locus-tag	class	description
MCR_0001	ENOG4105VG0	50S ribosomal protein l34
MCR_0003	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
MCR_0005	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
MCR_0006	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
MCR_0009	ENOG4105K6T	rare lipoprotein A
MCR_0011	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
MCR_0012	ENOG4105JKW	Valine--pyruvate aminotransferase
MCR_0013	ENOG4105M4H	endoribonuclease L-psp
MCR_0016	ENOG4105BZ1	(ABC) transporter
MCR_0017	ENOG4105CH7	arginosuccinase
MCR_0018	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
MCR_0020	ENOG4105C2N	RNA methyltransferase TrmH family group 3
MCR_0022	ENOG4105CFG	Acts as a chaperone (By similarity)
MCR_0031	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
MCR_0034	ENOG4105DFU	Cell wall formation (By similarity)
MCR_0035	ENOG41080I0	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
MCR_0036	ENOG4105D9M	gamma-glutamylcysteine synthetase
MCR_0037	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
MCR_0040	ENOG4105D7T	ABC transporter
MCR_0044	ENOG4105C5H	ABC transporter
MCR_0045	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
MCR_0046	ENOG4105DNZ	Alpha Beta Hydrolase
MCR_0047	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
MCR_0048	ENOG4105C28	cystathionine
MCR_0049	ENOG4105C09	Bile acid
MCR_0050	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
MCR_0053	ENOG4105I08	Pseudouridine synthase
MCR_0055	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
MCR_0057	ENOG4105C34	Pseudouridine synthase
MCR_0058	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
MCR_0059	ENOG4105CKI	cobalamin synthesis protein
MCR_0060	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
MCR_0066	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
MCR_0067	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
MCR_0068	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
MCR_0069	ENOG4105E33	succinate dehydrogenase
MCR_0071	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
MCR_0072	ENOG4105C7S	Dehydrogenase
MCR_0076	ENOG4105UGU	tonB-dependent Receptor
MCR_0084	ENOG4105DGW	oligopeptidase A
MCR_0085	ENOG4105X23	Endonuclease Exonuclease phosphatase
MCR_0087	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
MCR_0088	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
MCR_0089	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
MCR_0090	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
MCR_0091	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
MCR_0092	ENOG4105CHU	acetyl-coa acetyltransferase
MCR_0097	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
MCR_0098	ENOG4105CB5	ATP-dependent DNA helicase recG
MCR_0106	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
MCR_0107	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
MCR_0109	ENOG4107QHF	type ii secretion system protein e
MCR_0110	ENOG4105E5M	Multidrug resistance protein D
MCR_0112	ENOG4108ETH	Formylglycinamide ribotide synthetase
MCR_0114	ENOG4105D6U	Sodium Glutamate Symporter
MCR_0115	ENOG4107QZM	n-acetylglutamate synthase
MCR_0119	ENOG410650H	(LipO)protein
MCR_0120	ENOG4105DBE	peroxidase
MCR_0121	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
MCR_0124	ENOG4105CBC	glutamate synthase
MCR_0126	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
MCR_0127	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
MCR_0128	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
MCR_0130	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
MCR_0131	ENOG4105DSQ	Nitric oxide reductase
MCR_0135	ENOG4105CEI	nitrite reductase
MCR_0140	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
MCR_0141	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
MCR_0142	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
MCR_0143	ENOG4105NRA	50s ribosomal protein l31 type b
MCR_0144	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
MCR_0145	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
MCR_0146	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
MCR_0149	ENOG4105C1J	atp-dependent rna helicase
MCR_0150	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
MCR_0154	ENOG4105C6T	cysteine synthase
MCR_0156	ENOG4105BZU	Histidine kinase
MCR_0158	ENOG4105DJ4	phosphatidylserine decarboxylase
MCR_0159	ENOG4105WD1	Membrane
MCR_0161	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
MCR_0162	ENOG41090JN	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
MCR_0163	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
MCR_0164	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
MCR_0166	ENOG4105P8F	nudix hydrolase
MCR_0168	ENOG4107X4V	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
MCR_0169	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
MCR_0170	ENOG4108UUM	single-stranded DNA-binding protein
MCR_0171	ENOG4106032	Glutathionylspermidine synthase
MCR_0173	ENOG41060IM	Heme exporter protein
MCR_0174	ENOG4105X3C	heme exporter protein
MCR_0175	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
MCR_0176	ENOG4105D01	(LipO)protein
MCR_0177	ENOG4108UMI	ABC transporter, permease
MCR_0178	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
MCR_0180	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
MCR_0184	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
MCR_0185	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
MCR_0188	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
MCR_0191	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
MCR_0194	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
MCR_0196	ENOG4105CVE	Lytic murein transglycosylase
MCR_0197	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
MCR_0198	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
MCR_0199	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
MCR_0200	ENOG4105CKW	Inner membrane protein yedI
MCR_0206	ENOG4105CIN	aminoacyl-histidine dipeptidase
MCR_0208	ENOG4108ZZ3	UPF0260 protein
MCR_0209	ENOG4108JU5	Magnesium and cobalt efflux protein
MCR_0210	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
MCR_0211	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
MCR_0212	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
MCR_0213	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
MCR_0219	ENOG4108MVK	Receptor
MCR_0220	ENOG4108R0G	Tetratricopeptide repeat protein
MCR_0223	ENOG4105CRQ	synthase (Component I)
MCR_0226	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
MCR_0227	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
MCR_0229	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
MCR_0230	ENOG4105C3M	thioredoxin reductase
MCR_0231	ENOG4105CSU	acyl-Coa dehydrogenase
MCR_0233	ENOG4105E2X	shikimate dehydrogenase
MCR_0236	ENOG4105HHA	aminodeoxychorismate lyase
MCR_0237	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
MCR_0238	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
MCR_0240	ENOG4105C8V	SAICAR synthetase
MCR_0241	ENOG4105EGD	dinuclear metal center protein, YbgI family
MCR_0250	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
MCR_0251	ENOG4105PM1	preprotein translocase subunit SecE
MCR_0252	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
MCR_0253	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
MCR_0254	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
MCR_0256	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
MCR_0257	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
MCR_0258	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
MCR_0259	ENOG4108JQ1	Dehydrogenase
MCR_0260	ENOG4105DC8	reductase
MCR_0264	ENOG4105CN1	protease
MCR_0266	ENOG4105HF0	Membrane
MCR_0268	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
MCR_0270	ENOG4108UKZ	OsmC family
MCR_0273	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
MCR_0275	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
MCR_0276	ENOG4105CE9	30S ribosomal protein S2
MCR_0277	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
MCR_0279	ENOG4105D7Z	glutathione synthase
MCR_0280	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
MCR_0282	ENOG4105D9U	N-acetyltransferase
MCR_0283	ENOG4105DFU	Cell wall formation (By similarity)
MCR_0284	ENOG4105CPF	Cell wall formation (By similarity)
MCR_0286	ENOG4105C5Q	Transcriptional regulator
MCR_0287	ENOG4105D3R	alkyl hydroperoxide reductase
MCR_0292	ENOG4105WVQ	Fe-S assembly protein IscX
MCR_0295	ENOG4107QKW	extracellular solute-binding protein family 1
MCR_0296	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
MCR_0298	ENOG4108W2W	
MCR_0300	ENOG4105D6S	protein involved in catabolism of external DNA
MCR_0301	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
MCR_0302	ENOG4105DQF	Hydrolase
MCR_0304	ENOG4108X4Q	Hydrolase
MCR_0305	ENOG4107T5V	SNARE associated Golgi
MCR_0306	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
MCR_0307	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
MCR_0308	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
MCR_0310	ENOG4105Y3E	Modulates RecA activity (By similarity)
MCR_0311	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
MCR_0314	ENOG4105CQB	FAD linked oxidase domain protein
MCR_0319	ENOG4105CUZ	uba thif-type nad fad binding protein
MCR_0320	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
MCR_0323	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
MCR_0325	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
MCR_0327	ENOG4105E9K	Isocitrate dehydrogenase
MCR_0328	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
MCR_0330	ENOG4105DZ2	Transcriptional regulator
MCR_0331	ENOG4105DQR	SNARE associated Golgi
MCR_0332	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
MCR_0333	ENOG41090R7	Ferric uptake
MCR_0335	ENOG4105CZX	twitching motility protein
MCR_0336	ENOG4105DFA	alanine racemase domain protein
MCR_0342	ENOG4105DTN	riboflavin biosynthesis protein ribF
MCR_0343	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
MCR_0346	ENOG4105C25	Primosomal protein n'
MCR_0347	ENOG4105EZR	dyp-type peroxidase family protein
MCR_0348	ENOG4105KME	endoribonuclease L-psp
MCR_0350	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
MCR_0351	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
MCR_0352	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
MCR_0354	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
MCR_0355	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
MCR_0356	ENOG4105EN6	Membrane
MCR_0358	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
MCR_0359	ENOG4108JPW	Aminotransferase
MCR_0360	ENOG4107QMH	DNA methylase
MCR_0362	ENOG4105DY8	decarboxylase
MCR_0363	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
MCR_0365	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
MCR_0367	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
MCR_0368	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MCR_0370	ENOG4105FAV	ABC, transporter
MCR_0371	ENOG4105FDK	ABC transporter
MCR_0372	ENOG4105MYN	Zinc uptake regulation protein
MCR_0376	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
MCR_0377	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
MCR_0378	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
MCR_0379	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
MCR_0380	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
MCR_0381	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
MCR_0383	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
MCR_0384	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
MCR_0385	ENOG4107EXC	regulatoR
MCR_0386	ENOG4105JJR	Histidine kinase
MCR_0387	ENOG4105E0F	Histidine kinase
MCR_0388	ENOG4105K5M	30s ribosomal protein S16
MCR_0389	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
MCR_0390	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
MCR_0391	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
MCR_0394	ENOG4107QIJ	Aconitate hydratase 2
MCR_0395	ENOG4105CGP	Urocanate hydratase
MCR_0396	ENOG4105C84	Histidine ammonia-lyase
MCR_0397	ENOG41088SP	formiminoglutamate hydrolase
MCR_0398	ENOG4105CI2	imidazolone-5-propionate hydrolase
MCR_0400	ENOG4105BZJ	Electron transfer flavoprotein
MCR_0401	ENOG4105C10	Electron transfer flavoprotein
MCR_0403	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MCR_0404	ENOG4105CXT	aspartate transcarbamylase
MCR_0406	ENOG4105CD3	dihydroorotase
MCR_0407	ENOG4105CI0	Citrate lyase
MCR_0408	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
MCR_0410	ENOG4105IPI	Membrane
MCR_0412	ENOG4108UPT	UPF0178 protein
MCR_0413	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
MCR_0414	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
MCR_0416	ENOG4105DR9	pseudouridine synthase
MCR_0417	ENOG4108YXA	Membrane
MCR_0420	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
MCR_0426	ENOG4105K8R	UPF0145 protein
MCR_0429	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
MCR_0430	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
MCR_0431	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
MCR_0435	ENOG4105HBR	Rna-binding protein
MCR_0436	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
MCR_0437	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
MCR_0439	ENOG4108JQC	penicillin-binding protein 1A
MCR_0440	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
MCR_0445	ENOG4105C4W	S-formylglutathione hydrolase
MCR_0452	ENOG4105CUB	amino acid
MCR_0454	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
MCR_0455	ENOG4105C6K	Malic enzyme
MCR_0456	ENOG4105D52	delta-aminolevulinic acid dehydratase
MCR_0458	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
MCR_0461	ENOG4105CHR	reductase
MCR_0464	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
MCR_0466	ENOG4105C01	Dihydroxy-acid dehydratase
MCR_0469	ENOG4105C02	permease
MCR_0471	ENOG4105K59	histidine triad (HIT) protein
MCR_0472	ENOG4105DP0	ferredoxin-NADP reductase
MCR_0473	ENOG4108R96	Methyltransferase, YaeB family
MCR_0474	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
MCR_0475	ENOG4105BZS	acriflavin resistance protein
MCR_0476	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
MCR_0478	ENOG4105CQB	FAD linked oxidase domain protein
MCR_0479	ENOG4105CFP	Peptidase U32
MCR_0483	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
MCR_0485	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
MCR_0486	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
MCR_0488	ENOG4105D6E	homoserine dehydrogenase
MCR_0489	ENOG4105T95	Thiol disulfide interChange protein
MCR_0491	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
MCR_0492	ENOG4105X58	receptor
MCR_0495	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
MCR_0496	ENOG4105DWV	Homoserine O-trans-acetylase
MCR_0497	ENOG4108YZY	peptidylprolyl cis-trans isomerase
MCR_0499	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
MCR_0500	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
MCR_0504	ENOG4105C2W	permease
MCR_0505	ENOG4105BZG	amino acid carrier protein
MCR_0506	ENOG4105N2G	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MCR_0510	ENOG4108Z4U	Ferredoxin
MCR_0512	ENOG4105CJR	Integral membrane protein (MviN
MCR_0513	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
MCR_0516	ENOG4107QPK	)-transporter
MCR_0517	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
MCR_0519	ENOG4108HED	Type II restriction
MCR_0522	ENOG4105DGU	Histone deacetylase
MCR_0525	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
MCR_0526	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
MCR_0530	ENOG4105M08	Membrane
MCR_0531	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
MCR_0535	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
MCR_0537	ENOG4105CV1	Transketolase (EC 2.2.1.1)
MCR_0539	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
MCR_0540	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
MCR_0541	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
MCR_0542	ENOG4105KNE	Phosphatidate cytidylyltransferase
MCR_0543	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
MCR_0544	ENOG4105DZP	Membrane-associated zinc metalloprotease
MCR_0546	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MCR_0547	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
MCR_0548	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
MCR_0549	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
MCR_0550	ENOG4105C8J	)-transporter
MCR_0552	ENOG4105C4M	(Ubiquinol oxidase) subunit I
MCR_0553	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
MCR_0555	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
MCR_0558	ENOG4105BZG	amino acid carrier protein
MCR_0568	ENOG4108RCM	Nitroreductase
MCR_0569	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
MCR_0571	ENOG4105G2Y	Transcriptional regulator
MCR_0572	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
MCR_0573	ENOG4105K46	50S ribosomal protein l27
MCR_0576	ENOG4105C02	permease
MCR_0577	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
MCR_0578	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
MCR_0580	ENOG4105W0E	50S ribosomal protein L33
MCR_0581	ENOG4105KDC	50s ribosomal protein l28
MCR_0583	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
MCR_0584	ENOG4105CFH	Aspartokinase
MCR_0587	ENOG4105DUX	Transporter
MCR_0591	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
MCR_0594	ENOG4107QTF	adenylosuccinate lyase
MCR_0596	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
MCR_0597	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
MCR_0600	ENOG4105M2J	Glutaredoxin
MCR_0603	ENOG4108ZIT	Ferredoxin, 2FE-2S
MCR_0605	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
MCR_0606	ENOG4108Z4V	iron-sulfur cluster assembly
MCR_0607	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
MCR_0609	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
MCR_0612	ENOG4105K70	DNA-binding protein
MCR_0613	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
MCR_0614	ENOG4105DC1	bifunctional purine biosynthesis protein purh
MCR_0617	ENOG4105EUR	Domain-Containing protein
MCR_0617	ENOG4105EUR	Domain-Containing protein
MCR_0621	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
MCR_0623	ENOG4105SBG	acid phosphatase
MCR_0625	ENOG4105BZ4	penicillin-binding protein
MCR_0626	ENOG4105C59	p-type ATPase
MCR_0629	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
MCR_0632	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
MCR_0637	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
MCR_0642	ENOG4105CGZ	zinc metallopeptidase
MCR_0645	ENOG4105K3M	)-transporter
MCR_0650	ENOG4105D60	lipoprotein releasing system transmembrane protein
MCR_0651	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
MCR_0654	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
MCR_0656	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
MCR_0658	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
MCR_0661	ENOG4105CX6	glutaminyL-tRNA synthetase
MCR_0662	ENOG4107QUV	Domain protein
MCR_0663	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
MCR_0664	ENOG410863D	Flavinator of succinate dehydrogenase
MCR_0666	ENOG4105VP5	Bacterial protein of unknown function (DUF937)
MCR_0667	ENOG4108RXW	HAD-superfamily subfamily IB hydrolase
MCR_0677	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
MCR_0681	ENOG4105E4C	Lytic transglycosylase catalytic
MCR_0682	ENOG4105D0M	Protease HtpX homolog
MCR_0683	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
MCR_0684	ENOG4105EEI	dihydropteroate synthase
MCR_0685	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
MCR_0687	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
MCR_0692	ENOG4108R0G	Tetratricopeptide repeat protein
MCR_0695	ENOG4105D64	Mechanosensitive ion channel
MCR_0696	ENOG4105F8V	Hydrolase, tatD family
MCR_0697	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
MCR_0700	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
MCR_0701	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
MCR_0705	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MCR_0708	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
MCR_0709	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
MCR_0712	ENOG4105GKE	subunit e
MCR_0713	ENOG4107QIZ	NADH dehydrogenase
MCR_0714	ENOG4108IEH	NADH dehydrogenase subunit g
MCR_0715	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
MCR_0716	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
MCR_0717	ENOG4107UFS	subunit j
MCR_0719	ENOG4105D65	subunit l
MCR_0720	ENOG4105C8S	subunit m
MCR_0721	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
MCR_0722	ENOG4105EHV	domain protein
MCR_0723	ENOG4105DP0	ferredoxin-NADP reductase
MCR_0725	ENOG4105C75	arginyL-tRNA synthetase
MCR_0726	ENOG41080C8	DUF218 domain
MCR_0727	ENOG4105D4A	Cell wall formation (By similarity)
MCR_0729	ENOG4105VEJ	Heat shock protein
MCR_0732	ENOG4105C7B	Threonine dehydratase
MCR_0733	ENOG4105CDY	transcriptional regulatory protein
MCR_0734	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
MCR_0737	ENOG4107QP7	CoA-transferase subunit A
MCR_0738	ENOG4107QNJ	CoA-transferase subunit B
MCR_0739	ENOG41063SR	receptor
MCR_0741	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
MCR_0745	ENOG41077A9	carbonic anhydrase
MCR_0746	ENOG4105CRU	nitrate reductase, alpha subunit
MCR_0747	ENOG4108IUE	nitrate reductase beta subunit
MCR_0748	ENOG4108NZN	Respiratory nitrate reductase 2 delta chain
MCR_0749	ENOG4105D0D	Nitrate reductase 2, gamma subunit
MCR_0751	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
MCR_0752	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
MCR_0753	ENOG4105E0C	molybdate abc transporter
MCR_0754	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
MCR_0755	ENOG4105F4R	Transcriptional regulator mode
MCR_0757	ENOG4105M00	molybdopterin converting factor, subunit 1
MCR_0758	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
MCR_0760	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
MCR_0761	ENOG4108RPX	mosc domain containing protein
MCR_0762	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
MCR_0763	ENOG4105WH1	Two component transcriptional regulator luxr family
MCR_0764	ENOG4105BZU	Histidine kinase
MCR_0766	ENOG4105DQQ	Major facilitator superfamily MFS_1
MCR_0769	ENOG4105D06	uba thif-type nad fad binding protein
MCR_0787	ENOG4105C26	Dehydrogenase
MCR_0789	ENOG4105K3M	)-transporter
MCR_0790	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
MCR_0791	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
MCR_0794	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
MCR_0795	ENOG4108IYU	L-aspartate oxidase
MCR_0802	ENOG4105D3Y	Na H antiporter
MCR_0803	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
MCR_0804	ENOG4105D7N	magnesium and cobalt transport protein CorA
MCR_0805	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
MCR_0807	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
MCR_0812	ENOG4105CSM	endonuclease III
MCR_0813	ENOG4105DAN	ATP-dependent protease
MCR_0814	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
MCR_0815	ENOG4107QJE	Chromosome Partitioning Protein
MCR_0817	ENOG4105FA0	parb-like partition protein
MCR_0818	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
MCR_0819	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
MCR_0821	ENOG4107QRG	dna polymerase iii
MCR_0822	ENOG4105DMF	Dehydrogenase
MCR_0823	ENOG4105DAA	L-lactate
MCR_0825	ENOG4105CGK	Exodeoxyribonuclease III
MCR_0826	ENOG4105EJ2	Transcriptional regulator
MCR_0830	ENOG4105C3G	gtp-binding protein
MCR_0831	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
MCR_0834	ENOG4105D6Z	AFG1 family ATPase
MCR_0836	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
MCR_0838	ENOG4107YVF	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
MCR_0839	ENOG4105C9A	Phoh family
MCR_0840	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
MCR_0841	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
MCR_0842	ENOG4108URH	decarboxylase
MCR_0843	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
MCR_0844	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
MCR_0845	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
MCR_0846	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
MCR_0847	ENOG4105FE9	pseudouridine synthase
MCR_0848	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
MCR_0849	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
MCR_0850	ENOG4105C31	Tryptophanyl-tRNA synthetase
MCR_0851	ENOG4105DK0	Indole-3-glycerol phosphate synthase
MCR_0852	ENOG4108I0Q	anthranilate phosphoribosyltransferase
MCR_0853	ENOG4105DDQ	anthranilate synthase
MCR_0854	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
MCR_0855	ENOG4105D1S	lipid A biosynthesis
MCR_0856	ENOG4105C5H	ABC transporter
MCR_0857	ENOG4107JHD	SlyX family
MCR_0861	ENOG4105DBV	ornithine carbamoyltransferase
MCR_0866	ENOG4108Z6B	deaminase
MCR_0867	ENOG4105CAT	Cytidine monophosphate kinase
MCR_0868	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
MCR_0869	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
MCR_0871	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
MCR_0872	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
MCR_0873	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
MCR_0874	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
MCR_0875	ENOG4105K9H	YciI-like protein
MCR_0878	ENOG4105E09	nadh pyrophosphatase
MCR_0879	ENOG4107RZZ	dna polymerase iii epsilon subunit
MCR_0880	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
MCR_0883	ENOG4105C12	Phosphoribosylglycinamide synthetase
MCR_0884	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
MCR_0886	ENOG4105VCQ	rubredoxin
MCR_0887	ENOG4105CQC	Prephenate dehydratase
MCR_0888	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
MCR_0889	ENOG4105FR1	rard protein
MCR_0892	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
MCR_0893	ENOG4107QSN	dihydrolipoamide acetyltransferase
MCR_0896	ENOG4108J2H	Sulfate ABC transporter periplasmic sulfate-binding protein
MCR_0897	ENOG4105C28	cystathionine
MCR_0898	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
MCR_0899	ENOG4105XPH	Ferredoxin
MCR_0902	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
MCR_0906	ENOG4105K8N	protein family UPF0079, ATPase
MCR_0907	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
MCR_0908	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
MCR_0909	ENOG4105C2X	Arabinose 5-phosphate isomerase
MCR_0911	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
MCR_0914	ENOG4108IUZ	ABC transporter
MCR_0915	ENOG4105C26	Dehydrogenase
MCR_0921	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
MCR_0923	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
MCR_0925	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
MCR_0927	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
MCR_0929	ENOG4107QKA	exodeoxyribonuclease V beta
MCR_0930	ENOG4107QYX	exodeoxyribonuclease v alpha
MCR_0931	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
MCR_0933	ENOG4107SVC	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
MCR_0934	ENOG4105CSR	polyphosphate kinase 2
MCR_0938	ENOG4108XTP	Transcriptional regulator
MCR_0957	ENOG4105WXW	Antirepressor
MCR_0967	ENOG4105PF0	Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin
MCR_0974	ENOG4107V40	secretion protein, HlyD family
MCR_0976	ENOG4105CQ7	ATP-dependent helicase
MCR_0977	ENOG4105E02	MotA TolQ exbB proton channel
MCR_0978	ENOG4105M8F	Biopolymer transport protein exbD tolR
MCR_0980	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
MCR_0982	ENOG4108JA2	transcriptioN-repair coupling factor
MCR_0983	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
MCR_0992	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
MCR_0994	ENOG4105CSA	Coproporphyrinogen iii oxidase
MCR_0995	ENOG4105C1J	atp-dependent rna helicase
MCR_0997	ENOG4108I5D	sulfate abc transporter
MCR_0998	ENOG4105ECW	sulfate abc transporter
MCR_1000	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
MCR_1003	ENOG4105E9H	Lytic Murein transglycosylase
MCR_1007	ENOG4105VIE	preprotein translocase, subunit YajC
MCR_1008	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
MCR_1009	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
MCR_1010	ENOG41061WM	D-Alanyl-D-Alanine
MCR_1011	ENOG4105DFD	Na H antiporter
MCR_1014	ENOG4105F04	LysR family Transcriptional regulator
MCR_1015	ENOG4105EXG	Transcriptional regulator
MCR_1017	ENOG4107QMP	dna polymerase iii subunits gamma and tau
MCR_1018	ENOG4105CRK	lysyL-tRNA synthetase
MCR_1020	ENOG4105CGK	Exodeoxyribonuclease III
MCR_1021	ENOG4107YD3	Thioesterase
MCR_1022	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
MCR_1027	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
MCR_1028	ENOG4105D2N	Aldolase
MCR_1030	ENOG4105BZA	Phosphoglycerate kinase
MCR_1031	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
MCR_1032	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
MCR_1033	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
MCR_1035	ENOG4105CDU	Replicative dna helicase
MCR_1036	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
MCR_1039	ENOG4108YRX	Iron-storage protein
MCR_1041	ENOG4105EJQ	L-serine dehydratase
MCR_1044	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
MCR_1045	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
MCR_1047	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
MCR_1049	ENOG4105C59	p-type ATPase
MCR_1050	ENOG4107QNR	UPF0135 protein
MCR_1051	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
MCR_1052	ENOG4105C34	Pseudouridine synthase
MCR_1053	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MCR_1054	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
MCR_1057	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
MCR_1061	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
MCR_1063	ENOG4105CN1	protease
MCR_1064	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
MCR_1066	ENOG4108IG5	Transcriptional regulator
MCR_1067	ENOG4105C7N	Xanthine uracil vitamin C permease
MCR_1068	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MCR_1069	ENOG4105CPK	Glycosyl transferase (Group 1
MCR_1070	ENOG4108JJ8	(ABC) transporter
MCR_1071	ENOG4108JJ9	ABC, transporter
MCR_1073	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
MCR_1077	ENOG4105DJV	ribulose-phosphate 3-epimerase
MCR_1078	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
MCR_1080	ENOG4105EUJ	GTP cyclohydrolase i
MCR_1082	ENOG4107RZC	phospholipase d
MCR_1084	ENOG4105CSH	Transporter
MCR_1087	ENOG4105DWU	Membrane
MCR_1088	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
MCR_1090	ENOG4105C5F	glutamine synthetase
MCR_1093	ENOG4106WTF	Glycosyl transferase, family 2
MCR_1094	ENOG4107J0A	lipopolysaccharide biosynthetic process
MCR_1099	ENOG4105VEQ	Cold shock protein
MCR_1100	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
MCR_1101	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
MCR_1102	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
MCR_1105	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
MCR_1106	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
MCR_1107	ENOG4108VXD	carboxy-peptidase
MCR_1109	ENOG4105FFC	UPF0187 protein
MCR_1110	ENOG4108S0S	Nucleotidyl transferase
MCR_1111	ENOG4105EHM	Aminoglycoside phosphotransferase
MCR_1113	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
MCR_1115	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
MCR_1116	ENOG4108K5P	(LipO)protein
MCR_1118	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
MCR_1119	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
MCR_1120	ENOG4108WWS	isoprenylcysteine carboxyl methyltransferase
MCR_1126	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
MCR_1127	ENOG4105E0X	reductase
MCR_1128	ENOG4105CHM	Aminotransferase
MCR_1130	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
MCR_1132	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
MCR_1133	ENOG4108RXX	maleylacetoacetate isomerase
MCR_1137	ENOG4105CM2	brancheD-chain amino acid aminotransferase
MCR_1139	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
MCR_1144	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
MCR_1146	ENOG4105D06	uba thif-type nad fad binding protein
MCR_1147	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
MCR_1148	ENOG4105EYM	Major Facilitator superfamily
MCR_1149	ENOG4107R11	Transcriptional regulator
MCR_1150	ENOG4105C8P	)-transporter
MCR_1153	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
MCR_1154	ENOG4105F0N	pyrophosphate phospho-hydrolase
MCR_1159	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
MCR_1162	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
MCR_1164	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
MCR_1165	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
MCR_1166	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
MCR_1168	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
MCR_1170	ENOG4105CUT	histidyl-tRNA synthetase
MCR_1172	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
MCR_1174	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
MCR_1175	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
MCR_1176	ENOG4105EZE	Cupin 4 family protein
MCR_1178	ENOG4105C0B	DNA polymerase III (alpha subunit)
MCR_1180	ENOG4105D7W	serine acetyltransferase
MCR_1181	ENOG4108R3E	Dna-3-methyladenine glycosylase i
MCR_1182	ENOG4105D64	Mechanosensitive ion channel
MCR_1184	ENOG4105ERU	peptidase
MCR_1185	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
MCR_1187	ENOG4105C9M	aspartyl-trna synthetase
MCR_1194	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
MCR_1195	ENOG4105C8Y	Acetylornithine aminotransferase
MCR_1196	ENOG4105DWK	Membrane
MCR_1197	ENOG4107XM3	UPF0442 protein
MCR_1200	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
MCR_1201	ENOG4105J0Q	Transcriptional regulator
MCR_1208	ENOG4107XKF	NMT1 THI5 Like Domain Protein
MCR_1209	ENOG4105Y36	Binding-protein-dependent transport systems, inner membrane component
MCR_1217	ENOG4105C0H	protease
MCR_1218	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
MCR_1219	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
MCR_1220	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MCR_1228	ENOG4105CFU	surface antigen
MCR_1229	ENOG4108J8Q	Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity)
MCR_1233	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
MCR_1235	ENOG4105KWW	Biogenesis protein
MCR_1236	ENOG4107QX9	Thiol disulfide interChange protein
MCR_1237	ENOG4105DA4	cytochrome c-type biogenesis protein
MCR_1240	ENOG4106H78	methyltransferase
MCR_1241	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
MCR_1245	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
MCR_1249	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
MCR_1250	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
MCR_1251	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
MCR_1253	ENOG4105DHP	deoxycytidine triphosphate deaminase
MCR_1257	ENOG41067MG	lrgb family
MCR_1258	ENOG4105VAW	lrga family
MCR_1259	ENOG4105D0A	hydroxylase
MCR_1261	ENOG4105D94	Major Facilitator Superfamily
MCR_1262	ENOG4105C4R	Atp-dependent dna helicase
MCR_1264	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
MCR_1265	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
MCR_1267	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
MCR_1268	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
MCR_1269	ENOG4105CAS	nag kinase
MCR_1271	ENOG4105EYW	Ion transport protein
MCR_1272	ENOG4108YYH	Nadph-dependent fmn reductase
MCR_1274	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
MCR_1275	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
MCR_1276	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
MCR_1279	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
MCR_1281	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
MCR_1283	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MCR_1287	ENOG4107QN1	sodium solute
MCR_1290	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
MCR_1291	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
MCR_1294	ENOG4105KUZ	arsenate reductase
MCR_1295	ENOG4105C8T	Leucyl-tRNA synthetase
MCR_1303	ENOG4105DIB	Oligopeptide-binding protein
MCR_1305	ENOG4105C3U	ABC transporter
MCR_1306	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
MCR_1307	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
MCR_1309	ENOG4105WPN	DNA integration recombination invertion protein
MCR_1311	ENOG4105UGU	tonB-dependent Receptor
MCR_1313	ENOG4108E8C	) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
MCR_1314	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
MCR_1315	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
MCR_1316	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
MCR_1317	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
MCR_1319	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
MCR_1320	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
MCR_1323	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
MCR_1326	ENOG4105C58	cytochrome c oxidase accessory protein ccog
MCR_1329	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
MCR_1333	ENOG4108VPT	UPF0234 protein
MCR_1335	ENOG4105C2I	pirin domain protein
MCR_1337	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
MCR_1339	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
MCR_1340	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
MCR_1341	ENOG41072GX	Peptidase M22 Glycoprotease
MCR_1342	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MCR_1345	ENOG4107RH8	nuclease SbcCD subunit D
MCR_1346	ENOG4105EYH	Exonuclease
MCR_1350	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
MCR_1353	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
MCR_1354	ENOG4108UJD	30S ribosomal protein S9
MCR_1355	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
MCR_1356	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
MCR_1357	ENOG4105EIX	cytochrome c1
MCR_1358	ENOG4107MKT	Stringent starvation protein a
MCR_1359	ENOG4105KB2	stringent starvation protein b
MCR_1362	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
MCR_1363	ENOG4108JJB	ABC transporter
MCR_1364	ENOG4105C7J	ABC transporter, permease
MCR_1369	ENOG4106371	Methyltransferase
MCR_1371	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
MCR_1375	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
MCR_1376	ENOG4105CD8	aminopeptidase N
MCR_1377	ENOG4105KCK	Peptidoglycan-associated lipoprotein
MCR_1384	ENOG4105MJ2	Competence protein
MCR_1385	ENOG4105HDD	phospholipase
MCR_1387	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
MCR_1388	ENOG4105CEY	Amp-dependent synthetase and ligase
MCR_1389	ENOG4105CEY	Amp-dependent synthetase and ligase
MCR_1391	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
MCR_1392	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
MCR_1394	ENOG4105VDB	UPF0125 protein
MCR_1397	ENOG4106RE7	Cytochrome
MCR_1400	ENOG4105C8N	cysteinyl-tRNA synthetase
MCR_1401	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
MCR_1402	ENOG4105D8T	Acyltransferase
MCR_1403	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
MCR_1404	ENOG4105K8Z	Phage shock protein
MCR_1409	ENOG4105ECY	inositol monophosphatase
MCR_1411	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
MCR_1415	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
MCR_1422	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
MCR_1424	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
MCR_1425	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
MCR_1426	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
MCR_1429	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
MCR_1430	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
MCR_1431	ENOG4105E3A	(ABC) transporter
MCR_1432	ENOG4105DA5	(ABC) transporter
MCR_1434	ENOG4107XDR	Lactoylglutathione lyase
MCR_1437	ENOG4105D49	3-dehydroquinate synthase
MCR_1438	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
MCR_1439	ENOG4105E4G	Type IV pilus
MCR_1444	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
MCR_1445	ENOG4107SC1	transglycosylase
MCR_1451	ENOG4105C22	threonyL-tRNA synthetase
MCR_1455	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
MCR_1457	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
MCR_1458	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
MCR_1459	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
MCR_1460	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
MCR_1461	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
MCR_1462	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
MCR_1463	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
MCR_1464	ENOG4105CH6	catalase
MCR_1465	ENOG4105CFC	Transporter
MCR_1466	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
MCR_1470	ENOG4108YZY	peptidylprolyl cis-trans isomerase
MCR_1472	ENOG4108R99	pseudouridine synthase
MCR_1474	ENOG4108ZG0	Ompa motb domain protein
MCR_1476	ENOG4105E39	Enoyl-CoA hydratase
MCR_1477	ENOG4105D1Q	UPF0246 protein
MCR_1478	ENOG4105YK5	50S ribosomal protein L36
MCR_1480	ENOG4108DNC	Involved in acetate metabolism (By similarity)
MCR_1481	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
MCR_1484	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
MCR_1485	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
MCR_1487	ENOG4105E2Q	3-(3-hydroxy-phenyl)propionate hydroxylase
MCR_1489	ENOG4105CJ2	(LipO)protein
MCR_1490	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
MCR_1491	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
MCR_1492	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
MCR_1493	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
MCR_1494	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
MCR_1497	ENOG4105CS1	NAD(P)H quinone oxidoreductase
MCR_1498	ENOG4107S2Z	UPF0761 membrane protein
MCR_1503	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
MCR_1519	ENOG4105DFP	Integrase
MCR_1523	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
MCR_1524	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
MCR_1525	ENOG4107S76	domain protein
MCR_1526	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
MCR_1527	ENOG4105C0P	Mg chelatase subunit ChlI
MCR_1528	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
MCR_1529	ENOG4105C5I	Dehydrogenase
MCR_1531	ENOG4105CTB	Polyprenyl synthetase
MCR_1532	ENOG4105CEN	a g-specific adenine glycosylase
MCR_1536	ENOG4108YZA	Nitrogen regulatory protein pii
MCR_1537	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
MCR_1538	ENOG4105CNI	cell division protein FtsW
MCR_1541	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
MCR_1542	ENOG4105VEQ	Cold shock protein
MCR_1546	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
MCR_1547	ENOG4108ZP8	Acetolactate synthase small subunit
MCR_1548	ENOG4105C7K	acetolactate synthase
MCR_1551	ENOG4109066	lysm domain bon superfamily protein
MCR_1553	ENOG4105CHR	reductase
MCR_1554	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
MCR_1558	ENOG4108BPE	-transporting atpase
MCR_1559	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
MCR_1560	ENOG4108ZT0	50S ribosomal protein l17
MCR_1561	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
MCR_1562	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
MCR_1563	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
MCR_1565	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
MCR_1566	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
MCR_1567	ENOG4105VPB	50S ribosomal protein L30
MCR_1569	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
MCR_1570	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
MCR_1571	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
MCR_1572	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
MCR_1573	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MCR_1574	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
MCR_1575	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
MCR_1576	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
MCR_1578	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
MCR_1579	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
MCR_1580	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
MCR_1581	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
MCR_1582	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MCR_1583	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
MCR_1584	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
MCR_1585	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
MCR_1586	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
MCR_1587	ENOG4105C03	ribonuclease
MCR_1588	ENOG4108Z03	MAF-like protein
MCR_1590	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
MCR_1591	ENOG4108J4B	Beta-lactamase
MCR_1592	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
MCR_1595	ENOG4108ZG0	Ompa motb domain protein
MCR_1596	ENOG4106HNH	Acyl-transferase
MCR_1598	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
MCR_1599	ENOG4107QMS	site-determining protein
MCR_1601	ENOG4105VCC	30S ribosomal protein S21
MCR_1602	ENOG4105CK7	Sodium proline symporter
MCR_1603	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
MCR_1604	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
MCR_1605	ENOG4105D4P	Coproporphyrinogen iii oxidase
MCR_1608	ENOG4105DWF	phosphomethylpyrimidine kinase
MCR_1610	ENOG4105II7	pyrroline-5-carboxylate reductase
MCR_1615	ENOG4105C9X	ppx gppa phosphatase
MCR_1616	ENOG4105EI2	Pseudouridine synthase
MCR_1619	ENOG4107QQB	Ribonuclease E
MCR_1621	ENOG4105C82	Malate synthase
MCR_1622	ENOG4107RET	Isocitrate lyase
MCR_1624	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
MCR_1626	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
MCR_1637	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
MCR_1639	ENOG4105DFP	Integrase
MCR_1640	ENOG4105DFP	Integrase
MCR_1642	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
MCR_1646	ENOG4107VZS	Nicotinamide-nucleotide adenylyltransferase
MCR_1649	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
MCR_1651	ENOG4105CBX	hi0933 family
MCR_1655	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
MCR_1658	ENOG4107QN2	dihydrolipoyl dehydrogenase
MCR_1660	ENOG4105CHR	reductase
MCR_1663	ENOG4105VFE	sira family
MCR_1665	ENOG4108NIW	Leucine export protein LeuE
MCR_1666	ENOG4108V1T	peptidylprolyl cis-trans isomerase
MCR_1667	ENOG4105C5H	ABC transporter
MCR_1677	ENOG4105KZX	Pterin carbinolamine dehydratase
MCR_1678	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
MCR_1679	ENOG4105DHI	Methyltransferase
MCR_1681	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
MCR_1683	ENOG4105C2M	dna polymerase I
MCR_1685	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
MCR_1689	ENOG4108JEH	abc transporter atp-binding protein
MCR_1690	ENOG4106PMH	Extracellular solute-binding protein family 3
MCR_1691	ENOG4106TNF	Periplasmic binding protein
MCR_1696	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
MCR_1698	ENOG4108WHA	ompa motb domain protein
MCR_1699	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
MCR_1700	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
MCR_1701	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
MCR_1702	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
MCR_1703	ENOG4105C3F	Signal peptidase i
MCR_1704	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
MCR_1705	ENOG4105WPN	DNA integration recombination invertion protein
MCR_1709	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
MCR_1712	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
MCR_1715	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
MCR_1720	ENOG4105DEN	Luciferase family
MCR_1722	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
MCR_1728	ENOG4105C9X	ppx gppa phosphatase
MCR_1729	ENOG4105BZU	Histidine kinase
MCR_1730	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
MCR_1731	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
MCR_1732	ENOG4105E2Z	phosphate ABC transporter (Permease
MCR_1733	ENOG4105C8U	phosphate abc transporter
MCR_1734	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
MCR_1735	ENOG4105ERG	peptidase m48, ste24p
MCR_1736	ENOG4107PSF	BolA-like protein
MCR_1737	ENOG4105CHH	sulfate transporter
MCR_1739	ENOG4105D3G	Pseudouridine synthase
MCR_1741	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
MCR_1744	ENOG4107GFK	fumarate
MCR_1745	ENOG4105CIH	Imidazole acetol-phosphate transaminase
MCR_1746	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
MCR_1747	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
MCR_1748	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
MCR_1754	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
MCR_1759	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
MCR_1760	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
MCR_1762	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
MCR_1763	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
MCR_1764	ENOG4105T2N	Domain of unknown function (DUF2382)
MCR_1768	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
MCR_1769	ENOG4105CHV	Transcription elongation factor NusA
MCR_1770	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
MCR_1771	ENOG4107EJC	Preprotein translocase subunit SecG
MCR_1773	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
MCR_1774	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
MCR_1775	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
MCR_1776	ENOG4105CJN	penicillin-binding protein
MCR_1778	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
MCR_1779	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
MCR_1782	ENOG4105E7A	Glutamine amidotransferase
MCR_1783	ENOG4105CUV	Homoserine Kinase
MCR_1784	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
MCR_1786	ENOG4107YIM	Involved in the transcription termination process (By similarity)
MCR_1787	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
MCR_1790	ENOG4108ZAI	phosphatidylglycerophosphatase a
MCR_1797	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
MCR_1799	ENOG4105CMR	udp-glucose 4-epimerase
MCR_1807	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
MCR_1808	ENOG4107QP8	phosphohexose isomerase
MCR_1809	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
MCR_1810	ENOG4105E55	glycerol-3-phosphate acyltransferase
MCR_1811	ENOG4105C29	acyl-CoA thioesterase
MCR_1813	ENOG4107QS8	(LipO)protein
MCR_1814	ENOG4108K5H	permease YjgP YjgQ family protein
MCR_1815	ENOG4108M8S	permease YjgP YjgQ family protein
MCR_1817	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
MCR_1818	ENOG4105CGF	Aromatic amino acid aminotransferase
MCR_1819	ENOG4105F04	LysR family Transcriptional regulator
MCR_1821	ENOG4105C37	(CBS) domain
MCR_1822	ENOG4105UBK	short-chain dehydrogenase reductase
MCR_1823	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
MCR_1825	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
MCR_1832	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
MCR_1833	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
MCR_1834	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
MCR_1835	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MCR_1836	ENOG4105DJ0	Poly(A) Polymerase
MCR_1837	ENOG4105KQC	Competence protein
MCR_1838	ENOG4105DXN	mazG family
MCR_1839	ENOG4105C6T	cysteine synthase
MCR_1846	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
MCR_1847	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
MCR_1848	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
MCR_1850	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
MCR_1851	ENOG4108UJU	UPF0301 protein
MCR_1852	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
MCR_1853	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
MCR_1855	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
MCR_1856	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
MCR_1857	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
MCR_1868	ENOG4105DIK	(ABC) transporter
MCR_1869	ENOG4105CC5	ABC transporter
MCR_1870	ENOG4105CC5	ABC transporter
MCR_1873	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
MCR_1874	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
MCR_1881	ENOG4105C8Y	Acetylornithine aminotransferase
MCR_1884	ENOG4105C7F	AcnD-accessory protein PrpF
MCR_1887	ENOG4107Y49	methyltransferase
MCR_1890	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
MCR_1893	ENOG4105C79	DNA protecting protein DprA
MCR_1896	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
MCR_1899	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
MCR_1900	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
MCR_1901	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
MCR_1902	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
MCR_1903	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
MCR_1904	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)