locus-tag	class	description
U737_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
U737_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
U737_00020	COG0187	DNA topoisomerase II activity
U737_00075	COG2135	peptidase activity
U737_00160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U737_00165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U737_00170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
U737_00175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
U737_00180	COG0189	ligase activity
U737_00190	COG1678	Uncharacterized ACR, COG1678
U737_00195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
U737_00200	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
U737_00205	COG0540	Belongs to the ATCase OTCase family
U737_00220	COG0714	Associated with various cellular activities
U737_00250	COG1253	flavin adenine dinucleotide binding
U737_00270	COG0494	nUDIX hydrolase
U737_00275	COG0840	transmembrane signaling receptor activity
U737_00280	COG1011	Hydrolase
U737_00300	COG4178	(ABC) transporter
U737_00315	COG0314	molybdopterin synthase activity
U737_00320	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
U737_00325	COG0315	cyclic pyranopterin monophosphate synthase activity
U737_00345	COG1530	ribonuclease E activity
U737_00350	COG0424	maF-like protein
U737_00355	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
U737_00365	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U737_00375	COG3002	Belongs to the UPF0753 family
U737_00395	COG0288	reversible hydration of carbon dioxide
U737_00400	COG0659	secondary active sulfate transmembrane transporter activity
U737_00420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
U737_00425	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
U737_00435	COG1561	YicC-like family, N-terminal region
U737_00445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U737_00450	COG1028	Short-chain dehydrogenase reductase Sdr
U737_00475	COG3706	GGDEF domain
U737_00485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
U737_00500	COG1715	Restriction endonuclease
U737_00545	COG2271	Major facilitator Superfamily
U737_00580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
U737_00595	COG0604	alcohol dehydrogenase
U737_00600	COG1028	Short-chain dehydrogenase reductase Sdr
U737_00610	COG1492	cobalamin metabolic process
U737_00615	COG0778	Nitroreductase
U737_00620	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
U737_00630	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
U737_00640	COG0589	response to stress
U737_00650	COG0488	(ABC) transporter
U737_00665	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U737_00685	COG0134	indole-3-glycerol-phosphate synthase activity
U737_00700	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
U737_00705	COG3657	addiction module killer protein
U737_00710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
U737_00725	COG4115	mRNA cleavage
U737_00735	COG0512	Glutamine amidotransferase of anthranilate synthase
U737_00770	COG0459	protein refolding
U737_00780	COG0543	2 iron, 2 sulfur cluster binding
U737_00780	COG0633	Ferredoxin
U737_00805	COG3350	monooxygenase activity
U737_00820	COG3158	transport of potassium into the cell
U737_00840	COG0189	ligase activity
U737_00845	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
U737_00850	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
U737_00855	COG0235	Class ii aldolase
U737_00880	COG0330	HflC and HflK could
U737_00900	COG0714	Associated with various cellular activities
U737_00920	COG2951	lytic endotransglycosylase activity
U737_00945	COG1234	tRNA 3'-trailer cleavage
U737_00985	COG1301	dicarboxylic acid transport
U737_00990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
U737_00995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
U737_01000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
U737_01005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
U737_01040	COG4636	protein conserved in cyanobacteria
U737_01070	COG3712	iron ion homeostasis
U737_01130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U737_01135	COG3028	Belongs to the UPF0307 family
U737_01145	COG2974	May be involved in recombination
U737_01150	COG1376	ErfK ybiS ycfS ynhG family protein
U737_01165	COG0033	Phosphoglucomutase
U737_01175	COG1278	Cold shock
U737_01190	COG1194	a g-specific adenine glycosylase
U737_01195	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
U737_01210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
U737_01235	COG0508	dehydrogenase complex catalyzes the overall conversion of
U737_01240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
U737_01255	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
U737_01270	COG5001	Diguanylate cyclase
U737_01270	COG3300	MHYT domain
U737_01275	COG2814	Major facilitator Superfamily
U737_01285	COG1309	transcriptional regulator
U737_01305	COG1765	OsmC-like protein
U737_01310	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
U737_01320	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
U737_01325	COG2967	ApaG domain
U737_01335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
U737_01345	COG0457	Tetratricopeptide repeat
U737_01345	COG0515	serine threonine protein kinase
U737_01360	COG0671	phosphoesterase, PA-phosphatase related
U737_01385	COG1968	undecaprenyl-diphosphatase activity
U737_01405	COG1360	Flagellar Motor Protein
U737_01420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
U737_01435	COG0432	Pfam Uncharacterised protein family UPF0047
U737_01440	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
U737_01450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
U737_01455	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
U737_01460	COG2852	Protein conserved in bacteria
U737_01465	COG0284	orotidine-5'-phosphate decarboxylase activity
U737_01470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
U737_01480	COG3594	Acyltransferase
U737_01485	COG2244	polysaccharide biosynthetic process
U737_01495	COG0438	transferase activity, transferring glycosyl groups
U737_01500	COG3307	-O-antigen
U737_01505	COG1216	Glycosyl transferase, family 2
U737_01505	COG0463	Glycosyl transferase, family 2
U737_01510	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
U737_01520	COG0438	transferase activity, transferring glycosyl groups
U737_01525	COG0438	transferase activity, transferring glycosyl groups
U737_01585	COG0642	Histidine kinase
U737_01595	COG0538	isocitrate dehydrogenase activity
U737_01625	COG0606	chelatase, subunit chli
U737_01635	COG0450	alkyl hydroperoxide reductase
U737_01665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
U737_01690	COG0840	transmembrane signaling receptor activity
U737_01695	COG2198	Histidine kinase
U737_01695	COG0643	Histidine kinase
U737_01710	COG0840	transmembrane signaling receptor activity
U737_01720	COG3219	Protein conserved in bacteria
U737_01725	COG3220	belongs to the UPF0276 family
U737_01740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
U737_01750	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
U737_01765	COG0300	oxidoreductase activity
U737_01785	COG1615	UPF0182 protein
U737_01815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
U737_01830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
U737_01850	COG0840	transmembrane signaling receptor activity
U737_01860	COG0745	RESPONSE REGULATOR receiver
U737_01870	COG0525	valine-tRNA ligase activity
U737_01890	COG1238	metal cluster binding
U737_01905	COG0166	Belongs to the GPI family
U737_01930	COG5002	protein histidine kinase activity
U737_01950	COG2197	response regulator
U737_01955	COG0784	Response regulator, receiver
U737_01955	COG2198	Histidine kinase
U737_01955	COG2205	protein histidine kinase activity
U737_01980	COG3046	protein related to deoxyribodipyrimidine photolyase
U737_01990	COG0415	Belongs to the DNA photolyase family
U737_02000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U737_02015	COG0009	L-threonylcarbamoyladenylate synthase
U737_02020	COG0511	ligase activity, forming carbon-carbon bonds
U737_02020	COG5016	pyruvate
U737_02025	COG0439	Biotin carboxylase
U737_02040	COG0463	Glycosyl transferase, family 2
U737_02050	COG4181	ATPase activity
U737_02065	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
U737_02070	COG0745	RESPONSE REGULATOR receiver
U737_02075	COG3437	response regulator, receiver
U737_02095	COG0181	hydroxymethylbilane synthase activity
U737_02105	COG1254	Belongs to the acylphosphatase family
U737_02110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
U737_02110	COG0116	Belongs to the methyltransferase superfamily
U737_02115	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
U737_02145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
U737_02150	COG0109	protoheme IX farnesyltransferase activity
U737_02155	COG0612	Peptidase, M16
U737_02160	COG0612	Peptidase, M16
U737_02165	COG0742	ribosomal rna small subunit methyltransferase
U737_02170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
U737_02175	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
U737_02180	COG1064	alcohol dehydrogenase
U737_02195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
U737_02245	COG1451	nucleotide metabolic process
U737_02250	COG0517	IMP dehydrogenase activity
U737_02260	COG0628	permease
U737_02265	COG0521	Mo-molybdopterin cofactor biosynthetic process
U737_02270	COG2363	Small membrane protein
U737_02280	COG0308	aminopeptidase N
U737_02285	COG0131	Imidazoleglycerol-phosphate dehydratase
U737_02290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
U737_02295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
U737_02300	COG0107	imidazoleglycerol-phosphate synthase activity
U737_02305	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
U737_02335	COG1203	CRISPR-associated helicase, Cas3
U737_02340	COG1598	PFAM Uncharacterised protein family UPF0150
U737_02385	COG1518	maintenance of DNA repeat elements
U737_02390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U737_02405	COG2878	Part of a membrane complex involved in electron transport
U737_02410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U737_02410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U737_02435	COG1376	ErfK ybiS ycfS ynhG family protein
U737_02440	COG0489	protein tyrosine kinase activity
U737_02445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
U737_02450	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
U737_02455	COG0211	Belongs to the bacterial ribosomal protein bL27 family
U737_02460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
U737_02465	COG0142	geranyltranstransferase activity
U737_02475	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
U737_02490	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
U737_02495	COG0237	dephospho-CoA kinase activity
U737_02500	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
U737_02505	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
U737_02510	COG0494	nUDIX hydrolase
U737_02515	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
U737_02565	COG2197	response regulator
U737_02570	COG4585	Histidine kinase
U737_02580	COG3323	Protein of unknown function (DUF1653)
U737_02580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
U737_02585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
U737_02600	COG2857	Cytochrome c1
U737_02605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
U737_02610	COG0723	plastoquinol--plastocyanin reductase activity
U737_02615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
U737_02660	COG0837	glucose binding
U737_02670	COG0717	Belongs to the dCTP deaminase family
U737_02690	COG3391	amine dehydrogenase activity
U737_02705	COG1858	cytochrome C peroxidase
U737_02720	COG5002	protein histidine kinase activity
U737_02720	COG5001	Diguanylate cyclase
U737_02720	COG3447	MASE1 domain protein
U737_02730	COG1294	oxidase, subunit
U737_02740	COG1546	Belongs to the CinA family
U737_02745	COG0501	Belongs to the peptidase M48B family
U737_02755	COG2171	N-acyltransferase activity
U737_02780	COG1393	Belongs to the ArsC family
U737_02785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U737_02800	COG2003	Belongs to the UPF0758 family
U737_02830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
U737_02900	COG0642	Histidine kinase
U737_02960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
U737_02990	COG0732	type I restriction modification DNA specificity domain
U737_03005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U737_03030	COG3344	reverse transcriptase
U737_03080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U737_03090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
U737_03105	COG2135	peptidase activity
U737_03130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
U737_03135	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
U737_03215	COG0681	Belongs to the peptidase S26 family
U737_03295	COG0629	single-stranded DNA binding
U737_03370	COG2003	Belongs to the UPF0758 family
U737_03395	COG3959	Transketolase, thiamine diphosphate binding domain
U737_03400	COG3958	Transketolase
U737_03420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U737_03465	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
U737_03465	COG2755	lipolytic protein G-D-S-L family
U737_03475	COG0463	Glycosyl transferase, family 2
U737_03485	COG2192	nodulation
U737_03520	COG0579	oxidoreductase
U737_03525	COG2169	Transcriptional regulator
U737_03525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
U737_03580	COG0459	protein refolding
U737_03590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
U737_03595	COG1595	DNA-templated transcription, initiation
U737_03625	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
U737_03630	COG4206	TonB-dependent receptor
U737_03675	COG1666	GTP binding
U737_03690	COG0433	COG0433 Predicted ATPase
U737_03735	COG0175	sulfate reduction
U737_03775	COG1943	Transposase
U737_03800	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
U737_03810	COG0840	transmembrane signaling receptor activity
U737_03820	COG0514	ATP-dependent DNA helicase (RecQ)
U737_03825	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
U737_03835	COG0154	amidase activity
U737_03840	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
U737_03845	COG1077	Cell shape determining protein MreB Mrl
U737_03850	COG1792	Involved in formation and maintenance of cell shape
U737_03855	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
U737_03860	COG0768	penicillin binding
U737_03865	COG0772	Belongs to the SEDS family
U737_03870	COG2951	lytic endotransglycosylase activity
U737_03885	COG1716	ATPase activity
U737_03905	COG0642	Histidine kinase
U737_03930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
U737_03935	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
U737_03935	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
U737_03950	COG3706	GGDEF domain
U737_03975	COG1131	(ABC) transporter
U737_03980	COG0842	Transport permease protein
U737_03985	COG0842	Transport permease protein
U737_04005	COG0426	domain, Protein
U737_04010	COG0633	Ferredoxin
U737_04040	COG1487	ribonuclease activity
U737_04045	COG4456	Virulence-associated protein
U737_04065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
U737_04085	COG2308	Evidence 4 Homologs of previously reported genes of
U737_04085	COG2307	Protein conserved in bacteria
U737_04090	COG2308	Evidence 4 Homologs of previously reported genes of
U737_04110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
U737_04110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U737_04115	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
U737_04120	COG0045	succinate-CoA ligase (ADP-forming) activity
U737_04140	COG5002	protein histidine kinase activity
U737_04140	COG5001	Diguanylate cyclase
U737_04155	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
U737_04165	COG2890	protein-(glutamine-N5) methyltransferase activity
U737_04170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
U737_04175	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
U737_04185	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
U737_04190	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
U737_04200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
U737_04205	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
U737_04210	COG0193	aminoacyl-tRNA hydrolase activity
U737_04230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
U737_04240	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
U737_04250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
U737_04255	COG0081	regulation of translation
U737_04260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
U737_04265	COG0222	ribosome binding
U737_04270	COG0085	RNA polymerase activity
U737_04275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
U737_04285	COG0049	tRNA binding
U737_04290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
U737_04295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
U737_04300	COG0051	transcription antitermination factor activity, RNA binding
U737_04305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
U737_04310	COG0088	Forms part of the polypeptide exit tunnel
U737_04315	COG0089	rRNA binding
U737_04320	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
U737_04325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
U737_04330	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
U737_04335	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
U737_04340	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
U737_04345	COG0255	Belongs to the universal ribosomal protein uL29 family
U737_04350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
U737_04355	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
U737_04360	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
U737_04375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
U737_04380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
U737_04385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
U737_04390	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
U737_04395	COG1841	ribosomal large subunit assembly
U737_04400	COG0200	Binds to the 23S rRNA
U737_04405	COG0201	protein transport
U737_04410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
U737_04415	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
U737_04420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
U737_04425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
U737_04435	COG0203	ribosomal protein L17
U737_04455	COG2840	Smr protein MutS2
U737_04460	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
U737_04465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
U737_04485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
U737_04490	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
U737_04495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
U737_04495	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
U737_04500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
U737_04505	COG0022	dehydrogenase e1 component
U737_04525	COG1032	radical SAM domain protein
U737_04560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U737_04570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
U737_04575	COG2089	acid synthase
U737_04600	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
U737_04605	COG1516	flagellar protein fliS
U737_04615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
U737_04625	COG4137	Cytochrome C assembly protein
U737_04630	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
U737_04635	COG0228	four-way junction DNA binding
U737_04640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
U737_04645	COG0336	Belongs to the RNA methyltransferase TrmD family
U737_04650	COG0335	large ribosomal subunit rRNA binding
U737_04660	COG4974	Belongs to the 'phage' integrase family
U737_04665	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U737_04680	COG5002	protein histidine kinase activity
U737_04680	COG5001	Diguanylate cyclase
U737_04690	COG1362	aminopeptidase activity
U737_04695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
U737_04700	COG0446	pyridine nucleotide-disulphide oxidoreductase
U737_04765	COG3411	Ferredoxin
U737_04790	COG0247	lactate metabolic process
U737_04795	COG0729	surface antigen
U737_04810	COG1596	polysaccharide export
U737_04815	COG3206	protein involved in exopolysaccharide biosynthesis
U737_04815	COG0489	protein tyrosine kinase activity
U737_04895	COG2815	serine threonine protein kinase
U737_04895	COG0515	serine threonine protein kinase
U737_04945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
U737_04965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U737_04970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U737_04975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U737_04980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
U737_04985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
U737_05000	COG0084	hydrolase, TatD family'
U737_05005	COG2813	Specifically methylates the guanine in position
U737_05010	COG0463	Glycosyl transferase, family 2
U737_05015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U737_05025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
U737_05045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
U737_05050	COG1657	PFAM Prenyltransferase squalene oxidase
U737_05055	COG1562	ergosterol biosynthetic process
U737_05060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
U737_05070	COG2853	Lipoprotein
U737_05075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
U737_05080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
U737_05085	COG0142	geranyltranstransferase activity
U737_05090	COG1722	exodeoxyribonuclease VII activity
U737_05160	COG2918	glutathione biosynthetic process
U737_05165	COG0514	ATP-dependent DNA helicase (RecQ)
U737_05190	COG1434	Gram-negative-bacterium-type cell wall biogenesis
U737_05195	COG1132	(ABC) transporter
U737_05210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
U737_05225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U737_05230	COG0745	RESPONSE REGULATOR receiver
U737_05235	COG0642	Histidine kinase
U737_05240	COG0288	reversible hydration of carbon dioxide
U737_05260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
U737_05265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U737_05285	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
U737_05305	COG2124	cytochrome p450
U737_05335	COG2337	Toxic component of a toxin-antitoxin (TA) module
U737_05350	COG1518	maintenance of DNA repeat elements
U737_05350	COG1468	defense response to virus
U737_05355	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
U737_05360	COG0784	Response regulator, receiver
U737_05360	COG5002	protein histidine kinase activity
U737_05360	COG2205	protein histidine kinase activity
U737_05375	COG0494	nUDIX hydrolase
U737_05385	COG0501	Belongs to the peptidase M48B family
U737_05440	COG1943	Transposase
U737_05445	COG1943	Transposase
U737_05470	COG1595	DNA-templated transcription, initiation
U737_05475	COG0477	Major facilitator Superfamily
U737_05480	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
U737_05490	COG1215	transferase activity, transferring glycosyl groups
U737_05495	COG0038	chloride channel
U737_05500	COG0475	glutathione-regulated potassium exporter activity
U737_05500	COG0569	domain protein
U737_05505	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
U737_05515	COG0561	phosphatase activity
U737_05515	COG3100	YcgL domain-containing protein
U737_05520	COG0438	transferase activity, transferring glycosyl groups
U737_05540	COG0784	Response regulator, receiver
U737_05540	COG2205	protein histidine kinase activity
U737_05540	COG5002	protein histidine kinase activity
U737_05550	COG1902	pentaerythritol trinitrate reductase activity
U737_05555	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
U737_05560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
U737_05565	COG0799	negative regulation of ribosome biogenesis
U737_05580	COG0386	Belongs to the glutathione peroxidase family
U737_05625	COG3585	molybdate ion transport
U737_05625	COG2005	Transcriptional regulator
U737_05655	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
U737_05660	COG0825	malonyl-CoA metabolic process
U737_05665	COG0037	tRNA processing
U737_05685	COG0504	CTP synthase activity
U737_05690	COG2877	3-deoxy-8-phosphooctulonate synthase activity
U737_05695	COG0148	phosphopyruvate hydratase activity
U737_05700	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
U737_05705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
U737_05710	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
U737_05720	COG0585	pseudouridine synthase activity
U737_05740	COG1538	Outer membrane efflux protein
U737_05750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
U737_05755	COG3383	formate dehydrogenase (NAD+) activity
U737_05775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
U737_05785	COG2350	Protein conserved in bacteria
U737_05790	COG2917	probably involved in intracellular septation
U737_05825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
U737_05840	COG1573	uracil-dna glycosylase
U737_05845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
U737_05850	COG1216	Glycosyl transferase, family 2
U737_05870	COG1183	phosphatidylcholine synthase activity
U737_05885	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
U737_05895	COG0028	Belongs to the TPP enzyme family
U737_05900	COG4942	peptidase
U737_05930	COG2091	lysine biosynthetic process via aminoadipic acid
U737_05940	COG2197	response regulator
U737_05945	COG3851	Histidine kinase
U737_05955	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
U737_05960	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
U737_05965	COG2204	response regulator
U737_05970	COG5000	phosphorelay sensor kinase activity
U737_05985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
U737_05990	COG0242	peptide deformylase activity
U737_05995	COG1652	LysM domain
U737_06000	COG0758	DNA mediated transformation
U737_06005	COG2922	Belongs to the Smg family
U737_06025	COG0544	peptidyl-prolyl cis-trans isomerase activity
U737_06030	COG0740	serine-type endopeptidase activity
U737_06035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
U737_06040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
U737_06045	COG0776	regulation of translation
U737_06065	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
U737_06075	COG4174	ABC transporter (Permease)
U737_06080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U737_06105	COG2204	response regulator
U737_06110	COG3852	Histidine kinase
U737_06145	COG3604	Transcriptional regulator
U737_06155	COG3220	belongs to the UPF0276 family
U737_06175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
U737_06180	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
U737_06205	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
U737_06215	COG0659	secondary active sulfate transmembrane transporter activity
U737_06220	COG3002	Belongs to the UPF0753 family
U737_06230	COG0515	serine threonine protein kinase
U737_06230	COG2815	serine threonine protein kinase
U737_06240	COG2223	nitrite transmembrane transporter activity
U737_06245	COG2824	Alkylphosphonate utilization operon protein PhnA
U737_06255	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
U737_06380	COG0629	single-stranded DNA binding
U737_06390	COG3621	Patatin-like phospholipase
U737_06400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
U737_06415	COG4804	nuclease activity
U737_06450	COG0681	Belongs to the peptidase S26 family
U737_06515	COG2963	transposase activity
U737_06525	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U737_06530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U737_06590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
U737_06610	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U737_06745	COG0582	viral genome integration into host DNA
U737_06795	COG0306	phosphate transporter
U737_06800	COG1392	Phosphate transport regulator
U737_06805	COG3976	FMN-binding domain protein
U737_06805	COG1053	succinate dehydrogenase
U737_06805	COG0431	NADPH-dependent FMN reductase
U737_06810	COG4303	Ethanolamine ammonia lyase large subunit
U737_06815	COG4302	ethanolamine ammonia-lyase activity
U737_06830	COG3259	Nickel-dependent hydrogenase
U737_06835	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
U737_06840	COG3383	formate dehydrogenase (NAD+) activity
U737_06845	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
U737_06860	COG0798	PFAM Bile acid sodium symporter
U737_06880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
U737_06895	COG1785	Belongs to the alkaline phosphatase family
U737_06925	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
U737_06935	COG1595	DNA-templated transcription, initiation
U737_06980	COG0495	leucyl-tRNA aminoacylation
U737_06985	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
U737_06990	COG1466	dna polymerase III delta subunit
U737_07000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
U737_07020	COG0415	Belongs to the DNA photolyase family
U737_07030	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
U737_07040	COG0830	nickel cation binding
U737_07045	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
U737_07075	COG0804	urea catabolic process
U737_07080	COG0832	Belongs to the urease beta subunit family
U737_07085	COG0831	urea catabolic process
U737_07100	COG0829	nickel cation binding
U737_07135	COG0559	Belongs to the binding-protein-dependent transport system permease family
U737_07170	COG2205	protein histidine kinase activity
U737_07170	COG0784	Response regulator, receiver
U737_07185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
U737_07190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
U737_07195	COG0416	fatty acid biosynthetic process
U737_07200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
U737_07210	COG0424	maF-like protein
U737_07220	COG0741	lytic transglycosylase activity
U737_07225	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
U737_07230	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
U737_07235	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
U737_07240	COG0302	gtp cyclohydrolase
U737_07245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U737_07265	COG0784	Response regulator, receiver
U737_07265	COG2205	protein histidine kinase activity
U737_07265	COG5002	protein histidine kinase activity
U737_07270	COG3604	Transcriptional regulator
U737_07275	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
U737_07280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U737_07340	COG0281	malic enzyme
U737_07345	COG3104	oligopeptide transport
U737_07350	COG2226	methyltransferase
U737_07365	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
U737_07370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U737_07375	COG0469	pyruvate kinase activity
U737_07380	COG0210	DNA helicase
U737_07390	COG3030	protein affecting phage T7 exclusion by the F plasmid
U737_07395	COG1324	tolerance protein
U737_07400	COG4232	protein-disulfide reductase activity
U737_07405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U737_07410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
U737_07415	COG0511	ligase activity, forming carbon-carbon bonds
U737_07420	COG0439	Biotin carboxylase
U737_07425	COG2264	protein methyltransferase activity
U737_07435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
U737_07460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U737_07510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
U737_07515	COG0700	Nucleoside recognition
U737_07535	COG0482	sulfurtransferase activity
U737_07545	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
U737_07550	COG0542	response to heat
U737_07555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
U737_07560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
U737_07580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
U737_07605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
U737_07670	COG2217	Heavy metal translocating P-type atpase
U737_07710	COG4983	Phage plasmid primase, P4 family domain protein
U737_07725	COG0582	viral genome integration into host DNA
U737_07740	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
U737_07765	COG3852	Histidine kinase
U737_07795	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
U737_07795	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
U737_07795	COG0506	proline dehydrogenase activity
U737_07830	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
U737_07830	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
U737_07835	COG0802	atpase or kinase
U737_07845	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
U737_07850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
U737_07855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
U737_07860	COG0019	diaminopimelate decarboxylase activity
U737_07880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
U737_07885	COG0084	hydrolase, TatD family'
U737_07890	COG0488	(ABC) transporter
U737_07895	COG1923	regulation of RNA biosynthetic process
U737_07900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
U737_07905	COG0330	HflC and HflK could
U737_07910	COG0330	HflC and HflK could
U737_07915	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
U737_07920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
U737_07930	COG0604	alcohol dehydrogenase
U737_07930	COG3321	synthase
U737_07935	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
U737_07970	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U737_07995	COG0360	Binds together with S18 to 16S ribosomal RNA
U737_08000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
U737_08010	COG0359	binds to the 23S rRNA
U737_08015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U737_08055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
U737_08055	COG0574	Belongs to the PEP-utilizing enzyme family
U737_08065	COG1519	Transferase
U737_08070	COG0137	argininosuccinate synthase activity
U737_08085	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
U737_08085	COG1648	precorrin-2 dehydrogenase activity
U737_08090	COG0425	Belongs to the sulfur carrier protein TusA family
U737_08100	COG0494	nUDIX hydrolase
U737_08105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
U737_08110	COG1051	belongs to the nudix hydrolase family
U737_08115	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
U737_08115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
U737_08130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
U737_08135	COG0129	dihydroxy-acid dehydratase activity
U737_08145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
U737_08150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
U737_08165	COG2376	Dihydroxyacetone kinase
U737_08170	COG0647	UMP catabolic process
U737_08185	COG0779	Required for maturation of 30S ribosomal subunits
U737_08190	COG0195	Participates in both transcription termination and antitermination
U737_08195	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
U737_08205	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
U737_08210	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
U737_08215	COG1185	polyribonucleotide nucleotidyltransferase activity
U737_08225	COG2153	protein acetylation
U737_08235	COG1573	uracil-dna glycosylase
U737_08240	COG0322	excinuclease ABC activity
U737_08245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
U737_08255	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
U737_08265	COG3119	arylsulfatase activity
U737_08280	COG0726	polysaccharide deacetylase
U737_08285	COG1959	2 iron, 2 sulfur cluster binding
U737_08290	COG0719	Fe-S assembly protein
U737_08300	COG0396	ATPase activity
U737_08305	COG0719	Fe-S assembly protein
U737_08315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
U737_08325	COG0742	ribosomal rna small subunit methyltransferase
U737_08335	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
U737_08340	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
U737_08355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
U737_08370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
U737_08375	COG2515	1-aminocyclopropane-1-carboxylate deaminase
U737_08385	COG3360	Dodecin
U737_08390	COG0352	thiamine-phosphate diphosphorylase activity
U737_08395	COG0351	phosphomethylpyrimidine kinase
U737_08400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
U737_08405	COG0735	belongs to the Fur family
U737_08410	COG5001	Diguanylate cyclase
U737_08410	COG2203	Gaf domain
U737_08410	COG3706	GGDEF domain
U737_08410	COG4251	negative regulation of phosphorylation
U737_08415	COG0574	Belongs to the PEP-utilizing enzyme family
U737_08415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
U737_08420	COG2081	HI0933 family
U737_08430	COG0372	Belongs to the citrate synthase family
U737_08445	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
U737_08450	COG1053	succinate dehydrogenase
U737_08455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
U737_08460	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
U737_08465	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
U737_08500	COG0745	RESPONSE REGULATOR receiver
U737_08505	COG0643	Histidine kinase
U737_08505	COG2198	Histidine kinase
U737_08515	COG0840	transmembrane signaling receptor activity
U737_08515	COG0840	transmembrane signaling receptor activity
U737_08520	COG0835	chemotaxis
U737_08525	COG1192	Involved in chromosome partitioning
U737_08535	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
U737_08540	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
U737_08545	COG2201	protein-glutamate methylesterase activity
U737_08550	COG0840	transmembrane signaling receptor activity
U737_08565	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
U737_08580	COG1199	ATP-dependent helicase activity
U737_08585	COG1214	PFAM Peptidase M22, glycoprotease
U737_08590	COG0009	L-threonylcarbamoyladenylate synthase
U737_08595	COG1994	Peptidase M50
U737_08605	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
U737_08610	COG1187	pseudouridine synthase activity
U737_08620	COG1943	Transposase
U737_08625	COG0587	DNA-directed DNA polymerase activity
U737_08640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
U737_08645	COG0745	RESPONSE REGULATOR receiver
U737_08670	COG1546	Belongs to the CinA family
U737_08670	COG1058	Belongs to the CinA family
U737_08675	COG0488	(ABC) transporter
U737_08715	COG1943	Transposase
U737_08745	COG3031	protein transport across the cell outer membrane
U737_08775	COG2165	general secretion pathway protein
U737_08810	COG2831	hemolysin activation secretion protein
U737_08820	COG0811	peptide transport
U737_08880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U737_08885	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
U737_08890	COG3123	guanosine phosphorylase activity
U737_08900	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U737_08905	COG0735	belongs to the Fur family
U737_08915	COG1136	(ABC) transporter
U737_08930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
U737_08940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
U737_08945	COG0039	L-malate dehydrogenase activity
U737_08955	COG1216	Glycosyl transferase, family 2
U737_08965	COG0463	Glycosyl transferase, family 2
U737_08970	COG0463	Glycosyl transferase, family 2
U737_08970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
U737_08975	COG3754	Rhamnan synthesis protein F
U737_08980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
U737_09005	COG1216	Glycosyl transferase, family 2
U737_09020	COG3328	transposase activity
U737_09040	COG4536	flavin adenine dinucleotide binding
U737_09050	COG1473	amidohydrolase
U737_09065	COG1450	Type ii and iii secretion system protein
U737_09080	COG3166	PFAM Fimbrial assembly family protein
U737_09085	COG3156	type II secretion system protein K
U737_09095	COG2165	general secretion pathway protein
U737_09110	COG1459	type II secretion system
U737_09120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
U737_09130	COG0232	Belongs to the dGTPase family. Type 2 subfamily
U737_09165	COG3040	lipid binding
U737_09170	COG0415	Belongs to the DNA photolyase family
U737_09180	COG1090	epimerase
U737_09185	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
U737_09200	COG1366	Belongs to the anti-sigma-factor antagonist family
U737_09200	COG2202	Pas domain
U737_09220	COG0330	HflC and HflK could
U737_09225	COG0330	HflC and HflK could
U737_09230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
U737_09260	COG4628	conserved protein (DUF2132)
U737_09275	COG2132	Multicopper oxidase
U737_09285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
U737_09300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U737_09305	COG2072	flavoprotein involved in K transport
U737_09320	COG2144	transferase activity, transferring acyl groups
U737_09355	COG4774	siderophore transport
U737_09360	COG2223	nitrite transmembrane transporter activity
U737_09395	COG1490	D-aminoacyl-tRNA deacylase activity
U737_09410	COG1047	Peptidyl-prolyl cis-trans
U737_09435	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
U737_09440	COG0583	DNA-binding transcription factor activity
U737_09445	COG1472	Belongs to the glycosyl hydrolase 3 family
U737_09455	COG2201	protein-glutamate methylesterase activity
U737_09460	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
U737_09485	COG0643	Histidine kinase
U737_09485	COG2198	Histidine kinase
U737_09490	COG0840	transmembrane signaling receptor activity
U737_09495	COG0835	chemotaxis
U737_09500	COG2703	oxygen carrier activity
U737_09505	COG0840	transmembrane signaling receptor activity
U737_09510	COG2759	Belongs to the formate--tetrahydrofolate ligase family
U737_09515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
U737_09520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
U737_09575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
U737_09580	COG1459	type II secretion system
U737_09595	COG3001	Fructosamine kinase
U737_09615	COG0582	viral genome integration into host DNA
U737_09735	COG3256	nitric oxide reductase
U737_09740	COG2010	Cytochrome c
U737_09750	COG1959	2 iron, 2 sulfur cluster binding
U737_09755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U737_09760	COG0508	dehydrogenase complex catalyzes the overall conversion of
U737_09795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
U737_09815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U737_09850	COG4191	Histidine kinase
U737_09870	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
U737_09875	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
U737_09880	COG5001	Diguanylate cyclase
U737_09880	COG3706	GGDEF domain
U737_09880	COG4251	negative regulation of phosphorylation
U737_09880	COG2203	Gaf domain
U737_09890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U737_09920	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
U737_09925	COG1472	Belongs to the glycosyl hydrolase 3 family
U737_09960	COG2894	cell division
U737_09970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
U737_09975	COG0156	8-amino-7-oxononanoate synthase activity
U737_09980	COG2267	carboxylic ester hydrolase activity
U737_09990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
U737_09995	COG2703	oxygen carrier activity
U737_10005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
U737_10010	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
U737_10035	COG0552	protein localization to endoplasmic reticulum
U737_10040	COG2884	Cell division ATP-binding protein ftsE
U737_10045	COG2177	Part of the ABC transporter FtsEX involved in
U737_10050	COG2983	Belongs to the UPF0260 family
U737_10075	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
U737_10080	COG4260	virion core protein, lumpy skin disease virus
U737_10100	COG3161	chorismate lyase activity
U737_10105	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
U737_10115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
U737_10120	COG1758	RNA polymerase activity
U737_10130	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
U737_10135	COG2923	Belongs to the DsrF TusC family
U737_10145	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
U737_10145	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
U737_10150	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
U737_10190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U737_10255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
U737_10265	COG0045	succinate-CoA ligase (ADP-forming) activity
U737_10270	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
U737_10275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
U737_10290	COG0475	glutathione-regulated potassium exporter activity
U737_10325	COG0659	secondary active sulfate transmembrane transporter activity
U737_10330	COG1649	PFAM Uncharacterised BCR, COG1649
U737_10330	COG0726	polysaccharide deacetylase
U737_10335	COG1215	transferase activity, transferring glycosyl groups
U737_10350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
U737_10360	COG5016	pyruvate
U737_10360	COG0511	ligase activity, forming carbon-carbon bonds
U737_10365	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
U737_10370	COG0438	transferase activity, transferring glycosyl groups
U737_10420	COG1442	glycosyl transferase family 8
U737_10430	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
U737_10445	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
U737_10510	COG3657	addiction module killer protein
U737_10515	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
U737_10565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
U737_10570	COG0037	tRNA processing
U737_10580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
U737_10585	COG0741	lytic transglycosylase activity
U737_10590	COG1132	(ABC) transporter
U737_10595	COG0613	PHP domain protein
U737_10600	COG3300	MHYT domain
U737_10600	COG5001	Diguanylate cyclase
U737_10610	COG5002	protein histidine kinase activity
U737_10610	COG0784	Response regulator, receiver
U737_10610	COG2205	protein histidine kinase activity
U737_10620	COG4771	TonB-dependent receptor
U737_10650	COG0697	spore germination
U737_10655	COG0431	NADPH-dependent FMN reductase
U737_10675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U737_10700	COG4771	TonB-dependent receptor
U737_10750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
U737_10755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U737_10760	COG1045	serine acetyltransferase
U737_10765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
U737_10770	COG0583	DNA-binding transcription factor activity
U737_10775	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
U737_10780	COG4208	sulfate ABC transporter
U737_10785	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
U737_10800	COG5002	protein histidine kinase activity
U737_10800	COG2205	protein histidine kinase activity
U737_10800	COG0784	Response regulator, receiver
U737_10820	COG1116	anion transmembrane transporter activity
U737_10835	COG0439	Biotin carboxylase
U737_10865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U737_10870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U737_10900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
U737_10900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
U737_10905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
U737_10905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
U737_10920	COG0438	transferase activity, transferring glycosyl groups
U737_10930	COG1943	Transposase
U737_11020	COG4232	protein-disulfide reductase activity
U737_11025	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
U737_11040	COG2010	Cytochrome c
U737_11040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
U737_11045	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
U737_11050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U737_11055	COG1535	isochorismatase
U737_11055	COG3433	isochorismatase activity
U737_11060	COG1021	2,3-dihydroxybenzoate-AMP ligase
U737_11065	COG1169	isochorismate synthase
U737_11085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U737_11090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U737_11095	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U737_11110	COG1028	Short-chain dehydrogenase reductase Sdr
U737_11115	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
U737_11120	COG1858	cytochrome C peroxidase
U737_11140	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
U737_11145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
U737_11155	COG0659	secondary active sulfate transmembrane transporter activity
U737_11165	COG0500	methyltransferase
U737_11180	COG1294	oxidase, subunit
U737_11195	COG0446	pyridine nucleotide-disulphide oxidoreductase
U737_11210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U737_11250	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
U737_11255	COG1074	ATP-dependent DNA helicase activity
U737_11260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
U737_11280	COG1538	Outer membrane efflux protein
U737_11300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
U737_11305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
U737_11315	COG0436	Aminotransferase
U737_11320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U737_11330	COG0303	'Molybdopterin
U737_11335	COG1763	Mo-molybdopterin cofactor biosynthetic process
U737_11340	COG0484	heat shock protein binding
U737_11355	COG0248	Ppx GppA phosphatase
U737_11360	COG1131	(ABC) transporter
U737_11365	COG0842	Transport permease protein
U737_11370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U737_11375	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
U737_11390	COG3707	response regulator
U737_11395	COG2223	nitrite transmembrane transporter activity
U737_11400	COG2146	nitrite reductase [NAD(P)H] activity
U737_11400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U737_11405	COG2146	nitrite reductase [NAD(P)H] activity
U737_11410	COG0384	phenazine biosynthesis protein PhzF
U737_11420	COG4452	Inner membrane protein CreD
U737_11440	COG2890	protein-(glutamine-N5) methyltransferase activity
U737_11445	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
U737_11455	COG0811	peptide transport
U737_11465	COG1663	tetraacyldisaccharide 4'-kinase activity
U737_11470	COG2835	tetraacyldisaccharide 4'-kinase activity
U737_11475	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
U737_11505	COG5001	Diguanylate cyclase
U737_11505	COG5002	protein histidine kinase activity
U737_11525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
U737_11535	COG0101	tRNA pseudouridine synthase activity
U737_11540	COG0318	PFAM AMP-dependent synthetase and ligase
U737_11550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U737_11560	COG1028	Short-chain dehydrogenase reductase Sdr
U737_11565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U737_11575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U737_11620	COG1960	acyl-CoA dehydrogenase activity
U737_11645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U737_11690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U737_11715	COG0714	Associated with various cellular activities
U737_11730	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
U737_11765	COG2925	Exonuclease
U737_11770	COG0436	Aminotransferase
U737_11785	COG3550	peptidyl-serine autophosphorylation
U737_11790	COG1396	sequence-specific DNA binding
U737_11805	COG0210	DNA helicase
U737_11840	COG0513	Belongs to the DEAD box helicase family
U737_11850	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
U737_11865	COG1049	propionate catabolic process, 2-methylcitrate cycle
U737_11875	COG0473	3-isopropylmalate dehydrogenase activity
U737_11880	COG4555	ABC transporter
U737_11920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
U737_11945	COG2205	protein histidine kinase activity
U737_11945	COG2198	Histidine kinase
U737_11945	COG0784	Response regulator, receiver
U737_11960	COG1116	anion transmembrane transporter activity
U737_11960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
U737_11965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
U737_11970	COG1116	anion transmembrane transporter activity
U737_11970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
U737_11980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U737_11985	COG0243	molybdopterin cofactor binding
U737_11990	COG4943	cyclic-guanylate-specific phosphodiesterase activity
U737_12025	COG0714	Associated with various cellular activities
U737_12040	COG2010	Cytochrome c
U737_12045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U737_12050	COG4993	Dehydrogenase
U737_12055	COG2197	response regulator
U737_12100	COG1538	Outer membrane efflux protein
U737_12130	COG1595	DNA-templated transcription, initiation
U737_12170	COG3293	Transposase
U737_12180	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
U737_12190	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
U737_12235	COG4644	lycopene metabolic process
U737_12285	COG3657	addiction module killer protein
U737_12295	COG0582	viral genome integration into host DNA
U737_12320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
U737_12330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
U737_12335	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
U737_12355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
U737_12355	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
U737_12360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
U737_12365	COG1196	nuclear chromosome segregation
U737_12365	COG3264	Mechanosensitive ion channel
U737_12395	COG1286	toxin biosynthetic process
U737_12405	COG0285	dihydrofolate synthase activity
U737_12410	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
U737_12415	COG0159	tryptophan synthase activity
U737_12420	COG0133	tryptophan synthase activity
U737_12425	COG0135	phosphoribosylanthranilate isomerase activity
U737_12435	COG1477	protein flavinylation
U737_12445	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
U737_12450	COG0733	neurotransmitter:sodium symporter activity
U737_12455	COG2867	negative regulation of translational initiation
U737_12460	COG2914	Belongs to the UPF0125 (RnfH) family
U737_12495	COG3153	acetyltransferase
U737_12495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U737_12500	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
U737_12505	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
U737_12520	COG1222	aaa ATPase
U737_12580	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
U737_12600	COG2329	Antibiotic biosynthesis monooxygenase
U737_12635	COG0671	phosphoesterase, PA-phosphatase related
U737_12640	COG0456	acetyltransferase
U737_12645	COG2808	Putative FMN-binding domain
U737_12660	COG0504	CTP synthase activity
U737_12675	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
U737_12745	COG0431	NADPH-dependent FMN reductase
U737_12750	COG2197	response regulator
U737_12780	COG5002	protein histidine kinase activity
U737_12790	COG4319	ketosteroid isomerase
U737_12800	COG3070	regulator of competence-specific genes
U737_12875	COG3547	Transposase (IS116 IS110 IS902 family)
U737_12900	COG0583	DNA-binding transcription factor activity
U737_12935	COG0306	phosphate transporter
U737_12940	COG2226	methyltransferase
U737_12970	COG0492	ferredoxin-NADP+ reductase activity
U737_12975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
U737_12990	COG2199	diguanylate cyclase activity
U737_12990	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
U737_13005	COG3220	belongs to the UPF0276 family
U737_13040	COG0789	Transcriptional regulator
U737_13075	COG1942	4-Oxalocrotonate Tautomerase
U737_13080	COG1335	isochorismatase
U737_13095	COG0583	DNA-binding transcription factor activity
U737_13110	COG0625	glutathione transferase activity
U737_13170	COG0681	Belongs to the peptidase S26 family
U737_13330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
U737_13330	COG1648	precorrin-2 dehydrogenase activity
U737_13365	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
U737_13435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
U737_13440	COG2205	protein histidine kinase activity
U737_13440	COG0784	Response regulator, receiver
U737_13440	COG5002	protein histidine kinase activity
U737_13455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
U737_13465	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
U737_13470	COG0575	Belongs to the CDS family
U737_13475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
U737_13480	COG0233	cytoplasmic translational termination
U737_13485	COG0528	UMP kinase activity
U737_13490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
U737_13495	COG0052	Belongs to the universal ribosomal protein uS2 family
U737_13500	COG0024	Methionine aminopeptidase
U737_13505	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
U737_13510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U737_13515	COG0067	glutamate synthase
U737_13515	COG0069	glutamate synthase activity
U737_13515	COG0070	glutamate synthase
U737_13520	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
U737_13545	COG1704	LemA family
U737_13560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
U737_13570	COG0556	nucleotide-excision repair
U737_13650	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
U737_13660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
U737_13660	COG3008	intermembrane lipid transfer
U737_13665	COG1127	ABC transporter
U737_13670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
U737_13685	COG0629	single-stranded DNA binding
U737_13690	COG2814	Major facilitator Superfamily
U737_13700	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
U737_13750	COG0012	GTP binding
U737_13765	COG3706	GGDEF domain
U737_13780	COG0354	folic acid binding
U737_13835	COG4771	TonB-dependent receptor
U737_13860	COG0840	transmembrane signaling receptor activity
U737_13890	COG0165	Argininosuccinate lyase
U737_13920	COG0204	Acyl-transferase
U737_13920	COG0318	PFAM AMP-dependent synthetase and ligase
U737_13930	COG2814	Major facilitator Superfamily
U737_13940	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
U737_13960	COG1570	exodeoxyribonuclease VII activity
U737_13980	COG2871	sodium ion transport
U737_13985	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
U737_13990	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
U737_14015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
U737_14025	COG2833	Protein of unknown function (DUF455)
U737_14085	COG0072	phenylalanine-tRNA ligase activity
U737_14085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U737_14090	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
U737_14095	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
U737_14100	COG0291	Belongs to the bacterial ribosomal protein bL35 family
U737_14105	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
U737_14110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
U737_14130	COG0408	coproporphyrinogen oxidase activity
U737_14135	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
U737_14160	COG1404	Belongs to the peptidase S8 family
U737_14180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
U737_14185	COG1132	(ABC) transporter
U737_14195	COG0588	phosphoglycerate mutase activity
U737_14215	COG0438	transferase activity, transferring glycosyl groups
U737_14245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
U737_14265	COG1643	Atp-dependent helicase
U737_14290	COG3848	Pyruvate phosphate dikinase
U737_14290	COG0574	Belongs to the PEP-utilizing enzyme family
U737_14305	COG0515	serine threonine protein kinase
U737_14305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
U737_14310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
U737_14310	COG0515	serine threonine protein kinase
U737_14375	COG0473	3-isopropylmalate dehydrogenase activity
U737_14380	COG1966	Carbon starvation protein
U737_14390	COG0123	including yeast histone deacetylase and acetoin utilization protein
U737_14395	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
U737_14405	COG1131	(ABC) transporter
U737_14425	COG0686	Belongs to the AlaDH PNT family
U737_14450	COG1138	Cytochrome C-type biogenesis protein
U737_14455	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
U737_14475	COG4133	protoheme IX ABC transporter activity
U737_14490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
U737_14505	COG0776	regulation of translation
U737_14515	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
U737_14520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
U737_14525	COG0287	Prephenate dehydrogenase
U737_14530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
U737_14540	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
U737_14565	COG1639	'signal transduction protein
U737_14575	COG3851	Histidine kinase
U737_14590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
U737_14605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
U737_14615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
U737_14625	COG0436	Aminotransferase
U737_14645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U737_14660	COG0583	DNA-binding transcription factor activity
U737_14695	COG3287	FIST C domain
U737_14695	COG2200	EAL domain
U737_14695	COG2199	diguanylate cyclase activity
U737_14715	COG1295	ribonuclease BN
U737_14745	COG1132	(ABC) transporter
U737_14760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
U737_14765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
U737_14805	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
U737_14815	COG0189	ligase activity
U737_14820	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
U737_14825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
U737_14915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U737_14990	COG0776	regulation of translation
U737_15035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
U737_15050	COG0776	regulation of translation
U737_15105	COG0681	Belongs to the peptidase S26 family
U737_15195	COG0514	ATP-dependent DNA helicase (RecQ)
U737_15200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
U737_15205	COG0720	synthase
U737_15210	COG0602	queuosine metabolic process
U737_15215	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
U737_15330	COG3177	Filamentation induced by cAMP protein fic
U737_15345	COG1872	DUF167
U737_15390	COG3706	GGDEF domain
U737_15395	COG1301	dicarboxylic acid transport
U737_15400	COG3012	SEC-C Motif Domain Protein
U737_15405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
U737_15410	COG0058	SHG alpha-glucan phosphorylase activity
U737_15415	COG0653	protein targeting
U737_15425	COG0569	domain protein
U737_15445	COG3622	Belongs to the hyi family
U737_15450	COG2084	Dehydrogenase
U737_15470	COG1730	sister chromatid segregation
U737_15475	COG2827	Endonuclease containing a URI domain
U737_15485	COG0328	RNA-DNA hybrid ribonuclease activity
U737_15490	COG2226	methyltransferase
U737_15495	COG1388	LysM domain
U737_15495	COG0741	lytic transglycosylase activity
U737_15515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
U737_15545	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U737_15550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
U737_15560	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U737_15565	COG0446	pyridine nucleotide-disulphide oxidoreductase
U737_15570	COG2863	cytochrome
U737_15575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
U737_15580	COG0557	exoribonuclease II activity
U737_15615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U737_15620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
U737_15625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
U737_15630	COG0826	peptidase U32
U737_15640	COG1215	transferase activity, transferring glycosyl groups
U737_15655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
U737_15680	COG4106	trans-aconitate 2-methyltransferase activity
U737_15685	COG2226	methyltransferase
U737_15725	COG0463	Glycosyl transferase, family 2
U737_15745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
U737_15760	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
U737_15780	COG1091	dTDP-4-dehydrorhamnose reductase activity
U737_15800	COG0326	Molecular chaperone. Has ATPase activity
U737_15815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
U737_15820	COG0497	DNA recombination
U737_15825	COG0697	spore germination
U737_15830	COG0840	transmembrane signaling receptor activity
U737_15870	COG0583	DNA-binding transcription factor activity
U737_15875	COG1741	Belongs to the pirin family
U737_15895	COG1574	metal-dependent hydrolase with the TIM-barrel fold
U737_15905	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
U737_15905	COG3264	Mechanosensitive ion channel
U737_15920	COG1104	cysteine desulfurase activity
U737_15935	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
U737_15940	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
U737_15945	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
U737_15950	COG2205	protein histidine kinase activity
U737_15955	COG0745	RESPONSE REGULATOR receiver
U737_15965	COG2151	metal-sulfur cluster biosynthetic enzyme
U737_15980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
U737_15985	COG0402	S-adenosylhomocysteine deaminase activity
U737_15990	COG2204	response regulator
U737_15995	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
U737_16000	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
U737_16080	COG0583	DNA-binding transcription factor activity
U737_16085	COG0784	Response regulator, receiver
U737_16085	COG2198	Histidine kinase
U737_16085	COG2205	protein histidine kinase activity
U737_16130	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
U737_16130	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
U737_16130	COG1013	pyruvate-flavodoxin oxidoreductase activity
U737_16130	COG0674	pyruvate-flavodoxin oxidoreductase activity
U737_16180	COG0330	HflC and HflK could
U737_16185	COG0330	HflC and HflK could
U737_16195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
U737_16210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
U737_16230	COG2853	Lipoprotein
U737_16235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
U737_16240	COG0217	transcriptional regulatory protein
U737_16265	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
U737_16270	COG0583	DNA-binding transcription factor activity
U737_16280	COG4256	Hemin uptake protein
U737_16315	COG3720	iron ion transport
U737_16320	COG0748	coenzyme F420 binding
U737_16325	COG4558	Periplasmic binding protein
U737_16330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U737_16335	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
U737_16385	COG0612	Peptidase, M16
U737_16405	COG4774	siderophore transport
U737_16415	COG3128	pkhd-type hydroxylase
U737_16420	COG4206	TonB-dependent receptor
U737_16440	COG2205	protein histidine kinase activity
U737_16440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U737_16475	COG2200	EAL domain
U737_16485	COG1355	regulation of microtubule-based process
U737_16490	COG3885	ferrous iron binding
U737_16490	COG2078	PFAM AMMECR1 domain protein
U737_16495	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
U737_16500	COG0363	glucosamine-6-phosphate deaminase activity
U737_16510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
U737_16515	COG0800	Aldolase
U737_16520	COG3038	cytochrome b561
U737_16530	COG0501	Belongs to the peptidase M48B family
U737_16540	COG0840	transmembrane signaling receptor activity
U737_16550	COG3852	Histidine kinase
U737_16555	COG2204	response regulator
U737_16560	COG5001	Diguanylate cyclase
U737_16565	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
U737_16580	COG0483	inositol monophosphate 1-phosphatase activity
U737_16585	COG0004	ammonium transporteR
U737_16595	COG0004	ammonium transporteR
U737_16610	COG0174	glutamine synthetase
U737_16620	COG1760	l-serine dehydratase
U737_16635	COG2346	COG2346, Truncated hemoglobins
U737_16650	COG1451	nucleotide metabolic process
U737_16655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U737_16670	COG0280	phosphate acetyltransferase
U737_16670	COG0857	belongs to the CobB CobQ family
U737_16680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
U737_16710	COG1229	Formylmethanofuran dehydrogenase subunit A
U737_16715	COG1469	GTP cyclohydrolase I activity
U737_16720	COG0523	cobalamin synthesis protein
U737_16730	COG2193	ferroxidase activity
U737_16750	COG0745	RESPONSE REGULATOR receiver
U737_16755	COG3437	response regulator, receiver
U737_16760	COG0343	queuine tRNA-ribosyltransferase activity
U737_16765	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U737_16775	COG0673	inositol 2-dehydrogenase activity
U737_16805	COG2217	Heavy metal translocating P-type atpase
U737_16815	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
U737_16825	COG2915	High frequency lysogenization protein hflD homolog
U737_16830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
U737_16855	COG0628	permease
U737_16860	COG0586	Pfam SNARE associated Golgi protein
U737_16865	COG1278	Cold shock
U737_16920	COG1674	ftsk spoiiie
U737_16925	COG0492	ferredoxin-NADP+ reductase activity
U737_16935	COG1136	(ABC) transporter
U737_16945	COG4251	negative regulation of phosphorylation
U737_16950	COG4251	negative regulation of phosphorylation
U737_16955	COG0784	Response regulator, receiver
U737_17020	COG0513	Belongs to the DEAD box helicase family
U737_17045	COG3108	Peptidase M15
U737_17065	COG0442	prolyl-tRNA aminoacylation
U737_17075	COG0702	epimerase
U737_17080	COG0702	epimerase
U737_17100	COG1959	2 iron, 2 sulfur cluster binding
U737_17105	COG1104	cysteine desulfurase activity
U737_17120	COG0242	peptide deformylase activity
U737_17170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
U737_17180	COG1846	Transcriptional regulator
U737_17190	COG1566	PFAM secretion protein HlyD family protein
U737_17225	COG1595	DNA-templated transcription, initiation
U737_17235	COG0488	(ABC) transporter
U737_17280	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
U737_17285	COG2116	formate transmembrane transporter activity
U737_17295	COG0754	glutathionylspermidine amidase activity
U737_17305	COG0745	RESPONSE REGULATOR receiver
U737_17310	COG2205	protein histidine kinase activity
U737_17340	COG2197	response regulator
U737_17355	COG1063	alcohol dehydrogenase
U737_17360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
U737_17380	COG2119	membrane
U737_17390	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
U737_17395	COG4772	TonB-dependent receptor
U737_17405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
U737_17410	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
U737_17415	COG3178	'Phosphotransferase
U737_17420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
U737_17425	COG1981	membrane
U737_17440	COG0463	Glycosyl transferase, family 2
U737_17450	COG0418	dihydroorotase activity
U737_17460	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
U737_17470	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
U737_17475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
U737_17480	COG1509	lysine 2,3-aminomutase activity
U737_17490	COG2203	Gaf domain
U737_17490	COG4251	negative regulation of phosphorylation
U737_17490	COG5001	Diguanylate cyclase
U737_17490	COG3706	GGDEF domain
U737_17500	COG2204	response regulator
U737_17510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
U737_17515	COG1381	Involved in DNA repair and RecF pathway recombination
U737_17520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
U737_17525	COG0571	ribonuclease III activity
U737_17535	COG0681	Belongs to the peptidase S26 family
U737_17540	COG0481	GTPase activity
U737_17550	COG1196	nuclear chromosome segregation
U737_17555	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
U737_17560	COG2205	protein histidine kinase activity
U737_17565	COG0745	RESPONSE REGULATOR receiver
U737_17575	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
U737_17585	COG0688	phosphatidylethanolamine metabolic process
U737_17590	COG1862	Preprotein translocase
U737_17595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U737_17600	COG0105	UTP biosynthetic process
U737_17605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
U737_17615	COG0124	histidyl-tRNA synthetase
U737_17625	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U737_17630	COG1160	GTP binding
U737_17635	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
U737_17665	COG5001	Diguanylate cyclase
U737_17665	COG3447	MASE1 domain protein
U737_17665	COG5002	protein histidine kinase activity
U737_17675	COG4191	Histidine kinase
U737_17680	COG4566	intracellular signal transduction
U737_17690	COG1525	nuclease
U737_17700	COG5002	protein histidine kinase activity
U737_17700	COG2205	protein histidine kinase activity
U737_17700	COG0784	Response regulator, receiver
U737_17705	COG3437	response regulator, receiver
U737_17730	COG0513	Belongs to the DEAD box helicase family
U737_17740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
U737_17745	COG2816	NAD+ diphosphatase activity
U737_17750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
U737_17755	COG0484	heat shock protein binding
U737_17775	COG0443	Heat shock 70 kDa protein
U737_17780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
U737_17785	COG1420	regulation of RNA biosynthetic process
U737_17795	COG4771	TonB-dependent receptor
U737_17800	COG1429	ligase activity, forming nitrogen-metal bonds
U737_17830	COG0864	Transcriptional regulator
U737_17895	COG2204	response regulator
U737_17900	COG4191	Histidine kinase
U737_17905	COG1858	cytochrome C peroxidase
U737_17920	COG0732	type I restriction modification DNA specificity domain
U737_18020	COG0582	viral genome integration into host DNA
U737_18035	COG0149	triose-phosphate isomerase activity
U737_18040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
U737_18060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
U737_18065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
U737_18070	COG0505	Belongs to the CarA family
U737_18080	COG0745	RESPONSE REGULATOR receiver
U737_18085	COG2205	protein histidine kinase activity
U737_18110	COG0569	domain protein
U737_18110	COG2985	domain, Protein
U737_18140	COG0746	molybdenum cofactor guanylyltransferase activity
U737_18170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
U737_18175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
U737_18180	COG2863	cytochrome
U737_18210	COG2914	Belongs to the UPF0125 (RnfH) family
U737_18225	COG4658	electron transport chain
U737_18230	COG4656	Part of a membrane complex involved in electron transport
U737_18235	COG2878	Part of a membrane complex involved in electron transport
U737_18240	COG4657	Part of a membrane complex involved in electron transport
U737_18255	COG3404	Formiminotransferase-cyclodeaminase
U737_18260	COG0215	cysteine-tRNA ligase activity
U737_18270	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U737_18280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
U737_18295	COG3320	Male sterility
U737_18295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U737_18315	COG2801	Transposase and inactivated derivatives
U737_18355	COG0529	Catalyzes the synthesis of activated sulfate
U737_18360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U737_18365	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
U737_18370	COG0138	bifunctional purine biosynthesis protein purh
U737_18380	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
U737_18395	COG2183	response to ionizing radiation
U737_18405	COG0419	ATPase involved in DNA repair
U737_18420	COG0367	asparagine synthase
U737_18425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U737_18430	COG0438	transferase activity, transferring glycosyl groups
U737_18435	COG0438	transferase activity, transferring glycosyl groups
U737_18455	COG0367	asparagine synthase
U737_18460	COG0438	transferase activity, transferring glycosyl groups
U737_18495	COG0489	protein tyrosine kinase activity
U737_18525	COG4191	Histidine kinase
U737_18530	COG2204	response regulator
U737_18555	COG2308	Evidence 4 Homologs of previously reported genes of
U737_18570	COG1566	PFAM secretion protein HlyD family protein
U737_18575	COG1538	Outer membrane efflux protein
U737_18590	COG0583	DNA-binding transcription factor activity
U737_18600	COG2346	COG2346, Truncated hemoglobins
U737_18610	COG1686	Belongs to the peptidase S11 family
U737_18620	COG2921	Belongs to the UPF0250 family
U737_18625	COG0321	lipoyl(octanoyl) transferase activity
U737_18630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
U737_18640	COG2909	trisaccharide binding
U737_18680	COG0653	protein targeting
U737_18710	COG3706	GGDEF domain
U737_18715	COG3550	peptidyl-serine autophosphorylation
U737_18775	COG0582	viral genome integration into host DNA
U737_18785	COG3436	PFAM IS66 Orf2 family protein
U737_18835	COG3609	addiction module antidote protein, CC2985 family
U737_18875	COG2189	Belongs to the N(4) N(6)-methyltransferase family
U737_18890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
U737_18900	COG3328	transposase activity
U737_18925	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
U737_18940	COG0582	viral genome integration into host DNA
U737_18995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U737_19000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
U737_19005	COG2135	peptidase activity
U737_19090	COG0582	viral genome integration into host DNA
U737_19105	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
U737_19175	COG1543	Belongs to the glycosyl hydrolase 57 family
U737_19205	COG0126	phosphoglycerate kinase activity
U737_19215	COG1943	Transposase
U737_19240	COG1595	DNA-templated transcription, initiation
U737_19265	COG1686	Belongs to the peptidase S11 family
U737_19270	COG2900	Belongs to the SlyX family
U737_19285	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
U737_19290	COG0590	tRNA wobble adenosine to inosine editing
U737_19300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
U737_19305	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
U737_19315	COG2226	methyltransferase
U737_19330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
U737_19355	COG3267	Type II secretory pathway component ExeA
U737_19355	COG3409	Peptidoglycan-binding domain 1 protein
U737_19375	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
U737_19400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U737_19405	COG1136	(ABC) transporter
U737_19405	COG0577	efflux transmembrane transporter activity
U737_19420	COG1943	Transposase
U737_19425	COG1573	uracil-dna glycosylase
U737_19430	COG0708	Exodeoxyribonuclease III
U737_19435	COG0531	amino acid
U737_19465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
U737_19465	COG0116	Belongs to the methyltransferase superfamily
U737_19470	COG3384	dioxygenase
U737_19480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
U737_19495	COG0659	secondary active sulfate transmembrane transporter activity
U737_19500	COG0288	reversible hydration of carbon dioxide
U737_19515	COG0483	inositol monophosphate 1-phosphatase activity
U737_19550	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
U737_19555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
U737_19580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
U737_19585	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
U737_19590	COG0297	glycogen (starch) synthase activity
U737_19600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
U737_19610	COG4535	Mg2 and Co2 transporter CorC
U737_19620	COG1702	phosphate starvation-inducible protein PhoH
U737_19625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
U737_19640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
U737_19645	COG0602	queuosine metabolic process
U737_19650	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
U737_19655	COG2885	chlorophyll binding
U737_19660	COG0823	Involved in the tonB-independent uptake of proteins
U737_19680	COG0824	Thioesterase
U737_19690	COG0632	four-way junction helicase activity
U737_19695	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
U737_19700	COG0217	transcriptional regulatory protein
U737_19710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
U737_19745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
U737_19755	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
U737_19760	COG0316	Belongs to the HesB IscA family
U737_19770	COG0535	radical SAM domain protein
U737_19810	COG2863	cytochrome
U737_19815	COG2010	Cytochrome c
U737_19825	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
U737_19830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
U737_19835	COG0563	adenylate kinase activity
U737_19840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
U737_19845	COG0066	3-isopropylmalate dehydratase activity
U737_19850	COG0473	3-isopropylmalate dehydrogenase activity
U737_19855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
U737_19945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
U737_19975	COG0784	Response regulator, receiver
U737_19975	COG0835	chemotaxis
U737_19980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
U737_19985	COG1815	bacterial-type flagellum-dependent cell motility
U737_19990	COG1558	bacterial-type flagellum-dependent cell motility
U737_19995	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
U737_20000	COG1749	Flagellar hook protein flgE
U737_20005	COG4787	bacterial-type flagellum-dependent cell motility
U737_20010	COG4786	Flagellar basal body rod
U737_20015	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
U737_20020	COG1706	bacterial-type flagellum-dependent cell motility
U737_20025	COG3951	Flagellar rod assembly protein muramidase FlgJ
U737_20025	COG1705	Flagellar rod assembly protein muramidase FlgJ
U737_20035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
U737_20085	COG5002	protein histidine kinase activity
U737_20090	COG0745	RESPONSE REGULATOR receiver
U737_20095	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
U737_20100	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
U737_20105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
U737_20190	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
U737_20205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U737_20210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U737_20230	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
U737_20235	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
U737_20305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
U737_20325	COG3079	Belongs to the UPF0149 family
U737_20330	COG0006	proline dipeptidase activity
U737_20335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U737_20385	COG1595	DNA-templated transcription, initiation
U737_20405	COG1253	flavin adenine dinucleotide binding
U737_20415	COG3086	response to oxidative stress
U737_20430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
U737_20465	COG3240	lipase activity
U737_20505	COG4771	TonB-dependent receptor
U737_20525	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
U737_20530	COG0706	membrane insertase activity
U737_20540	COG0594	ribonuclease P activity
U737_20545	COG0230	Belongs to the bacterial ribosomal protein bL34 family
U737_20555	COG0306	phosphate transporter
U737_20565	COG0625	glutathione transferase activity
U737_20570	COG2969	positive regulation of protein catabolic process
U737_20575	COG2154	pterin-4-alpha-carbinolamine dehydratase
U737_20585	COG1229	Formylmethanofuran dehydrogenase subunit A
U737_20590	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
U737_20615	COG1278	Cold shock
U737_20620	COG0542	response to heat
U737_20640	COG0268	Binds directly to 16S ribosomal RNA
U737_20645	COG0728	peptidoglycan biosynthetic process
U737_20665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
U737_20675	COG0756	dUTP diphosphatase activity
U737_20680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
U737_20690	COG0741	lytic transglycosylase activity
U737_20700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
U737_20715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
U737_20720	COG0305	Participates in initiation and elongation during chromosome replication
U737_20740	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
U737_20755	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U737_20770	COG0309	Hydrogenase expression formation protein (HypE)
U737_20780	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
U737_20785	COG3657	addiction module killer protein
U737_20805	COG0409	Hydrogenase expression formation protein
U737_20830	COG0375	protein maturation
U737_20835	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
U737_20840	COG1773	rubredoxin
U737_20850	COG1773	rubredoxin
U737_20910	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
U737_20930	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
U737_20935	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
U737_20945	COG3956	TIGRFAM MazG family protein
U737_20950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U737_20955	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
U737_20960	COG0509	glycine decarboxylation via glycine cleavage system
U737_20980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
U737_20985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U737_20990	COG0543	2 iron, 2 sulfur cluster binding
U737_20990	COG0493	'glutamate synthase
U737_20995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
U737_21000	COG1278	Cold shock
U737_21005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
U737_21010	COG2920	part of a sulfur-relay system
U737_21025	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
U737_21030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
U737_21060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U737_21085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
U737_21105	COG2346	COG2346, Truncated hemoglobins
U737_21110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
U737_21115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
U737_21120	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
U737_21125	COG0501	Belongs to the peptidase M48B family
U737_21130	COG1162	GTPase activity
U737_21135	COG0022	dehydrogenase e1 component
U737_21140	COG0508	dehydrogenase complex catalyzes the overall conversion of
U737_21160	COG0537	adenosine 5'-monophosphoramidase activity
U737_21165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
U737_21170	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
U737_21175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
U737_21185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
U737_21185	COG0616	signal peptide processing
U737_21190	COG0546	phosphoglycolate phosphatase activity
U737_21195	COG0564	pseudouridine synthase activity
U737_21200	COG1530	ribonuclease E activity
U737_21205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U737_21230	COG1222	aaa ATPase
U737_21330	COG0528	UMP kinase activity
U737_21335	COG0528	UMP kinase activity
U737_21370	COG0811	peptide transport
U737_21415	COG0429	hydrolase of the alpha beta-hydrolase fold
U737_21440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
U737_21450	COG0519	Catalyzes the synthesis of GMP from XMP
U737_21455	COG0748	coenzyme F420 binding
U737_21465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
U737_21480	COG1739	Uncharacterized protein family UPF0029
U737_21485	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
U737_21490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
U737_21500	COG4771	TonB-dependent receptor
U737_21500	COG4771	TonB-dependent receptor
U737_21515	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
U737_21520	COG2894	cell division
U737_21525	COG0850	regulation of cytokinetic process
U737_21530	COG2239	Acts as a magnesium transporter
U737_21535	COG1660	Displays ATPase and GTPase activities
U737_21545	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
U737_21550	COG1137	ATPase activity
U737_21555	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
U737_21575	COG1127	ABC transporter
U737_21580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
U737_21585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
U737_21595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
U737_21600	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
U737_21605	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
U737_21655	COG0583	DNA-binding transcription factor activity
U737_21695	COG4999	Histidine kinase
U737_21695	COG3850	Histidine kinase
U737_21695	COG2205	protein histidine kinase activity
U737_21695	COG3437	response regulator, receiver
U737_21720	COG2132	Multicopper oxidase
U737_21725	COG0730	response to heat
U737_21730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U737_21730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U737_21735	COG2204	response regulator
U737_21745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
U737_21750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
U737_21750	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
U737_21765	COG0356	it plays a direct role in the translocation of protons across the membrane
U737_21785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
U737_21800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
U737_21810	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
U737_21815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
U737_21830	COG0358	DNA primase activity
U737_21840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
U737_21845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
U737_21850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
U737_21855	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
U737_21860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
U737_21910	COG0596	Alpha beta hydrolase
U737_21930	COG0842	Transport permease protein
U737_21935	COG1131	(ABC) transporter
U737_21950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U737_21960	COG1028	Short-chain dehydrogenase reductase Sdr
U737_21985	COG0312	modulator of DNA gyrase
U737_21990	COG0312	modulator of DNA gyrase
U737_22000	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
U737_22010	COG0617	tRNA 3'-terminal CCA addition
U737_22015	COG0730	response to heat
U737_22025	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
U737_22035	COG4636	protein conserved in cyanobacteria
U737_22045	COG0535	radical SAM domain protein
U737_22050	COG1132	(ABC) transporter
U737_22055	COG0859	PFAM glycosyl transferase family 9
U737_22070	COG0463	Glycosyl transferase, family 2
U737_22085	COG0835	chemotaxis
U737_22095	COG1192	Involved in chromosome partitioning
U737_22105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
U737_22115	COG2198	Histidine kinase
U737_22115	COG0643	Histidine kinase
U737_22115	COG0784	Response regulator, receiver
U737_22120	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
U737_22155	COG1684	flagellar biosynthetic protein fliR
U737_22185	COG1580	Controls the rotational direction of flagella during chemotaxis
U737_22195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
U737_22215	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
U737_22225	COG1555	photosystem II stabilization
U737_22230	COG0500	methyltransferase
U737_22235	COG4106	trans-aconitate 2-methyltransferase activity
U737_22240	COG2854	intermembrane phospholipid transfer
U737_22255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
U737_22275	COG0339	signal peptide processing
U737_22390	COG3209	COG3209 Rhs family protein
U737_22405	COG3209	COG3209 Rhs family protein
U737_22495	COG0631	protein serine/threonine phosphatase activity
U737_22580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
U737_22585	COG0019	diaminopimelate decarboxylase activity
U737_22625	COG0254	rRNA binding
U737_22630	COG2223	nitrite transmembrane transporter activity
U737_22635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
U737_22650	COG0793	Belongs to the peptidase S41A family
U737_22655	COG4942	peptidase
U737_22660	COG0640	Transcriptional regulator
U737_22670	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
U737_22675	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
U737_22680	COG2001	Belongs to the MraZ family
U737_22690	COG3116	cell division
U737_22705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
U737_22710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
U737_22715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
U737_22720	COG0772	Belongs to the SEDS family
U737_22725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
U737_22730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
U737_22735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
U737_22740	COG1181	Belongs to the D-alanine--D-alanine ligase family
U737_22745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
U737_22755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
U737_22760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
U737_22780	COG0546	phosphoglycolate phosphatase activity
U737_22780	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
U737_22790	COG0531	amino acid
U737_22820	COG2084	Dehydrogenase
U737_22830	COG1166	arginine decarboxylase activity
U737_22835	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
U737_22870	COG1136	(ABC) transporter
U737_22870	COG0577	efflux transmembrane transporter activity
U737_22905	COG1136	(ABC) transporter
U737_22905	COG0577	efflux transmembrane transporter activity
U737_22920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
U737_22925	COG0795	lipopolysaccharide-transporting ATPase activity
U737_22950	COG0617	tRNA 3'-terminal CCA addition
U737_22960	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
U737_22965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
U737_22970	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
U737_22975	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
U737_22980	COG4206	TonB-dependent receptor
U737_22990	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
U737_23010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
U737_23015	COG2104	thiamine diphosphate biosynthetic process
U737_23015	COG2022	thiamine diphosphate biosynthetic process
U737_23035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
U737_23075	COG3958	Transketolase
U737_23085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
U737_23090	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
U737_23095	COG0792	nuclease activity
U737_23100	COG3107	peptidoglycan biosynthetic process
U737_23105	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
U737_23120	COG2205	protein histidine kinase activity
U737_23120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U737_23130	COG1410	methionine synthase
U737_23130	COG0646	methionine synthase
U737_23155	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
U737_23160	COG0751	glycine-tRNA ligase activity
U737_23165	COG0752	glycyl-tRNA synthetase alpha subunit
U737_23190	COG2373	Large extracellular alpha-helical protein
U737_23235	COG4771	TonB-dependent receptor
U737_23250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
U737_23255	COG0581	inorganic phosphate transmembrane transporter activity
U737_23270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
U737_23275	COG0252	asparaginase activity
U737_23290	COG0018	arginyl-trna synthetase
U737_23300	COG0805	protein transport
U737_23305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U737_23310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U737_23315	COG0140	phosphoribosyl-ATP diphosphatase activity
U737_23320	COG0583	DNA-binding transcription factor activity
U737_23335	COG1217	gtp-binding protein TYPA
U737_23340	COG0730	response to heat
U737_23360	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
U737_23375	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
U737_23380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U737_23380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
U737_23385	COG1056	cytidyltransferase-related domain
U737_23385	COG1051	belongs to the nudix hydrolase family
U737_23390	COG3530	Putative quorum-sensing-regulated virulence factor
U737_23400	COG1902	pentaerythritol trinitrate reductase activity
U737_23425	COG4636	protein conserved in cyanobacteria
U737_23455	COG1252	NADH dehydrogenase
U737_23480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
U737_23480	COG0519	Catalyzes the synthesis of GMP from XMP
U737_23520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U737_23530	COG0791	NLP P60 protein
U737_23535	COG0778	Nitroreductase
U737_23545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
U737_23550	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
U737_23555	COG0589	response to stress
U737_23570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
U737_23575	COG4221	oxidoreductase activity
U737_23600	COG0196	riboflavin kinase activity
U737_23615	COG1309	transcriptional regulator
U737_23620	COG0625	glutathione transferase activity
U737_23640	COG0714	Associated with various cellular activities
U737_23660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
U737_23665	COG2954	triphosphatase activity
U737_23695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
U737_23700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
U737_23705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
U737_23710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
U737_23715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
U737_23720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
U737_23725	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
U737_23730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
U737_23740	COG0356	it plays a direct role in the translocation of protons across the membrane
U737_23750	COG1475	DNA binding
U737_23755	COG1192	Involved in chromosome partitioning
U737_23760	COG0357	Ribosomal RNA small subunit methyltransferase G
U737_23780	COG0445	tRNA wobble uridine modification
U737_23790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
U737_23790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
U737_23795	COG1067	ATP-dependent peptidase activity
U737_23805	COG0745	RESPONSE REGULATOR receiver
U737_23830	COG0443	Heat shock 70 kDa protein
U737_23840	COG0484	heat shock protein binding
U737_23860	COG0656	L-ascorbic acid biosynthetic process
U737_23880	COG3045	CreA protein
U737_23920	COG2169	Transcriptional regulator
U737_23920	COG1917	Cupin 2, conserved barrel domain protein
U737_23925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U737_23935	COG4941	Belongs to the sigma-70 factor family
U737_23960	COG3795	YCII-related domain
U737_23975	COG3795	YCII-related domain
U737_24005	COG1393	Belongs to the ArsC family
U737_24010	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
U737_24010	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
U737_24025	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
U737_24030	COG0037	tRNA processing
U737_24030	COG0590	tRNA wobble adenosine to inosine editing
U737_24055	COG1858	cytochrome C peroxidase
U737_24060	COG1322	Protein conserved in bacteria
U737_24090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity