locus-tag class description U737_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) U737_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) U737_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) U737_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) U737_00075 ENOG4108RAV Conserved protein U737_00155 ENOG4105C4R Atp-dependent dna helicase U737_00160 ENOG4105C0H protease U737_00165 ENOG4108V62 Rhodanese domain protein U737_00170 ENOG4105W0E 50S ribosomal protein L33 U737_00175 ENOG4105KDC 50s ribosomal protein l28 U737_00180 ENOG4105D7Z glutathione synthase U737_00190 ENOG4108UJU UPF0301 protein U737_00195 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) U737_00200 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) U737_00205 ENOG4105CXT aspartate transcarbamylase U737_00210 ENOG4105CD3 dihydroorotase U737_00220 ENOG4105C7R Atpase associated with various cellular activities aaa_3 U737_00230 ENOG4105BZU Histidine kinase U737_00270 ENOG4107RK2 ADP-ribose diphosphatase NudE U737_00275 ENOG4105C8Q Methyl-accepting chemotaxis U737_00280 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 U737_00285 ENOG4105C1J atp-dependent rna helicase U737_00290 ENOG4105K63 Thioredoxin U737_00295 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) U737_00315 ENOG4108ZAF Molybdopterin U737_00320 ENOG4105M00 molybdopterin converting factor, subunit 1 U737_00325 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) U737_00345 ENOG4105C03 ribonuclease U737_00350 ENOG4108Z03 MAF-like protein U737_00355 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) U737_00365 ENOG4105C8S subunit m U737_00375 ENOG4105EVH UPF0753 protein U737_00380 ENOG4105D65 subunit l U737_00385 ENOG4105C8S subunit m U737_00390 ENOG4105C8S subunit m U737_00395 ENOG41077A9 carbonic anhydrase U737_00400 ENOG4105CHH sulfate transporter U737_00420 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) U737_00425 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) U737_00435 ENOG4105DSJ YicC domain protein U737_00450 ENOG4105CHR reductase U737_00475 ENOG4105BZU Histidine kinase U737_00485 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) U737_00490 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) U737_00500 ENOG4106H3A restriction U737_00525 ENOG4105E7Z methane monooxygenase ammonia monooxygenase subunit A U737_00530 ENOG4108P7H monooxygenase, subunit B U737_00545 ENOG4105DCM major facilitator superfamily U737_00580 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) U737_00595 ENOG4105CB2 alcohol dehydrogenase U737_00600 ENOG4105E1F short-chain dehydrogenase reductase U737_00605 ENOG4107YPT transcriptional regulator U737_00610 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) U737_00615 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase U737_00620 ENOG4105GN9 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) U737_00630 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) U737_00635 ENOG4108YZT Adenosylcobinamide kinase U737_00640 ENOG41081QV Universal stress protein U737_00650 ENOG4105C5H ABC transporter U737_00665 ENOG4108IJF Heavy metal efflux pump, CzcA U737_00675 ENOG4105ENJ RND efflux system, outer membrane lipoprotein U737_00685 ENOG4105DK0 Indole-3-glycerol phosphate synthase U737_00700 ENOG4105YES addiction module antidote protein U737_00705 ENOG4105VUH addiction module killer protein U737_00710 ENOG4107QYG anthranilate phosphoribosyltransferase U737_00725 ENOG4105KRQ Addiction module toxin, Txe YoeB family U737_00735 ENOG4105DDQ anthranilate synthase U737_00740 ENOG4105CRQ synthase (Component I) U737_00770 ENOG4108QD4 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) U737_00780 ENOG4107TVJ ,Oxidoreductase FAD NAD(P)-binding U737_00785 ENOG4106CEW U737_00790 ENOG4105J38 Methane monooxygenase U737_00795 ENOG410666X The B protein acts as a regulator of electron flow through the soluble mmo complex, switching the enzyme from an oxidase to a hydroxylase in the presence of the substrate U737_00800 ENOG4105CKQ methane phenol toluene hydroxylase U737_00805 ENOG4105EUX methane phenol toluene hydroxylase U737_00820 ENOG4105DFH Transport of potassium into the cell (By similarity) U737_00825 ENOG4105WQ5 TonB family U737_00835 ENOG4105SG9 biopolymer transport protein, ExbD U737_00840 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) U737_00845 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) U737_00850 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) U737_00855 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) U737_00880 ENOG4107QX8 SPFH domain, Band 7 family protein U737_00890 ENOG4105F8C transglutaminase domain-containing protein U737_00900 ENOG4105C7R Atpase associated with various cellular activities aaa_3 U737_00910 ENOG4105CZX twitching motility protein U737_00915 ENOG4105CZX twitching motility protein U737_00920 ENOG4105CVE Lytic murein transglycosylase U737_00945 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) U737_00950 ENOG4105C2M dna polymerase I U737_00960 ENOG4105E0K tonB-dependent siderophore receptor U737_00990 ENOG4108Z4U Ferredoxin U737_00995 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) U737_01000 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) U737_01005 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) U737_01020 ENOG4105CD5 CoA-binding domain protein U737_01025 ENOG4105E0K tonB-dependent siderophore receptor U737_01045 ENOG4105E0K tonB-dependent siderophore receptor U737_01065 ENOG4105CNM Receptor U737_01070 ENOG4108S3W Anti-feci sigma factor, fecr U737_01085 ENOG4105E0K tonB-dependent siderophore receptor U737_01110 ENOG4105E0K tonB-dependent siderophore receptor U737_01125 ENOG4105E0K tonB-dependent siderophore receptor U737_01130 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase U737_01135 ENOG4105N42 UPF0307 protein U737_01145 ENOG4105DH7 May be involved in recombination (By similarity) U737_01150 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein U737_01165 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 U737_01175 ENOG4105VEQ Cold shock protein U737_01190 ENOG4105CEN a g-specific adenine glycosylase U737_01195 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) U737_01210 ENOG4107QN2 dihydrolipoyl dehydrogenase U737_01235 ENOG4107QSN dihydrolipoamide acetyltransferase U737_01240 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) U737_01255 ENOG4105CNG UPF0061 protein U737_01270 ENOG4105BZU Histidine kinase U737_01275 ENOG4107RGD Major Facilitator superfamily U737_01285 ENOG4105YA8 Transcriptional regulator U737_01305 ENOG4108UKZ OsmC family U737_01310 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) U737_01320 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) U737_01325 ENOG4105NWN ApaG protein U737_01335 ENOG4105DFU Cell wall formation (By similarity) U737_01345 ENOG4105D9P serine threonine protein kinase U737_01360 ENOG410841Q phosphoesterase PA-phosphatase related protein U737_01385 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) U737_01400 ENOG4107RD7 Flagellar Motor Protein, MotA U737_01405 ENOG4105ER2 Ompa motb domain protein U737_01420 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) U737_01435 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme U737_01440 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) U737_01450 ENOG4105D49 3-dehydroquinate synthase U737_01455 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) U737_01460 ENOG4105WDY DNA (cytosine-5-)-methyltransferase U737_01465 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) U737_01470 ENOG4105D3Q Sugar transferase U737_01480 ENOG4108TGC Acyltransferase U737_01495 ENOG4108PQP glycosyl transferase group 1 U737_01520 ENOG4107STW synthase U737_01525 ENOG4105CPK Glycosyl transferase (Group 1 U737_01585 ENOG4105DHQ Histidine kinase U737_01590 ENOG4105XJC Two component transcriptional regulator (Winged helix family U737_01620 ENOG4105W0Z cytoplasmic protein U737_01625 ENOG4105C0P Mg chelatase subunit ChlI U737_01635 ENOG4105D3R alkyl hydroperoxide reductase U737_01645 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase U737_01660 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) U737_01665 ENOG4105CSA Coproporphyrinogen iii oxidase U737_01675 ENOG4105BZU Histidine kinase U737_01680 ENOG4108V3W Chemotaxis protein, CheW U737_01690 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor U737_01695 ENOG4105CBS Chea signal transduction histidine kinase U737_01705 ENOG4107YTP response regulator receiver protein U737_01710 ENOG4105C8Q Methyl-accepting chemotaxis U737_01725 ENOG4105E18 UPF0276 protein U737_01740 ENOG4105CSM endonuclease III U737_01750 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) U737_01765 ENOG4105E1F short-chain dehydrogenase reductase U737_01780 ENOG4105PBF Anti-RNA polymerase sigma 70 factor U737_01785 ENOG4105DJZ UPF0182 protein U737_01805 ENOG4105BZU Histidine kinase U737_01810 ENOG4105BZU Histidine kinase U737_01815 ENOG4108Z33 Thiol disulfide Interchange Protein U737_01825 ENOG4106RE7 Cytochrome U737_01830 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) U737_01850 ENOG4105C8Q Methyl-accepting chemotaxis U737_01860 ENOG4108VYJ response regulator receiver protein U737_01870 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) U737_01890 ENOG4105W39 Membrane U737_01905 ENOG4107QP8 phosphohexose isomerase U737_01950 ENOG4105WH1 Two component transcriptional regulator luxr family U737_01955 ENOG4105BZU Histidine kinase U737_01980 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein U737_01990 ENOG4105CVP deoxyribo-dipyrimidine photolyase U737_02000 ENOG4105C0H protease U737_02010 ENOG4108Z6B deaminase U737_02015 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) U737_02020 ENOG4107QSA Oxaloacetate decarboxylase U737_02025 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase U737_02040 ENOG4105CKK Glycosyl transferase, family 2 U737_02045 ENOG4108UJV acyl-CoA thioesterase i U737_02050 ENOG4108I0Y (ABC) transporter U737_02065 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) U737_02070 ENOG4105DPZ Two component transcriptional regulator (Winged helix family U737_02075 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase U737_02095 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) U737_02105 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 U737_02110 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) U737_02115 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) U737_02130 ENOG4108V1T peptidylprolyl cis-trans isomerase U737_02145 ENOG4107QYG anthranilate phosphoribosyltransferase U737_02150 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) U737_02165 ENOG4106H78 methyltransferase U737_02170 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) U737_02175 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding U737_02180 ENOG4105DQ4 alcohol dehydrogenase U737_02185 ENOG4105BZU Histidine kinase U737_02195 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) U737_02245 ENOG4108VKG metal-dependent hydrolase U737_02250 ENOG4105W87 Cbs domain U737_02260 ENOG4105IPI Membrane U737_02265 ENOG4108RIR Molybdenum cofactor biosynthesis protein U737_02280 ENOG4105CD8 aminopeptidase N U737_02285 ENOG4105ECC imidazole-glycerol-phosphate dehydratase U737_02290 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) U737_02295 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase U737_02300 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) U737_02305 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase U737_02335 ENOG4105DTT CRISPR-associated helicase, cas3 U737_02340 ENOG41071TK Uncharacterised protein family (UPF0150) U737_02365 ENOG4108VWQ crispr-associated protein U737_02385 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) U737_02390 ENOG4105PWE CRISPR-associated protein cas2 U737_02405 ENOG4108R3D Electron transport complex U737_02410 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) U737_02430 ENOG4105BZU Histidine kinase U737_02435 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein U737_02440 ENOG4105D1F ATP-binding protein U737_02445 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) U737_02450 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control U737_02455 ENOG4105K46 50S ribosomal protein l27 U737_02460 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) U737_02465 ENOG4105EAH synthase U737_02475 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) U737_02480 ENOG4107QHF type ii secretion system protein e U737_02495 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) U737_02500 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) U737_02505 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) U737_02510 ENOG4105M6F mutator MutT protein U737_02515 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) U737_02550 ENOG4105C8Q Methyl-accepting chemotaxis U737_02555 ENOG4105BZU Histidine kinase U737_02565 ENOG4105WH1 Two component transcriptional regulator luxr family U737_02570 ENOG4105BZU Histidine kinase U737_02575 ENOG4105CZX twitching motility protein U737_02580 ENOG4105EGD dinuclear metal center protein, YbgI family U737_02585 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) U737_02600 ENOG4105EIX cytochrome c1 U737_02605 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) U737_02610 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) U737_02615 ENOG4105CIH Imidazole acetol-phosphate transaminase U737_02640 ENOG4108TGK Low-potential electron donor to a number of redox enzymes (By similarity) U737_02655 ENOG4105BZU Histidine kinase U737_02660 ENOG4105CHC glucokinase (EC 2.7.1.2) U737_02670 ENOG4105DHP deoxycytidine triphosphate deaminase U737_02705 ENOG4105CA0 peroxidase U737_02710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family U737_02715 ENOG4105BZU Histidine kinase U737_02720 ENOG4105BZU Histidine kinase U737_02725 ENOG4105C4M (Ubiquinol oxidase) subunit I U737_02730 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii U737_02740 ENOG4107TH8 cina domain protein U737_02745 ENOG4108K0D peptidase, M48 U737_02755 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) U737_02780 ENOG4105KUZ arsenate reductase U737_02785 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) U737_02790 ENOG4105BZU Histidine kinase U737_02800 ENOG4105W5Q DNA repair protein (RadC U737_02830 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) U737_02895 ENOG4105XJC Two component transcriptional regulator (Winged helix family U737_02900 ENOG4105DHQ Histidine kinase U737_02960 ENOG4108RRZ Transcription elongation factor GreB U737_02990 ENOG4107QTH restriction modification system DNA specificity domain U737_03005 ENOG4108C33 Resolvase U737_03030 ENOG4105EKQ RNA-directed DNA polymerase U737_03080 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) U737_03090 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) U737_03105 ENOG4108RAV Conserved protein U737_03130 ENOG4105C7H Helicase, RecD TraA family U737_03135 ENOG4105DK2 UPF0207 protein U737_03215 ENOG4105C3F Signal peptidase i U737_03280 ENOG4105NI8 Cytosine-specific methyltransferase U737_03295 ENOG4108UUM single-stranded DNA-binding protein U737_03370 ENOG4105W5Q DNA repair protein (RadC U737_03395 ENOG4108HHA Transketolase U737_03400 ENOG4108IUS Transketolase U737_03420 ENOG4105C1B dTDP-glucose 4-6-dehydratase U737_03435 ENOG4105EY8 ABC transporter U737_03465 ENOG4105EXC Acyl-transferase U737_03475 ENOG4105CKK Glycosyl transferase, family 2 U737_03495 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein U737_03520 ENOG4105D5U fad dependent oxidoreductase U737_03525 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) U737_03570 ENOG4105D06 uba thif-type nad fad binding protein U737_03580 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) U737_03585 ENOG4105BZU Histidine kinase U737_03590 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase U737_03595 ENOG4105EMN RNA polymerase sigma factor U737_03620 ENOG4105E0C molybdate abc transporter U737_03625 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) U737_03630 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) U737_03645 ENOG4105BZU Histidine kinase U737_03650 ENOG4105BZU Histidine kinase U737_03675 ENOG4108VPT UPF0234 protein U737_03690 ENOG4105D7A ATP-binding protein U737_03705 ENOG4106ECQ phosphomannomutase U737_03715 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) U737_03735 ENOG4105C11 sulfate adenylyltransferase), subunit 2 U737_03775 ENOG4108UK5 Transposase U737_03795 ENOG4107R3N Filamentation induced by cAMP protein fic U737_03800 ENOG4105DZR Type I site-specific deoxyribonuclease U737_03810 ENOG4108N3W hemolysin secretion protein U737_03820 ENOG4105C9U ATP-dependent DNA helicase RecQ U737_03825 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) U737_03835 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) U737_03840 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) U737_03845 ENOG4105DFF Rod shape-determining protein mreb U737_03850 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) U737_03855 ENOG4105VQ7 Rod shape-determining protein MreD U737_03860 ENOG4105CJN penicillin-binding protein U737_03865 ENOG4105CNI cell division protein FtsW U737_03870 ENOG4105CVE Lytic murein transglycosylase U737_03875 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein U737_03885 ENOG4105HZM Fha domain containing protein U737_03900 ENOG4105XJC Two component transcriptional regulator (Winged helix family U737_03905 ENOG4105DHQ Histidine kinase U737_03930 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) U737_03935 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor U737_03940 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) U737_03950 ENOG4105BZU Histidine kinase U737_03955 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) U737_03975 ENOG4105CJ1 ABC, transporter U737_03980 ENOG4107QWP ABC-2 type transporter U737_03985 ENOG4107QWP ABC-2 type transporter U737_03990 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB U737_03995 ENOG4105P1D 4fe-4s ferredoxin, iron-sulfur binding U737_04000 ENOG4105ND9 Nitrogenase-associated protein U737_04005 ENOG4105CNW domain protein U737_04010 ENOG4105KXW Ferredoxin U737_04015 ENOG4105U82 Ferredoxin U737_04020 ENOG4105PS4 nifq family U737_04045 ENOG4105XMH SpoVT AbrB domain protein U737_04065 ENOG4107YDW inorganic pyrophosphatase EC 3.6.1.1 U737_04075 ENOG4105BZU Histidine kinase U737_04085 ENOG4105NPQ Pfam:DUF403 U737_04110 ENOG4105C4K Nad synthetase U737_04115 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha U737_04120 ENOG4105CMV Succinyl-CoA synthetase subunit beta U737_04125 ENOG4107TUY Histidine kinase U737_04130 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_04140 ENOG4105BZU Histidine kinase U737_04165 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) U737_04170 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) U737_04175 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) U737_04180 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein U737_04185 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) U737_04190 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) U737_04200 ENOG4105C5T Phosphoribosyl pyrophosphate synthase U737_04205 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) U737_04210 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) U737_04230 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) U737_04240 ENOG4105PM1 preprotein translocase subunit SecE U737_04245 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) U737_04250 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) U737_04255 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) U737_04260 ENOG4108VZM 50s ribosomal protein L10 U737_04265 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) U737_04270 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) U737_04275 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) U737_04280 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) U737_04285 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) U737_04290 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) U737_04295 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) U737_04300 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) U737_04305 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) U737_04310 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) U737_04315 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) U737_04320 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity U737_04325 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) U737_04330 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) U737_04335 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) U737_04340 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) U737_04345 ENOG41083MP 50s ribosomal protein l29 U737_04350 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal U737_04355 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) U737_04360 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) U737_04375 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) U737_04380 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) U737_04385 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) U737_04390 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) U737_04395 ENOG4105VPB 50S ribosomal protein L30 U737_04400 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) U737_04405 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) U737_04410 ENOG41067V7 50S ribosomal protein L36 U737_04415 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits U737_04420 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) U737_04425 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) U737_04435 ENOG4108ZT0 50S ribosomal protein l17 U737_04445 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase U737_04455 ENOG4108DG9 Smr protein MutS2 U737_04460 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) U737_04465 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) U737_04485 ENOG4105CMR udp-glucose 4-epimerase U737_04490 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) U737_04495 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) U737_04500 ENOG4107RUY (E1 component), alpha subunit U737_04505 ENOG4105CPP Dehydrogenase, E1 component U737_04525 ENOG4105EPH radical SAM domain protein U737_04565 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase U737_04570 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase U737_04575 ENOG4105D2T synthase U737_04585 ENOG4108S0S Nucleotidyl transferase U737_04590 ENOG4105I03 Flagellin U737_04595 ENOG41063QE flagellar protein FlaG U737_04605 ENOG4105MQ3 flagellar protein FliS U737_04615 ENOG4105I03 Flagellin U737_04625 ENOG4106KVJ cytochrome C assembly protein U737_04630 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY U737_04635 ENOG4105K5M 30s ribosomal protein S16 U737_04640 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) U737_04645 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) U737_04650 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) U737_04660 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) U737_04665 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) U737_04675 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) U737_04680 ENOG4105BZU Histidine kinase U737_04690 ENOG4105DFM M18 family aminopeptidase U737_04695 ENOG4105E0X reductase U737_04700 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase U737_04715 ENOG4105CB5 ATP-dependent DNA helicase recG U737_04720 ENOG4105D0B Nitrogenase protein alpha chain U737_04725 ENOG4105DK8 Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN U737_04730 ENOG4108UR2 Nitrogen fixation protein NifX U737_04740 ENOG4108VQE nitrogen fixation protein U737_04750 ENOG4105WCA Ferredoxin U737_04765 ENOG4105PUF Ferredoxin, 2FE-2S U737_04790 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) U737_04795 ENOG4105CFU surface antigen U737_04805 ENOG4105D3Q Sugar transferase U737_04810 ENOG4105DAY polysaccharide export protein U737_04850 ENOG4108KBE Glycosyl transferase, family 2 U737_04895 ENOG4105D9P serine threonine protein kinase U737_04945 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) U737_04950 ENOG4108K8Z nad( )--dinitrogen-reductase ADP-d-ribosyltransferase U737_04955 ENOG41065RQ ADP-ribosylation crystallin J1 U737_04965 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) U737_04970 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) U737_04975 ENOG4105YAZ 4-amino-4-deoxychorismate lyase U737_04980 ENOG4105HHA aminodeoxychorismate lyase U737_04985 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) U737_04990 ENOG4107QRG dna polymerase iii U737_05000 ENOG4105F8V Hydrolase, tatD family U737_05005 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) U737_05010 ENOG4105CKK Glycosyl transferase, family 2 U737_05015 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) U737_05025 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) U737_05045 ENOG41083B7 nucleosidase (EC 3.2.2.9) U737_05060 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) U737_05070 ENOG410903C (LipO)protein U737_05075 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) U737_05080 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) U737_05085 ENOG4105CTB Polyprenyl synthetase U737_05090 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) U737_05100 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) U737_05160 ENOG4105D9M gamma-glutamylcysteine synthetase U737_05165 ENOG4105C9U ATP-dependent DNA helicase RecQ U737_05185 ENOG4105C31 Tryptophanyl-tRNA synthetase U737_05190 ENOG41080C8 DUF218 domain U737_05195 ENOG4105BZ1 (ABC) transporter U737_05210 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen U737_05225 ENOG4105C1P efflux transporter, rnd family, mfp subunit U737_05230 ENOG4105XJC Two component transcriptional regulator (Winged helix family U737_05235 ENOG4105DHQ Histidine kinase U737_05240 ENOG41077A9 carbonic anhydrase U737_05260 ENOG4105E66 phosphoriboisomerase A U737_05265 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) U737_05285 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) U737_05335 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) U737_05350 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) U737_05355 ENOG4105WBS CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) U737_05360 ENOG4105BZU Histidine kinase U737_05375 ENOG41087AY ADP-Ribose pyrophosphatase U737_05380 ENOG4105DKB L-sorbosone dehydrogenase U737_05385 ENOG4105D0M Protease HtpX homolog U737_05400 ENOG4105E0K tonB-dependent siderophore receptor U737_05440 ENOG4108UK5 Transposase U737_05445 ENOG4108UK5 Transposase U737_05450 ENOG4105E0K tonB-dependent siderophore receptor U737_05470 ENOG4108SF5 RNA Polymerase U737_05475 ENOG4105CSH Transporter U737_05480 ENOG4105DN9 Na H antiporter U737_05490 ENOG4105C3Q Glycosyl transferase, family 2 U737_05495 ENOG4105CMQ Chloride channel U737_05505 ENOG4107QWR cellulase (EC 3.2.1.4) U737_05515 ENOG4106N16 had-superfamily hydrolase, subfamily iib U737_05520 ENOG4105Q84 sucrose synthase U737_05535 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase U737_05540 ENOG4105BZU Histidine kinase U737_05550 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase U737_05555 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) U737_05560 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) U737_05565 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) U737_05605 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) U737_05610 ENOG4105F4R Transcriptional regulator mode U737_05615 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein U737_05625 ENOG4105F4R Transcriptional regulator mode U737_05640 ENOG4105FZE dinitrogenase iron-molybdenum cofactor biosynthesis U737_05655 ENOG4105D1H recombination factor protein RarA U737_05660 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) U737_05665 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) U737_05680 ENOG4105BZU Histidine kinase U737_05685 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) U737_05690 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase U737_05695 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) U737_05700 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) U737_05705 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) U737_05710 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) U737_05720 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) U737_05725 ENOG4108JJA ABC, transporter U737_05730 ENOG4105C42 Type I secretion membrane fusion protein (HlyD U737_05740 ENOG4105DFG type I secretion outer membrane protein U737_05750 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) U737_05755 ENOG4108IEG Formate dehydrogenase Alpha subunit U737_05760 ENOG4107QIZ NADH dehydrogenase U737_05775 ENOG4107TF3 peptidylprolyl cis-trans isomerase U737_05785 ENOG4105K9H YciI-like protein U737_05790 ENOG4107835 probably involved in intracellular septation (By similarity) U737_05805 ENOG4107UWY Methyltransferase U737_05825 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) U737_05835 ENOG4105KEG ribosomal-protein-alanine acetyltransferase U737_05840 ENOG4108UN4 phage SPO1 DNA polymerase-related protein U737_05845 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) U737_05850 ENOG4107S6X Glycosyl transferase, family 2 U737_05870 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase U737_05885 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase U737_05890 ENOG4108ZP8 Acetolactate synthase small subunit U737_05895 ENOG4105C7K acetolactate synthase U737_05900 ENOG4105E7D Protein of unknown function (DUF3375) U737_05940 ENOG4105WH1 Two component transcriptional regulator luxr family U737_05945 ENOG4105BZU Histidine kinase U737_05955 ENOG4108UJD 30S ribosomal protein S9 U737_05960 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) U737_05965 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_05970 ENOG4105ES5 Histidine kinase U737_05980 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B U737_05985 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) U737_05990 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) U737_05995 ENOG4108WZM domain protein U737_06000 ENOG4105C79 DNA protecting protein DprA U737_06005 ENOG4108RPN Protein smg homolog U737_06025 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation U737_06030 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) U737_06035 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) U737_06040 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) U737_06045 ENOG4105K70 DNA-binding protein U737_06060 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) U737_06065 ENOG4105RKW reductase (By U737_06075 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component U737_06080 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component U737_06105 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_06110 ENOG4105BZU Histidine kinase U737_06145 ENOG4108JUA Transcriptional regulator U737_06155 ENOG4105E18 UPF0276 protein U737_06175 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) U737_06180 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) U737_06205 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic U737_06215 ENOG4105CHH sulfate transporter U737_06220 ENOG4105EVH UPF0753 protein U737_06225 ENOG4105D65 subunit l U737_06230 ENOG4105D9P serine threonine protein kinase U737_06240 ENOG4107R3J Transporter U737_06245 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA U737_06255 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) U737_06280 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region U737_06380 ENOG4108UUM single-stranded DNA-binding protein U737_06395 ENOG4108ZXE U737_06415 ENOG4105DFS Conserved Protein U737_06425 ENOG4108F3G Type I restriction-modification system, R subunit U737_06430 ENOG4105K70 DNA-binding protein U737_06450 ENOG4105C3F Signal peptidase i U737_06525 ENOG4108IJF Heavy metal efflux pump, CzcA U737_06530 ENOG4105EP1 Efflux transporter rnd family, mfp subunit U737_06585 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase U737_06610 ENOG4108IJF Heavy metal efflux pump, CzcA U737_06745 ENOG4105DFP Integrase U737_06795 ENOG4105CJ3 phosphate transporter U737_06800 ENOG4107GRR phosphate transport regulator U737_06805 ENOG4107EFR Flavocytochrome c U737_06810 ENOG4105CPD ethanolamine ammonia-lyase U737_06815 ENOG4107FQ9 ethanolamine ammonia-lyase U737_06860 ENOG4105D6J arsenicaL-resistance protein U737_06880 ENOG4108UXE Protein tyrosine phosphatase U737_06895 ENOG4105G6Z alkaline phosphatase U737_06905 ENOG4107T31 5'-nucleotidase U737_06925 ENOG4105WQ5 TonB family U737_06945 ENOG4105E0K tonB-dependent siderophore receptor U737_06980 ENOG4105C8T Leucyl-tRNA synthetase U737_06985 ENOG4108U2H Rare lipoprotein B U737_06990 ENOG4105DJF DNA polymerase III, delta' subunit U737_07000 ENOG4105C6T cysteine synthase U737_07020 ENOG4105CVP deoxyribo-dipyrimidine photolyase U737_07030 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) U737_07040 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) U737_07045 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) U737_07075 ENOG4105CQM Urea amidohydrolase subunit alpha U737_07080 ENOG4105KI2 Urea amidohydrolase subunit beta U737_07085 ENOG4108YZ9 Urea amidohydrolase subunit gamma U737_07100 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) U737_07110 ENOG4108IV0 ABC, transporter U737_07115 ENOG4105C0Z ABC transporter U737_07135 ENOG4105C32 Amino acid ABC transporter (Permease) U737_07175 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase U737_07180 ENOG4105CHR reductase U737_07185 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase U737_07190 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) U737_07195 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) U737_07200 ENOG4105VGS 50s ribosomal protein l32 U737_07210 ENOG4108UHJ MAF-like protein U737_07220 ENOG4105E4C Lytic transglycosylase catalytic U737_07225 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR U737_07230 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) U737_07235 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) U737_07240 ENOG4105EUJ GTP cyclohydrolase i U737_07245 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) U737_07265 ENOG4105BZU Histidine kinase U737_07270 ENOG4108JUA Transcriptional regulator U737_07275 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) U737_07280 ENOG4105BZ4 penicillin-binding protein U737_07300 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) U737_07315 ENOG4107QN2 dihydrolipoyl dehydrogenase U737_07340 ENOG4107R1I NAD-dependent malic enzyme U737_07345 ENOG4105DUX Transporter U737_07365 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) U737_07370 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase U737_07375 ENOG4105CA9 Pyruvate kinase U737_07380 ENOG4105C4R Atp-dependent dna helicase U737_07390 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 U737_07395 ENOG4105VF7 tolerance protein U737_07400 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) U737_07405 ENOG4107QX9 Thiol disulfide interChange protein U737_07410 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) U737_07415 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein U737_07420 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase U737_07425 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) U737_07435 ENOG4105DR4 Methyltransferase U737_07460 ENOG4105C30 Nad-dependent epimerase dehydratase U737_07495 ENOG4105M2J Glutaredoxin U737_07510 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) U737_07520 ENOG4107QTF adenylosuccinate lyase U737_07535 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) U737_07545 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) U737_07550 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit U737_07555 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) U737_07560 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) U737_07575 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) U737_07580 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) U737_07605 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) U737_07640 ENOG4105CFH Aspartokinase U737_07670 ENOG4105C59 p-type ATPase U737_07710 ENOG4108P8R U737_07725 ENOG4105DFP Integrase U737_07740 ENOG4105CXB phosphoribosylaminoimidazole synthetase U737_07760 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_07765 ENOG4105CUX Signal transduction histidine kinase U737_07795 ENOG4105C26 Dehydrogenase U737_07830 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) U737_07835 ENOG4105K8N protein family UPF0079, ATPase U737_07840 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase U737_07845 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) U737_07850 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) U737_07855 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase U737_07860 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) U737_07870 ENOG4107QVI Methyltransferase, type 11 U737_07880 ENOG4105CUZ uba thif-type nad fad binding protein U737_07885 ENOG4105F8V Hydrolase, tatD family U737_07890 ENOG4105C5H ABC transporter U737_07895 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) U737_07900 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) U737_07905 ENOG4107QJR hflk protein U737_07910 ENOG4105EPW hflc protein U737_07915 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) U737_07920 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis U737_07925 ENOG4105KHC sulfurtransferase U737_07930 ENOG4108JA1 polyketide synthase U737_07935 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase U737_07950 ENOG4105BZU Histidine kinase U737_07955 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_07965 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) U737_07970 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) U737_07980 ENOG4108JIR Flagellum-specific ATP synthase U737_07995 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) U737_08000 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) U737_08010 ENOG4105K9Q Binds to the 23S rRNA (By similarity) U737_08015 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) U737_08025 ENOG4105BZU Histidine kinase U737_08040 ENOG4105E0K tonB-dependent siderophore receptor U737_08065 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase U737_08070 ENOG4105CDH Citrulline--aspartate ligase U737_08085 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) U737_08090 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) U737_08095 ENOG4108RXW HAD-superfamily subfamily IB hydrolase U737_08100 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) U737_08105 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) U737_08110 ENOG4105FGF GDP-mannose mannosyl hydrolase U737_08115 ENOG4107QZM n-acetylglutamate synthase U737_08130 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) U737_08135 ENOG4105C01 Dihydroxy-acid dehydratase U737_08145 ENOG4105DBV ornithine carbamoyltransferase U737_08150 ENOG4105C8Y Acetylornithine aminotransferase U737_08165 ENOG4105CMT Dihydroxyacetone kinase U737_08170 ENOG4105D4U had-superfamily hydrolase, subfamily iia U737_08185 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) U737_08190 ENOG4105CHV Transcription elongation factor NusA U737_08195 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) U737_08205 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) U737_08210 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) U737_08215 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) U737_08220 ENOG4107RA9 decarboxylase U737_08230 ENOG4105CDV Ompa motb domain protein U737_08235 ENOG4105E50 uracil-dna glycosylase U737_08240 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) U737_08245 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase U737_08255 ENOG4107QQG Dehydrogenase U737_08280 ENOG4107BJW polysaccharide deacetylase U737_08285 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family U737_08300 ENOG4105C3K feS assembly ATPase SufC U737_08315 ENOG4105C9B Cysteine desulfurase U737_08320 ENOG4108UNV SUF system FeS assembly protein, NifU family U737_08325 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) U737_08335 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) U737_08340 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) U737_08355 ENOG4105CRK lysyL-tRNA synthetase U737_08375 ENOG4105K6H D-cysteine desulfhydrase U737_08385 ENOG4105WKW Pfam:DUF1458 U737_08390 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) U737_08400 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) U737_08405 ENOG4105MYN Zinc uptake regulation protein U737_08415 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) U737_08420 ENOG4105CBX hi0933 family U737_08430 ENOG4105BZN citrate synthase U737_08440 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) U737_08465 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) U737_08470 ENOG4105X0D Fimbrial protein U737_08495 ENOG4105X0D Fimbrial protein U737_08500 ENOG4108VYJ response regulator receiver protein U737_08505 ENOG4105CBS Chea signal transduction histidine kinase U737_08510 ENOG4108V3W Chemotaxis protein, CheW U737_08515 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor U737_08515 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor U737_08520 ENOG4108V3W Chemotaxis protein, CheW U737_08525 ENOG4107QJE Chromosome Partitioning Protein U737_08535 ENOG4105BZU Histidine kinase U737_08540 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) U737_08545 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) U737_08550 ENOG4105C8Q Methyl-accepting chemotaxis U737_08565 ENOG4108IAB Phoh family U737_08580 ENOG4105DVT helicase U737_08585 ENOG41072GX Peptidase M22 Glycoprotease U737_08590 ENOG4107RTD sua5 ycio yrdc ywlc family protein U737_08595 ENOG4108Z4T Peptidase M50 U737_08605 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) U737_08610 ENOG4105FE9 pseudouridine synthase U737_08620 ENOG4108UK5 Transposase U737_08625 ENOG4105C0B DNA polymerase III (alpha subunit) U737_08640 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) U737_08645 ENOG4108VYJ response regulator receiver protein U737_08655 ENOG4105I9Z UPF0264 protein U737_08660 ENOG4105BZU Histidine kinase U737_08670 ENOG4108DQR cina-like protein U737_08675 ENOG4105C5H ABC transporter U737_08690 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_08695 ENOG4105CSR polyphosphate kinase 2 U737_08715 ENOG4108UK5 Transposase U737_08755 ENOG4107QHF type ii secretion system protein e U737_08760 ENOG4105D7Q type ii secretion system U737_08765 ENOG4108VAU general secretion pathway protein G U737_08770 ENOG4105VWV general secretion pathway protein h U737_08775 ENOG4105X5Z General secretion pathway protein I U737_08780 ENOG4108WWZ General secretion pathway protein J U737_08785 ENOG4108RTD type II secretion system protein K U737_08810 ENOG4105D5K Hemolysin activator protein U737_08820 ENOG4105E02 MotA TolQ exbB proton channel U737_08825 ENOG4105SG9 biopolymer transport protein, ExbD U737_08865 ENOG4105DAY polysaccharide export protein U737_08880 ENOG41080HI glycine oxidase U737_08890 ENOG4105NBK UPF0345 protein U737_08900 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) U737_08905 ENOG41090R7 Ferric uptake U737_08915 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) U737_08930 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) U737_08940 ENOG4108N1H methylenetetrahydrofolate dehydrogenase (NADP( U737_08945 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) U737_08955 ENOG4107QRS glycosyltransferase group 2 family protein U737_08965 ENOG4105K64 Glycosyl transferase, family 2 U737_08970 ENOG4107SJB teichoic acid biosynthesis U737_08975 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein U737_08980 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) U737_09000 ENOG4107T8Q Glycosyl transferase (Group 1 U737_09005 ENOG4105K64 Glycosyl transferase, family 2 U737_09020 ENOG4105D5G Transposase U737_09035 ENOG4107QUT magnesium and cobalt transport protein CorA U737_09040 ENOG4108JU6 CBS domain protein U737_09045 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_09050 ENOG4105CH2 amidohydrolase U737_09065 ENOG4105GVR general secretion pathway protein D U737_09080 ENOG41090VX general secretion pathway protein L U737_09085 ENOG4105UV2 general secretion pathway protein K U737_09105 ENOG4108VAU general secretion pathway protein G U737_09110 ENOG4105D7Q type ii secretion system U737_09120 ENOG4107QHF type ii secretion system protein e U737_09125 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_09130 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein U737_09140 ENOG4105BZU Histidine kinase U737_09150 ENOG4105BZU Histidine kinase U737_09165 ENOG4105QNF Outer membrane lipoprotein U737_09170 ENOG4105CVP deoxyribo-dipyrimidine photolyase U737_09180 ENOG4105ECP epimerase U737_09185 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) U737_09190 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) U737_09200 ENOG4105BZU Histidine kinase U737_09215 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) U737_09220 ENOG4105EPW hflc protein U737_09225 ENOG4107QJR hflk protein U737_09230 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) U737_09260 ENOG4105VYA Uncharacterized conserved protein (DUF2132) U737_09275 ENOG4105E3B Multicopper oxidase U737_09285 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs U737_09300 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family U737_09305 ENOG4105H3G oxidoreductase U737_09355 ENOG4105E0K tonB-dependent siderophore receptor U737_09360 ENOG4105FCD Major Facilitator U737_09375 ENOG4108W2P Methyl-accepting chemotaxis U737_09395 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) U737_09410 ENOG4108YZY peptidylprolyl cis-trans isomerase U737_09435 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) U737_09440 ENOG41063Z6 transcriptional regulator, lysR family U737_09455 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) U737_09460 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) U737_09465 ENOG4105BZU Histidine kinase U737_09470 ENOG4107SDU Methyl-accepting chemotaxis U737_09475 ENOG4108VYJ response regulator receiver protein U737_09485 ENOG4105CBS Chea signal transduction histidine kinase U737_09490 ENOG4105C8Q Methyl-accepting chemotaxis U737_09495 ENOG4108V3W Chemotaxis protein, CheW U737_09500 ENOG410828M hemerythrin-like, metal-binding protein U737_09505 ENOG4105C8Q Methyl-accepting chemotaxis U737_09510 ENOG4105CKU formyltetrahydrofolate synthetase U737_09515 ENOG4105E66 phosphoriboisomerase A U737_09520 ENOG4105C7B Threonine dehydratase U737_09525 ENOG4105E4G Type IV pilus U737_09575 ENOG4107QHF type ii secretion system protein e U737_09580 ENOG4105D7Q type ii secretion system U737_09590 ENOG4105WH1 Two component transcriptional regulator luxr family U737_09600 ENOG4105CX6 glutaminyL-tRNA synthetase U737_09605 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) U737_09700 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) U737_09740 ENOG4108VKQ nitriC oxide reductase U737_09750 ENOG4105KPV Transcriptional regulator U737_09755 ENOG4105C5X domain protein U737_09760 ENOG4105C7S Dehydrogenase U737_09765 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 U737_09795 ENOG4108IYU L-aspartate oxidase U737_09800 ENOG4105EMN RNA polymerase sigma factor U737_09815 ENOG4105C0H protease U737_09850 ENOG4105BZU Histidine kinase U737_09870 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) U737_09875 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) U737_09890 ENOG4107YBY Hydrolase U737_09915 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) U737_09920 ENOG4108UGV hypoxanthine phosphoribosyltransferase U737_09925 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) U737_09945 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB U737_09960 ENOG4107QMS site-determining protein U737_09970 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) U737_09975 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) U737_09980 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) U737_09990 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) U737_09995 ENOG4105W3S hemerythrin-like, metal-binding protein U737_10005 ENOG4105BZ9 Cytochrome C oxidase, subunit I U737_10010 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) U737_10015 ENOG4107QS1 Cytochrome C Oxidase, Subunit III U737_10035 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) U737_10040 ENOG4105CAK Cell division ATP-binding protein ftsE U737_10045 ENOG4105CRP Part of the ABC transporter FtsEX involved in U737_10050 ENOG4108ZZ3 UPF0260 protein U737_10075 ENOG4108Z0R Transferase U737_10090 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 U737_10100 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) U737_10105 ENOG4105CB5 ATP-dependent DNA helicase recG U737_10110 ENOG4105KME endoribonuclease L-psp U737_10115 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) U737_10120 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) U737_10125 ENOG4105ERG peptidase m48, ste24p U737_10130 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) U737_10135 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) U737_10145 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase U737_10150 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) U737_10255 ENOG4105C5R Aminotransferase U737_10265 ENOG4105CMV Succinyl-CoA synthetase subunit beta U737_10270 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha U737_10275 ENOG4105C0D helicase U737_10290 ENOG4107RWR Sodium hydrogen exchanger U737_10325 ENOG4105CHH sulfate transporter U737_10330 ENOG4107BJW polysaccharide deacetylase U737_10335 ENOG4105CND Glycosyl transferase, family 2 U737_10350 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen U737_10360 ENOG4107QSA Oxaloacetate decarboxylase U737_10365 ENOG4105D9Q decarboxylase (Beta subunit) U737_10420 ENOG41090R9 glycosyltransferase U737_10425 ENOG4105CCT upf0313 protein U737_10430 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) U737_10475 ENOG4105CFG Acts as a chaperone (By similarity) U737_10480 ENOG4105CDV Ompa motb domain protein U737_10490 ENOG4105E0K tonB-dependent siderophore receptor U737_10510 ENOG4105VUH addiction module killer protein U737_10515 ENOG4105YES addiction module antidote protein U737_10545 ENOG4105E0K tonB-dependent siderophore receptor U737_10560 ENOG4105BZU Histidine kinase U737_10565 ENOG4105CMR udp-glucose 4-epimerase U737_10570 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) U737_10580 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) U737_10585 ENOG4107SC1 transglycosylase U737_10590 ENOG4105BZ1 (ABC) transporter U737_10595 ENOG4105DB7 PHP domain protein U737_10600 ENOG4105BZU Histidine kinase U737_10605 ENOG4105BZU Histidine kinase U737_10610 ENOG4105BZU Histidine kinase U737_10620 ENOG4105D05 Receptor U737_10640 ENOG4105EW9 transcriptional regulator AsnC family U737_10650 ENOG4105FDR Membrane U737_10675 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) U737_10680 ENOG4108JU7 Transcriptional regulator U737_10735 ENOG4106RE7 Cytochrome U737_10750 ENOG4105C9B Cysteine desulfurase U737_10755 ENOG4105ESN nucleotide-binding protein U737_10760 ENOG4105D7W serine acetyltransferase U737_10765 ENOG4105C6T cysteine synthase U737_10770 ENOG4107R11 Transcriptional regulator U737_10775 ENOG4108IJ6 ABC transporter U737_10780 ENOG4105ECW sulfate abc transporter U737_10785 ENOG4108I5D sulfate abc transporter U737_10800 ENOG4105BZU Histidine kinase U737_10805 ENOG4105BZU Histidine kinase U737_10815 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component U737_10835 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase U737_10860 ENOG4105ENJ RND efflux system, outer membrane lipoprotein U737_10865 ENOG4105BZS acriflavin resistance protein U737_10870 ENOG4105BZS acriflavin resistance protein U737_10900 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) U737_10905 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) U737_10920 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) U737_10930 ENOG4108UK5 Transposase U737_11020 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) U737_11025 ENOG4108P4C Formaldehyde-activating enzyme U737_11040 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding U737_11045 ENOG4105XRQ Xanthine dehydrogenase accessory factor U737_11050 ENOG4105CEY Amp-dependent synthetase and ligase U737_11055 ENOG4105WQI isochorismatase U737_11060 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase U737_11065 ENOG4105E4F Isochorismate synthase U737_11080 ENOG4105Q26 Siderophore-interacting protein U737_11085 ENOG4108MES Periplasmic binding protein U737_11090 ENOG4105DQ5 transport system permease protein U737_11095 ENOG4105TVJ transport system, permease U737_11110 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase U737_11115 ENOG4105XRQ Xanthine dehydrogenase accessory factor U737_11120 ENOG4105CA0 peroxidase U737_11140 ENOG4105XRQ Xanthine dehydrogenase accessory factor U737_11145 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) U737_11155 ENOG4105CHH sulfate transporter U737_11165 ENOG4105FQ6 thiopurine methyltransferase U737_11175 ENOG4105C4M (Ubiquinol oxidase) subunit I U737_11180 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii U737_11195 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase U737_11210 ENOG4105BZS acriflavin resistance protein U737_11245 ENOG4105BZU Histidine kinase U737_11250 ENOG4105DSY exodeoxyribonuclease V, gamma U737_11255 ENOG4107QKA exodeoxyribonuclease V beta U737_11260 ENOG4107QYX exodeoxyribonuclease v alpha U737_11280 ENOG4105DFG type I secretion outer membrane protein U737_11300 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) U737_11305 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) U737_11310 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters U737_11315 ENOG4105CHM Aminotransferase U737_11320 ENOG41085GJ domain protein U737_11330 ENOG4105CVM Molybdenum cofactor synthesis domain protein U737_11335 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b U737_11340 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) U737_11345 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) U737_11355 ENOG4105C9X ppx gppa phosphatase U737_11360 ENOG4105DA5 (ABC) transporter U737_11365 ENOG4105E3A (ABC) transporter U737_11375 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 U737_11395 ENOG4107R3J Transporter U737_11400 ENOG4107QZF nitrite reductase NADPH large subunit U737_11405 ENOG4105WZK nitrite reductase NADPH small subunit U737_11410 ENOG4105JAB phenazine biosynthesis protein, phzf family U737_11420 ENOG4105CT7 inner membrane cred family protein U737_11440 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) U737_11445 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase U737_11465 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) U737_11470 ENOG4105W49 UPF0434 protein U737_11475 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) U737_11505 ENOG4105BZU Histidine kinase U737_11510 ENOG4108JDX DNA polymerase iii, epsilon subunit U737_11520 ENOG4105C6T cysteine synthase U737_11525 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) U737_11535 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) U737_11540 ENOG4105CEY Amp-dependent synthetase and ligase U737_11545 ENOG4107T3I fad-binding protein U737_11550 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) U737_11560 ENOG4105C2D reductase U737_11565 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) U737_11620 ENOG4105C1G acyl-Coa dehydrogenase U737_11690 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) U737_11715 ENOG4105C7R Atpase associated with various cellular activities aaa_3 U737_11730 ENOG4108303 d-xylulose 5-phosphate d-fructose 6-phosphate phosphoketolase U737_11765 ENOG4105CJB Exodeoxyribonuclease I U737_11805 ENOG41088T4 Helicase IV U737_11840 ENOG4105C1J atp-dependent rna helicase U737_11850 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) U737_11865 ENOG4107QIJ Aconitate hydratase 2 U737_11875 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) U737_11880 ENOG4108IUW ABC transporter U737_11920 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) U737_11945 ENOG4105BZU Histidine kinase U737_11950 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase U737_11960 ENOG4105D7T ABC transporter U737_11980 ENOG4108IFG nitrite reductase, (NAD(P)H) U737_11990 ENOG41066DG (EAL) domain protein U737_12025 ENOG4105C7R Atpase associated with various cellular activities aaa_3 U737_12035 ENOG4105P0N Methanol dehydrogenase beta subunit U737_12040 ENOG4108VFM cytochrome C, class I U737_12045 ENOG4108Q1J Extracellular solute-binding protein, family 3 U737_12050 ENOG41089S2 PQQ-dependent dehydrogenase, methanol ethanol family U737_12055 ENOG4105WH1 Two component transcriptional regulator luxr family U737_12100 ENOG4105ENJ RND efflux system, outer membrane lipoprotein U737_12110 ENOG4105E0K tonB-dependent siderophore receptor U737_12130 ENOG4108SF5 RNA Polymerase U737_12180 ENOG4105F4I Transcriptional regulator U737_12190 ENOG4108RR8 protoporphyrinogen oxidase U737_12285 ENOG4105VUH addiction module killer protein U737_12295 ENOG4108KU3 Integrase U737_12320 ENOG4108ZAI phosphatidylglycerophosphatase a U737_12325 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) U737_12330 ENOG4108AJD Involved in the transcription termination process (By similarity) U737_12335 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) U737_12340 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) U737_12355 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) U737_12360 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) U737_12365 ENOG4105EGS Mechanosensitive ion channel U737_12375 ENOG4105VW4 glutaredoxin 3 U737_12385 ENOG4105C28 cystathionine U737_12390 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase U737_12395 ENOG4105E96 Colicin v production protein U737_12405 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase U737_12410 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) U737_12415 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) U737_12420 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) U737_12425 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase U737_12435 ENOG4105CJ2 (LipO)protein U737_12445 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) U737_12450 ENOG4105C8J )-transporter U737_12455 ENOG4108Z1B Cyclase dehydrase U737_12460 ENOG4105VDB UPF0125 protein U737_12495 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase U737_12500 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) U737_12505 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) U737_12520 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) U737_12540 ENOG4105WQ5 TonB family U737_12550 ENOG4105SG9 biopolymer transport protein, ExbD U737_12580 ENOG4105F4I Transcriptional regulator U737_12600 ENOG41061CK Antibiotic biosynthesis monooxygenase U737_12635 ENOG4105YVM Phosphoesterase, PA-phosphatase related U737_12640 ENOG4105KD7 acetyltransferase U737_12660 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) U737_12675 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) U737_12760 ENOG4107YPT transcriptional regulator U737_12790 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein U737_12800 ENOG4105HP8 regulator of competence-specific genes U737_12875 ENOG41085W3 Transposase U737_12900 ENOG4105C5Q Transcriptional regulator U737_12935 ENOG4105CJ3 phosphate transporter U737_12970 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase U737_12975 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) U737_12990 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase U737_13005 ENOG4105E18 UPF0276 protein U737_13040 ENOG4107SWG transcriptional regulator MERR family U737_13080 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) U737_13095 ENOG4105CR8 Transcriptional regulator U737_13170 ENOG4105C3F Signal peptidase i U737_13190 ENOG4105K70 DNA-binding protein U737_13330 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) U737_13340 ENOG4105E4R Precorrin-3B C17-methyltransferase U737_13350 ENOG4108P62 biosynthesis protein (CbiG) U737_13355 ENOG4105DVK Precorrin-2 c20-methyltransferase U737_13360 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase U737_13365 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) U737_13370 ENOG41081F0 Precorrin-8x methylmutase U737_13375 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein U737_13380 ENOG4105CIA precorrin-4 C(11)-methyltransferase U737_13385 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) U737_13420 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region U737_13435 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) U737_13440 ENOG4105BZU Histidine kinase U737_13455 ENOG4105T95 Thiol disulfide interChange protein U737_13460 ENOG4105DZP Membrane-associated zinc metalloprotease U737_13465 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) U737_13470 ENOG4105KNE Phosphatidate cytidylyltransferase U737_13475 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) U737_13480 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) U737_13485 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) U737_13490 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) U737_13495 ENOG4105CE9 30S ribosomal protein S2 U737_13500 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) U737_13505 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) U737_13510 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family U737_13515 ENOG4105CBC glutamate synthase U737_13520 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) U737_13545 ENOG4108V0P LemA family U737_13560 ENOG4105KSC Transcriptional regulator, TraR DksA family U737_13565 ENOG4105BZU Histidine kinase U737_13570 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) U737_13605 ENOG4108JJA ABC, transporter U737_13610 ENOG4108MBX Secretion Protein U737_13650 ENOG4108T5G Adenylate U737_13660 ENOG4105DY2 Paraquat-inducible protein b U737_13665 ENOG4105DHJ ABC, transporter U737_13670 ENOG4105CY3 ABC transporter, permease U737_13675 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase U737_13680 ENOG4105BZU Histidine kinase U737_13685 ENOG4108UUM single-stranded DNA-binding protein U737_13690 ENOG4107RDB Major Facilitator U737_13700 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) U737_13715 ENOG4107XZC Restriction modification system DNA (Specificity U737_13735 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase U737_13750 ENOG4105C3G gtp-binding protein U737_13765 ENOG4105BZU Histidine kinase U737_13780 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) U737_13810 ENOG4108EC8 DNA internalization-related competence protein ComEC U737_13825 ENOG4105BZU Histidine kinase U737_13835 ENOG4105D05 Receptor U737_13845 ENOG4107T0K Adenylate cyclase U737_13860 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor U737_13890 ENOG4105CH7 arginosuccinase U737_13895 ENOG4105E0F Histidine kinase U737_13900 ENOG4105XJC Two component transcriptional regulator (Winged helix family U737_13920 ENOG4105CEY Amp-dependent synthetase and ligase U737_13930 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) U737_13940 ENOG4105PTV Nudix Hydrolase U737_13960 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) U737_13980 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) U737_13985 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) U737_13990 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) U737_13995 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) U737_14005 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) U737_14015 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) U737_14025 ENOG4105ED9 Protein of unknown function (DUF455) U737_14085 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) U737_14090 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) U737_14095 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) U737_14100 ENOG41082NX 50s ribosomal protein l35 U737_14105 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) U737_14110 ENOG4105C22 threonyL-tRNA synthetase U737_14130 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) U737_14135 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) U737_14150 ENOG4105EMN RNA polymerase sigma factor U737_14180 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) U737_14185 ENOG4105BZ1 (ABC) transporter U737_14195 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) U737_14215 ENOG4107T8Q Glycosyl transferase (Group 1 U737_14245 ENOG4105C6T cysteine synthase U737_14265 ENOG4105CQ7 ATP-dependent helicase U737_14290 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) U737_14305 ENOG4105E6M Sulphatase-modifying factor protein U737_14310 ENOG4105E6M Sulphatase-modifying factor protein U737_14330 ENOG4107UWY Methyltransferase U737_14350 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) U737_14375 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) U737_14380 ENOG4105D22 carbon starvation protein U737_14395 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) U737_14405 ENOG4105CJ1 ABC, transporter U737_14425 ENOG4105DCF alanine dehydrogenase U737_14430 ENOG4105D4P Coproporphyrinogen iii oxidase U737_14435 ENOG4108M1T Cytochrome c-type biogenesis protein U737_14440 ENOG4105KWW Biogenesis protein U737_14445 ENOG4107QX9 Thiol disulfide interChange protein U737_14450 ENOG4105DA4 cytochrome c-type biogenesis protein U737_14455 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) U737_14460 ENOG41067VX Heme exporter protein U737_14465 ENOG41060IM Heme exporter protein U737_14470 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) U737_14475 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) U737_14480 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) U737_14485 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit U737_14490 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) U737_14505 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) U737_14510 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) U737_14520 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase U737_14530 ENOG4105CIH Imidazole acetol-phosphate transaminase U737_14535 ENOG4105CQC Prephenate dehydratase U737_14540 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) U737_14545 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) U737_14560 ENOG4105C8Q Methyl-accepting chemotaxis U737_14565 ENOG4108HU6 Metal dependent phosphohydrolase U737_14570 ENOG4105WH1 Two component transcriptional regulator luxr family U737_14575 ENOG4105BZU Histidine kinase U737_14580 ENOG4108ETH Formylglycinamide ribotide synthetase U737_14590 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) U737_14605 ENOG4107G9V glycosyl transferase, family 39 U737_14610 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) U737_14620 ENOG4105D6E homoserine dehydrogenase U737_14625 ENOG4105CHM Aminotransferase U737_14640 ENOG4105CPF Cell wall formation (By similarity) U737_14645 ENOG4108MGF sugar kinase U737_14650 ENOG4107QPV Serine Threonine protein kinase U737_14660 ENOG4105EJC lysr family transcriptional regulator U737_14675 ENOG4105CA0 peroxidase U737_14680 ENOG4105BZU Histidine kinase U737_14695 ENOG4105BZU Histidine kinase U737_14700 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase U737_14715 ENOG4107S2Z UPF0761 membrane protein U737_14745 ENOG4105BZ1 (ABC) transporter U737_14760 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) U737_14765 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) U737_14805 ENOG4108P4C Formaldehyde-activating enzyme U737_14815 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) U737_14820 ENOG41068T5 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT (By similarity) U737_14825 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain U737_14880 ENOG4108JJA ABC, transporter U737_14915 ENOG4105C42 Type I secretion membrane fusion protein (HlyD U737_14990 ENOG4105K70 DNA-binding protein U737_15035 ENOG4105C7H Helicase, RecD TraA family U737_15050 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) U737_15105 ENOG4105C3F Signal peptidase i U737_15150 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS U737_15195 ENOG4105C9U ATP-dependent DNA helicase RecQ U737_15200 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) U737_15205 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase U737_15210 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) U737_15215 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) U737_15345 ENOG4105VZ9 UPF0235 protein U737_15390 ENOG4106TD9 Diguanylate cyclase U737_15400 ENOG4105K5B UPF0225 protein U737_15405 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) U737_15415 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving U737_15425 ENOG4105C1A potassium transporter peripheral membrane U737_15445 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) U737_15450 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase U737_15470 ENOG41079HR Phosphate-Selective Porin O and P U737_15475 ENOG41082IR Excinuclease ABC C subunit domain protein U737_15485 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) U737_15490 ENOG4105D1A Methyltransferase U737_15495 ENOG4105E9H Lytic Murein transglycosylase U737_15515 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) U737_15525 ENOG4105CDV Ompa motb domain protein U737_15535 ENOG4105C0B DNA polymerase III (alpha subunit) U737_15545 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) U737_15550 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) U737_15560 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane U737_15565 ENOG4107S7U Sulfide dehydrogenase U737_15570 ENOG4105VBD cytochrome C, class I U737_15575 ENOG4105C2N RNA methyltransferase TrmH family group 3 U737_15580 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) U737_15610 ENOG4105VEJ Heat shock protein U737_15615 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) U737_15620 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) U737_15625 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) U737_15630 ENOG4105CFP Peptidase U32 U737_15640 ENOG4105K64 Glycosyl transferase, family 2 U737_15655 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase U737_15685 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) U737_15725 ENOG4105CKK Glycosyl transferase, family 2 U737_15730 ENOG4105C7K acetolactate synthase U737_15735 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase U737_15740 ENOG4105FAW cDP-glucose 4,6-dehydratase U737_15745 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase U737_15760 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH U737_15770 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase U737_15780 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase U737_15795 ENOG4105ETX regulatoR U737_15800 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) U737_15815 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) U737_15820 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) U737_15825 ENOG4106UX7 integral membrane protein U737_15830 ENOG4108N3W hemolysin secretion protein U737_15870 ENOG4105CWB LysR family transcriptional Regulator U737_15895 ENOG4105EFZ amidohydrolase U737_15905 ENOG4105EGS Mechanosensitive ion channel U737_15915 ENOG4105CKD glutathione-regulated potassium-efflux system protein U737_15920 ENOG4105C3J Cysteine desulfurase U737_15935 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) U737_15940 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) U737_15945 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) U737_15950 ENOG4105C08 Histidine kinase U737_15955 ENOG4105EEX Two component transcriptional regulator (Winged helix family U737_15960 ENOG4105BZU Histidine kinase U737_15965 ENOG4105VG1 fes assembly suf system protein U737_15975 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) U737_15980 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) U737_15985 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) U737_15990 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_15995 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) U737_16000 ENOG4105EXN Sulfate transport protein CysZ U737_16030 ENOG4108NKV transcriptional regulator U737_16040 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A U737_16060 ENOG4105E0K tonB-dependent siderophore receptor U737_16080 ENOG4107R11 Transcriptional regulator U737_16085 ENOG4105BZU Histidine kinase U737_16120 ENOG4105M0C cytoplasmic protein U737_16170 ENOG4105VCQ rubredoxin U737_16180 ENOG4105EPW hflc protein U737_16185 ENOG4107QJR hflk protein U737_16190 ENOG4105BZU Histidine kinase U737_16195 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen U737_16215 ENOG4105I03 Flagellin U737_16235 ENOG4107QHF type ii secretion system protein e U737_16240 ENOG4105CDY transcriptional regulatory protein U737_16245 ENOG4105BZU Histidine kinase U737_16255 ENOG4105BZU Histidine kinase U737_16270 ENOG4105C5Q Transcriptional regulator U737_16280 ENOG4106EDX Hemin uptake protein U737_16315 ENOG4106QJH hemin transport protein U737_16320 ENOG4108WHG pyridoxamine 5'-phosphate U737_16325 ENOG4107R4I Periplasmic binding protein U737_16330 ENOG4105EHG Permease protein U737_16335 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) U737_16350 ENOG4108MBX Secretion Protein U737_16385 ENOG4107RAN Peptidase, M16 U737_16390 ENOG4108JJA ABC, transporter U737_16405 ENOG4108ESX Receptor U737_16415 ENOG4107E2E PKHD-type hydroxylase U737_16420 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) U737_16435 ENOG4105BZU Histidine kinase U737_16440 ENOG4105BZU Histidine kinase U737_16475 ENOG4105BZU Histidine kinase U737_16485 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein U737_16490 ENOG4105NBF ammecr1 domain protein U737_16495 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase U737_16500 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) U737_16505 ENOG4105C01 Dihydroxy-acid dehydratase U737_16510 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) U737_16515 ENOG4108UHU Aldolase U737_16520 ENOG4108VKM cytochrome b561 U737_16530 ENOG4108K0D peptidase, M48 U737_16535 ENOG4108M3P Membrane U737_16540 ENOG4105C8Q Methyl-accepting chemotaxis U737_16550 ENOG4105BZU Histidine kinase U737_16555 ENOG410812K response regulator receiver protein U737_16565 ENOG4105DJV ribulose-phosphate 3-epimerase U737_16580 ENOG4105ECY inositol monophosphatase U737_16585 ENOG4105BZU Histidine kinase U737_16590 ENOG4108YZA Nitrogen regulatory protein pii U737_16595 ENOG4105BZU Histidine kinase U737_16600 ENOG4108YZA Nitrogen regulatory protein pii U737_16610 ENOG4105C5F glutamine synthetase U737_16620 ENOG4105EJQ L-serine dehydratase U737_16630 ENOG4108MN8 Membrane U737_16635 ENOG4108Z18 K06886 hemoglobin U737_16650 ENOG4108VKG metal-dependent hydrolase U737_16655 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen U737_16670 ENOG4105C6K Malic enzyme U737_16680 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) U737_16710 ENOG4105DCC Formylmethanofuran dehydrogenase subunit A U737_16715 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) U737_16720 ENOG4105CKI cobalamin synthesis protein U737_16725 ENOG4107QRP cobalamin biosynthesis protein CobW U737_16735 ENOG4105BZU Histidine kinase U737_16750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family U737_16755 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase U737_16760 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) U737_16765 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) U737_16775 ENOG4105CK5 oxidoreductase U737_16795 ENOG4105C8Q Methyl-accepting chemotaxis U737_16805 ENOG4105C59 p-type ATPase U737_16815 ENOG4105D58 Diguanylate phosphodiesterase U737_16825 ENOG41075W9 High frequency lysogenization protein HflD homolog U737_16830 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) U737_16855 ENOG4105C02 permease U737_16860 ENOG4105DQR SNARE associated Golgi U737_16865 ENOG4105VEQ Cold shock protein U737_16880 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase U737_16910 ENOG4105W3H MtN3 and saliva related transmembrane protein U737_16920 ENOG4105CNU cell division protein FtsK U737_16925 ENOG4105C3M thioredoxin reductase U737_16935 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) U737_16945 ENOG4105BZU Histidine kinase U737_16960 ENOG4105BZU Histidine kinase U737_17015 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein U737_17020 ENOG4105C1J atp-dependent rna helicase U737_17035 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) U737_17045 ENOG4105EAQ (twin-arginine translocation) pathway signal U737_17060 ENOG4105VCQ rubredoxin U737_17065 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) U737_17070 ENOG4105WH1 Two component transcriptional regulator luxr family U737_17075 ENOG4108M6X Dehydrogenase U737_17080 ENOG4108M6X Dehydrogenase U737_17085 ENOG4105ECY inositol monophosphatase U737_17100 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family U737_17105 ENOG4105C3J Cysteine desulfurase U737_17110 ENOG4108Z4V iron-sulfur cluster assembly U737_17120 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) U737_17145 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein U737_17170 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) U737_17180 ENOG4105K56 Transcriptional regulator U737_17190 ENOG4105J12 Multidrug resistance protein mdtN U737_17225 ENOG4105K6V RNA polymerase U737_17235 ENOG4105C5H ABC transporter U737_17260 ENOG4105BZU Histidine kinase U737_17270 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) U737_17280 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) U737_17285 ENOG4105TMB Formate nitrite transporter U737_17295 ENOG4106032 Glutathionylspermidine synthase U737_17305 ENOG4105E3W Two component transcriptional regulator (Winged helix family U737_17310 ENOG4105EB3 Histidine kinase U737_17340 ENOG4105WH1 Two component transcriptional regulator luxr family U737_17355 ENOG4105CPQ Dehydrogenase U737_17360 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) U737_17385 ENOG4105BZU Histidine kinase U737_17390 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) U737_17395 ENOG4105CHB tonB-dependent Receptor U737_17405 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) U737_17410 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) U737_17415 ENOG4105EHM Aminoglycoside phosphotransferase U737_17420 ENOG4108S0S Nucleotidyl transferase U737_17440 ENOG4105CKK Glycosyl transferase, family 2 U737_17450 ENOG4105EKE dihydroorotase U737_17460 ENOG4105C9M aspartyl-trna synthetase U737_17470 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) U737_17475 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) U737_17480 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein U737_17485 ENOG4105BZU Histidine kinase U737_17500 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_17510 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) U737_17515 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) U737_17520 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) U737_17525 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) U737_17535 ENOG4105C3F Signal peptidase i U737_17540 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) U737_17545 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) U737_17550 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) U737_17555 ENOG4105DN9 Na H antiporter U737_17560 ENOG4105C08 Histidine kinase U737_17565 ENOG4105EEX Two component transcriptional regulator (Winged helix family U737_17575 ENOG4107YRI Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) U737_17580 ENOG4105D00 flagellar biosynthetic protein flhB U737_17585 ENOG4105DJ4 phosphatidylserine decarboxylase U737_17590 ENOG4105VIE preprotein translocase, subunit YajC U737_17595 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) U737_17600 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) U737_17605 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs U737_17615 ENOG4105CUT histidyl-tRNA synthetase U737_17625 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) U737_17630 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) U737_17635 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) U737_17665 ENOG4105BZU Histidine kinase U737_17675 ENOG4105BZU Histidine kinase U737_17680 ENOG4108ZXC Two component transcriptional regulator, luxr family U737_17700 ENOG4105BZU Histidine kinase U737_17705 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase U737_17730 ENOG4105C1J atp-dependent rna helicase U737_17740 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) U737_17745 ENOG4105E09 nadh pyrophosphatase U737_17750 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) U737_17755 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) U737_17775 ENOG4105CFG Acts as a chaperone (By similarity) U737_17780 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ U737_17785 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) U737_17795 ENOG4105D05 Receptor U737_17800 ENOG4105CTK cobaltochelatase, cobn subunit U737_17830 ENOG4105MRR Transcriptional regulator (By similarity) U737_17875 ENOG4105IFJ Histidine kinase U737_17880 ENOG4105XJC Two component transcriptional regulator (Winged helix family U737_17890 ENOG4105D2N Aldolase U737_17895 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_17900 ENOG4105BZU Histidine kinase U737_17905 ENOG4105CA0 peroxidase U737_17920 ENOG4107QTH restriction modification system DNA specificity domain U737_17945 ENOG4108F3G Type I restriction-modification system, R subunit U737_18030 ENOG4107EJC Preprotein translocase subunit SecG U737_18035 ENOG4105CP7 Triose-phosphate isomerase U737_18040 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) U737_18045 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) U737_18055 ENOG4105HBR Rna-binding protein U737_18060 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) U737_18065 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain U737_18070 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain U737_18080 ENOG4105E3W Two component transcriptional regulator (Winged helix family U737_18085 ENOG4105E0F Histidine kinase U737_18105 ENOG4106RE7 Cytochrome U737_18110 ENOG4105D0C transport protein U737_18140 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) U737_18145 ENOG4105BZU Histidine kinase U737_18170 ENOG4105NAA Cytochrome C oxidase, subunit II U737_18175 ENOG4107RQ2 Cytochrome c oxidase, subunit I U737_18195 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_18200 ENOG4108UQY Iron-storage protein U737_18210 ENOG4105VDB UPF0125 protein U737_18215 ENOG4108E8M Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) U737_18220 ENOG4108UQQ Electron transport complex U737_18225 ENOG4105D6A Electron transport complex U737_18230 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) U737_18235 ENOG4108R3D Electron transport complex U737_18240 ENOG4105DGN Electron transport complex U737_18245 ENOG4105DS4 PAS PAC sensor Signal transduction histidine kinase U737_18250 ENOG4108JUA Transcriptional regulator U737_18255 ENOG410908R Methenyltetrahydrofolate cyclohydrolase U737_18260 ENOG4105C8N cysteinyl-tRNA synthetase U737_18270 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) U737_18295 ENOG4107P5I polyketide synthase U737_18355 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) U737_18360 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) U737_18365 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) U737_18370 ENOG4105DC1 bifunctional purine biosynthesis protein purh U737_18375 ENOG4105C12 Phosphoribosylglycinamide synthetase U737_18395 ENOG4105BZM domain protein U737_18405 ENOG4105EYH Exonuclease U737_18420 ENOG4105CAQ asparagine synthetase U737_18425 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) U737_18430 ENOG4105JNK Glycosyl transferase (Group 1 U737_18435 ENOG4107SBE Glycosyl transferase (Group 1 U737_18455 ENOG4105CAQ asparagine synthetase U737_18460 ENOG4105CPK Glycosyl transferase (Group 1 U737_18480 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase U737_18495 ENOG4108QV3 biosynthesis protein U737_18530 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_18560 ENOG4105D7K pfkb domain protein U737_18570 ENOG4105CW7 secretion protein, HlyD family U737_18575 ENOG4105ETP RND efflux system, outer membrane lipoprotein U737_18590 ENOG4105DUM transcriptional regulator, lysR family U737_18610 ENOG4105DZ1 carboxypeptidase U737_18615 ENOG4105F0I Aminotransferase U737_18620 ENOG4108Z43 UPF0250 protein U737_18625 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) U737_18630 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) U737_18640 ENOG41061ZR Transcriptional regulator U737_18680 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving U737_18710 ENOG4105BZU Histidine kinase U737_18775 ENOG4105VTR Integrase U737_18835 ENOG4105YAJ CopG Arc MetJ U737_18875 ENOG4107QMH DNA methylase U737_18890 ENOG4105C0D helicase U737_18900 ENOG4105D5G Transposase U737_18915 ENOG4105W5Q DNA repair protein (RadC U737_18925 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) U737_18940 ENOG4108KU3 Integrase U737_18995 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) U737_19000 ENOG4105KT5 UmuD protein U737_19005 ENOG4108RAV Conserved protein U737_19090 ENOG4105VTR Integrase U737_19105 ENOG4108UYB regulatoR U737_19110 ENOG4105TX3 Histidine kinase U737_19135 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving U737_19140 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) U737_19175 ENOG4107RFW hydrolase family 57 U737_19205 ENOG4105BZA Phosphoglycerate kinase U737_19215 ENOG4108UK5 Transposase U737_19240 ENOG4108SF5 RNA Polymerase U737_19265 ENOG4105DZ1 carboxypeptidase U737_19270 ENOG41069P5 Protein slyX homolog U737_19285 ENOG4105CVG Homoserine O-transsuccinylase U737_19290 ENOG4107Y2X deaminase U737_19300 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) U737_19305 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) U737_19315 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) U737_19330 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) U737_19375 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) U737_19400 ENOG4105DJY efflux transporter, rnd family, mfp subunit U737_19405 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) U737_19420 ENOG4108UK5 Transposase U737_19425 ENOG4108UN4 phage SPO1 DNA polymerase-related protein U737_19430 ENOG4105CGK Exodeoxyribonuclease III U737_19435 ENOG4105CUB amino acid U737_19465 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) U737_19470 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b U737_19475 ENOG4105EUB pirin domain protein U737_19480 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) U737_19485 ENOG4105EXG Transcriptional regulator U737_19495 ENOG4105CHH sulfate transporter U737_19500 ENOG41077A9 carbonic anhydrase U737_19505 ENOG4108RU0 short-chain dehydrogenase reductase U737_19515 ENOG4105ECY inositol monophosphatase U737_19535 ENOG410689M (LipO)protein U737_19550 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) U737_19555 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) U737_19560 ENOG4105DZG Dehydrogenase U737_19570 ENOG4107SBB 4-alpha-glucanotransferase (EC 2.4.1.25) U737_19580 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) U737_19585 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) U737_19590 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) U737_19600 ENOG4107RUE extracellular solute-binding protein family 1 U737_19605 ENOG4105BZU Histidine kinase U737_19610 ENOG4108JU5 Magnesium and cobalt efflux protein U737_19615 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) U737_19620 ENOG4105C9A Phoh family U737_19625 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) U737_19640 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) U737_19645 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) U737_19655 ENOG4105KCK Peptidoglycan-associated lipoprotein U737_19660 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) U737_19670 ENOG4105M8F Biopolymer transport protein exbD tolR U737_19675 ENOG4105E02 MotA TolQ exbB proton channel U737_19680 ENOG4107YD3 Thioesterase U737_19685 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) U737_19690 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) U737_19695 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) U737_19700 ENOG4105CDY transcriptional regulatory protein U737_19745 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) U737_19755 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) U737_19760 ENOG4108YX9 iron--sulfur cluster insertion protein erpA U737_19770 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) U737_19775 ENOG4108UMR transcriptional regulator AsnC family U737_19795 ENOG4106P6N cytochrome d1 heme region U737_19810 ENOG410692J cytochrome C, class I U737_19815 ENOG4105F64 nitrite reductase U737_19825 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) U737_19830 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) U737_19835 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) U737_19840 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) U737_19845 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) U737_19850 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) U737_19855 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) U737_19945 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) U737_19975 ENOG4107R88 Chemotaxis protein (CheV) U737_19980 ENOG4105BZU Histidine kinase U737_19985 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) U737_19990 ENOG4108ZC9 flagellar basal-body rod protein flgc U737_19995 ENOG4105W00 Flagellar hook capping protein U737_20000 ENOG4105BZE flagellar hook protein, FlgE U737_20005 ENOG4108KPB Flagellar basal-body rod protein FlgF U737_20010 ENOG4105CGA flagellar basal-body rod protein FlgG U737_20015 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) U737_20020 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) U737_20025 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj U737_20030 ENOG4105E1Q flagellar hook-associated protein U737_20035 ENOG4105DTJ flagellar hook-associated protein U737_20070 ENOG4108UR2 Nitrogen fixation protein NifX U737_20075 ENOG4105E0F Histidine kinase U737_20085 ENOG4105BZU Histidine kinase U737_20090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family U737_20095 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) U737_20100 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate U737_20105 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) U737_20170 ENOG4105CM2 brancheD-chain amino acid aminotransferase U737_20175 ENOG4105XA0 heptosyltransferase ii U737_20180 ENOG4105D16 lipopolysaccharide heptosyltransferase i U737_20190 ENOG4105DHT Metal Dependent Phosphohydrolase U737_20210 ENOG4105BZS acriflavin resistance protein U737_20220 ENOG4105BZU Histidine kinase U737_20230 ENOG4105DHT Metal Dependent Phosphohydrolase U737_20235 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) U737_20240 ENOG4105D0B Nitrogenase protein alpha chain U737_20245 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain U737_20250 ENOG41084IN nitrogen fixation protein U737_20260 ENOG4105FZE dinitrogenase iron-molybdenum cofactor biosynthesis U737_20305 ENOG4107QHF type ii secretion system protein e U737_20315 ENOG4105W8B Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) U737_20325 ENOG4105E07 UPF0149 protein U737_20330 ENOG4107RAQ aminopeptidase U737_20335 ENOG4105D0A hydroxylase U737_20375 ENOG4105CNM Receptor U737_20385 ENOG4108SF5 RNA Polymerase U737_20405 ENOG4105C37 (CBS) domain U737_20415 ENOG4105WMJ Positive regulator of sigma E, RseC MucC U737_20425 ENOG4105M2J Glutaredoxin U737_20430 ENOG4108P4H ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) U737_20435 ENOG4108S1R peptidylprolyl cis-trans isomerase U737_20440 ENOG4105XV5 nifz family U737_20445 ENOG410605C May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity) U737_20460 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) U737_20485 ENOG4105C3J Cysteine desulfurase U737_20490 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins U737_20495 ENOG4105QAS Iron-sulfur cluster assembly accessory protein U737_20505 ENOG4105D05 Receptor U737_20525 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) U737_20530 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins U737_20540 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) U737_20555 ENOG4105CJ3 phosphate transporter U737_20565 ENOG4107MKT Stringent starvation protein a U737_20570 ENOG4105KB2 stringent starvation protein b U737_20575 ENOG4108ZCD Transcriptional coactivator pterin dehydratase U737_20585 ENOG4105DCC Formylmethanofuran dehydrogenase subunit A U737_20590 ENOG4105FIE Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) (By similarity) U737_20615 ENOG4105VEQ Cold shock protein U737_20620 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit U737_20640 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) U737_20645 ENOG4105CJR Integral membrane protein (MviN U737_20650 ENOG4105II7 pyrroline-5-carboxylate reductase U737_20655 ENOG4108VIA integral membrane protein U737_20665 ENOG4105CAS nag kinase U737_20675 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) U737_20690 ENOG4105E4C Lytic transglycosylase catalytic U737_20695 ENOG4105BZU Histidine kinase U737_20700 ENOG4105F0N pyrophosphate phospho-hydrolase U737_20715 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) U737_20720 ENOG4105CDU Replicative dna helicase U737_20740 ENOG4105DHT Metal Dependent Phosphohydrolase U737_20755 ENOG4108IJF Heavy metal efflux pump, CzcA U737_20765 ENOG4105C8H hydrogenase maturation protein Hypf U737_20780 ENOG4105YES addiction module antidote protein U737_20785 ENOG4105VUH addiction module killer protein U737_20805 ENOG4105CQS hydrogenase expression formation protein HypD U737_20830 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) U737_20840 ENOG410631X Hydrogenase expression formation protein U737_20845 ENOG4107UY0 rubredoxin U737_20880 ENOG4105YYZ Hydrogenase expression formation protein U737_20885 ENOG4105X9Y Hydrogenase assembly chaperone hypC hupF U737_20905 ENOG4105DPX Hydrogenase, large subunit U737_20930 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) U737_20935 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) U737_20945 ENOG4105DXN mazG family U737_20955 ENOG41080IJ Diacylglycerol kinase U737_20960 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) U737_20980 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) U737_20985 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) U737_20995 ENOG4105DN9 Na H antiporter U737_21000 ENOG4105VEQ Cold shock protein U737_21005 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) U737_21010 ENOG4108Z0T Part of a sulfur-relay system (By similarity) U737_21020 ENOG4105KPY Small multidrug resistance protein U737_21025 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) U737_21030 ENOG4108JA2 transcriptioN-repair coupling factor U737_21055 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) U737_21060 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) U737_21070 ENOG4105CPI Metal Dependent Phosphohydrolase U737_21085 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) U737_21110 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) U737_21115 ENOG4105WMR Protein CrcB homolog U737_21120 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) U737_21125 ENOG4105D0M Protease HtpX homolog U737_21130 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) U737_21135 ENOG4105CPP Dehydrogenase, E1 component U737_21140 ENOG4105C7S Dehydrogenase U737_21160 ENOG4107YU2 histidine triad (hIT) protein U737_21165 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) U737_21170 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) U737_21175 ENOG4107QMP dna polymerase iii subunits gamma and tau U737_21185 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) U737_21190 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) U737_21195 ENOG4105EI2 Pseudouridine synthase U737_21200 ENOG4105C03 ribonuclease U737_21210 ENOG4105DWY Agmatine deiminase U737_21230 ENOG4105D7D AAA ATPase U737_21330 ENOG4105EWA aspartate glutamate uridylate kinase U737_21335 ENOG4107YCI aspartate glutamate uridylate kinase U737_21345 ENOG4105D5K Hemolysin activator protein U737_21365 ENOG4105SG9 biopolymer transport protein, ExbD U737_21370 ENOG4105E02 MotA TolQ exbB proton channel U737_21415 ENOG4105DNZ Alpha Beta Hydrolase U737_21440 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) U737_21445 ENOG4105N1F Hnh endonuclease U737_21450 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) U737_21455 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related U737_21460 ENOG4105BZU Histidine kinase U737_21465 ENOG4105GVF (ABC) transporter U737_21480 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein U737_21485 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) U737_21490 ENOG4105C8V SAICAR synthetase U737_21500 ENOG4107RNH Outer membrane receptor FepA U737_21500 ENOG4107RNH Outer membrane receptor FepA U737_21515 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) U737_21520 ENOG4107QMS site-determining protein U737_21525 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) U737_21530 ENOG4105CJW magnesium transporter U737_21535 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) U737_21540 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA U737_21545 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) U737_21550 ENOG4108IUZ ABC transporter U737_21555 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA U737_21565 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase U737_21570 ENOG4105C2X Arabinose 5-phosphate isomerase U737_21575 ENOG4105DHJ ABC, transporter U737_21580 ENOG4105CY3 ABC transporter, permease U737_21585 ENOG4107PE3 Mammalian cell entry related domain protein U737_21595 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) U737_21600 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) U737_21605 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) U737_21655 ENOG4105C5Q Transcriptional regulator U737_21665 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_21670 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase U737_21695 ENOG4105BZU Histidine kinase U737_21700 ENOG4105BZU Histidine kinase U737_21720 ENOG4105E3B Multicopper oxidase U737_21725 ENOG4108VCT Sulfite exporter TauE/SafE U737_21730 ENOG4107TPS domain protein U737_21735 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family U737_21745 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) U737_21750 ENOG4108Q71 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) U737_21755 ENOG4105EXC Acyl-transferase U737_21765 ENOG4107T8V it plays a direct role in the translocation of protons across the membrane (By similarity) U737_21785 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) U737_21800 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) U737_21810 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) U737_21815 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP U737_21825 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) U737_21830 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) U737_21840 ENOG4105VCC 30S ribosomal protein S21 U737_21845 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) U737_21850 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) U737_21855 ENOG4107ZVW dihydroneopterin aldolase U737_21860 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase U737_21865 ENOG4105CHR reductase U737_21895 ENOG4105CV1 Transketolase (EC 2.2.1.1) U737_21905 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase U737_21910 ENOG4108HGY Proline imino-peptidase U737_21920 ENOG4105MWK D-amino acid dehydrogenase, small subunit U737_21930 ENOG4105E3A (ABC) transporter U737_21935 ENOG4105DA5 (ABC) transporter U737_21960 ENOG4105E1F short-chain dehydrogenase reductase U737_21965 ENOG4107YPT transcriptional regulator U737_21985 ENOG4105CMS peptidase U62, modulator of DNA gyrase U737_21990 ENOG4105D1U peptidase U62 modulator of DNA gyrase U737_22000 ENOG4105D6S protein involved in catabolism of external DNA U737_22010 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate U737_22015 ENOG4105HF0 Membrane U737_22025 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) U737_22040 ENOG4105WF7 pyrroloquinoline quinone biosynthesis protein d U737_22045 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E U737_22050 ENOG4105BZ1 (ABC) transporter U737_22055 ENOG4105DKP glycosyl transferase, family 9 U737_22070 ENOG4106WTF Glycosyl transferase, family 2 U737_22085 ENOG4105YFD chemotaxis, protein U737_22095 ENOG4107QJE Chromosome Partitioning Protein U737_22100 ENOG4106VK6 Flagellar motor protein U737_22105 ENOG4105E14 MotA TolQ exbB proton channel U737_22115 ENOG4105CBS Chea signal transduction histidine kinase U737_22120 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) U737_22125 ENOG4108VYJ response regulator receiver protein U737_22130 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) U737_22140 ENOG4105FZW flagellar biosynthesis regulator FlhF U737_22145 ENOG4105D7B Flagellar biosynthesis protein flha U737_22150 ENOG4105D00 flagellar biosynthetic protein flhB U737_22155 ENOG4105D19 Role in flagellar biosynthesis (By similarity) U737_22160 ENOG4105VS8 Flagellar biosynthetic protein fliq U737_22165 ENOG4105CN7 Flagellar biosynthetic protein FliP U737_22170 ENOG4105VTB flagellar biosynthesis protein fliO U737_22175 ENOG4105DD5 Flagellar motor switch protein U737_22180 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) U737_22185 ENOG4105X6C Flagellar basal body-associated protein FliL U737_22190 ENOG4105D2N Aldolase U737_22195 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) U737_22205 ENOG4105CV1 Transketolase (EC 2.2.1.1) U737_22215 ENOG4107XID 2'-5' rna ligase U737_22225 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein U737_22230 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) U737_22235 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) U737_22240 ENOG4105E3I toluene tolerance U737_22245 ENOG4105D52 delta-aminolevulinic acid dehydratase U737_22255 ENOG4105E2X shikimate dehydrogenase U737_22275 ENOG4105DGW oligopeptidase A U737_22390 ENOG4105CNA YD repeat protein U737_22405 ENOG4105CNA YD repeat protein U737_22410 ENOG4105CS6 Rhs element vgr protein U737_22450 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit U737_22495 ENOG4108ZF3 Phosphatase U737_22505 ENOG4106VK6 Flagellar motor protein U737_22525 ENOG4108P7H monooxygenase, subunit B U737_22530 ENOG4105E7Z methane monooxygenase ammonia monooxygenase subunit A U737_22540 ENOG4105M2J Glutaredoxin U737_22580 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) U737_22585 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) U737_22595 ENOG4105E4G Type IV pilus U737_22620 ENOG4108JQC penicillin-binding protein 1A U737_22625 ENOG4105VFB Binds the 23S rRNA (By similarity) U737_22630 ENOG4105EYM Major Facilitator superfamily U737_22635 ENOG4105DN9 Na H antiporter U737_22650 ENOG4105CN1 protease U737_22655 ENOG41063SB peptidase U737_22660 ENOG41080HT Transcriptional regulator, arsr family U737_22670 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) U737_22675 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase U737_22680 ENOG4108V6E Cell division protein mraZ U737_22685 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) U737_22690 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) U737_22695 ENOG4105CJN penicillin-binding protein U737_22700 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) U737_22705 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) U737_22710 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) U737_22715 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) U737_22720 ENOG4105CNI cell division protein FtsW U737_22725 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) U737_22730 ENOG4105DFU Cell wall formation (By similarity) U737_22735 ENOG4105D4A Cell wall formation (By similarity) U737_22740 ENOG4105CPF Cell wall formation (By similarity) U737_22745 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) U737_22750 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) U737_22755 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) U737_22760 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) U737_22790 ENOG4105CUB amino acid U737_22815 ENOG4105C6Y Udp-glucose 6-dehydrogenase U737_22820 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase U737_22825 ENOG4108UJV acyl-CoA thioesterase i U737_22830 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) U737_22835 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) U737_22840 ENOG4105BZU Histidine kinase U737_22850 ENOG4105UYK outer membrane protein a U737_22870 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) U737_22905 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) U737_22920 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) U737_22925 ENOG4108M8S permease YjgP YjgQ family protein U737_22950 ENOG4105DJ0 Poly(A) Polymerase U737_22955 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase U737_22960 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) U737_22965 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) U737_22970 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) U737_22975 ENOG41085EG Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) U737_22980 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) U737_22990 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) U737_22995 ENOG4105EFT decarboxylase U737_23010 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) U737_23015 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) U737_23035 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) U737_23050 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane U737_23055 ENOG4105C34 Pseudouridine synthase U737_23060 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase U737_23075 ENOG4108IUS Transketolase U737_23085 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) U737_23090 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) U737_23095 ENOG41082RQ UPF0102 protein U737_23100 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) U737_23105 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) U737_23115 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase U737_23120 ENOG4105BZU Histidine kinase U737_23130 ENOG4105C3R Methionine synthase U737_23155 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase U737_23160 ENOG4105C38 Glycyl-tRNA synthetase beta subunit U737_23165 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit U737_23190 ENOG4105DN3 alpha-2-macroglobulin domain protein U737_23230 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase U737_23235 ENOG4105D05 Receptor U737_23245 ENOG4108UTW Plays a role in the regulation of phosphate uptake U737_23250 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) U737_23255 ENOG4105E2Z phosphate ABC transporter (Permease U737_23260 ENOG4105C8U phosphate abc transporter U737_23270 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) U737_23275 ENOG4105HDK L-asparaginase U737_23290 ENOG4105C75 arginyL-tRNA synthetase U737_23295 ENOG4105DFA alanine racemase domain protein U737_23300 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) U737_23305 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) U737_23310 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) U737_23315 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase U737_23320 ENOG4105CC0 LysR family Transcriptional regulator U737_23340 ENOG4107TSN permease U737_23375 ENOG4107RH7 Nicotinate phosphoribosyltransferase U737_23390 ENOG4105VRT cytoplasmic protein U737_23400 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase U737_23430 ENOG4107GFK fumarate U737_23455 ENOG4105CEP NADH dehydrogenase U737_23480 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) U737_23490 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) U737_23520 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) U737_23530 ENOG4105K4H Nlp p60 protein U737_23535 ENOG4108RCM Nitroreductase U737_23545 ENOG4105C25 Primosomal protein n' U737_23550 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) U737_23555 ENOG4105Q9Y Universal stress protein U737_23570 ENOG4107SVH Potassium channel protein U737_23575 ENOG4105EMU Dehydrogenase U737_23595 ENOG4108URH decarboxylase U737_23600 ENOG4105DTN riboflavin biosynthesis protein ribF U737_23615 ENOG4108IG5 Transcriptional regulator U737_23620 ENOG4105IU3 Glutathione S-transferase U737_23625 ENOG4108S3I UPF0259 membrane protein U737_23640 ENOG4105C7R Atpase associated with various cellular activities aaa_3 U737_23660 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) U737_23665 ENOG41080ZE Adenylate cyclase U737_23675 ENOG4105BZU Histidine kinase U737_23695 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) U737_23700 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) U737_23705 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) U737_23710 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) U737_23715 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) U737_23720 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) U737_23725 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) U737_23730 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) U737_23740 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) U737_23750 ENOG4105FA0 parb-like partition protein U737_23755 ENOG4107QJE Chromosome Partitioning Protein U737_23760 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) U737_23780 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) U737_23790 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) U737_23795 ENOG4105DAN ATP-dependent protease U737_23805 ENOG4108VYJ response regulator receiver protein U737_23830 ENOG4105CFG Acts as a chaperone (By similarity) U737_23840 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) U737_23860 ENOG4105CV8 reductase U737_23865 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) U737_23875 ENOG4105BZU Histidine kinase U737_23880 ENOG4108RH0 Crea protein U737_23920 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) U737_23925 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family U737_23935 ENOG4105CHP RNA polymerase U737_23960 ENOG4105GRZ Ycii-related protein U737_23975 ENOG4105GRZ Ycii-related protein U737_24000 ENOG4105CS1 NAD(P)H quinone oxidoreductase U737_24005 ENOG4105K89 arsenate reductase U737_24010 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) U737_24025 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) U737_24030 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) U737_24055 ENOG4105CA0 peroxidase U737_24060 ENOG4105CGY Dna recombination protein U737_24090 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase U737_24100 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity)