locus-tag	class	description
AM586_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AM586_00040	COG0546	phosphoglycolate phosphatase activity
AM586_00070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM586_00075	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AM586_00085	COG1690	Belongs to the RtcB family
AM586_00095	COG0671	phosphoesterase, PA-phosphatase related
AM586_00100	COG0667	Aldo Keto reductase
AM586_00110	COG0302	gtp cyclohydrolase
AM586_00120	COG2816	NAD+ diphosphatase activity
AM586_00125	COG2192	nodulation
AM586_00150	COG0738	Major facilitator superfamily
AM586_00155	COG2723	6-phospho-beta-galactosidase activity
AM586_00160	COG2267	carboxylic ester hydrolase activity
AM586_00170	COG0629	single-stranded DNA binding
AM586_00190	COG1737	Transcriptional regulator
AM586_00200	COG1288	antiporter activity
AM586_00205	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AM586_00225	COG0753	catalase activity
AM586_00230	COG2974	May be involved in recombination
AM586_00235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM586_00240	COG1404	Belongs to the peptidase S8 family
AM586_00245	COG1404	Belongs to the peptidase S8 family
AM586_00250	COG4771	TonB-dependent receptor
AM586_00265	COG3706	GGDEF domain
AM586_00265	COG0745	RESPONSE REGULATOR receiver
AM586_00270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM586_00280	COG1032	radical SAM domain protein
AM586_00290	COG4628	conserved protein (DUF2132)
AM586_00295	COG0339	signal peptide processing
AM586_00300	COG0339	signal peptide processing
AM586_00330	COG2900	Belongs to the SlyX family
AM586_00340	COG0210	DNA helicase
AM586_00360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AM586_00365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AM586_00375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AM586_00395	COG0179	Fumarylacetoacetate (FAA) hydrolase
AM586_00400	COG0805	protein transport
AM586_00405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AM586_00410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AM586_00420	COG0140	phosphoribosyl-ATP diphosphatase activity
AM586_00425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AM586_00430	COG0107	imidazoleglycerol-phosphate synthase activity
AM586_00435	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AM586_00445	COG0131	Imidazoleglycerol-phosphate dehydratase
AM586_00465	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AM586_00470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AM586_00475	COG0271	Belongs to the BolA IbaG family
AM586_00480	COG0842	Transport permease protein
AM586_00485	COG1131	(ABC) transporter
AM586_00510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AM586_00515	COG1127	ABC transporter
AM586_00525	COG2843	Capsule synthesis protein
AM586_00535	COG0069	glutamate synthase activity
AM586_00535	COG0067	glutamate synthase
AM586_00535	COG0070	glutamate synthase
AM586_00555	COG0745	RESPONSE REGULATOR receiver
AM586_00560	COG2205	protein histidine kinase activity
AM586_00565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AM586_00570	COG2183	response to ionizing radiation
AM586_00575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AM586_00590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM586_00595	COG0789	Transcriptional regulator
AM586_00600	COG1960	acyl-CoA dehydrogenase activity
AM586_00605	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AM586_00610	COG0183	Belongs to the thiolase family
AM586_00620	COG1960	acyl-CoA dehydrogenase activity
AM586_00630	COG0604	alcohol dehydrogenase
AM586_00655	COG1619	proteins homologs of microcin C7 resistance protein MccF
AM586_00675	COG4191	Histidine kinase
AM586_00680	COG1960	acyl-CoA dehydrogenase activity
AM586_00690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM586_00700	COG2715	membrane protein required for spore maturation
AM586_00720	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AM586_00730	COG3023	N-Acetylmuramoyl-L-alanine amidase
AM586_00740	COG1649	PFAM Uncharacterised BCR, COG1649
AM586_00755	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AM586_00775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AM586_00790	COG0156	8-amino-7-oxononanoate synthase activity
AM586_00795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AM586_00800	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AM586_00810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM586_00830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AM586_00840	COG0792	nuclease activity
AM586_00845	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AM586_00875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AM586_00880	COG0321	lipoyl(octanoyl) transferase activity
AM586_00885	COG2921	Belongs to the UPF0250 family
AM586_00895	COG1280	lysine exporter protein (LysE YggA)
AM586_00900	COG0776	regulation of translation
AM586_00910	COG2354	Protein conserved in bacteria
AM586_00925	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AM586_00940	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AM586_00950	COG1279	arginine transmembrane transporter activity
AM586_01010	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AM586_01030	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_01050	COG1073	alpha beta
AM586_01060	COG1902	pentaerythritol trinitrate reductase activity
AM586_01075	COG2146	nitrite reductase [NAD(P)H] activity
AM586_01075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AM586_01085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM586_01090	COG1522	sequence-specific DNA binding
AM586_01095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AM586_01105	COG0742	ribosomal rna small subunit methyltransferase
AM586_01110	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AM586_01115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM586_01120	COG0840	transmembrane signaling receptor activity
AM586_01145	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM586_01145	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM586_01145	COG0506	proline dehydrogenase activity
AM586_01150	COG0686	Belongs to the AlaDH PNT family
AM586_01155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AM586_01160	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AM586_01165	COG0411	ABC transporter
AM586_01180	COG0559	Belongs to the binding-protein-dependent transport system permease family
AM586_01185	COG4214	carbohydrate transport
AM586_01190	COG0596	Alpha beta hydrolase
AM586_01195	COG1454	alcohol dehydrogenase
AM586_01205	COG0445	tRNA wobble uridine modification
AM586_01210	COG0357	Ribosomal RNA small subunit methyltransferase G
AM586_01215	COG1192	Involved in chromosome partitioning
AM586_01220	COG1475	DNA binding
AM586_01230	COG0356	it plays a direct role in the translocation of protons across the membrane
AM586_01240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AM586_01245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AM586_01250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AM586_01255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AM586_01260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AM586_01265	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AM586_01270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AM586_01280	COG1832	CoA-binding protein
AM586_01285	COG2326	polyphosphate kinase activity
AM586_01295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AM586_01295	COG0512	Glutamine amidotransferase of anthranilate synthase
AM586_01300	COG1309	transcriptional regulator
AM586_01320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AM586_01345	COG2070	2-Nitropropane dioxygenase
AM586_01410	COG2801	Transposase and inactivated derivatives
AM586_01415	COG1943	Transposase
AM586_01420	COG0488	(ABC) transporter
AM586_01430	COG3158	transport of potassium into the cell
AM586_01450	COG0577	efflux transmembrane transporter activity
AM586_01450	COG1136	(ABC) transporter
AM586_01460	COG2204	response regulator
AM586_01465	COG4191	Histidine kinase
AM586_01470	COG0477	Major facilitator Superfamily
AM586_01475	COG2153	protein acetylation
AM586_01485	COG2918	glutathione biosynthetic process
AM586_01495	COG2890	protein-(glutamine-N5) methyltransferase activity
AM586_01500	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AM586_01505	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AM586_01510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AM586_01515	COG0745	RESPONSE REGULATOR receiver
AM586_01525	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AM586_01530	COG2894	cell division
AM586_01535	COG0850	regulation of cytokinetic process
AM586_01540	COG0183	Belongs to the thiolase family
AM586_01545	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_01575	COG1902	pentaerythritol trinitrate reductase activity
AM586_01575	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM586_01595	COG0793	Belongs to the peptidase S41A family
AM586_01600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM586_01600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AM586_01615	COG3590	peptidase
AM586_01620	COG3590	peptidase
AM586_01635	COG3245	cytochrome
AM586_01655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM586_01660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AM586_01665	COG3290	protein histidine kinase activity
AM586_01670	COG2204	response regulator
AM586_01740	COG0438	transferase activity, transferring glycosyl groups
AM586_01750	COG0367	asparagine synthase
AM586_01755	COG0438	transferase activity, transferring glycosyl groups
AM586_01780	COG3409	Peptidoglycan-binding domain 1 protein
AM586_01780	COG3267	Type II secretory pathway component ExeA
AM586_01790	COG0489	protein tyrosine kinase activity
AM586_01865	COG1703	isobutyryl-CoA mutase activity
AM586_01865	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AM586_01865	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AM586_01885	COG3706	GGDEF domain
AM586_01910	COG4964	Belongs to the GSP D family
AM586_01945	COG2823	Periplasmic or secreted lipoprotein
AM586_01965	COG2969	positive regulation of protein catabolic process
AM586_01970	COG0625	glutathione transferase activity
AM586_01975	COG2857	Cytochrome c1
AM586_01980	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AM586_01985	COG0723	plastoquinol--plastocyanin reductase activity
AM586_01990	COG1970	mechanosensitive ion channel activity
AM586_02020	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AM586_02035	COG0588	phosphoglycerate mutase activity
AM586_02045	COG0793	Belongs to the peptidase S41A family
AM586_02050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AM586_02125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AM586_02130	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AM586_02140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AM586_02145	COG0523	cobalamin synthesis protein
AM586_02150	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AM586_02160	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM586_02165	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM586_02175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AM586_02180	COG1560	Kdo2-lipid A biosynthetic process
AM586_02190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AM586_02195	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AM586_02200	COG1950	PFAM Membrane protein of
AM586_02205	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AM586_02210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AM586_02215	COG0741	lytic transglycosylase activity
AM586_02230	COG0617	tRNA 3'-terminal CCA addition
AM586_02240	COG1522	sequence-specific DNA binding
AM586_02280	COG4206	TonB-dependent receptor
AM586_02285	COG1335	isochorismatase
AM586_02305	COG0037	tRNA processing
AM586_02315	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_02325	COG0484	heat shock protein binding
AM586_02330	COG0745	RESPONSE REGULATOR receiver
AM586_02360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AM586_02380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AM586_02385	COG0081	regulation of translation
AM586_02390	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AM586_02400	COG0085	RNA polymerase activity
AM586_02405	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AM586_02410	COG1335	isochorismatase
AM586_02455	COG2197	response regulator
AM586_02465	COG3851	Histidine kinase
AM586_02485	COG0525	valine-tRNA ligase activity
AM586_02495	COG1522	sequence-specific DNA binding
AM586_02540	COG0312	modulator of DNA gyrase
AM586_02560	COG0714	Associated with various cellular activities
AM586_02585	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AM586_02590	COG0583	DNA-binding transcription factor activity
AM586_02605	COG3852	Histidine kinase
AM586_02610	COG2204	response regulator
AM586_02615	COG0577	efflux transmembrane transporter activity
AM586_02620	COG0577	efflux transmembrane transporter activity
AM586_02625	COG1136	(ABC) transporter
AM586_02640	COG2194	sulfuric ester hydrolase activity
AM586_02645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AM586_02650	COG0049	tRNA binding
AM586_02655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AM586_02660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AM586_02665	COG0051	transcription antitermination factor activity, RNA binding
AM586_02675	COG1609	Transcriptional regulator
AM586_02680	COG0668	transmembrane transport
AM586_02695	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AM586_02700	COG0088	Forms part of the polypeptide exit tunnel
AM586_02705	COG0089	rRNA binding
AM586_02710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AM586_02715	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AM586_02720	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AM586_02725	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AM586_02730	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AM586_02735	COG0255	Belongs to the universal ribosomal protein uL29 family
AM586_02745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AM586_02750	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AM586_02755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AM586_02760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AM586_02765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AM586_02770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AM586_02775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AM586_02780	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AM586_02785	COG1841	ribosomal large subunit assembly
AM586_02790	COG0200	Binds to the 23S rRNA
AM586_02795	COG0201	protein transport
AM586_02800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AM586_02805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AM586_02810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AM586_02815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AM586_02820	COG0202	RNA polymerase activity
AM586_02825	COG0203	ribosomal protein L17
AM586_02830	COG4232	protein-disulfide reductase activity
AM586_02840	COG0745	RESPONSE REGULATOR receiver
AM586_02870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AM586_02875	COG2863	cytochrome
AM586_02885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AM586_02890	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AM586_02895	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AM586_02930	COG1965	Belongs to the frataxin family
AM586_02935	COG2205	protein histidine kinase activity
AM586_02935	COG2198	Histidine kinase
AM586_02935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM586_02935	COG0784	Response regulator, receiver
AM586_02940	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AM586_02985	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AM586_02990	COG1194	a g-specific adenine glycosylase
AM586_03000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AM586_03010	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AM586_03015	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AM586_03025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AM586_03030	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AM586_03035	COG0193	aminoacyl-tRNA hydrolase activity
AM586_03060	COG0012	GTP binding
AM586_03090	COG0179	Fumarylacetoacetate (FAA) hydrolase
AM586_03095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM586_03105	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AM586_03110	COG1085	galactose-1-phosphate uridylyltransferase
AM586_03130	COG4771	TonB-dependent receptor
AM586_03140	COG2723	6-phospho-beta-galactosidase activity
AM586_03160	COG3250	beta-galactosidase activity
AM586_03185	COG1129	ABC transporter
AM586_03200	COG3347	Dehydrogenase
AM586_03200	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_03205	COG4952	isomerase
AM586_03230	COG2814	Major facilitator Superfamily
AM586_03260	COG4771	TonB-dependent receptor
AM586_03270	COG3507	Belongs to the glycosyl hydrolase 43 family
AM586_03290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM586_03310	COG0477	Major facilitator Superfamily
AM586_03325	COG1609	Transcriptional regulator
AM586_03360	COG0673	inositol 2-dehydrogenase activity
AM586_03385	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AM586_03410	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AM586_03430	COG3052	prosthetic group binding
AM586_03450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AM586_03455	COG2186	Transcriptional regulator
AM586_03470	COG0352	thiamine-phosphate diphosphorylase activity
AM586_03475	COG0352	thiamine-phosphate diphosphorylase activity
AM586_03475	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AM586_03475	COG0351	phosphomethylpyrimidine kinase
AM586_03480	COG2022	thiamine diphosphate biosynthetic process
AM586_03490	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AM586_03505	COG3706	GGDEF domain
AM586_03505	COG0745	RESPONSE REGULATOR receiver
AM586_03520	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AM586_03535	COG1137	ATPase activity
AM586_03540	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AM586_03545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AM586_03550	COG1024	Enoyl-CoA hydratase
AM586_03555	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM586_03560	COG2610	gluconate transmembrane transporter activity
AM586_03565	COG1660	Displays ATPase and GTPase activities
AM586_03570	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AM586_03580	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AM586_03580	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AM586_03585	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM586_03590	COG1238	metal cluster binding
AM586_03595	COG0789	Transcriptional regulator
AM586_03600	COG1902	pentaerythritol trinitrate reductase activity
AM586_03600	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM586_03605	COG0247	lactate metabolic process
AM586_03625	COG1278	Cold shock
AM586_03630	COG2226	methyltransferase
AM586_03645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AM586_03670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AM586_03675	COG0494	nUDIX hydrolase
AM586_03680	COG3706	GGDEF domain
AM586_03685	COG3568	Endonuclease Exonuclease Phosphatase
AM586_03705	COG1960	acyl-CoA dehydrogenase activity
AM586_03710	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM586_03710	COG1024	Enoyl-CoA hydratase
AM586_03715	COG0183	Belongs to the thiolase family
AM586_03720	COG1024	Enoyl-CoA hydratase
AM586_03735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AM586_03740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AM586_03745	COG4206	TonB-dependent receptor
AM586_03750	COG0725	ABC transporter, periplasmic molybdate-binding protein
AM586_03755	COG4149	molybdate abc transporter
AM586_03760	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AM586_03780	COG1136	(ABC) transporter
AM586_03780	COG0577	efflux transmembrane transporter activity
AM586_03785	COG1136	(ABC) transporter
AM586_03785	COG0577	efflux transmembrane transporter activity
AM586_03810	COG0596	Alpha beta hydrolase
AM586_03860	COG0519	Catalyzes the synthesis of GMP from XMP
AM586_03865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM586_03865	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AM586_03940	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AM586_03965	COG4191	Histidine kinase
AM586_03965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM586_03975	COG3437	response regulator, receiver
AM586_03975	COG0784	Response regulator, receiver
AM586_04035	COG3108	Peptidase M15
AM586_04045	COG0612	Peptidase, M16
AM586_04070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM586_04075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AM586_04090	COG0427	acetyl-CoA hydrolase
AM586_04095	COG3781	membrane
AM586_04100	COG4294	response to UV
AM586_04115	COG0840	transmembrane signaling receptor activity
AM586_04135	COG3122	Protein conserved in bacteria
AM586_04140	COG3040	lipid binding
AM586_04175	COG1609	Transcriptional regulator
AM586_04190	COG3537	Alpha-1,2-mannosidase
AM586_04210	COG3493	citrate carrier protein
AM586_04250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM586_04250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AM586_04255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM586_04265	COG1607	acyl-coa hydrolase
AM586_04290	COG0753	catalase activity
AM586_04295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AM586_04300	COG1764	response to oxidative stress
AM586_04310	COG3590	peptidase
AM586_04335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM586_04350	COG4175	Glycine betaine
AM586_04355	COG4176	ABC-type proline glycine betaine transport system permease component
AM586_04360	COG2113	Glycine betaine
AM586_04365	COG2824	Alkylphosphonate utilization operon protein PhnA
AM586_04375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM586_04380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM586_04410	COG0134	indole-3-glycerol-phosphate synthase activity
AM586_04420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AM586_04435	COG0546	phosphoglycolate phosphatase activity
AM586_04440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AM586_04445	COG2967	ApaG domain
AM586_04500	COG1492	cobalamin metabolic process
AM586_04505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AM586_04515	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AM586_04525	COG1797	cobyrinic acid a,c-diamide synthase activity
AM586_04535	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AM586_04540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM586_04545	COG4206	TonB-dependent receptor
AM586_04555	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AM586_04560	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AM586_04635	COG4772	TonB-dependent receptor
AM586_04640	COG1012	belongs to the aldehyde dehydrogenase family
AM586_04650	COG3284	Transcriptional regulator
AM586_04695	COG1131	(ABC) transporter
AM586_04725	COG0347	Belongs to the P(II) protein family
AM586_04730	COG0004	ammonium transporteR
AM586_04745	COG0189	ligase activity
AM586_04760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM586_04765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM586_04770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM586_04770	COG2813	Specifically methylates the guanine in position
AM586_04775	COG0501	Belongs to the peptidase M48B family
AM586_04780	COG0564	pseudouridine synthase activity
AM586_04785	COG0708	Exodeoxyribonuclease III
AM586_04790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AM586_04795	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM586_04800	COG0154	amidase activity
AM586_04805	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM586_04810	COG1077	Cell shape determining protein MreB Mrl
AM586_04815	COG1792	Involved in formation and maintenance of cell shape
AM586_04825	COG0768	penicillin binding
AM586_04830	COG0772	Belongs to the SEDS family
AM586_04835	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AM586_04845	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AM586_04855	COG4221	oxidoreductase activity
AM586_04865	COG0018	arginyl-trna synthetase
AM586_04870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AM586_04870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AM586_04880	COG5000	phosphorelay sensor kinase activity
AM586_04885	COG2204	response regulator
AM586_04900	COG0121	glutamine amidotransferase
AM586_04905	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AM586_04910	COG1131	(ABC) transporter
AM586_04920	COG2801	Transposase and inactivated derivatives
AM586_04940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AM586_04945	COG0242	peptide deformylase activity
AM586_04955	COG0758	DNA mediated transformation
AM586_04960	COG2922	Belongs to the Smg family
AM586_04965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AM586_04965	COG0551	DNA topoisomerase type I activity
AM586_04985	COG1131	(ABC) transporter
AM586_04995	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AM586_05000	COG1765	OsmC-like protein
AM586_05010	COG4555	ABC transporter
AM586_05020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AM586_05025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AM586_05030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AM586_05040	COG0316	Belongs to the HesB IscA family
AM586_05045	COG0778	Nitroreductase
AM586_05050	COG0583	DNA-binding transcription factor activity
AM586_05055	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AM586_05060	COG4942	peptidase
AM586_05070	COG1490	D-aminoacyl-tRNA deacylase activity
AM586_05075	COG1881	PFAM PEBP family protein
AM586_05080	COG0406	alpha-ribazole phosphatase activity
AM586_05090	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AM586_05095	COG0138	bifunctional purine biosynthesis protein purh
AM586_05100	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AM586_05105	COG0632	four-way junction helicase activity
AM586_05110	COG2255	four-way junction helicase activity
AM586_05135	COG1228	amidohydrolase
AM586_05140	COG4585	Histidine kinase
AM586_05145	COG2197	response regulator
AM586_05155	COG0525	valine-tRNA ligase activity
AM586_05165	COG0745	RESPONSE REGULATOR receiver
AM586_05175	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AM586_05185	COG3590	peptidase
AM586_05200	COG0210	DNA helicase
AM586_05210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AM586_05220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AM586_05220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AM586_05235	COG0412	Dienelactone hydrolase
AM586_05260	COG1722	exodeoxyribonuclease VII activity
AM586_05265	COG0142	geranyltranstransferase activity
AM586_05285	COG0179	Fumarylacetoacetate (FAA) hydrolase
AM586_05320	COG2096	Adenosyltransferase
AM586_05325	COG0277	FAD linked oxidase domain protein
AM586_05330	COG0277	FAD linked oxidase domain protein
AM586_05335	COG0247	lactate metabolic process
AM586_05355	COG1082	Xylose isomerase domain protein TIM barrel
AM586_05365	COG0386	Belongs to the glutathione peroxidase family
AM586_05370	COG0247	lactate metabolic process
AM586_05375	COG0277	FAD linked oxidase domain protein
AM586_05380	COG0277	FAD linked oxidase domain protein
AM586_05385	COG1620	l-lactate permease
AM586_05390	COG2186	Transcriptional regulator
AM586_05430	COG4575	ribosome binding
AM586_05435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AM586_05455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AM586_05475	COG1040	competence protein
AM586_05480	COG2226	methyltransferase
AM586_05495	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AM586_05525	COG1612	heme a metabolic process
AM586_05530	COG0109	protoheme IX farnesyltransferase activity
AM586_05535	COG1999	signal sequence binding
AM586_05540	COG0628	permease
AM586_05550	COG1253	flavin adenine dinucleotide binding
AM586_05555	COG0583	DNA-binding transcription factor activity
AM586_05590	COG1366	Belongs to the anti-sigma-factor antagonist family
AM586_05595	COG0745	RESPONSE REGULATOR receiver
AM586_05595	COG3706	GGDEF domain
AM586_05600	COG0405	Gamma-glutamyltransferase
AM586_05650	COG0583	DNA-binding transcription factor activity
AM586_05655	COG1285	pathogenesis
AM586_05665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM586_05670	COG2177	Part of the ABC transporter FtsEX involved in
AM586_05675	COG2884	Cell division ATP-binding protein ftsE
AM586_05695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AM586_05715	COG2271	Major facilitator Superfamily
AM586_05730	COG2001	Belongs to the MraZ family
AM586_05735	COG0275	rRNA processing
AM586_05740	COG3116	cell division
AM586_05750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AM586_05755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AM586_05760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM586_05765	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AM586_05775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AM586_05780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM586_05785	COG1181	Belongs to the D-alanine--D-alanine ligase family
AM586_05790	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AM586_05800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AM586_05805	COG0678	peroxiredoxin activity
AM586_05805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM586_05830	COG0653	protein targeting
AM586_05835	COG2801	Transposase and inactivated derivatives
AM586_05845	COG0789	Transcriptional regulator
AM586_05855	COG0628	permease
AM586_05875	COG0667	Aldo Keto reductase
AM586_05885	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AM586_05890	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AM586_05900	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AM586_05930	COG4536	flavin adenine dinucleotide binding
AM586_05945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM586_05955	COG0402	S-adenosylhomocysteine deaminase activity
AM586_05960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AM586_05970	COG0737	Belongs to the 5'-nucleotidase family
AM586_05970	COG4085	toxin activity
AM586_05970	COG1525	nuclease
AM586_06035	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AM586_06050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM586_06050	COG0785	Cytochrome C biogenesis protein
AM586_06060	COG1846	Transcriptional regulator
AM586_06065	COG0583	DNA-binding transcription factor activity
AM586_06075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM586_06080	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AM586_06085	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AM586_06090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AM586_06095	COG1012	belongs to the aldehyde dehydrogenase family
AM586_06125	COG3279	Response regulator of the LytR AlgR family
AM586_06130	COG3275	phosphorelay sensor kinase activity
AM586_06155	COG0625	glutathione transferase activity
AM586_06175	COG1309	transcriptional regulator
AM586_06180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM586_06195	COG0493	'glutamate synthase
AM586_06205	COG1953	Uracil, thiamine, allantoin
AM586_06255	COG0004	ammonium transporteR
AM586_06260	COG0583	DNA-binding transcription factor activity
AM586_06295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM586_06295	COG1116	anion transmembrane transporter activity
AM586_06305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM586_06315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM586_06320	COG0243	molybdopterin cofactor binding
AM586_06330	COG0583	DNA-binding transcription factor activity
AM586_06335	COG2814	Major facilitator Superfamily
AM586_06340	COG0625	glutathione transferase activity
AM586_06350	COG4106	trans-aconitate 2-methyltransferase activity
AM586_06360	COG0861	Integral membrane protein TerC family
AM586_06380	COG0142	geranyltranstransferase activity
AM586_06385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AM586_06390	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AM586_06395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AM586_06405	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AM586_06420	COG0811	peptide transport
AM586_06445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AM586_06450	COG2878	Part of a membrane complex involved in electron transport
AM586_06470	COG0492	ferredoxin-NADP+ reductase activity
AM586_06475	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AM586_06520	COG1546	Belongs to the CinA family
AM586_06520	COG1058	Belongs to the CinA family
AM586_06550	COG3852	Histidine kinase
AM586_06560	COG0598	Magnesium transport protein CorA
AM586_06580	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AM586_06595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AM586_06605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AM586_06610	COG0024	Methionine aminopeptidase
AM586_06615	COG4206	TonB-dependent receptor
AM586_06620	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AM586_06630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM586_06635	COG0312	modulator of DNA gyrase
AM586_06645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM586_06650	COG4771	TonB-dependent receptor
AM586_06660	COG4771	TonB-dependent receptor
AM586_06685	COG0837	glucose binding
AM586_06685	COG1737	Transcriptional regulator
AM586_06690	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AM586_06700	COG0779	Required for maturation of 30S ribosomal subunits
AM586_06710	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AM586_06715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AM586_06720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AM586_06805	COG1706	bacterial-type flagellum-dependent cell motility
AM586_06810	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AM586_06815	COG4786	Flagellar basal body rod
AM586_06825	COG1749	Flagellar hook protein flgE
AM586_06830	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AM586_06835	COG1558	bacterial-type flagellum-dependent cell motility
AM586_06840	COG1815	bacterial-type flagellum-dependent cell motility
AM586_06870	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AM586_06875	COG1191	sigma factor activity
AM586_06900	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AM586_06920	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AM586_06930	COG1677	Flagellar hook-basal body complex protein FliE
AM586_06940	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AM586_06955	COG1684	flagellar biosynthetic protein fliR
AM586_06975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AM586_06990	COG0840	transmembrane signaling receptor activity
AM586_07040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM586_07050	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_07065	COG0583	DNA-binding transcription factor activity
AM586_07070	COG2271	Major facilitator Superfamily
AM586_07075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AM586_07080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AM586_07085	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM586_07090	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_07115	COG1764	response to oxidative stress
AM586_07135	COG0583	DNA-binding transcription factor activity
AM586_07160	COG0431	NADPH-dependent FMN reductase
AM586_07170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AM586_07195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM586_07195	COG2205	protein histidine kinase activity
AM586_07205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM586_07210	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AM586_07215	COG2080	2 iron, 2 sulfur cluster binding
AM586_07230	COG4251	negative regulation of phosphorylation
AM586_07230	COG5001	Diguanylate cyclase
AM586_07230	COG2203	Gaf domain
AM586_07230	COG3706	GGDEF domain
AM586_07235	COG1846	Transcriptional regulator
AM586_07255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM586_07265	COG3300	MHYT domain
AM586_07265	COG5001	Diguanylate cyclase
AM586_07280	COG0840	transmembrane signaling receptor activity
AM586_07290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AM586_07295	COG1566	PFAM secretion protein HlyD family protein
AM586_07320	COG0583	DNA-binding transcription factor activity
AM586_07325	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AM586_07330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AM586_07335	COG0243	molybdopterin cofactor binding
AM586_07340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM586_07375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AM586_07380	COG1085	galactose-1-phosphate uridylyltransferase
AM586_07390	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AM586_07395	COG3250	beta-galactosidase activity
AM586_07425	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_07440	COG1704	LemA family
AM586_07445	COG0284	orotidine-5'-phosphate decarboxylase activity
AM586_07450	COG2925	Exonuclease
AM586_07455	COG3706	GGDEF domain
AM586_07455	COG0745	RESPONSE REGULATOR receiver
AM586_07490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM586_07515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AM586_07540	COG2814	Major facilitator Superfamily
AM586_07560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AM586_07585	COG0531	amino acid
AM586_07675	COG0584	glycerophosphoryl diester phosphodiesterase
AM586_07685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AM586_07690	COG0425	Belongs to the sulfur carrier protein TusA family
AM586_07695	COG2086	electron transfer activity
AM586_07705	COG1960	acyl-CoA dehydrogenase activity
AM586_07720	COG0228	four-way junction DNA binding
AM586_07725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AM586_07730	COG0336	Belongs to the RNA methyltransferase TrmD family
AM586_07735	COG0335	large ribosomal subunit rRNA binding
AM586_07745	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AM586_07760	COG0612	Peptidase, M16
AM586_07765	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_07770	COG2188	Transcriptional regulator
AM586_07785	COG1472	Belongs to the glycosyl hydrolase 3 family
AM586_07790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM586_07795	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AM586_07800	COG2971	BadF BadG BcrA BcrD
AM586_07805	COG0628	permease
AM586_07810	COG0501	Belongs to the peptidase M48B family
AM586_07855	COG3409	Peptidoglycan-binding domain 1 protein
AM586_07855	COG3267	Type II secretory pathway component ExeA
AM586_07865	COG1763	Mo-molybdopterin cofactor biosynthetic process
AM586_07880	COG3220	belongs to the UPF0276 family
AM586_07895	COG0114	fumarate hydratase activity
AM586_07905	COG1733	regulation of RNA biosynthetic process
AM586_07910	COG2076	Multidrug Resistance protein
AM586_07930	COG3590	peptidase
AM586_08005	COG1914	H( )-stimulated, divalent metal cation uptake system
AM586_08010	COG0693	protein deglycase activity
AM586_08015	COG0693	protein deglycase activity
AM586_08050	COG3550	peptidyl-serine autophosphorylation
AM586_08060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AM586_08070	COG5002	protein histidine kinase activity
AM586_08080	COG3436	PFAM IS66 Orf2 family protein
AM586_08085	COG4372	Transposase
AM586_08100	COG5001	Diguanylate cyclase
AM586_08100	COG3300	MHYT domain
AM586_08110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM586_08110	COG1017	nitric oxide dioxygenase activity
AM586_08115	COG1959	2 iron, 2 sulfur cluster binding
AM586_08130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM586_08130	COG2205	protein histidine kinase activity
AM586_08135	COG0745	RESPONSE REGULATOR receiver
AM586_08135	COG3706	GGDEF domain
AM586_08150	COG1970	mechanosensitive ion channel activity
AM586_08160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AM586_08170	COG2010	Cytochrome c
AM586_08170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM586_08210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AM586_08235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM586_08250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM586_08270	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AM586_08285	COG0287	Prephenate dehydrogenase
AM586_08290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AM586_08295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AM586_08305	COG0776	regulation of translation
AM586_08315	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AM586_08325	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AM586_08345	COG2951	lytic endotransglycosylase activity
AM586_08360	COG0714	Associated with various cellular activities
AM586_08365	COG0123	including yeast histone deacetylase and acetoin utilization protein
AM586_08390	COG3384	dioxygenase
AM586_08425	COG2205	protein histidine kinase activity
AM586_08440	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_08445	COG0745	RESPONSE REGULATOR receiver
AM586_08455	COG0251	oxidation-reduction process
AM586_08480	COG1570	exodeoxyribonuclease VII activity
AM586_08485	COG0811	peptide transport
AM586_08490	COG0848	biopolymer transport protein
AM586_08495	COG1663	tetraacyldisaccharide 4'-kinase activity
AM586_08500	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AM586_08505	COG0563	adenylate kinase activity
AM586_08520	COG0427	acetyl-CoA hydrolase
AM586_08535	COG0405	Gamma-glutamyltransferase
AM586_08545	COG0745	RESPONSE REGULATOR receiver
AM586_08550	COG4191	Histidine kinase
AM586_08550	COG0784	Response regulator, receiver
AM586_08585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AM586_08590	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AM586_08595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM586_08670	COG0438	transferase activity, transferring glycosyl groups
AM586_08685	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AM586_08690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AM586_08695	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AM586_08730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AM586_08740	COG2116	formate transmembrane transporter activity
AM586_08745	COG0745	RESPONSE REGULATOR receiver
AM586_08770	COG1404	Belongs to the peptidase S8 family
AM586_08815	COG1450	Type ii and iii secretion system protein
AM586_08835	COG0728	peptidoglycan biosynthetic process
AM586_08840	COG0268	Binds directly to 16S ribosomal RNA
AM586_08850	COG1187	pseudouridine synthase activity
AM586_08860	COG1278	Cold shock
AM586_08865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AM586_08870	COG0542	response to heat
AM586_08880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM586_08900	COG2130	NADP-dependent
AM586_08905	COG1309	transcriptional regulator
AM586_08910	COG0840	transmembrane signaling receptor activity
AM586_08915	COG0626	cystathionine gamma-synthase activity
AM586_08930	COG3162	membrane
AM586_08935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM586_08940	COG2234	aminopeptidase activity
AM586_08960	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AM586_08975	COG0708	Exodeoxyribonuclease III
AM586_08995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AM586_09005	COG0795	lipopolysaccharide-transporting ATPase activity
AM586_09020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AM586_09020	COG1648	precorrin-2 dehydrogenase activity
AM586_09025	COG2895	sulfate adenylyltransferase (ATP) activity
AM586_09035	COG0175	sulfate reduction
AM586_09045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM586_09050	COG0583	DNA-binding transcription factor activity
AM586_09075	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM586_09090	COG2972	Histidine kinase
AM586_09105	COG2070	2-Nitropropane dioxygenase
AM586_09110	COG1666	GTP binding
AM586_09115	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AM586_09120	COG0572	uridine kinase
AM586_09125	COG2203	Gaf domain
AM586_09125	COG3706	GGDEF domain
AM586_09125	COG5001	Diguanylate cyclase
AM586_09125	COG4251	negative regulation of phosphorylation
AM586_09130	COG2201	protein-glutamate methylesterase activity
AM586_09150	COG0835	chemotaxis
AM586_09160	COG0137	argininosuccinate synthase activity
AM586_09165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AM586_09170	COG1162	GTPase activity
AM586_09175	COG2154	pterin-4-alpha-carbinolamine dehydratase
AM586_09180	COG0501	Belongs to the peptidase M48B family
AM586_09185	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AM586_09190	COG2205	protein histidine kinase activity
AM586_09210	COG0516	GMP reductase activity
AM586_09210	COG0517	IMP dehydrogenase activity
AM586_09230	COG3012	SEC-C Motif Domain Protein
AM586_09230	COG3318	Belongs to the UPF0149 family
AM586_09240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AM586_09275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM586_09295	COG0406	alpha-ribazole phosphatase activity
AM586_09295	COG0328	RNA-DNA hybrid ribonuclease activity
AM586_09320	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AM586_09330	COG0823	Involved in the tonB-independent uptake of proteins
AM586_09350	COG0824	Thioesterase
AM586_09355	COG4221	oxidoreductase activity
AM586_09360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AM586_09365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AM586_09395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM586_09395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM586_09405	COG0823	Involved in the tonB-independent uptake of proteins
AM586_09405	COG1506	peptidase
AM586_09410	COG0612	Peptidase, M16
AM586_09420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AM586_09425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AM586_09435	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AM586_09440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AM586_09445	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AM586_09455	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AM586_09460	COG0438	transferase activity, transferring glycosyl groups
AM586_09480	COG5002	protein histidine kinase activity
AM586_09480	COG2205	protein histidine kinase activity
AM586_09480	COG0784	Response regulator, receiver
AM586_09485	COG2879	small protein
AM586_09490	COG1966	Carbon starvation protein
AM586_09555	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_09560	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_09565	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AM586_09575	COG0671	phosphoesterase, PA-phosphatase related
AM586_09585	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AM586_09590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM586_09600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AM586_09615	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AM586_09615	COG2885	chlorophyll binding
AM586_09645	COG2982	Protein involved in outer membrane biogenesis
AM586_09700	COG0628	permease
AM586_09710	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AM586_09710	COG2885	chlorophyll binding
AM586_09720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM586_09720	COG0678	peroxiredoxin activity
AM586_09735	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_09740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AM586_09755	COG3622	Belongs to the hyi family
AM586_09770	COG0513	Belongs to the DEAD box helicase family
AM586_09790	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AM586_09795	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AM586_09805	COG1309	transcriptional regulator
AM586_09815	COG0745	RESPONSE REGULATOR receiver
AM586_09815	COG3706	GGDEF domain
AM586_09855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AM586_09860	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AM586_09865	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM586_09870	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AM586_09885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AM586_09890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AM586_09910	COG1538	Outer membrane efflux protein
AM586_09920	COG2271	Major facilitator Superfamily
AM586_09925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AM586_09955	COG4191	Histidine kinase
AM586_09960	COG4566	intracellular signal transduction
AM586_09970	COG2130	NADP-dependent
AM586_09975	COG0788	formyltetrahydrofolate deformylase activity
AM586_09980	COG4681	YaeQ
AM586_10005	COG2010	Cytochrome c
AM586_10005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM586_10055	COG0181	hydroxymethylbilane synthase activity
AM586_10065	COG2959	enzyme of heme biosynthesis
AM586_10075	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AM586_10095	COG0559	Belongs to the binding-protein-dependent transport system permease family
AM586_10105	COG0410	ABC transporter
AM586_10110	COG0411	ABC transporter
AM586_10150	COG0437	4 iron, 4 sulfur cluster binding
AM586_10190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AM586_10210	COG1304	FMN binding
AM586_10230	COG0028	Belongs to the TPP enzyme family
AM586_10235	COG0300	oxidoreductase activity
AM586_10255	COG2204	response regulator
AM586_10260	COG2860	membrane
AM586_10275	COG0492	ferredoxin-NADP+ reductase activity
AM586_10280	COG1674	ftsk spoiiie
AM586_10285	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AM586_10320	COG1002	Type II restriction enzyme, methylase subunits
AM586_10325	COG1061	Type III restriction enzyme res subunit
AM586_10330	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM586_10415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AM586_10440	COG0840	transmembrane signaling receptor activity
AM586_10445	COG2890	protein-(glutamine-N5) methyltransferase activity
AM586_10455	COG2321	neutral zinc metallopeptidase
AM586_10475	COG0741	lytic transglycosylase activity
AM586_10475	COG1196	nuclear chromosome segregation
AM586_10475	COG0739	heme binding
AM586_10480	COG1376	ErfK ybiS ycfS ynhG family protein
AM586_10525	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AM586_10535	COG3706	GGDEF domain
AM586_10560	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AM586_10565	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM586_10570	COG1295	ribonuclease BN
AM586_10580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AM586_10605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM586_10610	COG0513	Belongs to the DEAD box helicase family
AM586_10615	COG1388	LysM domain
AM586_10615	COG0741	lytic transglycosylase activity
AM586_10650	COG1214	PFAM Peptidase M22, glycoprotease
AM586_10660	COG1573	uracil-dna glycosylase
AM586_10670	COG0477	Major facilitator Superfamily
AM586_10675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AM586_10690	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM586_10695	COG0573	inorganic phosphate transmembrane transporter activity
AM586_10705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AM586_10710	COG0704	Plays a role in the regulation of phosphate uptake
AM586_10720	COG5002	protein histidine kinase activity
AM586_10725	COG1752	Esterase of the alpha-beta hydrolase superfamily
AM586_10730	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AM586_10735	COG0505	Belongs to the CarA family
AM586_10740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AM586_10745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM586_10760	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AM586_10765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM586_10775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM586_10790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AM586_10815	COG1596	polysaccharide export
AM586_10820	COG0489	protein tyrosine kinase activity
AM586_10820	COG3206	protein involved in exopolysaccharide biosynthesis
AM586_10850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AM586_10915	COG1086	Polysaccharide biosynthesis protein
AM586_10940	COG3275	phosphorelay sensor kinase activity
AM586_10945	COG3279	Response regulator of the LytR AlgR family
AM586_11065	COG0557	exoribonuclease II activity
AM586_11070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM586_11080	COG3132	Protein of unknown function, DUF480
AM586_11095	COG1131	(ABC) transporter
AM586_11105	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM586_11120	COG0215	cysteine-tRNA ligase activity
AM586_11130	COG0825	malonyl-CoA metabolic process
AM586_11135	COG0037	tRNA processing
AM586_11155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM586_11165	COG2207	Transcriptional regulator
AM586_11200	COG0583	DNA-binding transcription factor activity
AM586_11215	COG2207	Transcriptional regulator
AM586_11245	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_11250	COG3038	cytochrome b561
AM586_11280	COG0640	Transcriptional regulator
AM586_11285	COG0500	methyltransferase
AM586_11300	COG2988	succinylglutamate desuccinylase activity
AM586_11305	COG0251	oxidation-reduction process
AM586_11315	COG0583	DNA-binding transcription factor activity
AM586_11325	COG1012	belongs to the aldehyde dehydrogenase family
AM586_11350	COG4172	Belongs to the ABC transporter superfamily
AM586_11355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM586_11360	COG0601	transmembrane transport
AM586_11365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM586_11405	COG4533	DNA binding
AM586_11420	COG1027	Aspartate ammonia-lyase
AM586_11435	COG1522	sequence-specific DNA binding
AM586_11440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AM586_11445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM586_11470	COG2132	Multicopper oxidase
AM586_11510	COG2814	Major facilitator Superfamily
AM586_11515	COG0583	DNA-binding transcription factor activity
AM586_11530	COG0683	leucine binding
AM586_11535	COG1022	Amp-dependent synthetase and ligase
AM586_11535	COG3320	Male sterility
AM586_11540	COG1012	belongs to the aldehyde dehydrogenase family
AM586_11545	COG1024	Enoyl-CoA hydratase
AM586_11555	COG0683	leucine binding
AM586_11560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM586_11565	COG1414	Transcriptional regulator
AM586_11575	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM586_11580	COG0183	Belongs to the thiolase family
AM586_11590	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM586_11595	COG0411	ABC transporter
AM586_11625	COG2267	carboxylic ester hydrolase activity
AM586_11630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AM586_11635	COG3485	protocatechuate 3,4-dioxygenase
AM586_11640	COG3485	protocatechuate 3,4-dioxygenase
AM586_11645	COG1414	Transcriptional regulator
AM586_11665	COG2814	Major facilitator Superfamily
AM586_11670	COG2807	transmembrane transport
AM586_11675	COG1522	sequence-specific DNA binding
AM586_11695	COG0583	DNA-binding transcription factor activity
AM586_11710	COG0330	HflC and HflK could
AM586_11720	COG0840	transmembrane signaling receptor activity
AM586_11730	COG3275	phosphorelay sensor kinase activity
AM586_11735	COG1234	tRNA 3'-trailer cleavage
AM586_11745	COG2159	amidohydrolase
AM586_11755	COG0583	DNA-binding transcription factor activity
AM586_11765	COG3384	dioxygenase
AM586_11795	COG0248	Ppx GppA phosphatase
AM586_11810	COG0583	DNA-binding transcription factor activity
AM586_11830	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_11840	COG0583	DNA-binding transcription factor activity
AM586_11860	COG1741	Belongs to the pirin family
AM586_11870	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_11875	COG0625	glutathione transferase activity
AM586_11890	COG2217	Heavy metal translocating P-type atpase
AM586_11905	COG0697	spore germination
AM586_11910	COG0730	response to heat
AM586_11920	COG1042	CoA-binding domain protein
AM586_11920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM586_11920	COG0045	succinate-CoA ligase (ADP-forming) activity
AM586_11940	COG0583	DNA-binding transcription factor activity
AM586_11950	COG4566	intracellular signal transduction
AM586_11960	COG0477	Major facilitator Superfamily
AM586_11965	COG0513	Belongs to the DEAD box helicase family
AM586_11980	COG1252	NADH dehydrogenase
AM586_11985	COG4585	Histidine kinase
AM586_11995	COG5002	protein histidine kinase activity
AM586_12065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AM586_12075	COG3038	cytochrome b561
AM586_12080	COG0583	DNA-binding transcription factor activity
AM586_12090	COG1301	dicarboxylic acid transport
AM586_12100	COG0469	pyruvate kinase activity
AM586_12110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AM586_12120	COG2234	aminopeptidase activity
AM586_12140	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AM586_12145	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_12150	COG3706	GGDEF domain
AM586_12160	COG0829	nickel cation binding
AM586_12170	COG0832	Belongs to the urease beta subunit family
AM586_12175	COG0804	urea catabolic process
AM586_12180	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AM586_12185	COG0830	nickel cation binding
AM586_12190	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AM586_12215	COG0656	L-ascorbic acid biosynthetic process
AM586_12220	COG3300	MHYT domain
AM586_12220	COG5001	Diguanylate cyclase
AM586_12225	COG3706	GGDEF domain
AM586_12265	COG1902	pentaerythritol trinitrate reductase activity
AM586_12285	COG0463	Glycosyl transferase, family 2
AM586_12290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AM586_12300	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM586_12300	COG3952	Lipid A Biosynthesis
AM586_12325	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AM586_12335	COG0688	phosphatidylethanolamine metabolic process
AM586_12340	COG4771	TonB-dependent receptor
AM586_12360	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_12370	COG1024	Enoyl-CoA hydratase
AM586_12375	COG1960	acyl-CoA dehydrogenase activity
AM586_12385	COG0537	adenosine 5'-monophosphoramidase activity
AM586_12400	COG0024	Methionine aminopeptidase
AM586_12405	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM586_12430	COG1418	mRNA catabolic process
AM586_12480	COG0515	serine threonine protein kinase
AM586_12515	COG2815	serine threonine protein kinase
AM586_12515	COG0515	serine threonine protein kinase
AM586_12525	COG1408	metallophosphoesterase
AM586_12545	COG2135	peptidase activity
AM586_13125	COG1435	thymidine kinase activity
AM586_13135	COG0793	Belongs to the peptidase S41A family
AM586_13145	COG1960	acyl-CoA dehydrogenase activity
AM586_13150	COG1960	acyl-CoA dehydrogenase activity
AM586_13155	COG2030	dehydratase
AM586_13155	COG1012	belongs to the aldehyde dehydrogenase family
AM586_13160	COG5001	Diguanylate cyclase
AM586_13160	COG4251	negative regulation of phosphorylation
AM586_13160	COG3706	GGDEF domain
AM586_13160	COG2203	Gaf domain
AM586_13165	COG2205	protein histidine kinase activity
AM586_13165	COG5002	protein histidine kinase activity
AM586_13165	COG0784	Response regulator, receiver
AM586_13170	COG1960	acyl-CoA dehydrogenase activity
AM586_13185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AM586_13190	COG1459	type II secretion system
AM586_13250	COG1450	Type ii and iii secretion system protein
AM586_13255	COG3267	Type II secretory pathway component ExeA
AM586_13255	COG3409	Peptidoglycan-binding domain 1 protein
AM586_13265	COG0436	Aminotransferase
AM586_13275	COG3022	response to hydroperoxide
AM586_13285	COG0564	pseudouridine synthase activity
AM586_13300	COG3243	poly(R)-hydroxyalkanoic acid synthase
AM586_13305	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AM586_13310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AM586_13315	COG0626	cystathionine gamma-synthase activity
AM586_13330	COG2086	electron transfer activity
AM586_13340	COG0183	Belongs to the thiolase family
AM586_13345	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM586_13350	COG1024	Enoyl-CoA hydratase
AM586_13365	COG2814	Major facilitator Superfamily
AM586_13370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM586_13400	COG1929	Belongs to the glycerate kinase type-1 family
AM586_13405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM586_13420	COG1215	transferase activity, transferring glycosyl groups
AM586_13445	COG0411	ABC transporter
AM586_13465	COG0697	spore germination
AM586_13470	COG1522	sequence-specific DNA binding
AM586_13490	COG2130	NADP-dependent
AM586_13495	COG0560	Phosphoserine phosphatase
AM586_13500	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AM586_13525	COG1297	OPT oligopeptide transporter protein
AM586_13535	COG0583	DNA-binding transcription factor activity
AM586_13540	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AM586_13555	COG3104	oligopeptide transport
AM586_13560	COG1611	Belongs to the LOG family
AM586_13565	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AM586_13570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM586_13575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AM586_13580	COG0737	Belongs to the 5'-nucleotidase family
AM586_13615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AM586_13625	COG4591	ABC-type transport system involved in lipoprotein release permease component
AM586_13635	COG0084	hydrolase, TatD family'
AM586_13640	COG3501	Rhs element vgr protein
AM586_13660	COG2205	protein histidine kinase activity
AM586_13665	COG0745	RESPONSE REGULATOR receiver
AM586_13680	COG0717	Belongs to the dCTP deaminase family
AM586_13685	COG1982	Orn Lys Arg decarboxylase major
AM586_13705	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AM586_13720	COG1132	(ABC) transporter
AM586_13740	COG0277	FAD linked oxidase domain protein
AM586_13755	COG1295	ribonuclease BN
AM586_13790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AM586_13800	COG5001	Diguanylate cyclase
AM586_13800	COG3300	MHYT domain
AM586_13805	COG1960	acyl-CoA dehydrogenase activity
AM586_13810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AM586_13820	COG1278	Cold shock
AM586_13825	COG0583	DNA-binding transcription factor activity
AM586_13830	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AM586_13840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM586_13845	COG2226	methyltransferase
AM586_13850	COG0328	RNA-DNA hybrid ribonuclease activity
AM586_13875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AM586_13880	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
AM586_13895	COG0784	Response regulator, receiver
AM586_13895	COG4191	Histidine kinase
AM586_13910	COG0205	6-phosphofructokinase activity
AM586_13915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM586_13915	COG0574	Belongs to the PEP-utilizing enzyme family
AM586_13940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM586_13945	COG1129	ABC transporter
AM586_13945	COG0842	Transport permease protein
AM586_13950	COG0842	Transport permease protein
AM586_14000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AM586_14005	COG0596	Alpha beta hydrolase
AM586_14010	COG0385	Bile acid
AM586_14015	COG1309	transcriptional regulator
AM586_14025	COG4993	Dehydrogenase
AM586_14045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM586_14055	COG3243	poly(R)-hydroxyalkanoic acid synthase
AM586_14065	COG4771	TonB-dependent receptor
AM586_14075	COG0784	Response regulator, receiver
AM586_14075	COG4191	Histidine kinase
AM586_14090	COG0583	DNA-binding transcription factor activity
AM586_14095	COG3960	tartronate-semialdehyde synthase activity
AM586_14100	COG3622	Belongs to the hyi family
AM586_14105	COG2084	Dehydrogenase
AM586_14115	COG0469	pyruvate kinase activity
AM586_14120	COG0840	transmembrane signaling receptor activity
AM586_14125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AM586_14145	COG2351	hydroxyisourate hydrolase activity
AM586_14155	COG2233	PERMEase
AM586_14165	COG0477	Major facilitator Superfamily
AM586_14175	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AM586_14195	COG0628	permease
AM586_14200	COG0723	plastoquinol--plastocyanin reductase activity
AM586_14215	COG1408	metallophosphoesterase
AM586_14220	COG0531	amino acid
AM586_14230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AM586_14230	COG0189	ligase activity
AM586_14235	COG0189	ligase activity
AM586_14235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AM586_14265	COG0443	Heat shock 70 kDa protein
AM586_14270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM586_14280	COG1505	serine-type exopeptidase activity
AM586_14300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM586_14305	COG1760	l-serine dehydratase
AM586_14315	COG0303	'Molybdopterin
AM586_14320	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AM586_14325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AM586_14335	COG4206	TonB-dependent receptor
AM586_14340	COG1522	sequence-specific DNA binding
AM586_14375	COG1233	COG1233 Phytoene dehydrogenase and related
AM586_14380	COG1562	ergosterol biosynthetic process
AM586_14405	COG0544	peptidyl-prolyl cis-trans isomerase activity
AM586_14410	COG0740	serine-type endopeptidase activity
AM586_14415	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AM586_14420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AM586_14440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM586_14445	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AM586_14455	COG4181	ATPase activity
AM586_14460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AM586_14460	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AM586_14475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AM586_14475	COG0047	phosphoribosylformylglycinamidine synthase activity
AM586_14480	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM586_14485	COG0642	Histidine kinase
AM586_14490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM586_14495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM586_14505	COG2917	probably involved in intracellular septation
AM586_14510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AM586_14515	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AM586_14520	COG0318	PFAM AMP-dependent synthetase and ligase
AM586_14540	COG3739	integral membrane protein
AM586_14545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM586_14595	COG4221	oxidoreductase activity
AM586_14620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AM586_14625	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AM586_14640	COG1247	-acetyltransferase
AM586_14655	COG0084	hydrolase, TatD family'
AM586_14665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AM586_14725	COG0826	peptidase U32
AM586_14740	COG0243	molybdopterin cofactor binding
AM586_14775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM586_14780	COG1446	asparaginase
AM586_14790	COG0765	amino acid transport
AM586_14795	COG0765	amino acid transport
AM586_14800	COG3142	Participates in the control of copper homeostasis
AM586_14825	COG1902	pentaerythritol trinitrate reductase activity
AM586_14850	COG4221	oxidoreductase activity
AM586_14865	COG0318	PFAM AMP-dependent synthetase and ligase
AM586_14890	COG0071	Belongs to the small heat shock protein (HSP20) family
AM586_14940	COG1228	amidohydrolase
AM586_14955	COG0438	transferase activity, transferring glycosyl groups
AM586_14965	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AM586_14975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AM586_14995	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AM586_15000	COG0488	(ABC) transporter
AM586_15010	COG1619	proteins homologs of microcin C7 resistance protein MccF
AM586_15020	COG0590	tRNA wobble adenosine to inosine editing
AM586_15030	COG0602	queuosine metabolic process
AM586_15040	COG2203	Gaf domain
AM586_15040	COG4251	negative regulation of phosphorylation
AM586_15040	COG5001	Diguanylate cyclase
AM586_15040	COG3706	GGDEF domain
AM586_15045	COG3829	transcription factor binding
AM586_15045	COG3290	protein histidine kinase activity
AM586_15075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM586_15080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AM586_15085	COG0066	3-isopropylmalate dehydratase activity
AM586_15145	COG1051	belongs to the nudix hydrolase family
AM586_15155	COG0668	transmembrane transport
AM586_15180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM586_15185	COG4591	ABC-type transport system involved in lipoprotein release permease component
AM586_15200	COG2252	PERMEase
AM586_15220	COG0477	Major facilitator Superfamily
AM586_15225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM586_15230	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AM586_15240	COG0668	transmembrane transport
AM586_15245	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_15280	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AM586_15295	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AM586_15300	COG1845	cytochrome c oxidase, subunit III
AM586_15305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AM586_15310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AM586_15315	COG0477	Major facilitator Superfamily
AM586_15320	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AM586_15330	COG3546	catalase activity
AM586_15350	COG1346	cytolysis
AM586_15355	COG1380	Effector of murein hydrolase LrgA
AM586_15360	COG0840	transmembrane signaling receptor activity
AM586_15380	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AM586_15390	COG1253	flavin adenine dinucleotide binding
AM586_15400	COG0640	Transcriptional regulator
AM586_15420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM586_15430	COG1113	amino acid transport
AM586_15440	COG2203	Gaf domain
AM586_15440	COG3706	GGDEF domain
AM586_15440	COG4251	negative regulation of phosphorylation
AM586_15440	COG5001	Diguanylate cyclase
AM586_15445	COG2271	Major facilitator Superfamily
AM586_15490	COG0662	Cupin 2, conserved barrel domain protein
AM586_15500	COG1501	Belongs to the glycosyl hydrolase 31 family
AM586_15505	COG0708	Exodeoxyribonuclease III
AM586_15530	COG2267	carboxylic ester hydrolase activity
AM586_15535	COG0784	Response regulator, receiver
AM586_15535	COG4191	Histidine kinase
AM586_15540	COG3386	PFAM SMP-30 Gluconolaconase
AM586_15550	COG0022	dehydrogenase e1 component
AM586_15575	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM586_15580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM586_15580	COG0475	glutathione-regulated potassium exporter activity
AM586_15610	COG1609	Transcriptional regulator
AM586_15620	COG0395	ABC-type sugar transport system, permease component
AM586_15625	COG1175	transmembrane transport
AM586_15640	COG3507	Belongs to the glycosyl hydrolase 43 family
AM586_15655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM586_15660	COG1305	Transglutaminase-like
AM586_15715	COG1971	Probably functions as a manganese efflux pump
AM586_15725	COG0837	glucose binding
AM586_15725	COG1737	Transcriptional regulator
AM586_15730	COG1472	Belongs to the glycosyl hydrolase 3 family
AM586_15735	COG2723	6-phospho-beta-galactosidase activity
AM586_15745	COG3842	ATPase activity
AM586_15750	COG0395	ABC-type sugar transport system, permease component
AM586_15765	COG0655	NAD(P)H dehydrogenase (quinone) activity
AM586_15780	COG1597	lipid kinase activity
AM586_15800	COG0589	response to stress
AM586_15805	COG1595	DNA-templated transcription, initiation
AM586_15885	COG4969	Belongs to the N-Me-Phe pilin family
AM586_15910	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM586_15935	COG0432	Pfam Uncharacterised protein family UPF0047
AM586_15945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM586_15950	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AM586_15955	COG2080	2 iron, 2 sulfur cluster binding
AM586_15960	COG3831	ATPase activity
AM586_15965	COG0714	Associated with various cellular activities
AM586_15975	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AM586_15995	COG4191	Histidine kinase
AM586_15995	COG0784	Response regulator, receiver
AM586_16000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM586_16015	COG2175	clavaminate synthase activity
AM586_16040	COG5001	Diguanylate cyclase
AM586_16040	COG2203	Gaf domain
AM586_16040	COG3706	GGDEF domain
AM586_16040	COG4251	negative regulation of phosphorylation
AM586_16045	COG0835	chemotaxis
AM586_16045	COG0784	Response regulator, receiver
AM586_16050	COG1522	sequence-specific DNA binding
AM586_16055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM586_16060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AM586_16065	COG0417	DNA replication proofreading
AM586_16070	COG2833	Protein of unknown function (DUF455)
AM586_16105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AM586_16120	COG0741	lytic transglycosylase activity
AM586_16125	COG2197	response regulator
AM586_16135	COG4537	Required for transformation and DNA binding
AM586_16165	COG1459	type II secretion system
AM586_16225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM586_16230	COG0156	8-amino-7-oxononanoate synthase activity
AM586_16235	COG5002	protein histidine kinase activity
AM586_16250	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AM586_16255	COG0281	malic enzyme
AM586_16255	COG0280	phosphate acetyltransferase
AM586_16260	COG2329	Antibiotic biosynthesis monooxygenase
AM586_16265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM586_16300	COG1304	FMN binding
AM586_16305	COG2860	membrane
AM586_16310	COG2233	PERMEase
AM586_16315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AM586_16325	COG1116	anion transmembrane transporter activity
AM586_16330	COG0390	transport system, permease component
AM586_16340	COG0586	Pfam SNARE associated Golgi protein
AM586_16350	COG3813	Protein conserved in bacteria
AM586_16365	COG0477	Major facilitator Superfamily
AM586_16380	COG0277	FAD linked oxidase domain protein
AM586_16380	COG0247	lactate metabolic process
AM586_16390	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AM586_16395	COG2271	Major facilitator Superfamily
AM586_16400	COG1024	Enoyl-CoA hydratase
AM586_16405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AM586_16410	COG0477	Major facilitator Superfamily
AM586_16415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AM586_16425	COG0318	PFAM AMP-dependent synthetase and ligase
AM586_16435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM586_16445	COG0596	Alpha beta hydrolase
AM586_16455	COG0023	Translation Initiation Factor
AM586_16475	COG3395	kinase activity
AM586_16480	COG0235	Class ii aldolase
AM586_16520	COG3384	dioxygenase
AM586_16525	COG0583	DNA-binding transcription factor activity
AM586_16535	COG0583	DNA-binding transcription factor activity
AM586_16540	COG4948	Mandelate Racemase Muconate Lactonizing
AM586_16545	COG4829	muconolactone delta-isomerase
AM586_16555	COG4638	Rieske (2fe-2S)
AM586_16560	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AM586_16565	COG0543	2 iron, 2 sulfur cluster binding
AM586_16565	COG0633	Ferredoxin
AM586_16570	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_16575	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM586_16580	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM586_16585	COG2814	Major facilitator Superfamily
AM586_16590	COG3135	benzoate transporter
AM586_16595	COG0596	Alpha beta hydrolase
AM586_16605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM586_16625	COG2271	Major facilitator Superfamily
AM586_16635	COG0840	transmembrane signaling receptor activity
AM586_16650	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM586_16655	COG0583	DNA-binding transcription factor activity
AM586_16670	COG1944	ATP diphosphatase activity
AM586_16680	COG4302	ethanolamine ammonia-lyase activity
AM586_16695	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM586_16700	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM586_16705	COG1129	ABC transporter
AM586_16710	COG1879	ABC-type sugar transport system periplasmic component
AM586_16725	COG3507	Belongs to the glycosyl hydrolase 43 family
AM586_16760	COG2017	converts alpha-aldose to the beta-anomer
AM586_16765	COG3940	Belongs to the glycosyl hydrolase 43 family
AM586_16770	COG2211	Major facilitator Superfamily
AM586_16785	COG3940	Belongs to the glycosyl hydrolase 43 family
AM586_16790	COG1846	Transcriptional regulator
AM586_16815	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AM586_16820	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AM586_16825	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AM586_16830	COG0129	dihydroxy-acid dehydratase activity
AM586_16835	COG1012	belongs to the aldehyde dehydrogenase family
AM586_16860	COG1063	alcohol dehydrogenase
AM586_16865	COG0471	metal ion transport
AM586_16880	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM586_16900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AM586_16900	COG0519	Catalyzes the synthesis of GMP from XMP
AM586_16905	COG0516	GMP reductase activity
AM586_16905	COG0517	IMP dehydrogenase activity
AM586_16915	COG2914	Belongs to the UPF0125 (RnfH) family
AM586_16925	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AM586_16940	COG2814	Major facilitator Superfamily
AM586_16945	COG0681	Belongs to the peptidase S26 family
AM586_16980	COG3706	GGDEF domain
AM586_16995	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AM586_17005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM586_17010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AM586_17015	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM586_17020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM586_17025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AM586_17030	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM586_17045	COG0750	zinc metalloprotease
AM586_17050	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AM586_17055	COG0575	Belongs to the CDS family
AM586_17060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AM586_17065	COG0233	cytoplasmic translational termination
AM586_17070	COG0528	UMP kinase activity
AM586_17075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AM586_17080	COG0052	Belongs to the universal ribosomal protein uS2 family
AM586_17085	COG0024	Methionine aminopeptidase
AM586_17090	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AM586_17095	COG1187	pseudouridine synthase activity
AM586_17130	COG0436	Aminotransferase
AM586_17135	COG5002	protein histidine kinase activity
AM586_17170	COG0242	peptide deformylase activity
AM586_17175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AM586_17225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AM586_17230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AM586_17240	COG0431	NADPH-dependent FMN reductase
AM586_17265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AM586_17305	COG0789	Transcriptional regulator
AM586_17315	COG0672	)-iron permease
AM586_17330	COG2801	Transposase and inactivated derivatives
AM586_17355	COG0789	Transcriptional regulator
AM586_17360	COG2217	Heavy metal translocating P-type atpase
AM586_17395	COG2132	Multicopper oxidase
AM586_17400	COG2205	protein histidine kinase activity
AM586_17485	COG1815	bacterial-type flagellum-dependent cell motility
AM586_17495	COG2217	Heavy metal translocating P-type atpase
AM586_17550	COG0789	Transcriptional regulator
AM586_17555	COG2020	methyltransferase activity
AM586_17570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM586_17575	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AM586_17590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM586_17600	COG1007	ATP synthesis coupled electron transport
AM586_17615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM586_17620	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM586_17635	COG0464	growth
AM586_17705	COG0509	glycine decarboxylation via glycine cleavage system
AM586_17715	COG0840	transmembrane signaling receptor activity
AM586_17725	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AM586_17750	COG0776	regulation of translation
AM586_17760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AM586_17765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AM586_17770	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AM586_17775	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AM586_17780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AM586_17790	COG1230	cation diffusion facilitator family transporter
AM586_17795	COG0492	ferredoxin-NADP+ reductase activity
AM586_17815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM586_17820	COG0251	oxidation-reduction process
AM586_17830	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_17840	COG1228	amidohydrolase
AM586_17845	COG1301	dicarboxylic acid transport
AM586_17880	COG4566	intracellular signal transduction
AM586_17900	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_17910	COG5001	Diguanylate cyclase
AM586_17910	COG3300	MHYT domain
AM586_17950	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AM586_17960	COG0473	3-isopropylmalate dehydrogenase activity
AM586_17965	COG0583	DNA-binding transcription factor activity
AM586_17975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM586_17980	COG1074	ATP-dependent DNA helicase activity
AM586_17985	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AM586_17995	COG1505	serine-type exopeptidase activity
AM586_18025	COG0251	oxidation-reduction process
AM586_18045	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AM586_18055	COG0210	DNA helicase
AM586_18075	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AM586_18080	COG0071	Belongs to the small heat shock protein (HSP20) family
AM586_18115	COG1335	isochorismatase
AM586_18125	COG0436	Aminotransferase
AM586_18130	COG5002	protein histidine kinase activity
AM586_18135	COG0025	NhaP-type Na H and K H
AM586_18160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AM586_18220	COG4964	Belongs to the GSP D family
AM586_18280	COG2197	response regulator
AM586_18285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AM586_18300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM586_18340	COG0437	4 iron, 4 sulfur cluster binding
AM586_18360	COG1294	oxidase, subunit
AM586_18365	COG1271	oxidase subunit
AM586_18370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM586_18400	COG2351	hydroxyisourate hydrolase activity
AM586_18430	COG3278	Belongs to the heme-copper respiratory oxidase family
AM586_18445	COG2217	Heavy metal translocating P-type atpase
AM586_18460	COG0840	transmembrane signaling receptor activity
AM586_18465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM586_18525	COG2205	protein histidine kinase activity
AM586_18530	COG1538	Outer membrane efflux protein
AM586_18535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM586_18545	COG2925	Exonuclease
AM586_18555	COG4325	translation initiation factor activity
AM586_18565	COG2890	protein-(glutamine-N5) methyltransferase activity
AM586_18575	COG1566	PFAM secretion protein HlyD family protein
AM586_18580	COG2860	membrane
AM586_18595	COG1802	Transcriptional regulator
AM586_18655	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AM586_18670	COG1473	amidohydrolase
AM586_18685	COG4191	Histidine kinase
AM586_18690	COG4566	intracellular signal transduction
AM586_18710	COG0583	DNA-binding transcription factor activity
AM586_18720	COG5001	Diguanylate cyclase
AM586_18740	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_18750	COG0583	DNA-binding transcription factor activity
AM586_18755	COG1846	Transcriptional regulator
AM586_18760	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_18765	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_18775	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM586_18795	COG1278	Cold shock
AM586_18810	COG3501	Rhs element vgr protein
AM586_18860	COG0322	excinuclease ABC activity
AM586_18865	COG0736	holo-[acyl-carrier-protein] synthase activity
AM586_18870	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AM586_18880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AM586_18895	COG0681	Belongs to the peptidase S26 family
AM586_18900	COG0481	GTPase activity
AM586_18915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM586_18920	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
AM586_18940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AM586_18955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AM586_18960	COG0416	fatty acid biosynthetic process
AM586_18965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AM586_18975	COG0424	maF-like protein
AM586_18980	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AM586_18985	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AM586_18995	COG2224	Isocitrate lyase
AM586_19015	COG0542	response to heat
AM586_19020	COG0038	chloride channel
AM586_19030	COG0314	molybdopterin synthase activity
AM586_19045	COG3214	Protein conserved in bacteria
AM586_19050	COG0420	3'-5' exonuclease activity
AM586_19080	COG0513	Belongs to the DEAD box helicase family
AM586_19115	COG0154	amidase activity
AM586_19125	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AM586_19170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AM586_19175	COG0745	RESPONSE REGULATOR receiver
AM586_19175	COG3706	GGDEF domain
AM586_19180	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AM586_19185	COG0489	protein tyrosine kinase activity
AM586_19190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM586_19190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM586_19215	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AM586_19225	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AM586_19230	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AM586_19235	COG0745	RESPONSE REGULATOR receiver
AM586_19240	COG2201	protein-glutamate methylesterase activity
AM586_19245	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AM586_19250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AM586_19260	COG2198	Histidine kinase
AM586_19260	COG0643	Histidine kinase
AM586_19265	COG0745	RESPONSE REGULATOR receiver
AM586_19275	COG1360	Flagellar Motor Protein
AM586_19285	COG2226	methyltransferase
AM586_19300	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AM586_19310	COG3483	tryptophan 2,3-dioxygenase activity
AM586_19325	COG0326	Molecular chaperone. Has ATPase activity
AM586_19335	COG3795	YCII-related domain
AM586_19340	COG3795	YCII-related domain
AM586_19345	COG4941	Belongs to the sigma-70 factor family
AM586_19350	COG0745	RESPONSE REGULATOR receiver
AM586_19355	COG0642	Histidine kinase
AM586_19360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM586_19360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AM586_19375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM586_19380	COG3706	GGDEF domain
AM586_19380	COG0745	RESPONSE REGULATOR receiver
AM586_19385	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AM586_19390	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AM586_19395	COG0277	FAD linked oxidase domain protein
AM586_19415	COG2171	N-acyltransferase activity
AM586_19425	COG1393	Belongs to the ArsC family
AM586_19430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AM586_19435	COG2890	protein-(glutamine-N5) methyltransferase activity
AM586_19445	COG0835	chemotaxis
AM586_19470	COG0745	RESPONSE REGULATOR receiver
AM586_19475	COG2205	protein histidine kinase activity
AM586_19490	COG2205	protein histidine kinase activity
AM586_19500	COG5001	Diguanylate cyclase
AM586_19500	COG5002	protein histidine kinase activity
AM586_19510	COG0384	phenazine biosynthesis protein PhzF
AM586_19515	COG0640	Transcriptional regulator
AM586_19530	COG0583	DNA-binding transcription factor activity
AM586_19535	COG2814	Major facilitator Superfamily
AM586_19565	COG2851	Citrate transporter
AM586_19575	COG1979	alcohol dehydrogenase
AM586_19595	COG3201	nicotinamide mononucleotide transporter
AM586_19605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM586_19610	COG1136	(ABC) transporter
AM586_19620	COG1136	(ABC) transporter
AM586_19620	COG0577	efflux transmembrane transporter activity
AM586_19630	COG4191	Histidine kinase
AM586_19635	COG4990	cell redox homeostasis
AM586_19635	COG3591	Belongs to the peptidase S1B family
AM586_19665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM586_19670	COG0616	signal peptide processing
AM586_19675	COG4145	pantothenate transmembrane transporter activity
AM586_19700	COG3530	Putative quorum-sensing-regulated virulence factor
AM586_19710	COG1741	Belongs to the pirin family
AM586_19715	COG0745	RESPONSE REGULATOR receiver
AM586_19725	COG1216	Glycosyl transferase, family 2
AM586_19765	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AM586_19785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM586_19795	COG0431	NADPH-dependent FMN reductase
AM586_19820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AM586_19825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AM586_19835	COG0494	nUDIX hydrolase
AM586_19845	COG1007	ATP synthesis coupled electron transport
AM586_19870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM586_19875	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AM586_19880	COG1034	ATP synthesis coupled electron transport
AM586_19890	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AM586_19895	COG0649	NAD binding
AM586_19900	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM586_19910	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM586_19925	COG0149	triose-phosphate isomerase activity
AM586_19955	COG0612	Peptidase, M16
AM586_19970	COG2198	Histidine kinase
AM586_19970	COG0784	Response regulator, receiver
AM586_19970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM586_19970	COG2205	protein histidine kinase activity
AM586_19985	COG2172	sigma factor antagonist activity
AM586_19990	COG1366	Belongs to the anti-sigma-factor antagonist family
AM586_19995	COG1366	Belongs to the anti-sigma-factor antagonist family
AM586_20015	COG1185	polyribonucleotide nucleotidyltransferase activity
AM586_20020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AM586_20065	COG0022	dehydrogenase e1 component
AM586_20065	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM586_20070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AM586_20075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM586_20085	COG1183	phosphatidylcholine synthase activity
AM586_20100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AM586_20105	COG0440	acetolactate synthase activity
AM586_20110	COG0028	Belongs to the TPP enzyme family
AM586_20115	COG0625	glutathione transferase activity
AM586_20145	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AM586_20155	COG2975	iron-sulfur cluster assembly
AM586_20165	COG0443	Heat shock 70 kDa protein
AM586_20170	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AM586_20175	COG0316	Belongs to the HesB IscA family
AM586_20180	COG0822	iron-sulfur transferase activity
AM586_20185	COG1104	cysteine desulfurase activity
AM586_20190	COG1959	2 iron, 2 sulfur cluster binding
AM586_20200	COG0517	IMP dehydrogenase activity
AM586_20210	COG0625	glutathione transferase activity
AM586_20220	COG0583	DNA-binding transcription factor activity
AM586_20235	COG3706	GGDEF domain
AM586_20240	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AM586_20265	COG1538	Outer membrane efflux protein
AM586_20295	COG0784	Response regulator, receiver
AM586_20295	COG4191	Histidine kinase
AM586_20300	COG4251	negative regulation of phosphorylation
AM586_20305	COG0784	Response regulator, receiver
AM586_20310	COG0784	Response regulator, receiver
AM586_20310	COG4191	Histidine kinase
AM586_20320	COG2814	Major facilitator Superfamily
AM586_20325	COG2311	Membrane
AM586_20345	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AM586_20390	COG2095	MarC family integral membrane protein
AM586_20395	COG0583	DNA-binding transcription factor activity
AM586_20400	COG0579	oxidoreductase
AM586_20410	COG0840	transmembrane signaling receptor activity
AM586_20430	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AM586_20435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AM586_20440	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AM586_20445	COG0330	HflC and HflK could
AM586_20450	COG0330	HflC and HflK could
AM586_20460	COG1923	regulation of RNA biosynthetic process
AM586_20465	COG1160	GTP binding
AM586_20480	COG0124	histidyl-tRNA synthetase
AM586_20485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AM586_20490	COG1426	Protein conserved in bacteria
AM586_20500	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AM586_20505	COG0105	UTP biosynthetic process
AM586_20510	COG0670	Belongs to the BI1 family
AM586_20530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AM586_20540	COG1388	LysM domain
AM586_20540	COG4942	peptidase
AM586_20545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AM586_20550	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AM586_20575	COG1115	amino acid carrier protein
AM586_20585	COG1199	ATP-dependent helicase activity
AM586_20595	COG0631	protein serine/threonine phosphatase activity
AM586_20605	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AM586_20610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM586_20620	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM586_20625	COG0567	Dehydrogenase, E1 component
AM586_20650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AM586_20685	COG0745	RESPONSE REGULATOR receiver
AM586_20705	COG0038	chloride channel
AM586_20725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AM586_20755	COG2267	carboxylic ester hydrolase activity
AM586_20770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM586_20775	COG0372	Belongs to the citrate synthase family
AM586_20780	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AM586_20790	COG1053	succinate dehydrogenase
AM586_20795	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AM586_20805	COG2188	Transcriptional regulator
AM586_20825	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AM586_20830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM586_20830	COG2205	protein histidine kinase activity
AM586_20835	COG3128	pkhd-type hydroxylase
AM586_20840	COG4774	siderophore transport
AM586_20850	COG0492	ferredoxin-NADP+ reductase activity
AM586_20865	COG2866	Carboxypeptidase
AM586_20885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AM586_20900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM586_20925	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_20930	COG0583	DNA-binding transcription factor activity
AM586_20935	COG3959	Transketolase, thiamine diphosphate binding domain
AM586_20940	COG3958	Transketolase
AM586_20970	COG3842	ATPase activity
AM586_21000	COG0642	Histidine kinase
AM586_21015	COG0436	Aminotransferase
AM586_21025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AM586_21030	COG2076	Multidrug Resistance protein
AM586_21035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AM586_21040	COG0463	Glycosyl transferase, family 2
AM586_21045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM586_21045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AM586_21050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM586_21050	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AM586_21055	COG0726	polysaccharide deacetylase
AM586_21060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AM586_21065	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AM586_21070	COG0252	asparaginase activity
AM586_21080	COG0306	phosphate transporter
AM586_21090	COG0305	Participates in initiation and elongation during chromosome replication
AM586_21095	COG0359	binds to the 23S rRNA
AM586_21100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AM586_21110	COG0360	Binds together with S18 to 16S ribosomal RNA
AM586_21115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AM586_21140	COG1286	toxin biosynthetic process
AM586_21150	COG0285	dihydrofolate synthase activity
AM586_21155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AM586_21160	COG0159	tryptophan synthase activity
AM586_21165	COG0133	tryptophan synthase activity
AM586_21170	COG0135	phosphoribosylanthranilate isomerase activity
AM586_21175	COG0101	tRNA pseudouridine synthase activity
AM586_21185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AM586_21200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AM586_21205	COG2198	Histidine kinase
AM586_21205	COG0643	Histidine kinase
AM586_21210	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AM586_21225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM586_21240	COG1201	RNA secondary structure unwinding
AM586_21245	COG1793	dna ligase
AM586_21250	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AM586_21250	COG1793	dna ligase
AM586_21255	COG0514	ATP-dependent DNA helicase (RecQ)
AM586_21260	COG3152	Membrane
AM586_21270	COG0450	alkyl hydroperoxide reductase
AM586_21275	COG5002	protein histidine kinase activity
AM586_21275	COG0784	Response regulator, receiver
AM586_21275	COG2205	protein histidine kinase activity
AM586_21285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AM586_21290	COG2205	protein histidine kinase activity
AM586_21290	COG5002	protein histidine kinase activity
AM586_21290	COG0784	Response regulator, receiver
AM586_21305	COG1819	glycosyl
AM586_21310	COG0488	(ABC) transporter
AM586_21350	COG0037	tRNA processing
AM586_21350	COG0590	tRNA wobble adenosine to inosine editing
AM586_21365	COG1132	(ABC) transporter
AM586_21370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AM586_21370	COG0189	ligase activity
AM586_21405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AM586_21415	COG1047	Peptidyl-prolyl cis-trans
AM586_21420	COG2850	peptidyl-arginine hydroxylation
AM586_21430	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AM586_21435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM586_21445	COG0180	Tryptophanyl-tRNA synthetase
AM586_21450	COG1994	Peptidase M50
AM586_21455	COG0009	L-threonylcarbamoyladenylate synthase
AM586_21460	COG0501	Belongs to the peptidase M48B family
AM586_21465	COG0613	PHP domain protein
AM586_21470	COG2267	carboxylic ester hydrolase activity
AM586_21480	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AM586_21485	COG0824	Thioesterase
AM586_21510	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AM586_21515	COG0148	phosphopyruvate hydratase activity
AM586_21520	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AM586_21525	COG0504	CTP synthase activity
AM586_21530	COG0840	transmembrane signaling receptor activity
AM586_21545	COG1473	amidohydrolase
AM586_21550	COG0840	transmembrane signaling receptor activity
AM586_21555	COG0587	DNA-directed DNA polymerase activity
AM586_21565	COG2186	Transcriptional regulator
AM586_21570	COG1620	l-lactate permease
AM586_21575	COG1304	FMN binding
AM586_21600	COG0628	permease
AM586_21610	COG4771	TonB-dependent receptor
AM586_21615	COG0463	Glycosyl transferase, family 2
AM586_21635	COG0642	Histidine kinase
AM586_21640	COG0745	RESPONSE REGULATOR receiver
AM586_21645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM586_21650	COG0071	Belongs to the small heat shock protein (HSP20) family
AM586_21690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM586_21695	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AM586_21705	COG0642	Histidine kinase
AM586_21740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM586_21765	COG4771	TonB-dependent receptor
AM586_21785	COG0443	Heat shock 70 kDa protein
AM586_21790	COG0443	Heat shock 70 kDa protein
AM586_21810	COG0625	glutathione transferase activity
AM586_21830	COG0438	transferase activity, transferring glycosyl groups
AM586_21885	COG1643	Atp-dependent helicase
AM586_21890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AM586_21890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AM586_21895	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AM586_21920	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AM586_21950	COG0800	Aldolase
AM586_21960	COG0166	Belongs to the GPI family
AM586_21975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AM586_21980	COG1737	Transcriptional regulator
AM586_21995	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AM586_22000	COG1956	GAF domain-containing protein
AM586_22005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AM586_22015	COG0477	Major facilitator Superfamily
AM586_22020	COG0583	DNA-binding transcription factor activity
AM586_22035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM586_22040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM586_22045	COG1538	Outer membrane efflux protein
AM586_22050	COG2234	aminopeptidase activity
AM586_22085	COG3850	Histidine kinase
AM586_22085	COG0642	Histidine kinase
AM586_22105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM586_22110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AM586_22115	COG2205	protein histidine kinase activity
AM586_22115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM586_22120	COG0596	Alpha beta hydrolase
AM586_22140	COG0631	protein serine/threonine phosphatase activity
AM586_22145	COG0515	serine threonine protein kinase
AM586_22145	COG1357	PFAM Pentapeptide repeats (8 copies)
AM586_22150	COG1561	YicC-like family, N-terminal region
AM586_22155	COG0194	GDP metabolic process
AM586_22160	COG1758	RNA polymerase activity
AM586_22165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM586_22180	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AM586_22230	COG0745	RESPONSE REGULATOR receiver
AM586_22230	COG3706	GGDEF domain
AM586_22250	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AM586_22270	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AM586_22275	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AM586_22280	COG3507	Belongs to the glycosyl hydrolase 43 family
AM586_22295	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AM586_22315	COG3144	bacterial-type flagellum assembly
AM586_22320	COG1580	Controls the rotational direction of flagella during chemotaxis
AM586_22345	COG1987	bacterial-type flagellum assembly
AM586_22355	COG3402	PFAM membrane-flanked domain
AM586_22370	COG1256	bacterial-type flagellum assembly
AM586_22375	COG3951	Flagellar rod assembly protein muramidase FlgJ
AM586_22375	COG1705	Flagellar rod assembly protein muramidase FlgJ
AM586_22380	COG1706	bacterial-type flagellum-dependent cell motility
AM586_22385	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AM586_22390	COG4786	Flagellar basal body rod
AM586_22395	COG4787	bacterial-type flagellum-dependent cell motility
AM586_22400	COG1749	Flagellar hook protein flgE
AM586_22405	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AM586_22410	COG1558	bacterial-type flagellum-dependent cell motility
AM586_22440	COG4104	PAAR repeat-containing protein
AM586_22445	COG4104	PAAR repeat-containing protein
AM586_22460	COG1360	Flagellar Motor Protein
AM586_22465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AM586_22470	COG1191	sigma factor activity
AM586_22490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM586_22495	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AM586_22515	COG1091	dTDP-4-dehydrorhamnose reductase activity
AM586_22535	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
AM586_22540	COG1187	pseudouridine synthase activity
AM586_22560	COG0546	phosphoglycolate phosphatase activity
AM586_22570	COG1530	ribonuclease E activity
AM586_22580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AM586_22585	COG0303	'Molybdopterin
AM586_22590	COG1322	Protein conserved in bacteria
AM586_22595	COG2346	COG2346, Truncated hemoglobins
AM586_22600	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AM586_22610	COG2766	serine protein kinase
AM586_22615	COG2718	Belongs to the UPF0229 family
AM586_22620	COG2719	SpoVR family
AM586_22645	COG0196	riboflavin kinase activity
AM586_22650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AM586_22655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AM586_22665	COG0756	dUTP diphosphatase activity
AM586_22680	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AM586_22705	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AM586_22710	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AM586_22715	COG0167	dihydroorotate dehydrogenase activity
AM586_22720	COG0667	Aldo Keto reductase
AM586_22725	COG0583	DNA-binding transcription factor activity
AM586_22730	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AM586_22735	COG4208	sulfate ABC transporter
AM586_22740	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AM586_22745	COG0730	response to heat
AM586_22750	COG0450	alkyl hydroperoxide reductase
AM586_22800	COG0559	Belongs to the binding-protein-dependent transport system permease family
AM586_22805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AM586_22810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AM586_22815	COG1047	Peptidyl-prolyl cis-trans
AM586_22820	COG2003	Belongs to the UPF0758 family
AM586_22830	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AM586_22835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AM586_22860	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AM586_22860	COG3264	Mechanosensitive ion channel
AM586_22865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AM586_22865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AM586_22870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AM586_22890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AM586_22915	COG3501	Rhs element vgr protein
AM586_22925	COG0840	transmembrane signaling receptor activity
AM586_22935	COG0129	dihydroxy-acid dehydratase activity
AM586_22950	COG1739	Uncharacterized protein family UPF0029
AM586_22960	COG2814	Major facilitator Superfamily
AM586_22985	COG0840	transmembrane signaling receptor activity
AM586_22995	COG1116	anion transmembrane transporter activity
AM586_23000	COG0395	ABC-type sugar transport system, permease component
AM586_23045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AM586_23060	COG2084	Dehydrogenase
AM586_23075	COG0784	Response regulator, receiver
AM586_23075	COG4191	Histidine kinase
AM586_23085	COG2801	Transposase and inactivated derivatives
AM586_23090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM586_23095	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM586_23105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AM586_23110	COG0339	signal peptide processing
AM586_23140	COG0583	DNA-binding transcription factor activity
AM586_23145	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AM586_23170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AM586_23175	COG0459	protein refolding
AM586_23190	COG0840	transmembrane signaling receptor activity
AM586_23205	COG2223	nitrite transmembrane transporter activity
AM586_23215	COG2721	sulfolactate sulfo-lyase activity
AM586_23225	COG0583	DNA-binding transcription factor activity
AM586_23230	COG2271	Major facilitator Superfamily
AM586_23240	COG3836	Belongs to the HpcH HpaI aldolase family
AM586_23245	COG2084	Dehydrogenase
AM586_23255	COG0837	glucose binding
AM586_23255	COG1737	Transcriptional regulator
AM586_23260	COG0366	Alpha amylase catalytic
AM586_23275	COG0837	glucose binding
AM586_23275	COG1737	Transcriptional regulator
AM586_23280	COG0477	Major facilitator Superfamily
AM586_23300	COG1064	alcohol dehydrogenase
AM586_23330	COG0366	Alpha amylase catalytic
AM586_23335	COG0033	Phosphoglucomutase
AM586_23380	COG0366	Alpha amylase catalytic
AM586_23400	COG0456	acetyltransferase
AM586_23405	COG0402	S-adenosylhomocysteine deaminase activity
AM586_23415	COG1132	(ABC) transporter
AM586_23420	COG1132	(ABC) transporter
AM586_23425	COG3706	GGDEF domain
AM586_23475	COG0840	transmembrane signaling receptor activity
AM586_23480	COG0477	Major facilitator Superfamily
AM586_23545	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AM586_23550	COG0308	aminopeptidase N
AM586_23565	COG1803	Methylglyoxal synthase
AM586_23580	COG0217	transcriptional regulatory protein
AM586_23585	COG0151	Belongs to the GarS family
AM586_23595	COG0408	coproporphyrinogen oxidase activity
AM586_23600	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AM586_23605	COG0799	negative regulation of ribosome biogenesis
AM586_23610	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AM586_23615	COG0424	maF-like protein
AM586_23620	COG1530	ribonuclease E activity
AM586_23635	COG1136	(ABC) transporter
AM586_23640	COG4662	Binding-protein-dependent transport system inner membrane component
AM586_23645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AM586_23650	COG3383	formate dehydrogenase (NAD+) activity
AM586_23665	COG1910	domain protein
AM586_23670	COG0318	PFAM AMP-dependent synthetase and ligase
AM586_23690	COG0859	PFAM glycosyl transferase family 9
AM586_23695	COG1132	(ABC) transporter
AM586_23710	COG1404	Belongs to the peptidase S8 family
AM586_23715	COG0840	transmembrane signaling receptor activity
AM586_23755	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AM586_23765	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AM586_23780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM586_23800	COG0438	transferase activity, transferring glycosyl groups
AM586_23820	COG3274	enterobacterial common antigen metabolic process
AM586_23825	COG0784	Response regulator, receiver
AM586_23825	COG4191	Histidine kinase
AM586_23830	COG0513	Belongs to the DEAD box helicase family
AM586_23875	COG2124	cytochrome p450
AM586_23910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM586_23925	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AM586_23930	COG2081	HI0933 family
AM586_23935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AM586_23940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM586_23945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AM586_23960	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AM586_23965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AM586_23985	COG4974	Belongs to the 'phage' integrase family
AM586_24015	COG4566	intracellular signal transduction
AM586_24025	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AM586_24030	COG0802	atpase or kinase
AM586_24035	COG0860	N-Acetylmuramoyl-L-alanine amidase
AM586_24050	COG0586	Pfam SNARE associated Golgi protein
AM586_24060	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AM586_24065	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AM586_24090	COG0583	DNA-binding transcription factor activity
AM586_24095	COG4948	Mandelate Racemase Muconate Lactonizing
AM586_24105	COG2733	membrane
AM586_24115	COG1960	acyl-CoA dehydrogenase activity
AM586_24130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM586_24130	COG4651	solute:proton antiporter activity
AM586_24155	COG0625	glutathione transferase activity
AM586_24165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AM586_24175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AM586_24180	COG1702	phosphate starvation-inducible protein PhoH
AM586_24185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AM586_24200	COG4535	Mg2 and Co2 transporter CorC
AM586_24205	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AM586_24210	COG0752	glycyl-tRNA synthetase alpha subunit
AM586_24215	COG0751	glycine-tRNA ligase activity
AM586_24220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AM586_24245	COG0859	PFAM glycosyl transferase family 9
AM586_24260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM586_24265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AM586_24280	COG0540	Belongs to the ATCase OTCase family
AM586_24285	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AM586_24290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AM586_24295	COG1678	Uncharacterized ACR, COG1678
AM586_24300	COG0415	Belongs to the DNA photolyase family
AM586_24310	COG0840	transmembrane signaling receptor activity
AM586_24315	COG0835	chemotaxis
AM586_24330	COG1773	rubredoxin
AM586_24340	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AM586_24345	COG1914	H( )-stimulated, divalent metal cation uptake system
AM586_24355	COG0598	Magnesium transport protein CorA
AM586_24360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM586_24365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AM586_24375	COG0557	exoribonuclease II activity
AM586_24380	COG3161	chorismate lyase activity
AM586_24385	COG3150	esterase
AM586_24390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM586_24400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM586_24405	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AM586_24410	COG0511	ligase activity, forming carbon-carbon bonds
AM586_24415	COG0439	Biotin carboxylase
AM586_24420	COG2264	protein methyltransferase activity
AM586_24435	COG0762	integral membrane protein
AM586_24450	COG0438	transferase activity, transferring glycosyl groups
AM586_24455	COG0438	transferase activity, transferring glycosyl groups
AM586_24465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AM586_24490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AM586_24500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM586_24505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM586_24520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AM586_24530	COG1785	Belongs to the alkaline phosphatase family
AM586_24545	COG0583	DNA-binding transcription factor activity
AM586_24550	COG0741	lytic transglycosylase activity
AM586_24555	COG0442	prolyl-tRNA aminoacylation
AM586_24580	COG0659	secondary active sulfate transmembrane transporter activity
AM586_24595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM586_24625	COG0477	Major facilitator Superfamily
AM586_24655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AM586_24660	COG0187	DNA topoisomerase II activity
AM586_24670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM586_24725	COG0165	Argininosuccinate lyase
AM586_24735	COG0546	phosphoglycolate phosphatase activity
AM586_24745	COG1074	ATP-dependent DNA helicase activity
AM586_24750	COG1012	belongs to the aldehyde dehydrogenase family
AM586_24750	COG2030	dehydratase
AM586_24760	COG0183	Belongs to the thiolase family
AM586_24770	COG2050	protein possibly involved in aromatic compounds catabolism
AM586_24775	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM586_24780	COG1024	Enoyl-CoA hydratase
AM586_24785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM586_24790	COG2151	metal-sulfur cluster biosynthetic enzyme
AM586_24795	COG3396	Phenylacetate-CoA oxygenase
AM586_24800	COG3460	Phenylacetate-CoA oxygenase
AM586_24805	COG3396	Phenylacetate-CoA oxygenase
AM586_24820	COG2866	Carboxypeptidase
AM586_24840	COG0312	modulator of DNA gyrase
AM586_24845	COG3028	Belongs to the UPF0307 family
AM586_24850	COG0521	Mo-molybdopterin cofactor biosynthetic process
AM586_24855	COG0400	carboxylic ester hydrolase activity
AM586_24870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AM586_24875	COG0179	Fumarylacetoacetate (FAA) hydrolase
AM586_24890	COG0477	Major facilitator Superfamily
AM586_24905	COG2094	Belongs to the DNA glycosylase MPG family
AM586_24920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AM586_24925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AM586_24935	COG1538	Outer membrane efflux protein
AM586_24985	COG1174	glycine betaine transport
AM586_24990	COG1228	amidohydrolase
AM586_25000	COG0402	S-adenosylhomocysteine deaminase activity
AM586_25010	COG2986	histidine ammonia-lyase
AM586_25015	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AM586_25020	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AM586_25030	COG2169	Transcriptional regulator
AM586_25030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM586_25035	COG2188	Transcriptional regulator
AM586_25045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AM586_25055	COG0254	rRNA binding
AM586_25075	COG0531	amino acid
AM586_25085	COG0582	viral genome integration into host DNA
AM586_25160	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AM586_25180	COG0784	Response regulator, receiver
AM586_25180	COG5002	protein histidine kinase activity
AM586_25180	COG2205	protein histidine kinase activity
AM586_25185	COG1546	Belongs to the CinA family
AM586_25195	COG0612	Peptidase, M16
AM586_25225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AM586_25230	COG0259	pyridoxamine-phosphate oxidase activity
AM586_25235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AM586_25240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AM586_25245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM586_25250	COG1960	acyl-CoA dehydrogenase activity
AM586_25255	COG3047	cAMP biosynthetic process
AM586_25270	COG0009	L-threonylcarbamoyladenylate synthase
AM586_25275	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AM586_25280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AM586_25285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AM586_25295	COG0469	pyruvate kinase activity
AM586_25300	COG0126	phosphoglycerate kinase activity
AM586_25320	COG0429	hydrolase of the alpha beta-hydrolase fold
AM586_25335	COG0315	cyclic pyranopterin monophosphate synthase activity
AM586_25365	COG0823	Involved in the tonB-independent uptake of proteins
AM586_25365	COG1506	peptidase
AM586_25375	COG4969	Belongs to the N-Me-Phe pilin family
AM586_25385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AM586_25390	COG0045	succinate-CoA ligase (ADP-forming) activity
AM586_25400	COG2137	regulation of response to DNA damage stimulus
AM586_25405	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AM586_25410	COG0745	RESPONSE REGULATOR receiver
AM586_25415	COG0642	Histidine kinase
AM586_25425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM586_25435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AM586_25440	COG0560	Phosphoserine phosphatase
AM586_25445	COG0617	tRNA 3'-terminal CCA addition
AM586_25470	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AM586_25485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM586_25490	COG2815	serine threonine protein kinase
AM586_25490	COG0515	serine threonine protein kinase
AM586_25550	COG2204	response regulator
AM586_25560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM586_25565	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AM586_25575	COG2223	nitrite transmembrane transporter activity
AM586_25585	COG3275	phosphorelay sensor kinase activity
AM586_25595	COG1012	belongs to the aldehyde dehydrogenase family
AM586_25610	COG0174	glutamine synthetase
AM586_25615	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AM586_25625	COG1501	Belongs to the glycosyl hydrolase 31 family
AM586_25645	COG1609	Transcriptional regulator
AM586_25650	COG3265	gluconokinase activity
AM586_25655	COG2271	Major facilitator Superfamily
AM586_25660	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM586_25665	COG0288	reversible hydration of carbon dioxide
AM586_25670	COG0484	heat shock protein binding
AM586_25675	COG0443	Heat shock 70 kDa protein
AM586_25680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AM586_25685	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AM586_25690	COG0497	DNA recombination
AM586_25695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AM586_25715	COG1764	response to oxidative stress
AM586_25720	COG0346	lactoylglutathione lyase activity
AM586_25725	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AM586_25740	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AM586_25755	COG1968	undecaprenyl-diphosphatase activity
AM586_25760	COG0514	ATP-dependent DNA helicase (RecQ)
AM586_25775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AM586_25790	COG2198	Histidine kinase
AM586_25790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM586_25790	COG0784	Response regulator, receiver
AM586_25790	COG2205	protein histidine kinase activity
AM586_25810	COG1045	serine acetyltransferase
AM586_25820	COG1573	uracil-dna glycosylase
AM586_25830	COG0596	Alpha beta hydrolase
AM586_25845	COG3852	Histidine kinase
AM586_25850	COG2814	Major facilitator Superfamily
AM586_25870	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AM586_25885	COG0495	leucyl-tRNA aminoacylation
AM586_25895	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AM586_25900	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM586_25905	COG0735	belongs to the Fur family
AM586_25910	COG1420	regulation of RNA biosynthetic process
AM586_25940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AM586_25945	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AM586_25950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM586_25955	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AM586_25960	COG3178	'Phosphotransferase
AM586_25970	COG0006	proline dipeptidase activity
AM586_25975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM586_25980	COG0583	DNA-binding transcription factor activity
AM586_25995	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
AM586_26000	COG1960	acyl-CoA dehydrogenase activity
AM586_26015	COG2301	Belongs to the HpcH HpaI aldolase family
AM586_26030	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AM586_26035	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AM586_26040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AM586_26050	COG0482	sulfurtransferase activity
AM586_26055	COG0835	chemotaxis
AM586_26060	COG0840	transmembrane signaling receptor activity
AM586_26070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AM586_26125	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AM586_26125	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AM586_26130	COG0625	glutathione transferase activity
AM586_26140	COG4771	TonB-dependent receptor
AM586_26145	COG3038	cytochrome b561
AM586_26150	COG2353	YceI-like domain
AM586_26155	COG2353	YceI-like domain
AM586_26165	COG2261	transglycosylase associated protein
AM586_26170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM586_26200	COG0596	Alpha beta hydrolase
AM586_26205	COG0583	DNA-binding transcription factor activity
AM586_26210	COG2814	Major facilitator Superfamily
AM586_26215	COG1902	pentaerythritol trinitrate reductase activity
AM586_26220	COG0531	amino acid
AM586_26225	COG1959	2 iron, 2 sulfur cluster binding
AM586_26230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM586_26230	COG1017	nitric oxide dioxygenase activity
AM586_26240	COG1902	pentaerythritol trinitrate reductase activity
AM586_26250	COG2902	Dehydrogenase
AM586_26255	COG3724	N-succinylarginine dihydrolase activity
AM586_26260	COG1012	belongs to the aldehyde dehydrogenase family
AM586_26275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM586_26300	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AM586_26305	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AM586_26315	COG0302	gtp cyclohydrolase
AM586_26320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM586_26325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM586_26330	COG1862	Preprotein translocase
AM586_26335	COG0343	queuine tRNA-ribosyltransferase activity
AM586_26340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AM586_26380	COG0418	dihydroorotase activity
AM586_26395	COG1309	transcriptional regulator
AM586_26400	COG1126	abc transporter atp-binding protein
AM586_26405	COG1301	dicarboxylic acid transport
AM586_26420	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM586_26430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM586_26435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AM586_26440	COG0583	DNA-binding transcription factor activity
AM586_26450	COG5265	(ABC) transporter
AM586_26455	COG1607	acyl-coa hydrolase
AM586_26460	COG3540	Alkaline phosphatase
AM586_26465	COG0318	PFAM AMP-dependent synthetase and ligase
AM586_26470	COG0318	PFAM AMP-dependent synthetase and ligase
AM586_26480	COG0243	molybdopterin cofactor binding
AM586_26485	COG1473	amidohydrolase
AM586_26490	COG2084	Dehydrogenase
AM586_26495	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AM586_26500	COG0477	Major facilitator Superfamily
AM586_26510	COG1881	PFAM PEBP family protein
AM586_26525	COG1053	succinate dehydrogenase
AM586_26525	COG3976	FMN-binding domain protein
AM586_26530	COG0583	DNA-binding transcription factor activity
AM586_26560	COG2080	2 iron, 2 sulfur cluster binding
AM586_26565	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AM586_26570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM586_26580	COG3279	Response regulator of the LytR AlgR family
AM586_26585	COG3275	phosphorelay sensor kinase activity
AM586_26660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM586_26665	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AM586_26670	COG1127	ABC transporter
AM586_26695	COG2945	thiolester hydrolase activity
AM586_26700	COG1686	Belongs to the peptidase S11 family
AM586_26705	COG4989	oxidoreductase activity
AM586_26715	COG1183	phosphatidylcholine synthase activity
AM586_26740	COG1028	Short-chain dehydrogenase reductase Sdr
AM586_26745	COG0583	DNA-binding transcription factor activity
AM586_26750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AM586_26755	COG0706	membrane insertase activity
AM586_26760	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AM586_26765	COG0594	ribonuclease P activity
AM586_26855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AM586_27090	COG4772	TonB-dependent receptor
AM586_27100	COG4585	Histidine kinase
AM586_27115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM586_27255	COG4974	Belongs to the 'phage' integrase family
AM586_27340	COG4974	Belongs to the 'phage' integrase family
AM586_27395	COG0372	Belongs to the citrate synthase family
AM586_27505	COG1012	belongs to the aldehyde dehydrogenase family
AM586_27510	COG0346	lactoylglutathione lyase activity
AM586_27565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM586_27565	COG0543	2 iron, 2 sulfur cluster binding
AM586_27570	COG2146	nitrite reductase [NAD(P)H] activity
AM586_27585	COG3436	PFAM IS66 Orf2 family protein
AM586_27590	COG4372	Transposase
AM586_27830	COG2205	protein histidine kinase activity
AM586_27835	COG3706	GGDEF domain
AM586_27840	COG3706	GGDEF domain
AM586_27850	COG0438	transferase activity, transferring glycosyl groups
AM586_27860	COG2205	protein histidine kinase activity
AM586_27875	COG2205	protein histidine kinase activity
AM586_27900	COG4412	M6 family metalloprotease domain protein
AM586_27900	COG1404	Belongs to the peptidase S8 family
AM586_27915	COG5001	Diguanylate cyclase
AM586_27955	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AM586_27990	COG2202	Pas domain
AM586_27990	COG2205	protein histidine kinase activity
AM586_27995	COG2205	protein histidine kinase activity
AM586_28005	COG5001	Diguanylate cyclase
AM586_28005	COG3300	MHYT domain
AM586_28010	COG0745	RESPONSE REGULATOR receiver
AM586_28010	COG3706	GGDEF domain
AM586_28020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AM586_28040	COG2823	Periplasmic or secreted lipoprotein
AM586_28055	COG2197	response regulator
AM586_28070	COG2972	Histidine kinase
AM586_28105	COG2205	protein histidine kinase activity
AM586_28145	COG3706	GGDEF domain
AM586_28145	COG4251	negative regulation of phosphorylation
AM586_28145	COG2203	Gaf domain
AM586_28145	COG5001	Diguanylate cyclase
AM586_28170	COG2205	protein histidine kinase activity
AM586_28195	COG5001	Diguanylate cyclase
AM586_28195	COG3300	MHYT domain
AM586_28310	COG2205	protein histidine kinase activity
AM586_28310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain