locus-tag	class	description
MCR_0001	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MCR_0003	COG0592	DNA-directed DNA polymerase activity
MCR_0005	COG0187	DNA topoisomerase II activity
MCR_0006	COG0519	Catalyzes the synthesis of GMP from XMP
MCR_0006	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MCR_0012	COG3977	Valine--pyruvate aminotransferase
MCR_0013	COG0251	oxidation-reduction process
MCR_0016	COG1132	(ABC) transporter
MCR_0017	COG0165	Argininosuccinate lyase
MCR_0018	COG0181	hydroxymethylbilane synthase activity
MCR_0020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MCR_0022	COG0443	Heat shock 70 kDa protein
MCR_0031	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MCR_0034	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MCR_0035	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MCR_0036	COG2918	glutathione biosynthetic process
MCR_0037	COG0316	Belongs to the HesB IscA family
MCR_0038	COG1116	anion transmembrane transporter activity
MCR_0038	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCR_0039	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCR_0040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCR_0040	COG1116	anion transmembrane transporter activity
MCR_0044	COG0488	(ABC) transporter
MCR_0045	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MCR_0046	COG0429	hydrolase of the alpha beta-hydrolase fold
MCR_0047	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MCR_0048	COG0626	cystathionine gamma-synthase activity
MCR_0049	COG0385	Bile acid
MCR_0050	COG0484	heat shock protein binding
MCR_0055	COG1739	Uncharacterized protein family UPF0029
MCR_0058	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MCR_0059	COG0523	cobalamin synthesis protein
MCR_0060	COG0745	RESPONSE REGULATOR receiver
MCR_0066	COG2009	succinate dehydrogenase
MCR_0067	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MCR_0068	COG1053	succinate dehydrogenase
MCR_0081	COG1505	serine-type exopeptidase activity
MCR_0084	COG0339	signal peptide processing
MCR_0085	COG3568	Endonuclease Exonuclease Phosphatase
MCR_0087	COG0544	peptidyl-prolyl cis-trans isomerase activity
MCR_0088	COG0740	serine-type endopeptidase activity
MCR_0089	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MCR_0090	COG0484	heat shock protein binding
MCR_0091	COG1024	Enoyl-CoA hydratase
MCR_0091	COG1250	3-hydroxyacyl-CoA dehydrogenase
MCR_0092	COG0183	Belongs to the thiolase family
MCR_0097	COG2895	sulfate adenylyltransferase (ATP) activity
MCR_0098	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MCR_0106	COG0237	dephospho-CoA kinase activity
MCR_0107	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MCR_0109	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MCR_0110	COG2814	Major facilitator Superfamily
MCR_0114	COG0786	glutamate:sodium symporter activity
MCR_0115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MCR_0115	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MCR_0119	COG2822	iron ion transport
MCR_0120	COG2837	iron assimilation
MCR_0121	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MCR_0124	COG0069	glutamate synthase activity
MCR_0126	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MCR_0127	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MCR_0128	COG0140	phosphoribosyl-ATP diphosphatase activity
MCR_0128	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MCR_0130	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MCR_0133	COG1959	2 iron, 2 sulfur cluster binding
MCR_0140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MCR_0141	COG0072	phenylalanine-tRNA ligase activity
MCR_0141	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MCR_0142	COG0776	regulation of translation
MCR_0143	COG0254	rRNA binding
MCR_0144	COG3115	cell septum assembly
MCR_0145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MCR_0146	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MCR_0149	COG0513	Belongs to the DEAD box helicase family
MCR_0150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MCR_0156	COG5002	protein histidine kinase activity
MCR_0156	COG2205	protein histidine kinase activity
MCR_0156	COG0784	Response regulator, receiver
MCR_0158	COG0688	phosphatidylethanolamine metabolic process
MCR_0159	COG2832	Protein of unknown function (DUF454)
MCR_0162	COG4106	trans-aconitate 2-methyltransferase activity
MCR_0164	COG1490	D-aminoacyl-tRNA deacylase activity
MCR_0166	COG0494	nUDIX hydrolase
MCR_0170	COG0629	single-stranded DNA binding
MCR_0171	COG0754	glutathionylspermidine amidase activity
MCR_0174	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MCR_0175	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MCR_0176	COG1464	Belongs to the NlpA lipoprotein family
MCR_0178	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MCR_0180	COG0745	RESPONSE REGULATOR receiver
MCR_0184	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MCR_0185	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MCR_0188	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MCR_0191	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
MCR_0191	COG0644	oxidoreductase
MCR_0194	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MCR_0196	COG2951	lytic endotransglycosylase activity
MCR_0197	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCR_0198	COG4106	trans-aconitate 2-methyltransferase activity
MCR_0199	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MCR_0200	COG2354	Protein conserved in bacteria
MCR_0206	COG2195	Cleaves the N-terminal amino acid of tripeptides
MCR_0207	COG0412	Dienelactone hydrolase
MCR_0208	COG2983	Belongs to the UPF0260 family
MCR_0209	COG4535	Mg2 and Co2 transporter CorC
MCR_0211	COG2824	Alkylphosphonate utilization operon protein PhnA
MCR_0212	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MCR_0213	COG0653	protein targeting
MCR_0226	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MCR_0227	COG0049	tRNA binding
MCR_0229	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MCR_0230	COG0492	ferredoxin-NADP+ reductase activity
MCR_0231	COG1960	acyl-CoA dehydrogenase activity
MCR_0233	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MCR_0236	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MCR_0237	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MCR_0238	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MCR_0240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MCR_0241	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MCR_0247	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCR_0250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MCR_0253	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MCR_0254	COG0081	regulation of translation
MCR_0256	COG0222	ribosome binding
MCR_0257	COG0085	RNA polymerase activity
MCR_0258	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MCR_0259	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MCR_0260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MCR_0264	COG0793	Belongs to the peptidase S41A family
MCR_0265	COG5487	UPF0391 membrane protein
MCR_0266	COG0730	response to heat
MCR_0268	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MCR_0270	COG1765	OsmC-like protein
MCR_0273	COG0494	nUDIX hydrolase
MCR_0275	COG1196	nuclear chromosome segregation
MCR_0276	COG0052	Belongs to the universal ribosomal protein uS2 family
MCR_0277	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MCR_0279	COG0189	ligase activity
MCR_0280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MCR_0282	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MCR_0283	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MCR_0286	COG0583	DNA-binding transcription factor activity
MCR_0287	COG0450	alkyl hydroperoxide reductase
MCR_0291	COG3634	alkyl hydroperoxide reductase activity
MCR_0292	COG2975	iron-sulfur cluster assembly
MCR_0296	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MCR_0300	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MCR_0301	COG1183	phosphatidylcholine synthase activity
MCR_0302	COG0561	phosphatase activity
MCR_0304	COG0561	phosphatase activity
MCR_0305	COG0586	Pfam SNARE associated Golgi protein
MCR_0306	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MCR_0307	COG0849	cell division
MCR_0308	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MCR_0310	COG2137	regulation of response to DNA damage stimulus
MCR_0311	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MCR_0314	COG0277	FAD linked oxidase domain protein
MCR_0319	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MCR_0320	COG2171	N-acyltransferase activity
MCR_0323	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MCR_0325	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MCR_0328	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MCR_0330	COG0583	DNA-binding transcription factor activity
MCR_0331	COG0586	Pfam SNARE associated Golgi protein
MCR_0332	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MCR_0333	COG0735	belongs to the Fur family
MCR_0342	COG0196	riboflavin kinase activity
MCR_0343	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MCR_0346	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MCR_0347	COG2837	iron assimilation
MCR_0350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MCR_0351	COG1758	RNA polymerase activity
MCR_0352	COG0194	GDP metabolic process
MCR_0354	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MCR_0356	COG2860	membrane
MCR_0358	COG0602	queuosine metabolic process
MCR_0359	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MCR_0362	COG0076	glutamate decarboxylase activity
MCR_0363	COG0322	excinuclease ABC activity
MCR_0365	COG0546	phosphoglycolate phosphatase activity
MCR_0367	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MCR_0368	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MCR_0370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MCR_0371	COG1121	(ABC) transporter
MCR_0372	COG0735	belongs to the Fur family
MCR_0376	COG0356	it plays a direct role in the translocation of protons across the membrane
MCR_0378	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MCR_0379	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MCR_0380	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MCR_0381	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MCR_0383	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MCR_0384	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MCR_0385	COG0745	RESPONSE REGULATOR receiver
MCR_0386	COG2205	protein histidine kinase activity
MCR_0388	COG0228	four-way junction DNA binding
MCR_0389	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MCR_0390	COG0336	Belongs to the RNA methyltransferase TrmD family
MCR_0391	COG0335	large ribosomal subunit rRNA binding
MCR_0395	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MCR_0396	COG2986	histidine ammonia-lyase
MCR_0397	COG0010	Belongs to the arginase family
MCR_0398	COG1228	amidohydrolase
MCR_0402	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MCR_0403	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MCR_0404	COG0540	Belongs to the ATCase OTCase family
MCR_0407	COG2301	Belongs to the HpcH HpaI aldolase family
MCR_0408	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MCR_0409	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MCR_0410	COG0628	permease
MCR_0412	COG1671	Belongs to the UPF0178 family
MCR_0414	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MCR_0420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MCR_0426	COG0393	Putative heavy-metal-binding
MCR_0430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MCR_0431	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MCR_0435	COG1534	Rna-binding protein
MCR_0436	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MCR_0437	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCR_0440	COG0326	Molecular chaperone. Has ATPase activity
MCR_0444	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MCR_0445	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MCR_0448	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MCR_0452	COG0531	amino acid
MCR_0454	COG0617	tRNA 3'-terminal CCA addition
MCR_0458	COG2255	four-way junction helicase activity
MCR_0461	COG1028	Short-chain dehydrogenase reductase Sdr
MCR_0466	COG0129	dihydroxy-acid dehydratase activity
MCR_0469	COG0628	permease
MCR_0471	COG0537	adenosine 5'-monophosphoramidase activity
MCR_0473	COG1720	tRNA m6t6A37 methyltransferase activity
MCR_0474	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCR_0476	COG1538	Outer membrane efflux protein
MCR_0478	COG0277	FAD linked oxidase domain protein
MCR_0483	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MCR_0486	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MCR_0489	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MCR_0492	COG1629	transport
MCR_0495	COG2264	protein methyltransferase activity
MCR_0496	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MCR_0499	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MCR_0500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MCR_0504	COG2233	PERMEase
MCR_0505	COG1115	amino acid carrier protein
MCR_0506	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MCR_0512	COG0728	peptidoglycan biosynthetic process
MCR_0513	COG3023	N-Acetylmuramoyl-L-alanine amidase
MCR_0516	COG0471	metal ion transport
MCR_0517	COG0525	valine-tRNA ligase activity
MCR_0522	COG0123	including yeast histone deacetylase and acetoin utilization protein
MCR_0525	COG4133	protoheme IX ABC transporter activity
MCR_0527	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MCR_0530	COG2363	Small membrane protein
MCR_0535	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MCR_0537	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MCR_0539	COG0528	UMP kinase activity
MCR_0540	COG0233	cytoplasmic translational termination
MCR_0541	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MCR_0542	COG0575	Belongs to the CDS family
MCR_0543	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MCR_0547	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MCR_0548	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MCR_0549	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MCR_0550	COG0733	neurotransmitter:sodium symporter activity
MCR_0553	COG1294	oxidase, subunit
MCR_0558	COG1115	amino acid carrier protein
MCR_0568	COG0778	Nitroreductase
MCR_0569	COG1902	pentaerythritol trinitrate reductase activity
MCR_0571	COG0583	DNA-binding transcription factor activity
MCR_0572	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MCR_0573	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MCR_0576	COG0628	permease
MCR_0577	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MCR_0578	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MCR_0580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MCR_0581	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MCR_0583	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MCR_0584	COG0527	aspartate kinase activity
MCR_0587	COG3104	oligopeptide transport
MCR_0591	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MCR_0596	COG0482	sulfurtransferase activity
MCR_0597	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MCR_0598	COG1335	isochorismatase
MCR_0600	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MCR_0605	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MCR_0606	COG0316	Belongs to the HesB IscA family
MCR_0607	COG0822	iron-sulfur transferase activity
MCR_0609	COG1959	2 iron, 2 sulfur cluster binding
MCR_0614	COG0138	bifunctional purine biosynthesis protein purh
MCR_0617	COG5295	Hep Hag repeat protein
MCR_0617	COG5295	Hep Hag repeat protein
MCR_0621	COG2264	protein methyltransferase activity
MCR_0625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MCR_0626	COG2217	Heavy metal translocating P-type atpase
MCR_0629	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MCR_0632	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MCR_0637	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MCR_0642	COG2321	neutral zinc metallopeptidase
MCR_0650	COG4591	ABC-type transport system involved in lipoprotein release permease component
MCR_0651	COG1136	(ABC) transporter
MCR_0654	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MCR_0656	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MCR_0658	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MCR_0661	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MCR_0662	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MCR_0664	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MCR_0666	COG3753	Protein conserved in bacteria
MCR_0667	COG0560	Phosphoserine phosphatase
MCR_0681	COG0739	heme binding
MCR_0681	COG0741	lytic transglycosylase activity
MCR_0681	COG1196	nuclear chromosome segregation
MCR_0682	COG0501	Belongs to the peptidase M48B family
MCR_0683	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MCR_0684	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MCR_0685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MCR_0687	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MCR_0695	COG0668	transmembrane transport
MCR_0696	COG0084	hydrolase, TatD family'
MCR_0697	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MCR_0700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MCR_0701	COG0259	pyridoxamine-phosphate oxidase activity
MCR_0704	COG2608	mercury ion transmembrane transporter activity
MCR_0705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCR_0708	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCR_0709	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCR_0709	COG0649	NAD binding
MCR_0713	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MCR_0714	COG1034	ATP synthesis coupled electron transport
MCR_0715	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MCR_0716	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MCR_0717	COG0839	Belongs to the complex I subunit 6 family
MCR_0718	COG0713	ATP synthesis coupled electron transport
MCR_0721	COG1007	ATP synthesis coupled electron transport
MCR_0722	COG0678	peroxiredoxin activity
MCR_0722	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MCR_0723	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MCR_0725	COG0018	arginyl-trna synthetase
MCR_0726	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MCR_0727	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MCR_0728	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MCR_0729	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MCR_0732	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MCR_0733	COG0217	transcriptional regulatory protein
MCR_0734	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MCR_0737	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MCR_0738	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MCR_0741	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MCR_0741	COG0301	tRNA thio-modification
MCR_0745	COG0288	reversible hydration of carbon dioxide
MCR_0746	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MCR_0747	COG1140	nitrate reductase beta subunit
MCR_0748	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MCR_0749	COG2181	nitrate reductase activity
MCR_0751	COG0303	'Molybdopterin
MCR_0753	COG4149	molybdate abc transporter
MCR_0754	COG0725	ABC transporter, periplasmic molybdate-binding protein
MCR_0756	COG0314	molybdopterin synthase activity
MCR_0757	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MCR_0758	COG0315	cyclic pyranopterin monophosphate synthase activity
MCR_0760	COG0521	Mo-molybdopterin cofactor biosynthetic process
MCR_0761	COG2258	MOSC domain
MCR_0762	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MCR_0763	COG2197	response regulator
MCR_0764	COG3850	Histidine kinase
MCR_0766	COG2223	nitrite transmembrane transporter activity
MCR_0787	COG1012	belongs to the aldehyde dehydrogenase family
MCR_0790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MCR_0795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MCR_0802	COG2056	Na+-H+ antiporter family
MCR_0803	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MCR_0803	COG0475	glutathione-regulated potassium exporter activity
MCR_0804	COG0598	Magnesium transport protein CorA
MCR_0805	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MCR_0807	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MCR_0812	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MCR_0813	COG1067	ATP-dependent peptidase activity
MCR_0814	COG0357	Ribosomal RNA small subunit methyltransferase G
MCR_0815	COG1192	Involved in chromosome partitioning
MCR_0817	COG1475	DNA binding
MCR_0818	COG1663	tetraacyldisaccharide 4'-kinase activity
MCR_0819	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MCR_0822	COG1304	FMN binding
MCR_0823	COG1620	l-lactate permease
MCR_0825	COG0708	Exodeoxyribonuclease III
MCR_0826	COG1309	transcriptional regulator
MCR_0831	COG0105	UTP biosynthetic process
MCR_0834	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MCR_0836	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MCR_0838	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MCR_0839	COG1702	phosphate starvation-inducible protein PhoH
MCR_0841	COG0511	ligase activity, forming carbon-carbon bonds
MCR_0843	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MCR_0844	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MCR_0845	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MCR_0846	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MCR_0848	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MCR_0849	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MCR_0851	COG0134	indole-3-glycerol-phosphate synthase activity
MCR_0852	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MCR_0855	COG1560	Kdo2-lipid A biosynthetic process
MCR_0857	COG2900	Belongs to the SlyX family
MCR_0861	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MCR_0866	COG0590	tRNA wobble adenosine to inosine editing
MCR_0867	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MCR_0869	COG0776	regulation of translation
MCR_0871	COG0284	orotidine-5'-phosphate decarboxylase activity
MCR_0872	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MCR_0873	COG2095	MarC family integral membrane protein
MCR_0874	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MCR_0874	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MCR_0875	COG2350	Protein conserved in bacteria
MCR_0878	COG2816	NAD+ diphosphatase activity
MCR_0880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MCR_0883	COG0151	Belongs to the GarS family
MCR_0884	COG0179	Fumarylacetoacetate (FAA) hydrolase
MCR_0886	COG1773	rubredoxin
MCR_0888	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MCR_0894	COG0625	glutathione transferase activity
MCR_0898	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MCR_0899	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MCR_0902	COG0019	diaminopimelate decarboxylase activity
MCR_0906	COG0802	atpase or kinase
MCR_0907	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MCR_0908	COG1923	regulation of RNA biosynthetic process
MCR_0909	COG0517	IMP dehydrogenase activity
MCR_0909	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MCR_0911	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MCR_0914	COG1137	ATPase activity
MCR_0918	COG0612	Peptidase, M16
MCR_0921	COG0552	protein localization to endoplasmic reticulum
MCR_0923	COG0167	dihydroorotate dehydrogenase activity
MCR_0927	COG0556	nucleotide-excision repair
MCR_0929	COG1074	ATP-dependent DNA helicase activity
MCR_0930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MCR_0931	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MCR_0933	COG1570	exodeoxyribonuclease VII activity
MCR_0934	COG2326	polyphosphate kinase activity
MCR_0957	COG3617	BRO family, N-terminal domain
MCR_0967	COG1598	PFAM Uncharacterised protein family UPF0150
MCR_0974	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MCR_0976	COG1643	Atp-dependent helicase
MCR_0980	COG0823	Involved in the tonB-independent uptake of proteins
MCR_0982	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MCR_0983	COG0352	thiamine-phosphate diphosphorylase activity
MCR_0992	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MCR_0994	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MCR_0995	COG0513	Belongs to the DEAD box helicase family
MCR_0997	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MCR_0998	COG4208	sulfate ABC transporter
MCR_1003	COG0741	lytic transglycosylase activity
MCR_1003	COG1388	LysM domain
MCR_1006	COG1253	flavin adenine dinucleotide binding
MCR_1007	COG1862	Preprotein translocase
MCR_1010	COG1686	Belongs to the peptidase S11 family
MCR_1014	COG0583	DNA-binding transcription factor activity
MCR_1017	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MCR_1018	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MCR_1020	COG0708	Exodeoxyribonuclease III
MCR_1021	COG0824	Thioesterase
MCR_1026	COG0583	DNA-binding transcription factor activity
MCR_1027	COG0632	four-way junction helicase activity
MCR_1028	COG0191	fructose-bisphosphate aldolase activity
MCR_1030	COG0126	phosphoglycerate kinase activity
MCR_1031	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MCR_1032	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MCR_1033	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MCR_1035	COG0305	Participates in initiation and elongation during chromosome replication
MCR_1036	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MCR_1041	COG1760	l-serine dehydratase
MCR_1044	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MCR_1045	COG0542	response to heat
MCR_1047	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MCR_1049	COG2217	Heavy metal translocating P-type atpase
MCR_1050	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MCR_1054	COG0358	DNA primase activity
MCR_1061	COG0268	Binds directly to 16S ribosomal RNA
MCR_1062	COG2197	response regulator
MCR_1063	COG0793	Belongs to the peptidase S41A family
MCR_1064	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MCR_1067	COG2252	PERMEase
MCR_1068	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MCR_1069	COG0438	transferase activity, transferring glycosyl groups
MCR_1070	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MCR_1071	COG4988	ABC transporter
MCR_1073	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MCR_1077	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MCR_1080	COG0302	gtp cyclohydrolase
MCR_1082	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MCR_1084	COG0477	Major facilitator Superfamily
MCR_1087	COG2431	L-lysine efflux transmembrane transporter activity
MCR_1088	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MCR_1093	COG0463	Glycosyl transferase, family 2
MCR_1100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MCR_1101	COG0037	tRNA processing
MCR_1102	COG0116	Belongs to the methyltransferase superfamily
MCR_1102	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MCR_1105	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MCR_1106	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MCR_1107	COG1876	peptidase activity
MCR_1109	COG3781	membrane
MCR_1110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MCR_1111	COG3178	'Phosphotransferase
MCR_1113	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MCR_1115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MCR_1116	COG4942	peptidase
MCR_1118	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MCR_1119	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MCR_1120	COG1755	Isoprenylcysteine carboxyl methyltransferase
MCR_1126	COG0505	Belongs to the CarA family
MCR_1127	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCR_1128	COG0436	Aminotransferase
MCR_1130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MCR_1132	COG1648	precorrin-2 dehydrogenase activity
MCR_1132	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MCR_1133	COG0625	glutathione transferase activity
MCR_1139	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MCR_1143	COG1607	acyl-coa hydrolase
MCR_1144	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MCR_1146	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MCR_1147	COG2890	protein-(glutamine-N5) methyltransferase activity
MCR_1148	COG2211	Major facilitator Superfamily
MCR_1149	COG0583	DNA-binding transcription factor activity
MCR_1150	COG0471	metal ion transport
MCR_1153	COG0321	lipoyl(octanoyl) transferase activity
MCR_1159	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MCR_1162	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MCR_1164	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MCR_1165	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MCR_1166	COG1160	GTP binding
MCR_1168	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MCR_1170	COG0124	histidyl-tRNA synthetase
MCR_1172	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MCR_1174	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MCR_1175	COG2890	protein-(glutamine-N5) methyltransferase activity
MCR_1176	COG2850	peptidyl-arginine hydroxylation
MCR_1178	COG0587	DNA-directed DNA polymerase activity
MCR_1180	COG1045	serine acetyltransferase
MCR_1181	COG2818	Glycosylase
MCR_1182	COG0668	transmembrane transport
MCR_1184	COG0616	signal peptide processing
MCR_1185	COG3263	regulation of cellular component size
MCR_1187	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MCR_1194	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MCR_1195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MCR_1196	COG2966	Psort location CytoplasmicMembrane, score
MCR_1197	COG3610	response to peptide
MCR_1200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MCR_1206	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MCR_1207	COG1116	anion transmembrane transporter activity
MCR_1208	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCR_1209	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCR_1217	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCR_1218	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MCR_1219	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MCR_1220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MCR_1228	COG0729	surface antigen
MCR_1229	COG2814	Major facilitator Superfamily
MCR_1233	COG0563	adenylate kinase activity
MCR_1240	COG0742	ribosomal rna small subunit methyltransferase
MCR_1245	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MCR_1250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MCR_1250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MCR_1251	COG0585	pseudouridine synthase activity
MCR_1253	COG0717	Belongs to the dCTP deaminase family
MCR_1257	COG1346	cytolysis
MCR_1258	COG1380	Effector of murein hydrolase LrgA
MCR_1259	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MCR_1261	COG2814	Major facilitator Superfamily
MCR_1262	COG0210	DNA helicase
MCR_1264	COG1162	GTPase activity
MCR_1265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MCR_1267	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MCR_1268	COG0756	dUTP diphosphatase activity
MCR_1269	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MCR_1271	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCR_1272	COG0431	NADPH-dependent FMN reductase
MCR_1274	COG0359	binds to the 23S rRNA
MCR_1275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MCR_1276	COG0360	Binds together with S18 to 16S ribosomal RNA
MCR_1278	COG3100	YcgL domain-containing protein
MCR_1281	COG0509	glycine decarboxylation via glycine cleavage system
MCR_1283	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MCR_1283	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MCR_1284	COG1966	Carbon starvation protein
MCR_1287	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MCR_1289	COG0489	protein tyrosine kinase activity
MCR_1290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MCR_1291	COG0343	queuine tRNA-ribosyltransferase activity
MCR_1294	COG1393	Belongs to the ArsC family
MCR_1295	COG0495	leucyl-tRNA aminoacylation
MCR_1303	COG4166	transmembrane transport
MCR_1305	COG0444	Belongs to the ABC transporter superfamily
MCR_1306	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MCR_1307	COG0601	transmembrane transport
MCR_1309	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MCR_1313	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MCR_1313	COG0616	signal peptide processing
MCR_1314	COG2333	competence protein COMEC
MCR_1314	COG0658	competence protein
MCR_1315	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MCR_1316	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MCR_1317	COG0148	phosphopyruvate hydratase activity
MCR_1319	COG0504	CTP synthase activity
MCR_1320	COG2010	Cytochrome c
MCR_1323	COG3278	Belongs to the heme-copper respiratory oxidase family
MCR_1326	COG0348	domain, Protein
MCR_1329	COG1376	ErfK ybiS ycfS ynhG family protein
MCR_1333	COG1666	GTP binding
MCR_1335	COG1741	Belongs to the pirin family
MCR_1337	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MCR_1339	COG0742	ribosomal rna small subunit methyltransferase
MCR_1340	COG1968	undecaprenyl-diphosphatase activity
MCR_1341	COG1214	PFAM Peptidase M22, glycoprotease
MCR_1342	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MCR_1345	COG0420	3'-5' exonuclease activity
MCR_1346	COG0419	ATPase involved in DNA repair
MCR_1350	COG0445	tRNA wobble uridine modification
MCR_1353	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MCR_1354	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MCR_1355	COG0723	plastoquinol--plastocyanin reductase activity
MCR_1356	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MCR_1357	COG2857	Cytochrome c1
MCR_1358	COG0625	glutathione transferase activity
MCR_1359	COG2969	positive regulation of protein catabolic process
MCR_1364	COG4120	Belongs to the binding-protein-dependent transport system permease family
MCR_1369	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MCR_1371	COG1696	Membrane protein involved in D-alanine export
MCR_1375	COG1519	Transferase
MCR_1376	COG0308	aminopeptidase N
MCR_1377	COG2885	chlorophyll binding
MCR_1384	COG1040	competence protein
MCR_1387	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MCR_1388	COG0318	PFAM AMP-dependent synthetase and ligase
MCR_1389	COG0318	PFAM AMP-dependent synthetase and ligase
MCR_1391	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MCR_1392	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MCR_1394	COG2914	Belongs to the UPF0125 (RnfH) family
MCR_1400	COG0215	cysteine-tRNA ligase activity
MCR_1401	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MCR_1401	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MCR_1402	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MCR_1403	COG2022	thiamine diphosphate biosynthetic process
MCR_1404	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MCR_1411	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MCR_1415	COG0408	coproporphyrinogen oxidase activity
MCR_1422	COG0285	dihydrofolate synthase activity
MCR_1424	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MCR_1425	COG0159	tryptophan synthase activity
MCR_1426	COG0133	tryptophan synthase activity
MCR_1429	COG0442	prolyl-tRNA aminoacylation
MCR_1430	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MCR_1430	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MCR_1431	COG0842	Transport permease protein
MCR_1432	COG1131	(ABC) transporter
MCR_1437	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MCR_1438	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MCR_1444	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MCR_1445	COG0741	lytic transglycosylase activity
MCR_1451	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MCR_1455	COG0557	exoribonuclease II activity
MCR_1457	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MCR_1458	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MCR_1459	COG1805	sodium ion transport
MCR_1460	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MCR_1461	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MCR_1462	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MCR_1463	COG2871	sodium ion transport
MCR_1464	COG0753	catalase activity
MCR_1465	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MCR_1466	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MCR_1470	COG1047	Peptidyl-prolyl cis-trans
MCR_1472	COG1187	pseudouridine synthase activity
MCR_1474	COG2885	chlorophyll binding
MCR_1476	COG1024	Enoyl-CoA hydratase
MCR_1477	COG3022	response to hydroperoxide
MCR_1478	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MCR_1480	COG0280	phosphate acetyltransferase
MCR_1480	COG0857	belongs to the CobB CobQ family
MCR_1481	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MCR_1484	COG0019	diaminopimelate decarboxylase activity
MCR_1485	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MCR_1487	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MCR_1489	COG1477	protein flavinylation
MCR_1490	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MCR_1491	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MCR_1492	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MCR_1493	COG0459	protein refolding
MCR_1494	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MCR_1498	COG1295	ribonuclease BN
MCR_1503	COG0358	DNA primase activity
MCR_1519	COG0582	viral genome integration into host DNA
MCR_1523	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MCR_1524	COG0024	Methionine aminopeptidase
MCR_1525	COG3453	Protein conserved in bacteria
MCR_1525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCR_1526	COG0446	pyridine nucleotide-disulphide oxidoreductase
MCR_1526	COG1902	pentaerythritol trinitrate reductase activity
MCR_1527	COG0606	chelatase, subunit chli
MCR_1528	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MCR_1529	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MCR_1531	COG0142	geranyltranstransferase activity
MCR_1532	COG1194	a g-specific adenine glycosylase
MCR_1536	COG0347	Belongs to the P(II) protein family
MCR_1537	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MCR_1538	COG0772	Belongs to the SEDS family
MCR_1541	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MCR_1542	COG1278	Cold shock
MCR_1546	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MCR_1547	COG0440	acetolactate synthase activity
MCR_1548	COG0028	Belongs to the TPP enzyme family
MCR_1551	COG1652	LysM domain
MCR_1556	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MCR_1558	COG3101	peptidyl-lysine hydroxylation
MCR_1559	COG0009	L-threonylcarbamoyladenylate synthase
MCR_1560	COG0203	ribosomal protein L17
MCR_1561	COG0202	RNA polymerase activity
MCR_1562	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MCR_1563	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MCR_1566	COG0200	Binds to the 23S rRNA
MCR_1567	COG1841	ribosomal large subunit assembly
MCR_1569	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MCR_1570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MCR_1571	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MCR_1572	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MCR_1573	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MCR_1574	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MCR_1575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MCR_1576	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MCR_1577	COG0255	Belongs to the universal ribosomal protein uL29 family
MCR_1578	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MCR_1579	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MCR_1580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MCR_1581	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MCR_1582	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MCR_1583	COG0089	rRNA binding
MCR_1584	COG0088	Forms part of the polypeptide exit tunnel
MCR_1585	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MCR_1586	COG0051	transcription antitermination factor activity, RNA binding
MCR_1587	COG1530	ribonuclease E activity
MCR_1588	COG0424	maF-like protein
MCR_1589	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MCR_1590	COG0154	amidase activity
MCR_1591	COG2367	Beta-lactamase
MCR_1592	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MCR_1595	COG2885	chlorophyll binding
MCR_1596	COG0204	Acyl-transferase
MCR_1598	COG0850	regulation of cytokinetic process
MCR_1600	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MCR_1601	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MCR_1602	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MCR_1603	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MCR_1604	COG0193	aminoacyl-tRNA hydrolase activity
MCR_1605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MCR_1608	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MCR_1608	COG0351	phosphomethylpyrimidine kinase
MCR_1608	COG0352	thiamine-phosphate diphosphorylase activity
MCR_1610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MCR_1611	COG0037	tRNA processing
MCR_1615	COG0248	Ppx GppA phosphatase
MCR_1616	COG0564	pseudouridine synthase activity
MCR_1619	COG1530	ribonuclease E activity
MCR_1621	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MCR_1624	COG3161	chorismate lyase activity
MCR_1626	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MCR_1639	COG0582	viral genome integration into host DNA
MCR_1640	COG0582	viral genome integration into host DNA
MCR_1642	COG0752	glycyl-tRNA synthetase alpha subunit
MCR_1649	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MCR_1651	COG2081	HI0933 family
MCR_1654	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MCR_1655	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MCR_1657	COG1051	belongs to the nudix hydrolase family
MCR_1657	COG1056	cytidyltransferase-related domain
MCR_1658	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MCR_1660	COG1028	Short-chain dehydrogenase reductase Sdr
MCR_1663	COG0425	Belongs to the sulfur carrier protein TusA family
MCR_1663	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MCR_1667	COG0488	(ABC) transporter
MCR_1677	COG2154	pterin-4-alpha-carbinolamine dehydratase
MCR_1678	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MCR_1679	COG2226	methyltransferase
MCR_1681	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MCR_1683	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MCR_1683	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MCR_1687	COG1674	ftsk spoiiie
MCR_1690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MCR_1691	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MCR_1696	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MCR_1698	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MCR_1698	COG2885	chlorophyll binding
MCR_1699	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MCR_1700	COG1381	Involved in DNA repair and RecF pathway recombination
MCR_1701	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MCR_1702	COG0571	ribonuclease III activity
MCR_1704	COG0481	GTPase activity
MCR_1705	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MCR_1709	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MCR_1712	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MCR_1715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MCR_1720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCR_1722	COG3842	ATPase activity
MCR_1731	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MCR_1732	COG0581	inorganic phosphate transmembrane transporter activity
MCR_1733	COG0573	inorganic phosphate transmembrane transporter activity
MCR_1735	COG4783	chaperone-mediated protein folding
MCR_1736	COG0271	Belongs to the BolA IbaG family
MCR_1737	COG0659	secondary active sulfate transmembrane transporter activity
MCR_1739	COG0564	pseudouridine synthase activity
MCR_1744	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
MCR_1744	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MCR_1745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MCR_1746	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MCR_1747	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MCR_1748	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MCR_1754	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MCR_1759	COG1185	polyribonucleotide nucleotidyltransferase activity
MCR_1760	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MCR_1762	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MCR_1763	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MCR_1764	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
MCR_1768	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MCR_1769	COG0195	Participates in both transcription termination and antitermination
MCR_1769	COG2251	uridine kinase activity
MCR_1770	COG0779	Required for maturation of 30S ribosomal subunits
MCR_1773	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MCR_1774	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MCR_1775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MCR_1778	COG0275	rRNA processing
MCR_1779	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MCR_1782	COG0121	glutamine amidotransferase
MCR_1783	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MCR_1784	COG0107	imidazoleglycerol-phosphate synthase activity
MCR_1786	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MCR_1787	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MCR_1790	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MCR_1797	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MCR_1799	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MCR_1808	COG0166	Belongs to the GPI family
MCR_1809	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MCR_1810	COG2937	Belongs to the GPAT DAPAT family
MCR_1811	COG1946	Acyl-CoA thioesterase
MCR_1814	COG0795	lipopolysaccharide-transporting ATPase activity
MCR_1815	COG0795	lipopolysaccharide-transporting ATPase activity
MCR_1817	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MCR_1818	COG1448	Aminotransferase
MCR_1819	COG0583	DNA-binding transcription factor activity
MCR_1820	COG0387	Pfam Sodium calcium exchanger
MCR_1821	COG1253	flavin adenine dinucleotide binding
MCR_1822	COG1028	Short-chain dehydrogenase reductase Sdr
MCR_1823	COG0546	phosphoglycolate phosphatase activity
MCR_1825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MCR_1832	COG1660	Displays ATPase and GTPase activities
MCR_1833	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MCR_1834	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MCR_1835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MCR_1836	COG0617	tRNA 3'-terminal CCA addition
MCR_1837	COG1596	polysaccharide export
MCR_1837	COG1555	photosystem II stabilization
MCR_1838	COG3956	TIGRFAM MazG family protein
MCR_1846	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MCR_1848	COG0425	Belongs to the sulfur carrier protein TusA family
MCR_1850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MCR_1851	COG1678	Uncharacterized ACR, COG1678
MCR_1852	COG0497	DNA recombination
MCR_1853	COG0242	peptide deformylase activity
MCR_1855	COG0131	Imidazoleglycerol-phosphate dehydratase
MCR_1856	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MCR_1868	COG1121	(ABC) transporter
MCR_1869	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MCR_1870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MCR_1873	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MCR_1874	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MCR_1881	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MCR_1884	COG2828	Protein conserved in bacteria
MCR_1887	COG2813	Specifically methylates the guanine in position
MCR_1893	COG0758	DNA mediated transformation
MCR_1896	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MCR_1896	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MCR_1899	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MCR_1899	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MCR_1900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MCR_1901	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MCR_1902	COG0706	membrane insertase activity
MCR_1903	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MCR_1904	COG0594	ribonuclease P activity