locus-tag	class	description
Mevan_0001	COG1773	rubredoxin
Mevan_0001	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Mevan_0002	COG0131	Imidazoleglycerol-phosphate dehydratase
Mevan_0003	COG0697	spore germination
Mevan_0015	COG1234	tRNA 3'-trailer cleavage
Mevan_0020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Mevan_0021	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Mevan_0022	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Mevan_0023	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Mevan_0027	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Mevan_0027	COG0519	Catalyzes the synthesis of GMP from XMP
Mevan_0028	COG0504	CTP synthase activity
Mevan_0031	COG0310	cobalt ion transport
Mevan_0040	COG0473	3-isopropylmalate dehydrogenase activity
Mevan_0044	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Mevan_0046	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Mevan_0048	COG0181	hydroxymethylbilane synthase activity
Mevan_0049	COG0577	efflux transmembrane transporter activity
Mevan_0051	COG0590	tRNA wobble adenosine to inosine editing
Mevan_0055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Mevan_0056	COG0475	glutathione-regulated potassium exporter activity
Mevan_0060	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Mevan_0063	COG0347	Belongs to the P(II) protein family
Mevan_0067	COG0243	molybdopterin cofactor binding
Mevan_0068	COG1233	COG1233 Phytoene dehydrogenase and related
Mevan_0070	COG3259	Nickel-dependent hydrogenase
Mevan_0073	COG3259	Nickel-dependent hydrogenase
Mevan_0075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mevan_0091	COG0484	heat shock protein binding
Mevan_0122	COG1040	competence protein
Mevan_0124	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Mevan_0125	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Mevan_0128	COG1120	ATPase activity
Mevan_0129	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mevan_0130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mevan_0142	COG5002	protein histidine kinase activity
Mevan_0143	COG1454	alcohol dehydrogenase
Mevan_0144	COG5002	protein histidine kinase activity
Mevan_0147	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Mevan_0151	COG0492	ferredoxin-NADP+ reductase activity
Mevan_0157	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Mevan_0158	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Mevan_0169	COG0037	tRNA processing
Mevan_0170	COG0215	cysteine-tRNA ligase activity
Mevan_0172	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Mevan_0173	COG1104	cysteine desulfurase activity
Mevan_0174	COG0822	iron-sulfur transferase activity
Mevan_0175	COG0037	tRNA processing
Mevan_0177	COG1045	serine acetyltransferase
Mevan_0182	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Mevan_0183	COG2813	Specifically methylates the guanine in position
Mevan_0199	COG0438	transferase activity, transferring glycosyl groups
Mevan_0201	COG0438	transferase activity, transferring glycosyl groups
Mevan_0203	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Mevan_0207	COG0288	reversible hydration of carbon dioxide
Mevan_0211	COG0367	asparagine synthase
Mevan_0212	COG0543	2 iron, 2 sulfur cluster binding
Mevan_0213	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Mevan_0216	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Mevan_0219	COG2201	protein-glutamate methylesterase activity
Mevan_0220	COG2198	Histidine kinase
Mevan_0220	COG0643	Histidine kinase
Mevan_0221	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Mevan_0224	COG0459	protein refolding
Mevan_0225	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Mevan_0229	COG1518	maintenance of DNA repeat elements
Mevan_0238	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Mevan_0242	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Mevan_0243	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mevan_0246	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Mevan_0246	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Mevan_0251	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Mevan_0253	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Mevan_0256	COG2201	protein-glutamate methylesterase activity
Mevan_0259	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Mevan_0270	COG1309	transcriptional regulator
Mevan_0274	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Mevan_0276	COG0667	Aldo Keto reductase
Mevan_0277	COG1691	(AIR) carboxylase
Mevan_0291	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Mevan_0293	COG1793	dna ligase
Mevan_0294	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Mevan_0295	COG1846	Transcriptional regulator
Mevan_0313	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Mevan_0317	COG1691	(AIR) carboxylase
Mevan_0328	COG0133	tryptophan synthase activity
Mevan_0330	COG0512	Glutamine amidotransferase of anthranilate synthase
Mevan_0330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Mevan_0331	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Mevan_0332	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Mevan_0337	COG0564	pseudouridine synthase activity
Mevan_0338	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Mevan_0339	COG0708	Exodeoxyribonuclease III
Mevan_0347	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mevan_0350	COG0018	arginyl-trna synthetase
Mevan_0357	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Mevan_0359	COG0330	HflC and HflK could
Mevan_0362	COG1269	ATP hydrolysis coupled proton transport
Mevan_0363	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Mevan_0365	COG1527	subunit (C
Mevan_0367	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Mevan_0368	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Mevan_0374	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Mevan_0376	COG2048	Heterodisulfide reductase, subunit B
Mevan_0382	COG0215	cysteine-tRNA ligase activity
Mevan_0383	COG1739	Uncharacterized protein family UPF0029
Mevan_0385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mevan_0390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Mevan_0392	COG0616	signal peptide processing
Mevan_0399	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Mevan_0400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Mevan_0402	COG1215	transferase activity, transferring glycosyl groups
Mevan_0408	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Mevan_0410	COG1086	Polysaccharide biosynthesis protein
Mevan_0413	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Mevan_0415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Mevan_0416	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Mevan_0419	COG0574	Belongs to the PEP-utilizing enzyme family
Mevan_0419	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Mevan_0421	COG0573	inorganic phosphate transmembrane transporter activity
Mevan_0422	COG0581	inorganic phosphate transmembrane transporter activity
Mevan_0423	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Mevan_0426	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Mevan_0427	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Mevan_0429	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Mevan_0438	COG3958	Transketolase
Mevan_0439	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Mevan_0440	COG3959	Transketolase, thiamine diphosphate binding domain
Mevan_0444	COG5002	protein histidine kinase activity
Mevan_0445	COG0012	GTP binding
Mevan_0447	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Mevan_0449	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Mevan_0449	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Mevan_0450	COG2183	response to ionizing radiation
Mevan_0451	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Mevan_0452	COG0432	Pfam Uncharacterised protein family UPF0047
Mevan_0455	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Mevan_0456	COG0426	domain, Protein
Mevan_0457	COG0426	domain, Protein
Mevan_0458	COG1592	Rubrerythrin
Mevan_0458	COG1773	rubredoxin
Mevan_0459	COG1522	sequence-specific DNA binding
Mevan_0461	COG0352	thiamine-phosphate diphosphorylase activity
Mevan_0463	COG1201	RNA secondary structure unwinding
Mevan_0466	COG1968	undecaprenyl-diphosphatase activity
Mevan_0467	COG2894	cell division
Mevan_0468	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Mevan_0471	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Mevan_0473	COG0649	NAD binding
Mevan_0475	COG2048	Heterodisulfide reductase, subunit B
Mevan_0477	COG2033	superoxide reductase activity
Mevan_0482	COG0426	domain, Protein
Mevan_0483	COG1324	tolerance protein
Mevan_0487	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Mevan_0488	COG0396	ATPase activity
Mevan_0489	COG0719	Fe-S assembly protein
Mevan_0490	COG0463	Glycosyl transferase, family 2
Mevan_0491	COG1183	phosphatidylcholine synthase activity
Mevan_0492	COG0450	alkyl hydroperoxide reductase
Mevan_0498	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mevan_0499	COG1120	ATPase activity
Mevan_0501	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Mevan_0502	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Mevan_0503	COG0235	Class ii aldolase
Mevan_0506	COG1047	Peptidyl-prolyl cis-trans
Mevan_0507	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
Mevan_0512	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Mevan_0513	COG1116	anion transmembrane transporter activity
Mevan_0514	COG0704	Plays a role in the regulation of phosphate uptake
Mevan_0515	COG0019	diaminopimelate decarboxylase activity
Mevan_0518	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Mevan_0519	COG0006	proline dipeptidase activity
Mevan_0521	COG0174	glutamine synthetase
Mevan_0527	COG0183	Belongs to the thiolase family
Mevan_0530	COG1492	cobalamin metabolic process
Mevan_0534	COG1199	ATP-dependent helicase activity
Mevan_0535	COG0058	SHG alpha-glucan phosphorylase activity
Mevan_0536	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Mevan_0540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Mevan_0544	COG0157	Belongs to the NadC ModD family
Mevan_0546	COG0037	tRNA processing
Mevan_0547	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Mevan_0548	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Mevan_0549	COG0314	molybdopterin synthase activity
Mevan_0552	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Mevan_0553	COG1606	tRNA processing
Mevan_0562	COG1229	Formylmethanofuran dehydrogenase subunit A
Mevan_0565	COG0517	IMP dehydrogenase activity
Mevan_0566	COG0517	IMP dehydrogenase activity
Mevan_0568	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Mevan_0571	COG0113	porphobilinogen synthase activity
Mevan_0572	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Mevan_0578	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mevan_0579	COG0252	asparaginase activity
Mevan_0582	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
Mevan_0584	COG0674	pyruvate-flavodoxin oxidoreductase activity
Mevan_0584	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Mevan_0588	COG1053	succinate dehydrogenase
Mevan_0589	COG1993	acr, cog1993
Mevan_0590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Mevan_0600	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Mevan_0605	COG0166	Belongs to the GPI family
Mevan_0609	COG0288	reversible hydration of carbon dioxide
Mevan_0611	COG2116	formate transmembrane transporter activity
Mevan_0613	COG5002	protein histidine kinase activity
Mevan_0614	COG0745	RESPONSE REGULATOR receiver
Mevan_0617	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Mevan_0618	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Mevan_0626	COG1013	pyruvate-flavodoxin oxidoreductase activity
Mevan_0629	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Mevan_0630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Mevan_0631	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Mevan_0632	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Mevan_0634	COG0200	Binds to the 23S rRNA
Mevan_0635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Mevan_0639	COG0148	phosphopyruvate hydratase activity
Mevan_0641	COG0298	carbon dioxide binding
Mevan_0645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Mevan_0647	COG3276	selenocysteine insertion sequence binding
Mevan_0650	COG2890	protein-(glutamine-N5) methyltransferase activity
Mevan_0652	COG0419	ATPase involved in DNA repair
Mevan_0656	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Mevan_0659	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Mevan_0660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Mevan_0661	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Mevan_0663	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Mevan_0664	COG0301	tRNA thio-modification
Mevan_0666	COG0037	tRNA processing
Mevan_0669	COG0517	IMP dehydrogenase activity
Mevan_0669	COG0516	GMP reductase activity
Mevan_0673	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Mevan_0674	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Mevan_0678	COG0049	tRNA binding
Mevan_0679	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Mevan_0681	COG0051	transcription antitermination factor activity, RNA binding
Mevan_0682	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Mevan_0684	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Mevan_0685	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Mevan_0689	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Mevan_0691	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Mevan_0694	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mevan_0697	COG1355	regulation of microtubule-based process
Mevan_0707	COG0436	Aminotransferase
Mevan_0708	COG1196	nuclear chromosome segregation
Mevan_0709	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Mevan_0710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Mevan_0715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Mevan_0719	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Mevan_0720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Mevan_0721	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Mevan_0723	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Mevan_0725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Mevan_0726	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Mevan_0729	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Mevan_0730	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Mevan_0733	COG0201	protein transport
Mevan_0734	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Mevan_0737	COG0717	Belongs to the dCTP deaminase family
Mevan_0738	COG2848	UPF0210 protein
Mevan_0741	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Mevan_0743	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Mevan_0744	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Mevan_0747	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Mevan_0749	COG2340	Cysteine-rich secretory protein family
Mevan_0750	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Mevan_0754	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Mevan_0756	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Mevan_0756	COG0519	Catalyzes the synthesis of GMP from XMP
Mevan_0772	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mevan_0773	COG0649	NAD binding
Mevan_0777	COG0516	GMP reductase activity
Mevan_0777	COG0517	IMP dehydrogenase activity
Mevan_0784	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Mevan_0787	COG1797	cobyrinic acid a,c-diamide synthase activity
Mevan_0789	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Mevan_0790	COG0310	cobalt ion transport
Mevan_0794	COG0521	Mo-molybdopterin cofactor biosynthetic process
Mevan_0795	COG0668	transmembrane transport
Mevan_0796	COG1012	belongs to the aldehyde dehydrogenase family
Mevan_0798	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Mevan_0800	COG0402	S-adenosylhomocysteine deaminase activity
Mevan_0801	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Mevan_0804	COG1242	4 iron, 4 sulfur cluster binding
Mevan_0809	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Mevan_0810	COG0622	Phosphoesterase
Mevan_0812	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Mevan_0813	COG1013	pyruvate-flavodoxin oxidoreductase activity
Mevan_0814	COG0674	pyruvate-flavodoxin oxidoreductase activity
Mevan_0816	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Mevan_0817	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Mevan_0823	COG1115	amino acid carrier protein
Mevan_0824	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Mevan_0827	COG1605	Chorismate mutase
Mevan_0827	COG0287	Prephenate dehydrogenase
Mevan_0836	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Mevan_0837	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Mevan_0838	COG0312	modulator of DNA gyrase
Mevan_0839	COG0571	ribonuclease III activity
Mevan_0840	COG0436	Aminotransferase
Mevan_0841	COG1605	Chorismate mutase
Mevan_0841	COG0077	Prephenate dehydratase
Mevan_0845	COG0126	phosphoglycerate kinase activity
Mevan_0859	COG0089	rRNA binding
Mevan_0860	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Mevan_0861	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Mevan_0865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Mevan_0866	COG0163	prenyltransferase activity
Mevan_0880	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
Mevan_0883	COG0084	hydrolase, TatD family'
Mevan_0885	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Mevan_0886	COG0156	8-amino-7-oxononanoate synthase activity
Mevan_0887	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
Mevan_0890	COG1051	belongs to the nudix hydrolase family
Mevan_0890	COG1056	cytidyltransferase-related domain
Mevan_0893	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Mevan_0895	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Mevan_0896	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Mevan_0897	COG0010	Belongs to the arginase family
Mevan_0899	COG2076	Multidrug Resistance protein
Mevan_0900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Mevan_0901	COG0505	Belongs to the CarA family
Mevan_0911	COG0569	domain protein
Mevan_0912	COG0189	ligase activity
Mevan_0913	COG2264	protein methyltransferase activity
Mevan_0916	COG0469	pyruvate kinase activity
Mevan_0917	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Mevan_0919	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
Mevan_0924	COG0124	histidyl-tRNA synthetase
Mevan_0925	COG2151	metal-sulfur cluster biosynthetic enzyme
Mevan_0926	COG0017	Asparaginyl-tRNA synthetase
Mevan_0927	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Mevan_0928	COG0303	'Molybdopterin
Mevan_0931	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mevan_0939	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Mevan_0944	COG0351	phosphomethylpyrimidine kinase
Mevan_0944	COG1992	Thiamine-phosphate synthase
Mevan_0945	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
Mevan_0947	COG1160	GTP binding
Mevan_0952	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mevan_0954	COG0725	ABC transporter, periplasmic molybdate-binding protein
Mevan_0956	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Mevan_0959	COG0540	Belongs to the ATCase OTCase family
Mevan_0962	COG2875	Belongs to the precorrin methyltransferase family
Mevan_0980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Mevan_0981	COG0175	sulfate reduction
Mevan_0988	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Mevan_0991	COG0028	Belongs to the TPP enzyme family
Mevan_0991	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
Mevan_0996	COG3259	Nickel-dependent hydrogenase
Mevan_0997	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Mevan_1002	COG4145	pantothenate transmembrane transporter activity
Mevan_1004	COG0460	homoserine dehydrogenase
Mevan_1009	COG1185	polyribonucleotide nucleotidyltransferase activity
Mevan_1014	COG0583	DNA-binding transcription factor activity
Mevan_1017	COG1160	GTP binding
Mevan_1019	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Mevan_1025	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Mevan_1031	COG1469	GTP cyclohydrolase I activity
Mevan_1032	COG1181	Belongs to the D-alanine--D-alanine ligase family
Mevan_1058	COG1304	FMN binding
Mevan_1062	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Mevan_1065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Mevan_1066	COG0140	phosphoribosyl-ATP diphosphatase activity
Mevan_1072	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Mevan_1078	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Mevan_1079	COG0347	Belongs to the P(II) protein family
Mevan_1080	COG0004	ammonium transporteR
Mevan_1081	COG0347	Belongs to the P(II) protein family
Mevan_1082	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Mevan_1089	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Mevan_1091	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Mevan_1092	COG0067	glutamate synthase
Mevan_1093	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Mevan_1093	COG0069	glutamate synthase activity
Mevan_1100	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Mevan_1102	COG0297	glycogen (starch) synthase activity
Mevan_1102	COG0438	transferase activity, transferring glycosyl groups
Mevan_1107	COG1379	DNA repair
Mevan_1108	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Mevan_1109	COG1396	sequence-specific DNA binding
Mevan_1111	COG2814	Major facilitator Superfamily
Mevan_1112	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Mevan_1113	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Mevan_1117	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Mevan_1121	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Mevan_1123	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Mevan_1124	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Mevan_1124	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Mevan_1128	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Mevan_1136	COG0076	glutamate decarboxylase activity
Mevan_1138	COG0516	GMP reductase activity
Mevan_1138	COG0517	IMP dehydrogenase activity
Mevan_1140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Mevan_1141	COG0066	3-isopropylmalate dehydratase activity
Mevan_1145	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Mevan_1149	COG0179	Fumarylacetoacetate (FAA) hydrolase
Mevan_1150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Mevan_1152	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Mevan_1154	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Mevan_1154	COG0116	Belongs to the methyltransferase superfamily
Mevan_1157	COG0471	metal ion transport
Mevan_1157	COG0490	domain, Protein
Mevan_1158	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mevan_1163	COG0482	sulfurtransferase activity
Mevan_1166	COG2045	Belongs to the ComB family
Mevan_1168	COG0003	Pfam Anion-transporting ATPase
Mevan_1171	COG0534	Mate efflux family protein
Mevan_1176	COG0390	transport system, permease component
Mevan_1178	COG1078	dGTPase activity
Mevan_1180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mevan_1183	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Mevan_1187	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Mevan_1189	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Mevan_1194	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Mevan_1197	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mevan_1201	COG0864	Transcriptional regulator
Mevan_1207	COG0585	pseudouridine synthase activity
Mevan_1215	COG1465	3-dehydroquinate synthase
Mevan_1218	COG0674	pyruvate-flavodoxin oxidoreductase activity
Mevan_1218	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Mevan_1227	COG0423	glycine-tRNA ligase activity
Mevan_1229	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Mevan_1231	COG2217	Heavy metal translocating P-type atpase
Mevan_1232	COG0640	Transcriptional regulator
Mevan_1233	COG1227	inorganic diphosphatase activity
Mevan_1237	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Mevan_1240	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Mevan_1241	COG1328	CTP reductase activity
Mevan_1242	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
Mevan_1266	COG0045	succinate-CoA ligase (ADP-forming) activity
Mevan_1266	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Mevan_1266	COG1042	CoA-binding domain protein
Mevan_1267	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Mevan_1267	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Mevan_1269	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Mevan_1273	COG0081	regulation of translation
Mevan_1277	COG0668	transmembrane transport
Mevan_1278	COG2095	MarC family integral membrane protein
Mevan_1281	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Mevan_1284	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Mevan_1285	COG1809	phosphosulfolactate synthase activity
Mevan_1289	COG0517	IMP dehydrogenase activity
Mevan_1289	COG0516	GMP reductase activity
Mevan_1291	COG0140	phosphoribosyl-ATP diphosphatase activity
Mevan_1291	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Mevan_1293	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Mevan_1295	COG0105	UTP biosynthetic process
Mevan_1296	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Mevan_1300	COG0409	Hydrogenase expression formation protein
Mevan_1306	COG0083	homoserine kinase activity
Mevan_1312	COG0375	protein maturation
Mevan_1313	COG1773	rubredoxin
Mevan_1315	COG1331	Highly conserved protein containing a thioredoxin domain
Mevan_1316	COG1013	pyruvate-flavodoxin oxidoreductase activity
Mevan_1328	COG1980	fructose-bisphosphate aldolase activity
Mevan_1331	COG0083	homoserine kinase activity
Mevan_1333	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Mevan_1333	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Mevan_1344	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Mevan_1349	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Mevan_1350	COG0511	ligase activity, forming carbon-carbon bonds
Mevan_1350	COG5016	pyruvate
Mevan_1351	COG0439	Biotin carboxylase
Mevan_1355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Mevan_1356	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Mevan_1357	COG1584	GPR1 FUN34 yaaH family protein
Mevan_1359	COG2860	membrane
Mevan_1363	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Mevan_1366	COG0402	S-adenosylhomocysteine deaminase activity
Mevan_1368	COG0066	3-isopropylmalate dehydratase activity
Mevan_1369	COG1121	(ABC) transporter
Mevan_1375	COG0644	oxidoreductase
Mevan_1378	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Mevan_1379	COG0151	Belongs to the GarS family
Mevan_1383	COG0148	phosphopyruvate hydratase activity
Mevan_1384	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Mevan_1388	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Mevan_1390	COG0588	phosphoglycerate mutase activity
Mevan_1395	COG0517	IMP dehydrogenase activity
Mevan_1398	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Mevan_1400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Mevan_1403	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Mevan_1404	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Mevan_1407	COG0516	GMP reductase activity
Mevan_1407	COG0517	IMP dehydrogenase activity
Mevan_1417	COG0084	hydrolase, TatD family'
Mevan_1419	COG2155	Conserved Protein
Mevan_1421	COG0189	ligase activity
Mevan_1422	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Mevan_1424	COG0167	dihydroorotate dehydrogenase activity
Mevan_1425	COG0539	negative regulation of cytoplasmic translation
Mevan_1436	COG0693	protein deglycase activity
Mevan_1442	COG0318	PFAM AMP-dependent synthetase and ligase
Mevan_1447	COG0746	molybdenum cofactor guanylyltransferase activity
Mevan_1454	COG2239	Acts as a magnesium transporter
Mevan_1461	COG0463	Glycosyl transferase, family 2
Mevan_1466	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Mevan_1470	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Mevan_1474	COG0284	orotidine-5'-phosphate decarboxylase activity
Mevan_1484	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Mevan_1486	COG3527	Alpha-acetolactate decarboxylase
Mevan_1488	COG0585	pseudouridine synthase activity
Mevan_1489	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Mevan_1493	COG1125	glycine betaine transport
Mevan_1493	COG0517	IMP dehydrogenase activity
Mevan_1495	COG1397	ADP-ribosylglycohydrolase
Mevan_1499	COG0563	adenylate kinase activity
Mevan_1505	COG0149	triose-phosphate isomerase activity
Mevan_1506	COG1830	Aldolase
Mevan_1509	COG0552	protein localization to endoplasmic reticulum
Mevan_1512	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Mevan_1513	COG1757	Na H antiporter
Mevan_1517	COG1476	TRANSCRIPTIONal
Mevan_1519	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Mevan_1520	COG4895	conserved protein (DUF2196)
Mevan_1524	COG0052	Belongs to the universal ribosomal protein uS2 family
Mevan_1531	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Mevan_1532	COG0826	peptidase U32
Mevan_1533	COG0535	radical SAM domain protein
Mevan_1533	COG1433	Dinitrogenase iron-molybdenum cofactor
Mevan_1534	COG3830	Belongs to the UPF0237 family
Mevan_1538	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Mevan_1540	COG0385	Bile acid
Mevan_1542	COG0440	acetolactate synthase activity
Mevan_1543	COG0028	Belongs to the TPP enzyme family
Mevan_1544	COG2192	nodulation
Mevan_1545	COG0430	RNA-3'-phosphate cyclase activity
Mevan_1548	COG0039	L-malate dehydrogenase activity
Mevan_1549	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Mevan_1556	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Mevan_1562	COG1510	regulation of RNA biosynthetic process
Mevan_1563	COG0577	efflux transmembrane transporter activity
Mevan_1563	COG1136	(ABC) transporter
Mevan_1564	COG0577	efflux transmembrane transporter activity
Mevan_1565	COG1592	Rubrerythrin
Mevan_1569	COG1918	ferrous iron import across plasma membrane
Mevan_1569	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Mevan_1570	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Mevan_1571	COG2252	PERMEase
Mevan_1572	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Mevan_1573	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Mevan_1574	COG0442	prolyl-tRNA aminoacylation
Mevan_1575	COG0495	leucyl-tRNA aminoacylation
Mevan_1577	COG0534	Mate efflux family protein
Mevan_1582	COG0489	protein tyrosine kinase activity
Mevan_1584	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Mevan_1587	COG0598	Magnesium transport protein CorA
Mevan_1590	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Mevan_1594	COG0864	Transcriptional regulator
Mevan_1595	COG1151	hydroxylamine reductase activity
Mevan_1599	COG0556	nucleotide-excision repair
Mevan_1600	COG0322	excinuclease ABC activity
Mevan_1601	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Mevan_1602	COG1722	exodeoxyribonuclease VII activity
Mevan_1603	COG1570	exodeoxyribonuclease VII activity
Mevan_1604	COG0534	Mate efflux family protein
Mevan_1608	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Mevan_1611	COG1280	lysine exporter protein (LysE YggA)
Mevan_1612	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Mevan_1616	COG3842	ATPase activity
Mevan_1622	COG3341	Caulimovirus viroplasmin
Mevan_1622	COG0328	RNA-DNA hybrid ribonuclease activity
Mevan_1623	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Mevan_1624	COG0393	Putative heavy-metal-binding
Mevan_1628	COG4974	Belongs to the 'phage' integrase family
Mevan_1629	COG0513	Belongs to the DEAD box helicase family
Mevan_1647	COG4974	Belongs to the 'phage' integrase family
Mevan_1662	COG1229	Formylmethanofuran dehydrogenase subunit A
Mevan_1665	COG0303	'Molybdopterin
Mevan_1666	COG0725	ABC transporter, periplasmic molybdate-binding protein
Mevan_1667	COG4149	molybdate abc transporter
Mevan_1668	COG1309	transcriptional regulator
Mevan_1669	COG2409	Drug exporters of the RND superfamily
Mevan_1676	COG1136	(ABC) transporter
Mevan_1676	COG0577	efflux transmembrane transporter activity
Mevan_1678	COG1136	(ABC) transporter
Mevan_1683	COG0798	PFAM Bile acid sodium symporter
Mevan_1686	COG0659	secondary active sulfate transmembrane transporter activity
Mevan_1689	COG0668	transmembrane transport
Mevan_1691	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Mevan_1693	COG0473	3-isopropylmalate dehydrogenase activity
Mevan_1694	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Mevan_1695	COG0560	Phosphoserine phosphatase
Mevan_1699	COG0303	'Molybdopterin
Mevan_1700	COG2078	PFAM AMMECR1 domain protein