COG1609	Transcriptional regulator
Mame_01906	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Mame_01907	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Mame_01910	COG1175	transmembrane transport
Mame_01911	COG0395	ABC-type sugar transport system, permease component
Mame_01914	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_01915	COG1609	Transcriptional regulator
Mame_01916	COG0673	inositol 2-dehydrogenase activity
Mame_01918	COG1653	transport
Mame_01921	COG3842	ATPase activity
Mame_01925	COG4974	Belongs to the 'phage' integrase family
Mame_01929	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Mame_01931	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Mame_01932	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Mame_01933	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Mame_01934	COG5001	Diguanylate cyclase
Mame_01936	COG0523	cobalamin synthesis protein
Mame_01937	COG1609	Transcriptional regulator
Mame_01941	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Mame_01942	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Mame_01943	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mame_01947	COG2814	Major facilitator Superfamily
Mame_01949	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Mame_01950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Mame_01951	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Mame_01958	COG2346	COG2346, Truncated hemoglobins
Mame_01961	COG1178	ABC-type Fe3 transport system permease component
Mame_01962	COG2205	protein histidine kinase activity
Mame_01966	COG1840	ABC-type Fe3 transport system, periplasmic component
Mame_01967	COG1959	2 iron, 2 sulfur cluster binding
Mame_01970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Mame_01971	COG1120	ATPase activity
Mame_01972	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mame_01973	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mame_01974	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Mame_01975	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Mame_01976	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Mame_01978	COG0069	glutamate synthase activity
Mame_01979	COG0531	amino acid
Mame_01980	COG2967	ApaG domain
Mame_01983	COG0717	Belongs to the dCTP deaminase family
Mame_01986	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Mame_01986	COG0519	Catalyzes the synthesis of GMP from XMP
Mame_01991	COG0181	hydroxymethylbilane synthase activity
Mame_01992	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Mame_01993	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Mame_01997	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Mame_02002	COG0416	fatty acid biosynthetic process
Mame_02003	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Mame_02004	COG0776	regulation of translation
Mame_02007	COG2326	polyphosphate kinase activity
Mame_02010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Mame_02011	COG0038	chloride channel
Mame_02012	COG1607	acyl-coa hydrolase
Mame_02015	COG1595	DNA-templated transcription, initiation
Mame_02016	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Mame_02018	COG1396	sequence-specific DNA binding
Mame_02019	COG0481	GTPase activity
Mame_02020	COG4536	flavin adenine dinucleotide binding
Mame_02021	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Mame_02022	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Mame_02023	COG4974	Belongs to the 'phage' integrase family
Mame_02024	COG0825	malonyl-CoA metabolic process
Mame_02026	COG0425	Belongs to the sulfur carrier protein TusA family
Mame_02026	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Mame_02027	COG0523	cobalamin synthesis protein
Mame_02029	COG1473	amidohydrolase
Mame_02039	COG2985	domain, Protein
Mame_02040	COG0387	Pfam Sodium calcium exchanger
Mame_02042	COG1289	transmembrane transporter activity
Mame_02046	COG2986	histidine ammonia-lyase
Mame_02046	COG1228	amidohydrolase
Mame_02048	COG2239	Acts as a magnesium transporter
Mame_02049	COG0076	glutamate decarboxylase activity
Mame_02050	COG2197	response regulator
Mame_02052	COG0601	transmembrane transport
Mame_02053	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mame_02058	COG0831	urea catabolic process
Mame_02060	COG0804	urea catabolic process
Mame_02062	COG0830	nickel cation binding
Mame_02063	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Mame_02064	COG0829	nickel cation binding
Mame_02066	COG0004	ammonium transporteR
Mame_02070	COG2985	domain, Protein
Mame_02073	COG2010	Cytochrome c
Mame_02074	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Mame_02075	COG1185	polyribonucleotide nucleotidyltransferase activity
Mame_02076	COG2813	Specifically methylates the guanine in position
Mame_02081	COG0066	3-isopropylmalate dehydratase activity
Mame_02082	COG2264	protein methyltransferase activity
Mame_02084	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Mame_02089	COG2845	Protein of unknown function (DUF459)
Mame_02090	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Mame_02091	COG0039	L-malate dehydrogenase activity
Mame_02092	COG0045	succinate-CoA ligase (ADP-forming) activity
Mame_02093	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Mame_02094	COG0567	Dehydrogenase, E1 component
Mame_02095	COG0508	dehydrogenase complex catalyzes the overall conversion of
Mame_02099	COG3038	cytochrome b561
Mame_02101	COG0431	NADPH-dependent FMN reductase
Mame_02101	COG3976	FMN-binding domain protein
Mame_02101	COG1053	succinate dehydrogenase
Mame_02102	COG0395	ABC-type sugar transport system, permease component
Mame_02107	COG2376	Dihydroxyacetone kinase
Mame_02108	COG1461	Dihydroxyacetone kinase
Mame_02109	COG2376	Dihydroxyacetone kinase
Mame_02110	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_02111	COG1879	ABC-type sugar transport system periplasmic component
Mame_02112	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_02113	COG1129	ABC transporter
Mame_02116	COG0517	IMP dehydrogenase activity
Mame_02116	COG0516	GMP reductase activity
Mame_02118	COG1477	protein flavinylation
Mame_02120	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Mame_02139	COG2072	flavoprotein involved in K transport
Mame_02144	COG1072	(Pantothenic acid kinase))
Mame_02145	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Mame_02145	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Mame_02145	COG0506	proline dehydrogenase activity
Mame_02146	COG1522	sequence-specific DNA binding
Mame_02147	COG1609	Transcriptional regulator
Mame_02148	COG0673	inositol 2-dehydrogenase activity
Mame_02150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Mame_02151	COG3962	Belongs to the TPP enzyme family
Mame_02153	COG3718	enzyme involved in inositol metabolism
Mame_02155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Mame_02158	COG0521	Mo-molybdopterin cofactor biosynthetic process
Mame_02159	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Mame_02161	COG0142	geranyltranstransferase activity
Mame_02166	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mame_02167	COG0752	glycyl-tRNA synthetase alpha subunit
Mame_02168	COG1704	LemA family
Mame_02169	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Mame_02172	COG0751	glycine-tRNA ligase activity
Mame_02176	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Mame_02177	COG2183	response to ionizing radiation
Mame_02178	COG0151	Belongs to the GarS family
Mame_02179	COG1674	ftsk spoiiie
Mame_02180	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Mame_02181	COG0708	Exodeoxyribonuclease III
Mame_02183	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Mame_02184	COG0424	maF-like protein
Mame_02185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Mame_02186	COG5328	Belongs to the UPF0262 family
Mame_02189	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Mame_02195	COG1278	Cold shock
Mame_02197	COG0589	response to stress
Mame_02198	COG0659	secondary active sulfate transmembrane transporter activity
Mame_02199	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Mame_02201	COG0326	Molecular chaperone. Has ATPase activity
Mame_02202	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mame_02203	COG0165	Argininosuccinate lyase
Mame_02209	COG2204	response regulator
Mame_02211	COG2884	Cell division ATP-binding protein ftsE
Mame_02215	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
Mame_02217	COG0287	Prephenate dehydrogenase
Mame_02218	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Mame_02219	COG2226	methyltransferase
Mame_02220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mame_02224	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Mame_02225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Mame_02226	COG0246	Mannitol dehydrogenase
Mame_02227	COG0366	Alpha amylase catalytic
Mame_02235	COG0561	phosphatase activity
Mame_02236	COG0438	transferase activity, transferring glycosyl groups
Mame_02239	COG0473	3-isopropylmalate dehydrogenase activity
Mame_02240	COG0671	phosphoesterase, PA-phosphatase related
Mame_02241	COG0671	phosphoesterase, PA-phosphatase related
Mame_02242	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Mame_02243	COG0288	reversible hydration of carbon dioxide
Mame_02245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Mame_02247	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Mame_02248	COG0583	DNA-binding transcription factor activity
Mame_02249	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Mame_02250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Mame_02251	COG3485	protocatechuate 3,4-dioxygenase
Mame_02252	COG3485	protocatechuate 3,4-dioxygenase
Mame_02253	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Mame_02255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Mame_02258	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_02259	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_02261	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mame_02262	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Mame_02263	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_02271	COG0697	spore germination
Mame_02273	COG1309	transcriptional regulator
Mame_02274	COG1309	transcriptional regulator
Mame_02276	COG4221	oxidoreductase activity
Mame_02278	COG1335	isochorismatase
Mame_02280	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_02281	COG2207	Transcriptional regulator
Mame_02284	COG0288	reversible hydration of carbon dioxide
Mame_02285	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Mame_02288	COG0138	bifunctional purine biosynthesis protein purh
Mame_02291	COG0501	Belongs to the peptidase M48B family
Mame_02297	COG0395	ABC-type sugar transport system, permease component
Mame_02298	COG1175	transmembrane transport
Mame_02303	COG0129	dihydroxy-acid dehydratase activity
Mame_02307	COG0662	Cupin 2, conserved barrel domain protein
Mame_02307	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Mame_02316	COG4372	Transposase
Mame_02319	COG1609	Transcriptional regulator
Mame_02321	COG1234	tRNA 3'-trailer cleavage
Mame_02323	COG1840	ABC-type Fe3 transport system, periplasmic component
Mame_02324	COG3842	ATPase activity
Mame_02325	COG0583	DNA-binding transcription factor activity
Mame_02330	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_02331	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_02332	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mame_02333	COG1063	alcohol dehydrogenase
Mame_02336	COG2010	Cytochrome c
Mame_02337	COG3909	cytochrome
Mame_02339	COG0352	thiamine-phosphate diphosphorylase activity
Mame_02340	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Mame_02346	COG0126	phosphoglycerate kinase activity
Mame_02347	COG3263	regulation of cellular component size
Mame_02348	COG0477	Major facilitator Superfamily
Mame_02349	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Mame_02352	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Mame_02353	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Mame_02354	COG0706	membrane insertase activity
Mame_02356	COG5002	protein histidine kinase activity
Mame_02359	COG0745	RESPONSE REGULATOR receiver
Mame_02359	COG3706	GGDEF domain
Mame_02360	COG1215	transferase activity, transferring glycosyl groups
Mame_02361	COG3769	mannosylglycerate metabolic process
Mame_02362	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Mame_02365	COG3706	GGDEF domain
Mame_02366	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Mame_02368	COG1476	TRANSCRIPTIONal
Mame_02372	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Mame_02373	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Mame_02374	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mame_02376	COG0739	heme binding
Mame_02377	COG1414	Transcriptional regulator
Mame_02381	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Mame_02382	COG0028	Belongs to the TPP enzyme family
Mame_02386	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Mame_02387	COG0477	Major facilitator Superfamily
Mame_02393	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Mame_02396	COG0530	calcium, potassium:sodium antiporter activity
Mame_02398	COG0534	Mate efflux family protein
Mame_02399	COG0114	fumarate hydratase activity
Mame_02401	COG0546	phosphoglycolate phosphatase activity
Mame_02402	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Mame_02407	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Mame_02409	COG0823	Involved in the tonB-independent uptake of proteins
Mame_02412	COG1127	ABC transporter
Mame_02415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Mame_02416	COG1090	epimerase
Mame_02419	COG0824	Thioesterase
Mame_02423	COG0823	Involved in the tonB-independent uptake of proteins
Mame_02424	COG2885	chlorophyll binding
Mame_02426	COG0037	tRNA processing
Mame_02427	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mame_02428	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Mame_02433	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Mame_02434	COG5001	Diguanylate cyclase
Mame_02434	COG3300	MHYT domain
Mame_02437	COG3811	Belongs to the UPF0386 family
Mame_02438	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mame_02443	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Mame_02446	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Mame_02448	COG0436	Aminotransferase
Mame_02449	COG1530	ribonuclease E activity
Mame_02449	COG1530	ribonuclease E activity
Mame_02450	COG0860	N-Acetylmuramoyl-L-alanine amidase
Mame_02451	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Mame_02454	COG4106	trans-aconitate 2-methyltransferase activity
Mame_02459	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mame_02461	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mame_02466	COG2001	Belongs to the MraZ family
Mame_02467	COG0275	rRNA processing
Mame_02470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Mame_02471	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Mame_02472	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Mame_02473	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Mame_02475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Mame_02476	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Mame_02478	COG1181	Belongs to the D-alanine--D-alanine ligase family
Mame_02479	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Mame_02480	COG0849	cell division
Mame_02481	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Mame_02483	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Mame_02484	COG0497	DNA recombination
Mame_02485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Mame_02487	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Mame_02489	COG3791	Glutathione-dependent formaldehyde-activating
Mame_02490	COG1999	signal sequence binding
Mame_02491	COG2264	protein methyltransferase activity
Mame_02494	COG0583	DNA-binding transcription factor activity
Mame_02497	COG0673	inositol 2-dehydrogenase activity
Mame_02499	COG0277	FAD linked oxidase domain protein
Mame_02501	COG2832	Protein of unknown function (DUF454)
Mame_02505	COG0395	ABC-type sugar transport system, permease component
Mame_02506	COG3842	ATPase activity
Mame_02508	COG0673	inositol 2-dehydrogenase activity
Mame_02510	COG0667	Aldo Keto reductase
Mame_02512	COG1121	(ABC) transporter
Mame_02513	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Mame_02515	COG5001	Diguanylate cyclase
Mame_02515	COG3706	GGDEF domain
Mame_02515	COG2203	Gaf domain
Mame_02515	COG4251	negative regulation of phosphorylation
Mame_02517	COG0179	Fumarylacetoacetate (FAA) hydrolase
Mame_02518	COG3706	GGDEF domain
Mame_02519	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Mame_02520	COG0037	tRNA processing
Mame_02521	COG2066	Belongs to the glutaminase family
Mame_02522	COG1695	Transcriptional regulator
Mame_02524	COG2897	thiosulfate sulfurtransferase activity
Mame_02527	COG0415	Belongs to the DNA photolyase family
Mame_02528	COG1376	ErfK ybiS ycfS ynhG family protein
Mame_02531	COG0251	oxidation-reduction process
Mame_02541	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Mame_02542	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Mame_02543	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Mame_02546	COG1612	heme a metabolic process
Mame_02548	COG1737	Transcriptional regulator
Mame_02552	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Mame_02553	COG0174	glutamine synthetase
Mame_02559	COG0442	prolyl-tRNA aminoacylation
Mame_02561	COG1136	(ABC) transporter
Mame_02570	COG4372	Transposase
Mame_02571	COG3436	PFAM IS66 Orf2 family protein
Mame_02595	COG4373	Mu-like prophage FluMu protein gp28
Mame_02597	COG0640	Transcriptional regulator
Mame_02611	COG2842	Transposition protein
Mame_02612	COG2801	Transposase and inactivated derivatives
Mame_02622	COG4191	Histidine kinase
Mame_02627	COG0586	Pfam SNARE associated Golgi protein
Mame_02628	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Mame_02630	COG1215	transferase activity, transferring glycosyl groups
Mame_02632	COG0633	Ferredoxin
Mame_02632	COG3217	Mosc domain protein beta barrel domain protein
Mame_02633	COG0668	transmembrane transport
Mame_02635	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Mame_02636	COG0354	folic acid binding
Mame_02638	COG0494	nUDIX hydrolase
Mame_02640	COG1183	phosphatidylcholine synthase activity
Mame_02641	COG0688	phosphatidylethanolamine metabolic process
Mame_02642	COG5265	(ABC) transporter
Mame_02646	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mame_02650	COG0215	cysteine-tRNA ligase activity
Mame_02655	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_02656	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Mame_02659	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Mame_02660	COG0305	Participates in initiation and elongation during chromosome replication
Mame_02662	COG0359	binds to the 23S rRNA
Mame_02664	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Mame_02665	COG0360	Binds together with S18 to 16S ribosomal RNA
Mame_02669	COG0667	Aldo Keto reductase
Mame_02670	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Mame_02672	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mame_02673	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mame_02674	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Mame_02675	COG1561	YicC-like family, N-terminal region
Mame_02676	COG0194	GDP metabolic process
Mame_02677	COG3119	arylsulfatase activity
Mame_02678	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Mame_02682	COG1653	transport
Mame_02684	COG0673	inositol 2-dehydrogenase activity
Mame_02686	COG0587	DNA-directed DNA polymerase activity
Mame_02687	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Mame_02691	COG2233	PERMEase
Mame_02693	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Mame_02694	COG0018	arginyl-trna synthetase
Mame_02696	COG1472	Belongs to the glycosyl hydrolase 3 family
Mame_02697	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Mame_02698	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Mame_02699	COG3842	ATPase activity
Mame_02700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Mame_02701	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Mame_02702	COG0805	protein transport
Mame_02714	COG0625	glutathione transferase activity
Mame_02719	COG0330	HflC and HflK could
Mame_02724	COG0560	Phosphoserine phosphatase
Mame_02725	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Mame_02726	COG0028	Belongs to the TPP enzyme family
Mame_02730	COG0556	nucleotide-excision repair
Mame_02732	COG1607	acyl-coa hydrolase
Mame_02734	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Mame_02737	COG1595	DNA-templated transcription, initiation
Mame_02739	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Mame_02740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Mame_02741	COG0702	epimerase
Mame_02742	COG1733	regulation of RNA biosynthetic process
Mame_02744	COG0047	phosphoribosylformylglycinamidine synthase activity
Mame_02745	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Mame_02746	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Mame_02748	COG0303	'Molybdopterin
Mame_02749	COG0315	cyclic pyranopterin monophosphate synthase activity
Mame_02751	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Mame_02755	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Mame_02756	COG0148	phosphopyruvate hydratase activity
Mame_02758	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Mame_02759	COG0022	dehydrogenase e1 component
Mame_02759	COG0508	dehydrogenase complex catalyzes the overall conversion of
Mame_02760	COG0508	dehydrogenase complex catalyzes the overall conversion of
Mame_02763	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mame_02765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Mame_02766	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Mame_02768	COG0546	phosphoglycolate phosphatase activity
Mame_02770	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Mame_02771	COG1671	Belongs to the UPF0178 family
Mame_02773	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Mame_02775	COG0321	lipoyl(octanoyl) transferase activity
Mame_02777	COG2860	membrane
Mame_02778	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_02782	COG1129	ABC transporter
Mame_02783	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_02786	COG1137	ATPase activity
Mame_02787	COG0410	ABC transporter
Mame_02795	COG1802	Transcriptional regulator
Mame_02803	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Mame_02804	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mame_02807	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mame_02811	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Mame_02812	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Mame_02818	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Mame_02819	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Mame_02820	COG1012	belongs to the aldehyde dehydrogenase family
Mame_02821	COG1522	sequence-specific DNA binding
Mame_02822	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Mame_02823	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_02824	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Mame_02825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mame_02826	COG0589	response to stress
Mame_02828	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Mame_02829	COG2423	ornithine cyclodeaminase activity
Mame_02830	COG0006	proline dipeptidase activity
Mame_02831	COG1063	alcohol dehydrogenase
Mame_02833	COG0434	BtpA family
Mame_02834	COG1349	DNA-binding transcription factor activity
Mame_02837	COG0395	ABC-type sugar transport system, permease component
Mame_02840	COG2072	flavoprotein involved in K transport
Mame_02848	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Mame_02849	COG1176	ABC-type spermidine putrescine transport system, permease component I
Mame_02852	COG1335	isochorismatase
Mame_02854	COG0154	amidase activity
Mame_02856	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mame_02857	COG0402	S-adenosylhomocysteine deaminase activity
Mame_02858	COG0583	DNA-binding transcription factor activity
Mame_02862	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Mame_02863	COG3842	ATPase activity
Mame_02867	COG1959	2 iron, 2 sulfur cluster binding
Mame_02873	COG4771	TonB-dependent receptor
Mame_02875	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
Mame_02876	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mame_02877	COG2911	Protein conserved in bacteria
Mame_02877	COG3210	domain, Protein
Mame_02878	COG1309	transcriptional regulator
Mame_02879	COG4774	siderophore transport
Mame_02889	COG2814	Major facilitator Superfamily
Mame_02892	COG1741	Belongs to the pirin family
Mame_02893	COG0400	carboxylic ester hydrolase activity
Mame_02894	COG0346	lactoylglutathione lyase activity
Mame_02895	COG0583	DNA-binding transcription factor activity
Mame_02897	COG2010	Cytochrome c
Mame_02897	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Mame_02898	COG2080	2 iron, 2 sulfur cluster binding
Mame_02899	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Mame_02899	COG2010	Cytochrome c
Mame_02901	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Mame_02904	COG4977	sequence-specific DNA binding
Mame_02904	COG1917	Cupin 2, conserved barrel domain protein
Mame_02908	COG0243	molybdopterin cofactor binding
Mame_02909	COG4566	intracellular signal transduction
Mame_02910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Mame_02912	COG4566	intracellular signal transduction
Mame_02913	COG4566	intracellular signal transduction
Mame_02914	COG2205	protein histidine kinase activity
Mame_02914	COG0745	RESPONSE REGULATOR receiver
Mame_02914	COG4191	Histidine kinase
Mame_02916	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Mame_02923	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Mame_02925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mame_02926	COG0084	hydrolase, TatD family'
Mame_02927	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Mame_02927	COG0321	lipoyl(octanoyl) transferase activity
Mame_02928	COG3842	ATPase activity
Mame_02930	COG1176	ABC-type spermidine putrescine transport system, permease component I
Mame_02934	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Mame_02937	COG1595	DNA-templated transcription, initiation
Mame_02938	COG3806	Anti-sigma factor
Mame_02942	COG3180	Ammonia monooxygenase
Mame_02945	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Mame_02945	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Mame_02946	COG0509	glycine decarboxylation via glycine cleavage system
Mame_02947	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Mame_02949	COG2867	negative regulation of translational initiation
Mame_02950	COG1546	Belongs to the CinA family
Mame_02951	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Mame_02951	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Mame_02953	COG3852	Histidine kinase
Mame_02954	COG2204	response regulator
Mame_02955	COG5000	phosphorelay sensor kinase activity
Mame_02956	COG2204	response regulator
Mame_02957	COG0569	domain protein
Mame_02958	COG1923	regulation of RNA biosynthetic process
Mame_02959	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Mame_02960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Mame_02961	COG0789	Transcriptional regulator
Mame_02962	COG3956	TIGRFAM MazG family protein
Mame_02964	COG1648	precorrin-2 dehydrogenase activity
Mame_02964	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Mame_02966	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Mame_02969	COG0577	efflux transmembrane transporter activity
Mame_02969	COG1136	(ABC) transporter
Mame_02970	COG1136	(ABC) transporter
Mame_02970	COG0577	efflux transmembrane transporter activity
Mame_02971	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mame_02972	COG5342	invasion associated locus B
Mame_02974	COG0343	queuine tRNA-ribosyltransferase activity
Mame_02975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Mame_02977	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Mame_02978	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Mame_02979	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Mame_02980	COG2095	MarC family integral membrane protein
Mame_02981	COG0629	single-stranded DNA binding
Mame_02982	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Mame_02984	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Mame_02984	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Mame_02985	COG0347	Belongs to the P(II) protein family
Mame_02986	COG0174	glutamine synthetase
Mame_02990	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Mame_02991	COG2264	protein methyltransferase activity
Mame_02992	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Mame_02993	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Mame_02994	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Mame_02999	COG1321	iron dependent repressor
Mame_03000	COG1914	H( )-stimulated, divalent metal cation uptake system
Mame_03002	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Mame_03004	COG0514	ATP-dependent DNA helicase (RecQ)
Mame_03007	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Mame_03008	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Mame_03010	COG1802	Transcriptional regulator
Mame_03013	COG0525	valine-tRNA ligase activity
Mame_03015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Mame_03018	COG0668	transmembrane transport
Mame_03021	COG1473	amidohydrolase
Mame_03022	COG0747	negative chemotaxis
Mame_03024	COG4172	Belongs to the ABC transporter superfamily
Mame_03028	COG2197	response regulator
Mame_03031	COG0183	Belongs to the thiolase family
Mame_03034	COG0484	heat shock protein binding
Mame_03035	COG4175	Glycine betaine
Mame_03035	COG0517	IMP dehydrogenase activity
Mame_03036	COG4176	ABC-type proline glycine betaine transport system permease component
Mame_03037	COG2113	Glycine betaine
Mame_03038	COG2271	Major facilitator Superfamily
Mame_03039	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Mame_03040	COG1522	sequence-specific DNA binding
Mame_03042	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Mame_03044	COG5002	protein histidine kinase activity
Mame_03044	COG5001	Diguanylate cyclase
Mame_03044	COG3447	MASE1 domain protein
Mame_03045	COG0776	regulation of translation
Mame_03046	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Mame_03047	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Mame_03048	COG0740	serine-type endopeptidase activity
Mame_03049	COG2199	diguanylate cyclase activity
Mame_03052	COG1832	CoA-binding protein
Mame_03055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Mame_03056	COG0573	inorganic phosphate transmembrane transporter activity
Mame_03057	COG0581	inorganic phosphate transmembrane transporter activity
Mame_03058	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Mame_03061	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Mame_03062	COG0671	phosphoesterase, PA-phosphatase related
Mame_03067	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Mame_03068	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Mame_03069	COG1381	Involved in DNA repair and RecF pathway recombination
Mame_03070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Mame_03071	COG0571	ribonuclease III activity
Mame_03072	COG0681	Belongs to the peptidase S26 family
Mame_03073	COG0736	holo-[acyl-carrier-protein] synthase activity
Mame_03077	COG1758	RNA polymerase activity
Mame_03079	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Mame_03080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Mame_03081	COG0741	lytic transglycosylase activity
Mame_03085	COG1278	Cold shock
Mame_03086	COG0346	lactoylglutathione lyase activity
Mame_03089	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Mame_03091	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mame_03093	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Mame_03094	COG0436	Aminotransferase
Mame_03097	COG1489	DNA binding
Mame_03098	COG0024	Methionine aminopeptidase
Mame_03099	COG2003	Belongs to the UPF0758 family
Mame_03103	COG0544	peptidyl-prolyl cis-trans isomerase activity
Mame_03105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Mame_03114	COG2801	Transposase and inactivated derivatives
Mame_03115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Mame_03119	COG1484	DNA-dependent DNA replication
Mame_03120	COG4584	PFAM Integrase catalytic
Mame_03126	COG0679	Auxin Efflux Carrier
Mame_03127	COG0785	Cytochrome C biogenesis protein
Mame_03130	COG0471	metal ion transport
Mame_03130	COG3273	potassium ion transport
Mame_03132	COG0384	phenazine biosynthesis protein PhzF
Mame_03139	COG1129	ABC transporter
Mame_03140	COG1183	phosphatidylcholine synthase activity
Mame_03142	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Mame_03142	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Mame_03144	COG0297	glycogen (starch) synthase activity
Mame_03147	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Mame_03154	COG0640	Transcriptional regulator
Mame_03155	COG0405	Gamma-glutamyltransferase
Mame_03158	COG1309	transcriptional regulator
Mame_03161	COG3181	Tripartite tricarboxylate transporter family receptor
Mame_03164	COG0673	inositol 2-dehydrogenase activity
Mame_03166	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Mame_03167	COG2333	competence protein COMEC
Mame_03167	COG0658	competence protein
Mame_03168	COG0372	Belongs to the citrate synthase family
Mame_03169	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mame_03171	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mame_03172	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Mame_03173	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Mame_03174	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Mame_03175	COG0750	zinc metalloprotease
Mame_03177	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Mame_03178	COG0233	cytoplasmic translational termination
Mame_03179	COG0528	UMP kinase activity
Mame_03180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Mame_03181	COG0052	Belongs to the universal ribosomal protein uS2 family
Mame_03186	COG0537	adenosine 5'-monophosphoramidase activity
Mame_03187	COG1285	pathogenesis
Mame_03188	COG4717	serine-type aminopeptidase activity
Mame_03189	COG0420	3'-5' exonuclease activity
Mame_03190	COG0667	Aldo Keto reductase
Mame_03192	COG0697	spore germination
Mame_03193	COG0583	DNA-binding transcription factor activity
Mame_03194	COG0346	lactoylglutathione lyase activity
Mame_03195	COG0400	carboxylic ester hydrolase activity
Mame_03196	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Mame_03198	COG4172	Belongs to the ABC transporter superfamily
Mame_03200	COG0601	transmembrane transport
Mame_03201	COG0747	negative chemotaxis
Mame_03202	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Mame_03203	COG1737	Transcriptional regulator
Mame_03205	COG0659	secondary active sulfate transmembrane transporter activity
Mame_03206	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Mame_03207	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Mame_03208	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Mame_03212	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
Mame_03213	COG1012	belongs to the aldehyde dehydrogenase family
Mame_03214	COG0410	ABC transporter
Mame_03219	COG0583	DNA-binding transcription factor activity
Mame_03221	COG0604	alcohol dehydrogenase
Mame_03221	COG3321	synthase
Mame_03221	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_03222	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_03223	COG4172	Belongs to the ABC transporter superfamily
Mame_03225	COG0601	transmembrane transport
Mame_03227	COG1250	3-hydroxyacyl-CoA dehydrogenase
Mame_03227	COG0824	Thioesterase
Mame_03228	COG3246	L-lysine catabolic process to acetate
Mame_03231	COG0697	spore germination
Mame_03236	COG3119	arylsulfatase activity
Mame_03237	COG3842	ATPase activity
Mame_03238	COG0395	ABC-type sugar transport system, permease component
Mame_03239	COG1175	transmembrane transport
Mame_03241	COG0583	DNA-binding transcription factor activity
Mame_03243	COG3300	MHYT domain
Mame_03243	COG5001	Diguanylate cyclase
Mame_03246	COG0745	RESPONSE REGULATOR receiver
Mame_03247	COG2205	protein histidine kinase activity
Mame_03249	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_03250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mame_03252	COG0583	DNA-binding transcription factor activity
Mame_03254	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Mame_03255	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Mame_03256	COG0765	amino acid transport
Mame_03257	COG0765	amino acid transport
Mame_03258	COG1126	abc transporter atp-binding protein
Mame_03259	COG1902	pentaerythritol trinitrate reductase activity
Mame_03259	COG0446	pyridine nucleotide-disulphide oxidoreductase
Mame_03260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Mame_03262	COG0494	nUDIX hydrolase
Mame_03263	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Mame_03264	COG0625	glutathione transferase activity
Mame_03267	COG0322	excinuclease ABC activity
Mame_03268	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Mame_03269	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Mame_03270	COG0314	molybdopterin synthase activity
Mame_03272	COG0105	UTP biosynthetic process
Mame_03276	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Mame_03278	COG0739	heme binding
Mame_03279	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Mame_03280	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Mame_03281	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Mame_03282	COG0747	negative chemotaxis
Mame_03287	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mame_03290	COG4172	Belongs to the ABC transporter superfamily
Mame_03292	COG1129	ABC transporter
Mame_03293	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_03294	COG2376	Dihydroxyacetone kinase
Mame_03297	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Mame_03299	COG0165	Argininosuccinate lyase
Mame_03300	COG0395	ABC-type sugar transport system, permease component
Mame_03301	COG1175	transmembrane transport
Mame_03302	COG2182	Extracellular solute-binding protein
Mame_03303	COG1940	carbohydrate kinase activity
Mame_03308	COG0604	alcohol dehydrogenase
Mame_03309	COG2313	pseudouridylate synthase activity
Mame_03310	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Mame_03310	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Mame_03311	COG0538	isocitrate dehydrogenase activity
Mame_03313	COG1012	belongs to the aldehyde dehydrogenase family
Mame_03317	COG1410	methionine synthase
Mame_03317	COG0646	methionine synthase
Mame_03319	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Mame_03322	COG1007	ATP synthesis coupled electron transport
Mame_03325	COG0713	ATP synthesis coupled electron transport
Mame_03327	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mame_03328	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Mame_03331	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Mame_03332	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Mame_03333	COG0649	NAD binding
Mame_03334	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mame_03335	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mame_03336	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mame_03341	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Mame_03342	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Mame_03343	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Mame_03344	COG0271	Belongs to the BolA IbaG family
Mame_03345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Mame_03346	COG2814	Major facilitator Superfamily
Mame_03348	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_03350	COG0483	inositol monophosphate 1-phosphatase activity
Mame_03351	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Mame_03353	COG0686	Belongs to the AlaDH PNT family
Mame_03354	COG1522	sequence-specific DNA binding
Mame_03356	COG0737	Belongs to the 5'-nucleotidase family
Mame_03360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Mame_03362	COG3106	COG3106 Predicted ATPase
Mame_03363	COG3768	UPF0283 membrane protein
Mame_03365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Mame_03366	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Mame_03367	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Mame_03368	COG0633	Ferredoxin
Mame_03372	COG0612	Peptidase, M16
Mame_03376	COG1678	Uncharacterized ACR, COG1678
Mame_03378	COG0678	peroxiredoxin activity
Mame_03381	COG0328	RNA-DNA hybrid ribonuclease activity
Mame_03382	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Mame_03383	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Mame_03385	COG3346	SURF1 family
Mame_03389	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Mame_03391	COG0109	protoheme IX farnesyltransferase activity
Mame_03392	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Mame_03395	COG0312	modulator of DNA gyrase
Mame_03398	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Mame_03400	COG4702	Belongs to the UPF0303 family
Mame_03401	COG0259	pyridoxamine-phosphate oxidase activity
Mame_03402	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Mame_03403	COG0406	alpha-ribazole phosphatase activity
Mame_03404	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Mame_03413	COG1522	sequence-specific DNA binding
Mame_03414	COG0492	ferredoxin-NADP+ reductase activity
Mame_03415	COG0583	DNA-binding transcription factor activity
Mame_03416	COG1902	pentaerythritol trinitrate reductase activity
Mame_03417	COG0387	Pfam Sodium calcium exchanger
Mame_03418	COG4221	oxidoreductase activity
Mame_03419	COG0583	DNA-binding transcription factor activity
Mame_03423	COG2133	pyrroloquinoline quinone binding
Mame_03425	COG1278	Cold shock
Mame_03426	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Mame_03427	COG0358	DNA primase activity
Mame_03429	COG0505	Belongs to the CarA family
Mame_03433	COG0387	Pfam Sodium calcium exchanger
Mame_03436	COG2151	metal-sulfur cluster biosynthetic enzyme
Mame_03437	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Mame_03438	COG0719	Fe-S assembly protein
Mame_03439	COG0396	ATPase activity
Mame_03441	COG0719	Fe-S assembly protein
Mame_03442	COG1104	cysteine desulfurase activity
Mame_03443	COG2945	thiolester hydrolase activity
Mame_03446	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Mame_03448	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Mame_03449	COG0513	Belongs to the DEAD box helicase family
Mame_03450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Mame_03454	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Mame_03456	COG5001	Diguanylate cyclase
Mame_03457	COG0504	CTP synthase activity
Mame_03458	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Mame_03459	COG0149	triose-phosphate isomerase activity
Mame_03460	COG0187	DNA topoisomerase II activity
Mame_03464	COG1376	ErfK ybiS ycfS ynhG family protein
Mame_03468	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Mame_03473	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Mame_03475	COG1522	sequence-specific DNA binding
Mame_03476	COG1573	uracil-dna glycosylase
Mame_03477	COG2205	protein histidine kinase activity
Mame_03479	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Mame_03480	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Mame_03481	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Mame_03483	COG0730	response to heat
Mame_03490	COG0626	cystathionine gamma-synthase activity
Mame_03491	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Mame_03492	COG4597	amino acid ABC transporter
Mame_03493	COG0765	amino acid transport
Mame_03494	COG1126	abc transporter atp-binding protein
Mame_03499	COG0254	rRNA binding
Mame_03500	COG1132	(ABC) transporter
Mame_03501	COG0697	spore germination
Mame_03505	COG0483	inositol monophosphate 1-phosphatase activity
Mame_03506	COG3706	GGDEF domain
Mame_03510	COG3750	Belongs to the UPF0335 family
Mame_03514	COG0469	pyruvate kinase activity
Mame_03517	COG1760	l-serine dehydratase
Mame_03522	COG2239	Acts as a magnesium transporter
Mame_03525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Mame_03526	COG0625	glutathione transferase activity
Mame_03527	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Mame_03530	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_03537	COG0308	aminopeptidase N
Mame_03539	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Mame_03540	COG2205	protein histidine kinase activity
Mame_03541	COG0745	RESPONSE REGULATOR receiver
Mame_03542	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Mame_03543	COG3088	subunit of a heme lyase
Mame_03544	COG1138	Cytochrome C-type biogenesis protein
Mame_03545	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Mame_03546	COG4235	cytochrome complex assembly
Mame_03548	COG0642	Histidine kinase
Mame_03549	COG0745	RESPONSE REGULATOR receiver
Mame_03564	COG4695	Portal protein
Mame_03568	COG2983	Belongs to the UPF0260 family
Mame_03570	COG0559	Belongs to the binding-protein-dependent transport system permease family
Mame_03579	COG2166	iron-sulfur cluster assembly
Mame_03581	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Mame_03582	COG4957	zinc ion binding
Mame_03583	COG1320	monovalent cation:proton antiporter activity
Mame_03584	COG2212	antiporter activity
Mame_03585	COG1863	multisubunit Na H antiporter MnhE subunit
Mame_03587	COG1006	Multisubunit Na H antiporter MnhC subunit
Mame_03588	COG2111	Na H antiporter
Mame_03589	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Mame_03589	COG2111	Na H antiporter
Mame_03590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Mame_03592	COG0784	Response regulator, receiver
Mame_03595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Mame_03597	COG0028	Belongs to the TPP enzyme family
Mame_03598	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mame_03602	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_03603	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Mame_03605	COG4529	Protein conserved in bacteria
Mame_03606	COG0405	Gamma-glutamyltransferase
Mame_03607	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Mame_03608	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Mame_03609	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Mame_03610	COG2989	Protein conserved in bacteria
Mame_03612	COG0113	porphobilinogen synthase activity
Mame_03614	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Mame_03615	COG1970	mechanosensitive ion channel activity
Mame_03621	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Mame_03623	COG2169	Transcriptional regulator
Mame_03624	COG1486	melibiose metabolic process
Mame_03625	COG1349	DNA-binding transcription factor activity
Mame_03626	COG2971	BadF BadG BcrA BcrD
Mame_03628	COG1175	transmembrane transport
Mame_03630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Mame_03631	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
Mame_03632	COG3842	ATPase activity
Mame_03633	COG1129	ABC transporter
Mame_03634	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_03636	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Mame_03637	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Mame_03641	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Mame_03647	COG0217	transcriptional regulatory protein
Mame_03649	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Mame_03651	COG0667	Aldo Keto reductase
Mame_03652	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Mame_03653	COG0632	four-way junction helicase activity
Mame_03654	COG2002	toxin-antitoxin pair type II binding
Mame_03656	COG2255	four-way junction helicase activity
Mame_03658	COG0628	permease
Mame_03659	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Mame_03660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Mame_03662	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mame_03663	COG1846	Transcriptional regulator
Mame_03664	COG0745	RESPONSE REGULATOR receiver
Mame_03665	COG2205	protein histidine kinase activity
Mame_03667	COG4585	Histidine kinase
Mame_03668	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_03669	COG4948	Mandelate Racemase Muconate Lactonizing
Mame_03671	COG2017	converts alpha-aldose to the beta-anomer
Mame_03672	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_03673	COG1129	ABC transporter
Mame_03674	COG1879	ABC-type sugar transport system periplasmic component
Mame_03675	COG2186	Transcriptional regulator
Mame_03676	COG3734	2-keto-3-deoxy-galactonokinase
Mame_03677	COG0800	Aldolase
Mame_03681	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mame_03682	COG0583	DNA-binding transcription factor activity
Mame_03685	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Mame_03697	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_03698	COG1733	regulation of RNA biosynthetic process
Mame_03700	COG4589	Belongs to the CDS family
Mame_03706	COG0395	ABC-type sugar transport system, permease component
Mame_03711	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_03713	COG1120	ATPase activity
Mame_03714	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mame_03715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mame_03716	COG4607	ABC-type enterochelin transport system periplasmic component
Mame_03717	COG4774	siderophore transport
Mame_03719	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
Mame_03720	COG1960	acyl-CoA dehydrogenase activity
Mame_03721	COG1024	Enoyl-CoA hydratase
Mame_03723	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Mame_03727	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_03728	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_03730	COG1960	acyl-CoA dehydrogenase activity
Mame_03731	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Mame_03731	COG1042	CoA-binding domain protein
Mame_03731	COG0045	succinate-CoA ligase (ADP-forming) activity
Mame_03732	COG1024	Enoyl-CoA hydratase
Mame_03733	COG3181	Tripartite tricarboxylate transporter family receptor
Mame_03735	COG0583	DNA-binding transcription factor activity
Mame_03736	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Mame_03739	COG0426	domain, Protein
Mame_03740	COG0574	Belongs to the PEP-utilizing enzyme family
Mame_03740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Mame_03741	COG1196	nuclear chromosome segregation
Mame_03746	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Mame_03750	COG1692	metallophosphoesterase
Mame_03761	COG2171	N-acyltransferase activity
Mame_03762	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Mame_03765	COG0431	NADPH-dependent FMN reductase
Mame_03766	COG1393	Belongs to the ArsC family
Mame_03767	COG0101	tRNA pseudouridine synthase activity
Mame_03768	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Mame_03769	COG0242	peptide deformylase activity
Mame_03771	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Mame_03772	COG4214	carbohydrate transport
Mame_03774	COG4213	ABC transporter substrate-binding protein
Mame_03775	COG4213	ABC transporter substrate-binding protein
Mame_03781	COG0318	PFAM AMP-dependent synthetase and ligase
Mame_03782	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Mame_03789	COG0625	glutathione transferase activity
Mame_03790	COG2205	protein histidine kinase activity
Mame_03792	COG0745	RESPONSE REGULATOR receiver
Mame_03793	COG3214	Protein conserved in bacteria
Mame_03794	COG1122	ATPase activity
Mame_03795	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Mame_03796	COG1268	BioY protein
Mame_03798	COG1722	exodeoxyribonuclease VII activity
Mame_03799	COG1741	Belongs to the pirin family
Mame_03800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Mame_03801	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Mame_03802	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Mame_03806	COG1733	regulation of RNA biosynthetic process
Mame_03807	COG0740	serine-type endopeptidase activity
Mame_03808	COG0667	Aldo Keto reductase
Mame_03809	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Mame_03810	COG0512	Glutamine amidotransferase of anthranilate synthase
Mame_03810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Mame_03811	COG0653	protein targeting
Mame_03812	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Mame_03813	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Mame_03815	COG0494	nUDIX hydrolase
Mame_03816	COG2226	methyltransferase
Mame_03817	COG1040	competence protein
Mame_03818	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Mame_03819	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mame_03823	COG1764	response to oxidative stress
Mame_03824	COG1846	Transcriptional regulator
Mame_03826	COG1063	alcohol dehydrogenase
Mame_03829	COG0175	sulfate reduction
Mame_03830	COG1609	Transcriptional regulator
Mame_03832	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Mame_03833	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Mame_03836	COG1131	(ABC) transporter
Mame_03837	COG0842	Transport permease protein
Mame_03841	COG0058	SHG alpha-glucan phosphorylase activity
Mame_03842	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Mame_03843	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Mame_03844	COG0297	glycogen (starch) synthase activity
Mame_03845	COG0033	Phosphoglucomutase
Mame_03846	COG1523	belongs to the glycosyl hydrolase 13 family
Mame_03850	COG0446	pyridine nucleotide-disulphide oxidoreductase
Mame_03850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Mame_03852	COG0596	Alpha beta hydrolase
Mame_03853	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mame_03859	COG3720	iron ion transport
Mame_03860	COG4558	Periplasmic binding protein
Mame_03861	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mame_03862	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Mame_03863	COG0742	ribosomal rna small subunit methyltransferase
Mame_03864	COG1187	pseudouridine synthase activity
Mame_03865	COG0590	tRNA wobble adenosine to inosine editing
Mame_03866	COG0456	acetyltransferase
Mame_03868	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Mame_03869	COG0196	riboflavin kinase activity
Mame_03872	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Mame_03873	COG0459	protein refolding
Mame_03877	COG3685	Protein conserved in bacteria
Mame_03878	COG0625	glutathione transferase activity
Mame_03880	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Mame_03881	COG0183	Belongs to the thiolase family
Mame_03882	COG1414	Transcriptional regulator
Mame_03883	COG0583	DNA-binding transcription factor activity
Mame_03890	COG0583	DNA-binding transcription factor activity
Mame_03891	COG0277	FAD linked oxidase domain protein
Mame_03892	COG0277	FAD linked oxidase domain protein
Mame_03894	COG0247	lactate metabolic process
Mame_03895	COG1957	nucleoside hydrolase
Mame_03896	COG0071	Belongs to the small heat shock protein (HSP20) family
Mame_03898	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Mame_03899	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Mame_03900	COG1396	sequence-specific DNA binding
Mame_03901	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Mame_03902	COG1253	flavin adenine dinucleotide binding
Mame_03903	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Mame_03904	COG1702	phosphate starvation-inducible protein PhoH
Mame_03905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Mame_03909	COG1214	PFAM Peptidase M22, glycoprotease
Mame_03910	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Mame_03912	COG0180	Tryptophanyl-tRNA synthetase
Mame_03915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Mame_03917	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Mame_03918	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Mame_03919	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Mame_03919	COG0116	Belongs to the methyltransferase superfamily
Mame_03921	COG0776	regulation of translation
Mame_03923	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Mame_03924	COG1137	ATPase activity
Mame_03925	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Mame_03926	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Mame_03927	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Mame_03929	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Mame_03930	COG1420	regulation of RNA biosynthetic process
Mame_03931	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Mame_03933	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Mame_03934	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Mame_03936	COG0482	sulfurtransferase activity
Mame_03938	COG0655	NAD(P)H dehydrogenase (quinone) activity
Mame_03939	COG1058	Belongs to the CinA family
Mame_03939	COG1546	Belongs to the CinA family
Mame_03941	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Mame_03943	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Mame_03947	COG0129	dihydroxy-acid dehydratase activity
Mame_03951	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Mame_03952	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Mame_03953	COG3739	integral membrane protein
Mame_03955	COG0203	ribosomal protein L17
Mame_03956	COG0202	RNA polymerase activity
Mame_03957	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Mame_03958	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Mame_03959	COG0563	adenylate kinase activity
Mame_03960	COG0201	protein transport
Mame_03961	COG0200	Binds to the 23S rRNA
Mame_03962	COG1841	ribosomal large subunit assembly
Mame_03963	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Mame_03964	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Mame_03965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Mame_03966	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Mame_03967	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Mame_03968	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Mame_03969	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Mame_03970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Mame_03971	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Mame_03972	COG0255	Belongs to the universal ribosomal protein uL29 family
Mame_03973	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Mame_03974	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Mame_03975	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Mame_03976	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Mame_03977	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Mame_03978	COG0089	rRNA binding
Mame_03979	COG0088	Forms part of the polypeptide exit tunnel
Mame_03980	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Mame_03981	COG0051	transcription antitermination factor activity, RNA binding
Mame_03982	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Mame_03983	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Mame_03984	COG0049	tRNA binding
Mame_03985	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Mame_03989	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Mame_03991	COG1280	lysine exporter protein (LysE YggA)
Mame_03992	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Mame_03993	COG0085	RNA polymerase activity
Mame_03994	COG0222	ribosome binding
Mame_03995	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Mame_03996	COG0081	regulation of translation
Mame_03997	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Mame_04002	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Mame_04002	COG3264	Mechanosensitive ion channel
Mame_04004	COG0628	permease
Mame_04006	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Mame_04008	COG0746	molybdenum cofactor guanylyltransferase activity
Mame_04009	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mame_04010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Mame_04012	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Mame_04016	COG1686	Belongs to the peptidase S11 family
Mame_04018	COG2885	chlorophyll binding
Mame_04019	COG2885	chlorophyll binding
Mame_04020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Mame_04021	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mame_04022	COG0210	DNA helicase
Mame_04023	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mame_04028	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Mame_04033	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Mame_04035	COG1335	isochorismatase
Mame_04038	COG0006	proline dipeptidase activity
Mame_04040	COG1960	acyl-CoA dehydrogenase activity
Mame_04041	COG0540	Belongs to the ATCase OTCase family
Mame_04043	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Mame_04044	COG0758	DNA mediated transformation
Mame_04044	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Mame_04046	COG1754	DNA topoisomerase type I activity
Mame_04046	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Mame_04047	COG0557	exoribonuclease II activity
Mame_04048	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Mame_04049	COG3300	MHYT domain
Mame_04049	COG5001	Diguanylate cyclase
Mame_04050	COG0193	aminoacyl-tRNA hydrolase activity
Mame_04051	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Mame_04052	COG0012	GTP binding
Mame_04053	COG0386	Belongs to the glutathione peroxidase family
Mame_04054	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Mame_04055	COG2857	Cytochrome c1
Mame_04055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Mame_04058	COG1132	(ABC) transporter
Mame_04059	COG1132	(ABC) transporter
Mame_04060	COG1289	transmembrane transporter activity
Mame_04063	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Mame_04065	COG0408	coproporphyrinogen oxidase activity
Mame_04068	COG0617	tRNA 3'-terminal CCA addition
Mame_04071	COG0714	Associated with various cellular activities
Mame_04076	COG0435	Glutathione S-transferase
Mame_04080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mame_04082	COG3135	benzoate transporter
Mame_04083	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Mame_04085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Mame_04085	COG0195	Participates in both transcription termination and antitermination
Mame_04086	COG0779	Required for maturation of 30S ribosomal subunits
Mame_04087	COG2814	Major facilitator Superfamily
Mame_04088	COG2951	lytic endotransglycosylase activity
Mame_04090	COG1968	undecaprenyl-diphosphatase activity
Mame_04092	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Mame_04097	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Mame_04098	COG0791	NLP P60 protein
Mame_04100	COG2217	Heavy metal translocating P-type atpase
Mame_04102	COG1280	lysine exporter protein (LysE YggA)
Mame_04104	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Mame_04108	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Mame_04110	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Mame_04119	COG0300	oxidoreductase activity
Mame_04121	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Mame_04122	COG0587	DNA-directed DNA polymerase activity
Mame_04125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Mame_04126	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Mame_04126	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Mame_04127	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Mame_04127	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Mame_04129	COG5507	3-demethylubiquinone-9 3-methyltransferase
Mame_04131	COG1312	Catalyzes the dehydration of D-mannonate
Mame_04132	COG1802	Transcriptional regulator
Mame_04133	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_04134	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mame_04134	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Mame_04135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mame_04136	COG3706	GGDEF domain
Mame_04137	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_04140	COG2951	lytic endotransglycosylase activity
Mame_04141	COG3206	protein involved in exopolysaccharide biosynthesis
Mame_04141	COG0489	protein tyrosine kinase activity
Mame_04143	COG1819	glycosyl
Mame_04144	COG1218	3'(2'),5'-bisphosphate nucleotidase
Mame_04145	COG0529	Catalyzes the synthesis of activated sulfate
Mame_04145	COG2895	sulfate adenylyltransferase (ATP) activity
Mame_04146	COG0175	sulfate reduction
Mame_04150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Mame_04151	COG0159	tryptophan synthase activity
Mame_04152	COG0133	tryptophan synthase activity
Mame_04153	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_04154	COG1129	ABC transporter
Mame_04157	COG0159	tryptophan synthase activity
Mame_04163	COG0583	DNA-binding transcription factor activity
Mame_04164	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mame_04167	COG0601	transmembrane transport
Mame_04168	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mame_04172	COG1648	precorrin-2 dehydrogenase activity
Mame_04172	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Mame_04174	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Mame_04175	COG1116	anion transmembrane transporter activity
Mame_04175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Mame_04177	COG1116	anion transmembrane transporter activity
Mame_04177	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Mame_04178	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Mame_04179	COG3707	response regulator
Mame_04180	COG0243	molybdopterin cofactor binding
Mame_04183	COG2346	COG2346, Truncated hemoglobins
Mame_04184	COG0521	Mo-molybdopterin cofactor biosynthetic process
Mame_04185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Mame_04188	COG2181	nitrate reductase activity
Mame_04189	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Mame_04190	COG1140	nitrate reductase beta subunit
Mame_04191	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Mame_04192	COG2223	nitrite transmembrane transporter activity
Mame_04194	COG0583	DNA-binding transcription factor activity
Mame_04195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Mame_04197	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Mame_04198	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mame_04199	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Mame_04200	COG1024	Enoyl-CoA hydratase
Mame_04201	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Mame_04202	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Mame_04205	COG0246	Mannitol dehydrogenase
Mame_04206	COG2721	sulfolactate sulfo-lyase activity
Mame_04207	COG1063	alcohol dehydrogenase
Mame_04208	COG1129	ABC transporter
Mame_04210	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_04211	COG1802	Transcriptional regulator
Mame_04212	COG3119	arylsulfatase activity
Mame_04214	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Mame_04215	COG0765	amino acid transport
Mame_04216	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Mame_04218	COG0335	large ribosomal subunit rRNA binding
Mame_04220	COG0336	Belongs to the RNA methyltransferase TrmD family
Mame_04221	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Mame_04222	COG0228	four-way junction DNA binding
Mame_04223	COG0287	Prephenate dehydrogenase
Mame_04223	COG1605	Chorismate mutase
Mame_04224	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Mame_04229	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Mame_04232	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Mame_04233	COG0552	protein localization to endoplasmic reticulum
Mame_04234	COG2917	probably involved in intracellular septation
Mame_04237	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Mame_04238	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Mame_04239	COG4133	protoheme IX ABC transporter activity
Mame_04240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Mame_04245	COG0730	response to heat
Mame_04249	COG1201	RNA secondary structure unwinding
Mame_04255	COG0167	dihydroorotate dehydrogenase activity
Mame_04265	COG2205	protein histidine kinase activity
Mame_04265	COG0784	Response regulator, receiver
Mame_04268	COG1085	galactose-1-phosphate uridylyltransferase
Mame_04269	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Mame_04271	COG1121	(ABC) transporter
Mame_04272	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Mame_04273	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Mame_04274	COG0418	dihydroorotase activity
Mame_04275	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Mame_04275	COG2755	lipolytic protein G-D-S-L family
Mame_04276	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Mame_04277	COG2814	Major facilitator Superfamily
Mame_04279	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Mame_04280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Mame_04281	COG1253	flavin adenine dinucleotide binding
Mame_04285	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Mame_04286	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Mame_04287	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Mame_04290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Mame_04291	COG1725	Transcriptional regulator
Mame_04292	COG1509	lysine 2,3-aminomutase activity
Mame_04293	COG2814	Major facilitator Superfamily
Mame_04295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Mame_04296	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Mame_04298	COG0457	Tetratricopeptide repeat
Mame_04299	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Mame_04300	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Mame_04301	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Mame_04304	COG5642	Protein of unknown function (DUF2384)
Mame_04306	COG0583	DNA-binding transcription factor activity
Mame_04307	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Mame_04309	COG1794	racemase activity, acting on amino acids and derivatives
Mame_04310	COG4521	taurine ABC transporter
Mame_04311	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Mame_04312	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Mame_04314	COG2267	carboxylic ester hydrolase activity
Mame_04318	COG1132	(ABC) transporter
Mame_04320	COG4783	chaperone-mediated protein folding
Mame_04325	COG0642	Histidine kinase
Mame_04331	COG1063	alcohol dehydrogenase
Mame_04336	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Mame_04336	COG0519	Catalyzes the synthesis of GMP from XMP
Mame_04337	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Mame_04339	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Mame_04344	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Mame_04344	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Mame_04345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Mame_04346	COG2226	methyltransferase
Mame_04347	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Mame_04348	COG0028	Belongs to the TPP enzyme family
Mame_04349	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Mame_04350	COG0268	Binds directly to 16S ribosomal RNA
Mame_04351	COG1192	Involved in chromosome partitioning
Mame_04352	COG1475	DNA binding
Mame_04353	COG0640	Transcriptional regulator
Mame_04358	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Mame_04359	COG1522	sequence-specific DNA binding
Mame_04360	COG1794	racemase activity, acting on amino acids and derivatives
Mame_04367	COG2072	flavoprotein involved in K transport
Mame_04368	COG2070	2-Nitropropane dioxygenase
Mame_04368	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Mame_04369	COG2091	lysine biosynthetic process via aminoadipic acid
Mame_04373	COG0179	Fumarylacetoacetate (FAA) hydrolase
Mame_04374	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_04376	COG2721	sulfolactate sulfo-lyase activity
Mame_04377	COG3254	rhamnose metabolic process
Mame_04379	COG1129	ABC transporter
Mame_04381	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_04382	COG1879	ABC-type sugar transport system periplasmic component
Mame_04384	COG0318	PFAM AMP-dependent synthetase and ligase
Mame_04384	COG0300	oxidoreductase activity
Mame_04384	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Mame_04384	COG3321	synthase
Mame_04384	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_04385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Mame_04385	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_04385	COG3321	synthase
Mame_04385	COG0318	PFAM AMP-dependent synthetase and ligase
Mame_04385	COG0300	oxidoreductase activity
Mame_04386	COG0300	oxidoreductase activity
Mame_04386	COG0318	PFAM AMP-dependent synthetase and ligase
Mame_04386	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Mame_04386	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_04386	COG3321	synthase
Mame_04387	COG0318	PFAM AMP-dependent synthetase and ligase
Mame_04394	COG4608	Belongs to the ABC transporter superfamily
Mame_04395	COG0444	Belongs to the ABC transporter superfamily
Mame_04397	COG0405	Gamma-glutamyltransferase
Mame_04398	COG1802	Transcriptional regulator
Mame_04401	COG0306	phosphate transporter
Mame_04405	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_04407	COG1609	Transcriptional regulator
Mame_04408	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
Mame_04409	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Mame_04410	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_04411	COG1129	ABC transporter
Mame_04414	COG1176	ABC-type spermidine putrescine transport system, permease component I
Mame_04415	COG1177	transmembrane transport
Mame_04416	COG3842	ATPase activity
Mame_04419	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Mame_04423	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_04426	COG1309	transcriptional regulator
Mame_04429	COG1252	NADH dehydrogenase
Mame_04430	COG3546	catalase activity
Mame_04432	COG0437	4 iron, 4 sulfur cluster binding
Mame_04439	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Mame_04447	COG3685	Protein conserved in bacteria
Mame_04450	COG2124	cytochrome p450
Mame_04467	COG2032	superoxide dismutase activity
Mame_04473	COG1309	transcriptional regulator
Mame_04474	COG3300	MHYT domain
Mame_04474	COG5001	Diguanylate cyclase
Mame_04476	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_04480	COG2132	Multicopper oxidase
Mame_04490	COG1175	transmembrane transport
Mame_04491	COG0395	ABC-type sugar transport system, permease component
Mame_04493	COG2188	Transcriptional regulator
Mame_04494	COG4821	SIS domain
Mame_04495	COG3842	ATPase activity
Mame_04496	COG1335	isochorismatase
Mame_04498	COG1116	anion transmembrane transporter activity
Mame_04499	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Mame_04501	COG1802	Transcriptional regulator
Mame_04504	COG0145	ligase activity
Mame_04505	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
Mame_04506	COG4647	ligase activity
Mame_04509	COG0747	negative chemotaxis
Mame_04511	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mame_04513	COG0006	proline dipeptidase activity
Mame_04514	COG1959	2 iron, 2 sulfur cluster binding
Mame_04520	COG0395	ABC-type sugar transport system, permease component
Mame_04521	COG3842	ATPase activity
Mame_04524	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Mame_04526	COG3436	PFAM IS66 Orf2 family protein
Mame_04527	COG4372	Transposase
Mame_04537	COG3459	Glycosyltransferase 36 associated
Mame_04541	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mame_04542	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Mame_04543	COG0745	RESPONSE REGULATOR receiver
Mame_04544	COG5000	phosphorelay sensor kinase activity
Mame_04544	COG5002	protein histidine kinase activity
Mame_04546	COG1024	Enoyl-CoA hydratase
Mame_04551	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Mame_04557	COG1250	3-hydroxyacyl-CoA dehydrogenase
Mame_04557	COG1024	Enoyl-CoA hydratase
Mame_04566	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_04569	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mame_04570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mame_04578	COG2188	Transcriptional regulator
Mame_04579	COG2986	histidine ammonia-lyase
Mame_04583	COG1174	glycine betaine transport
Mame_04584	COG1174	glycine betaine transport
Mame_04590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Mame_04593	COG3384	dioxygenase
Mame_04594	COG0402	S-adenosylhomocysteine deaminase activity
Mame_04595	COG1414	Transcriptional regulator
Mame_04597	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Mame_04602	COG1042	CoA-binding domain protein
Mame_04602	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Mame_04602	COG0045	succinate-CoA ligase (ADP-forming) activity
Mame_04607	COG1053	succinate dehydrogenase
Mame_04613	COG0559	Belongs to the binding-protein-dependent transport system permease family
Mame_04618	COG1414	Transcriptional regulator
Mame_04621	COG0235	Class ii aldolase
Mame_04623	COG1309	transcriptional regulator
Mame_04627	COG1960	acyl-CoA dehydrogenase activity
Mame_04628	COG1024	Enoyl-CoA hydratase
Mame_04628	COG1250	3-hydroxyacyl-CoA dehydrogenase
Mame_04629	COG0183	Belongs to the thiolase family
Mame_04630	COG0789	Transcriptional regulator
Mame_04631	COG0318	PFAM AMP-dependent synthetase and ligase
Mame_04632	COG0824	Thioesterase
Mame_04636	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_04640	COG1414	Transcriptional regulator
Mame_04641	COG0028	Belongs to the TPP enzyme family
Mame_04648	COG1522	sequence-specific DNA binding
Mame_04650	COG0508	dehydrogenase complex catalyzes the overall conversion of
Mame_04651	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Mame_04653	COG0179	Fumarylacetoacetate (FAA) hydrolase
Mame_04658	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Mame_04660	COG1414	Transcriptional regulator
Mame_04662	COG1802	Transcriptional regulator
Mame_04663	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_04668	COG0747	negative chemotaxis
Mame_04669	COG0601	transmembrane transport
Mame_04670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mame_04672	COG4608	Belongs to the ABC transporter superfamily
Mame_04675	COG2171	N-acyltransferase activity
Mame_04684	COG0395	ABC-type sugar transport system, permease component
Mame_04685	COG3842	ATPase activity
Mame_04686	COG0584	glycerophosphoryl diester phosphodiesterase
Mame_04688	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Mame_04692	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_04693	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Mame_04694	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mame_04696	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Mame_04700	COG0392	lysyltransferase activity
Mame_04701	COG3158	transport of potassium into the cell
Mame_04703	COG4952	isomerase
Mame_04704	COG3347	Dehydrogenase
Mame_04704	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_04705	COG1349	DNA-binding transcription factor activity
Mame_04707	COG1129	ABC transporter
Mame_04708	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_04709	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_04712	COG1802	Transcriptional regulator
Mame_04713	COG4948	Mandelate Racemase Muconate Lactonizing
Mame_04715	COG1175	transmembrane transport
Mame_04716	COG0395	ABC-type sugar transport system, permease component
Mame_04719	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_04720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Mame_04721	COG1024	Enoyl-CoA hydratase
Mame_04722	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_04724	COG1129	ABC transporter
Mame_04726	COG1609	Transcriptional regulator
Mame_04731	COG2824	Alkylphosphonate utilization operon protein PhnA
Mame_04732	COG3254	rhamnose metabolic process
Mame_04736	COG1175	transmembrane transport
Mame_04737	COG0395	ABC-type sugar transport system, permease component
Mame_04739	COG4948	Mandelate Racemase Muconate Lactonizing
Mame_04740	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_04741	COG4948	Mandelate Racemase Muconate Lactonizing
Mame_04744	COG0287	Prephenate dehydrogenase
Mame_04749	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_04750	COG1129	ABC transporter
Mame_04752	COG1879	ABC-type sugar transport system periplasmic component
Mame_04753	COG1850	ribulose-bisphosphate carboxylase activity
Mame_04756	COG0702	epimerase
Mame_04764	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mame_04768	COG1609	Transcriptional regulator
Mame_04770	COG0656	L-ascorbic acid biosynthetic process
Mame_04771	COG1175	transmembrane transport
Mame_04774	COG1653	transport
Mame_04778	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Mame_04779	COG3842	ATPase activity
Mame_04781	COG0395	ABC-type sugar transport system, permease component
Mame_04782	COG1175	transmembrane transport
Mame_04783	COG1653	transport
Mame_04784	COG4948	Mandelate Racemase Muconate Lactonizing
Mame_04785	COG1414	Transcriptional regulator
Mame_04786	COG4948	Mandelate Racemase Muconate Lactonizing
Mame_04788	COG0463	Glycosyl transferase, family 2
Mame_04790	COG0745	RESPONSE REGULATOR receiver
Mame_04791	COG2205	protein histidine kinase activity
Mame_04795	COG0133	tryptophan synthase activity
Mame_04798	COG0702	epimerase
Mame_04799	COG1733	regulation of RNA biosynthetic process
Mame_04801	COG0583	DNA-binding transcription factor activity
Mame_04806	COG0673	inositol 2-dehydrogenase activity
Mame_04810	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_04811	COG1733	regulation of RNA biosynthetic process
Mame_04816	COG1940	carbohydrate kinase activity
Mame_04819	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Mame_04820	COG3119	arylsulfatase activity
Mame_04823	COG3119	arylsulfatase activity
Mame_04825	COG1175	transmembrane transport
Mame_04836	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Mame_04837	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Mame_04838	COG1012	belongs to the aldehyde dehydrogenase family
Mame_04841	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Mame_04842	COG0583	DNA-binding transcription factor activity
Mame_04847	COG2207	Transcriptional regulator
Mame_04848	COG4221	oxidoreductase activity
Mame_04851	COG1959	2 iron, 2 sulfur cluster binding
Mame_04853	COG0251	oxidation-reduction process
Mame_04856	COG1879	ABC-type sugar transport system periplasmic component
Mame_04857	COG1172	Belongs to the binding-protein-dependent transport system permease family
Mame_04858	COG1129	ABC transporter
Mame_04860	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Mame_04865	COG0747	negative chemotaxis
Mame_04867	COG0601	transmembrane transport
Mame_04868	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mame_04870	COG3622	Belongs to the hyi family
Mame_04871	COG2084	Dehydrogenase
Mame_04875	COG1674	ftsk spoiiie
Mame_04875	COG2261	transglycosylase associated protein
Mame_04876	COG3279	Response regulator of the LytR AlgR family
Mame_04877	COG2972	Histidine kinase
Mame_04877	COG0745	RESPONSE REGULATOR receiver
Mame_04880	COG1192	Involved in chromosome partitioning
Mame_04882	COG0640	Transcriptional regulator
Mame_04888	COG1230	cation diffusion facilitator family transporter
Mame_04896	COG3547	Transposase (IS116 IS110 IS902 family)
Mame_04906	COG3831	ATPase activity
Mame_04908	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Mame_04910	COG1111	helicase
Mame_04910	COG1205	dead DEAH box helicase
Mame_04912	COG3177	Filamentation induced by cAMP protein fic
Mame_04918	COG3505	Type IV secretory pathway VirD4
Mame_04925	COG2948	multi-organism process
Mame_04929	COG0739	heme binding
Mame_04929	COG0741	lytic transglycosylase activity
Mame_04929	COG1196	nuclear chromosome segregation
Mame_04931	COG3451	type IV secretory pathway VirB4
Mame_04934	COG0739	heme binding
Mame_04934	COG1196	nuclear chromosome segregation
Mame_04934	COG0741	lytic transglycosylase activity
Mame_04939	COG4584	PFAM Integrase catalytic
Mame_04940	COG1484	DNA-dependent DNA replication
Mame_04943	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
Mame_04944	COG0640	Transcriptional regulator
Mame_04945	COG1475	DNA binding
Mame_04946	COG1192	Involved in chromosome partitioning
Mame_04947	COG1376	ErfK ybiS ycfS ynhG family protein
Mame_04979	COG1999	signal sequence binding
Mame_04983	COG1742	UPF0060 membrane protein
Mame_04985	COG2805	Type II/IV secretion system protein
Mame_04992	COG3831	ATPase activity
Mame_04993	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Mame_04994	COG3657	addiction module killer protein
Mame_04996	COG2184	nucleotidyltransferase activity
Mame_05001	COG0431	NADPH-dependent FMN reductase
Mame_05002	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Mame_05004	COG0745	RESPONSE REGULATOR receiver
Mame_05005	COG0704	Plays a role in the regulation of phosphate uptake
Mame_05007	COG4584	PFAM Integrase catalytic
Mame_05009	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mame_05015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Mame_05015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Mame_05017	COG2132	Multicopper oxidase
Mame_05018	COG2010	Cytochrome c
Mame_05026	COG1230	cation diffusion facilitator family transporter
Mame_05029	COG4235	cytochrome complex assembly
Mame_05030	COG3088	subunit of a heme lyase
Mame_05031	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Mame_05032	COG1138	Cytochrome C-type biogenesis protein
Mame_05035	COG2205	protein histidine kinase activity
Mame_05036	COG0745	RESPONSE REGULATOR receiver
Mame_05041	COG0398	Pfam SNARE associated Golgi protein
Mame_05042	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Mame_05043	COG2020	methyltransferase activity
Mame_05044	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Mame_05045	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Mame_05046	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Mame_05051	COG4584	PFAM Integrase catalytic
Mame_05057	COG2072	flavoprotein involved in K transport
Mame_05059	COG0785	Cytochrome C biogenesis protein
Mame_05060	COG1999	signal sequence binding
Mame_05061	COG1230	cation diffusion facilitator family transporter
Mame_05064	COG3547	Transposase (IS116 IS110 IS902 family)
Mame_05065	COG2801	Transposase and inactivated derivatives
Mame_05065	COG3415	Transposase
Mame_05069	COG0842	Transport permease protein
Mame_05070	COG0842	Transport permease protein
Mame_05070	COG1129	ABC transporter
Mame_05071	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Mame_05074	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Mame_05075	COG3328	transposase activity
Mame_05082	COG2433	Pfam Transposase IS66
Mame_05083	COG1940	carbohydrate kinase activity
Mame_05088	COG1335	isochorismatase
Mame_05098	COG1250	3-hydroxyacyl-CoA dehydrogenase
Mame_05102	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Mame_05104	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Mame_05107	COG3547	Transposase (IS116 IS110 IS902 family)
Mame_05114	COG3311	Transcriptional regulator
Mame_05116	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Mame_05119	COG1192	Involved in chromosome partitioning
Mame_05120	COG1475	DNA binding
Mame_05121	COG0640	Transcriptional regulator
Mame_05124	COG1487	ribonuclease activity
Mame_05128	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Mame_05137	COG3401	FG-GAP repeat protein
Mame_05140	COG1082	Xylose isomerase domain protein TIM barrel
Mame_05144	COG1175	transmembrane transport
Mame_05145	COG0395	ABC-type sugar transport system, permease component
Mame_05146	COG1063	alcohol dehydrogenase
Mame_05148	COG0277	FAD linked oxidase domain protein
Mame_05149	COG3842	ATPase activity
Mame_05151	COG4948	Mandelate Racemase Muconate Lactonizing
Mame_05152	COG4948	Mandelate Racemase Muconate Lactonizing
Mame_05154	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mame_05155	COG0601	transmembrane transport
Mame_05156	COG0747	negative chemotaxis
Mame_05157	COG2186	Transcriptional regulator
Mame_05162	COG0765	amino acid transport
Mame_05163	COG0765	amino acid transport
Mame_05164	COG1126	abc transporter atp-binding protein
Mame_05166	COG0436	Aminotransferase
Mame_05169	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_05172	COG1028	Short-chain dehydrogenase reductase Sdr
Mame_05174	COG0154	amidase activity
Mame_05178	COG1175	transmembrane transport
Mame_05179	COG0395	ABC-type sugar transport system, permease component
Mame_05180	COG3842	ATPase activity
Mame_05183	COG2226	methyltransferase
Mame_05183	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Mame_05183	COG0596	Alpha beta hydrolase
Mame_05188	COG1175	transmembrane transport
Mame_05190	COG3842	ATPase activity
Mame_05191	COG0673	inositol 2-dehydrogenase activity
Mame_05194	COG3119	arylsulfatase activity
Mame_05200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mame_05202	COG0583	DNA-binding transcription factor activity
Mame_05205	COG0583	DNA-binding transcription factor activity
Mame_05207	COG0583	DNA-binding transcription factor activity
Mame_05208	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Mame_05209	COG3485	protocatechuate 3,4-dioxygenase
Mame_05212	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Mame_05215	COG2814	Major facilitator Superfamily
Mame_05216	COG2207	Transcriptional regulator
Mame_05221	COG1733	regulation of RNA biosynthetic process
Mame_05225	COG1609	Transcriptional regulator
Mame_05226	COG0363	glucosamine-6-phosphate deaminase activity
Mame_05227	COG4821	SIS domain
Mame_05231	COG1175	transmembrane transport
Mame_05232	COG0395	ABC-type sugar transport system, permease component
Mame_05234	COG3842	ATPase activity
Mame_05241	COG4948	Mandelate Racemase Muconate Lactonizing
Mame_05255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Mame_05256	COG0028	Belongs to the TPP enzyme family
Mame_05260	COG1609	Transcriptional regulator
Mame_05265	COG0395	ABC-type sugar transport system, permease component
Mame_05266	COG3842	ATPase activity
Mame_05269	COG3842	ATPase activity
Mame_05270	COG0395	ABC-type sugar transport system, permease component
Mame_05271	COG1175	transmembrane transport
Mame_05273	COG1609	Transcriptional regulator