locus-tag class description FOE78_00015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOE78_00020 ENOG4105BZU Histidine kinase FOE78_00060 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FOE78_00065 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FOE78_00075 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_00080 ENOG4105C2M dna polymerase I FOE78_00095 ENOG4105EDW glycosyl transferase, family 39 FOE78_00110 ENOG4105E90 ABC transporter FOE78_00115 ENOG4105E90 ABC transporter FOE78_00125 ENOG4106UW1 Major Facilitator superfamily FOE78_00140 ENOG4105DF6 Fe-S oxidoreductase FOE78_00160 ENOG4105DHP deoxycytidine triphosphate deaminase FOE78_00200 ENOG4105BZU Histidine kinase FOE78_00205 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_00225 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase FOE78_00235 ENOG4107QRT dEAD DEAH box helicase FOE78_00270 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOE78_00275 ENOG4105CAN Short-chain dehydrogenase reductase Sdr FOE78_00280 ENOG4105C1G acyl-Coa dehydrogenase FOE78_00285 ENOG4105CEY Amp-dependent synthetase and ligase FOE78_00310 ENOG4106F60 Histidine kinase FOE78_00335 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FOE78_00350 ENOG4105CKV Membrane FOE78_00355 ENOG4105DFK Polyphosphate glucokinase FOE78_00360 ENOG4105C75 arginyL-tRNA synthetase FOE78_00370 ENOG4105CHP RNA polymerase FOE78_00385 ENOG4107QZF nitrite reductase NADPH large subunit FOE78_00390 ENOG4107QND Nitrite extrusion protein FOE78_00395 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FOE78_00410 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) FOE78_00425 ENOG4107QP8 phosphohexose isomerase FOE78_00445 ENOG4108VX5 3-methyladenine DNA glycosylase FOE78_00460 ENOG4107TYG Oxidoreductase domain-containing protein FOE78_00465 ENOG4107RBI VanW family FOE78_00470 ENOG4105J5G Transferase hexapeptide repeat containing protein FOE78_00525 ENOG4108SHN Glycosyl transferase, family 2 FOE78_00575 ENOG4105EV8 ectoine hydroxylase FOE78_00590 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FOE78_00605 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOE78_00610 ENOG4105CSU acyl-Coa dehydrogenase FOE78_00625 ENOG4105C57 major facilitator superfamily FOE78_00630 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 FOE78_00635 ENOG4105CPP Dehydrogenase, E1 component FOE78_00660 ENOG4105D29 Helix-turn-helix type 11 domain protein FOE78_00680 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOE78_00690 ENOG4105ETE Transcriptional regulator (LacI family FOE78_00695 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FOE78_00700 ENOG4105D56 permease protein FOE78_00710 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOE78_00750 ENOG4105C3U ABC transporter FOE78_00755 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOE78_00760 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOE78_00765 ENOG4107QSI ABC, transporter FOE78_00775 ENOG4105BZ1 (ABC) transporter FOE78_00780 ENOG4105BZ1 (ABC) transporter FOE78_00795 ENOG4105C5X domain protein FOE78_00805 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOE78_00810 ENOG4105CPC Aldo Keto reductase FOE78_00815 ENOG41082T9 Membrane FOE78_00820 ENOG4105KJF protein tyrosine phosphatase FOE78_00840 ENOG4105EYF MMPL domain protein FOE78_00850 ENOG4105ETX regulatoR FOE78_00855 ENOG41062D9 Histidine kinase FOE78_00870 ENOG4105C1J atp-dependent rna helicase FOE78_00875 ENOG4107XFJ UPF0246 protein FOE78_00905 ENOG4105JXB ankyrin repeat-containing protein FOE78_00910 ENOG4105CRK lysyL-tRNA synthetase FOE78_00920 ENOG4107VXZ Hydrolase FOE78_00960 ENOG4105C7B Threonine dehydratase FOE78_00990 ENOG4105CUV Homoserine Kinase FOE78_01005 ENOG4105C4M (Ubiquinol oxidase) subunit I FOE78_01010 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOE78_01015 ENOG4108JJ9 ABC, transporter FOE78_01020 ENOG4108JJ8 (ABC) transporter FOE78_01035 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOE78_01040 ENOG4105CPQ Dehydrogenase FOE78_01050 ENOG4108E1C hydrolase FOE78_01055 ENOG4108URH decarboxylase FOE78_01080 ENOG4108Z5V transcriptional regulator, merr family FOE78_01100 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOE78_01110 ENOG4105DKW ABC transporter FOE78_01115 ENOG4105ETE Transcriptional regulator (LacI family FOE78_01120 ENOG4105CNT hydrolase family 2 FOE78_01155 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FOE78_01165 ENOG4105CDU Replicative dna helicase FOE78_01170 ENOG4105VPX protein, conserved in bacteria FOE78_01180 ENOG4105NAE bifunctional deaminase-reductase domain protein FOE78_01240 ENOG4105EY8 ABC transporter FOE78_01285 ENOG4105CIR epoxide hydrolase FOE78_01340 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase FOE78_01345 ENOG4105C3M thioredoxin reductase FOE78_01350 ENOG4105K63 Thioredoxin FOE78_01360 ENOG4105CXK mandelate racemase muconate lactonizing FOE78_01365 ENOG4105DEI Mannitol dehydrogenase FOE78_01390 ENOG4105VCH membrane FOE78_01400 ENOG4107QJE Chromosome Partitioning Protein FOE78_01405 ENOG4105F5W AtP-binding protein FOE78_01415 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FOE78_01425 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOE78_01435 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FOE78_01440 ENOG41084CH 50S ribosomal protein l34 FOE78_01445 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FOE78_01450 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FOE78_01455 ENOG4105E90 ABC transporter FOE78_01460 ENOG4108IJ8 ABC transporter FOE78_01465 ENOG4105E90 ABC transporter FOE78_01470 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system FOE78_01475 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOE78_01480 ENOG4108J5G 6-phosphogluconate dehydrogenase FOE78_01485 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOE78_01490 ENOG4105K7N UPF0232 protein FOE78_01525 ENOG4105CBG Sulfatase FOE78_01530 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOE78_01535 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOE78_01545 ENOG4105D5G Transposase FOE78_01580 ENOG4105FQP Beta-lactamase FOE78_01595 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOE78_01600 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_01605 ENOG4108ZGX Histidine kinase FOE78_01610 ENOG4105DJ2 Major Facilitator Superfamily FOE78_01630 ENOG4105DU0 nucleoside hydrolase FOE78_01745 ENOG4105E4C Lytic transglycosylase catalytic FOE78_01770 ENOG4105E18 UPF0276 protein FOE78_01780 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FOE78_01825 ENOG4105VTR Integrase FOE78_01845 ENOG4105BZ4 penicillin-binding protein FOE78_01875 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) FOE78_01900 ENOG4105CHP RNA polymerase FOE78_01920 ENOG4108594 Permease of the drug metabolite transporter FOE78_01925 ENOG4105C5Q Transcriptional regulator FOE78_01960 ENOG4105CQB FAD linked oxidase domain protein FOE78_01975 ENOG4108IXY short-chain dehydrogenase reductase FOE78_01980 ENOG4105CZN Potassium uptake protein FOE78_01985 ENOG4107ZYR domain protein FOE78_02005 ENOG4105D0M Protease HtpX homolog FOE78_02035 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) FOE78_02040 ENOG4107YH6 single-stranded DNA-binding protein FOE78_02045 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FOE78_02050 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FOE78_02055 ENOG4105CBC glutamate synthase FOE78_02065 ENOG4105ETE Transcriptional regulator (LacI family FOE78_02110 ENOG4105E7D Protein of unknown function (DUF3375) FOE78_02130 ENOG4105HDK L-asparaginase FOE78_02150 ENOG4105CVR type I restriction-modification system FOE78_02155 ENOG41082EK Restriction modification system DNA (Specificity FOE78_02165 ENOG4105DZR Type I site-specific deoxyribonuclease FOE78_02180 ENOG4105D5G Transposase FOE78_02190 ENOG4105F5W AtP-binding protein FOE78_02225 ENOG4105M6F mutator MutT protein FOE78_02255 ENOG4105RSG Anti-sigma-K factor RskA FOE78_02275 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOE78_02290 ENOG4105E98 transcriptional regulator DeoR family FOE78_02300 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOE78_02305 ENOG4108IJG ABC transporter substrate-binding protein FOE78_02320 ENOG4108HKT sucrose-6-phosphate hydrolase FOE78_02325 ENOG4105CPQ Dehydrogenase FOE78_02330 ENOG4105CQF Transcriptional regulator FOE78_02340 ENOG4107R16 Multicopper oxidase FOE78_02355 ENOG4105CIG ABC transporter FOE78_02360 ENOG4105DIM ABC transporter FOE78_02365 ENOG4105UQX Mate efflux family protein FOE78_02375 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FOE78_02385 ENOG4105CHU acetyl-coa acetyltransferase FOE78_02390 ENOG4105CS1 NAD(P)H quinone oxidoreductase FOE78_02430 ENOG4105CJN penicillin-binding protein FOE78_02445 ENOG4105HZM Fha domain containing protein FOE78_02450 ENOG4105TV9 FHA Domain-Containing protein FOE78_02450 ENOG4105TV9 FHA Domain-Containing protein FOE78_02460 ENOG4105CH2 amidohydrolase FOE78_02480 ENOG4105DBE peroxidase FOE78_02485 ENOG410650H (LipO)protein FOE78_02515 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FOE78_02540 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FOE78_02545 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOE78_02560 ENOG4105CEU Arginine dihydrolase FOE78_02565 ENOG4105CKK Glycosyl transferase, family 2 FOE78_02580 ENOG4105FDK ABC transporter FOE78_02595 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FOE78_02615 ENOG4105CBD Diacylglycerol kinase FOE78_02620 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FOE78_02625 ENOG4108KP7 hydrolase FOE78_02650 ENOG4105BZ1 (ABC) transporter FOE78_02655 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FOE78_02660 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FOE78_02675 ENOG4108KGH TRANSCRIPTIONal FOE78_02685 ENOG4107T65 Integrase FOE78_02690 ENOG4106CY5 excisionase FOE78_02700 ENOG4105CNU cell division protein FtsK FOE78_02735 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOE78_02750 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FOE78_02765 ENOG4105BZ1 (ABC) transporter FOE78_02770 ENOG4105BZ1 (ABC) transporter FOE78_02780 ENOG4107P7U Inherit from COG: Protein of unknown function (DUF433) FOE78_02785 ENOG4108Q5F Tetr family transcriptional regulator FOE78_02795 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) FOE78_02830 ENOG4105CNU cell division protein FtsK FOE78_02905 ENOG4105E4C Lytic transglycosylase catalytic FOE78_02960 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOE78_02965 ENOG4105C26 Dehydrogenase FOE78_02980 ENOG4107SET aldo keto reductase FOE78_02985 ENOG4105EMU Dehydrogenase FOE78_03010 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOE78_03015 ENOG41061MV Arylsulfatase FOE78_03020 ENOG4105CMR udp-glucose 4-epimerase FOE78_03060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOE78_03080 ENOG4105CSU acyl-Coa dehydrogenase FOE78_03085 ENOG4107SIQ Naphthoate synthase FOE78_03090 ENOG4108UN4 phage SPO1 DNA polymerase-related protein FOE78_03095 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FOE78_03105 ENOG4108Z6B deaminase FOE78_03125 ENOG4105D5G Transposase FOE78_03155 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOE78_03160 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOE78_03165 ENOG4105DJY efflux transporter, rnd family, mfp subunit FOE78_03175 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FOE78_03240 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FOE78_03270 ENOG4105CFH Aspartokinase FOE78_03315 ENOG4105C5S asparaginyl-tRNA synthetase FOE78_03415 ENOG4107RGJ metallophosphoesterase FOE78_03425 ENOG4105BZ4 penicillin-binding protein FOE78_03435 ENOG4105D0U Arsenite-activated ATPase (ArsA) FOE78_03470 ENOG4105C0H protease FOE78_03485 ENOG4107QX9 Thiol disulfide interChange protein FOE78_03490 ENOG4105P8F nudix hydrolase FOE78_03505 ENOG4108IUX (ABC) transporter FOE78_03510 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_03535 ENOG4105BZU Histidine kinase FOE78_03545 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FOE78_03550 ENOG41082VC UPF0145 protein FOE78_03555 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOE78_03625 ENOG4108I5C dEAD DEAH box helicase FOE78_03630 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for FOE78_03645 ENOG4105DQ5 transport system permease protein FOE78_03650 ENOG4105TVJ transport system, permease FOE78_03655 ENOG4105E0A ABC, transporter FOE78_03670 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOE78_03690 ENOG4107Z3H Transcriptional regulator, TetR family FOE78_03695 ENOG4105CJ1 ABC, transporter FOE78_03705 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOE78_03710 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOE78_03720 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FOE78_03735 ENOG4105C6E dna polymerase iii FOE78_03750 ENOG4105MA4 psp1 domain protein FOE78_03755 ENOG4106JDR secreted FOE78_03865 ENOG4105CNT hydrolase family 2 FOE78_03870 ENOG4105CS9 pantothenic acid kinase FOE78_03875 ENOG4105YVS arsR family transcriptional regulator FOE78_03885 ENOG4107MM9 BNR Asp-box repeat-containing protein FOE78_03900 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) FOE78_03905 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) FOE78_03930 ENOG4107T8Q Glycosyl transferase (Group 1 FOE78_03960 ENOG4107YJ4 chain length determinant protein FOE78_03970 ENOG4105D3Q Sugar transferase FOE78_03980 ENOG4105I82 acetyl xylan esterase FOE78_03995 ENOG4105F0N pyrophosphate phospho-hydrolase FOE78_04020 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOE78_04030 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOE78_04040 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOE78_04050 ENOG4105EUJ GTP cyclohydrolase i FOE78_04055 ENOG4105FBN Acid phosphatase FOE78_04060 ENOG4105EEI dihydropteroate synthase FOE78_04090 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOE78_04095 ENOG4105FDP GntR family transcriptional regulator FOE78_04100 ENOG4105DVE abc transporter atp-binding protein FOE78_04120 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOE78_04125 ENOG4105CI2 imidazolone-5-propionate hydrolase FOE78_04130 ENOG4107AQZ Membrane FOE78_04135 ENOG4105CTU Proline racemase FOE78_04145 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOE78_04155 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOE78_04170 ENOG4105CV8 reductase FOE78_04210 ENOG4105DQU oxidoreductase, subunit beta FOE78_04215 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOE78_04220 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOE78_04225 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOE78_04230 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOE78_04250 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOE78_04255 ENOG4105CXK mandelate racemase muconate lactonizing FOE78_04260 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FOE78_04280 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FOE78_04285 ENOG4105E2D ec 3.2.1.52 FOE78_04300 ENOG4105EZR dyp-type peroxidase family protein FOE78_04325 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOE78_04340 ENOG4108DWA Nad synthetase FOE78_04370 ENOG4105D5G Transposase FOE78_04380 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) FOE78_04395 ENOG4105RYD Toxic component of a toxin-antitoxin (TA) module. A FOE78_04405 ENOG4108VPT UPF0234 protein FOE78_04410 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOE78_04425 ENOG4105ETE Transcriptional regulator (LacI family FOE78_04440 ENOG4105DRS transport system, permease FOE78_04485 ENOG4105JXH GntR family transcriptional regulator FOE78_04490 ENOG4105DJB Major Facilitator Superfamily FOE78_04495 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOE78_04525 ENOG4105ETE Transcriptional regulator (LacI family FOE78_04540 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOE78_04545 ENOG4105EG2 ABC transporter, permease FOE78_04555 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FOE78_04560 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOE78_04565 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOE78_04665 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOE78_04695 ENOG4105D5G Transposase FOE78_04705 ENOG4105F5W AtP-binding protein FOE78_04730 ENOG4105D5G Transposase FOE78_04805 ENOG4107URF beta-phospho-glucomutase FOE78_04820 ENOG4107QIZ NADH dehydrogenase FOE78_05010 ENOG4105DR5 peptidase FOE78_05025 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FOE78_05040 ENOG4105DRS transport system, permease FOE78_05050 ENOG4105ETE Transcriptional regulator (LacI family FOE78_05055 ENOG4105CHR reductase FOE78_05065 ENOG4105E39 Enoyl-CoA hydratase FOE78_05075 ENOG4105C5I Dehydrogenase FOE78_05090 ENOG4105ETE Transcriptional regulator (LacI family FOE78_05100 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOE78_05105 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FOE78_05125 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOE78_05130 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component FOE78_05135 ENOG4105FDP GntR family transcriptional regulator FOE78_05155 ENOG4105DKQ ROK family FOE78_05160 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) FOE78_05180 ENOG4105RHY Pfam:UPF0157 FOE78_05195 ENOG4105VEQ Cold shock protein FOE78_05215 ENOG4107WNA Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOE78_05245 ENOG4105VEQ Cold shock protein FOE78_05250 ENOG4105EYF MMPL domain protein FOE78_05255 ENOG4105ENE Histidine kinase FOE78_05260 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_05265 ENOG4105C57 major facilitator superfamily FOE78_05280 ENOG4105D5G Transposase FOE78_05290 ENOG41089UC methyltransferase, type 11 FOE78_05320 ENOG4105DFH Transport of potassium into the cell (By similarity) FOE78_05325 ENOG410834F Transcriptional regulator FOE78_05405 ENOG4105CGD Nad-dependent epimerase dehydratase FOE78_05420 ENOG4105CVN desaturase FOE78_05445 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FOE78_05450 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOE78_05465 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOE78_05540 ENOG4105BZ1 (ABC) transporter FOE78_05560 ENOG4105BZ1 (ABC) transporter FOE78_05565 ENOG4105BZ1 (ABC) transporter FOE78_05580 ENOG4105DKQ ROK family FOE78_05585 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) FOE78_05605 ENOG4105E2T synthase III FOE78_05610 ENOG410680H amp-dependent synthetase and ligase FOE78_05615 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOE78_05625 ENOG4105CPQ Dehydrogenase FOE78_05640 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOE78_05650 ENOG4106517 Short-chain dehydrogenase reductase Sdr FOE78_05665 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) FOE78_05670 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOE78_05685 ENOG4105WDJ 50S ribosomal protein L33 FOE78_05695 ENOG410900P UPF0336 protein FOE78_05705 ENOG4107R4N Cell wall formation (By similarity) FOE78_05715 ENOG4105CEY Amp-dependent synthetase and ligase FOE78_05720 ENOG4105XT2 Transcriptional regulator FOE78_05725 ENOG4107SFI Major Facilitator superfamily FOE78_05735 ENOG410683Z Preprotein translocase SecE subunit FOE78_05740 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOE78_05745 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FOE78_05750 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FOE78_05760 ENOG4105C3U ABC transporter FOE78_05765 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOE78_05770 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOE78_05785 ENOG4105K4H Nlp p60 protein FOE78_05795 ENOG4108VZM 50s ribosomal protein L10 FOE78_05800 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FOE78_05810 ENOG4105VCT ion-transport protein YfeO FOE78_05835 ENOG4105DND Transcriptional regulator FOE78_05840 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOE78_05845 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOE78_05855 ENOG4105E5T Major Facilitator Superfamily FOE78_05860 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FOE78_05870 ENOG4105KT7 mgtC SapB transporter FOE78_05895 ENOG4108KGH TRANSCRIPTIONal FOE78_05910 ENOG4107S5I aldo keto reductase FOE78_05915 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FOE78_05920 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FOE78_05925 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FOE78_05930 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FOE78_05950 ENOG4105E0A ABC, transporter FOE78_05955 ENOG4105EHG Permease protein FOE78_05985 ENOG4108M15 ABC transporter FOE78_05995 ENOG4105BZU Histidine kinase FOE78_06000 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_06010 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FOE78_06015 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FOE78_06020 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FOE78_06025 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FOE78_06030 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FOE78_06035 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FOE78_06040 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FOE78_06045 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FOE78_06050 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FOE78_06055 ENOG41082SA 50s ribosomal protein l29 FOE78_06060 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FOE78_06065 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FOE78_06070 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FOE78_06075 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FOE78_06080 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FOE78_06085 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FOE78_06090 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOE78_06095 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FOE78_06100 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FOE78_06105 ENOG410849U 50S ribosomal protein L30 FOE78_06110 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FOE78_06120 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FOE78_06155 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FOE78_06170 ENOG4105EHZ conserved protein UCP016719 FOE78_06185 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FOE78_06190 ENOG41067V7 50S ribosomal protein L36 FOE78_06195 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FOE78_06200 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FOE78_06205 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FOE78_06210 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOE78_06215 ENOG4108ZT0 50S ribosomal protein l17 FOE78_06230 ENOG4105BZN citrate synthase FOE78_06250 ENOG4105CHP RNA polymerase FOE78_06255 ENOG4105GRZ Ycii-related protein FOE78_06260 ENOG4108JQ7 (ABC) transporter FOE78_06270 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOE78_06275 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOE78_06285 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) FOE78_06295 ENOG4105CSH Transporter FOE78_06315 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) FOE78_06320 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOE78_06325 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FOE78_06350 ENOG4105C5H ABC transporter FOE78_06375 ENOG4105BZN citrate synthase FOE78_06380 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FOE78_06385 ENOG4108UJD 30S ribosomal protein S9 FOE78_06390 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FOE78_06400 ENOG4105BZU Histidine kinase FOE78_06405 ENOG4105ETX regulatoR FOE78_06415 ENOG4105CS9 pantothenic acid kinase FOE78_06420 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOE78_06425 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FOE78_06435 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOE78_06450 ENOG4105KVH Transcriptional regulator FOE78_06455 ENOG4105C1J atp-dependent rna helicase FOE78_06460 ENOG4108097 ATP-binding protein FOE78_06475 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOE78_06505 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FOE78_06510 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FOE78_06515 ENOG4105D2H Uronic isomerase FOE78_06520 ENOG4105ETE Transcriptional regulator (LacI family FOE78_06525 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOE78_06530 ENOG4107QVP Dehydrogenase FOE78_06545 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_06560 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOE78_06585 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_06605 ENOG410635A Membrane FOE78_06610 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOE78_06635 ENOG4105CMV Succinyl-CoA synthetase subunit beta FOE78_06645 ENOG410667J hydrolase FOE78_06690 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOE78_06705 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOE78_06710 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOE78_06720 ENOG4105BZ1 (ABC) transporter FOE78_06730 ENOG4105C31 Tryptophanyl-tRNA synthetase FOE78_06735 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOE78_06765 ENOG4105EEQ Na H antiporter FOE78_06775 ENOG4105D5P Methylmalonyl-coA mutase FOE78_06785 ENOG4107TFB basic membrane FOE78_06790 ENOG4108JQ9 ABC transporter FOE78_06795 ENOG4105UIB (ABC) transporter FOE78_06820 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FOE78_06825 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOE78_06835 ENOG4105DXB Major Facilitator superfamily FOE78_06850 ENOG4105C26 Dehydrogenase FOE78_06855 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FOE78_06870 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FOE78_06875 ENOG4105BZM domain protein FOE78_06890 ENOG4105C1G acyl-Coa dehydrogenase FOE78_06900 ENOG4105C26 Dehydrogenase FOE78_06930 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain FOE78_06945 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOE78_06955 ENOG4105D2S major facilitator superfamily FOE78_06960 ENOG4108KPW sugar kinase FOE78_06975 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOE78_06980 ENOG4107S1Q Phosphatase FOE78_07010 ENOG4108JIK carboxylase FOE78_07015 ENOG4107R7A Allophanate hydrolase subunit 2 FOE78_07025 ENOG4105E7W lamb ycsf family protein FOE78_07035 ENOG4105C1G acyl-Coa dehydrogenase FOE78_07040 ENOG4107QX3 carboxylase FOE78_07060 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOE78_07070 ENOG4108RG3 short-chain dehydrogenase reductase FOE78_07075 ENOG4106YN8 Prenyltransferase FOE78_07105 ENOG4107WR6 Maf-like protein FOE78_07115 ENOG4106UW1 Major Facilitator superfamily FOE78_07120 ENOG4107Y9U Membrane FOE78_07140 ENOG4105D8K carboxyl transferase FOE78_07155 ENOG4105E39 Enoyl-CoA hydratase FOE78_07175 ENOG4108Z86 Glutamine amidotransferase FOE78_07180 ENOG4105CHR reductase FOE78_07210 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOE78_07215 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOE78_07220 ENOG41060NJ transcriptional regulator FOE78_07255 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FOE78_07270 ENOG4105CRK lysyL-tRNA synthetase FOE78_07275 ENOG4105KME endoribonuclease L-psp FOE78_07300 ENOG4105E2Y ABC, transporter FOE78_07325 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) FOE78_07330 ENOG4107TE5 Lipid kinase FOE78_07335 ENOG4108KGH TRANSCRIPTIONal FOE78_07365 ENOG4105YXB Toxic component of a toxin-antitoxin (TA) module. A FOE78_07380 ENOG4105FDP GntR family transcriptional regulator FOE78_07395 ENOG4105DH8 myo-inositol catabolism FOE78_07400 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FOE78_07410 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FOE78_07415 ENOG4105C26 Dehydrogenase FOE78_07430 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) FOE78_07435 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase FOE78_07440 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FOE78_07490 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FOE78_07520 ENOG4105CPC Aldo Keto reductase FOE78_07525 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FOE78_07550 ENOG4105M4E phosphohistidine phosphatase, SixA FOE78_07555 ENOG4105C9U ATP-dependent DNA helicase RecQ FOE78_07575 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOE78_07610 ENOG4108RWI nicotinamidase FOE78_07620 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FOE78_07625 ENOG4108Q7D Domain of unknown function (DUF2017) FOE78_07685 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOE78_07705 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FOE78_07710 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOE78_07715 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FOE78_07725 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOE78_07735 ENOG4107S1E Beta-lactamase FOE78_07755 ENOG4107S5I aldo keto reductase FOE78_07800 ENOG4106NZI LysR family Transcriptional regulator FOE78_07915 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FOE78_07920 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOE78_07925 ENOG4105CHP RNA polymerase FOE78_07930 ENOG4105GRZ Ycii-related protein FOE78_07960 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FOE78_07975 ENOG4107YH6 single-stranded DNA-binding protein FOE78_07995 ENOG4105I1K ABC transporter FOE78_08005 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FOE78_08030 ENOG4105CQB FAD linked oxidase domain protein FOE78_08055 ENOG4105ETE Transcriptional regulator (LacI family FOE78_08070 ENOG4105DKG l-rhamnose isomerase FOE78_08090 ENOG4105IQ5 FAD linked oxidase domain protein FOE78_08100 ENOG4105CPQ Dehydrogenase FOE78_08110 ENOG4105DNP FAD linked oxidase domain protein FOE78_08115 ENOG4108Z9K Osmotically inducible protein FOE78_08120 ENOG4105D8X mechanosensitive ion channel FOE78_08125 ENOG4105CD3 dihydroorotase FOE78_08130 ENOG4105CXT aspartate transcarbamylase FOE78_08135 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FOE78_08150 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOE78_08165 ENOG4105EGD dinuclear metal center protein, YbgI family FOE78_08175 ENOG4108YZG isomerase FOE78_08200 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOE78_08215 ENOG4107XU6 Glycosyl transferase (Group 1 FOE78_08245 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FOE78_08250 ENOG4107VFR oxidoreductase FOE78_08280 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOE78_08295 ENOG4108V06 Glutathione peroxidase FOE78_08300 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOE78_08305 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOE78_08310 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FOE78_08325 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FOE78_08390 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOE78_08395 ENOG4105D2S major facilitator superfamily FOE78_08400 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOE78_08415 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FOE78_08430 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOE78_08435 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOE78_08440 ENOG4105EG2 ABC transporter, permease FOE78_08455 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FOE78_08460 ENOG4105BZ1 (ABC) transporter FOE78_08465 ENOG4105BZU Histidine kinase FOE78_08470 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_08475 ENOG4105D65 subunit l FOE78_08480 ENOG4105MKQ Monovalent cation H antiporter subunit C FOE78_08485 ENOG4108JPZ Monovalent cation H antiporter subunit D FOE78_08490 ENOG4105SC1 monovalent cation H antiporter subunit E FOE78_08495 ENOG41080TA Multiple resistance and ph regulation protein f FOE78_08500 ENOG4105KJM monovalent cation h antiporter subunit g FOE78_08565 ENOG4107S9F NmrA family FOE78_08610 ENOG4105CNT hydrolase family 2 FOE78_08615 ENOG4105BZ1 (ABC) transporter FOE78_08620 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FOE78_08625 ENOG4105K46 50S ribosomal protein l27 FOE78_08630 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOE78_08635 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOE78_08655 ENOG4105DIA mandelate racemase muconate lactonizing FOE78_08665 ENOG4105DEI Mannitol dehydrogenase FOE78_08680 ENOG41065SU Two-component system sensor kinase FOE78_08720 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOE78_08735 ENOG4105C0D helicase FOE78_08740 ENOG4105ETE Transcriptional regulator (LacI family FOE78_08750 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FOE78_08755 ENOG4105EG2 ABC transporter, permease FOE78_08765 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FOE78_08780 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FOE78_08785 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FOE78_08795 ENOG4105CVJ phosphoglycerate mutase FOE78_08815 ENOG4108MTT Glutamate-rich protein grpB FOE78_08830 ENOG4105CPC Aldo Keto reductase FOE78_08845 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FOE78_08855 ENOG4105C98 muts2 protein FOE78_08860 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FOE78_08940 ENOG4105EV8 ectoine hydroxylase FOE78_08970 ENOG4107Y80 Major Facilitator superfamily FOE78_08995 ENOG4105VCT ion-transport protein YfeO FOE78_09030 ENOG4105DKT Transcriptional regulator FOE78_09050 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate FOE78_09055 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOE78_09115 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FOE78_09120 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FOE78_09125 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FOE78_09135 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) FOE78_09145 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) FOE78_09150 ENOG4105EM7 Selenocysteine-specific translation elongation factor FOE78_09175 ENOG4105FDF Could be involved in DNA repair (By similarity) FOE78_09180 ENOG4108RWP Major Facilitator Superfamily protein FOE78_09220 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_09230 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein FOE78_09235 ENOG4105CSP Major Facilitator Superfamily FOE78_09240 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FOE78_09245 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOE78_09250 ENOG4105CAS nag kinase FOE78_09255 ENOG4105C8Y Acetylornithine aminotransferase FOE78_09260 ENOG4105DBV ornithine carbamoyltransferase FOE78_09265 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FOE78_09270 ENOG4105CH7 arginosuccinase FOE78_09275 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOE78_09325 ENOG4107RBJ symporter FOE78_09340 ENOG41081R7 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOE78_09345 ENOG4105ETE Transcriptional regulator (LacI family FOE78_09355 ENOG4105C2J ABC transporter FOE78_09360 ENOG4107RNG ABC transporter FOE78_09370 ENOG4108Z0R Transferase FOE78_09400 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FOE78_09415 ENOG4105EEI dihydropteroate synthase FOE78_09420 ENOG4105DKQ ROK family FOE78_09435 ENOG4107JBM CrcB-like protein FOE78_09440 ENOG41083TI Protein CrcB homolog FOE78_09465 ENOG4106N8J Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) FOE78_09485 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FOE78_09500 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOE78_09505 ENOG4105CMR udp-glucose 4-epimerase FOE78_09515 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOE78_09530 ENOG4108ZHR arsR family transcriptional regulator FOE78_09540 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FOE78_09560 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FOE78_09565 ENOG4105C8T Leucyl-tRNA synthetase FOE78_09570 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FOE78_09585 ENOG4105KQC Competence protein FOE78_09590 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOE78_09595 ENOG4105DRR Transcriptional regulator, GntR family FOE78_09600 ENOG4105DZC cytosine deaminase FOE78_09630 ENOG4105CZJ Aldehyde dehydrogenase FOE78_09635 ENOG4108JGH Tetr family transcriptional regulator FOE78_09640 ENOG4105C7K acetolactate synthase FOE78_09650 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FOE78_09655 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FOE78_09660 ENOG4105CBG Sulfatase FOE78_09665 ENOG4105CJQ hydrolase, family 31 FOE78_09670 ENOG4105ETE Transcriptional regulator (LacI family FOE78_09675 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FOE78_09720 ENOG4105F6J Alpha beta hydrolase fold FOE78_09725 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOE78_09740 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FOE78_09750 ENOG4105MC2 DSBA oxidoreductase FOE78_09755 ENOG4105DSF transport protein FOE78_09760 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) FOE78_09765 ENOG4105C1B dTDP-glucose 4-6-dehydratase FOE78_09775 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOE78_09825 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FOE78_09830 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FOE78_09840 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FOE78_09865 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FOE78_09880 ENOG4105CSH Transporter FOE78_09890 ENOG4105CG3 alpha amylase, catalytic region FOE78_09905 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FOE78_09915 ENOG4105CUV Homoserine Kinase FOE78_09925 ENOG4105DDC Oxidoreductase domain protein FOE78_09930 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FOE78_09935 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOE78_09940 ENOG410769Z extracellular solute-binding protein family 1 FOE78_09950 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) FOE78_09955 ENOG4106NZI LysR family Transcriptional regulator FOE78_09965 ENOG4105EQX glucarate dehydratase FOE78_09970 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOE78_09990 ENOG4105FDK ABC transporter FOE78_09995 ENOG4105DSE periplasmic solute binding protein FOE78_10015 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FOE78_10050 ENOG410905P Pyridoxamine 5-phosphate FOE78_10055 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FOE78_10080 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FOE78_10095 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FOE78_10130 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOE78_10135 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOE78_10140 ENOG4105NFY transcriptional modulator of maze toxin, mazf FOE78_10145 ENOG4106FC9 Protein of unknown function (DUF3018) FOE78_10165 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase FOE78_10180 ENOG4105CPC Aldo Keto reductase FOE78_10205 ENOG4105D5U fad dependent oxidoreductase FOE78_10210 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOE78_10230 ENOG4105DQF Hydrolase FOE78_10240 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOE78_10250 ENOG4107QVM von Willebrand factor, type A FOE78_10255 ENOG4107QVM von Willebrand factor, type A FOE78_10280 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOE78_10310 ENOG4105DFA alanine racemase domain protein FOE78_10355 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOE78_10360 ENOG4105CI2 imidazolone-5-propionate hydrolase FOE78_10370 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOE78_10385 ENOG4105E4C Lytic transglycosylase catalytic FOE78_10395 ENOG4105CE9 30S ribosomal protein S2 FOE78_10400 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FOE78_10405 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOE78_10410 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FOE78_10450 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FOE78_10480 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FOE78_10515 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOE78_10520 ENOG4105DZP Membrane-associated zinc metalloprotease FOE78_10525 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FOE78_10530 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOE78_10545 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FOE78_10555 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) FOE78_10565 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FOE78_10575 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FOE78_10575 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FOE78_10580 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FOE78_10585 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOE78_10600 ENOG4105DE4 1-phosphofructokinase FOE78_10620 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FOE78_10625 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FOE78_10630 ENOG4105C1V Peptidase, M16 FOE78_10660 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FOE78_10675 ENOG4105CN5 Metallo-Beta-Lactamase FOE78_10680 ENOG4105VB9 50S ribosomal protein l28 FOE78_10685 ENOG4105DWF phosphomethylpyrimidine kinase FOE78_10695 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FOE78_10700 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FOE78_10715 ENOG4106H78 methyltransferase FOE78_10720 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FOE78_10735 ENOG41084BZ 50S ribosomal protein L32 FOE78_10740 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FOE78_10745 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOE78_10825 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FOE78_10830 ENOG4105K5M 30s ribosomal protein S16 FOE78_10835 ENOG41082KU UPF0109 protein FOE78_10840 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FOE78_10845 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FOE78_10870 ENOG41062D9 Histidine kinase FOE78_10875 ENOG4105ETX regulatoR FOE78_10915 ENOG4105E33 succinate dehydrogenase FOE78_10920 ENOG4105E2R ROK family FOE78_10930 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOE78_10945 ENOG4108JQ7 (ABC) transporter FOE78_10965 ENOG4105C5H ABC transporter FOE78_10975 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FOE78_10985 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOE78_11005 ENOG4105D82 Glutamate dehydrogenase FOE78_11010 ENOG4105CPC Aldo Keto reductase FOE78_11015 ENOG41080R2 UPF0102 protein FOE78_11020 ENOG4105C0P Mg chelatase subunit ChlI FOE78_11045 ENOG4105D7K pfkb domain protein FOE78_11050 ENOG4105D7K pfkb domain protein FOE78_11055 ENOG4108UHU Aldolase FOE78_11060 ENOG41060NJ transcriptional regulator FOE78_11070 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FOE78_11075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOE78_11080 ENOG4105BZU Histidine kinase FOE78_11085 ENOG4105G3P Lipoprotein lpqB FOE78_11090 ENOG4105MJ2 Competence protein FOE78_11100 ENOG4105DRS transport system, permease FOE78_11105 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FOE78_11110 ENOG4105CZQ inner membrane transport protein YdhC FOE78_11135 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOE78_11150 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea FOE78_11180 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOE78_11185 ENOG4105EEM helicase FOE78_11195 ENOG4105DIA mandelate racemase muconate lactonizing FOE78_11200 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase FOE78_11215 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) FOE78_11230 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FOE78_11235 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOE78_11240 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOE78_11265 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_11275 ENOG4107T5V SNARE associated Golgi FOE78_11280 ENOG4105CK5 oxidoreductase FOE78_11300 ENOG4105FDF Could be involved in DNA repair (By similarity) FOE78_11305 ENOG4105C26 Dehydrogenase FOE78_11325 ENOG4105C7I Dehydrogenase FOE78_11330 ENOG4107TXC Transcriptional regulator FOE78_11360 ENOG4105DB7 PHP domain protein FOE78_11375 ENOG4105C1J atp-dependent rna helicase FOE78_11430 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FOE78_11435 ENOG4106J7G oxidoreductase FOE78_11440 ENOG4108KFM Xylose Isomerase Domain-Containing protein FOE78_11460 ENOG4108NQD FOE78_11465 ENOG4105VEQ Cold shock protein FOE78_11475 ENOG4105EAC phosphoserine phosphatase FOE78_11490 ENOG4105C4R Atp-dependent dna helicase FOE78_11495 ENOG4105C4R Atp-dependent dna helicase FOE78_11510 ENOG4105CAT Cytidine monophosphate kinase FOE78_11520 ENOG4105D9G High-affinity FOE78_11525 ENOG4105C7H Helicase, RecD TraA family FOE78_11530 ENOG4107QKA exodeoxyribonuclease V beta FOE78_11565 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FOE78_11610 ENOG4107S5I aldo keto reductase FOE78_11635 ENOG41063PX domain protein FOE78_11645 ENOG4105DJZ UPF0182 protein FOE78_11670 ENOG4107RAN Peptidase, M16 FOE78_11675 ENOG4108VCA G U mismatch-specific DNA glycosylase FOE78_11685 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOE78_11710 ENOG4105E6M Sulphatase-modifying factor protein FOE78_11720 ENOG41061MV Arylsulfatase FOE78_11755 ENOG4105CK5 oxidoreductase FOE78_11760 ENOG4108JQ1 Dehydrogenase FOE78_11775 ENOG4105CQ7 ATP-dependent helicase FOE78_11790 ENOG4105NFY transcriptional modulator of maze toxin, mazf FOE78_11795 ENOG4105C29 acyl-CoA thioesterase FOE78_11855 ENOG41082JN Transcriptional regulator FOE78_11885 ENOG4105SHT UspA domain-containing protein FOE78_11890 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOE78_11910 ENOG4105H3G oxidoreductase FOE78_11915 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FOE78_11920 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FOE78_11935 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase FOE78_11940 ENOG4105ECY inositol monophosphatase FOE78_11955 ENOG4105C3U ABC transporter FOE78_11980 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOE78_11990 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOE78_11995 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FOE78_12005 ENOG4105E6M Sulphatase-modifying factor protein FOE78_12035 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FOE78_12045 ENOG4105ETE Transcriptional regulator (LacI family FOE78_12055 ENOG4106FRU abrb family transcriptional regulator FOE78_12065 ENOG4107W53 thymidine kinase FOE78_12080 ENOG4107S1E Beta-lactamase FOE78_12085 ENOG4105KHC sulfurtransferase FOE78_12090 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOE78_12105 ENOG4107KWJ von Willebrand factor, type A FOE78_12130 ENOG4105CGF Aromatic amino acid aminotransferase FOE78_12140 ENOG4105DJZ UPF0182 protein FOE78_12145 ENOG4105EY8 ABC transporter FOE78_12150 ENOG4105MFV ABC-2 type transporter FOE78_12165 ENOG4105EXC Acyl-transferase FOE78_12175 ENOG4107SJB teichoic acid biosynthesis FOE78_12250 ENOG4105T16 Transcriptional regulator (AraC family) FOE78_12290 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FOE78_12295 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOE78_12310 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOE78_12315 ENOG4105BZW Glycerate kinase FOE78_12320 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOE78_12365 ENOG4107VEG TrkA-N domain protein FOE78_12370 ENOG4105C0X amino acid FOE78_12375 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOE78_12390 ENOG4107QM5 aconitate hydratase FOE78_12395 ENOG4105EMU Dehydrogenase FOE78_12405 ENOG4105CV8 reductase FOE78_12420 ENOG4105CPC Aldo Keto reductase FOE78_12490 ENOG4105BZU Histidine kinase FOE78_12495 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_12530 ENOG4107RGD Major Facilitator superfamily FOE78_12540 ENOG4105PAD Hydrolase FOE78_12545 ENOG4105CK5 oxidoreductase FOE78_12555 ENOG4105DKQ ROK family FOE78_12575 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOE78_12580 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FOE78_12585 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOE78_12590 ENOG4105CHU acetyl-coa acetyltransferase FOE78_12605 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOE78_12610 ENOG4105C1Q protoporphyrinogen oxidase FOE78_12615 ENOG4107JTW chlorite dismutase FOE78_12620 ENOG4105E0X reductase FOE78_12625 ENOG4105DQE DNA ligase FOE78_12640 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) FOE78_12645 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FOE78_12670 ENOG4105KXX peptidase s58 dmpa FOE78_12680 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOE78_12690 ENOG4105DEF Extracellular solute-binding protein, family 5 FOE78_12710 ENOG4105C2J ABC transporter FOE78_12715 ENOG4105CNN ABC, transporter FOE78_12720 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOE78_12725 ENOG4105CMT Dihydroxyacetone kinase FOE78_12730 ENOG4107YVI ribose 5-phosphate isomerase FOE78_12735 ENOG4105CP7 Triose-phosphate isomerase FOE78_12760 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FOE78_12765 ENOG4105DRS transport system, permease FOE78_12780 ENOG4105DRS transport system, permease FOE78_12785 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) FOE78_12825 ENOG4105CTX dehydratase FOE78_12835 ENOG4108PCN EamA-like transporter family FOE78_12840 ENOG4105C22 threonyL-tRNA synthetase FOE78_12855 ENOG4108VTU Cdp-alcohol phosphatidyltransferase FOE78_12865 ENOG4105E2K Glycosyl transferase (Group 1 FOE78_12890 ENOG4108UW8 fha domain-containing protein FOE78_12915 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FOE78_12920 ENOG4105KZX Pterin carbinolamine dehydratase FOE78_12930 ENOG4108JQ7 (ABC) transporter FOE78_12940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOE78_12960 ENOG4107H3J ribonuclease FOE78_12965 ENOG4108MES Periplasmic binding protein FOE78_12970 ENOG4107RJF diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90) FOE78_12975 ENOG4108Z4X TRANSCRIPTIONal FOE78_12980 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOE78_12985 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOE78_12990 ENOG4105CSH Transporter FOE78_12995 ENOG4107RTD sua5 ycio yrdc ywlc family protein FOE78_13000 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOE78_13015 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FOE78_13020 ENOG4105CFC Transporter FOE78_13025 ENOG4107S2Z UPF0761 membrane protein FOE78_13030 ENOG41061ZR Transcriptional regulator FOE78_13035 ENOG4107QWE )-transporter FOE78_13040 ENOG4105C0H protease FOE78_13055 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FOE78_13065 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FOE78_13080 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOE78_13085 ENOG4105C9M aspartyl-trna synthetase FOE78_13105 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FOE78_13110 ENOG4105I1K ABC transporter FOE78_13125 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOE78_13135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOE78_13170 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOE78_13175 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FOE78_13180 ENOG4105HHA aminodeoxychorismate lyase FOE78_13185 ENOG4105E2X shikimate dehydrogenase FOE78_13195 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOE78_13200 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FOE78_13205 ENOG4105D49 3-dehydroquinate synthase FOE78_13215 ENOG4105E4I Glycoside hydrolase family 28 FOE78_13230 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOE78_13235 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FOE78_13250 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FOE78_13255 ENOG410803B Involved in the transcription termination process (By similarity) FOE78_13275 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOE78_13280 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FOE78_13285 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FOE78_13290 ENOG4105SKN orotidine 5''-phosphate decarboxylase FOE78_13310 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FOE78_13315 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FOE78_13325 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FOE78_13340 ENOG4107RSZ Primosomal protein n' FOE78_13345 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FOE78_13360 ENOG4105DJV ribulose-phosphate 3-epimerase FOE78_13375 ENOG4105C3R Methionine synthase FOE78_13380 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FOE78_13395 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) FOE78_13410 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FOE78_13415 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FOE78_13420 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase FOE78_13425 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FOE78_13430 ENOG4105VIE preprotein translocase, subunit YajC FOE78_13435 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOE78_13440 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOE78_13445 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FOE78_13455 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOE78_13470 ENOG4105C99 atpase involved in dna repair FOE78_13475 ENOG4105CUT histidyl-tRNA synthetase FOE78_13500 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FOE78_13510 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FOE78_13535 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_13555 ENOG4105CHH sulfate transporter FOE78_13575 ENOG4105DSF transport protein FOE78_13595 ENOG4105CHH sulfate transporter FOE78_13615 ENOG4105CBG Sulfatase FOE78_13630 ENOG4105C0B DNA polymerase III (alpha subunit) FOE78_13645 ENOG4108PYU two-component system response regulator FOE78_13650 ENOG4108FKE two-component system sensor kinase FOE78_13660 ENOG4105C22 threonyL-tRNA synthetase FOE78_13690 ENOG4105D7N magnesium and cobalt transport protein CorA FOE78_13710 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FOE78_13735 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOE78_13830 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOE78_13875 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOE78_13885 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) FOE78_13900 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOE78_13910 ENOG4105Q70 FOE78_13930 ENOG4105R3A Nitrate reductase FOE78_13935 ENOG4108IUE nitrate reductase beta subunit FOE78_13985 ENOG4105HFS 5'-3' exonuclease FOE78_14020 ENOG4107SJB teichoic acid biosynthesis FOE78_14025 ENOG4105D5G Transposase FOE78_14030 ENOG4107SJB teichoic acid biosynthesis FOE78_14045 ENOG4107SJB teichoic acid biosynthesis FOE78_14055 ENOG4105ETE Transcriptional regulator (LacI family FOE78_14075 ENOG4105JAB phenazine biosynthesis protein, phzf family FOE78_14085 ENOG4108JGH Tetr family transcriptional regulator FOE78_14090 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOE78_14100 ENOG4105CPC Aldo Keto reductase FOE78_14105 ENOG4105C8M UPF0272 protein FOE78_14110 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase FOE78_14120 ENOG4108J9M Transporter FOE78_14135 ENOG4107RGM aldo keto reductase FOE78_14145 ENOG41086KC Transcriptional regulator FOE78_14170 ENOG4105BZP glycoside hydrolase 15-related FOE78_14200 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOE78_14210 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FOE78_14220 ENOG4105CAT Cytidine monophosphate kinase FOE78_14225 ENOG4108R85 Short chain dehydrogenase FOE78_14235 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FOE78_14240 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FOE78_14245 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) FOE78_14260 ENOG4105E5F proteasome FOE78_14270 ENOG4105CVK Glutamate decarboxylase FOE78_14295 ENOG4105DRS transport system, permease FOE78_14300 ENOG4105CDY transcriptional regulatory protein FOE78_14330 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FOE78_14365 ENOG4105D2T synthase FOE78_14375 ENOG4108MRH transcriptional regulatory protein FOE78_14380 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOE78_14385 ENOG4105E2Y ABC, transporter FOE78_14390 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOE78_14410 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FOE78_14415 ENOG4105CIH Imidazole acetol-phosphate transaminase FOE78_14420 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOE78_14425 ENOG4105DWV Homoserine O-trans-acetylase FOE78_14430 ENOG4108Z66 YbaK ebsC protein FOE78_14435 ENOG4105DQE DNA ligase FOE78_14450 ENOG4105C0B DNA polymerase III (alpha subunit) FOE78_14465 ENOG4105CBC glutamate synthase FOE78_14480 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FOE78_14495 ENOG41067D0 Antitoxin component of a toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of toxin RelE2 FOE78_14500 ENOG4105VG9 Plasmid stabilization system FOE78_14525 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FOE78_14530 ENOG4105DK0 Indole-3-glycerol phosphate synthase FOE78_14545 ENOG4105CRQ synthase (Component I) FOE78_14550 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FOE78_14570 ENOG410846T CoA-transferase family III FOE78_14575 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FOE78_14580 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOE78_14585 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FOE78_14615 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FOE78_14630 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOE78_14640 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOE78_14660 ENOG4107UWA esterase FOE78_14675 ENOG4105C10 Electron transfer flavoprotein FOE78_14685 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FOE78_14690 ENOG4105ETE Transcriptional regulator (LacI family FOE78_14730 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) FOE78_14735 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) FOE78_14740 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FOE78_14800 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FOE78_14805 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOE78_14830 ENOG4105E09 nadh pyrophosphatase FOE78_14840 ENOG4105K56 Transcriptional regulator FOE78_14855 ENOG4105CHU acetyl-coa acetyltransferase FOE78_14885 ENOG4105CJ1 ABC, transporter FOE78_14945 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FOE78_14950 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FOE78_14955 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FOE78_14960 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FOE78_14965 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOE78_14970 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FOE78_14975 ENOG4106DE0 ATP synthase FOE78_14980 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) FOE78_15005 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOE78_15025 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOE78_15030 ENOG4105VFB Binds the 23S rRNA (By similarity) FOE78_15040 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FOE78_15045 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FOE78_15050 ENOG4105D6E homoserine dehydrogenase FOE78_15055 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOE78_15060 ENOG4105QPS Monooxygenase FOE78_15085 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOE78_15100 ENOG4105DHU Bile acid FOE78_15115 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FOE78_15130 ENOG4105ETE Transcriptional regulator (LacI family FOE78_15180 ENOG4105C3U ABC transporter FOE78_15185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOE78_15200 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOE78_15295 ENOG4105ETE Transcriptional regulator (LacI family FOE78_15320 ENOG4105DQ4 alcohol dehydrogenase FOE78_15325 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FOE78_15335 ENOG4105E5Q amino acid AbC transporter FOE78_15340 ENOG4105CDA abc transporter atp-binding protein FOE78_15350 ENOG4105DTQ mandelate racemase muconate lactonizing FOE78_15380 ENOG4105CPC Aldo Keto reductase FOE78_15395 ENOG4105EMN RNA polymerase sigma factor FOE78_15425 ENOG4108RAV Conserved protein FOE78_15435 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FOE78_15440 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOE78_15445 ENOG4107TK4 histidinol-phosphate phosphatase FOE78_15450 ENOG4105CXK mandelate racemase muconate lactonizing FOE78_15455 ENOG4105ME7 Membrane FOE78_15460 ENOG4105D44 asparaginase FOE78_15470 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOE78_15480 ENOG4106NZI LysR family Transcriptional regulator FOE78_15505 ENOG4105C3U ABC transporter FOE78_15510 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOE78_15520 ENOG4108J59 Extracellular solute-binding protein, family 5 FOE78_15550 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOE78_15555 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FOE78_15575 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FOE78_15600 ENOG4105CIR epoxide hydrolase FOE78_15610 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOE78_15620 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FOE78_15635 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FOE78_15645 ENOG4107YEV ferritin FOE78_15650 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOE78_15655 ENOG4107WI4 Aldose-1-epimerase FOE78_15660 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOE78_15665 ENOG4105CDA abc transporter atp-binding protein FOE78_15670 ENOG4107UBR Extracellular solute-binding protein family 3 FOE78_15675 ENOG4108Q1T ABC transporter FOE78_15680 ENOG4105DRP amino acid AbC transporter FOE78_15685 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) FOE78_15715 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FOE78_15720 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FOE78_15740 ENOG4105KC9 Modulates RecA activity (By similarity) FOE78_15745 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FOE78_15750 ENOG4105CSH Transporter FOE78_15755 ENOG4108JPW Aminotransferase FOE78_15790 ENOG4107S4Y M20 DapE family protein YgeY FOE78_15795 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOE78_15800 ENOG4105ENR peptidase, M24 FOE78_15810 ENOG4105C5I Dehydrogenase FOE78_15815 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOE78_15825 ENOG4105ETE Transcriptional regulator (LacI family FOE78_15830 ENOG4105CTZ aminopeptidase c FOE78_15855 ENOG4107QRT dEAD DEAH box helicase FOE78_15865 ENOG4105WBV Transcriptional regulator FOE78_15870 ENOG4105CEV competence damage-inducible protein FOE78_15880 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FOE78_15895 ENOG4107RGD Major Facilitator superfamily FOE78_15900 ENOG4107QZI cell division protein FtsK FOE78_15905 ENOG4108J59 Extracellular solute-binding protein, family 5 FOE78_15915 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOE78_15920 ENOG4105C3U ABC transporter FOE78_15925 ENOG4108JQ7 (ABC) transporter FOE78_15955 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOE78_15975 ENOG4105CPN adenine deaminase FOE78_15980 ENOG4105CSV Glutaminase FOE78_16000 ENOG4105DSF transport protein FOE78_16025 ENOG4105CPF Cell wall formation (By similarity) FOE78_16030 ENOG4105C28 cystathionine FOE78_16040 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FOE78_16050 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FOE78_16055 ENOG4105CEY Amp-dependent synthetase and ligase FOE78_16065 ENOG4105K70 DNA-binding protein FOE78_16070 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOE78_16075 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOE78_16080 ENOG41069M3 Transcriptional regulator FOE78_16110 ENOG4107FCW Abortive infection protein FOE78_16115 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FOE78_16120 ENOG4105ERH Fumarylacetoacetate hydrolase FOE78_16140 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FOE78_16150 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FOE78_16155 ENOG4105CNT hydrolase family 2 FOE78_16160 ENOG4105E09 nadh pyrophosphatase FOE78_16165 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOE78_16170 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOE78_16185 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOE78_16190 ENOG4108ZP8 Acetolactate synthase small subunit FOE78_16205 ENOG4105CNN ABC, transporter FOE78_16210 ENOG4105C2J ABC transporter FOE78_16215 ENOG4105SHT UspA domain-containing protein FOE78_16230 ENOG4108U8T Mannosyltransferase FOE78_16235 ENOG4105K59 histidine triad (HIT) protein FOE78_16240 ENOG4105F9U Dehydrogenase FOE78_16245 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FOE78_16260 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase FOE78_16270 ENOG4105CQR helicase FOE78_16280 ENOG4105VTW prevent-host-death family FOE78_16290 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOE78_16295 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FOE78_16315 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FOE78_16330 ENOG4108V1T peptidylprolyl cis-trans isomerase FOE78_16335 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) FOE78_16345 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FOE78_16350 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FOE78_16375 ENOG4105DCF alanine dehydrogenase FOE78_16380 ENOG4105DU0 nucleoside hydrolase FOE78_16415 ENOG4107VIJ nudix hydrolase FOE78_16420 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FOE78_16470 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOE78_16490 ENOG4105DSU hydrolase FOE78_16510 ENOG4105E98 transcriptional regulator DeoR family FOE78_16560 ENOG4106NZI LysR family Transcriptional regulator FOE78_16570 ENOG4105D5G Transposase FOE78_16585 ENOG4107U32 Beta-lactamase domain protein FOE78_16600 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOE78_16605 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FOE78_16625 ENOG4108RWN rrna methyltransferase FOE78_16630 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FOE78_16635 ENOG41084BS 50S ribosomal protein L35 FOE78_16640 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOE78_16660 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FOE78_16665 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase FOE78_16675 ENOG4105C8N cysteinyl-tRNA synthetase FOE78_16700 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOE78_16705 ENOG4105DYW oxidoreductase FOE78_16710 ENOG4105CPC Aldo Keto reductase FOE78_16725 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FOE78_16760 ENOG41081JD Transcriptional regulator FOE78_16765 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOE78_16775 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FOE78_16785 ENOG4105EN6 Membrane FOE78_16825 ENOG4105DRS transport system, permease FOE78_16840 ENOG4105BZU Histidine kinase FOE78_16845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOE78_16850 ENOG4105DEF Extracellular solute-binding protein, family 5 FOE78_16860 ENOG4108JQ7 (ABC) transporter FOE78_16865 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOE78_16880 ENOG4105CHU acetyl-coa acetyltransferase FOE78_16890 ENOG4107QNJ CoA-transferase subunit B FOE78_16920 ENOG4105CEY Amp-dependent synthetase and ligase FOE78_16925 ENOG4105C0H protease FOE78_16930 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FOE78_16950 ENOG4108JJB ABC transporter FOE78_16965 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FOE78_16970 ENOG4106KNT transcriptional regulator FOE78_16980 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FOE78_16985 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FOE78_16990 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FOE78_17010 ENOG4108UJU UPF0301 protein FOE78_17020 ENOG4105ETE Transcriptional regulator (LacI family FOE78_17060 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FOE78_17085 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FOE78_17095 ENOG4105C31 Tryptophanyl-tRNA synthetase FOE78_17100 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FOE78_17105 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase FOE78_17125 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) FOE78_17130 ENOG4105CAK Cell division ATP-binding protein ftsE FOE78_17140 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FOE78_17145 ENOG4105E2R ROK family FOE78_17160 ENOG4105CHR reductase FOE78_17170 ENOG4105EKQ RNA-directed DNA polymerase FOE78_17195 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FOE78_17205 ENOG4105DDC Oxidoreductase domain protein FOE78_17225 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FOE78_17235 ENOG4105ETE Transcriptional regulator (LacI family FOE78_17240 ENOG4105EFZ amidohydrolase FOE78_17250 ENOG4105CPQ Dehydrogenase FOE78_17280 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FOE78_17295 ENOG4105DCG PHP domain protein FOE78_17310 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FOE78_17335 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOE78_17345 ENOG4105F8D glycoside hydrolase family 4 FOE78_17355 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOE78_17360 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOE78_17365 ENOG4105KV4 Transcriptional regulator FOE78_17370 ENOG41087EV Hsp20/alpha crystallin family FOE78_17390 ENOG4105DKW ABC transporter FOE78_17415 ENOG4105CHR reductase FOE78_17430 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOE78_17440 ENOG4105BZ1 (ABC) transporter FOE78_17445 ENOG4105BZ1 (ABC) transporter FOE78_17450 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOE78_17475 ENOG4105CUV Homoserine Kinase FOE78_17490 ENOG4105BZ1 (ABC) transporter FOE78_17500 ENOG4105C5H ABC transporter FOE78_17530 ENOG4105CHR reductase FOE78_17540 ENOG4105DIA mandelate racemase muconate lactonizing FOE78_17550 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) FOE78_17555 ENOG4105CHR reductase FOE78_17605 ENOG4108JPZ Monovalent cation H antiporter subunit D FOE78_17615 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOE78_17620 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction FOE78_17625 ENOG4105BZP glycoside hydrolase 15-related FOE78_17655 ENOG4107QNK )-transporter FOE78_17660 ENOG4105C54 Major Facilitator superfamily FOE78_17675 ENOG4105VG1 fes assembly suf system protein FOE78_17685 ENOG4105C9B Cysteine desulfurase FOE78_17690 ENOG4105C3K feS assembly ATPase SufC FOE78_17750 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FOE78_17760 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOE78_17775 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) FOE78_17795 ENOG4105D5G Transposase FOE78_17845 ENOG4105CP7 Triose-phosphate isomerase FOE78_17850 ENOG4105BZA Phosphoglycerate kinase FOE78_17860 ENOG4105CIE May be required for sporulation (By similarity) FOE78_17875 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FOE78_17885 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOE78_17890 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FOE78_17895 ENOG4108RZE Tetr family transcriptional regulator FOE78_17900 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOE78_17905 ENOG4108UHU Aldolase FOE78_17915 ENOG4108UDB Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOE78_17920 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOE78_17935 ENOG4108IG5 Transcriptional regulator FOE78_17960 ENOG4105CHP RNA polymerase FOE78_17965 ENOG4105GRZ Ycii-related protein FOE78_17970 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOE78_17985 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOE78_17990 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FOE78_17995 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOE78_18025 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_18030 ENOG4108ZGX Histidine kinase FOE78_18045 ENOG4105CAZ oligogalacturonide lyase FOE78_18050 ENOG4105CX8 fg-gap repeat protein FOE78_18055 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FOE78_18065 ENOG4105E0S extracellular solute-binding protein family 1 FOE78_18075 ENOG4105ETE Transcriptional regulator (LacI family FOE78_18090 ENOG4105KA0 thioesterase Superfamily protein FOE78_18095 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOE78_18105 ENOG4108IV0 ABC, transporter FOE78_18110 ENOG4105C0Z ABC transporter FOE78_18115 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOE78_18120 ENOG4105C32 Amino acid ABC transporter (Permease) FOE78_18140 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOE78_18180 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FOE78_18185 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOE78_18190 ENOG4105ME9 cell division protein FtsQ FOE78_18195 ENOG4105DFU Cell wall formation (By similarity) FOE78_18200 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOE78_18210 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FOE78_18215 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FOE78_18225 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOE78_18230 ENOG4105CJN penicillin-binding protein FOE78_18240 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FOE78_18245 ENOG4108V6E Cell division protein mraZ FOE78_18250 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOE78_18270 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOE78_18290 ENOG4105EWK phytoene FOE78_18295 ENOG4105EEM helicase FOE78_18315 ENOG4105EBM Alpha Beta Hydrolase Fold protein FOE78_18330 ENOG4105MHT Transcriptional regulator, ARSR family FOE78_18355 ENOG4105ETE Transcriptional regulator (LacI family FOE78_18370 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FOE78_18395 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOE78_18410 ENOG4105F5W AtP-binding protein FOE78_18435 ENOG4105E8R UPF0173 metal-dependent hydrolase FOE78_18440 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase FOE78_18470 ENOG4105C57 major facilitator superfamily FOE78_18475 ENOG4105DUX Transporter FOE78_18485 ENOG4105DKQ ROK family FOE78_18515 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOE78_18540 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) FOE78_18565 ENOG4107S1N anthranilate phosphoribosyltransferase FOE78_18575 ENOG4105CCU oxidase (Subunit III) FOE78_18580 ENOG4107UDY cytochrome C FOE78_18585 ENOG4107EUI c reductase, iron-sulfur FOE78_18590 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOE78_18610 ENOG4105CHF Glutathione S-transferase FOE78_18675 ENOG4108ZRS Part of cytochrome c oxidase, its function is FOE78_18680 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOE78_18685 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FOE78_18710 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOE78_18715 ENOG4105C01 Dihydroxy-acid dehydratase FOE78_18735 ENOG4105CPC Aldo Keto reductase FOE78_18745 ENOG4105DEN Luciferase family FOE78_18765 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FOE78_18770 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FOE78_18795 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FOE78_18820 ENOG4108VQT Alpha beta hydrolase fold protein FOE78_18850 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FOE78_18865 ENOG4105C5H ABC transporter FOE78_18870 ENOG4108ZJ4 polysaccharide deacetylase FOE78_18880 ENOG4105CQB FAD linked oxidase domain protein FOE78_18905 ENOG4105CJ1 ABC, transporter FOE78_18915 ENOG4105C5R Aminotransferase FOE78_18920 ENOG4105CPC Aldo Keto reductase FOE78_18925 ENOG4105C5F glutamine synthetase FOE78_18940 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOE78_18990 ENOG4105BZ4 penicillin-binding protein FOE78_18995 ENOG4105BZ4 penicillin-binding protein FOE78_19000 ENOG4105C26 Dehydrogenase FOE78_19005 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FOE78_19010 ENOG4105BZP glycoside hydrolase 15-related FOE78_19015 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FOE78_19025 ENOG4105C8V SAICAR synthetase FOE78_19055 ENOG4105ENH Sulfatase FOE78_19095 ENOG4107TXC Transcriptional regulator FOE78_19140 ENOG4105KRQ Addiction module toxin, Txe YoeB family FOE78_19155 ENOG4105KVH Transcriptional regulator FOE78_19160 ENOG4105CS1 NAD(P)H quinone oxidoreductase FOE78_19165 ENOG4105F2Z 3-oxoadipate enol-lactonase FOE78_19205 ENOG4105DZC cytosine deaminase FOE78_19220 ENOG4107R1Q Membrane protein FdrA FOE78_19225 ENOG4107REC cytoplasmic protein FOE78_19230 ENOG4105N16 Protein of unknown function (DUF2877) FOE78_19235 ENOG4105C5B carbamate kinase FOE78_19240 ENOG4105C5B carbamate kinase FOE78_19245 ENOG4105CI2 imidazolone-5-propionate hydrolase FOE78_19255 ENOG4105CWN amidohydrolase FOE78_19260 ENOG4105DZC cytosine deaminase FOE78_19265 ENOG4107SNB ankyrin repeat protein YahD FOE78_19295 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOE78_19300 ENOG4105FBN Acid phosphatase FOE78_19305 ENOG4105CI2 imidazolone-5-propionate hydrolase FOE78_19315 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FOE78_19320 ENOG4105ETS cytosine purines uracil thiamine allantoin FOE78_19325 ENOG4105CGP Urocanate hydratase FOE78_19330 ENOG4105C84 Histidine ammonia-lyase FOE78_19350 ENOG4105CUB amino acid FOE78_19360 ENOG4108UMI ABC transporter, permease FOE78_19365 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOE78_19370 ENOG4105D01 (LipO)protein FOE78_19405 ENOG4105CIR epoxide hydrolase FOE78_19410 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FOE78_19445 ENOG4105D5G Transposase FOE78_19460 ENOG4105CJ1 ABC, transporter FOE78_19500 ENOG4105CHR reductase FOE78_19520 ENOG4105CHH sulfate transporter FOE78_19525 ENOG4107TXC Transcriptional regulator FOE78_19550 ENOG4105C2C drug resistance transporter, Bcr CflA FOE78_19555 ENOG4108ZM9 phosphoglycerate mutase FOE78_19565 ENOG4107T6F Xaa-Pro aminopeptidase FOE78_19585 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_19590 ENOG4105BZU Histidine kinase FOE78_19600 ENOG4105CJW magnesium transporter FOE78_19610 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FOE78_19630 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FOE78_19635 ENOG4105C0H protease FOE78_19650 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOE78_19660 ENOG4107ZBN O-methyltransferase FOE78_19665 ENOG4105RYD Toxic component of a toxin-antitoxin (TA) module. A FOE78_19675 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOE78_19680 ENOG4107QPH glycogen) synthase FOE78_19705 ENOG4108R3E Dna-3-methyladenine glycosylase i FOE78_19720 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) FOE78_19765 ENOG4105D17 glycoside hydrolase, family 3 domain protein FOE78_19775 ENOG4108Z4U Ferredoxin FOE78_19800 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) FOE78_19815 ENOG4108JQ7 (ABC) transporter FOE78_19820 ENOG4105C3U ABC transporter FOE78_19825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOE78_19830 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOE78_19835 ENOG4105DEF Extracellular solute-binding protein, family 5 FOE78_19860 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_19865 ENOG4108KPJ rna polymerase sigma factor FOE78_19895 ENOG4105CUJ penicillin amidase FOE78_19900 ENOG4108URH decarboxylase FOE78_19935 ENOG4105C3G gtp-binding protein FOE78_19945 ENOG4105DFM M18 family aminopeptidase FOE78_19950 ENOG4105CGY Dna recombination protein FOE78_19955 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FOE78_19970 ENOG4108JGH Tetr family transcriptional regulator FOE78_19975 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FOE78_19980 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FOE78_19985 ENOG4105ECQ AraC Family Transcriptional Regulator FOE78_20000 ENOG4105C9Q fumarate hydratase class II FOE78_20020 ENOG4108IAB Phoh family FOE78_20030 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOE78_20050 ENOG4105C7Z Conserved Protein FOE78_20055 ENOG4105CUB amino acid FOE78_20075 ENOG4107S5I aldo keto reductase FOE78_20110 ENOG4105C01 Dihydroxy-acid dehydratase FOE78_20115 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FOE78_20125 ENOG4105BZ7 extracellular solute-binding protein family 1 FOE78_20130 ENOG41061MV Arylsulfatase FOE78_20135 ENOG4107QTZ amino acid FOE78_20155 ENOG4105JXH GntR family transcriptional regulator FOE78_20165 ENOG4105T1M mycothiol conjugate amidase mca FOE78_20175 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FOE78_20200 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FOE78_20210 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOE78_20215 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FOE78_20245 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOE78_20250 ENOG4105CHP RNA polymerase FOE78_20285 ENOG4105C34 Pseudouridine synthase FOE78_20290 ENOG4105DC1 bifunctional purine biosynthesis protein purh FOE78_20310 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOE78_20315 ENOG4105VUC UPF0237 protein FOE78_20335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOE78_20345 ENOG4107QSI ABC, transporter FOE78_20355 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FOE78_20405 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOE78_20410 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FOE78_20415 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOE78_20420 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FOE78_20460 ENOG4108SKZ Patatin-like phospholipase FOE78_20465 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FOE78_20475 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FOE78_20480 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FOE78_20485 ENOG4106839 domain protein FOE78_20490 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase FOE78_20495 ENOG4105F8V Hydrolase, tatD family FOE78_20515 ENOG4105C2J ABC transporter FOE78_20520 ENOG4105CNN ABC, transporter FOE78_20535 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_20545 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FOE78_20570 ENOG4108UZX fmn reductase FOE78_20590 ENOG4105F32 YngK protein FOE78_20600 ENOG4105KPY Small multidrug resistance protein FOE78_20680 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOE78_20700 ENOG4105CHR reductase FOE78_20710 ENOG4105D5G Transposase FOE78_20745 ENOG4105EPU Molybdenum cofactor synthesis domain protein FOE78_20750 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOE78_20760 ENOG4105DQE DNA ligase FOE78_20765 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase FOE78_20770 ENOG4105CHP RNA polymerase FOE78_20790 ENOG4105EXC Acyl-transferase FOE78_20800 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FOE78_20805 ENOG4108IYU L-aspartate oxidase FOE78_20825 ENOG4105KVH Transcriptional regulator FOE78_20845 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOE78_20870 ENOG4105CUJ penicillin amidase FOE78_20900 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOE78_20905 ENOG4107QR9 Iron-sulfur cluster binding protein FOE78_20910 ENOG41080R8 Conserved Protein FOE78_20915 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FOE78_20940 ENOG4105HMI Membrane FOE78_20970 ENOG41080RH Thioredoxin FOE78_20975 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOE78_20990 ENOG4105CE4 GlcNAc 6-P deacetylase FOE78_21005 ENOG4105E98 transcriptional regulator DeoR family FOE78_21060 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FOE78_21065 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FOE78_21080 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FOE78_21100 ENOG4105CBG Sulfatase FOE78_21105 ENOG4105CZQ inner membrane transport protein YdhC FOE78_21135 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOE78_21185 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOE78_21190 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOE78_21200 ENOG4108JQ6 ABC transporter FOE78_21235 ENOG4107Y80 Major Facilitator superfamily FOE78_21245 ENOG4108VHT MarR family transcriptional regulator FOE78_21255 ENOG4105E93 esterase FOE78_21280 ENOG4108N0W Major Facilitator superfamily FOE78_21295 ENOG4105CSR polyphosphate kinase 2 FOE78_21300 ENOG4105C7N Xanthine uracil vitamin C permease FOE78_21305 ENOG4105VEQ Cold shock protein FOE78_21315 ENOG4105E8G Major facilitator Superfamily FOE78_21345 ENOG4105CFI type iii restriction protein res subunit FOE78_21375 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOE78_21380 ENOG4105EEM helicase FOE78_21390 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOE78_21400 ENOG4106N3A copper homeostasis protein cutc FOE78_21410 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOE78_21415 ENOG4105KXI murein peptide amidase A FOE78_21425 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FOE78_21430 ENOG4105F5W AtP-binding protein FOE78_21470 ENOG4105CQB FAD linked oxidase domain protein FOE78_21495 ENOG4105C9U ATP-dependent DNA helicase RecQ FOE78_21500 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOE78_21545 ENOG4105D9R oxidoreductase FOE78_21550 ENOG4105EIP mannose-6-phosphate isomerase FOE78_21555 ENOG4105C5I Dehydrogenase FOE78_21585 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FOE78_21600 ENOG4105CEY Amp-dependent synthetase and ligase FOE78_21620 ENOG4108UVJ appr-1-p processing domain protein FOE78_21640 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOE78_21645 ENOG4105CPQ Dehydrogenase FOE78_21650 ENOG4105EJQ L-serine dehydratase FOE78_21655 ENOG4108IJ9 (ABC) transporter FOE78_21675 ENOG4105C1G acyl-Coa dehydrogenase FOE78_21685 ENOG4105C8N cysteinyl-tRNA synthetase FOE78_21695 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FOE78_21705 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOE78_21710 ENOG4105NPE arsR family transcriptional regulator FOE78_21715 ENOG4108MR6 WD40-like Beta Propeller Repeat FOE78_21720 ENOG4105VEQ Cold shock protein FOE78_21730 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FOE78_21750 ENOG4105ETE Transcriptional regulator (LacI family FOE78_21755 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) FOE78_21760 ENOG4105CHR reductase FOE78_21780 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOE78_21795 ENOG4106NDP Transcriptional regulator FOE78_21800 ENOG4108Z4K mutator MutT protein FOE78_21805 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FOE78_21815 ENOG4105CGZ zinc metallopeptidase FOE78_21820 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FOE78_21825 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FOE78_21830 ENOG4108VJ1 Transcriptional regulator (CarD family FOE78_21840 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOE78_21870 ENOG4105BZU Histidine kinase FOE78_21875 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOE78_21880 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOE78_21895 ENOG4107QNK )-transporter FOE78_21900 ENOG4108YZJ Pfam:DUF2596 FOE78_21915 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FOE78_21925 ENOG4105DQE DNA ligase FOE78_21950 ENOG4105CI3 gtp-binding protein typa FOE78_21990 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FOE78_21995 ENOG4108SVG May play a role in the intracellular transport of hydrophobic ligands FOE78_22010 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FOE78_22020 ENOG4105PKJ carbohydrate binding FOE78_22025 ENOG4105KHC sulfurtransferase FOE78_22035 ENOG4107NHD transcriptional regulator FOE78_22065 ENOG4105DRS transport system, permease FOE78_22095 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOE78_22100 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOE78_22150 ENOG4105CSR polyphosphate kinase 2 FOE78_22160 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FOE78_22175 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOE78_22180 ENOG4105RHY Pfam:UPF0157 FOE78_22210 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) FOE78_22220 ENOG4105RHY Pfam:UPF0157 FOE78_22240 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOE78_22255 ENOG4105CRE cytochrome C FOE78_22265 ENOG4107QIV Cytochrome c biogenesis protein FOE78_22270 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOE78_22275 ENOG4108RH7 phosphoglycerate mutase FOE78_22280 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FOE78_22285 ENOG4105D52 delta-aminolevulinic acid dehydratase FOE78_22310 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FOE78_22315 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FOE78_22320 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FOE78_22340 ENOG4108IUE nitrate reductase beta subunit FOE78_22360 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) FOE78_22370 ENOG4108RXW HAD-superfamily subfamily IB hydrolase FOE78_22380 ENOG4105PGM cation diffusion facilitator family transporter FOE78_22385 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) FOE78_22390 ENOG4105C01 Dihydroxy-acid dehydratase FOE78_22395 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_22400 ENOG4105BZU Histidine kinase FOE78_22425 ENOG4105CEY Amp-dependent synthetase and ligase FOE78_22450 ENOG4105DGU Histone deacetylase FOE78_22455 ENOG4105II7 pyrroline-5-carboxylate reductase FOE78_22470 ENOG4105EY0 Xylose isomerase domain protein TIM barrel FOE78_22475 ENOG4108JWX FOE78_22485 ENOG4105CIH Imidazole acetol-phosphate transaminase FOE78_22505 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOE78_22510 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FOE78_22520 ENOG4107VUZ FOE78_22550 ENOG4105C1B dTDP-glucose 4-6-dehydratase FOE78_22555 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOE78_22560 ENOG4105CPC Aldo Keto reductase FOE78_22565 ENOG4105C9K Endothelin-converting enzyme 1 FOE78_22580 ENOG4105C57 major facilitator superfamily FOE78_22605 ENOG4108IJ7 Glycine betaine FOE78_22610 ENOG4105CIB oxidoreductase Domain protein FOE78_22615 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FOE78_22625 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FOE78_22650 ENOG4108KPJ rna polymerase sigma factor FOE78_22660 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FOE78_22675 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOE78_22690 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOE78_22695 ENOG4105DF2 NADH dehydrogenase subunit j FOE78_22705 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FOE78_22710 ENOG4108IEH NADH dehydrogenase subunit g FOE78_22725 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOE78_22730 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOE78_22735 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOE78_22745 ENOG4105P52 geranylgeranyl reductase FOE78_22755 ENOG4105E4F Isochorismate synthase FOE78_22765 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOE78_22770 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOE78_22785 ENOG4105WBV Transcriptional regulator FOE78_22810 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOE78_22815 ENOG4107TCW O-succinylbenzoate synthase FOE78_22825 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOE78_22830 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FOE78_22850 ENOG41083NF Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FOE78_22860 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FOE78_22865 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOE78_22880 ENOG4105D4Y metalloprotease FOE78_22895 ENOG4105D94 Major Facilitator Superfamily FOE78_22915 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component FOE78_22920 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component FOE78_22940 ENOG4108PVQ transcriptional regulator FOE78_22980 ENOG4105K4H Nlp p60 protein FOE78_23005 ENOG4105KVH Transcriptional regulator FOE78_23045 ENOG4105CXB phosphoribosylaminoimidazole synthetase FOE78_23070 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FOE78_23075 ENOG4105BZ1 (ABC) transporter FOE78_23080 ENOG4105BZ1 (ABC) transporter FOE78_23085 ENOG4105WH1 Two component transcriptional regulator luxr family FOE78_23090 ENOG4105BZU Histidine kinase FOE78_23105 ENOG4105CMQ Chloride channel FOE78_23110 ENOG4105DIA mandelate racemase muconate lactonizing FOE78_23115 ENOG4107QIK phosphoribosylformylglycinamidine synthase FOE78_23120 ENOG4105MHT Transcriptional regulator, ARSR family FOE78_23140 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FOE78_23145 ENOG410839H phosphoribosylformylglycinamidine synthase FOE78_23155 ENOG4105CE1 Ferrous iron transport protein b FOE78_23165 ENOG4105C8V SAICAR synthetase FOE78_23185 ENOG4105CJ1 ABC, transporter FOE78_23215 ENOG4105VMP Transcriptional regulator FOE78_23225 ENOG4105C83 adenylosuccinate lyase FOE78_23230 ENOG4105C12 Phosphoribosylglycinamide synthetase FOE78_23240 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FOE78_23265 ENOG4105FDP GntR family transcriptional regulator FOE78_23270 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOE78_23290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOE78_23295 ENOG4108HH4 Major Facilitator Superfamily FOE78_23300 ENOG4105C87 Aminotransferase class I and II FOE78_23310 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN FOE78_23320 ENOG4107SET aldo keto reductase FOE78_23325 ENOG4108V0P LemA family FOE78_23330 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FOE78_23335 ENOG4108U4N (sortase) family FOE78_23365 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOE78_23370 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOE78_23380 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOE78_23395 ENOG4105CPC Aldo Keto reductase FOE78_23400 ENOG4105DRR Transcriptional regulator, GntR family FOE78_23405 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FOE78_23410 ENOG4105DJB Major Facilitator Superfamily FOE78_23420 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FOE78_23425 ENOG4108I5D sulfate abc transporter FOE78_23430 ENOG4105ECW sulfate abc transporter FOE78_23435 ENOG4108IJ6 ABC transporter FOE78_23450 ENOG4105KNI merR family transcriptional Regulator FOE78_23455 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FOE78_23460 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ