locus-tag	class	description
HH214_00025	COG1480	7TM receptor with intracellular HD hydrolase
HH214_00035	COG3104	oligopeptide transport
HH214_00040	COG0463	Glycosyl transferase, family 2
HH214_00045	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HH214_00050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HH214_00060	COG2153	protein acetylation
HH214_00070	COG0191	fructose-bisphosphate aldolase activity
HH214_00075	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HH214_00085	COG1104	cysteine desulfurase activity
HH214_00090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HH214_00120	COG0513	Belongs to the DEAD box helicase family
HH214_00145	COG1501	Belongs to the glycosyl hydrolase 31 family
HH214_00155	COG0436	Aminotransferase
HH214_00160	COG2201	protein-glutamate methylesterase activity
HH214_00165	COG2205	protein histidine kinase activity
HH214_00195	COG0656	L-ascorbic acid biosynthetic process
HH214_00225	COG0438	transferase activity, transferring glycosyl groups
HH214_00250	COG0438	transferase activity, transferring glycosyl groups
HH214_00265	COG0489	protein tyrosine kinase activity
HH214_00265	COG3206	protein involved in exopolysaccharide biosynthesis
HH214_00280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH214_00285	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HH214_00290	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HH214_00320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HH214_00325	COG0366	Alpha amylase catalytic
HH214_00330	COG0366	Alpha amylase catalytic
HH214_00340	COG0596	Alpha beta hydrolase
HH214_00345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HH214_00345	COG2755	lipolytic protein G-D-S-L family
HH214_00370	COG0012	GTP binding
HH214_00375	COG2239	Acts as a magnesium transporter
HH214_00385	COG1132	(ABC) transporter
HH214_00390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HH214_00400	COG1862	Preprotein translocase
HH214_00410	COG0237	dephospho-CoA kinase activity
HH214_00435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HH214_00450	COG0167	dihydroorotate dehydrogenase activity
HH214_00470	COG0488	(ABC) transporter
HH214_00480	COG1607	acyl-coa hydrolase
HH214_00490	COG0667	Aldo Keto reductase
HH214_00500	COG5002	protein histidine kinase activity
HH214_00500	COG2198	Histidine kinase
HH214_00500	COG0784	Response regulator, receiver
HH214_00520	COG0784	Response regulator, receiver
HH214_00520	COG2205	protein histidine kinase activity
HH214_00525	COG0525	valine-tRNA ligase activity
HH214_00530	COG0628	permease
HH214_00550	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HH214_00580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HH214_00590	COG0180	Tryptophanyl-tRNA synthetase
HH214_00595	COG1428	Deoxynucleoside kinase
HH214_00600	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HH214_00605	COG4942	peptidase
HH214_00625	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HH214_00640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HH214_00640	COG1199	ATP-dependent helicase activity
HH214_00660	COG0583	DNA-binding transcription factor activity
HH214_00675	COG0577	efflux transmembrane transporter activity
HH214_00685	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HH214_00685	COG0321	lipoyl(octanoyl) transferase activity
HH214_00695	COG1674	ftsk spoiiie
HH214_00710	COG0656	L-ascorbic acid biosynthetic process
HH214_00755	COG0165	Argininosuccinate lyase
HH214_00760	COG0629	single-stranded DNA binding
HH214_00765	COG4895	conserved protein (DUF2196)
HH214_00780	COG1801	Protein of unknown function DUF72
HH214_00785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HH214_00815	COG0477	Major facilitator Superfamily
HH214_00820	COG0589	response to stress
HH214_00820	COG0475	glutathione-regulated potassium exporter activity
HH214_00825	COG0667	Aldo Keto reductase
HH214_00835	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_00850	COG0564	pseudouridine synthase activity
HH214_00885	COG0640	Transcriptional regulator
HH214_00890	COG1902	pentaerythritol trinitrate reductase activity
HH214_00910	COG0724	RNA recognition motif
HH214_00935	COG5002	protein histidine kinase activity
HH214_00940	COG4251	negative regulation of phosphorylation
HH214_00945	COG2197	response regulator
HH214_00995	COG5002	protein histidine kinase activity
HH214_01010	COG0531	amino acid
HH214_01015	COG2160	L-arabinose isomerase activity
HH214_01025	COG1069	ribulokinase activity
HH214_01155	COG1216	Glycosyl transferase, family 2
HH214_01160	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HH214_01175	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HH214_01195	COG2814	Major facilitator Superfamily
HH214_01205	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HH214_01220	COG0484	heat shock protein binding
HH214_01235	COG2721	sulfolactate sulfo-lyase activity
HH214_01240	COG0246	Mannitol dehydrogenase
HH214_01255	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HH214_01270	COG4677	pectinesterase activity
HH214_01275	COG2755	lipolytic protein G-D-S-L family
HH214_01285	COG4771	TonB-dependent receptor
HH214_01295	COG5434	Belongs to the glycosyl hydrolase 28 family
HH214_01300	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HH214_01310	COG0596	Alpha beta hydrolase
HH214_01310	COG0508	dehydrogenase complex catalyzes the overall conversion of
HH214_01320	COG3237	CsbD-like
HH214_01325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HH214_01330	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HH214_01335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HH214_01345	COG0552	protein localization to endoplasmic reticulum
HH214_01350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HH214_01355	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HH214_01425	COG4977	sequence-specific DNA binding
HH214_01425	COG1917	Cupin 2, conserved barrel domain protein
HH214_01440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HH214_01445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HH214_01465	COG0738	Major facilitator superfamily
HH214_01490	COG1484	DNA-dependent DNA replication
HH214_01495	COG4584	PFAM Integrase catalytic
HH214_01495	COG2390	Transcriptional regulator
HH214_01525	COG0154	amidase activity
HH214_01535	COG4771	TonB-dependent receptor
HH214_01540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HH214_01545	COG2323	membrane
HH214_01585	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HH214_01590	COG0517	IMP dehydrogenase activity
HH214_01590	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HH214_01600	COG1012	belongs to the aldehyde dehydrogenase family
HH214_01605	COG0482	sulfurtransferase activity
HH214_01610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HH214_01610	COG1754	DNA topoisomerase type I activity
HH214_01635	COG0557	exoribonuclease II activity
HH214_01650	COG0004	ammonium transporteR
HH214_01655	COG1007	ATP synthesis coupled electron transport
HH214_01665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HH214_01670	COG0713	ATP synthesis coupled electron transport
HH214_01685	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HH214_01690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HH214_01705	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HH214_01710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HH214_01725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HH214_01755	COG2226	methyltransferase
HH214_01770	COG0745	RESPONSE REGULATOR receiver
HH214_01780	COG1741	Belongs to the pirin family
HH214_01795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HH214_01800	COG0300	oxidoreductase activity
HH214_01815	COG0531	amino acid
HH214_01820	COG0671	phosphoesterase, PA-phosphatase related
HH214_01845	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HH214_01850	COG2514	catechol 2,3-dioxygenase activity
HH214_01855	COG0671	phosphoesterase, PA-phosphatase related
HH214_01860	COG3158	transport of potassium into the cell
HH214_01870	COG0179	Fumarylacetoacetate (FAA) hydrolase
HH214_01880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HH214_01885	COG1595	DNA-templated transcription, initiation
HH214_01910	COG0438	transferase activity, transferring glycosyl groups
HH214_01915	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HH214_01940	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HH214_01950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HH214_01960	COG1301	dicarboxylic acid transport
HH214_01970	COG0495	leucyl-tRNA aminoacylation
HH214_01980	COG0753	catalase activity
HH214_01995	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HH214_02000	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HH214_02015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HH214_02025	COG0492	ferredoxin-NADP+ reductase activity
HH214_02050	COG0517	IMP dehydrogenase activity
HH214_02050	COG0516	GMP reductase activity
HH214_02065	COG3590	peptidase
HH214_02075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HH214_02085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HH214_02085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HH214_02115	COG0784	Response regulator, receiver
HH214_02115	COG2205	protein histidine kinase activity
HH214_02140	COG2197	response regulator
HH214_02155	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HH214_02165	COG1475	DNA binding
HH214_02170	COG1192	Involved in chromosome partitioning
HH214_02175	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HH214_02225	COG0196	riboflavin kinase activity
HH214_02240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HH214_02260	COG3956	TIGRFAM MazG family protein
HH214_02270	COG1595	DNA-templated transcription, initiation
HH214_02290	COG3876	Protein conserved in bacteria
HH214_02295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HH214_02310	COG0564	pseudouridine synthase activity
HH214_02320	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HH214_02340	COG0386	Belongs to the glutathione peroxidase family
HH214_02350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HH214_02355	COG0735	belongs to the Fur family
HH214_02360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HH214_02365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HH214_02370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HH214_02375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HH214_02380	COG0681	Belongs to the peptidase S26 family
HH214_02390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HH214_02405	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HH214_02410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH214_02450	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HH214_02455	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HH214_02480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HH214_02520	COG2885	chlorophyll binding
HH214_02550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HH214_02555	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_02580	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HH214_02595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH214_02605	COG2207	Transcriptional regulator
HH214_02620	COG2814	Major facilitator Superfamily
HH214_02635	COG0583	DNA-binding transcription factor activity
HH214_02640	COG2855	membrane
HH214_02660	COG3546	catalase activity
HH214_02695	COG4297	protein containing double-stranded beta helix domain
HH214_02705	COG0583	DNA-binding transcription factor activity
HH214_02710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HH214_02715	COG4221	oxidoreductase activity
HH214_02725	COG2815	serine threonine protein kinase
HH214_02725	COG0515	serine threonine protein kinase
HH214_02735	COG0772	Belongs to the SEDS family
HH214_02740	COG0631	protein serine/threonine phosphatase activity
HH214_02755	COG0288	reversible hydration of carbon dioxide
HH214_02760	COG4221	oxidoreductase activity
HH214_02775	COG3254	rhamnose metabolic process
HH214_02780	COG3250	beta-galactosidase activity
HH214_02785	COG3507	Belongs to the glycosyl hydrolase 43 family
HH214_02800	COG1309	transcriptional regulator
HH214_02805	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_02810	COG1523	belongs to the glycosyl hydrolase 13 family
HH214_02830	COG0596	Alpha beta hydrolase
HH214_02840	COG3046	protein related to deoxyribodipyrimidine photolyase
HH214_02845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HH214_02870	COG0028	Belongs to the TPP enzyme family
HH214_02875	COG0579	oxidoreductase
HH214_02880	COG0514	ATP-dependent DNA helicase (RecQ)
HH214_02935	COG1012	belongs to the aldehyde dehydrogenase family
HH214_02945	COG0800	Aldolase
HH214_02955	COG1904	glucuronate isomerase
HH214_02965	COG2885	chlorophyll binding
HH214_02970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HH214_02985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HH214_02985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HH214_03005	COG0187	DNA topoisomerase II activity
HH214_03015	COG0590	tRNA wobble adenosine to inosine editing
HH214_03025	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HH214_03035	COG2171	N-acyltransferase activity
HH214_03045	COG0009	L-threonylcarbamoyladenylate synthase
HH214_03050	COG0772	Belongs to the SEDS family
HH214_03055	COG0768	penicillin binding
HH214_03070	COG1077	Cell shape determining protein MreB Mrl
HH214_03075	COG0138	bifunctional purine biosynthesis protein purh
HH214_03085	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HH214_03095	COG0577	efflux transmembrane transporter activity
HH214_03100	COG0723	plastoquinol--plastocyanin reductase activity
HH214_03100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HH214_03125	COG0564	pseudouridine synthase activity
HH214_03130	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HH214_03135	COG0505	Belongs to the CarA family
HH214_03150	COG1131	(ABC) transporter
HH214_03165	COG0148	phosphopyruvate hydratase activity
HH214_03170	COG0513	Belongs to the DEAD box helicase family
HH214_03185	COG0612	Peptidase, M16
HH214_03205	COG0508	dehydrogenase complex catalyzes the overall conversion of
HH214_03215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HH214_03220	COG4682	membrane
HH214_03230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HH214_03250	COG0747	negative chemotaxis
HH214_03260	COG1968	undecaprenyl-diphosphatase activity
HH214_03270	COG2177	Part of the ABC transporter FtsEX involved in
HH214_03280	COG1917	Cupin 2, conserved barrel domain protein
HH214_03280	COG4977	sequence-specific DNA binding
HH214_03285	COG4221	oxidoreductase activity
HH214_03290	COG0667	Aldo Keto reductase
HH214_03300	COG1132	(ABC) transporter
HH214_03305	COG0101	tRNA pseudouridine synthase activity
HH214_03325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HH214_03330	COG1595	DNA-templated transcription, initiation
HH214_03340	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HH214_03355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HH214_03360	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_03365	COG0667	Aldo Keto reductase
HH214_03395	COG1764	response to oxidative stress
HH214_03405	COG0412	Dienelactone hydrolase
HH214_03430	COG1917	Cupin 2, conserved barrel domain protein
HH214_03430	COG4977	sequence-specific DNA binding
HH214_03495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HH214_03525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH214_03560	COG2989	Protein conserved in bacteria
HH214_03570	COG1528	Iron-storage protein
HH214_03580	COG0604	alcohol dehydrogenase
HH214_03585	COG0542	response to heat
HH214_03590	COG5002	protein histidine kinase activity
HH214_03605	COG2890	protein-(glutamine-N5) methyltransferase activity
HH214_03630	COG1136	(ABC) transporter
HH214_03630	COG0577	efflux transmembrane transporter activity
HH214_03650	COG3590	peptidase
HH214_03690	COG1242	4 iron, 4 sulfur cluster binding
HH214_03695	COG0667	Aldo Keto reductase
HH214_03775	COG0497	DNA recombination
HH214_03820	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HH214_03825	COG1629	transport
HH214_03825	COG4206	TonB-dependent receptor
HH214_03830	COG0366	Alpha amylase catalytic
HH214_03880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HH214_03890	COG2205	protein histidine kinase activity
HH214_03895	COG0667	Aldo Keto reductase
HH214_03900	COG1012	belongs to the aldehyde dehydrogenase family
HH214_03910	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HH214_03915	COG1663	tetraacyldisaccharide 4'-kinase activity
HH214_03925	COG1138	Cytochrome C-type biogenesis protein
HH214_03940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HH214_03950	COG0288	reversible hydration of carbon dioxide
HH214_03980	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HH214_03985	COG0563	adenylate kinase activity
HH214_04000	COG0714	Associated with various cellular activities
HH214_04040	COG0671	phosphoesterase, PA-phosphatase related
HH214_04045	COG1131	(ABC) transporter
HH214_04065	COG0592	DNA-directed DNA polymerase activity
HH214_04080	COG0586	Pfam SNARE associated Golgi protein
HH214_04125	COG0488	(ABC) transporter
HH214_04160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HH214_04165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HH214_04170	COG0556	nucleotide-excision repair
HH214_04195	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HH214_04205	COG0542	response to heat
HH214_04210	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_04215	COG2723	6-phospho-beta-galactosidase activity
HH214_04235	COG0745	RESPONSE REGULATOR receiver
HH214_04245	COG0673	inositol 2-dehydrogenase activity
HH214_04265	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HH214_04395	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HH214_04440	COG0667	Aldo Keto reductase
HH214_04450	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_04455	COG1733	regulation of RNA biosynthetic process
HH214_04460	COG2135	peptidase activity
HH214_04470	COG2957	Belongs to the agmatine deiminase family
HH214_04475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH214_04475	COG2010	Cytochrome c
HH214_04485	COG3275	phosphorelay sensor kinase activity
HH214_04490	COG3279	Response regulator of the LytR AlgR family
HH214_04515	COG0745	RESPONSE REGULATOR receiver
HH214_04525	COG0477	Major facilitator Superfamily
HH214_04550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HH214_04555	COG2226	methyltransferase
HH214_04565	COG4251	negative regulation of phosphorylation
HH214_04585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HH214_04605	COG0538	isocitrate dehydrogenase activity
HH214_04610	COG1482	cell wall glycoprotein biosynthetic process
HH214_04685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HH214_04690	COG0564	pseudouridine synthase activity
HH214_04720	COG4771	TonB-dependent receptor
HH214_04755	COG1501	Belongs to the glycosyl hydrolase 31 family
HH214_04785	COG0596	Alpha beta hydrolase
HH214_04800	COG2755	lipolytic protein G-D-S-L family
HH214_04815	COG3401	FG-GAP repeat protein
HH214_04825	COG1629	transport
HH214_04835	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HH214_04840	COG0702	epimerase
HH214_04845	COG4771	TonB-dependent receptor
HH214_04860	COG1556	Lactate utilization protein
HH214_04865	COG1139	Iron-sulfur cluster binding protein
HH214_04870	COG0247	lactate metabolic process
HH214_04880	COG4952	isomerase
HH214_04885	COG3347	Dehydrogenase
HH214_04885	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_04910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HH214_04915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HH214_04945	COG3279	Response regulator of the LytR AlgR family
HH214_04980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HH214_04995	COG2205	protein histidine kinase activity
HH214_04995	COG0784	Response regulator, receiver
HH214_05020	COG2304	oxidoreductase activity
HH214_05025	COG2304	oxidoreductase activity
HH214_05040	COG0714	Associated with various cellular activities
HH214_05065	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HH214_05075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HH214_05090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HH214_05095	COG1253	flavin adenine dinucleotide binding
HH214_05105	COG0586	Pfam SNARE associated Golgi protein
HH214_05115	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HH214_05140	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HH214_05165	COG1597	lipid kinase activity
HH214_05170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HH214_05180	COG2201	protein-glutamate methylesterase activity
HH214_05190	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HH214_05190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HH214_05195	COG1137	ATPase activity
HH214_05205	COG0393	Putative heavy-metal-binding
HH214_05215	COG0604	alcohol dehydrogenase
HH214_05225	COG2267	carboxylic ester hydrolase activity
HH214_05230	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HH214_05240	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HH214_05250	COG0739	heme binding
HH214_05285	COG0659	secondary active sulfate transmembrane transporter activity
HH214_05310	COG1215	transferase activity, transferring glycosyl groups
HH214_05315	COG0233	cytoplasmic translational termination
HH214_05320	COG1132	(ABC) transporter
HH214_05330	COG1649	PFAM Uncharacterised BCR, COG1649
HH214_05335	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_05350	COG1201	RNA secondary structure unwinding
HH214_05370	COG0791	NLP P60 protein
HH214_05375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HH214_05400	COG1629	transport
HH214_05415	COG0306	phosphate transporter
HH214_05425	COG5002	protein histidine kinase activity
HH214_05440	COG3424	synthase
HH214_05450	COG2706	6-phosphogluconolactonase activity
HH214_05465	COG0438	transferase activity, transferring glycosyl groups
HH214_05470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HH214_05475	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HH214_05480	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HH214_05500	COG0215	cysteine-tRNA ligase activity
HH214_05510	COG0714	Associated with various cellular activities
HH214_05515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HH214_05525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HH214_05535	COG0037	tRNA processing
HH214_05565	COG3118	belongs to the thioredoxin family
HH214_05595	COG0484	heat shock protein binding
HH214_05605	COG4771	TonB-dependent receptor
HH214_05615	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_05620	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HH214_05625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HH214_05630	COG1174	glycine betaine transport
HH214_05635	COG1125	glycine betaine transport
HH214_05635	COG0517	IMP dehydrogenase activity
HH214_05640	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HH214_05645	COG0673	inositol 2-dehydrogenase activity
HH214_05730	COG1484	DNA-dependent DNA replication
HH214_05735	COG2390	Transcriptional regulator
HH214_05735	COG4584	PFAM Integrase catalytic
HH214_05760	COG2963	transposase activity
HH214_05770	COG0701	Predicted permease
HH214_05795	COG0668	transmembrane transport
HH214_05810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HH214_05830	COG1845	cytochrome c oxidase, subunit III
HH214_05845	COG0723	plastoquinol--plastocyanin reductase activity
HH214_05850	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HH214_05855	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_05880	COG4974	Belongs to the 'phage' integrase family
HH214_05900	COG4584	PFAM Integrase catalytic
HH214_05900	COG2390	Transcriptional regulator
HH214_05905	COG1484	DNA-dependent DNA replication
HH214_05915	COG1959	2 iron, 2 sulfur cluster binding
HH214_05920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HH214_05920	COG1017	nitric oxide dioxygenase activity
HH214_05930	COG0702	epimerase
HH214_05935	COG4771	TonB-dependent receptor
HH214_05950	COG0584	glycerophosphoryl diester phosphodiesterase
HH214_05955	COG4771	TonB-dependent receptor
HH214_05985	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HH214_05990	COG0735	belongs to the Fur family
HH214_05995	COG0523	cobalamin synthesis protein
HH214_06015	COG1136	(ABC) transporter
HH214_06025	COG0523	cobalamin synthesis protein
HH214_06040	COG0165	Argininosuccinate lyase
HH214_06045	COG0165	Argininosuccinate lyase
HH214_06050	COG4221	oxidoreductase activity
HH214_06055	COG2390	Transcriptional regulator
HH214_06055	COG4584	PFAM Integrase catalytic
HH214_06060	COG1484	DNA-dependent DNA replication
HH214_06105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HH214_06110	COG1674	ftsk spoiiie
HH214_06140	COG1401	restriction endodeoxyribonuclease activity
HH214_06165	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HH214_06220	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HH214_06230	COG4584	PFAM Integrase catalytic
HH214_06230	COG2390	Transcriptional regulator
HH214_06235	COG1484	DNA-dependent DNA replication
HH214_06240	COG0745	RESPONSE REGULATOR receiver
HH214_06255	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HH214_06260	COG1595	DNA-templated transcription, initiation
HH214_06295	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HH214_06295	COG4447	cellulose binding
HH214_06300	COG1472	Belongs to the glycosyl hydrolase 3 family
HH214_06315	COG5520	Belongs to the glycosyl hydrolase 30 family
HH214_06330	COG1629	transport
HH214_06355	COG1090	epimerase
HH214_06360	COG0415	Belongs to the DNA photolyase family
HH214_06390	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HH214_06440	COG3279	Response regulator of the LytR AlgR family
HH214_06445	COG3275	phosphorelay sensor kinase activity
HH214_06455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HH214_06455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HH214_06480	COG0405	Gamma-glutamyltransferase
HH214_06500	COG5002	protein histidine kinase activity
HH214_06520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HH214_06525	COG0179	Fumarylacetoacetate (FAA) hydrolase
HH214_06530	COG0667	Aldo Keto reductase
HH214_06590	COG1629	transport
HH214_06605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HH214_06610	COG3959	Transketolase, thiamine diphosphate binding domain
HH214_06615	COG3958	Transketolase
HH214_06625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HH214_06625	COG0116	Belongs to the methyltransferase superfamily
HH214_06640	COG1418	mRNA catabolic process
HH214_06660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HH214_06665	COG0251	oxidation-reduction process
HH214_06680	COG0006	proline dipeptidase activity
HH214_06685	COG0528	UMP kinase activity
HH214_06690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HH214_06695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HH214_06700	COG0052	Belongs to the universal ribosomal protein uS2 family
HH214_06705	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HH214_06710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HH214_06715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HH214_06725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HH214_06735	COG0436	Aminotransferase
HH214_06740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HH214_06750	COG0303	'Molybdopterin
HH214_06755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HH214_06765	COG0314	molybdopterin synthase activity
HH214_06775	COG3842	ATPase activity
HH214_06795	COG0746	molybdenum cofactor guanylyltransferase activity
HH214_06800	COG0315	cyclic pyranopterin monophosphate synthase activity
HH214_06800	COG0746	molybdenum cofactor guanylyltransferase activity
HH214_06810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH214_06815	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HH214_06820	COG2080	2 iron, 2 sulfur cluster binding
HH214_06825	COG2080	2 iron, 2 sulfur cluster binding
HH214_06830	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HH214_06835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH214_06890	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HH214_06910	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HH214_06915	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HH214_06920	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HH214_06925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HH214_06930	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HH214_06935	COG0356	it plays a direct role in the translocation of protons across the membrane
HH214_06955	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HH214_06960	COG0322	excinuclease ABC activity
HH214_06990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HH214_07010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HH214_07065	COG4106	trans-aconitate 2-methyltransferase activity
HH214_07125	COG2322	membrane
HH214_07150	COG0109	protoheme IX farnesyltransferase activity
HH214_07155	COG1612	heme a metabolic process
HH214_07160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HH214_07190	COG0437	4 iron, 4 sulfur cluster binding
HH214_07215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HH214_07220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HH214_07230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HH214_07240	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HH214_07260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HH214_07275	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HH214_07280	COG0047	phosphoribosylformylglycinamidine synthase activity
HH214_07295	COG2274	protein secretion by the type I secretion system
HH214_07300	COG1187	pseudouridine synthase activity
HH214_07310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HH214_07325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HH214_07330	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HH214_07335	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HH214_07350	COG2972	Histidine kinase
HH214_07355	COG3279	Response regulator of the LytR AlgR family
HH214_07360	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_07365	COG1381	Involved in DNA repair and RecF pathway recombination
HH214_07380	COG1201	RNA secondary structure unwinding
HH214_07395	COG1074	ATP-dependent DNA helicase activity
HH214_07400	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HH214_07405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HH214_07505	COG2205	protein histidine kinase activity
HH214_07505	COG0745	RESPONSE REGULATOR receiver
HH214_07505	COG3292	Two component regulator propeller
HH214_07530	COG1629	transport
HH214_07560	COG1902	pentaerythritol trinitrate reductase activity
HH214_07565	COG4977	sequence-specific DNA binding
HH214_07565	COG1917	Cupin 2, conserved barrel domain protein
HH214_07570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HH214_07650	COG1619	proteins homologs of microcin C7 resistance protein MccF
HH214_07680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HH214_07715	COG0792	nuclease activity
HH214_07720	COG0358	DNA primase activity
HH214_07730	COG0017	Asparaginyl-tRNA synthetase
HH214_07740	COG0156	8-amino-7-oxononanoate synthase activity
HH214_07745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HH214_07755	COG1309	transcriptional regulator
HH214_07770	COG4452	Inner membrane protein CreD
HH214_07780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HH214_07790	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HH214_07805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HH214_07810	COG3590	peptidase
HH214_07830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HH214_07835	COG0194	GDP metabolic process
HH214_07840	COG1561	YicC-like family, N-terminal region
HH214_07850	COG0571	ribonuclease III activity
HH214_07855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HH214_07860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HH214_07870	COG0469	pyruvate kinase activity
HH214_07890	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HH214_07900	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HH214_07925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HH214_07955	COG1705	Flagellar rod assembly protein muramidase FlgJ
HH214_07955	COG1388	LysM domain
HH214_07965	COG4122	O-methyltransferase activity
HH214_07970	COG0494	nUDIX hydrolase
HH214_07985	COG2195	Cleaves the N-terminal amino acid of tripeptides
HH214_07990	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HH214_07995	COG0470	DNA polymerase III
HH214_08000	COG1774	PSP1 C-terminal conserved region
HH214_08045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HH214_08050	COG0124	histidyl-tRNA synthetase
HH214_08065	COG0708	Exodeoxyribonuclease III
HH214_08090	COG0601	transmembrane transport
HH214_08105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HH214_08110	COG1793	dna ligase
HH214_08115	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HH214_08115	COG1793	dna ligase
HH214_08130	COG1446	asparaginase
HH214_08135	COG4242	Belongs to the peptidase S51 family
HH214_08140	COG0189	ligase activity
HH214_08140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HH214_08155	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HH214_08180	COG1472	Belongs to the glycosyl hydrolase 3 family
HH214_08200	COG1132	(ABC) transporter
HH214_08205	COG0210	DNA helicase
HH214_08225	COG5002	protein histidine kinase activity
HH214_08255	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HH214_08260	COG1228	amidohydrolase
HH214_08265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HH214_08285	COG0134	indole-3-glycerol-phosphate synthase activity
HH214_08295	COG0577	efflux transmembrane transporter activity
HH214_08295	COG1136	(ABC) transporter
HH214_08300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HH214_08310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HH214_08315	COG0545	Peptidyl-prolyl cis-trans isomerase
HH214_08320	COG0545	Peptidyl-prolyl cis-trans isomerase
HH214_08325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HH214_08350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HH214_08370	COG1309	transcriptional regulator
HH214_08385	COG0300	oxidoreductase activity
HH214_08390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HH214_08395	COG2321	neutral zinc metallopeptidase
HH214_08415	COG0779	Required for maturation of 30S ribosomal subunits
HH214_08420	COG0195	Participates in both transcription termination and antitermination
HH214_08425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HH214_08425	COG5180	pathogenesis
HH214_08435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HH214_08445	COG1522	sequence-specific DNA binding
HH214_08450	COG2183	response to ionizing radiation
HH214_08470	COG0022	dehydrogenase e1 component
HH214_08470	COG0508	dehydrogenase complex catalyzes the overall conversion of
HH214_08475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HH214_08475	COG2755	lipolytic protein G-D-S-L family
HH214_08495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HH214_08510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HH214_08515	COG4591	ABC-type transport system involved in lipoprotein release permease component
HH214_08525	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HH214_08545	COG0793	Belongs to the peptidase S41A family
HH214_08565	COG1505	serine-type exopeptidase activity
HH214_08575	COG0667	Aldo Keto reductase
HH214_08580	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HH214_08585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HH214_08600	COG5002	protein histidine kinase activity
HH214_08845	COG4206	TonB-dependent receptor
HH214_08845	COG1629	transport
HH214_08850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HH214_08920	COG0745	RESPONSE REGULATOR receiver
HH214_08925	COG2217	Heavy metal translocating P-type atpase
HH214_08945	COG2132	Multicopper oxidase
HH214_08990	COG2132	Multicopper oxidase
HH214_09005	COG0745	RESPONSE REGULATOR receiver
HH214_09010	COG5002	protein histidine kinase activity
HH214_09030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HH214_09035	COG0671	phosphoesterase, PA-phosphatase related
HH214_09045	COG0671	phosphoesterase, PA-phosphatase related
HH214_09050	COG1742	UPF0060 membrane protein
HH214_09070	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_09075	COG1917	Cupin 2, conserved barrel domain protein
HH214_09075	COG4977	sequence-specific DNA binding
HH214_09145	COG0629	single-stranded DNA binding
HH214_09165	COG5002	protein histidine kinase activity
HH214_09170	COG5002	protein histidine kinase activity
HH214_09230	COG0300	oxidoreductase activity
HH214_09260	COG0148	phosphopyruvate hydratase activity
HH214_09270	COG0038	chloride channel
HH214_09280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HH214_09290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HH214_09305	COG0671	phosphoesterase, PA-phosphatase related
HH214_09310	COG0588	phosphoglycerate mutase activity
HH214_09320	COG3258	Cytochrome c
HH214_09340	COG0450	alkyl hydroperoxide reductase
HH214_09350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HH214_09360	COG0583	DNA-binding transcription factor activity
HH214_09400	COG0730	response to heat
HH214_09410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HH214_09435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HH214_09445	COG2855	membrane
HH214_09455	COG0701	Predicted permease
HH214_09470	COG2132	Multicopper oxidase
HH214_09490	COG4974	Belongs to the 'phage' integrase family
HH214_09505	COG4584	PFAM Integrase catalytic
HH214_09505	COG2390	Transcriptional regulator
HH214_09510	COG1484	DNA-dependent DNA replication
HH214_09605	COG4974	Belongs to the 'phage' integrase family
HH214_09645	COG4974	Belongs to the 'phage' integrase family
HH214_09660	COG1484	DNA-dependent DNA replication
HH214_09665	COG4584	PFAM Integrase catalytic
HH214_09665	COG2390	Transcriptional regulator
HH214_09685	COG2205	protein histidine kinase activity
HH214_09695	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HH214_09705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HH214_09740	COG3279	Response regulator of the LytR AlgR family
HH214_09745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HH214_09750	COG3275	phosphorelay sensor kinase activity
HH214_09795	COG1484	DNA-dependent DNA replication
HH214_09800	COG4584	PFAM Integrase catalytic
HH214_09800	COG2390	Transcriptional regulator
HH214_09850	COG4974	Belongs to the 'phage' integrase family
HH214_09860	COG0798	PFAM Bile acid sodium symporter
HH214_09865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HH214_09885	COG2205	protein histidine kinase activity
HH214_09885	COG0784	Response regulator, receiver
HH214_09900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HH214_09905	COG0386	Belongs to the glutathione peroxidase family
HH214_09915	COG1127	ABC transporter
HH214_09920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HH214_09935	COG0488	(ABC) transporter
HH214_09945	COG0445	tRNA wobble uridine modification
HH214_09955	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HH214_09970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HH214_09975	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HH214_09985	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HH214_09990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HH214_09995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HH214_10000	COG1131	(ABC) transporter
HH214_10005	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HH214_10010	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HH214_10010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HH214_10015	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HH214_10020	COG1078	dGTPase activity
HH214_10030	COG0802	atpase or kinase
HH214_10035	COG0686	Belongs to the AlaDH PNT family
HH214_10040	COG1295	ribonuclease BN
HH214_10055	COG2204	response regulator
HH214_10095	COG2801	Transposase and inactivated derivatives
HH214_10205	COG0464	growth
HH214_10215	COG1733	regulation of RNA biosynthetic process
HH214_10220	COG1733	regulation of RNA biosynthetic process
HH214_10245	COG4122	O-methyltransferase activity
HH214_10255	COG3275	phosphorelay sensor kinase activity
HH214_10260	COG3279	Response regulator of the LytR AlgR family
HH214_10275	COG1733	regulation of RNA biosynthetic process
HH214_10285	COG0604	alcohol dehydrogenase
HH214_10315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HH214_10325	COG4232	protein-disulfide reductase activity
HH214_10330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HH214_10340	COG1629	transport
HH214_10370	COG1902	pentaerythritol trinitrate reductase activity
HH214_10375	COG1733	regulation of RNA biosynthetic process
HH214_10400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HH214_10480	COG3279	Response regulator of the LytR AlgR family
HH214_10490	COG3275	phosphorelay sensor kinase activity
HH214_10500	COG0750	zinc metalloprotease
HH214_10510	COG0629	single-stranded DNA binding
HH214_10600	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HH214_10635	COG0793	Belongs to the peptidase S41A family
HH214_10640	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HH214_10650	COG0670	Belongs to the BI1 family
HH214_10655	COG3047	cAMP biosynthetic process
HH214_10670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HH214_10675	COG2972	Histidine kinase
HH214_10680	COG3279	Response regulator of the LytR AlgR family
HH214_10705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HH214_10720	COG0019	diaminopimelate decarboxylase activity
HH214_10725	COG4413	Urea transporter
HH214_10740	COG0514	ATP-dependent DNA helicase (RecQ)
HH214_10765	COG0339	signal peptide processing
HH214_10770	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HH214_10775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HH214_10780	COG2378	regulation of single-species biofilm formation
HH214_10790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HH214_10795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HH214_10815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HH214_10820	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_10825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HH214_10855	COG3250	beta-galactosidase activity
HH214_10865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HH214_10875	COG2954	triphosphatase activity
HH214_10885	COG1472	Belongs to the glycosyl hydrolase 3 family
HH214_10905	COG0667	Aldo Keto reductase
HH214_10915	COG0688	phosphatidylethanolamine metabolic process
HH214_10925	COG5002	protein histidine kinase activity
HH214_10950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HH214_10955	COG2967	ApaG domain
HH214_10985	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HH214_10990	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_11000	COG5002	protein histidine kinase activity
HH214_11030	COG1136	(ABC) transporter
HH214_11030	COG0577	efflux transmembrane transporter activity
HH214_11035	COG1136	(ABC) transporter
HH214_11040	COG0242	peptide deformylase activity
HH214_11050	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HH214_11055	COG0489	protein tyrosine kinase activity
HH214_11060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HH214_11070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HH214_11075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HH214_11080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HH214_11105	COG3291	Pkd domain containing protein
HH214_11110	COG3250	beta-galactosidase activity
HH214_11115	COG1472	Belongs to the glycosyl hydrolase 3 family
HH214_11120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HH214_11125	COG1472	Belongs to the glycosyl hydrolase 3 family
HH214_11140	COG0673	inositol 2-dehydrogenase activity
HH214_11155	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HH214_11175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HH214_11200	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HH214_11205	COG0612	Peptidase, M16
HH214_11210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HH214_11220	COG2318	DinB family
HH214_11245	COG1131	(ABC) transporter
HH214_11265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HH214_11270	COG0083	homoserine kinase activity
HH214_11280	COG1162	GTPase activity
HH214_11285	COG1490	D-aminoacyl-tRNA deacylase activity
HH214_11290	COG1694	Mazg nucleotide pyrophosphohydrolase
HH214_11295	COG0577	efflux transmembrane transporter activity
HH214_11300	COG2045	Belongs to the ComB family
HH214_11305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HH214_11315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HH214_11345	COG1215	transferase activity, transferring glycosyl groups
HH214_11375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HH214_11385	COG2201	protein-glutamate methylesterase activity
HH214_11420	COG4948	Mandelate Racemase Muconate Lactonizing
HH214_11430	COG2207	Transcriptional regulator
HH214_11430	COG3708	Transcriptional regulator
HH214_11445	COG3118	belongs to the thioredoxin family
HH214_11485	COG5002	protein histidine kinase activity
HH214_11485	COG2205	protein histidine kinase activity
HH214_11485	COG0784	Response regulator, receiver
HH214_11510	COG3853	Toxic anion resistance protein (TelA)
HH214_11520	COG0861	Integral membrane protein TerC family
HH214_11535	COG4464	protein tyrosine phosphatase activity
HH214_11565	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HH214_11570	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HH214_11595	COG0509	glycine decarboxylation via glycine cleavage system
HH214_11605	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HH214_11610	COG1139	Iron-sulfur cluster binding protein
HH214_11615	COG2234	aminopeptidase activity
HH214_11625	COG4771	TonB-dependent receptor
HH214_11630	COG0561	phosphatase activity
HH214_11650	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HH214_11655	COG2942	2-epimerase
HH214_11660	COG3345	alpha-galactosidase
HH214_11670	COG4124	Belongs to the glycosyl hydrolase 26 family
HH214_11675	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HH214_11675	COG2755	lipolytic protein G-D-S-L family
HH214_11680	COG2080	2 iron, 2 sulfur cluster binding
HH214_11685	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HH214_11690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HH214_11695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HH214_11775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HH214_11785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HH214_11790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HH214_11795	COG5658	integral membrane protein
HH214_11800	COG0590	tRNA wobble adenosine to inosine editing
HH214_11805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HH214_11815	COG0604	alcohol dehydrogenase
HH214_11820	COG0543	2 iron, 2 sulfur cluster binding
HH214_11820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HH214_11825	COG0583	DNA-binding transcription factor activity
HH214_11830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HH214_11840	COG0297	glycogen (starch) synthase activity
HH214_11845	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HH214_11850	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HH214_11860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HH214_11865	COG4771	TonB-dependent receptor
HH214_11875	COG1619	proteins homologs of microcin C7 resistance protein MccF
HH214_11880	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HH214_11880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HH214_11915	COG2201	protein-glutamate methylesterase activity
HH214_11920	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HH214_11935	COG0835	chemotaxis
HH214_11940	COG0643	Histidine kinase
HH214_11940	COG2198	Histidine kinase
HH214_11945	COG0745	RESPONSE REGULATOR receiver
HH214_12000	COG0542	response to heat
HH214_12050	COG2885	chlorophyll binding
HH214_12075	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_12090	COG0562	UDP-galactopyranose mutase
HH214_12095	COG1216	Glycosyl transferase, family 2
HH214_12105	COG1216	Glycosyl transferase, family 2
HH214_12125	COG1858	cytochrome C peroxidase
HH214_12130	COG0698	ribose 5-phosphate isomerase
HH214_12135	COG0805	protein transport
HH214_12140	COG0439	Biotin carboxylase
HH214_12145	COG0511	ligase activity, forming carbon-carbon bonds
HH214_12150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HH214_12155	COG0416	fatty acid biosynthetic process
HH214_12160	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HH214_12180	COG1983	PspC domain protein
HH214_12190	COG4206	TonB-dependent receptor
HH214_12190	COG1629	transport
HH214_12240	COG0300	oxidoreductase activity
HH214_12245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HH214_12255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HH214_12280	COG4221	oxidoreductase activity
HH214_12305	COG0531	amino acid
HH214_12310	COG3685	Protein conserved in bacteria
HH214_12330	COG1053	succinate dehydrogenase
HH214_12340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HH214_12345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HH214_12350	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HH214_12360	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HH214_12365	COG0297	glycogen (starch) synthase activity
HH214_12375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HH214_12375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HH214_12380	COG2818	Glycosylase
HH214_12385	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_12390	COG2169	Transcriptional regulator
HH214_12390	COG1917	Cupin 2, conserved barrel domain protein
HH214_12405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HH214_12440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HH214_12475	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HH214_12480	COG0823	Involved in the tonB-independent uptake of proteins
HH214_12480	COG1506	peptidase
HH214_12480	COG4946	Tricorn protease homolog
HH214_12485	COG1160	GTP binding
HH214_12490	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HH214_12530	COG2963	transposase activity
HH214_12540	COG4771	TonB-dependent receptor
HH214_12545	COG4771	TonB-dependent receptor
HH214_12565	COG1733	regulation of RNA biosynthetic process
HH214_12595	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_12600	COG1309	transcriptional regulator
HH214_12615	COG4221	oxidoreductase activity
HH214_12640	COG1629	transport
HH214_12640	COG4206	TonB-dependent receptor
HH214_12645	COG0702	epimerase
HH214_12700	COG1917	Cupin 2, conserved barrel domain protein
HH214_12700	COG4977	sequence-specific DNA binding
HH214_12705	COG0604	alcohol dehydrogenase
HH214_12710	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_12715	COG1309	transcriptional regulator
HH214_12730	COG4191	Histidine kinase
HH214_12770	COG4771	TonB-dependent receptor
HH214_12780	COG4585	Histidine kinase
HH214_12785	COG2201	protein-glutamate methylesterase activity
HH214_12805	COG0629	single-stranded DNA binding
HH214_12815	COG4565	transcriptional regulatory protein
HH214_12820	COG3852	Histidine kinase
HH214_12845	COG0776	regulation of translation
HH214_12855	COG1530	ribonuclease E activity
HH214_12860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HH214_12900	COG0861	Integral membrane protein TerC family
HH214_12930	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_12935	COG0028	Belongs to the TPP enzyme family
HH214_12955	COG2755	lipolytic protein G-D-S-L family
HH214_12955	COG0657	acetylesterase activity
HH214_12980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HH214_12985	COG0402	S-adenosylhomocysteine deaminase activity
HH214_13000	COG0756	dUTP diphosphatase activity
HH214_13020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HH214_13025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HH214_13030	COG0154	amidase activity
HH214_13035	COG0741	lytic transglycosylase activity
HH214_13035	COG1388	LysM domain
HH214_13040	COG0281	malic enzyme
HH214_13040	COG0280	phosphate acetyltransferase
HH214_13045	COG0632	four-way junction helicase activity
HH214_13055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HH214_13065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HH214_13095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HH214_13100	COG0459	protein refolding
HH214_13105	COG0668	transmembrane transport
HH214_13130	COG0714	Associated with various cellular activities
HH214_13170	COG1760	l-serine dehydratase
HH214_13175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HH214_13185	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HH214_13195	COG1011	Hydrolase
HH214_13200	COG1216	Glycosyl transferase, family 2
HH214_13205	COG0438	transferase activity, transferring glycosyl groups
HH214_13220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HH214_13230	COG0024	Methionine aminopeptidase
HH214_13240	COG4948	Mandelate Racemase Muconate Lactonizing
HH214_13260	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HH214_13265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HH214_13270	COG2755	lipolytic protein G-D-S-L family
HH214_13295	COG3620	sequence-specific DNA binding
HH214_13300	COG0210	DNA helicase
HH214_13305	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_13310	COG2895	sulfate adenylyltransferase (ATP) activity
HH214_13315	COG0175	sulfate reduction
HH214_13320	COG0175	sulfate reduction
HH214_13325	COG0730	response to heat
HH214_13335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HH214_13340	COG4242	Belongs to the peptidase S51 family
HH214_13345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HH214_13350	COG1070	Carbohydrate kinase
HH214_13370	COG3661	Belongs to the glycosyl hydrolase 67 family
HH214_13375	COG1609	Transcriptional regulator
HH214_13380	COG1312	Catalyzes the dehydration of D-mannonate
HH214_13385	COG0252	asparaginase activity
HH214_13390	COG0084	hydrolase, TatD family'
HH214_13395	COG0545	Peptidyl-prolyl cis-trans isomerase
HH214_13400	COG0545	Peptidyl-prolyl cis-trans isomerase
HH214_13405	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HH214_13410	COG0105	UTP biosynthetic process
HH214_13425	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HH214_13435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HH214_13445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HH214_13450	COG1595	DNA-templated transcription, initiation
HH214_13465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HH214_13465	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HH214_13470	COG4191	Histidine kinase
HH214_13475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HH214_13480	COG0302	gtp cyclohydrolase
HH214_13495	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HH214_13500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HH214_13510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HH214_13515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HH214_13520	COG0857	belongs to the CobB CobQ family
HH214_13520	COG0280	phosphate acetyltransferase
HH214_13530	COG2204	response regulator
HH214_13560	COG1335	isochorismatase
HH214_13580	COG0406	alpha-ribazole phosphatase activity
HH214_13610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HH214_13615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH214_13660	COG3537	Alpha-1,2-mannosidase
HH214_13665	COG3292	Two component regulator propeller
HH214_13665	COG0745	RESPONSE REGULATOR receiver
HH214_13665	COG2205	protein histidine kinase activity
HH214_13670	COG1629	transport
HH214_13685	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HH214_13700	COG3250	beta-galactosidase activity
HH214_13715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HH214_13735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HH214_13740	COG0088	Forms part of the polypeptide exit tunnel
HH214_13745	COG0089	rRNA binding
HH214_13750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HH214_13755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HH214_13760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HH214_13765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HH214_13770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HH214_13775	COG0255	Belongs to the universal ribosomal protein uL29 family
HH214_13780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HH214_13785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HH214_13790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HH214_13795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HH214_13800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HH214_13805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HH214_13810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HH214_13815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HH214_13820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HH214_13825	COG1841	ribosomal large subunit assembly
HH214_13830	COG0200	Binds to the 23S rRNA
HH214_13845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HH214_13850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HH214_13855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HH214_13860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HH214_13865	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HH214_13870	COG0202	RNA polymerase activity
HH214_13875	COG0203	ribosomal protein L17
HH214_13890	COG0443	Heat shock 70 kDa protein
HH214_13910	COG1363	Peptidase, m42
HH214_13920	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HH214_13925	COG0181	hydroxymethylbilane synthase activity
HH214_13930	COG0113	porphobilinogen synthase activity
HH214_13940	COG5002	protein histidine kinase activity
HH214_13955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HH214_13965	COG1228	amidohydrolase
HH214_13990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HH214_13995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HH214_14000	COG4106	trans-aconitate 2-methyltransferase activity
HH214_14010	COG0066	3-isopropylmalate dehydratase activity
HH214_14020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HH214_14025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HH214_14030	COG0440	acetolactate synthase activity
HH214_14035	COG0028	Belongs to the TPP enzyme family
HH214_14040	COG0129	dihydroxy-acid dehydratase activity
HH214_14045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HH214_14050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HH214_14065	COG0604	alcohol dehydrogenase
HH214_14065	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_14065	COG3321	synthase
HH214_14085	COG0563	adenylate kinase activity
HH214_14095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HH214_14100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HH214_14120	COG0126	phosphoglycerate kinase activity
HH214_14140	COG1131	(ABC) transporter
HH214_14155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HH214_14160	COG4974	Belongs to the 'phage' integrase family
HH214_14210	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HH214_14215	COG0081	regulation of translation
HH214_14220	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HH214_14225	COG0222	ribosome binding
HH214_14230	COG0085	RNA polymerase activity
HH214_14235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HH214_14250	COG0489	protein tyrosine kinase activity
HH214_14250	COG3206	protein involved in exopolysaccharide biosynthesis
HH214_14255	COG1216	Glycosyl transferase, family 2
HH214_14280	COG0438	transferase activity, transferring glycosyl groups
HH214_14305	COG0463	Glycosyl transferase, family 2
HH214_14310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HH214_14315	COG0297	glycogen (starch) synthase activity
HH214_14320	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HH214_14325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH214_14335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH214_14340	COG2226	methyltransferase
HH214_14365	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HH214_14375	COG0617	tRNA 3'-terminal CCA addition
HH214_14385	COG0359	binds to the 23S rRNA
HH214_14390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HH214_14395	COG0360	Binds together with S18 to 16S ribosomal RNA
HH214_14410	COG1366	Belongs to the anti-sigma-factor antagonist family
HH214_14415	COG1366	Belongs to the anti-sigma-factor antagonist family
HH214_14420	COG2172	sigma factor antagonist activity
HH214_14425	COG2172	sigma factor antagonist activity
HH214_14430	COG5002	protein histidine kinase activity
HH214_14435	COG4585	Histidine kinase
HH214_14475	COG2885	chlorophyll binding
HH214_14505	COG3158	transport of potassium into the cell
HH214_14510	COG2204	response regulator
HH214_14535	COG1064	alcohol dehydrogenase
HH214_14545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HH214_14555	COG1309	transcriptional regulator
HH214_14580	COG1595	DNA-templated transcription, initiation
HH214_14625	COG2197	response regulator
HH214_14640	COG0488	(ABC) transporter
HH214_14645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HH214_14650	COG0494	nUDIX hydrolase
HH214_14655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HH214_14675	COG0268	Binds directly to 16S ribosomal RNA
HH214_14680	COG2003	Belongs to the UPF0758 family
HH214_14685	COG0784	Response regulator, receiver
HH214_14685	COG4191	Histidine kinase
HH214_14690	COG0745	RESPONSE REGULATOR receiver
HH214_14700	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HH214_14705	COG0463	Glycosyl transferase, family 2
HH214_14710	COG1331	Highly conserved protein containing a thioredoxin domain
HH214_14715	COG1047	Peptidyl-prolyl cis-trans
HH214_14730	COG1607	acyl-coa hydrolase
HH214_14745	COG1640	4-alpha-glucanotransferase
HH214_14765	COG0366	Alpha amylase catalytic
HH214_14770	COG0423	glycine-tRNA ligase activity
HH214_14780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HH214_14805	COG0745	RESPONSE REGULATOR receiver
HH214_14815	COG5002	protein histidine kinase activity
HH214_14820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HH214_14850	COG5002	protein histidine kinase activity
HH214_14855	COG0745	RESPONSE REGULATOR receiver
HH214_14865	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_14875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HH214_14880	COG1473	amidohydrolase
HH214_14890	COG0653	protein targeting
HH214_14895	COG0151	Belongs to the GarS family
HH214_14925	COG0217	transcriptional regulatory protein
HH214_14930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HH214_14935	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HH214_14950	COG0693	protein deglycase activity
HH214_14955	COG1233	COG1233 Phytoene dehydrogenase and related
HH214_14975	COG1215	transferase activity, transferring glycosyl groups
HH214_14985	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HH214_14995	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HH214_15030	COG0825	malonyl-CoA metabolic process
HH214_15050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HH214_15055	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HH214_15060	COG0193	aminoacyl-tRNA hydrolase activity
HH214_15070	COG1393	Belongs to the ArsC family
HH214_15090	COG1335	isochorismatase
HH214_15120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HH214_15125	COG0049	tRNA binding
HH214_15130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HH214_15135	COG0051	transcription antitermination factor activity, RNA binding
HH214_15140	COG1136	(ABC) transporter
HH214_15140	COG0577	efflux transmembrane transporter activity
HH214_15165	COG0038	chloride channel
HH214_15180	COG0745	RESPONSE REGULATOR receiver
HH214_15190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HH214_15210	COG4232	protein-disulfide reductase activity
HH214_15215	COG0205	6-phosphofructokinase activity
HH214_15220	COG0228	four-way junction DNA binding
HH214_15225	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HH214_15230	COG0336	Belongs to the RNA methyltransferase TrmD family
HH214_15235	COG0577	efflux transmembrane transporter activity
HH214_15235	COG1136	(ABC) transporter
HH214_15240	COG0335	large ribosomal subunit rRNA binding
HH214_15250	COG4771	TonB-dependent receptor
HH214_15265	COG0321	lipoyl(octanoyl) transferase activity
HH214_15275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HH214_15285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HH214_15295	COG0492	ferredoxin-NADP+ reductase activity
HH214_15300	COG3548	integral membrane protein
HH214_15310	COG1830	Aldolase
HH214_15325	COG0730	response to heat
HH214_15380	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_15390	COG2027	D-alanyl-D-alanine carboxypeptidase
HH214_15395	COG0531	amino acid
HH214_15400	COG0531	amino acid
HH214_15410	COG2095	MarC family integral membrane protein
HH214_15415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HH214_15415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HH214_15425	COG0519	Catalyzes the synthesis of GMP from XMP
HH214_15425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HH214_15440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HH214_15445	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HH214_15460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HH214_15620	COG4191	Histidine kinase
HH214_15620	COG0784	Response regulator, receiver
HH214_15630	COG0596	Alpha beta hydrolase
HH214_15635	COG5002	protein histidine kinase activity
HH214_15640	COG2205	protein histidine kinase activity
HH214_15755	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HH214_15765	COG1881	PFAM PEBP family protein
HH214_15775	COG1501	Belongs to the glycosyl hydrolase 31 family
HH214_15780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HH214_15795	COG2207	Transcriptional regulator
HH214_15805	COG3250	beta-galactosidase activity
HH214_15810	COG5002	protein histidine kinase activity
HH214_15825	COG4771	TonB-dependent receptor
HH214_15850	COG1612	heme a metabolic process
HH214_15855	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HH214_15885	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HH214_15890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HH214_15905	COG0415	Belongs to the DNA photolyase family
HH214_15925	COG3437	response regulator, receiver
HH214_15925	COG3850	Histidine kinase
HH214_15925	COG4999	Histidine kinase
HH214_15925	COG2205	protein histidine kinase activity
HH214_15930	COG2205	protein histidine kinase activity
HH214_15930	COG3437	response regulator, receiver
HH214_15930	COG3850	Histidine kinase
HH214_15930	COG4999	Histidine kinase
HH214_15950	COG1609	Transcriptional regulator
HH214_15960	COG3537	Alpha-1,2-mannosidase
HH214_15965	COG3537	Alpha-1,2-mannosidase
HH214_15970	COG1629	transport
HH214_15970	COG4206	TonB-dependent receptor
HH214_15985	COG0738	Major facilitator superfamily
HH214_15995	COG1764	response to oxidative stress
HH214_16005	COG1454	alcohol dehydrogenase
HH214_16010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HH214_16015	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HH214_16035	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_16045	COG3618	amidohydrolase
HH214_16050	COG1063	alcohol dehydrogenase
HH214_16070	COG3250	beta-galactosidase activity
HH214_16075	COG3408	Glycogen debranching enzyme
HH214_16085	COG3250	beta-galactosidase activity
HH214_16090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HH214_16095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HH214_16110	COG4771	TonB-dependent receptor
HH214_16115	COG0702	epimerase
HH214_16150	COG3250	beta-galactosidase activity
HH214_16155	COG3250	beta-galactosidase activity
HH214_16210	COG3940	Belongs to the glycosyl hydrolase 43 family
HH214_16230	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HH214_16235	COG1959	2 iron, 2 sulfur cluster binding
HH214_16240	COG1104	cysteine desulfurase activity
HH214_16330	COG2814	Major facilitator Superfamily
HH214_16355	COG2963	transposase activity
HH214_16370	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_16385	COG4221	oxidoreductase activity
HH214_16390	COG1733	regulation of RNA biosynthetic process
HH214_16405	COG1902	pentaerythritol trinitrate reductase activity
HH214_16425	COG1917	Cupin 2, conserved barrel domain protein
HH214_16425	COG4977	sequence-specific DNA binding
HH214_16455	COG4974	Belongs to the 'phage' integrase family
HH214_16465	COG0436	Aminotransferase
HH214_16495	COG0628	permease
HH214_16500	COG0750	zinc metalloprotease
HH214_16505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HH214_16520	COG0463	Glycosyl transferase, family 2
HH214_16520	COG1216	Glycosyl transferase, family 2
HH214_16545	COG1418	mRNA catabolic process
HH214_16580	COG1216	Glycosyl transferase, family 2
HH214_16580	COG0463	Glycosyl transferase, family 2
HH214_16600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HH214_16605	COG3132	Protein of unknown function, DUF480
HH214_16610	COG2001	Belongs to the MraZ family
HH214_16615	COG0275	rRNA processing
HH214_16630	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HH214_16635	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HH214_16640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HH214_16645	COG0772	Belongs to the SEDS family
HH214_16650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HH214_16655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HH214_16670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HH214_16675	COG0156	8-amino-7-oxononanoate synthase activity
HH214_16685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HH214_16695	COG0589	response to stress
HH214_16700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HH214_16710	COG0010	Belongs to the arginase family
HH214_16720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HH214_16780	COG0628	permease
HH214_16785	COG0813	purine-nucleoside phosphorylase activity
HH214_16805	COG0612	Peptidase, M16
HH214_16815	COG0673	inositol 2-dehydrogenase activity
HH214_16820	COG0667	Aldo Keto reductase
HH214_16825	COG0285	dihydrofolate synthase activity
HH214_16840	COG0811	peptide transport
HH214_16865	COG0604	alcohol dehydrogenase
HH214_16865	COG3321	synthase
HH214_16865	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_16875	COG0745	RESPONSE REGULATOR receiver
HH214_16890	COG4935	Belongs to the peptidase S8 family
HH214_16890	COG2234	aminopeptidase activity
HH214_16900	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_16910	COG1127	ABC transporter
HH214_16915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HH214_16925	COG0693	protein deglycase activity
HH214_16925	COG0753	catalase activity
HH214_16935	COG0738	Major facilitator superfamily
HH214_16940	COG1741	Belongs to the pirin family
HH214_16950	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_16955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HH214_16960	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HH214_16970	COG0544	peptidyl-prolyl cis-trans isomerase activity
HH214_16995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HH214_17040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HH214_17100	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HH214_17115	COG0116	Belongs to the methyltransferase superfamily
HH214_17115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HH214_17120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HH214_17125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HH214_17130	COG4221	oxidoreductase activity
HH214_17135	COG1983	PspC domain protein
HH214_17170	COG1595	DNA-templated transcription, initiation
HH214_17180	COG1301	dicarboxylic acid transport
HH214_17190	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HH214_17205	COG0726	polysaccharide deacetylase
HH214_17210	COG1058	Belongs to the CinA family
HH214_17210	COG1546	Belongs to the CinA family
HH214_17215	COG2255	four-way junction helicase activity
HH214_17220	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HH214_17225	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HH214_17245	COG0343	queuine tRNA-ribosyltransferase activity
HH214_17260	COG0357	Ribosomal RNA small subunit methyltransferase G
HH214_17270	COG0758	DNA mediated transformation
HH214_17270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HH214_17285	COG0859	PFAM glycosyl transferase family 9
HH214_17290	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HH214_17290	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HH214_17295	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HH214_17295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HH214_17305	COG0616	signal peptide processing
HH214_17325	COG1183	phosphatidylcholine synthase activity
HH214_17330	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HH214_17335	COG0284	orotidine-5'-phosphate decarboxylase activity
HH214_17345	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HH214_17350	COG0540	Belongs to the ATCase OTCase family
HH214_17360	COG0706	membrane insertase activity
HH214_17365	COG0504	CTP synthase activity
HH214_17380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HH214_17390	COG5654	RES domain protein
HH214_17425	COG0366	Alpha amylase catalytic
HH214_17435	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HH214_17450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HH214_17470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HH214_17485	COG0438	transferase activity, transferring glycosyl groups
HH214_17490	COG0438	transferase activity, transferring glycosyl groups
HH214_17500	COG0438	transferase activity, transferring glycosyl groups
HH214_17505	COG0438	transferase activity, transferring glycosyl groups
HH214_17520	COG0438	transferase activity, transferring glycosyl groups
HH214_17535	COG1216	Glycosyl transferase, family 2
HH214_17585	COG1216	Glycosyl transferase, family 2
HH214_17590	COG0562	UDP-galactopyranose mutase
HH214_17595	COG0438	transferase activity, transferring glycosyl groups
HH214_17615	COG0438	transferase activity, transferring glycosyl groups
HH214_17620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HH214_17630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HH214_17645	COG0438	transferase activity, transferring glycosyl groups
HH214_17660	COG0438	transferase activity, transferring glycosyl groups
HH214_17665	COG0110	maltose O-acetyltransferase activity
HH214_17675	COG1216	Glycosyl transferase, family 2
HH214_17695	COG2270	Major facilitator Superfamily
HH214_17700	COG0247	lactate metabolic process
HH214_17705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HH214_17710	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HH214_17715	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HH214_17720	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HH214_17740	COG0492	ferredoxin-NADP+ reductase activity
HH214_17760	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HH214_17775	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HH214_17780	COG0594	ribonuclease P activity
HH214_17785	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HH214_17805	COG2363	Small membrane protein
HH214_17810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HH214_17820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HH214_17825	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HH214_17845	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HH214_17865	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HH214_17870	COG0110	maltose O-acetyltransferase activity
HH214_17885	COG1022	Amp-dependent synthetase and ligase
HH214_17890	COG0316	Belongs to the HesB IscA family
HH214_17900	COG1104	cysteine desulfurase activity
HH214_17905	COG2814	Major facilitator Superfamily
HH214_17910	COG0254	rRNA binding
HH214_17920	COG0149	triose-phosphate isomerase activity
HH214_17925	COG2264	protein methyltransferase activity
HH214_17930	COG2910	NAD(P)H-binding
HH214_17935	COG1959	2 iron, 2 sulfur cluster binding
HH214_17940	COG1611	Belongs to the LOG family
HH214_17950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HH214_17960	COG4221	oxidoreductase activity
HH214_17965	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_17975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HH214_17980	COG0135	phosphoribosylanthranilate isomerase activity
HH214_17985	COG0133	tryptophan synthase activity
HH214_17990	COG0159	tryptophan synthase activity
HH214_17995	COG0009	L-threonylcarbamoyladenylate synthase
HH214_18000	COG5002	protein histidine kinase activity
HH214_18010	COG0045	succinate-CoA ligase (ADP-forming) activity
HH214_18015	COG1136	(ABC) transporter
HH214_18035	COG1196	nuclear chromosome segregation
HH214_18045	COG1121	(ABC) transporter
HH214_18065	COG1515	deoxyribonuclease V activity
HH214_18070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HH214_18075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HH214_18080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HH214_18090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HH214_18095	COG0038	chloride channel
HH214_18120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HH214_18125	COG0346	lactoylglutathione lyase activity
HH214_18130	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HH214_18140	COG0328	RNA-DNA hybrid ribonuclease activity
HH214_18155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HH214_18165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HH214_18165	COG0784	Response regulator, receiver
HH214_18165	COG2205	protein histidine kinase activity
HH214_18165	COG2198	Histidine kinase
HH214_18210	COG1940	carbohydrate kinase activity
HH214_18220	COG3250	beta-galactosidase activity
HH214_18225	COG0363	glucosamine-6-phosphate deaminase activity
HH214_18240	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HH214_18255	COG3537	Alpha-1,2-mannosidase
HH214_18265	COG1472	Belongs to the glycosyl hydrolase 3 family
HH214_18275	COG1629	transport
HH214_18295	COG3250	beta-galactosidase activity
HH214_18300	COG1696	Membrane protein involved in D-alanine export
HH214_18315	COG4974	Belongs to the 'phage' integrase family
HH214_18350	COG0275	rRNA processing
HH214_18445	COG4974	Belongs to the 'phage' integrase family
HH214_18495	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HH214_18530	COG2205	protein histidine kinase activity
HH214_18580	COG2807	transmembrane transport
HH214_18590	COG1472	Belongs to the glycosyl hydrolase 3 family
HH214_18595	COG0531	amino acid
HH214_18605	COG2824	Alkylphosphonate utilization operon protein PhnA
HH214_18615	COG4771	TonB-dependent receptor
HH214_18620	COG0702	epimerase
HH214_18640	COG0612	Peptidase, M16
HH214_18670	COG0460	homoserine dehydrogenase
HH214_18670	COG0527	aspartate kinase activity
HH214_18685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HH214_18695	COG1193	negative regulation of DNA recombination
HH214_18705	COG2755	lipolytic protein G-D-S-L family
HH214_18705	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HH214_18715	COG0572	uridine kinase
HH214_18720	COG1388	LysM domain
HH214_18730	COG0783	Belongs to the Dps family
HH214_18745	COG0442	prolyl-tRNA aminoacylation
HH214_18750	COG0626	cystathionine gamma-synthase activity
HH214_18765	COG0596	Alpha beta hydrolase
HH214_18825	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_18830	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_18835	COG2373	Large extracellular alpha-helical protein
HH214_18840	COG4953	penicillin-binding protein 1C
HH214_18850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HH214_18875	COG0501	Belongs to the peptidase M48B family
HH214_18930	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HH214_18965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HH214_18980	COG0456	acetyltransferase
HH214_18985	COG0156	8-amino-7-oxononanoate synthase activity
HH214_19020	COG0436	Aminotransferase
HH214_19050	COG0789	Transcriptional regulator
HH214_19050	COG4978	Transcriptional regulator
HH214_19055	COG1181	Belongs to the D-alanine--D-alanine ligase family
HH214_19065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HH214_19070	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HH214_19075	COG1185	polyribonucleotide nucleotidyltransferase activity
HH214_19085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HH214_19090	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HH214_19095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HH214_19105	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HH214_19110	COG1132	(ABC) transporter
HH214_19120	COG1702	phosphate starvation-inducible protein PhoH
HH214_19125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HH214_19140	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HH214_19145	COG0860	N-Acetylmuramoyl-L-alanine amidase
HH214_19150	COG0860	N-Acetylmuramoyl-L-alanine amidase
HH214_19160	COG1546	Belongs to the CinA family
HH214_19160	COG1058	Belongs to the CinA family
HH214_19165	COG0508	dehydrogenase complex catalyzes the overall conversion of
HH214_19175	COG0463	Glycosyl transferase, family 2
HH214_19185	COG0460	homoserine dehydrogenase
HH214_19190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HH214_19195	COG2873	o-acetylhomoserine
HH214_19205	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HH214_19210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HH214_19215	COG0745	RESPONSE REGULATOR receiver
HH214_19225	COG0564	pseudouridine synthase activity
HH214_19235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HH214_19235	COG2207	Transcriptional regulator
HH214_19245	COG1166	arginine decarboxylase activity
HH214_19255	COG1999	signal sequence binding
HH214_19280	COG0019	diaminopimelate decarboxylase activity
HH214_19285	COG2723	6-phospho-beta-galactosidase activity
HH214_19305	COG0071	Belongs to the small heat shock protein (HSP20) family
HH214_19310	COG1666	GTP binding
HH214_19315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HH214_19325	COG0163	prenyltransferase activity
HH214_19335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HH214_19340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HH214_19350	COG0483	inositol monophosphate 1-phosphatase activity
HH214_19355	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HH214_19395	COG0700	Nucleoside recognition
HH214_19400	COG1765	OsmC-like protein
HH214_19410	COG2885	chlorophyll binding
HH214_19425	COG1584	GPR1 FUN34 yaaH family protein
HH214_19430	COG0588	phosphoglycerate mutase activity
HH214_19440	COG0527	aspartate kinase activity
HH214_19445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HH214_19450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HH214_19475	COG1472	Belongs to the glycosyl hydrolase 3 family
HH214_19485	COG0432	Pfam Uncharacterised protein family UPF0047
HH214_19490	COG2885	chlorophyll binding
HH214_19500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HH214_19500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HH214_19520	COG3387	PFAM Glycoside hydrolase 15-related
HH214_19525	COG0628	permease
HH214_19535	COG5002	protein histidine kinase activity
HH214_19545	COG0025	NhaP-type Na H and K H
HH214_19550	COG2814	Major facilitator Superfamily
HH214_19560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HH214_19565	COG1172	Belongs to the binding-protein-dependent transport system permease family
HH214_19570	COG1129	ABC transporter
HH214_19585	COG3958	Transketolase
HH214_19590	COG3959	Transketolase, thiamine diphosphate binding domain
HH214_19600	COG1595	DNA-templated transcription, initiation
HH214_19610	COG4771	TonB-dependent receptor
HH214_19615	COG0702	epimerase
HH214_19645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HH214_19665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HH214_19685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HH214_19700	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HH214_19705	COG1119	ATPase activity
HH214_19755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HH214_19760	COG0649	NAD binding
HH214_19765	COG0259	pyridoxamine-phosphate oxidase activity
HH214_19770	COG1678	Uncharacterized ACR, COG1678
HH214_19775	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HH214_19780	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HH214_19785	COG0473	3-isopropylmalate dehydrogenase activity
HH214_19795	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HH214_19800	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HH214_19805	COG2081	HI0933 family
HH214_19830	COG0667	Aldo Keto reductase
HH214_19860	COG0307	riboflavin synthase, alpha
HH214_19875	COG0443	Heat shock 70 kDa protein
HH214_19885	COG3142	Participates in the control of copper homeostasis
HH214_19890	COG1446	asparaginase
HH214_19900	COG0577	efflux transmembrane transporter activity
HH214_19905	COG0513	Belongs to the DEAD box helicase family
HH214_19930	COG0784	Response regulator, receiver
HH214_19930	COG2205	protein histidine kinase activity
HH214_19935	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HH214_19945	COG2205	protein histidine kinase activity
HH214_19945	COG0784	Response regulator, receiver
HH214_19950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HH214_19975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HH214_19990	COG1138	Cytochrome C-type biogenesis protein
HH214_20010	COG0633	Ferredoxin
HH214_20020	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HH214_20025	COG0424	maF-like protein
HH214_20030	COG0248	Ppx GppA phosphatase
HH214_20040	COG4152	abc transporter atp-binding protein
HH214_20045	COG0484	heat shock protein binding
HH214_20050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HH214_20055	COG2884	Cell division ATP-binding protein ftsE
HH214_20070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HH214_20075	COG0791	NLP P60 protein
HH214_20085	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HH214_20085	COG0140	phosphoribosyl-ATP diphosphatase activity
HH214_20090	COG0107	imidazoleglycerol-phosphate synthase activity
HH214_20095	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HH214_20105	COG0131	Imidazoleglycerol-phosphate dehydratase
HH214_20110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HH214_20115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HH214_20120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HH214_20130	COG0067	glutamate synthase
HH214_20130	COG0070	glutamate synthase
HH214_20130	COG0069	glutamate synthase activity
HH214_20160	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HH214_20165	COG0667	Aldo Keto reductase
HH214_20195	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HH214_20210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HH214_20220	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HH214_20225	COG0137	argininosuccinate synthase activity
HH214_20250	COG1956	GAF domain-containing protein
HH214_20260	COG2094	Belongs to the DNA glycosylase MPG family
HH214_20270	COG3844	kynureninase activity
HH214_20275	COG0123	including yeast histone deacetylase and acetoin utilization protein
HH214_20280	COG0534	Mate efflux family protein
HH214_20300	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HH214_20305	COG0463	Glycosyl transferase, family 2
HH214_20310	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_20330	COG1506	peptidase
HH214_20345	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HH214_20370	COG1090	epimerase
HH214_20380	COG1278	Cold shock
HH214_20395	COG0277	FAD linked oxidase domain protein
HH214_20395	COG0247	lactate metabolic process
HH214_20415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HH214_20425	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HH214_20445	COG1028	Short-chain dehydrogenase reductase Sdr
HH214_20450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HH214_20455	COG0584	glycerophosphoryl diester phosphodiesterase
HH214_20480	COG1295	ribonuclease BN
HH214_20505	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HH214_20515	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HH214_20540	COG0450	alkyl hydroperoxide reductase
HH214_20545	COG1278	Cold shock
HH214_20550	COG2814	Major facilitator Superfamily
HH214_20555	COG0408	coproporphyrinogen oxidase activity
HH214_20565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HH214_20590	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HH214_20595	COG1289	transmembrane transporter activity
HH214_20615	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HH214_20620	COG3119	arylsulfatase activity
HH214_20670	COG1764	response to oxidative stress
HH214_20675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HH214_20680	COG2239	Acts as a magnesium transporter
HH214_20690	COG1739	Uncharacterized protein family UPF0029
HH214_20695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HH214_20695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HH214_20700	COG2890	protein-(glutamine-N5) methyltransferase activity
HH214_20705	COG4974	Belongs to the 'phage' integrase family
HH214_20710	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HH214_20715	COG1196	nuclear chromosome segregation
HH214_20715	COG3264	Mechanosensitive ion channel
HH214_20735	COG0598	Magnesium transport protein CorA
HH214_20750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HH214_20760	COG0667	Aldo Keto reductase
HH214_20775	COG2010	Cytochrome c
HH214_20790	COG4120	Belongs to the binding-protein-dependent transport system permease family
HH214_20800	COG0436	Aminotransferase
HH214_20805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HH214_20810	COG3537	Alpha-1,2-mannosidase
HH214_20815	COG2326	polyphosphate kinase activity
HH214_20825	COG0823	Involved in the tonB-independent uptake of proteins
HH214_20835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HH214_20855	COG0156	8-amino-7-oxononanoate synthase activity
HH214_20860	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HH214_20870	COG4771	TonB-dependent receptor
HH214_20875	COG0018	arginyl-trna synthetase
HH214_20905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HH214_20920	COG2755	lipolytic protein G-D-S-L family
HH214_20920	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HH214_20935	COG0481	GTPase activity
HH214_20940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HH214_20955	COG0602	queuosine metabolic process
HH214_20965	COG0514	ATP-dependent DNA helicase (RecQ)
HH214_20980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HH214_20985	COG0305	Participates in initiation and elongation during chromosome replication
HH214_21005	COG2211	Major facilitator Superfamily
HH214_21010	COG1063	alcohol dehydrogenase
HH214_21015	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HH214_21030	COG1136	(ABC) transporter
HH214_21035	COG0577	efflux transmembrane transporter activity
HH214_21040	COG0577	efflux transmembrane transporter activity
HH214_21045	COG1136	(ABC) transporter
HH214_21045	COG0577	efflux transmembrane transporter activity
HH214_21050	COG0577	efflux transmembrane transporter activity
HH214_21070	COG1136	(ABC) transporter
HH214_21070	COG0577	efflux transmembrane transporter activity
HH214_21085	COG3852	Histidine kinase
HH214_21090	COG0326	Molecular chaperone. Has ATPase activity
HH214_21110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HH214_21120	COG0277	FAD linked oxidase domain protein
HH214_21120	COG0247	lactate metabolic process
HH214_21135	COG4181	ATPase activity
HH214_21140	COG0025	NhaP-type Na H and K H
HH214_21150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HH214_21155	COG2205	protein histidine kinase activity
HH214_21190	COG3278	Belongs to the heme-copper respiratory oxidase family
HH214_21215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HH214_21225	COG2205	protein histidine kinase activity
HH214_21225	COG5002	protein histidine kinase activity
HH214_21225	COG0784	Response regulator, receiver
HH214_21230	COG3781	membrane
HH214_21235	COG0058	SHG alpha-glucan phosphorylase activity
HH214_21255	COG3387	PFAM Glycoside hydrolase 15-related
HH214_21260	COG4251	negative regulation of phosphorylation
HH214_21280	COG3279	Response regulator of the LytR AlgR family
HH214_21285	COG0745	RESPONSE REGULATOR receiver
HH214_21285	COG2972	Histidine kinase
HH214_21315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HH214_21505	COG1484	DNA-dependent DNA replication
HH214_21510	COG4584	PFAM Integrase catalytic
HH214_21510	COG2390	Transcriptional regulator
HH214_21555	COG0739	heme binding
HH214_21665	COG2197	response regulator
HH214_21680	COG1192	Involved in chromosome partitioning
HH214_21730	COG1247	-acetyltransferase
HH214_21735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HH214_21745	COG0798	PFAM Bile acid sodium symporter
HH214_21760	COG2217	Heavy metal translocating P-type atpase
HH214_21780	COG2132	Multicopper oxidase
HH214_21825	COG2217	Heavy metal translocating P-type atpase
HH214_21875	COG2217	Heavy metal translocating P-type atpase