locus-tag	class	description
GNX18_00010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GNX18_00105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GNX18_00115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GNX18_00135	COG0174	glutamine synthetase
GNX18_00140	COG0205	6-phosphofructokinase activity
GNX18_00145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GNX18_00170	COG3028	Belongs to the UPF0307 family
GNX18_00175	COG2239	Acts as a magnesium transporter
GNX18_00180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNX18_00185	COG1660	Displays ATPase and GTPase activities
GNX18_00205	COG1137	ATPase activity
GNX18_00210	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GNX18_00220	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GNX18_00235	COG0271	Belongs to the BolA IbaG family
GNX18_00240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GNX18_00245	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GNX18_00250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GNX18_00255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GNX18_00260	COG2046	Belongs to the sulfate adenylyltransferase family
GNX18_00270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GNX18_00275	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GNX18_00280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GNX18_00290	COG0723	plastoquinol--plastocyanin reductase activity
GNX18_00295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GNX18_00300	COG0625	glutathione transferase activity
GNX18_00305	COG2969	positive regulation of protein catabolic process
GNX18_00315	COG0501	Belongs to the peptidase M48B family
GNX18_00320	COG1704	LemA family
GNX18_00325	COG0183	Belongs to the thiolase family
GNX18_00335	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GNX18_00340	COG0792	nuclease activity
GNX18_00365	COG2001	Belongs to the MraZ family
GNX18_00370	COG0275	rRNA processing
GNX18_00385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GNX18_00390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GNX18_00395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GNX18_00400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GNX18_00405	COG0772	Belongs to the SEDS family
GNX18_00410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GNX18_00415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GNX18_00430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GNX18_00435	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GNX18_00440	COG0739	heme binding
GNX18_00445	COG0653	protein targeting
GNX18_00455	COG0494	nUDIX hydrolase
GNX18_00485	COG2205	protein histidine kinase activity
GNX18_00490	COG3447	MASE1 domain protein
GNX18_00490	COG5001	Diguanylate cyclase
GNX18_00490	COG5002	protein histidine kinase activity
GNX18_00525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GNX18_00545	COG0105	UTP biosynthetic process
GNX18_00550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GNX18_00565	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GNX18_00570	COG0124	histidyl-tRNA synthetase
GNX18_00575	COG2976	Protein conserved in bacteria
GNX18_00580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GNX18_00585	COG1160	GTP binding
GNX18_00600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNX18_00620	COG0237	dephospho-CoA kinase activity
GNX18_00625	COG3093	addiction module antidote protein HigA
GNX18_00650	COG4969	Belongs to the N-Me-Phe pilin family
GNX18_00740	COG2827	Endonuclease containing a URI domain
GNX18_00755	COG0717	Belongs to the dCTP deaminase family
GNX18_00760	COG2081	HI0933 family
GNX18_00775	COG3530	Putative quorum-sensing-regulated virulence factor
GNX18_00835	COG0737	Belongs to the 5'-nucleotidase family
GNX18_00865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GNX18_00870	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GNX18_00880	COG1309	transcriptional regulator
GNX18_00885	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GNX18_00895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GNX18_00900	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GNX18_00905	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GNX18_00910	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GNX18_00930	COG0402	S-adenosylhomocysteine deaminase activity
GNX18_00935	COG2351	hydroxyisourate hydrolase activity
GNX18_00955	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GNX18_00960	COG2252	PERMEase
GNX18_00975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GNX18_00995	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GNX18_01000	COG1053	succinate dehydrogenase
GNX18_01005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GNX18_01025	COG0045	succinate-CoA ligase (ADP-forming) activity
GNX18_01050	COG3795	YCII-related domain
GNX18_01055	COG4941	Belongs to the sigma-70 factor family
GNX18_01060	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GNX18_01065	COG0709	Synthesizes selenophosphate from selenide and ATP
GNX18_01080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GNX18_01090	COG0288	reversible hydration of carbon dioxide
GNX18_01130	COG1982	Orn Lys Arg decarboxylase major
GNX18_01135	COG4774	siderophore transport
GNX18_01165	COG2832	Protein of unknown function (DUF454)
GNX18_01170	COG3279	Response regulator of the LytR AlgR family
GNX18_01185	COG1960	acyl-CoA dehydrogenase activity
GNX18_01210	COG0348	domain, Protein
GNX18_01215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GNX18_01230	COG2259	Doxx family
GNX18_01235	COG0583	DNA-binding transcription factor activity
GNX18_01260	COG2207	Transcriptional regulator
GNX18_01270	COG0673	inositol 2-dehydrogenase activity
GNX18_01295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GNX18_01310	COG3039	Transposase
GNX18_01315	COG3328	transposase activity
GNX18_01330	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_01335	COG0129	dihydroxy-acid dehydratase activity
GNX18_01340	COG2211	Major facilitator Superfamily
GNX18_01345	COG3408	Glycogen debranching enzyme
GNX18_01360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GNX18_01380	COG1472	Belongs to the glycosyl hydrolase 3 family
GNX18_01385	COG3940	Belongs to the glycosyl hydrolase 43 family
GNX18_01390	COG3940	Belongs to the glycosyl hydrolase 43 family
GNX18_01410	COG2723	6-phospho-beta-galactosidase activity
GNX18_01425	COG1960	acyl-CoA dehydrogenase activity
GNX18_01430	COG0800	Aldolase
GNX18_01445	COG3347	Dehydrogenase
GNX18_01445	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_01450	COG4952	isomerase
GNX18_01520	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GNX18_01530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GNX18_01535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GNX18_01540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GNX18_01555	COG2906	2 iron, 2 sulfur cluster binding
GNX18_01560	COG0450	alkyl hydroperoxide reductase
GNX18_01570	COG0326	Molecular chaperone. Has ATPase activity
GNX18_01575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GNX18_01600	COG3710	Transcriptional regulator
GNX18_01620	COG0366	Alpha amylase catalytic
GNX18_01635	COG0302	gtp cyclohydrolase
GNX18_01640	COG2890	protein-(glutamine-N5) methyltransferase activity
GNX18_01645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GNX18_01660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GNX18_01665	COG0066	3-isopropylmalate dehydratase activity
GNX18_01670	COG0473	3-isopropylmalate dehydrogenase activity
GNX18_01695	COG0135	phosphoribosylanthranilate isomerase activity
GNX18_01705	COG0159	tryptophan synthase activity
GNX18_01710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GNX18_01715	COG0285	dihydrofolate synthase activity
GNX18_01725	COG1286	toxin biosynthetic process
GNX18_01740	COG0714	Associated with various cellular activities
GNX18_01770	COG0366	Alpha amylase catalytic
GNX18_01775	COG1215	transferase activity, transferring glycosyl groups
GNX18_01790	COG0616	signal peptide processing
GNX18_01805	COG1393	Belongs to the ArsC family
GNX18_01810	COG1295	ribonuclease BN
GNX18_01815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNX18_01835	COG0745	RESPONSE REGULATOR receiver
GNX18_01840	COG2205	protein histidine kinase activity
GNX18_01855	COG1960	acyl-CoA dehydrogenase activity
GNX18_01885	COG0730	response to heat
GNX18_01890	COG2827	Endonuclease containing a URI domain
GNX18_01895	COG0640	Transcriptional regulator
GNX18_01905	COG0798	PFAM Bile acid sodium symporter
GNX18_01910	COG0431	NADPH-dependent FMN reductase
GNX18_01920	COG0070	glutamate synthase
GNX18_01920	COG0067	glutamate synthase
GNX18_01920	COG0069	glutamate synthase activity
GNX18_01925	COG0025	NhaP-type Na H and K H
GNX18_01940	COG1063	alcohol dehydrogenase
GNX18_01965	COG0443	Heat shock 70 kDa protein
GNX18_01975	COG0259	pyridoxamine-phosphate oxidase activity
GNX18_01980	COG1960	acyl-CoA dehydrogenase activity
GNX18_01985	COG1960	acyl-CoA dehydrogenase activity
GNX18_01990	COG4771	TonB-dependent receptor
GNX18_01995	COG0604	alcohol dehydrogenase
GNX18_01995	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_01995	COG3321	synthase
GNX18_02000	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GNX18_02005	COG1570	exodeoxyribonuclease VII activity
GNX18_02015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GNX18_02015	COG0519	Catalyzes the synthesis of GMP from XMP
GNX18_02020	COG0596	Alpha beta hydrolase
GNX18_02035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GNX18_02110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GNX18_02115	COG1982	Orn Lys Arg decarboxylase major
GNX18_02130	COG4572	Cation transport regulator
GNX18_02160	COG1178	ABC-type Fe3 transport system permease component
GNX18_02165	COG3842	ATPase activity
GNX18_02170	COG2885	chlorophyll binding
GNX18_02175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GNX18_02185	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GNX18_02200	COG2350	Protein conserved in bacteria
GNX18_02210	COG0613	PHP domain protein
GNX18_02215	COG0009	L-threonylcarbamoyladenylate synthase
GNX18_02225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GNX18_02240	COG2205	protein histidine kinase activity
GNX18_02245	COG0745	RESPONSE REGULATOR receiver
GNX18_02265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GNX18_02270	COG2171	N-acyltransferase activity
GNX18_02275	COG1393	Belongs to the ArsC family
GNX18_02280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GNX18_02285	COG0436	Aminotransferase
GNX18_02290	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GNX18_02295	COG0024	Methionine aminopeptidase
GNX18_02300	COG0052	Belongs to the universal ribosomal protein uS2 family
GNX18_02305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GNX18_02310	COG0528	UMP kinase activity
GNX18_02315	COG0233	cytoplasmic translational termination
GNX18_02320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GNX18_02330	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GNX18_02340	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GNX18_02355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GNX18_02360	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GNX18_02365	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GNX18_02370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GNX18_02375	COG4536	flavin adenine dinucleotide binding
GNX18_02380	COG4137	Cytochrome C assembly protein
GNX18_02385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GNX18_02390	COG0228	four-way junction DNA binding
GNX18_02395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GNX18_02400	COG0336	Belongs to the RNA methyltransferase TrmD family
GNX18_02405	COG0335	large ribosomal subunit rRNA binding
GNX18_02410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GNX18_02425	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GNX18_02435	COG1280	lysine exporter protein (LysE YggA)
GNX18_02450	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GNX18_02460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GNX18_02465	COG2267	carboxylic ester hydrolase activity
GNX18_02470	COG2835	tetraacyldisaccharide 4'-kinase activity
GNX18_02475	COG0537	adenosine 5'-monophosphoramidase activity
GNX18_02480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GNX18_02485	COG0527	aspartate kinase activity
GNX18_02490	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GNX18_02530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GNX18_02535	COG0343	queuine tRNA-ribosyltransferase activity
GNX18_02545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GNX18_02560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GNX18_02565	COG0418	dihydroorotase activity
GNX18_02570	COG0137	argininosuccinate synthase activity
GNX18_02575	COG3278	Belongs to the heme-copper respiratory oxidase family
GNX18_02590	COG2010	Cytochrome c
GNX18_02635	COG0463	Glycosyl transferase, family 2
GNX18_02655	COG3023	N-Acetylmuramoyl-L-alanine amidase
GNX18_02660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GNX18_02670	COG1881	PFAM PEBP family protein
GNX18_02680	COG3695	enzyme binding
GNX18_02690	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_02695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GNX18_02705	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GNX18_02710	COG0459	protein refolding
GNX18_02795	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GNX18_02795	COG1796	DNA polymerase
GNX18_02805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GNX18_02810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GNX18_02820	COG0511	ligase activity, forming carbon-carbon bonds
GNX18_02820	COG5016	pyruvate
GNX18_02825	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GNX18_02830	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GNX18_02835	COG0271	Belongs to the BolA IbaG family
GNX18_02840	COG3047	cAMP biosynthetic process
GNX18_02850	COG0789	Transcriptional regulator
GNX18_02860	COG0514	ATP-dependent DNA helicase (RecQ)
GNX18_02885	COG0716	FMN binding
GNX18_02890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GNX18_02905	COG3089	Belongs to the UPF0270 family
GNX18_02920	COG0425	Belongs to the sulfur carrier protein TusA family
GNX18_02930	COG3101	peptidyl-lysine hydroxylation
GNX18_02935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GNX18_02935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GNX18_02940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GNX18_02960	COG0436	Aminotransferase
GNX18_02965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GNX18_02995	COG1131	(ABC) transporter
GNX18_03000	COG0842	Transport permease protein
GNX18_03005	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GNX18_03005	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GNX18_03040	COG4677	pectinesterase activity
GNX18_03050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GNX18_03065	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GNX18_03080	COG1666	GTP binding
GNX18_03090	COG1573	uracil-dna glycosylase
GNX18_03095	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GNX18_03105	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GNX18_03135	COG3086	response to oxidative stress
GNX18_03140	COG4948	Mandelate Racemase Muconate Lactonizing
GNX18_03145	COG2866	Carboxypeptidase
GNX18_03150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GNX18_03155	COG0481	GTPase activity
GNX18_03170	COG0571	ribonuclease III activity
GNX18_03175	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GNX18_03180	COG1381	Involved in DNA repair and RecF pathway recombination
GNX18_03185	COG0784	Response regulator, receiver
GNX18_03185	COG5002	protein histidine kinase activity
GNX18_03185	COG2205	protein histidine kinase activity
GNX18_03195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GNX18_03200	COG3956	TIGRFAM MazG family protein
GNX18_03205	COG0563	adenylate kinase activity
GNX18_03210	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GNX18_03225	COG1968	undecaprenyl-diphosphatase activity
GNX18_03230	COG2084	Dehydrogenase
GNX18_03235	COG0438	transferase activity, transferring glycosyl groups
GNX18_03265	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GNX18_03275	COG2974	May be involved in recombination
GNX18_03290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GNX18_03295	COG2195	Cleaves the N-terminal amino acid of tripeptides
GNX18_03300	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GNX18_03320	COG2968	Membrane
GNX18_03330	COG0346	lactoylglutathione lyase activity
GNX18_03350	COG4242	Belongs to the peptidase S51 family
GNX18_03355	COG4206	TonB-dependent receptor
GNX18_03360	COG1288	antiporter activity
GNX18_03365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GNX18_03385	COG0174	glutamine synthetase
GNX18_03395	COG0438	transferase activity, transferring glycosyl groups
GNX18_03415	COG0110	maltose O-acetyltransferase activity
GNX18_03420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GNX18_03425	COG1522	sequence-specific DNA binding
GNX18_03450	COG0438	transferase activity, transferring glycosyl groups
GNX18_03460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GNX18_03475	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GNX18_03490	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_03500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GNX18_03505	COG0402	S-adenosylhomocysteine deaminase activity
GNX18_03515	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GNX18_03520	COG0077	Prephenate dehydratase
GNX18_03520	COG1605	Chorismate mutase
GNX18_03525	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GNX18_03530	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GNX18_03540	COG0776	regulation of translation
GNX18_03550	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GNX18_03555	COG0284	orotidine-5'-phosphate decarboxylase activity
GNX18_03560	COG1555	photosystem II stabilization
GNX18_03570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GNX18_03590	COG0556	nucleotide-excision repair
GNX18_03605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GNX18_03610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GNX18_03615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GNX18_03620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GNX18_03625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GNX18_03635	COG0776	regulation of translation
GNX18_03665	COG1690	Belongs to the RtcB family
GNX18_03705	COG0513	Belongs to the DEAD box helicase family
GNX18_03725	COG0789	Transcriptional regulator
GNX18_03730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GNX18_03735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GNX18_03755	COG1842	Phage shock protein A
GNX18_03775	COG5463	Belongs to the UPF0441 family
GNX18_03780	COG0754	glutathionylspermidine amidase activity
GNX18_03790	COG3012	SEC-C Motif Domain Protein
GNX18_03805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GNX18_03810	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GNX18_03850	COG0625	glutathione transferase activity
GNX18_03860	COG1448	Aminotransferase
GNX18_03865	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GNX18_03875	COG0339	signal peptide processing
GNX18_03885	COG1522	sequence-specific DNA binding
GNX18_03900	COG1595	DNA-templated transcription, initiation
GNX18_03910	COG4221	oxidoreductase activity
GNX18_03925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GNX18_03945	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GNX18_03945	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GNX18_03945	COG0506	proline dehydrogenase activity
GNX18_03975	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GNX18_03990	COG1881	PFAM PEBP family protein
GNX18_04010	COG1115	amino acid carrier protein
GNX18_04025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GNX18_04035	COG2900	Belongs to the SlyX family
GNX18_04060	COG0742	ribosomal rna small subunit methyltransferase
GNX18_04065	COG1760	l-serine dehydratase
GNX18_04070	COG0500	methyltransferase
GNX18_04075	COG4106	trans-aconitate 2-methyltransferase activity
GNX18_04090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GNX18_04110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GNX18_04130	COG1960	acyl-CoA dehydrogenase activity
GNX18_04135	COG1538	Outer membrane efflux protein
GNX18_04150	COG4651	solute:proton antiporter activity
GNX18_04150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GNX18_04160	COG1522	sequence-specific DNA binding
GNX18_04190	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GNX18_04210	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GNX18_04210	COG0316	Belongs to the HesB IscA family
GNX18_04215	COG2342	PFAM TM1410 hypothetical-related protein
GNX18_04235	COG1643	Atp-dependent helicase
GNX18_04245	COG2375	cellular response to nickel ion
GNX18_04250	COG0500	methyltransferase
GNX18_04260	COG2814	Major facilitator Superfamily
GNX18_04345	COG0583	DNA-binding transcription factor activity
GNX18_04350	COG2249	NAD(P)H dehydrogenase (quinone) activity
GNX18_04355	COG4106	trans-aconitate 2-methyltransferase activity
GNX18_04420	COG0745	RESPONSE REGULATOR receiver
GNX18_04460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GNX18_04480	COG1322	Protein conserved in bacteria
GNX18_04495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GNX18_04510	COG0432	Pfam Uncharacterised protein family UPF0047
GNX18_04520	COG1012	belongs to the aldehyde dehydrogenase family
GNX18_04525	COG1309	transcriptional regulator
GNX18_04530	COG0251	oxidation-reduction process
GNX18_04540	COG2920	part of a sulfur-relay system
GNX18_04560	COG0670	Belongs to the BI1 family
GNX18_04585	COG0398	Pfam SNARE associated Golgi protein
GNX18_04610	COG1335	isochorismatase
GNX18_04620	COG1530	ribonuclease E activity
GNX18_04635	COG1399	metal-binding, possibly nucleic acid-binding protein
GNX18_04640	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GNX18_04645	COG0416	fatty acid biosynthetic process
GNX18_04650	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GNX18_04660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNX18_04665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GNX18_04675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GNX18_04680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GNX18_04695	COG0084	hydrolase, TatD family'
GNX18_04705	COG0039	L-malate dehydrogenase activity
GNX18_04710	COG0017	Asparaginyl-tRNA synthetase
GNX18_04720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GNX18_04730	COG1862	Preprotein translocase
GNX18_04735	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GNX18_04740	COG1115	amino acid carrier protein
GNX18_04745	COG0174	glutamine synthetase
GNX18_04750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GNX18_04755	COG4771	TonB-dependent receptor
GNX18_04760	COG3226	Transcriptional regulator
GNX18_04805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GNX18_04820	COG0427	acetyl-CoA hydrolase
GNX18_04825	COG0280	phosphate acetyltransferase
GNX18_04825	COG0857	belongs to the CobB CobQ family
GNX18_04830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GNX18_04835	COG4447	cellulose binding
GNX18_04835	COG3291	Pkd domain containing protein
GNX18_04835	COG5520	Belongs to the glycosyl hydrolase 30 family
GNX18_04855	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GNX18_04865	COG0642	Histidine kinase
GNX18_04870	COG0745	RESPONSE REGULATOR receiver
GNX18_04885	COG2850	peptidyl-arginine hydroxylation
GNX18_04895	COG2915	High frequency lysogenization protein hflD homolog
GNX18_04915	COG1278	Cold shock
GNX18_04920	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GNX18_04925	COG0542	response to heat
GNX18_04930	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GNX18_04935	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GNX18_04940	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GNX18_04945	COG0492	ferredoxin-NADP+ reductase activity
GNX18_04950	COG1674	ftsk spoiiie
GNX18_04955	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GNX18_04960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GNX18_04965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GNX18_04970	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GNX18_04975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GNX18_04975	COG1648	precorrin-2 dehydrogenase activity
GNX18_04990	COG4771	TonB-dependent receptor
GNX18_04995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GNX18_05010	COG0429	hydrolase of the alpha beta-hydrolase fold
GNX18_05045	COG1607	acyl-coa hydrolase
GNX18_05060	COG0309	Hydrogenase expression formation protein (HypE)
GNX18_05070	COG0298	carbon dioxide binding
GNX18_05075	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GNX18_05100	COG0543	2 iron, 2 sulfur cluster binding
GNX18_05130	COG0071	Belongs to the small heat shock protein (HSP20) family
GNX18_05135	COG3459	Glycosyltransferase 36 associated
GNX18_05145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GNX18_05145	COG0574	Belongs to the PEP-utilizing enzyme family
GNX18_05200	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GNX18_05210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GNX18_05215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GNX18_05220	COG1309	transcriptional regulator
GNX18_05225	COG0793	Belongs to the peptidase S41A family
GNX18_05230	COG0708	Exodeoxyribonuclease III
GNX18_05340	COG1946	Acyl-CoA thioesterase
GNX18_05380	COG0322	excinuclease ABC activity
GNX18_05390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GNX18_05395	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GNX18_05400	COG1663	tetraacyldisaccharide 4'-kinase activity
GNX18_05405	COG1132	(ABC) transporter
GNX18_05410	COG0848	biopolymer transport protein
GNX18_05415	COG0811	peptide transport
GNX18_05420	COG0658	competence protein
GNX18_05420	COG2333	competence protein COMEC
GNX18_05430	COG1944	ATP diphosphatase activity
GNX18_05435	COG0010	Belongs to the arginase family
GNX18_05470	COG2205	protein histidine kinase activity
GNX18_05470	COG0784	Response regulator, receiver
GNX18_05505	COG2079	MmgE PrpD family protein
GNX18_05545	COG0583	DNA-binding transcription factor activity
GNX18_05555	COG1017	nitric oxide dioxygenase activity
GNX18_05555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GNX18_05570	COG0417	DNA replication proofreading
GNX18_05575	COG3973	AAA domain
GNX18_05590	COG5002	protein histidine kinase activity
GNX18_05635	COG0372	Belongs to the citrate synthase family
GNX18_05640	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GNX18_05645	COG1802	Transcriptional regulator
GNX18_05655	COG4591	ABC-type transport system involved in lipoprotein release permease component
GNX18_05665	COG4591	ABC-type transport system involved in lipoprotein release permease component
GNX18_05685	COG2050	protein possibly involved in aromatic compounds catabolism
GNX18_05690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GNX18_05700	COG1477	protein flavinylation
GNX18_05710	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GNX18_05725	COG1805	sodium ion transport
GNX18_05730	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GNX18_05740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GNX18_05755	COG1278	Cold shock
GNX18_05760	COG0668	transmembrane transport
GNX18_05765	COG1472	Belongs to the glycosyl hydrolase 3 family
GNX18_05780	COG1611	Belongs to the LOG family
GNX18_05785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GNX18_05810	COG0589	response to stress
GNX18_05820	COG0741	lytic transglycosylase activity
GNX18_05835	COG0631	protein serine/threonine phosphatase activity
GNX18_05845	COG0116	Belongs to the methyltransferase superfamily
GNX18_05845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GNX18_05850	COG3130	regulation of translation
GNX18_05855	COG0167	dihydroorotate dehydrogenase activity
GNX18_05865	COG0714	Associated with various cellular activities
GNX18_05885	COG2304	oxidoreductase activity
GNX18_05895	COG0438	transferase activity, transferring glycosyl groups
GNX18_05920	COG1368	sulfuric ester hydrolase activity
GNX18_05930	COG0438	transferase activity, transferring glycosyl groups
GNX18_05940	COG1215	transferase activity, transferring glycosyl groups
GNX18_05945	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GNX18_05980	COG0529	Catalyzes the synthesis of activated sulfate
GNX18_06000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GNX18_06005	COG1187	pseudouridine synthase activity
GNX18_06010	COG2813	Specifically methylates the guanine in position
GNX18_06025	COG1956	GAF domain-containing protein
GNX18_06055	COG0215	cysteine-tRNA ligase activity
GNX18_06060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GNX18_06065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GNX18_06070	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GNX18_06075	COG0659	secondary active sulfate transmembrane transporter activity
GNX18_06090	COG0531	amino acid
GNX18_06155	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GNX18_06185	COG3634	alkyl hydroperoxide reductase activity
GNX18_06195	COG3122	Protein conserved in bacteria
GNX18_06205	COG0659	secondary active sulfate transmembrane transporter activity
GNX18_06220	COG0640	Transcriptional regulator
GNX18_06225	COG2391	methyltransferase activity
GNX18_06255	COG0604	alcohol dehydrogenase
GNX18_06260	COG0616	signal peptide processing
GNX18_06270	COG2816	NAD+ diphosphatase activity
GNX18_06280	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GNX18_06285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GNX18_06290	COG0328	RNA-DNA hybrid ribonuclease activity
GNX18_06295	COG2226	methyltransferase
GNX18_06300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNX18_06305	COG0741	lytic transglycosylase activity
GNX18_06305	COG1388	LysM domain
GNX18_06310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GNX18_06320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GNX18_06325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GNX18_06330	COG0740	serine-type endopeptidase activity
GNX18_06335	COG0544	peptidyl-prolyl cis-trans isomerase activity
GNX18_06345	COG0183	Belongs to the thiolase family
GNX18_06350	COG1250	3-hydroxyacyl-CoA dehydrogenase
GNX18_06350	COG1024	Enoyl-CoA hydratase
GNX18_06360	COG4977	sequence-specific DNA binding
GNX18_06360	COG1917	Cupin 2, conserved barrel domain protein
GNX18_06370	COG0071	Belongs to the small heat shock protein (HSP20) family
GNX18_06400	COG3768	UPF0283 membrane protein
GNX18_06405	COG3106	COG3106 Predicted ATPase
GNX18_06425	COG1047	Peptidyl-prolyl cis-trans
GNX18_06430	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GNX18_06440	COG0084	hydrolase, TatD family'
GNX18_06445	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_06455	COG0385	Bile acid
GNX18_06460	COG2072	flavoprotein involved in K transport
GNX18_06470	COG0433	COG0433 Predicted ATPase
GNX18_06485	COG2866	Carboxypeptidase
GNX18_06500	COG0318	PFAM AMP-dependent synthetase and ligase
GNX18_06510	COG1960	acyl-CoA dehydrogenase activity
GNX18_06535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GNX18_06540	COG3115	cell septum assembly
GNX18_06585	COG1739	Uncharacterized protein family UPF0029
GNX18_06600	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GNX18_06615	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GNX18_06620	COG4133	protoheme IX ABC transporter activity
GNX18_06645	COG1446	asparaginase
GNX18_06675	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GNX18_06675	COG2755	lipolytic protein G-D-S-L family
GNX18_06710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GNX18_06715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GNX18_06725	COG1757	Na H antiporter
GNX18_06730	COG1619	proteins homologs of microcin C7 resistance protein MccF
GNX18_06745	COG1737	Transcriptional regulator
GNX18_06750	COG4948	Mandelate Racemase Muconate Lactonizing
GNX18_06765	COG1611	Belongs to the LOG family
GNX18_06770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GNX18_06775	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GNX18_06795	COG1505	serine-type exopeptidase activity
GNX18_06800	COG0471	metal ion transport
GNX18_06810	COG3228	Belongs to the MtfA family
GNX18_06840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GNX18_06860	COG0783	Belongs to the Dps family
GNX18_06880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GNX18_06885	COG0686	Belongs to the AlaDH PNT family
GNX18_06920	COG1397	ADP-ribosylglycohydrolase
GNX18_06945	COG3209	COG3209 Rhs family protein
GNX18_06975	COG3209	COG3209 Rhs family protein
GNX18_06980	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GNX18_06985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GNX18_06990	COG0037	tRNA processing
GNX18_07000	COG4181	ATPase activity
GNX18_07005	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GNX18_07010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GNX18_07020	COG3401	FG-GAP repeat protein
GNX18_07065	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GNX18_07085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GNX18_07105	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_07105	COG3321	synthase
GNX18_07105	COG0604	alcohol dehydrogenase
GNX18_07110	COG0183	Belongs to the thiolase family
GNX18_07115	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_07125	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_07130	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_07155	COG0446	pyridine nucleotide-disulphide oxidoreductase
GNX18_07155	COG1902	pentaerythritol trinitrate reductase activity
GNX18_07160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GNX18_07165	COG2918	glutathione biosynthetic process
GNX18_07165	COG1181	Belongs to the D-alanine--D-alanine ligase family
GNX18_07165	COG0189	ligase activity
GNX18_07175	COG2274	protein secretion by the type I secretion system
GNX18_07195	COG2211	Major facilitator Superfamily
GNX18_07205	COG2272	Belongs to the type-B carboxylesterase lipase family
GNX18_07215	COG0308	aminopeptidase N
GNX18_07220	COG0405	Gamma-glutamyltransferase
GNX18_07235	COG3784	Protein of unknown function (DUF1318)
GNX18_07255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GNX18_07260	COG0585	pseudouridine synthase activity
GNX18_07265	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GNX18_07270	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GNX18_07275	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GNX18_07280	COG0148	phosphopyruvate hydratase activity
GNX18_07290	COG0504	CTP synthase activity
GNX18_07295	COG0037	tRNA processing
GNX18_07300	COG3693	PFAM glycoside hydrolase, family 10
GNX18_07305	COG0477	Major facilitator Superfamily
GNX18_07310	COG1472	Belongs to the glycosyl hydrolase 3 family
GNX18_07320	COG1307	EDD domain protein, DegV family
GNX18_07335	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GNX18_07340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GNX18_07350	COG3119	arylsulfatase activity
GNX18_07490	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GNX18_07495	COG3507	Belongs to the glycosyl hydrolase 43 family
GNX18_07510	COG0277	FAD linked oxidase domain protein
GNX18_07530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GNX18_07535	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GNX18_07555	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GNX18_07555	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GNX18_07575	COG2010	Cytochrome c
GNX18_07580	COG0753	catalase activity
GNX18_07600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GNX18_07605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GNX18_07620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GNX18_07620	COG1116	anion transmembrane transporter activity
GNX18_07625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GNX18_07630	COG1116	anion transmembrane transporter activity
GNX18_07645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GNX18_07655	COG2022	thiamine diphosphate biosynthetic process
GNX18_07660	COG2022	thiamine diphosphate biosynthetic process
GNX18_07660	COG2104	thiamine diphosphate biosynthetic process
GNX18_07675	COG1012	belongs to the aldehyde dehydrogenase family
GNX18_07685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GNX18_07690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GNX18_07695	COG0825	malonyl-CoA metabolic process
GNX18_07715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GNX18_07725	COG0583	DNA-binding transcription factor activity
GNX18_07735	COG2818	Glycosylase
GNX18_07820	COG5265	(ABC) transporter
GNX18_07855	COG2235	arginine
GNX18_07875	COG3118	belongs to the thioredoxin family
GNX18_07890	COG0583	DNA-binding transcription factor activity
GNX18_07905	COG0590	tRNA wobble adenosine to inosine editing
GNX18_07910	COG2226	methyltransferase
GNX18_07935	COG0795	lipopolysaccharide-transporting ATPase activity
GNX18_07940	COG0795	lipopolysaccharide-transporting ATPase activity
GNX18_07945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GNX18_07960	COG0525	valine-tRNA ligase activity
GNX18_07965	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GNX18_07970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GNX18_07975	COG0649	NAD binding
GNX18_07975	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GNX18_07980	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GNX18_07990	COG1034	ATP synthesis coupled electron transport
GNX18_07995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GNX18_08000	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GNX18_08010	COG0713	ATP synthesis coupled electron transport
GNX18_08025	COG1007	ATP synthesis coupled electron transport
GNX18_08040	COG0189	ligase activity
GNX18_08055	COG3098	single-species biofilm formation
GNX18_08060	COG1199	ATP-dependent helicase activity
GNX18_08080	COG0166	Belongs to the GPI family
GNX18_08085	COG3386	PFAM SMP-30 Gluconolaconase
GNX18_08090	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_08100	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GNX18_08105	COG3250	beta-galactosidase activity
GNX18_08110	COG2186	Transcriptional regulator
GNX18_08115	COG0129	dihydroxy-acid dehydratase activity
GNX18_08120	COG3734	2-keto-3-deoxy-galactonokinase
GNX18_08125	COG0800	Aldolase
GNX18_08135	COG0330	HflC and HflK could
GNX18_08170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GNX18_08175	COG1702	phosphate starvation-inducible protein PhoH
GNX18_08185	COG4535	Mg2 and Co2 transporter CorC
GNX18_08195	COG1090	epimerase
GNX18_08215	COG0495	leucyl-tRNA aminoacylation
GNX18_08225	COG1466	dna polymerase III delta subunit
GNX18_08230	COG0436	Aminotransferase
GNX18_08235	COG0154	amidase activity
GNX18_08250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GNX18_08255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GNX18_08270	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GNX18_08285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GNX18_08295	COG2205	protein histidine kinase activity
GNX18_08295	COG0784	Response regulator, receiver
GNX18_08305	COG5297	Belongs to the glycosyl hydrolase family 6
GNX18_08310	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GNX18_08320	COG0823	Involved in the tonB-independent uptake of proteins
GNX18_08320	COG4946	Tricorn protease homolog
GNX18_08320	COG1506	peptidase
GNX18_08325	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GNX18_08330	COG0321	lipoyl(octanoyl) transferase activity
GNX18_08335	COG2921	Belongs to the UPF0250 family
GNX18_08340	COG1686	Belongs to the peptidase S11 family
GNX18_08350	COG2951	lytic endotransglycosylase activity
GNX18_08355	COG0772	Belongs to the SEDS family
GNX18_08360	COG0768	penicillin binding
GNX18_08365	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GNX18_08375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GNX18_08380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GNX18_08395	COG2321	neutral zinc metallopeptidase
GNX18_08400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GNX18_08415	COG1530	ribonuclease E activity
GNX18_08425	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GNX18_08430	COG1792	Involved in formation and maintenance of cell shape
GNX18_08435	COG1077	Cell shape determining protein MreB Mrl
GNX18_08440	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GNX18_08445	COG0154	amidase activity
GNX18_08450	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GNX18_08465	COG3263	regulation of cellular component size
GNX18_08480	COG0534	Mate efflux family protein
GNX18_08495	COG1230	cation diffusion facilitator family transporter
GNX18_08505	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GNX18_08510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GNX18_08520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GNX18_08525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GNX18_08535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GNX18_08540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GNX18_08545	COG0193	aminoacyl-tRNA hydrolase activity
GNX18_08555	COG0697	spore germination
GNX18_08595	COG0469	pyruvate kinase activity
GNX18_08605	COG0800	Aldolase
GNX18_08615	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GNX18_08620	COG0129	dihydroxy-acid dehydratase activity
GNX18_08630	COG0166	Belongs to the GPI family
GNX18_08635	COG1609	Transcriptional regulator
GNX18_08640	COG0738	Major facilitator superfamily
GNX18_08645	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GNX18_08650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GNX18_08655	COG2971	BadF BadG BcrA BcrD
GNX18_08670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GNX18_08675	COG0540	Belongs to the ATCase OTCase family
GNX18_08680	COG2925	Exonuclease
GNX18_08755	COG1917	Cupin 2, conserved barrel domain protein
GNX18_08755	COG2169	Transcriptional regulator
GNX18_08760	COG0018	arginyl-trna synthetase
GNX18_08775	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GNX18_08775	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GNX18_08780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNX18_08805	COG0788	formyltetrahydrofolate deformylase activity
GNX18_08810	COG0006	proline dipeptidase activity
GNX18_08815	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GNX18_08820	COG0583	DNA-binding transcription factor activity
GNX18_08825	COG3128	pkhd-type hydroxylase
GNX18_08830	COG4774	siderophore transport
GNX18_08840	COG0513	Belongs to the DEAD box helicase family
GNX18_08865	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GNX18_08915	COG1216	Glycosyl transferase, family 2
GNX18_08915	COG0438	transferase activity, transferring glycosyl groups
GNX18_08935	COG3754	Rhamnan synthesis protein F
GNX18_08940	COG1088	dTDP-glucose 4,6-dehydratase activity
GNX18_08985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GNX18_08990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GNX18_09060	COG1677	Flagellar hook-basal body complex protein FliE
GNX18_09110	COG3190	flagellar
GNX18_09120	COG1987	bacterial-type flagellum assembly
GNX18_09130	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GNX18_09135	COG1256	bacterial-type flagellum assembly
GNX18_09140	COG1705	Flagellar rod assembly protein muramidase FlgJ
GNX18_09140	COG3951	Flagellar rod assembly protein muramidase FlgJ
GNX18_09145	COG1706	bacterial-type flagellum-dependent cell motility
GNX18_09165	COG1749	Flagellar hook protein flgE
GNX18_09170	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GNX18_09175	COG1558	bacterial-type flagellum-dependent cell motility
GNX18_09190	COG2747	anti-sigma28 factor FlgM
GNX18_09200	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GNX18_09205	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GNX18_09210	COG1191	sigma factor activity
GNX18_09225	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GNX18_09235	COG0840	transmembrane signaling receptor activity
GNX18_09240	COG2201	protein-glutamate methylesterase activity
GNX18_09245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GNX18_09250	COG0840	transmembrane signaling receptor activity
GNX18_09255	COG0835	chemotaxis
GNX18_09260	COG0643	Histidine kinase
GNX18_09260	COG2198	Histidine kinase
GNX18_09265	COG1360	Flagellar Motor Protein
GNX18_09295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GNX18_09300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GNX18_09320	COG2853	Lipoprotein
GNX18_09330	COG3220	belongs to the UPF0276 family
GNX18_09340	COG1643	Atp-dependent helicase
GNX18_09345	COG3104	oligopeptide transport
GNX18_09355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GNX18_09370	COG2983	Belongs to the UPF0260 family
GNX18_09375	COG3100	YcgL domain-containing protein
GNX18_09385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GNX18_09390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GNX18_09400	COG1595	DNA-templated transcription, initiation
GNX18_09415	COG4206	TonB-dependent receptor
GNX18_09425	COG4771	TonB-dependent receptor
GNX18_09440	COG2095	MarC family integral membrane protein
GNX18_09455	COG3104	oligopeptide transport
GNX18_09460	COG0730	response to heat
GNX18_09465	COG1185	polyribonucleotide nucleotidyltransferase activity
GNX18_09470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GNX18_09475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GNX18_09480	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GNX18_09485	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GNX18_09490	COG0195	Participates in both transcription termination and antitermination
GNX18_09495	COG0779	Required for maturation of 30S ribosomal subunits
GNX18_09570	COG0811	peptide transport
GNX18_09605	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GNX18_09610	COG0315	cyclic pyranopterin monophosphate synthase activity
GNX18_09615	COG0521	Mo-molybdopterin cofactor biosynthetic process
GNX18_09620	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GNX18_09625	COG0469	pyruvate kinase activity
GNX18_09635	COG2252	PERMEase
GNX18_09640	COG0217	transcriptional regulatory protein
GNX18_09645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GNX18_09665	COG0464	growth
GNX18_09680	COG0149	triose-phosphate isomerase activity
GNX18_09685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GNX18_09690	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GNX18_09700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GNX18_09710	COG2755	lipolytic protein G-D-S-L family
GNX18_09720	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GNX18_09725	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GNX18_09735	COG0746	molybdenum cofactor guanylyltransferase activity
GNX18_09755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GNX18_09765	COG3707	response regulator
GNX18_09770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GNX18_09770	COG1116	anion transmembrane transporter activity
GNX18_09775	COG2223	nitrite transmembrane transporter activity
GNX18_09780	COG2223	nitrite transmembrane transporter activity
GNX18_09785	COG2815	serine threonine protein kinase
GNX18_09785	COG0515	serine threonine protein kinase
GNX18_09790	COG2146	nitrite reductase [NAD(P)H] activity
GNX18_09790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GNX18_09800	COG0243	molybdopterin cofactor binding
GNX18_09805	COG0303	'Molybdopterin
GNX18_09810	COG2329	Antibiotic biosynthesis monooxygenase
GNX18_09815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GNX18_09820	COG0412	Dienelactone hydrolase
GNX18_09825	COG1131	(ABC) transporter
GNX18_09830	COG0842	Transport permease protein
GNX18_09850	COG0584	glycerophosphoryl diester phosphodiesterase
GNX18_09860	COG0842	Transport permease protein
GNX18_09865	COG1131	(ABC) transporter
GNX18_09875	COG2197	response regulator
GNX18_09915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GNX18_09920	COG0505	Belongs to the CarA family
GNX18_09930	COG4067	protein conserved in archaea
GNX18_09930	COG0189	ligase activity
GNX18_09935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GNX18_09945	COG0484	heat shock protein binding
GNX18_09950	COG0443	Heat shock 70 kDa protein
GNX18_09955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GNX18_09960	COG0497	DNA recombination
GNX18_09980	COG2914	Belongs to the UPF0125 (RnfH) family
GNX18_09985	COG2867	negative regulation of translational initiation
GNX18_09990	COG0733	neurotransmitter:sodium symporter activity
GNX18_09995	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GNX18_10000	COG0733	neurotransmitter:sodium symporter activity
GNX18_10005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GNX18_10025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GNX18_10045	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GNX18_10055	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GNX18_10075	COG2076	Multidrug Resistance protein
GNX18_10090	COG1234	tRNA 3'-trailer cleavage
GNX18_10095	COG0557	exoribonuclease II activity
GNX18_10130	COG3047	cAMP biosynthetic process
GNX18_10150	COG4946	Tricorn protease homolog
GNX18_10150	COG1506	peptidase
GNX18_10150	COG0823	Involved in the tonB-independent uptake of proteins
GNX18_10165	COG1271	oxidase subunit
GNX18_10170	COG1294	oxidase, subunit
GNX18_10210	COG4145	pantothenate transmembrane transporter activity
GNX18_10215	COG0251	oxidation-reduction process
GNX18_10220	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GNX18_10235	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GNX18_10300	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GNX18_10325	COG2365	Tyrosine phosphatase family
GNX18_10355	COG0598	Magnesium transport protein CorA
GNX18_10365	COG3038	cytochrome b561
GNX18_10370	COG2353	YceI-like domain
GNX18_10375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GNX18_10385	COG0527	aspartate kinase activity
GNX18_10390	COG1917	Cupin 2, conserved barrel domain protein
GNX18_10415	COG0515	serine threonine protein kinase
GNX18_10415	COG2815	serine threonine protein kinase
GNX18_10420	COG0515	serine threonine protein kinase
GNX18_10420	COG2815	serine threonine protein kinase
GNX18_10465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GNX18_10475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GNX18_10480	COG0300	oxidoreductase activity
GNX18_10510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNX18_10550	COG3661	Belongs to the glycosyl hydrolase 67 family
GNX18_10555	COG4948	Mandelate Racemase Muconate Lactonizing
GNX18_10560	COG4447	cellulose binding
GNX18_10560	COG3291	Pkd domain containing protein
GNX18_10560	COG5520	Belongs to the glycosyl hydrolase 30 family
GNX18_10575	COG3693	PFAM glycoside hydrolase, family 10
GNX18_10585	COG1472	Belongs to the glycosyl hydrolase 3 family
GNX18_10595	COG0667	Aldo Keto reductase
GNX18_10600	COG3291	Pkd domain containing protein
GNX18_10615	COG3012	SEC-C Motif Domain Protein
GNX18_10615	COG3318	Belongs to the UPF0149 family
GNX18_10620	COG0366	Alpha amylase catalytic
GNX18_10655	COG1115	amino acid carrier protein
GNX18_10660	COG2186	Transcriptional regulator
GNX18_10690	COG1501	Belongs to the glycosyl hydrolase 31 family
GNX18_10695	COG3734	2-keto-3-deoxy-galactonokinase
GNX18_10710	COG1609	Transcriptional regulator
GNX18_10715	COG0673	inositol 2-dehydrogenase activity
GNX18_10725	COG2211	Major facilitator Superfamily
GNX18_10760	COG3345	alpha-galactosidase
GNX18_10785	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GNX18_10795	COG1609	Transcriptional regulator
GNX18_10820	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GNX18_10825	COG1472	Belongs to the glycosyl hydrolase 3 family
GNX18_10830	COG0477	Major facilitator Superfamily
GNX18_10880	COG1309	transcriptional regulator
GNX18_10890	COG0366	Alpha amylase catalytic
GNX18_10895	COG1501	Belongs to the glycosyl hydrolase 31 family
GNX18_10900	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GNX18_10925	COG0642	Histidine kinase
GNX18_10930	COG0745	RESPONSE REGULATOR receiver
GNX18_10960	COG0366	Alpha amylase catalytic
GNX18_10970	COG2133	pyrroloquinoline quinone binding
GNX18_10975	COG0366	Alpha amylase catalytic
GNX18_10980	COG0589	response to stress
GNX18_10990	COG3321	synthase
GNX18_10990	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_10990	COG0604	alcohol dehydrogenase
GNX18_11035	COG0837	glucose binding
GNX18_11055	COG1472	Belongs to the glycosyl hydrolase 3 family
GNX18_11100	COG3833	ABC-type maltose transport systems, permease component
GNX18_11110	COG3842	ATPase activity
GNX18_11135	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GNX18_11140	COG4206	TonB-dependent receptor
GNX18_11145	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GNX18_11150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNX18_11160	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GNX18_11200	COG2132	Multicopper oxidase
GNX18_11215	COG2217	Heavy metal translocating P-type atpase
GNX18_11220	COG0701	Predicted permease
GNX18_11270	COG0739	heme binding
GNX18_11275	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GNX18_11280	COG0316	Belongs to the HesB IscA family
GNX18_11295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GNX18_11310	COG0351	phosphomethylpyrimidine kinase
GNX18_11315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GNX18_11320	COG3135	benzoate transporter
GNX18_11345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GNX18_11350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GNX18_11355	COG5002	protein histidine kinase activity
GNX18_11355	COG5001	Diguanylate cyclase
GNX18_11385	COG0511	ligase activity, forming carbon-carbon bonds
GNX18_11395	COG2264	protein methyltransferase activity
GNX18_11410	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GNX18_11415	COG0138	bifunctional purine biosynthesis protein purh
GNX18_11420	COG0151	Belongs to the GarS family
GNX18_11425	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GNX18_11430	COG1765	OsmC-like protein
GNX18_11440	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GNX18_11455	COG0339	signal peptide processing
GNX18_11460	COG0523	cobalamin synthesis protein
GNX18_11480	COG0523	cobalamin synthesis protein
GNX18_11485	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_11505	COG0583	DNA-binding transcription factor activity
GNX18_11520	COG0134	indole-3-glycerol-phosphate synthase activity
GNX18_11525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GNX18_11530	COG0512	Glutamine amidotransferase of anthranilate synthase
GNX18_11540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GNX18_11545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GNX18_11550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GNX18_11555	COG3178	'Phosphotransferase
GNX18_11560	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GNX18_11565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GNX18_11570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GNX18_11575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GNX18_11580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GNX18_11585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GNX18_11590	COG2766	serine protein kinase
GNX18_11595	COG2718	Belongs to the UPF0229 family
GNX18_11600	COG2719	SpoVR family
GNX18_11605	COG2197	response regulator
GNX18_11615	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_11635	COG0745	RESPONSE REGULATOR receiver
GNX18_11640	COG2205	protein histidine kinase activity
GNX18_11650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GNX18_11655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GNX18_11660	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GNX18_11665	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GNX18_11670	COG1610	YqeY-like protein
GNX18_11675	COG0358	DNA primase activity
GNX18_11680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GNX18_11705	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GNX18_11710	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GNX18_11755	COG2814	Major facilitator Superfamily
GNX18_11765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GNX18_11775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GNX18_11780	COG1070	Carbohydrate kinase
GNX18_11785	COG2115	Belongs to the xylose isomerase family
GNX18_11790	COG1609	Transcriptional regulator
GNX18_11800	COG0129	dihydroxy-acid dehydratase activity
GNX18_11810	COG1741	Belongs to the pirin family
GNX18_11820	COG2755	lipolytic protein G-D-S-L family
GNX18_11845	COG3693	PFAM glycoside hydrolase, family 10
GNX18_11870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GNX18_11885	COG1904	glucuronate isomerase
GNX18_11890	COG0246	Mannitol dehydrogenase
GNX18_11895	COG3005	denitrification pathway
GNX18_11905	COG0243	molybdopterin cofactor binding
GNX18_11915	COG4459	periplasmic nitrate reductase
GNX18_11925	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_11930	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GNX18_11935	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GNX18_11940	COG4771	TonB-dependent receptor
GNX18_11950	COG2186	Transcriptional regulator
GNX18_11955	COG2721	sulfolactate sulfo-lyase activity
GNX18_11980	COG3264	Mechanosensitive ion channel
GNX18_11980	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GNX18_12010	COG2808	Putative FMN-binding domain
GNX18_12020	COG0110	maltose O-acetyltransferase activity
GNX18_12030	COG0346	lactoylglutathione lyase activity
GNX18_12060	COG3275	phosphorelay sensor kinase activity
GNX18_12075	COG1960	acyl-CoA dehydrogenase activity
GNX18_12080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GNX18_12085	COG3034	peptidoglycan biosynthetic process
GNX18_12090	COG0305	Participates in initiation and elongation during chromosome replication
GNX18_12095	COG0359	binds to the 23S rRNA
GNX18_12105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GNX18_12110	COG0360	Binds together with S18 to 16S ribosomal RNA
GNX18_12145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GNX18_12160	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GNX18_12180	COG2815	serine threonine protein kinase
GNX18_12180	COG0515	serine threonine protein kinase
GNX18_12190	COG3501	Rhs element vgr protein
GNX18_12305	COG2814	Major facilitator Superfamily
GNX18_12315	COG2951	lytic endotransglycosylase activity
GNX18_12320	COG1272	protein, Hemolysin III
GNX18_12345	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GNX18_12350	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GNX18_12355	COG0330	HflC and HflK could
GNX18_12360	COG0330	HflC and HflK could
GNX18_12365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GNX18_12370	COG1923	regulation of RNA biosynthetic process
GNX18_12380	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GNX18_12385	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNX18_12390	COG0802	atpase or kinase
GNX18_12395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GNX18_12395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GNX18_12410	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GNX18_12415	COG1162	GTPase activity
GNX18_12425	COG0688	phosphatidylethanolamine metabolic process
GNX18_12430	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GNX18_12430	COG2199	diguanylate cyclase activity
GNX18_12435	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GNX18_12440	COG1757	Na H antiporter
GNX18_12445	COG0493	'glutamate synthase
GNX18_12450	COG0070	glutamate synthase
GNX18_12450	COG0067	glutamate synthase
GNX18_12450	COG0069	glutamate synthase activity
GNX18_12455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GNX18_12460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GNX18_12500	COG0784	Response regulator, receiver
GNX18_12500	COG2198	Histidine kinase
GNX18_12500	COG2198	Histidine kinase
GNX18_12500	COG0643	Histidine kinase
GNX18_12500	COG0784	Response regulator, receiver
GNX18_12500	COG0643	Histidine kinase
GNX18_12505	COG0840	transmembrane signaling receptor activity
GNX18_12525	COG0189	ligase activity
GNX18_12535	COG1678	Uncharacterized ACR, COG1678
GNX18_12540	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GNX18_12685	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GNX18_12690	COG0724	RNA recognition motif
GNX18_12705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GNX18_12720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GNX18_12720	COG2813	Specifically methylates the guanine in position
GNX18_12725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GNX18_12780	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_12795	COG2972	Histidine kinase
GNX18_12795	COG0745	RESPONSE REGULATOR receiver
GNX18_12800	COG0165	Argininosuccinate lyase
GNX18_12810	COG1965	Belongs to the frataxin family
GNX18_12825	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GNX18_12840	COG0347	Belongs to the P(II) protein family
GNX18_12845	COG0004	ammonium transporteR
GNX18_12850	COG0347	Belongs to the P(II) protein family
GNX18_12865	COG0606	chelatase, subunit chli
GNX18_12885	COG1671	Belongs to the UPF0178 family
GNX18_12895	COG0659	secondary active sulfate transmembrane transporter activity
GNX18_12905	COG0210	DNA helicase
GNX18_12920	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GNX18_12935	COG0656	L-ascorbic acid biosynthetic process
GNX18_12940	COG2814	Major facilitator Superfamily
GNX18_12945	COG0583	DNA-binding transcription factor activity
GNX18_12950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GNX18_12960	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GNX18_12965	COG0315	cyclic pyranopterin monophosphate synthase activity
GNX18_12970	COG0521	Mo-molybdopterin cofactor biosynthetic process
GNX18_12975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GNX18_12990	COG2223	nitrite transmembrane transporter activity
GNX18_12995	COG2815	serine threonine protein kinase
GNX18_12995	COG0515	serine threonine protein kinase
GNX18_13000	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GNX18_13000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GNX18_13020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GNX18_13025	COG0826	peptidase U32
GNX18_13030	COG0826	peptidase U32
GNX18_13035	COG3154	lipid carrier protein
GNX18_13040	COG2181	nitrate reductase activity
GNX18_13045	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GNX18_13050	COG1140	nitrate reductase beta subunit
GNX18_13055	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GNX18_13060	COG3850	Histidine kinase
GNX18_13075	COG1959	2 iron, 2 sulfur cluster binding
GNX18_13100	COG2223	nitrite transmembrane transporter activity
GNX18_13105	COG2197	response regulator
GNX18_13115	COG4771	TonB-dependent receptor
GNX18_13135	COG0492	ferredoxin-NADP+ reductase activity
GNX18_13140	COG1959	2 iron, 2 sulfur cluster binding
GNX18_13145	COG1741	Belongs to the pirin family
GNX18_13195	COG0346	lactoylglutathione lyase activity
GNX18_13205	COG2268	Band 7 protein
GNX18_13260	COG1696	Membrane protein involved in D-alanine export
GNX18_13275	COG0438	transferase activity, transferring glycosyl groups
GNX18_13280	COG4447	cellulose binding
GNX18_13280	COG5520	Belongs to the glycosyl hydrolase 30 family
GNX18_13280	COG3291	Pkd domain containing protein
GNX18_13340	COG0583	DNA-binding transcription factor activity
GNX18_13350	COG2186	Transcriptional regulator
GNX18_13370	COG1917	Cupin 2, conserved barrel domain protein
GNX18_13375	COG2271	Major facilitator Superfamily
GNX18_13380	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_13385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GNX18_13400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GNX18_13400	COG0456	acetyltransferase
GNX18_13445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GNX18_13475	COG1121	(ABC) transporter
GNX18_13480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GNX18_13495	COG0109	protoheme IX farnesyltransferase activity
GNX18_13500	COG1612	heme a metabolic process
GNX18_13525	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GNX18_13530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GNX18_13535	COG1565	acr, cog1565
GNX18_13535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GNX18_13540	COG0534	Mate efflux family protein
GNX18_13560	COG0339	signal peptide processing
GNX18_13565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GNX18_13585	COG2235	arginine
GNX18_13600	COG0583	DNA-binding transcription factor activity
GNX18_13610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GNX18_13615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GNX18_13625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GNX18_13635	COG0408	coproporphyrinogen oxidase activity
GNX18_13640	COG0009	L-threonylcarbamoyladenylate synthase
GNX18_13650	COG0758	DNA mediated transformation
GNX18_13655	COG1652	LysM domain
GNX18_13660	COG0242	peptide deformylase activity
GNX18_13665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GNX18_13675	COG0569	domain protein
GNX18_13680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GNX18_13685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GNX18_13700	COG1136	(ABC) transporter
GNX18_13705	COG0577	efflux transmembrane transporter activity
GNX18_13710	COG0577	efflux transmembrane transporter activity
GNX18_13740	COG1560	Kdo2-lipid A biosynthetic process
GNX18_13745	COG0752	glycyl-tRNA synthetase alpha subunit
GNX18_13750	COG0751	glycine-tRNA ligase activity
GNX18_13760	COG1404	Belongs to the peptidase S8 family
GNX18_13765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GNX18_13770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GNX18_13790	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GNX18_13795	COG0592	DNA-directed DNA polymerase activity
GNX18_13800	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GNX18_13805	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GNX18_13810	COG0594	ribonuclease P activity
GNX18_13815	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GNX18_13820	COG0706	membrane insertase activity
GNX18_13825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GNX18_13830	COG2807	transmembrane transport
GNX18_13835	COG0445	tRNA wobble uridine modification
GNX18_13840	COG0357	Ribosomal RNA small subunit methyltransferase G
GNX18_13845	COG1192	Involved in chromosome partitioning
GNX18_13850	COG1475	DNA binding
GNX18_13860	COG0356	it plays a direct role in the translocation of protons across the membrane
GNX18_13870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GNX18_13880	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GNX18_13885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GNX18_13890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GNX18_13895	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GNX18_13900	COG1752	Esterase of the alpha-beta hydrolase superfamily
GNX18_13910	COG0402	S-adenosylhomocysteine deaminase activity
GNX18_13920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GNX18_13940	COG1349	DNA-binding transcription factor activity
GNX18_13945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GNX18_13975	COG1629	transport
GNX18_13975	COG4774	siderophore transport
GNX18_13980	COG3040	lipid binding
GNX18_13985	COG1271	oxidase subunit
GNX18_13990	COG1294	oxidase, subunit
GNX18_14030	COG0457	Tetratricopeptide repeat
GNX18_14045	COG1741	Belongs to the pirin family
GNX18_14050	COG0583	DNA-binding transcription factor activity
GNX18_14055	COG0673	inositol 2-dehydrogenase activity
GNX18_14060	COG2259	Doxx family
GNX18_14065	COG0435	Glutathione S-transferase
GNX18_14070	COG0625	glutathione transferase activity
GNX18_14075	COG2814	Major facilitator Superfamily
GNX18_14080	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GNX18_14090	COG0210	DNA helicase
GNX18_14095	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GNX18_14105	COG0653	protein targeting
GNX18_14110	COG0459	protein refolding
GNX18_14115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GNX18_14125	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GNX18_14130	COG1607	acyl-coa hydrolase
GNX18_14135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GNX18_14150	COG0573	inorganic phosphate transmembrane transporter activity
GNX18_14160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GNX18_14165	COG0704	Plays a role in the regulation of phosphate uptake
GNX18_14190	COG3022	response to hydroperoxide
GNX18_14220	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GNX18_14225	COG3161	chorismate lyase activity
GNX18_14230	COG1301	dicarboxylic acid transport
GNX18_14245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GNX18_14250	COG0583	DNA-binding transcription factor activity
GNX18_14255	COG2261	transglycosylase associated protein
GNX18_14270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GNX18_14275	COG1758	RNA polymerase activity
GNX18_14280	COG0194	GDP metabolic process
GNX18_14290	COG1064	alcohol dehydrogenase
GNX18_14295	COG1404	Belongs to the peptidase S8 family
GNX18_14310	COG1561	YicC-like family, N-terminal region
GNX18_14315	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GNX18_14325	COG0708	Exodeoxyribonuclease III
GNX18_14330	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GNX18_14340	COG1309	transcriptional regulator
GNX18_14345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GNX18_14350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GNX18_14355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GNX18_14360	COG2003	Belongs to the UPF0758 family
GNX18_14365	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GNX18_14370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GNX18_14375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GNX18_14380	COG0405	Gamma-glutamyltransferase
GNX18_14385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GNX18_14390	COG0742	ribosomal rna small subunit methyltransferase
GNX18_14395	COG0552	protein localization to endoplasmic reticulum
GNX18_14400	COG2884	Cell division ATP-binding protein ftsE
GNX18_14405	COG2177	Part of the ABC transporter FtsEX involved in
GNX18_14415	COG2363	Small membrane protein
GNX18_14420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GNX18_14435	COG0488	(ABC) transporter
GNX18_14460	COG1346	cytolysis
GNX18_14470	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GNX18_14480	COG2918	glutathione biosynthetic process
GNX18_14490	COG0281	malic enzyme
GNX18_14505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GNX18_14520	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GNX18_14525	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GNX18_14555	COG2226	methyltransferase
GNX18_14565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GNX18_14570	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GNX18_14575	COG0140	phosphoribosyl-ATP diphosphatase activity
GNX18_14580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GNX18_14585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GNX18_14605	COG1490	D-aminoacyl-tRNA deacylase activity
GNX18_14610	COG1505	serine-type exopeptidase activity
GNX18_14615	COG0668	transmembrane transport
GNX18_14635	COG3706	GGDEF domain
GNX18_14640	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GNX18_14665	COG1404	Belongs to the peptidase S8 family
GNX18_14680	COG2824	Alkylphosphonate utilization operon protein PhnA
GNX18_14685	COG0659	secondary active sulfate transmembrane transporter activity
GNX18_14705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GNX18_14710	COG0301	tRNA thio-modification
GNX18_14710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GNX18_14715	COG0174	glutamine synthetase
GNX18_14725	COG3852	Histidine kinase
GNX18_14730	COG2204	response regulator
GNX18_14740	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GNX18_14745	COG0628	permease
GNX18_14760	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GNX18_14765	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GNX18_14775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GNX18_14780	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GNX18_14785	COG1011	Hydrolase
GNX18_14825	COG0714	Associated with various cellular activities
GNX18_14980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNX18_14995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GNX18_15000	COG4771	TonB-dependent receptor
GNX18_15030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GNX18_15040	COG1401	restriction endodeoxyribonuclease activity
GNX18_15055	COG3645	SOS response
GNX18_15070	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GNX18_15130	COG0131	Imidazoleglycerol-phosphate dehydratase
GNX18_15140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GNX18_15145	COG0107	imidazoleglycerol-phosphate synthase activity
GNX18_15155	COG0793	Belongs to the peptidase S41A family
GNX18_15170	COG1063	alcohol dehydrogenase
GNX18_15175	COG1846	Transcriptional regulator
GNX18_15180	COG4942	peptidase
GNX18_15185	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GNX18_15190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GNX18_15200	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GNX18_15210	COG0300	oxidoreductase activity
GNX18_15235	COG4771	TonB-dependent receptor
GNX18_15240	COG2205	protein histidine kinase activity
GNX18_15245	COG2807	transmembrane transport
GNX18_15260	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_15280	COG0560	Phosphoserine phosphatase
GNX18_15295	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GNX18_15300	COG1509	lysine 2,3-aminomutase activity
GNX18_15305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GNX18_15310	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GNX18_15325	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GNX18_15350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GNX18_15355	COG0156	8-amino-7-oxononanoate synthase activity
GNX18_15360	COG2226	methyltransferase
GNX18_15360	COG1073	alpha beta
GNX18_15365	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GNX18_15370	COG3214	Protein conserved in bacteria
GNX18_15380	COG0010	Belongs to the arginase family
GNX18_15395	COG1166	arginine decarboxylase activity
GNX18_15405	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GNX18_15410	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GNX18_15415	COG0427	acetyl-CoA hydrolase
GNX18_15425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GNX18_15480	COG4770	biotin carboxylase activity
GNX18_15485	COG1024	Enoyl-CoA hydratase
GNX18_15490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GNX18_15495	COG1960	acyl-CoA dehydrogenase activity
GNX18_15500	COG0789	Transcriptional regulator
GNX18_15535	COG0747	negative chemotaxis
GNX18_15540	COG0601	transmembrane transport
GNX18_15550	COG0444	Belongs to the ABC transporter superfamily
GNX18_15555	COG4608	Belongs to the ABC transporter superfamily
GNX18_15575	COG2986	histidine ammonia-lyase
GNX18_15580	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GNX18_15590	COG1228	amidohydrolase
GNX18_15595	COG0010	Belongs to the arginase family
GNX18_15615	COG2977	Belongs to the P-Pant transferase superfamily
GNX18_15635	COG1454	alcohol dehydrogenase
GNX18_15640	COG0824	Thioesterase
GNX18_15665	COG1280	lysine exporter protein (LysE YggA)
GNX18_15680	COG0564	pseudouridine synthase activity
GNX18_15690	COG1764	response to oxidative stress
GNX18_15695	COG1846	Transcriptional regulator
GNX18_15700	COG2183	response to ionizing radiation
GNX18_15715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GNX18_15725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GNX18_15735	COG1297	OPT oligopeptide transporter protein
GNX18_15745	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GNX18_15750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GNX18_15755	COG2264	protein methyltransferase activity
GNX18_15760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GNX18_15765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GNX18_15795	COG4773	Receptor
GNX18_15835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GNX18_15840	COG0730	response to heat
GNX18_15870	COG0109	protoheme IX farnesyltransferase activity
GNX18_15890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GNX18_15905	COG0612	Peptidase, M16
GNX18_15920	COG0126	phosphoglycerate kinase activity
GNX18_15935	COG2962	Rard protein
GNX18_15940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GNX18_15945	COG0179	Fumarylacetoacetate (FAA) hydrolase
GNX18_15975	COG1012	belongs to the aldehyde dehydrogenase family
GNX18_15995	COG0861	Integral membrane protein TerC family
GNX18_16085	COG0076	glutamate decarboxylase activity
GNX18_16100	COG0488	(ABC) transporter
GNX18_16110	COG1278	Cold shock
GNX18_16115	COG1132	(ABC) transporter
GNX18_16130	COG0488	(ABC) transporter
GNX18_16145	COG0625	glutathione transferase activity
GNX18_16160	COG0513	Belongs to the DEAD box helicase family
GNX18_16170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GNX18_16240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GNX18_16290	COG4628	conserved protein (DUF2132)
GNX18_16300	COG1960	acyl-CoA dehydrogenase activity
GNX18_16305	COG2885	chlorophyll binding
GNX18_16330	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GNX18_16335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GNX18_16340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GNX18_16365	COG0006	proline dipeptidase activity
GNX18_16370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GNX18_16375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GNX18_16380	COG0705	Rhomboid family
GNX18_16385	COG1253	flavin adenine dinucleotide binding
GNX18_16420	COG3273	potassium ion transport
GNX18_16420	COG0471	metal ion transport
GNX18_16425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GNX18_16430	COG0509	glycine decarboxylation via glycine cleavage system
GNX18_16435	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GNX18_16440	COG0494	nUDIX hydrolase
GNX18_16455	COG3108	Peptidase M15
GNX18_16460	COG2989	Protein conserved in bacteria
GNX18_16465	COG2989	Protein conserved in bacteria
GNX18_16480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GNX18_16485	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GNX18_16500	COG0811	peptide transport
GNX18_16510	COG0848	biopolymer transport protein
GNX18_16515	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GNX18_16525	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GNX18_16530	COG0129	dihydroxy-acid dehydratase activity
GNX18_16535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GNX18_16535	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GNX18_16545	COG0697	spore germination
GNX18_16560	COG0306	phosphate transporter
GNX18_16565	COG1392	Phosphate transport regulator
GNX18_16570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GNX18_16595	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GNX18_16635	COG0438	transferase activity, transferring glycosyl groups
GNX18_16645	COG0438	transferase activity, transferring glycosyl groups
GNX18_16650	COG1215	transferase activity, transferring glycosyl groups
GNX18_16655	COG1519	Transferase
GNX18_16665	COG0463	Glycosyl transferase, family 2
GNX18_16685	COG1538	Outer membrane efflux protein
GNX18_16690	COG2995	paraquat-inducible protein a
GNX18_16695	COG2995	paraquat-inducible protein a
GNX18_16700	COG3008	intermembrane lipid transfer
GNX18_16715	COG0494	nUDIX hydrolase
GNX18_16720	COG3151	Protein conserved in bacteria
GNX18_16725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GNX18_16735	COG3150	esterase
GNX18_16770	COG1472	Belongs to the glycosyl hydrolase 3 family
GNX18_16775	COG1472	Belongs to the glycosyl hydrolase 3 family
GNX18_16795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GNX18_16810	COG3408	Glycogen debranching enzyme
GNX18_16815	COG2211	Major facilitator Superfamily
GNX18_16820	COG0129	dihydroxy-acid dehydratase activity
GNX18_16825	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_16845	COG3940	Belongs to the glycosyl hydrolase 43 family
GNX18_16880	COG1960	acyl-CoA dehydrogenase activity
GNX18_16885	COG0800	Aldolase
GNX18_16890	COG1304	FMN binding
GNX18_16900	COG1028	Short-chain dehydrogenase reductase Sdr
GNX18_16900	COG3347	Dehydrogenase
GNX18_16905	COG4952	isomerase
GNX18_16960	COG0385	Bile acid
GNX18_16965	COG0513	Belongs to the DEAD box helicase family
GNX18_16970	COG1473	amidohydrolase
GNX18_16980	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GNX18_16985	COG3047	cAMP biosynthetic process
GNX18_16995	COG0829	nickel cation binding
GNX18_17000	COG0831	urea catabolic process
GNX18_17005	COG0832	Belongs to the urease beta subunit family
GNX18_17010	COG0804	urea catabolic process
GNX18_17015	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GNX18_17020	COG0830	nickel cation binding
GNX18_17025	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GNX18_17040	COG2070	2-Nitropropane dioxygenase
GNX18_17050	COG0745	RESPONSE REGULATOR receiver
GNX18_17055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GNX18_17055	COG2205	protein histidine kinase activity
GNX18_17100	COG3940	Belongs to the glycosyl hydrolase 43 family
GNX18_17105	COG2211	Major facilitator Superfamily
GNX18_17110	COG2186	Transcriptional regulator
GNX18_17135	COG3507	Belongs to the glycosyl hydrolase 43 family
GNX18_17140	COG2207	Transcriptional regulator
GNX18_17140	COG4753	response regulator
GNX18_17150	COG3693	PFAM glycoside hydrolase, family 10
GNX18_17160	COG2755	lipolytic protein G-D-S-L family
GNX18_17160	COG0657	acetylesterase activity
GNX18_17165	COG3507	Belongs to the glycosyl hydrolase 43 family
GNX18_17185	COG2017	converts alpha-aldose to the beta-anomer
GNX18_17190	COG1879	ABC-type sugar transport system periplasmic component
GNX18_17195	COG1129	ABC transporter
GNX18_17200	COG1172	Belongs to the binding-protein-dependent transport system permease family
GNX18_17205	COG1172	Belongs to the binding-protein-dependent transport system permease family
GNX18_17215	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GNX18_17225	COG3507	Belongs to the glycosyl hydrolase 43 family
GNX18_17230	COG3940	Belongs to the glycosyl hydrolase 43 family
GNX18_17240	COG1082	Xylose isomerase domain protein TIM barrel
GNX18_17250	COG3534	alpha-L-arabinofuranosidase
GNX18_17255	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GNX18_17265	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GNX18_17270	COG2205	protein histidine kinase activity
GNX18_17270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GNX18_17285	COG3507	Belongs to the glycosyl hydrolase 43 family
GNX18_17295	COG0488	(ABC) transporter
GNX18_17300	COG1024	Enoyl-CoA hydratase
GNX18_17315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GNX18_17330	COG3721	Heme iron utilization protein
GNX18_17345	COG0811	peptide transport
GNX18_17350	COG0848	biopolymer transport protein
GNX18_17360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNX18_17365	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GNX18_17370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GNX18_17375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GNX18_17380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GNX18_17380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GNX18_17395	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GNX18_17400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GNX18_17410	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GNX18_17420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GNX18_17425	COG1162	GTPase activity
GNX18_17435	COG2205	protein histidine kinase activity
GNX18_17440	COG4206	TonB-dependent receptor
GNX18_17455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GNX18_17460	COG0142	geranyltranstransferase activity
GNX18_17480	COG4191	Histidine kinase
GNX18_17500	COG1181	Belongs to the D-alanine--D-alanine ligase family
GNX18_17510	COG0471	metal ion transport
GNX18_17510	COG3273	potassium ion transport
GNX18_17530	COG1252	NADH dehydrogenase
GNX18_17540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GNX18_17630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GNX18_17640	COG0657	acetylesterase activity
GNX18_17640	COG2755	lipolytic protein G-D-S-L family
GNX18_17665	COG0667	Aldo Keto reductase
GNX18_17670	COG0583	DNA-binding transcription factor activity
GNX18_17675	COG0390	transport system, permease component
GNX18_17680	COG1116	anion transmembrane transporter activity
GNX18_17695	COG0583	DNA-binding transcription factor activity
GNX18_17710	COG4447	cellulose binding
GNX18_17710	COG5520	Belongs to the glycosyl hydrolase 30 family
GNX18_17710	COG3291	Pkd domain containing protein
GNX18_17730	COG1566	PFAM secretion protein HlyD family protein
GNX18_17735	COG2814	Major facilitator Superfamily
GNX18_17750	COG3507	Belongs to the glycosyl hydrolase 43 family
GNX18_17755	COG2211	Major facilitator Superfamily
GNX18_17765	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GNX18_17770	COG0248	Ppx GppA phosphatase
GNX18_17775	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GNX18_17790	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GNX18_17795	COG2095	MarC family integral membrane protein
GNX18_17800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GNX18_17800	COG4651	solute:proton antiporter activity
GNX18_17805	COG0477	Major facilitator Superfamily
GNX18_17815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GNX18_17840	COG4989	oxidoreductase activity
GNX18_17850	COG0596	Alpha beta hydrolase
GNX18_17855	COG1131	(ABC) transporter
GNX18_17860	COG1668	transmembrane transport
GNX18_17865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GNX18_17875	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GNX18_17905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GNX18_17925	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GNX18_17930	COG0081	regulation of translation
GNX18_17935	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GNX18_17940	COG0222	ribosome binding
GNX18_17945	COG0085	RNA polymerase activity
GNX18_17950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GNX18_17955	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GNX18_17960	COG0049	tRNA binding
GNX18_17965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GNX18_17970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GNX18_17980	COG0051	transcription antitermination factor activity, RNA binding
GNX18_17985	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GNX18_17990	COG0088	Forms part of the polypeptide exit tunnel
GNX18_17995	COG0089	rRNA binding
GNX18_18000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GNX18_18005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GNX18_18010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GNX18_18015	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GNX18_18020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GNX18_18025	COG0255	Belongs to the universal ribosomal protein uL29 family
GNX18_18030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GNX18_18035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GNX18_18040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GNX18_18045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GNX18_18050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GNX18_18055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GNX18_18060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GNX18_18065	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GNX18_18070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GNX18_18075	COG1841	ribosomal large subunit assembly
GNX18_18080	COG0200	Binds to the 23S rRNA
GNX18_18090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GNX18_18095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GNX18_18100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GNX18_18105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GNX18_18110	COG0202	RNA polymerase activity
GNX18_18115	COG0203	ribosomal protein L17
GNX18_18120	COG3139	Protein of unknown function (DUF1315)
GNX18_18125	COG1984	allophanate hydrolase subunit 2
GNX18_18130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GNX18_18135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GNX18_18150	COG2814	Major facilitator Superfamily
GNX18_18170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GNX18_18185	COG0142	geranyltranstransferase activity
GNX18_18190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GNX18_18195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GNX18_18200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GNX18_18205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GNX18_18210	COG0268	Binds directly to 16S ribosomal RNA
GNX18_18215	COG5002	protein histidine kinase activity
GNX18_18220	COG0745	RESPONSE REGULATOR receiver
GNX18_18225	COG2885	chlorophyll binding
GNX18_18235	COG0728	peptidoglycan biosynthetic process
GNX18_18240	COG0196	riboflavin kinase activity
GNX18_18245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GNX18_18250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GNX18_18255	COG1047	Peptidyl-prolyl cis-trans
GNX18_18260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GNX18_18310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GNX18_18310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GNX18_18335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GNX18_18340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GNX18_18350	COG0028	Belongs to the TPP enzyme family
GNX18_18360	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GNX18_18365	COG1183	phosphatidylcholine synthase activity
GNX18_18405	COG2433	Pfam Transposase IS66
GNX18_18410	COG0386	Belongs to the glutathione peroxidase family
GNX18_18415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GNX18_18425	COG0456	acetyltransferase
GNX18_18430	COG0534	Mate efflux family protein
GNX18_18445	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GNX18_18470	COG0477	Major facilitator Superfamily
GNX18_18475	COG3590	peptidase
GNX18_18490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GNX18_18500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GNX18_18520	COG1803	Methylglyoxal synthase
GNX18_18525	COG0848	biopolymer transport protein
GNX18_18530	COG3483	tryptophan 2,3-dioxygenase activity
GNX18_18535	COG1024	Enoyl-CoA hydratase
GNX18_18540	COG3706	GGDEF domain
GNX18_18585	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GNX18_18620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GNX18_18645	COG4660	Part of a membrane complex involved in electron transport
GNX18_18650	COG4659	FMN binding
GNX18_18655	COG4658	electron transport chain
GNX18_18665	COG2878	Part of a membrane complex involved in electron transport
GNX18_18670	COG4657	Part of a membrane complex involved in electron transport
GNX18_18700	COG0454	-acetyltransferase
GNX18_18710	COG0583	DNA-binding transcription factor activity
GNX18_18715	COG0625	glutathione transferase activity
GNX18_18725	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
GNX18_18730	COG0515	serine threonine protein kinase
GNX18_18730	COG2815	serine threonine protein kinase
GNX18_18735	COG2116	formate transmembrane transporter activity
GNX18_18765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GNX18_18770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GNX18_18770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GNX18_18775	COG0489	protein tyrosine kinase activity
GNX18_18820	COG0247	lactate metabolic process
GNX18_18820	COG0277	FAD linked oxidase domain protein
GNX18_18830	COG0415	Belongs to the DNA photolyase family
GNX18_18850	COG1522	sequence-specific DNA binding
GNX18_18870	COG0741	lytic transglycosylase activity
GNX18_18875	COG0442	prolyl-tRNA aminoacylation
GNX18_18880	COG0776	regulation of translation
GNX18_18890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GNX18_18900	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GNX18_18905	COG0632	four-way junction helicase activity
GNX18_18910	COG2255	four-way junction helicase activity
GNX18_18915	COG0824	Thioesterase
GNX18_18935	COG0823	Involved in the tonB-independent uptake of proteins
GNX18_18940	COG2885	chlorophyll binding
GNX18_18950	COG0602	queuosine metabolic process
GNX18_18955	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GNX18_18970	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GNX18_18980	COG0425	Belongs to the sulfur carrier protein TusA family
GNX18_18990	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GNX18_19010	COG0508	dehydrogenase complex catalyzes the overall conversion of
GNX18_19070	COG2197	response regulator
GNX18_19085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GNX18_19090	COG4977	sequence-specific DNA binding
GNX18_19095	COG3852	Histidine kinase
GNX18_19100	COG2204	response regulator
GNX18_19105	COG0577	efflux transmembrane transporter activity
GNX18_19115	COG1136	(ABC) transporter
GNX18_19125	COG0659	secondary active sulfate transmembrane transporter activity
GNX18_19130	COG0589	response to stress
GNX18_19140	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GNX18_19145	COG0667	Aldo Keto reductase
GNX18_19155	COG1560	Kdo2-lipid A biosynthetic process
GNX18_19160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GNX18_19170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GNX18_19190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GNX18_19195	COG1428	Deoxynucleoside kinase
GNX18_19215	COG3852	Histidine kinase
GNX18_19225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GNX18_19230	COG1489	DNA binding
GNX18_19245	COG0501	Belongs to the peptidase M48B family
GNX18_19295	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GNX18_19320	COG4771	TonB-dependent receptor
GNX18_19340	COG3201	nicotinamide mononucleotide transporter
GNX18_19350	COG4771	TonB-dependent receptor