locus-tag	class	description
MsedC_0003	COG1607	acyl-coa hydrolase
MsedC_0004	COG1056	cytidyltransferase-related domain
MsedC_0004	COG1051	belongs to the nudix hydrolase family
MsedC_0007	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MsedC_0007	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MsedC_0011	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MsedC_0012	COG0077	Prephenate dehydratase
MsedC_0012	COG1605	Chorismate mutase
MsedC_0015	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MsedC_0018	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MsedC_0021	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MsedC_0024	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MsedC_0025	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MsedC_0026	COG0295	cytidine deaminase activity
MsedC_0027	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MsedC_0030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MsedC_0031	COG0281	malic enzyme
MsedC_0033	COG0085	RNA polymerase activity
MsedC_0034	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MsedC_0035	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MsedC_0036	COG1358	cellular component organization or biogenesis
MsedC_0040	COG0049	tRNA binding
MsedC_0041	COG2895	sulfate adenylyltransferase (ATP) activity
MsedC_0042	COG0051	transcription antitermination factor activity, RNA binding
MsedC_0044	COG1797	cobyrinic acid a,c-diamide synthase activity
MsedC_0047	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MsedC_0047	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MsedC_0049	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MsedC_0051	COG0402	S-adenosylhomocysteine deaminase activity
MsedC_0055	COG1201	RNA secondary structure unwinding
MsedC_0057	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MsedC_0058	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MsedC_0059	COG2813	Specifically methylates the guanine in position
MsedC_0069	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MsedC_0070	COG2264	protein methyltransferase activity
MsedC_0071	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MsedC_0073	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MsedC_0083	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MsedC_0088	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MsedC_0089	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MsedC_0093	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MsedC_0095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MsedC_0098	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MsedC_0099	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MsedC_0100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MsedC_0101	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MsedC_0102	COG0255	Belongs to the universal ribosomal protein uL29 family
MsedC_0105	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MsedC_0106	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MsedC_0108	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MsedC_0109	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MsedC_0114	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MsedC_0116	COG0200	Binds to the 23S rRNA
MsedC_0121	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MsedC_0134	COG0438	transferase activity, transferring glycosyl groups
MsedC_0150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MsedC_0151	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MsedC_0154	COG0439	Biotin carboxylase
MsedC_0157	COG1793	dna ligase
MsedC_0158	COG0717	Belongs to the dCTP deaminase family
MsedC_0161	COG2078	PFAM AMMECR1 domain protein
MsedC_0171	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MsedC_0172	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MsedC_0175	COG0189	ligase activity
MsedC_0176	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MsedC_0178	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MsedC_0189	COG1122	ATPase activity
MsedC_0190	COG2860	membrane
MsedC_0194	COG1215	transferase activity, transferring glycosyl groups
MsedC_0195	COG0351	phosphomethylpyrimidine kinase
MsedC_0195	COG0352	thiamine-phosphate diphosphorylase activity
MsedC_0196	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MsedC_0197	COG1234	tRNA 3'-trailer cleavage
MsedC_0201	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MsedC_0207	COG1063	alcohol dehydrogenase
MsedC_0210	COG1492	cobalamin metabolic process
MsedC_0211	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MsedC_0211	COG0519	Catalyzes the synthesis of GMP from XMP
MsedC_0212	COG0028	Belongs to the TPP enzyme family
MsedC_0215	COG0017	Asparaginyl-tRNA synthetase
MsedC_0216	COG0585	pseudouridine synthase activity
MsedC_0219	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MsedC_0221	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MsedC_0222	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MsedC_0222	COG1648	precorrin-2 dehydrogenase activity
MsedC_0223	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MsedC_0224	COG0113	porphobilinogen synthase activity
MsedC_0225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MsedC_0226	COG0181	hydroxymethylbilane synthase activity
MsedC_0231	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MsedC_0232	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MsedC_0236	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MsedC_0237	COG0504	CTP synthase activity
MsedC_0240	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
MsedC_0246	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MsedC_0247	COG1830	Aldolase
MsedC_0249	COG0516	GMP reductase activity
MsedC_0249	COG0517	IMP dehydrogenase activity
MsedC_0251	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MsedC_0252	COG0501	Belongs to the peptidase M48B family
MsedC_0253	COG0405	Gamma-glutamyltransferase
MsedC_0256	COG1444	tRNA N-acetyltransferase activity
MsedC_0262	COG1131	(ABC) transporter
MsedC_0263	COG0589	response to stress
MsedC_0267	COG1444	tRNA N-acetyltransferase activity
MsedC_0282	COG1960	acyl-CoA dehydrogenase activity
MsedC_0283	COG2050	protein possibly involved in aromatic compounds catabolism
MsedC_0284	COG1960	acyl-CoA dehydrogenase activity
MsedC_0285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MsedC_0286	COG1960	acyl-CoA dehydrogenase activity
MsedC_0288	COG2079	MmgE PrpD family protein
MsedC_0289	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MsedC_0290	COG0516	GMP reductase activity
MsedC_0290	COG0517	IMP dehydrogenase activity
MsedC_0291	COG0372	Belongs to the citrate synthase family
MsedC_0300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MsedC_0301	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MsedC_0305	COG0247	lactate metabolic process
MsedC_0306	COG1592	Rubrerythrin
MsedC_0316	COG0437	4 iron, 4 sulfur cluster binding
MsedC_0317	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MsedC_0318	COG1144	Oxidoreductase
MsedC_0319	COG0674	pyruvate-flavodoxin oxidoreductase activity
MsedC_0320	COG1013	pyruvate-flavodoxin oxidoreductase activity
MsedC_0323	COG0477	Major facilitator Superfamily
MsedC_0332	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MsedC_0333	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MsedC_0336	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MsedC_0345	COG0644	oxidoreductase
MsedC_0348	COG1024	Enoyl-CoA hydratase
MsedC_0354	COG3830	Belongs to the UPF0237 family
MsedC_0355	COG2848	UPF0210 protein
MsedC_0356	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MsedC_0365	COG0446	pyridine nucleotide-disulphide oxidoreductase
MsedC_0371	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MsedC_0374	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MsedC_0379	COG1012	belongs to the aldehyde dehydrogenase family
MsedC_0381	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MsedC_0385	COG0425	Belongs to the sulfur carrier protein TusA family
MsedC_0397	COG1024	Enoyl-CoA hydratase
MsedC_0398	COG0183	Belongs to the thiolase family
MsedC_0401	COG1250	3-hydroxyacyl-CoA dehydrogenase
MsedC_0406	COG0318	PFAM AMP-dependent synthetase and ligase
MsedC_0407	COG0823	Involved in the tonB-independent uptake of proteins
MsedC_0407	COG1506	peptidase
MsedC_0407	COG4946	Tricorn protease homolog
MsedC_0411	COG1024	Enoyl-CoA hydratase
MsedC_0412	COG1960	acyl-CoA dehydrogenase activity
MsedC_0413	COG0318	PFAM AMP-dependent synthetase and ligase
MsedC_0418	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MsedC_0420	COG0531	amino acid
MsedC_0435	COG0243	molybdopterin cofactor binding
MsedC_0437	COG0671	phosphoesterase, PA-phosphatase related
MsedC_0438	COG0477	Major facilitator Superfamily
MsedC_0440	COG0655	NAD(P)H dehydrogenase (quinone) activity
MsedC_0442	COG1335	isochorismatase
MsedC_0448	COG0277	FAD linked oxidase domain protein
MsedC_0455	COG0601	transmembrane transport
MsedC_0456	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MsedC_0457	COG0444	Belongs to the ABC transporter superfamily
MsedC_0458	COG4608	Belongs to the ABC transporter superfamily
MsedC_0464	COG0667	Aldo Keto reductase
MsedC_0465	COG0489	protein tyrosine kinase activity
MsedC_0467	COG0039	L-malate dehydrogenase activity
MsedC_0469	COG2814	Major facilitator Superfamily
MsedC_0475	COG0477	Major facilitator Superfamily
MsedC_0476	COG2271	Major facilitator Superfamily
MsedC_0477	COG1063	alcohol dehydrogenase
MsedC_0480	COG2814	Major facilitator Superfamily
MsedC_0483	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MsedC_0499	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MsedC_0505	COG1473	amidohydrolase
MsedC_0511	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MsedC_0516	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MsedC_0519	COG1144	Oxidoreductase
MsedC_0520	COG0674	pyruvate-flavodoxin oxidoreductase activity
MsedC_0521	COG1013	pyruvate-flavodoxin oxidoreductase activity
MsedC_0522	COG0641	radical SAM
MsedC_0523	COG0535	radical SAM domain protein
MsedC_0524	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MsedC_0535	COG1013	pyruvate-flavodoxin oxidoreductase activity
MsedC_0536	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MsedC_0536	COG0674	pyruvate-flavodoxin oxidoreductase activity
MsedC_0545	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MsedC_0556	COG1205	dead DEAH box helicase
MsedC_0556	COG1111	helicase
MsedC_0563	COG0277	FAD linked oxidase domain protein
MsedC_0566	COG1192	Involved in chromosome partitioning
MsedC_0569	COG1252	NADH dehydrogenase
MsedC_0579	COG1131	(ABC) transporter
MsedC_0581	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MsedC_0584	COG0495	leucyl-tRNA aminoacylation
MsedC_0587	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MsedC_0592	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MsedC_0594	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MsedC_0607	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MsedC_0608	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MsedC_0609	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MsedC_0611	COG0430	RNA-3'-phosphate cyclase activity
MsedC_0613	COG0174	glutamine synthetase
MsedC_0620	COG1648	precorrin-2 dehydrogenase activity
MsedC_0620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MsedC_0623	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MsedC_0627	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MsedC_0629	COG1131	(ABC) transporter
MsedC_0635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MsedC_0641	COG0720	synthase
MsedC_0645	COG0483	inositol monophosphate 1-phosphatase activity
MsedC_0646	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MsedC_0652	COG0071	Belongs to the small heat shock protein (HSP20) family
MsedC_0668	COG0183	Belongs to the thiolase family
MsedC_0669	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MsedC_0673	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MsedC_0679	COG2304	oxidoreductase activity
MsedC_0680	COG0714	Associated with various cellular activities
MsedC_0683	COG0303	'Molybdopterin
MsedC_0684	COG0083	homoserine kinase activity
MsedC_0685	COG0626	cystathionine gamma-synthase activity
MsedC_0688	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MsedC_0689	COG1053	succinate dehydrogenase
MsedC_0690	COG0647	UMP catabolic process
MsedC_0693	COG0644	oxidoreductase
MsedC_0697	COG1446	asparaginase
MsedC_0699	COG0644	oxidoreductase
MsedC_0701	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MsedC_0704	COG0189	ligase activity
MsedC_0712	COG2154	pterin-4-alpha-carbinolamine dehydratase
MsedC_0715	COG0538	isocitrate dehydrogenase activity
MsedC_0728	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MsedC_0732	COG2226	methyltransferase
MsedC_0733	COG1573	uracil-dna glycosylase
MsedC_0734	COG1618	nucleotide phosphatase activity, acting on free nucleotides
MsedC_0737	COG0494	nUDIX hydrolase
MsedC_0740	COG0537	adenosine 5'-monophosphoramidase activity
MsedC_0741	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MsedC_0744	COG0561	phosphatase activity
MsedC_0746	COG1011	Hydrolase
MsedC_0749	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MsedC_0751	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MsedC_0754	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MsedC_0757	COG0492	ferredoxin-NADP+ reductase activity
MsedC_0763	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MsedC_0769	COG0154	amidase activity
MsedC_0770	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
MsedC_0771	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MsedC_0772	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MsedC_0772	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MsedC_0776	COG0419	ATPase involved in DNA repair
MsedC_0781	COG0516	GMP reductase activity
MsedC_0781	COG0517	IMP dehydrogenase activity
MsedC_0786	COG0516	GMP reductase activity
MsedC_0786	COG0517	IMP dehydrogenase activity
MsedC_0802	COG1331	Highly conserved protein containing a thioredoxin domain
MsedC_0803	COG1028	Short-chain dehydrogenase reductase Sdr
MsedC_0808	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MsedC_0810	COG0805	protein transport
MsedC_0812	COG1522	sequence-specific DNA binding
MsedC_0819	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MsedC_0821	COG4139	cobalamin transport
MsedC_0829	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MsedC_0830	COG0437	4 iron, 4 sulfur cluster binding
MsedC_0845	COG0066	3-isopropylmalate dehydratase activity
MsedC_0846	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MsedC_0848	COG2815	serine threonine protein kinase
MsedC_0848	COG0515	serine threonine protein kinase
MsedC_0852	COG2239	Acts as a magnesium transporter
MsedC_0855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MsedC_0864	COG1122	ATPase activity
MsedC_0876	COG2814	Major facilitator Superfamily
MsedC_0882	COG2271	Major facilitator Superfamily
MsedC_0884	COG1695	Transcriptional regulator
MsedC_0885	COG4555	ABC transporter
MsedC_0890	COG2235	arginine
MsedC_0894	COG1305	Transglutaminase-like
MsedC_0895	COG2308	Evidence 4 Homologs of previously reported genes of
MsedC_0897	COG2223	nitrite transmembrane transporter activity
MsedC_0898	COG3383	formate dehydrogenase (NAD+) activity
MsedC_0900	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MsedC_0903	COG0804	urea catabolic process
MsedC_0904	COG0831	urea catabolic process
MsedC_0904	COG0832	Belongs to the urease beta subunit family
MsedC_0905	COG0531	amino acid
MsedC_0906	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MsedC_0908	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MsedC_0921	COG1064	alcohol dehydrogenase
MsedC_0922	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MsedC_0923	COG0477	Major facilitator Superfamily
MsedC_0928	COG1523	belongs to the glycosyl hydrolase 13 family
MsedC_0930	COG0455	bacterial-type flagellum organization
MsedC_0931	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MsedC_0932	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MsedC_0942	COG1733	regulation of RNA biosynthetic process
MsedC_0946	COG0409	Hydrogenase expression formation protein
MsedC_0947	COG0298	carbon dioxide binding
MsedC_0949	COG0309	Hydrogenase expression formation protein (HypE)
MsedC_0954	COG1331	Highly conserved protein containing a thioredoxin domain
MsedC_0970	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MsedC_0975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MsedC_0975	COG1648	precorrin-2 dehydrogenase activity
MsedC_0976	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MsedC_0978	COG2046	Belongs to the sulfate adenylyltransferase family
MsedC_0981	COG4454	pyrroloquinoline quinone binding
MsedC_0991	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MsedC_0994	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MsedC_0995	COG0248	Ppx GppA phosphatase
MsedC_0996	COG2062	phosphohistidine phosphatase, SixA
MsedC_1002	COG3387	PFAM Glycoside hydrolase 15-related
MsedC_1006	COG2814	Major facilitator Superfamily
MsedC_1009	COG2368	4-hydroxyphenylacetate
MsedC_1014	COG2814	Major facilitator Superfamily
MsedC_1016	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MsedC_1018	COG0640	Transcriptional regulator
MsedC_1020	COG1028	Short-chain dehydrogenase reductase Sdr
MsedC_1023	COG3511	phospholipase C
MsedC_1024	COG1968	undecaprenyl-diphosphatase activity
MsedC_1025	COG0501	Belongs to the peptidase M48B family
MsedC_1026	COG2814	Major facilitator Superfamily
MsedC_1028	COG0318	PFAM AMP-dependent synthetase and ligase
MsedC_1029	COG1373	ATPase (AAA superfamily
MsedC_1030	COG0589	response to stress
MsedC_1035	COG1401	restriction endodeoxyribonuclease activity
MsedC_1041	COG0515	serine threonine protein kinase
MsedC_1047	COG1122	ATPase activity
MsedC_1052	COG1252	NADH dehydrogenase
MsedC_1054	COG1620	l-lactate permease
MsedC_1060	COG0601	transmembrane transport
MsedC_1062	COG0444	Belongs to the ABC transporter superfamily
MsedC_1063	COG4608	Belongs to the ABC transporter superfamily
MsedC_1067	COG0281	malic enzyme
MsedC_1068	COG0477	Major facilitator Superfamily
MsedC_1069	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MsedC_1070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MsedC_1072	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MsedC_1081	COG1131	(ABC) transporter
MsedC_1092	COG0450	alkyl hydroperoxide reductase
MsedC_1107	COG2271	Major facilitator Superfamily
MsedC_1109	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MsedC_1110	COG0730	response to heat
MsedC_1115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MsedC_1115	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MsedC_1126	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MsedC_1131	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
MsedC_1132	COG2814	Major facilitator Superfamily
MsedC_1132	COG0477	Major facilitator Superfamily
MsedC_1133	COG0277	FAD linked oxidase domain protein
MsedC_1134	COG1012	belongs to the aldehyde dehydrogenase family
MsedC_1138	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MsedC_1139	COG2721	sulfolactate sulfo-lyase activity
MsedC_1140	COG2721	sulfolactate sulfo-lyase activity
MsedC_1142	COG1802	Transcriptional regulator
MsedC_1144	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
MsedC_1152	COG0434	BtpA family
MsedC_1157	COG1203	CRISPR-associated helicase, Cas3
MsedC_1163	COG1518	maintenance of DNA repeat elements
MsedC_1185	COG1518	maintenance of DNA repeat elements
MsedC_1193	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MsedC_1194	COG0584	glycerophosphoryl diester phosphodiesterase
MsedC_1202	COG0668	transmembrane transport
MsedC_1215	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
MsedC_1217	COG1013	pyruvate-flavodoxin oxidoreductase activity
MsedC_1218	COG0674	pyruvate-flavodoxin oxidoreductase activity
MsedC_1229	COG2897	thiosulfate sulfurtransferase activity
MsedC_1231	COG0022	dehydrogenase e1 component
MsedC_1232	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MsedC_1236	COG0427	acetyl-CoA hydrolase
MsedC_1241	COG2271	Major facilitator Superfamily
MsedC_1243	COG0318	PFAM AMP-dependent synthetase and ligase
MsedC_1246	COG0778	Nitroreductase
MsedC_1253	COG1131	(ABC) transporter
MsedC_1267	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MsedC_1270	COG0517	IMP dehydrogenase activity
MsedC_1270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MsedC_1274	COG1091	dTDP-4-dehydrorhamnose reductase activity
MsedC_1287	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MsedC_1300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MsedC_1301	COG0412	Dienelactone hydrolase
MsedC_1308	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MsedC_1309	COG3386	PFAM SMP-30 Gluconolaconase
MsedC_1313	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MsedC_1316	COG1012	belongs to the aldehyde dehydrogenase family
MsedC_1318	COG1505	serine-type exopeptidase activity
MsedC_1320	COG0535	radical SAM domain protein
MsedC_1322	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MsedC_1323	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
MsedC_1327	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MsedC_1327	COG0519	Catalyzes the synthesis of GMP from XMP
MsedC_1328	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MsedC_1332	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MsedC_1336	COG3383	formate dehydrogenase (NAD+) activity
MsedC_1338	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MsedC_1340	COG3387	PFAM Glycoside hydrolase 15-related
MsedC_1361	COG1192	Involved in chromosome partitioning
MsedC_1369	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MsedC_1370	COG1584	GPR1 FUN34 yaaH family protein
MsedC_1371	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MsedC_1372	COG0556	nucleotide-excision repair
MsedC_1376	COG0179	Fumarylacetoacetate (FAA) hydrolase
MsedC_1382	COG0519	Catalyzes the synthesis of GMP from XMP
MsedC_1382	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MsedC_1384	COG1515	deoxyribonuclease V activity
MsedC_1392	COG4581	dead DEAH box helicase
MsedC_1393	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MsedC_1395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MsedC_1395	COG1116	anion transmembrane transporter activity
MsedC_1396	COG0513	Belongs to the DEAD box helicase family
MsedC_1398	COG4172	Belongs to the ABC transporter superfamily
MsedC_1405	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MsedC_1405	COG3608	succinylglutamate desuccinylase aspartoacylase
MsedC_1406	COG1720	tRNA m6t6A37 methyltransferase activity
MsedC_1418	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MsedC_1419	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MsedC_1420	COG0489	protein tyrosine kinase activity
MsedC_1433	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MsedC_1436	COG0297	glycogen (starch) synthase activity
MsedC_1441	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MsedC_1442	COG1250	3-hydroxyacyl-CoA dehydrogenase
MsedC_1443	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MsedC_1445	COG1063	alcohol dehydrogenase
MsedC_1447	COG0651	ATP synthesis coupled electron transport
MsedC_1448	COG0649	NAD binding
MsedC_1449	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MsedC_1453	COG0708	Exodeoxyribonuclease III
MsedC_1462	COG2226	methyltransferase
MsedC_1468	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MsedC_1469	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MsedC_1471	COG0149	triose-phosphate isomerase activity
MsedC_1474	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MsedC_1475	COG0531	amino acid
MsedC_1476	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MsedC_1477	COG3383	formate dehydrogenase (NAD+) activity
MsedC_1482	COG0114	fumarate hydratase activity
MsedC_1487	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MsedC_1492	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MsedC_1494	COG0516	GMP reductase activity
MsedC_1500	COG0095	Lipoate-protein ligase
MsedC_1501	COG0509	glycine decarboxylation via glycine cleavage system
MsedC_1503	COG1489	DNA binding
MsedC_1504	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MsedC_1508	COG0037	tRNA processing
MsedC_1511	COG1716	ATPase activity
MsedC_1515	COG0513	Belongs to the DEAD box helicase family
MsedC_1522	COG0475	glutathione-regulated potassium exporter activity
MsedC_1528	COG0095	Lipoate-protein ligase
MsedC_1530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MsedC_1534	COG2814	Major facilitator Superfamily
MsedC_1544	COG0372	Belongs to the citrate synthase family
MsedC_1547	COG0450	alkyl hydroperoxide reductase
MsedC_1549	COG1335	isochorismatase
MsedC_1550	COG1136	(ABC) transporter
MsedC_1550	COG0577	efflux transmembrane transporter activity
MsedC_1552	COG1136	(ABC) transporter
MsedC_1561	COG0004	ammonium transporteR
MsedC_1564	COG2048	Heterodisulfide reductase, subunit B
MsedC_1567	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MsedC_1570	COG0425	Belongs to the sulfur carrier protein TusA family
MsedC_1571	COG2210	Belongs to the sulfur carrier protein TusA family
MsedC_1582	COG0095	Lipoate-protein ligase
MsedC_1589	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MsedC_1591	COG0509	glycine decarboxylation via glycine cleavage system
MsedC_1599	COG1078	dGTPase activity
MsedC_1600	COG0813	purine-nucleoside phosphorylase activity
MsedC_1604	COG0045	succinate-CoA ligase (ADP-forming) activity
MsedC_1607	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MsedC_1608	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MsedC_1612	COG0589	response to stress
MsedC_1613	COG0297	glycogen (starch) synthase activity
MsedC_1619	COG2096	Adenosyltransferase
MsedC_1627	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MsedC_1628	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MsedC_1630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MsedC_1631	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MsedC_1637	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MsedC_1638	COG0006	proline dipeptidase activity
MsedC_1639	COG0302	gtp cyclohydrolase
MsedC_1640	COG0174	glutamine synthetase
MsedC_1641	COG3842	ATPase activity
MsedC_1642	COG3118	belongs to the thioredoxin family
MsedC_1643	COG0318	PFAM AMP-dependent synthetase and ligase
MsedC_1645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MsedC_1645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MsedC_1659	COG0552	protein localization to endoplasmic reticulum
MsedC_1662	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MsedC_1663	COG0081	regulation of translation
MsedC_1666	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MsedC_1679	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MsedC_1682	COG0126	phosphoglycerate kinase activity
MsedC_1690	COG0719	Fe-S assembly protein
MsedC_1691	COG0396	ATPase activity
MsedC_1695	COG0509	glycine decarboxylation via glycine cleavage system
MsedC_1696	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MsedC_1697	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MsedC_1698	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MsedC_1706	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MsedC_1708	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MsedC_1709	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MsedC_1710	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
MsedC_1717	COG0525	valine-tRNA ligase activity
MsedC_1720	COG0512	Glutamine amidotransferase of anthranilate synthase
MsedC_1720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MsedC_1721	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MsedC_1722	COG0135	phosphoribosylanthranilate isomerase activity
MsedC_1723	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MsedC_1724	COG0159	tryptophan synthase activity
MsedC_1725	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MsedC_1726	COG1254	Belongs to the acylphosphatase family
MsedC_1727	COG1260	myo-inositol-1-phosphate synthase
MsedC_1728	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MsedC_1728	COG0574	Belongs to the PEP-utilizing enzyme family
MsedC_1732	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MsedC_1733	COG0527	aspartate kinase activity
MsedC_1734	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MsedC_1737	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MsedC_1749	COG0018	arginyl-trna synthetase
MsedC_1755	COG0252	asparaginase activity
MsedC_1761	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
MsedC_1771	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MsedC_1771	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MsedC_1774	COG0154	amidase activity
MsedC_1775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MsedC_1776	COG1324	tolerance protein
MsedC_1778	COG0513	Belongs to the DEAD box helicase family
MsedC_1783	COG1110	DNA topoisomerase II activity
MsedC_1785	COG1201	RNA secondary structure unwinding
MsedC_1792	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MsedC_1796	COG1028	Short-chain dehydrogenase reductase Sdr
MsedC_1798	COG0528	UMP kinase activity
MsedC_1800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MsedC_1813	COG1012	belongs to the aldehyde dehydrogenase family
MsedC_1815	COG2368	4-hydroxyphenylacetate
MsedC_1816	COG0179	Fumarylacetoacetate (FAA) hydrolase
MsedC_1817	COG0300	oxidoreductase activity
MsedC_1819	COG0725	ABC transporter, periplasmic molybdate-binding protein
MsedC_1825	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MsedC_1828	COG1234	tRNA 3'-trailer cleavage
MsedC_1830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MsedC_1838	COG2815	serine threonine protein kinase
MsedC_1838	COG0515	serine threonine protein kinase
MsedC_1844	COG1185	polyribonucleotide nucleotidyltransferase activity
MsedC_1850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MsedC_1851	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MsedC_1852	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MsedC_1866	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MsedC_1886	COG0438	transferase activity, transferring glycosyl groups
MsedC_1894	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MsedC_1899	COG2222	sugar isomerase
MsedC_1900	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MsedC_1917	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MsedC_1918	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MsedC_1919	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MsedC_1920	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MsedC_1922	COG3958	Transketolase
MsedC_1923	COG3959	Transketolase, thiamine diphosphate binding domain
MsedC_1928	COG0069	glutamate synthase activity
MsedC_1929	COG0067	glutamate synthase
MsedC_1938	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MsedC_1942	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
MsedC_1944	COG0649	NAD binding
MsedC_1945	COG0649	NAD binding
MsedC_1947	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MsedC_1949	COG0713	ATP synthesis coupled electron transport
MsedC_1950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MsedC_1951	COG1007	ATP synthesis coupled electron transport
MsedC_1952	COG1260	myo-inositol-1-phosphate synthase
MsedC_1956	COG0417	DNA replication proofreading
MsedC_1958	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MsedC_1960	COG1213	nucleotidyl transferase
MsedC_1960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MsedC_1962	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MsedC_1966	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MsedC_1973	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MsedC_1974	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MsedC_1977	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MsedC_1979	COG0028	Belongs to the TPP enzyme family
MsedC_1981	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MsedC_1983	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MsedC_1986	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MsedC_1988	COG0037	tRNA processing
MsedC_1990	COG0495	leucyl-tRNA aminoacylation
MsedC_1993	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MsedC_1994	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MsedC_1995	COG0131	Imidazoleglycerol-phosphate dehydratase
MsedC_1996	COG0107	imidazoleglycerol-phosphate synthase activity
MsedC_1997	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MsedC_1998	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MsedC_1998	COG0140	phosphoribosyl-ATP diphosphatase activity
MsedC_1999	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MsedC_2001	COG2151	metal-sulfur cluster biosynthetic enzyme
MsedC_2002	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MsedC_2003	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MsedC_2006	COG1522	sequence-specific DNA binding
MsedC_2010	COG0167	dihydroorotate dehydrogenase activity
MsedC_2011	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MsedC_2013	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
MsedC_2014	COG0540	Belongs to the ATCase OTCase family
MsedC_2018	COG0704	Plays a role in the regulation of phosphate uptake
MsedC_2021	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MsedC_2024	COG0602	queuosine metabolic process
MsedC_2027	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MsedC_2029	COG0047	phosphoribosylformylglycinamidine synthase activity
MsedC_2030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MsedC_2031	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MsedC_2032	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MsedC_2033	COG0151	Belongs to the GarS family
MsedC_2034	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MsedC_2038	COG0165	Argininosuccinate lyase
MsedC_2039	COG0505	Belongs to the CarA family
MsedC_2040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MsedC_2041	COG0189	ligase activity
MsedC_2043	COG1250	3-hydroxyacyl-CoA dehydrogenase
MsedC_2050	COG1024	Enoyl-CoA hydratase
MsedC_2051	COG0109	protoheme IX farnesyltransferase activity
MsedC_2052	COG0460	homoserine dehydrogenase
MsedC_2054	COG0864	Transcriptional regulator
MsedC_2057	COG0589	response to stress
MsedC_2058	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MsedC_2060	COG0009	L-threonylcarbamoyladenylate synthase
MsedC_2061	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MsedC_2062	COG2379	hydroxypyruvate reductase
MsedC_2065	COG1321	iron dependent repressor
MsedC_2072	COG0303	'Molybdopterin
MsedC_2073	COG0746	molybdenum cofactor guanylyltransferase activity
MsedC_2086	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MsedC_2098	COG0315	cyclic pyranopterin monophosphate synthase activity
MsedC_2099	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MsedC_2100	COG2255	four-way junction helicase activity
MsedC_2101	COG1881	PFAM PEBP family protein
MsedC_2102	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MsedC_2105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MsedC_2106	COG1703	isobutyryl-CoA mutase activity
MsedC_2113	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MsedC_2114	COG0475	glutathione-regulated potassium exporter activity
MsedC_2116	COG0586	Pfam SNARE associated Golgi protein
MsedC_2121	COG1573	uracil-dna glycosylase
MsedC_2122	COG1028	Short-chain dehydrogenase reductase Sdr
MsedC_2125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MsedC_2127	COG1051	belongs to the nudix hydrolase family
MsedC_2128	COG0215	cysteine-tRNA ligase activity
MsedC_2137	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MsedC_2138	COG1960	acyl-CoA dehydrogenase activity
MsedC_2139	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MsedC_2146	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MsedC_2151	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MsedC_2151	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MsedC_2152	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MsedC_2155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MsedC_2160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MsedC_2162	COG1215	transferase activity, transferring glycosyl groups
MsedC_2163	COG1201	RNA secondary structure unwinding
MsedC_2169	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MsedC_2170	COG1058	Belongs to the CinA family
MsedC_2170	COG1546	Belongs to the CinA family
MsedC_2171	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MsedC_2173	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MsedC_2174	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MsedC_2175	COG0024	Methionine aminopeptidase
MsedC_2181	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MsedC_2182	COG1358	cellular component organization or biogenesis
MsedC_2186	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MsedC_2189	COG0528	UMP kinase activity
MsedC_2191	COG1355	regulation of microtubule-based process
MsedC_2192	COG0052	Belongs to the universal ribosomal protein uS2 family
MsedC_2193	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MsedC_2194	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MsedC_2195	COG0200	Binds to the 23S rRNA
MsedC_2197	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MsedC_2198	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MsedC_2199	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MsedC_2201	COG0432	Pfam Uncharacterised protein family UPF0047
MsedC_2203	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MsedC_2205	COG0417	DNA replication proofreading
MsedC_2212	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MsedC_2216	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MsedC_2225	COG0489	protein tyrosine kinase activity
MsedC_2233	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MsedC_2255	COG3328	transposase activity
MsedC_2258	COG4166	transmembrane transport
MsedC_2259	COG0601	transmembrane transport
MsedC_2261	COG0444	Belongs to the ABC transporter superfamily
MsedC_2262	COG4608	Belongs to the ABC transporter superfamily
MsedC_2263	COG3276	selenocysteine insertion sequence binding
MsedC_2266	COG0023	Translation Initiation Factor
MsedC_2267	COG0010	Belongs to the arginase family
MsedC_2268	COG0423	glycine-tRNA ligase activity
MsedC_2274	COG0163	prenyltransferase activity
MsedC_2275	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
MsedC_2278	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MsedC_2280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MsedC_2281	COG0667	Aldo Keto reductase
MsedC_2290	COG1110	DNA topoisomerase II activity
MsedC_2292	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MsedC_2294	COG0557	exoribonuclease II activity
MsedC_2301	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MsedC_2306	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MsedC_2309	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MsedC_2310	COG0371	Dehydrogenase
MsedC_2311	COG1047	Peptidyl-prolyl cis-trans
MsedC_2313	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MsedC_2314	COG1121	(ABC) transporter
MsedC_2315	COG1980	fructose-bisphosphate aldolase activity
MsedC_2320	COG0459	protein refolding
MsedC_2325	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MsedC_2331	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MsedC_2333	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MsedC_2344	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MsedC_2347	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales