locus-tag	class	description
Mlab_0003	COG0436	Aminotransferase
Mlab_0005	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Mlab_0015	COG3259	Nickel-dependent hydrogenase
Mlab_0019	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Mlab_0020	COG0514	ATP-dependent DNA helicase (RecQ)
Mlab_0025	COG0318	PFAM AMP-dependent synthetase and ligase
Mlab_0026	COG1122	ATPase activity
Mlab_0027	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Mlab_0032	COG0110	maltose O-acetyltransferase activity
Mlab_0034	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Mlab_0039	COG0017	Asparaginyl-tRNA synthetase
Mlab_0041	COG0747	negative chemotaxis
Mlab_0043	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mlab_0044	COG0444	Belongs to the ABC transporter superfamily
Mlab_0045	COG4608	Belongs to the ABC transporter superfamily
Mlab_0046	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Mlab_0049	COG0674	pyruvate-flavodoxin oxidoreductase activity
Mlab_0050	COG1013	pyruvate-flavodoxin oxidoreductase activity
Mlab_0055	COG1994	Peptidase M50
Mlab_0059	COG1078	dGTPase activity
Mlab_0072	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Mlab_0077	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Mlab_0083	COG0089	rRNA binding
Mlab_0084	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Mlab_0085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Mlab_0087	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Mlab_0088	COG0255	Belongs to the universal ribosomal protein uL29 family
Mlab_0090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Mlab_0091	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Mlab_0094	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Mlab_0096	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Mlab_0097	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Mlab_0101	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Mlab_0116	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Mlab_0117	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Mlab_0118	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Mlab_0120	COG0431	NADPH-dependent FMN reductase
Mlab_0123	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Mlab_0125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Mlab_0131	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Mlab_0131	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Mlab_0132	COG1268	BioY protein
Mlab_0134	COG1122	ATPase activity
Mlab_0137	COG0511	ligase activity, forming carbon-carbon bonds
Mlab_0137	COG5016	pyruvate
Mlab_0138	COG0439	Biotin carboxylase
Mlab_0140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Mlab_0142	COG0527	aspartate kinase activity
Mlab_0142	COG0460	homoserine dehydrogenase
Mlab_0150	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Mlab_0153	COG0284	orotidine-5'-phosphate decarboxylase activity
Mlab_0154	COG1899	peptidyl-lysine modification to peptidyl-hypusine
Mlab_0157	COG0004	ammonium transporteR
Mlab_0158	COG0347	Belongs to the P(II) protein family
Mlab_0162	COG0864	Transcriptional regulator
Mlab_0165	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Mlab_0167	COG4608	Belongs to the ABC transporter superfamily
Mlab_0168	COG0444	Belongs to the ABC transporter superfamily
Mlab_0170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Mlab_0171	COG0601	transmembrane transport
Mlab_0172	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Mlab_0173	COG2033	superoxide reductase activity
Mlab_0174	COG0426	domain, Protein
Mlab_0175	COG1773	rubredoxin
Mlab_0176	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Mlab_0181	COG1418	mRNA catabolic process
Mlab_0187	COG2414	aldehyde ferredoxin oxidoreductase
Mlab_0191	COG0242	peptide deformylase activity
Mlab_0192	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Mlab_0193	COG0577	efflux transmembrane transporter activity
Mlab_0194	COG1136	(ABC) transporter
Mlab_0194	COG0577	efflux transmembrane transporter activity
Mlab_0197	COG1309	transcriptional regulator
Mlab_0199	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Mlab_0202	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Mlab_0203	COG1945	arginine decarboxylase activity
Mlab_0208	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Mlab_0209	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Mlab_0212	COG0242	peptide deformylase activity
Mlab_0213	COG3377	Domain of unknown function (DUF1805)
Mlab_0215	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
Mlab_0216	COG2223	nitrite transmembrane transporter activity
Mlab_0217	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Mlab_0219	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Mlab_0226	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Mlab_0232	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mlab_0233	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Mlab_0234	COG0066	3-isopropylmalate dehydratase activity
Mlab_0235	COG0473	3-isopropylmalate dehydrogenase activity
Mlab_0240	COG2048	Heterodisulfide reductase, subunit B
Mlab_0241	COG1233	COG1233 Phytoene dehydrogenase and related
Mlab_0244	COG0243	molybdopterin cofactor binding
Mlab_0244	COG3383	formate dehydrogenase (NAD+) activity
Mlab_0245	COG1229	Formylmethanofuran dehydrogenase subunit A
Mlab_0247	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Mlab_0248	COG1773	rubredoxin
Mlab_0252	COG0714	Associated with various cellular activities
Mlab_0254	COG2304	oxidoreductase activity
Mlab_0259	COG1122	ATPase activity
Mlab_0263	COG0288	reversible hydration of carbon dioxide
Mlab_0265	COG0822	iron-sulfur transferase activity
Mlab_0267	COG0489	protein tyrosine kinase activity
Mlab_0272	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Mlab_0274	COG0655	NAD(P)H dehydrogenase (quinone) activity
Mlab_0275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Mlab_0276	COG0352	thiamine-phosphate diphosphorylase activity
Mlab_0277	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Mlab_0279	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Mlab_0283	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Mlab_0284	COG2211	Major facilitator Superfamily
Mlab_0291	COG2081	HI0933 family
Mlab_0298	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Mlab_0300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Mlab_0303	COG0640	Transcriptional regulator
Mlab_0307	COG0346	lactoylglutathione lyase activity
Mlab_0308	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Mlab_0309	COG0589	response to stress
Mlab_0310	COG0517	IMP dehydrogenase activity
Mlab_0311	COG3118	belongs to the thioredoxin family
Mlab_0315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Mlab_0316	COG0151	Belongs to the GarS family
Mlab_0317	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Mlab_0319	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Mlab_0327	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Mlab_0330	COG1511	domain protein
Mlab_0330	COG3264	Mechanosensitive ion channel
Mlab_0336	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Mlab_0336	COG0731	radical SAM domain protein
Mlab_0341	COG2894	cell division
Mlab_0342	COG1342	Belongs to the UPF0251 family
Mlab_0343	COG1509	lysine 2,3-aminomutase activity
Mlab_0345	COG1509	lysine 2,3-aminomutase activity
Mlab_0348	COG1104	cysteine desulfurase activity
Mlab_0350	COG0730	response to heat
Mlab_0355	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Mlab_0356	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Mlab_0356	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Mlab_0363	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Mlab_0367	COG0301	tRNA thio-modification
Mlab_0371	COG0513	Belongs to the DEAD box helicase family
Mlab_0374	COG0746	molybdenum cofactor guanylyltransferase activity
Mlab_0377	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Mlab_0380	COG0310	cobalt ion transport
Mlab_0385	COG1918	ferrous iron import across plasma membrane
Mlab_0385	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Mlab_0388	COG1012	belongs to the aldehyde dehydrogenase family
Mlab_0390	COG0477	Major facilitator Superfamily
Mlab_0395	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Mlab_0399	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
Mlab_0404	COG0318	PFAM AMP-dependent synthetase and ligase
Mlab_0408	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Mlab_0408	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Mlab_0411	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Mlab_0412	COG0187	DNA topoisomerase II activity
Mlab_0413	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Mlab_0427	COG0483	inositol monophosphate 1-phosphatase activity
Mlab_0428	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Mlab_0431	COG2081	HI0933 family
Mlab_0436	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Mlab_0442	COG2095	MarC family integral membrane protein
Mlab_0451	COG0517	IMP dehydrogenase activity
Mlab_0457	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Mlab_0461	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Mlab_0463	COG3383	formate dehydrogenase (NAD+) activity
Mlab_0467	COG3842	ATPase activity
Mlab_0476	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Mlab_0477	COG1047	Peptidyl-prolyl cis-trans
Mlab_0479	COG0314	molybdopterin synthase activity
Mlab_0484	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Mlab_0484	COG0674	pyruvate-flavodoxin oxidoreductase activity
Mlab_0485	COG1013	pyruvate-flavodoxin oxidoreductase activity
Mlab_0490	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
Mlab_0491	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Mlab_0496	COG2144	transferase activity, transferring acyl groups
Mlab_0498	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Mlab_0499	COG3842	ATPase activity
Mlab_0511	COG1201	RNA secondary structure unwinding
Mlab_0520	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Mlab_0521	COG1797	cobyrinic acid a,c-diamide synthase activity
Mlab_0523	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Mlab_0524	COG0113	porphobilinogen synthase activity
Mlab_0525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Mlab_0526	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Mlab_0529	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Mlab_0530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Mlab_0532	COG1836	PFAM Integral membrane protein DUF92
Mlab_0534	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Mlab_0535	COG1720	tRNA m6t6A37 methyltransferase activity
Mlab_0537	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Mlab_0542	COG1129	ABC transporter
Mlab_0543	COG0717	Belongs to the dCTP deaminase family
Mlab_0545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Mlab_0551	COG1924	4 iron, 4 sulfur cluster binding
Mlab_0555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Mlab_0556	COG2217	Heavy metal translocating P-type atpase
Mlab_0557	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Mlab_0558	COG1850	ribulose-bisphosphate carboxylase activity
Mlab_0560	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Mlab_0571	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Mlab_0574	COG1229	Formylmethanofuran dehydrogenase subunit A
Mlab_0577	COG0252	asparaginase activity
Mlab_0578	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mlab_0581	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Mlab_0586	COG1739	Uncharacterized protein family UPF0029
Mlab_0588	COG1983	PspC domain protein
Mlab_0593	COG0167	dihydroorotate dehydrogenase activity
Mlab_0598	COG0077	Prephenate dehydratase
Mlab_0598	COG1605	Chorismate mutase
Mlab_0599	COG1605	Chorismate mutase
Mlab_0599	COG0287	Prephenate dehydrogenase
Mlab_0600	COG1830	Aldolase
Mlab_0603	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mlab_0604	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mlab_0605	COG0028	Belongs to the TPP enzyme family
Mlab_0606	COG0440	acetolactate synthase activity
Mlab_0607	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Mlab_0608	COG0066	3-isopropylmalate dehydratase activity
Mlab_0609	COG0473	3-isopropylmalate dehydrogenase activity
Mlab_0611	COG1757	Na H antiporter
Mlab_0613	COG0129	dihydroxy-acid dehydratase activity
Mlab_0615	COG0039	L-malate dehydrogenase activity
Mlab_0616	COG0417	DNA replication proofreading
Mlab_0620	COG1793	dna ligase
Mlab_0622	COG1115	amino acid carrier protein
Mlab_0624	COG0012	GTP binding
Mlab_0633	COG0436	Aminotransferase
Mlab_0643	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Mlab_0644	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Mlab_0645	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Mlab_0648	COG0501	Belongs to the peptidase M48B family
Mlab_0652	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Mlab_0653	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Mlab_0658	COG0539	negative regulation of cytoplasmic translation
Mlab_0660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Mlab_0664	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Mlab_0665	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Mlab_0669	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Mlab_0673	COG1205	dead DEAH box helicase
Mlab_0673	COG1111	helicase
Mlab_0677	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Mlab_0679	COG0535	radical SAM domain protein
Mlab_0679	COG1433	Dinitrogenase iron-molybdenum cofactor
Mlab_0682	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Mlab_0683	COG1304	FMN binding
Mlab_0685	COG0142	geranyltranstransferase activity
Mlab_0709	COG1254	Belongs to the acylphosphatase family
Mlab_0710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Mlab_0714	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Mlab_0717	COG0444	Belongs to the ABC transporter superfamily
Mlab_0719	COG0601	transmembrane transport
Mlab_0721	COG2226	methyltransferase
Mlab_0722	COG0747	negative chemotaxis
Mlab_0723	COG0747	negative chemotaxis
Mlab_0724	COG2223	nitrite transmembrane transporter activity
Mlab_0725	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Mlab_0726	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mlab_0726	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Mlab_0729	COG4172	Belongs to the ABC transporter superfamily
Mlab_0730	COG1342	Belongs to the UPF0251 family
Mlab_0731	COG0489	protein tyrosine kinase activity
Mlab_0743	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Mlab_0745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Mlab_0747	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Mlab_0751	COG0481	GTPase activity
Mlab_0754	COG1227	inorganic diphosphatase activity
Mlab_0761	COG1201	RNA secondary structure unwinding
Mlab_0766	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
Mlab_0769	COG1047	Peptidyl-prolyl cis-trans
Mlab_0771	COG0459	protein refolding
Mlab_0772	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Mlab_0776	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Mlab_0781	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Mlab_0785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Mlab_0787	COG4974	Belongs to the 'phage' integrase family
Mlab_0792	COG0540	Belongs to the ATCase OTCase family
Mlab_0794	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
Mlab_0795	COG0109	protoheme IX farnesyltransferase activity
Mlab_0799	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Mlab_0801	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Mlab_0803	COG0585	pseudouridine synthase activity
Mlab_0806	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Mlab_0817	COG0640	Transcriptional regulator
Mlab_0818	COG0798	PFAM Bile acid sodium symporter
Mlab_0819	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Mlab_0821	COG0640	Transcriptional regulator
Mlab_0822	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Mlab_0837	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Mlab_0839	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Mlab_0844	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Mlab_0846	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Mlab_0852	COG1518	maintenance of DNA repeat elements
Mlab_0853	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Mlab_0854	COG1321	iron dependent repressor
Mlab_0856	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Mlab_0856	COG1918	ferrous iron import across plasma membrane
Mlab_0861	COG4895	conserved protein (DUF2196)
Mlab_0863	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Mlab_0863	COG1042	CoA-binding domain protein
Mlab_0863	COG0045	succinate-CoA ligase (ADP-forming) activity
Mlab_0864	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mlab_0878	COG0714	Associated with various cellular activities
Mlab_0896	COG0438	transferase activity, transferring glycosyl groups
Mlab_0899	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Mlab_0902	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Mlab_0902	COG0493	'glutamate synthase
Mlab_0903	COG0463	Glycosyl transferase, family 2
Mlab_0911	COG0556	nucleotide-excision repair
Mlab_0913	COG3481	metal-dependent phosphohydrolase, HD sub domain
Mlab_0919	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Mlab_0922	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Mlab_0923	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Mlab_0928	COG2176	DNA-directed DNA polymerase activity
Mlab_0936	COG0322	excinuclease ABC activity
Mlab_0939	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Mlab_0941	COG0138	bifunctional purine biosynthesis protein purh
Mlab_0942	COG0484	heat shock protein binding
Mlab_0943	COG0443	Heat shock 70 kDa protein
Mlab_0944	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Mlab_0949	COG2212	antiporter activity
Mlab_0957	COG3260	NADH ubiquinone oxidoreductase 20
Mlab_0958	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Mlab_0958	COG3261	NADH dehydrogenase
Mlab_0959	COG3261	NADH dehydrogenase
Mlab_0959	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Mlab_0960	COG0650	Formate hydrogenlyase subunit 4
Mlab_0965	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Mlab_0967	COG0438	transferase activity, transferring glycosyl groups
Mlab_0970	COG0037	tRNA processing
Mlab_0972	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Mlab_0978	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Mlab_0985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Mlab_0986	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Mlab_0987	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Mlab_0989	COG0004	ammonium transporteR
Mlab_0990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Mlab_0992	COG0778	Nitroreductase
Mlab_0993	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Mlab_0995	COG1363	Peptidase, m42
Mlab_0996	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
Mlab_0999	COG1592	Rubrerythrin
Mlab_1003	COG0528	UMP kinase activity
Mlab_1004	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Mlab_1012	COG1196	nuclear chromosome segregation
Mlab_1014	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Mlab_1015	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Mlab_1017	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mlab_1018	COG1691	(AIR) carboxylase
Mlab_1024	COG3842	ATPase activity
Mlab_1025	COG0725	ABC transporter, periplasmic molybdate-binding protein
Mlab_1030	COG2848	UPF0210 protein
Mlab_1037	COG1982	Orn Lys Arg decarboxylase major
Mlab_1038	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Mlab_1042	COG1120	ATPase activity
Mlab_1047	COG0584	glycerophosphoryl diester phosphodiesterase
Mlab_1050	COG0531	amino acid
Mlab_1053	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Mlab_1054	COG0402	S-adenosylhomocysteine deaminase activity
Mlab_1057	COG3383	formate dehydrogenase (NAD+) activity
Mlab_1059	COG0697	spore germination
Mlab_1060	COG4175	Glycine betaine
Mlab_1060	COG0517	IMP dehydrogenase activity
Mlab_1061	COG4176	ABC-type proline glycine betaine transport system permease component
Mlab_1063	COG4145	pantothenate transmembrane transporter activity
Mlab_1065	COG2217	Heavy metal translocating P-type atpase
Mlab_1070	COG1301	dicarboxylic acid transport
Mlab_1072	COG1797	cobyrinic acid a,c-diamide synthase activity
Mlab_1073	COG0310	cobalt ion transport
Mlab_1074	COG1122	ATPase activity
Mlab_1077	COG1648	precorrin-2 dehydrogenase activity
Mlab_1077	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Mlab_1082	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Mlab_1084	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
Mlab_1085	COG0310	cobalt ion transport
Mlab_1088	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Mlab_1089	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mlab_1097	COG1121	(ABC) transporter
Mlab_1098	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Mlab_1099	COG1492	cobalamin metabolic process
Mlab_1099	COG1492	cobalamin metabolic process
Mlab_1104	COG1199	ATP-dependent helicase activity
Mlab_1104	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Mlab_1112	COG0493	'glutamate synthase
Mlab_1112	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Mlab_1115	COG0704	Plays a role in the regulation of phosphate uptake
Mlab_1117	COG0573	inorganic phosphate transmembrane transporter activity
Mlab_1118	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Mlab_1121	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Mlab_1122	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Mlab_1124	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mlab_1127	COG0237	dephospho-CoA kinase activity
Mlab_1128	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Mlab_1129	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Mlab_1131	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Mlab_1134	COG0504	CTP synthase activity
Mlab_1139	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Mlab_1140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mlab_1141	COG0154	amidase activity
Mlab_1142	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Mlab_1153	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mlab_1154	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Mlab_1156	COG0423	glycine-tRNA ligase activity
Mlab_1157	COG0322	excinuclease ABC activity
Mlab_1160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Mlab_1161	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Mlab_1162	COG0085	RNA polymerase activity
Mlab_1163	COG0085	RNA polymerase activity
Mlab_1166	COG0534	Mate efflux family protein
Mlab_1168	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Mlab_1169	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Mlab_1174	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Mlab_1175	COG0189	ligase activity
Mlab_1178	COG1227	inorganic diphosphatase activity
Mlab_1178	COG0517	IMP dehydrogenase activity
Mlab_1181	COG3852	Histidine kinase
Mlab_1188	COG0475	glutathione-regulated potassium exporter activity
Mlab_1188	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Mlab_1190	COG0546	phosphoglycolate phosphatase activity
Mlab_1206	COG2078	PFAM AMMECR1 domain protein
Mlab_1207	COG0343	queuine tRNA-ribosyltransferase activity
Mlab_1209	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Mlab_1217	COG1269	ATP hydrolysis coupled proton transport
Mlab_1222	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Mlab_1223	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Mlab_1224	COG1394	ATPase activity, coupled to movement of substances
Mlab_1230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Mlab_1231	COG0318	PFAM AMP-dependent synthetase and ligase
Mlab_1232	COG0318	PFAM AMP-dependent synthetase and ligase
Mlab_1234	COG0009	L-threonylcarbamoyladenylate synthase
Mlab_1237	COG0052	Belongs to the universal ribosomal protein uS2 family
Mlab_1238	COG0148	phosphopyruvate hydratase activity
Mlab_1241	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Mlab_1242	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Mlab_1245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Mlab_1246	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Mlab_1247	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Mlab_1251	COG0126	phosphoglycerate kinase activity
Mlab_1254	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Mlab_1255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Mlab_1256	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Mlab_1257	COG1132	(ABC) transporter
Mlab_1258	COG1132	(ABC) transporter
Mlab_1260	COG0174	glutamine synthetase
Mlab_1271	COG0039	L-malate dehydrogenase activity
Mlab_1273	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Mlab_1278	COG4536	flavin adenine dinucleotide binding
Mlab_1280	COG1570	exodeoxyribonuclease VII activity
Mlab_1284	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Mlab_1287	COG0477	Major facilitator Superfamily
Mlab_1289	COG1120	ATPase activity
Mlab_1290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mlab_1291	COG0137	argininosuccinate synthase activity
Mlab_1295	COG2239	Acts as a magnesium transporter
Mlab_1314	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Mlab_1315	COG0571	ribonuclease III activity
Mlab_1317	COG2226	methyltransferase
Mlab_1320	COG0739	heme binding
Mlab_1322	COG1074	ATP-dependent DNA helicase activity
Mlab_1326	COG1151	hydroxylamine reductase activity
Mlab_1327	COG1980	fructose-bisphosphate aldolase activity
Mlab_1328	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Mlab_1332	COG0778	Nitroreductase
Mlab_1332	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Mlab_1333	COG0107	imidazoleglycerol-phosphate synthase activity
Mlab_1335	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Mlab_1335	COG0778	Nitroreductase
Mlab_1345	COG0315	cyclic pyranopterin monophosphate synthase activity
Mlab_1346	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Mlab_1346	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Mlab_1353	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Mlab_1365	COG1234	tRNA 3'-trailer cleavage
Mlab_1370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Mlab_1371	COG0072	phenylalanine-tRNA ligase activity
Mlab_1372	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Mlab_1374	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Mlab_1377	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Mlab_1378	COG1120	ATPase activity
Mlab_1380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Mlab_1382	COG0516	GMP reductase activity
Mlab_1382	COG0517	IMP dehydrogenase activity
Mlab_1384	COG0140	phosphoribosyl-ATP diphosphatase activity
Mlab_1384	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Mlab_1386	COG0442	prolyl-tRNA aminoacylation
Mlab_1387	COG1924	4 iron, 4 sulfur cluster binding
Mlab_1391	COG1122	ATPase activity
Mlab_1392	COG0644	oxidoreductase
Mlab_1393	COG0159	tryptophan synthase activity
Mlab_1395	COG0135	phosphoribosylanthranilate isomerase activity
Mlab_1396	COG0134	indole-3-glycerol-phosphate synthase activity
Mlab_1397	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Mlab_1398	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Mlab_1398	COG0512	Glutamine amidotransferase of anthranilate synthase
Mlab_1400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Mlab_1404	COG0495	leucyl-tRNA aminoacylation
Mlab_1406	COG0140	phosphoribosyl-ATP diphosphatase activity
Mlab_1406	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Mlab_1407	COG2226	methyltransferase
Mlab_1408	COG0107	imidazoleglycerol-phosphate synthase activity
Mlab_1411	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Mlab_1413	COG0484	heat shock protein binding
Mlab_1417	COG0674	pyruvate-flavodoxin oxidoreductase activity
Mlab_1418	COG1013	pyruvate-flavodoxin oxidoreductase activity
Mlab_1420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Mlab_1425	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Mlab_1428	COG1216	Glycosyl transferase, family 2
Mlab_1428	COG1442	glycosyl transferase family 8
Mlab_1433	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Mlab_1435	COG0765	amino acid transport
Mlab_1436	COG1126	abc transporter atp-binding protein
Mlab_1437	COG0765	amino acid transport
Mlab_1441	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Mlab_1444	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Mlab_1453	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
Mlab_1456	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Mlab_1457	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Mlab_1459	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
Mlab_1474	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Mlab_1475	COG0552	protein localization to endoplasmic reticulum
Mlab_1486	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Mlab_1488	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Mlab_1489	COG0569	domain protein
Mlab_1491	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Mlab_1492	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Mlab_1493	COG1215	transferase activity, transferring glycosyl groups
Mlab_1500	COG0105	UTP biosynthetic process
Mlab_1503	COG2116	formate transmembrane transporter activity
Mlab_1504	COG2116	formate transmembrane transporter activity
Mlab_1505	COG0303	'Molybdopterin
Mlab_1510	COG0471	metal ion transport
Mlab_1515	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Mlab_1520	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Mlab_1521	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Mlab_1522	COG1733	regulation of RNA biosynthetic process
Mlab_1523	COG1151	hydroxylamine reductase activity
Mlab_1526	COG1418	mRNA catabolic process
Mlab_1543	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Mlab_1549	COG1725	Transcriptional regulator
Mlab_1553	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
Mlab_1571	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Mlab_1572	COG2890	protein-(glutamine-N5) methyltransferase activity
Mlab_1577	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Mlab_1581	COG0081	regulation of translation
Mlab_1582	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Mlab_1586	COG1234	tRNA 3'-trailer cleavage
Mlab_1613	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Mlab_1614	COG0049	tRNA binding
Mlab_1617	COG0602	queuosine metabolic process
Mlab_1618	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Mlab_1622	COG3260	NADH ubiquinone oxidoreductase 20
Mlab_1624	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Mlab_1624	COG2111	Na H antiporter
Mlab_1626	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Mlab_1627	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Mlab_1630	COG1476	TRANSCRIPTIONal
Mlab_1633	COG0475	glutathione-regulated potassium exporter activity
Mlab_1639	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Mlab_1640	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Mlab_1641	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Mlab_1649	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Mlab_1652	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Mlab_1653	COG1465	3-dehydroquinate synthase
Mlab_1654	COG1830	Aldolase
Mlab_1656	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Mlab_1657	COG0352	thiamine-phosphate diphosphorylase activity
Mlab_1658	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Mlab_1659	COG0135	phosphoribosylanthranilate isomerase activity
Mlab_1663	COG0157	Belongs to the NadC ModD family
Mlab_1664	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Mlab_1665	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
Mlab_1666	COG3655	Transcriptional regulator
Mlab_1675	COG0101	tRNA pseudouridine synthase activity
Mlab_1676	COG0655	NAD(P)H dehydrogenase (quinone) activity
Mlab_1691	COG3153	acetyltransferase
Mlab_1693	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Mlab_1701	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Mlab_1701	COG3264	Mechanosensitive ion channel
Mlab_1703	COG0330	HflC and HflK could
Mlab_1711	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Mlab_1714	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Mlab_1716	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Mlab_1719	COG1120	ATPase activity
Mlab_1734	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Mlab_1736	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Mlab_1737	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Mlab_1738	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Mlab_1741	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Mlab_1751	COG4581	dead DEAH box helicase
Mlab_1756	COG0521	Mo-molybdopterin cofactor biosynthetic process