locus-tag class description Rv0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Rv0003 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Rv0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Rv0018c ENOG4108ZF3 Phosphatase Rv0020c ENOG4105TV9 FHA Domain-Containing protein Rv0021c ENOG4107QWG 2-Nitropropane dioxygenase Rv0037c ENOG4108M0D major facilitator superfamily Rv0044c ENOG4105DYW oxidoreductase Rv0046c ENOG4105CZA synthase Rv0048c ENOG41061MJ Domain of unknown function (DUF1707) Rv0050 ENOG4105BZ4 penicillin-binding protein Rv0058 ENOG4105CDU Replicative dna helicase Rv0062 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) Rv0063 ENOG4105DNP FAD linked oxidase domain protein Rv0064 ENOG4105DJZ UPF0182 protein Rv0067c ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Rv0068 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Rv0071 ENOG4105EKQ RNA-directed DNA polymerase Rv0074 ENOG4105CI2 imidazolone-5-propionate hydrolase Rv0075 ENOG4105C87 Aminotransferase class I and II Rv0078 ENOG4108Q5F Tetr family transcriptional regulator Rv0082 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit Rv0084 ENOG4107TDF Formate hydrogenlyase subunit 4 Rv0086 ENOG4108JPZ Monovalent cation H antiporter subunit D Rv0087 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Rv0101 ENOG4105CEY Amp-dependent synthetase and ligase Rv0103c ENOG4105C59 p-type ATPase Rv0107c ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Rv0111 ENOG4105EXC Acyl-transferase Rv0117 ENOG4105C5Q Transcriptional regulator Rv0118c ENOG4105CFN oxalyl-CoA decarboxylase Rv0120c ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Rv0127 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) Rv0134 ENOG4105D74 hydrolase Rv0143c ENOG4105CMQ Chloride channel Rv0144 ENOG4105PF9 Transcriptional regulator Rv0147 ENOG4105C26 Dehydrogenase Rv0148 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Rv0153c ENOG4105M2Z protein tyrosine serine phosphatase Rv0154c ENOG4105C1G acyl-Coa dehydrogenase Rv0155 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Rv0156 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Rv0157 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Rv0158 ENOG4108R86 Transcriptional regulator Rv0161 ENOG4105CQB FAD linked oxidase domain protein Rv0165c ENOG4108WYP Transcriptional regulator Rv0167 ENOG4105CY3 ABC transporter, permease Rv0183 ENOG4105E5G Alpha beta hydrolase fold Rv0190 ENOG4105VPX protein, conserved in bacteria Rv0191 ENOG4108XIC integral membrane protein Rv0192 ENOG4105S7A ErfK ybiS ycfS ynhG family protein Rv0194 ENOG4105BZ1 (ABC) transporter Rv0197 ENOG4107QY8 reductase Rv0198c ENOG4105C9K Endothelin-converting enzyme 1 Rv0206c ENOG4107R13 MMPL domain protein Rv0215c ENOG4105C1G acyl-Coa dehydrogenase Rv0218 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Rv0222 ENOG4105E39 Enoyl-CoA hydratase Rv0225 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Rv0233 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta Rv0236c ENOG41073B4 coagulation factor 5 8 type domain-containing protein Rv0237 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Rv0242c ENOG4105CHR reductase Rv0243 ENOG4105CHU acetyl-coa acetyltransferase Rv0244c ENOG4105CSU acyl-Coa dehydrogenase Rv0248c ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Rv0252 ENOG4107QZF nitrite reductase NADPH large subunit Rv0254c ENOG4108YZT Adenosylcobinamide kinase Rv0263c ENOG4107R7A Allophanate hydrolase subunit 2 Rv0267 ENOG4105DQQ Major facilitator superfamily MFS_1 Rv0268c ENOG4107CN4 Pfam:PhdYeFM Rv0270 ENOG4105CEY Amp-dependent synthetase and ligase Rv0271c ENOG4105D2B acyl-CoA dehydrogenase Rv0291 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin Rv0296c ENOG4105E0M Sulfatase Rv0300 ENOG4107DZG Ribbon-helix-helix protein, copG family Rv0306 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase Rv0308 ENOG4105YVM Phosphoesterase, PA-phosphatase related Rv0310c ENOG4105HMD Rv0322 ENOG4105C6Y Udp-glucose 6-dehydrogenase Rv0323c ENOG4105T1M mycothiol conjugate amidase mca Rv0324 ENOG41080HT Transcriptional regulator, arsr family Rv0326 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Rv0329c ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Rv0338c ENOG4105DF6 Fe-S oxidoreductase Rv0353 ENOG4105KNI merR family transcriptional Regulator Rv0359 ENOG4107XZ0 Peptidase M50 Rv0362 ENOG4105CJW magnesium transporter Rv0371c ENOG41085AN Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Rv0379 ENOG41084UG Pfam:DUF1458 Rv0389 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR Rv0392c ENOG4105CEP NADH dehydrogenase Rv0400c ENOG4105C1G acyl-Coa dehydrogenase Rv0405 ENOG4108JA1 polyketide synthase Rv0411c ENOG4105CT1 (ABC) transporter Rv0418 ENOG4105IIU Aminopeptidase Rv0425c ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Rv0436c ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase Rv0440 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Rv0447c ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Rv0469 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Rv0473 ENOG4106BRA Membrane Rv0505c ENOG4108RXW HAD-superfamily subfamily IB hydrolase Rv0511 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Rv0517 ENOG4105EXC Acyl-transferase Rv0522 ENOG4105C85 amino acid Rv0525 ENOG4108RH7 phosphoglycerate mutase Rv0527 ENOG4107QIV Cytochrome c biogenesis protein Rv0529 ENOG4105CRE cytochrome C Rv0535 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) Rv0536 ENOG4108IAJ Nad-dependent epimerase dehydratase Rv0545c ENOG4105CJ3 phosphate transporter Rv0547c ENOG4105PDP Short chain dehydrogenase Rv0551c ENOG4105CEY Amp-dependent synthetase and ligase Rv0552 ENOG4105CI2 imidazolone-5-propionate hydrolase Rv0565c ENOG4105CT3 Monooxygenase Rv0570 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Rv0582 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A Rv0584 ENOG4105CWX Alpha-1,2-mannosidase Rv0595c ENOG4107PBH Toxic component of a toxin-antitoxin (TA) module. A Rv0599c ENOG4106FRU abrb family transcriptional regulator Rv0602c ENOG4105ETX regulatoR Rv0613c ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Rv0620 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Rv0631c ENOG4105DSY exodeoxyribonuclease V, gamma Rv0634c ENOG4108151 Beta-lactamase domain protein Rv0636 ENOG4108F01 MaoC domain protein Rv0644c ENOG4108NUI synthase Rv0662c ENOG4107CD8 Rv0663 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) Rv0669c ENOG4107R72 Ceramidase Rv0672 ENOG4105CSU acyl-Coa dehydrogenase Rv0678 ENOG410600Z Regulatory protein MarR Rv0692 ENOG4105XDV Rv0697 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) Rv0711 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) Rv0712 ENOG4105E6M Sulphatase-modifying factor protein Rv0723 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Rv0724A ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) Rv0727c ENOG4107R0P L-ribulose-5-phosphate 4-epimerase Rv0728c ENOG4105C5I Dehydrogenase Rv0729 ENOG4105CMG Carbohydrate kinase Rv0731c ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) Rv0753c ENOG4105C26 Dehydrogenase Rv0754 ENOG4105GCF PGAM Rv0757 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Rv0758 ENOG4105BZU Histidine kinase Rv0765c ENOG4105CHR reductase Rv0773c ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Rv0777 ENOG4105C83 adenylosuccinate lyase Rv0783c ENOG4105C0R drug resistance transporter emrb qaca subfamily Rv0785 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein Rv0787A ENOG410839H phosphoribosylformylglycinamidine synthase Rv0791c ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Rv0792c ENOG4105CZE histidine utilization repressor Rv0793 ENOG41067V3 Antibiotic biosynthesis monooxygenase Rv0797 ENOG4107SVN transposase Rv0799c ENOG4105EZR dyp-type peroxidase family protein Rv0800 ENOG4105DFM M18 family aminopeptidase Rv0809 ENOG4105CXB phosphoribosylaminoimidazole synthetase Rv0811c ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Rv0814c ENOG4105PKJ carbohydrate binding Rv0818 ENOG4107NHD transcriptional regulator Rv0827c ENOG41082SX arsR family transcriptional regulator Rv0828c ENOG4108Z6B deaminase Rv0830 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) Rv0839 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) Rv0840c ENOG4107WD4 Releases the N-terminal proline from various substrates (By similarity) Rv0843 ENOG4108JYK Dehydrogenase Rv0846c ENOG4107R16 Multicopper oxidase Rv0848 ENOG410880H cysteine synthase Rv0859 ENOG4105CHU acetyl-coa acetyltransferase Rv0860 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Rv0865 ENOG4105EPU Molybdenum cofactor synthesis domain protein Rv0870c ENOG410901E Membrane Rv0871 ENOG4105VEQ Cold shock protein Rv0881 ENOG4105FCS tRNA rRNA methyltransferase Rv0885 ENOG4105URP P-aminobenzoate N-oxygenase AurF Rv0890c ENOG4105CQF Transcriptional regulator Rv0914c ENOG4105CHU acetyl-coa acetyltransferase Rv0930 ENOG4105E2Z phosphate ABC transporter (Permease Rv0938 ENOG4105DQE DNA ligase Rv0950c ENOG4105DR5 peptidase Rv0951 ENOG4105CMV Succinyl-CoA synthetase subunit beta Rv0958 ENOG4105C0P Mg chelatase subunit ChlI Rv0959 ENOG4107KWJ von Willebrand factor, type A Rv0966c ENOG41090WX Domain of unknown function (DUF1707) Rv0971c ENOG4105E39 Enoyl-CoA hydratase Rv0974c ENOG4107QX3 carboxylase Rv0981 ENOG4105ETX regulatoR Rv0982 ENOG41062D9 Histidine kinase Rv0984 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Rv0992c ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase Rv0993 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Rv0998 ENOG410870F Cyclic nucleotide-binding protein Rv1005c ENOG4105CRQ synthase (Component I) Rv1007c ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Rv1008 ENOG4105F8V Hydrolase, tatD family Rv1013 ENOG4107RCI amp-dependent synthetase and ligase Rv1019 ENOG4108IG5 Transcriptional regulator Rv1021 ENOG4105DXN mazG family Rv1028c ENOG4105C08 Histidine kinase Rv1032c ENOG4105BZU Histidine kinase Rv1033c ENOG4105CK6 Two component transcriptional regulator (Winged helix family Rv1043c ENOG4105C0H protease Rv1050 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Rv1058 ENOG4105CEY Amp-dependent synthetase and ligase Rv1074c ENOG4105CHU acetyl-coa acetyltransferase Rv1084 ENOG4105C7Z Conserved Protein Rv1093 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Rv1095 ENOG4108IAB Phoh family Rv1104 ENOG4105EBR Carboxylesterase Rv1112 ENOG4105C3G gtp-binding protein Rv1122 ENOG4108J5G 6-phosphogluconate dehydrogenase Rv1124 ENOG4108J2P Alpha beta hydrolase fold Rv1127c ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Rv1129c ENOG4105CFF transcriptional regulator Rv1130 ENOG4105DXD 2-methylcitrate dehydratase Rv1135A ENOG4105CHU acetyl-coa acetyltransferase Rv1141c ENOG4108UKI Enoyl-CoA hydratase Rv1142c ENOG4105E39 Enoyl-CoA hydratase Rv1143 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Rv1145 ENOG4107R13 MMPL domain protein Rv1146 ENOG4107R13 MMPL domain protein Rv1155 ENOG410905P Pyridoxamine 5-phosphate Rv1162 ENOG4108IUE nitrate reductase beta subunit Rv1175c ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Rv1177 ENOG4108Z4U Ferredoxin Rv1186c ENOG4108K8K Transcriptional regulator Rv1187 ENOG4105C26 Dehydrogenase Rv1188 ENOG41062BK proline dehydrogenase Rv1190 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) Rv1193 ENOG4105CEY Amp-dependent synthetase and ligase Rv1200 ENOG4105CSH Transporter Rv1205 ENOG4108URH decarboxylase Rv1210 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Rv1217c ENOG4105DIM ABC transporter Rv1218c ENOG4105CIG ABC transporter Rv1219c ENOG4108X07 Tetr family transcriptional regulator Rv1222 ENOG4106684 Rv1223 ENOG4105C0H protease Rv1232c ENOG4105CJW magnesium transporter Rv1239c ENOG4105D7N magnesium and cobalt transport protein CorA Rv1246c ENOG4105VG9 Plasmid stabilization system Rv1247c ENOG410684T prevent-host-death family Rv1257c ENOG4105CQB FAD linked oxidase domain protein Rv1266c ENOG4105D9P serine threonine protein kinase Rv1273c ENOG4105BZ1 (ABC) transporter Rv1290c ENOG4105EXU Membrane Rv1300 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Rv1319c ENOG4105F8J Adenylate Guanylate cyclase Rv1320c ENOG4105F8J Adenylate Guanylate cyclase Rv1321 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) Rv1326c ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Rv1328 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Rv1330c ENOG4107RKP Nicotinate phosphoribosyltransferase Rv1364c ENOG4108Q50 Histidine kinase Rv1373 ENOG4105DU4 Sulfotransferase Rv1377c ENOG4105DXX methyltransferase Rv1392 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Rv1393c ENOG4105F95 Monooxygenase Rv1426c ENOG4105EBR Carboxylesterase Rv1427c ENOG4105CEY Amp-dependent synthetase and ligase Rv1433 ENOG41069FZ L,D-transpeptidase catalytic domain Rv1442 ENOG4108J2R molybdopterin oxidoreductase Rv1448c ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Rv1449c ENOG4105CV1 Transketolase (EC 2.2.1.1) Rv1451 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Rv1454c ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Rv1459c ENOG4107JC6 Membrane Rv1462 ENOG4105JRK feS assembly protein SufD Rv1463 ENOG4105C3K feS assembly ATPase SufC Rv1465 ENOG4108UNV SUF system FeS assembly protein, NifU family Rv1466 ENOG4105VG1 fes assembly suf system protein Rv1467c ENOG4105C1G acyl-Coa dehydrogenase Rv1471 ENOG4105K63 Thioredoxin Rv1473 ENOG4105C5H ABC transporter Rv1474c ENOG4108Q5F Tetr family transcriptional regulator Rv1475c ENOG4107QM5 aconitate hydratase Rv1477 ENOG4105ZXU NLP P60 protein Rv1479 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Rv1486c ENOG4108UF8 Rv1498A ENOG4105WKW Pfam:DUF1458 Rv1498c ENOG4105G47 Methyltransferase, type 11 Rv1502 ENOG4108T5R Rv1503c ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Rv1504c ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Rv1508A ENOG4105C0K Gdp-mannose 4,6-dehydratase Rv1511 ENOG4105C0K Gdp-mannose 4,6-dehydratase Rv1512 ENOG4105C30 Nad-dependent epimerase dehydratase Rv1534 ENOG41067SE Tetr family transcriptional regulator Rv1544 ENOG4108W6C Dehydrogenase Rv1566c ENOG4105ZXU NLP P60 protein Rv1592c ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 Rv1602 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Rv1604 ENOG4108MWI inositol mono-phosphatase Rv1618 ENOG4105C29 acyl-CoA thioesterase Rv1619 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) Rv1620c ENOG4108JJ9 ABC, transporter Rv1621c ENOG4108JJ9 ABC, transporter Rv1622c ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Rv1623c ENOG4105C4M (Ubiquinol oxidase) subunit I Rv1637c ENOG4105C5X domain protein Rv1649 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Rv1661 ENOG4108JA1 polyketide synthase Rv1662 ENOG4108JA1 polyketide synthase Rv1664 ENOG4108JA1 polyketide synthase Rv1664 ENOG4108JA1 polyketide synthase Rv1667c ENOG4105C5H ABC transporter Rv1668c ENOG4105C5H ABC transporter Rv1674c ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) Rv1679 ENOG4105FDT acyl-CoA dehydrogenase Rv1680 ENOG4106ZX3 phosphonate ABC transporter, periplasmic phosphonate-binding protein Rv1684 ENOG4105W49 UPF0434 protein Rv1692 ENOG4105DSU hydrolase Rv1700 ENOG4108YZ4 nudix hydrolase Rv1703c ENOG4108VQJ O-methyltransferase Rv1704c ENOG4105C85 amino acid Rv1707 ENOG4105CHH sulfate transporter Rv1709 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Rv1710 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Rv1725c ENOG4107YPT transcriptional regulator Rv1733c ENOG41067QZ Membrane Rv1739c ENOG4107RBZ sulfate transporter Rv1747 ENOG4105IDI abc transporter atp-binding protein Rv1750c ENOG4105J5T Amp-dependent synthetase and ligase Rv1753c ENOG4105JWT ppe family Rv1766 ENOG4105XTG Pfam:DUF156 Rv1815 ENOG4106HTN secreted protease Rv1826 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Rv1832 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Rv1841c ENOG4107UAX integral membrane protein Rv1842c ENOG4105C37 (CBS) domain Rv1844c ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Rv1855c ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Rv1865c ENOG4105EMU Dehydrogenase Rv1867 ENOG4105CHU acetyl-coa acetyltransferase Rv1878 ENOG4105C5F glutamine synthetase Rv1882c ENOG4108IXY short-chain dehydrogenase reductase Rv1895 ENOG4105E2A Dehydrogenase Rv1899c ENOG4107Z0Z A1pp Rv1900c ENOG4105F8J Adenylate Guanylate cyclase Rv1903 ENOG41082T9 Membrane Rv1922 ENOG4105FQP Beta-lactamase Rv1928c ENOG4105H9W Short-chain dehydrogenase reductase Sdr Rv1933c ENOG4105D2B acyl-CoA dehydrogenase Rv1934c ENOG4105CC9 acyl-Coa dehydrogenase Rv1937 ENOG4105F57 Anthranilate dioxygenase reductase Rv1940 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Rv1941 ENOG4108R85 Short chain dehydrogenase Rv1942c ENOG4106USH transcriptional modulator of maze toxin, mazf Rv1944c ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Rv1990A ENOG41076PI Short-chain dehydrogenase reductase Sdr Rv2018 ENOG4105G3V Inherit from COG: Protein of unknown function (DUF433) Rv2019 ENOG4106G8I Rv2021c ENOG4106F59 XRE family Transcriptional regulator Rv2022c ENOG4105XUP Phage derived protein Gp49-like (DUF891) Rv2024c ENOG4108F3G Type I restriction-modification system, R subunit Rv2034 ENOG4105MHT Transcriptional regulator, ARSR family Rv2038c ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Rv2039c ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Rv2040c ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Rv2043c ENOG4108RWI nicotinamidase Rv2045c ENOG4105EBR Carboxylesterase Rv2059 ENOG4107XSR periplasmic solute binding protein Rv2062c ENOG4105CTK cobaltochelatase, cobn subunit Rv2067c ENOG4108XGZ Methyltransferase domain Rv2073c ENOG4108RG3 short-chain dehydrogenase reductase Rv2079 ENOG4105MPZ Pfam:DUF1023 Rv2090 ENOG4105HFS 5'-3' exonuclease Rv2101 ENOG4105C0D helicase Rv2102 ENOG4107XWB Zinc finger, swim domain protein Rv2103c ENOG4105RYD Toxic component of a toxin-antitoxin (TA) module. A Rv2109c ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) Rv2124c ENOG4105C3R Methionine synthase Rv2129c ENOG4108BAS reductase Rv2141c ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Rv2155c ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Rv2163c ENOG4105CJN penicillin-binding protein Rv2171 ENOG4105R14 (LipO)protein Rv2174 ENOG41090CE integral membrane protein Rv2175c ENOG4105KYH transcriptional regulatory protein Rv2178c ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase Rv2187 ENOG4108IQE Amp-dependent synthetase and ligase Rv2208 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) Rv2213 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Rv2226 ENOG4107DKM chad domain containing protein Rv2228c ENOG4105CVJ phosphoglycerate mutase Rv2236c ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) Rv2263 ENOG4105PDP Short chain dehydrogenase Rv2277c ENOG4106IDA glycerophosphoryl diester phosphodiesterase Rv2307c ENOG4107XR4 alpha beta Rv2308 ENOG4107P7U Inherit from COG: Protein of unknown function (DUF433) Rv2317 ENOG4105DRS transport system, permease Rv2320c ENOG4105CUB amino acid Rv2321c ENOG4105C8Y Acetylornithine aminotransferase Rv2322c ENOG4105C8Y Acetylornithine aminotransferase Rv2323c ENOG4105CIK Amidinotransferase Rv2324 ENOG4108VVK transcriptional Regulator, AsnC Rv2329c ENOG4105DQQ Major facilitator superfamily MFS_1 Rv2333c ENOG4105EDF drug resistance transporter, EmrB QacA subfamily Rv2335 ENOG4105D7W serine acetyltransferase Rv2338c ENOG4105CUZ uba thif-type nad fad binding protein Rv2377c ENOG4105WQT MbtH domain protein Rv2380c ENOG4105CEY Amp-dependent synthetase and ligase Rv2381c ENOG4107SQU synthase Rv2383c ENOG4105C0W non-ribosomal peptide synthetase Rv2384 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase Rv2395 ENOG4105EPD Oligopeptide transporter, Opt family Rv2398c ENOG4105ECW sulfate abc transporter Rv2399c ENOG4108I5D sulfate abc transporter Rv2400c ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Rv2402 ENOG4105BZP glycoside hydrolase 15-related Rv2407 ENOG4107XDQ Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Rv2415c ENOG4105KQC Competence protein Rv2418c ENOG4108TZC Rv2420c ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) Rv2421c ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Rv2426c ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Rv2430c ENOG4106EC3 ppe family Rv2434c ENOG4105D8X mechanosensitive ion channel Rv2435c ENOG4105BZU Histidine kinase Rv2436 ENOG4108RVA ribokinase Rv2439c ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Rv2443 ENOG4107QJT sodium dicarboxylate symporter Rv2444c ENOG4105C03 ribonuclease Rv2447c ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Rv2449c ENOG4105EG6 Saccharopine dehydrogenase Rv2454c ENOG4105DQU oxidoreductase, subunit beta Rv2455c ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein Rv2458 ENOG4107QK5 Homocysteine s-methyltransferase Rv2462c ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Rv2463 ENOG4108A04 Beta-lactamase Rv2466c ENOG4105MC2 DSBA oxidoreductase Rv2471 ENOG4105CG3 alpha amylase, catalytic region Rv2476c ENOG4105C7I Dehydrogenase Rv2494 ENOG4105GP6 Toxic component of a toxin-antitoxin (TA) module. A Rv2495c ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 Rv2499c ENOG4105DJG MaoC domain protein dehydratase Rv2500c ENOG4105C1G acyl-Coa dehydrogenase Rv2502c ENOG4107QX3 carboxylase Rv2505c ENOG4105CEY Amp-dependent synthetase and ligase Rv2509 ENOG4105E1F short-chain dehydrogenase reductase Rv2510c ENOG4105D7A ATP-binding protein Rv2525c ENOG4108WKN secreted protein Rv2528c ENOG4106H3A restriction Rv2533c ENOG410803B Involved in the transcription termination process (By similarity) Rv2553c ENOG4105HHA aminodeoxychorismate lyase Rv2555c ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Rv2556c ENOG4107ZED Uncharacterised protein family UPF0047 Rv2565 ENOG4107UFZ Cyclic nucleotide-binding protein Rv2567 ENOG4105NPQ Pfam:DUF403 Rv2584c ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Rv2585c ENOG4108NY6 Extracellular solute-binding protein, family 5 Rv2586c ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Rv2590 ENOG4105E4E Thioester reductase domain-containing protein Rv2605c ENOG4105C29 acyl-CoA thioesterase Rv2609c ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Rv2611c ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase Rv2616 ENOG4105PMW Domain of unknown function (DUF1990) Rv2642 ENOG41080HT Transcriptional regulator, arsr family Rv2646 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Rv2674 ENOG4105E0X reductase Rv2684 ENOG4108J9M Transporter Rv2688c ENOG4105U1W ABC transporter Rv2690c ENOG4105C0X amino acid Rv2691 ENOG4107VEG TrkA-N domain protein Rv2702 ENOG4105DFK Polyphosphate glucokinase Rv2720 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Rv2724c ENOG4105C1G acyl-Coa dehydrogenase Rv2725c ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Rv2731 ENOG4105C99 atpase involved in dna repair Rv2740 ENOG4105MXB limonene-12-epoxide hydrolase Rv2756c ENOG4105CVR type I restriction-modification system Rv2766c ENOG4105CHR reductase Rv2773c ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Rv2780 ENOG4105DCF alanine dehydrogenase Rv2781c ENOG4107QWG 2-Nitropropane dioxygenase Rv2782c ENOG4105C1V Peptidase, M16 Rv2789c ENOG4105C1G acyl-Coa dehydrogenase Rv2801c ENOG410839S Toxic component of a toxin-antitoxin (TA) module (By similarity) Rv2818c ENOG4108QA2 CRISPR-associated protein, Csm6 Rv2823c ENOG410695F Crispr-associated protein, Csm1 family Rv2829c ENOG41060JE PilT protein domain protein Rv2834c ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component Rv2837c ENOG4105SFS phosphoesterase RecJ domain protein Rv2847c ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Rv2849c ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Rv2856 ENOG4105D9G High-affinity Rv2859c ENOG4108Z86 Glutamine amidotransferase Rv2865 ENOG41067D0 Antitoxin component of a toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of toxin RelE2 Rv2866 ENOG4105VG9 Plasmid stabilization system Rv2874 ENOG4108HSG cytochrome biogenesis protein DipZ Rv2884 ENOG4107NHD transcriptional regulator Rv2897c ENOG4105C0P Mg chelatase subunit ChlI Rv2911 ENOG4105DZ1 carboxypeptidase Rv2917 ENOG4105F8X type iii restriction Rv2918c ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Rv2931 ENOG4107EEY synthase Rv2950c ENOG4107RCI amp-dependent synthetase and ligase Rv2958c ENOG4105DHH glycosyltransferase MGT family Rv2963 ENOG4108M4U conserved membrane protein Rv2966c ENOG4106H78 methyltransferase Rv2967c ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) Rv2970A ENOG4105CV8 reductase Rv2974c ENOG4105DP4 dak2 domain fusion protein ylov Rv2981c ENOG4105CPF Cell wall formation (By similarity) Rv2982c ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Rv2988c ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Rv2993c ENOG4105ERH Fumarylacetoacetate hydrolase Rv2994 ENOG4105E5T Major Facilitator Superfamily Rv2995c ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Rv3000 ENOG4105C4B ABC transporter, permease Rv3005c ENOG4108VGI doxx family Rv3011c ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Rv3034c ENOG4105EVB acetyltransferase Rv3035 ENOG4108V0V Pyrrolo-quinoline quinone Rv3041c ENOG4105DKW ABC transporter Rv3042c ENOG4105EAC phosphoserine phosphatase Rv3049c ENOG4107RN6 Monooxygenase Rv3050c ENOG4105EJ2 Transcriptional regulator Rv3060c ENOG4107YCY Transcriptional regulator Rv3061c ENOG4105D2B acyl-CoA dehydrogenase Rv3062 ENOG4107QIM DNA ligase Rv3063 ENOG4105D22 carbon starvation protein Rv3079c ENOG4105FBW Monooxygenase Rv3092c ENOG4105CKW Inner membrane protein yedI Rv3095 ENOG4107YPT transcriptional regulator Rv3101c ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) Rv3102c ENOG4105CAK Cell division ATP-binding protein ftsE Rv3107c ENOG4105CQB FAD linked oxidase domain protein Rv3110 ENOG41090A4 Pterin carbinolamine dehydratase Rv3112 ENOG41067WU Molybdopterin converting factor (Subunit 1) Rv3118 ENOG4105PKJ carbohydrate binding Rv3121 ENOG4106P4H Cytochrome P450 Rv3130c ENOG4107S4F acyltransferase, ws dgat mgat Rv3137 ENOG4107TK4 histidinol-phosphate phosphatase Rv3140 ENOG4105C1G acyl-Coa dehydrogenase Rv3151 ENOG4108IEH NADH dehydrogenase subunit g Rv3154 ENOG4105DF2 NADH dehydrogenase subunit j Rv3164c ENOG4105C7R Atpase associated with various cellular activities aaa_3 Rv3173c ENOG4108JGH Tetr family transcriptional regulator Rv3175 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Rv3182 ENOG4105XUP Phage derived protein Gp49-like (DUF891) Rv3183 ENOG4106F59 XRE family Transcriptional regulator Rv3191c ENOG4105F9F transposase Rv3197A ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Rv3199c ENOG4105E09 nadh pyrophosphatase Rv3201c ENOG4105C4R Atp-dependent dna helicase Rv3203 ENOG4108YIQ Alpha beta hydrolase Rv3204 ENOG41080UX Methyltransferase Rv3211 ENOG4105C1J atp-dependent rna helicase Rv3214 ENOG4108ZM9 phosphoglycerate mutase Rv3218 ENOG4105CBD Diacylglycerol kinase Rv3224 ENOG4105CHR reductase Rv3224B ENOG4108Z66 YbaK ebsC protein Rv3226c ENOG4108RAV Conserved protein Rv3228 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Rv3232c ENOG4105CSR polyphosphate kinase 2 Rv3236c ENOG4105CKD glutathione-regulated potassium-efflux system protein Rv3238c ENOG4108SVW integral membrane protein Rv3241c ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea Rv3245c ENOG4105BZU Histidine kinase Rv3250c ENOG4105VCQ rubredoxin Rv3251c ENOG41084UD rubredoxin Rv3252c ENOG4105EEF Alkane 1-monooxygenase Rv3253c ENOG4105CUB amino acid Rv3255c ENOG4105EIP mannose-6-phosphate isomerase Rv3257c ENOG4107QKV phosphomannomutase Rv3260c ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Rv3267 ENOG4107TB5 TRANSCRIPTIONal Rv3272 ENOG410846T CoA-transferase family III Rv3273 ENOG4105CHH sulfate transporter Rv3280 ENOG4105D8K carboxyl transferase Rv3285 ENOG4108JIK carboxylase Rv3293 ENOG4105C26 Dehydrogenase Rv3296 ENOG4107QRT dEAD DEAH box helicase Rv3300c ENOG4105D3G Pseudouridine synthase Rv3305c ENOG4107RM1 amidohydrolase Rv3308 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain Rv3310 ENOG4105FBN Acid phosphatase Rv3319 ENOG4105E33 succinate dehydrogenase Rv3327 ENOG4107SVN transposase Rv3328c ENOG4108KPJ rna polymerase sigma factor Rv3329 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Rv3330 ENOG4105DZ1 carboxypeptidase Rv3331 ENOG4105C54 Major Facilitator superfamily Rv3332 ENOG4105CE4 GlcNAc 6-P deacetylase Rv3334 ENOG4108Z6Z Transcriptional regulator Rv3335c ENOG4107H3J ribonuclease Rv3340 ENOG4108IQK o-acetylhomoserine Rv3352c ENOG4105DNP FAD linked oxidase domain protein Rv3356c ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Rv3359 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Rv3360 ENOG4105IDI abc transporter atp-binding protein Rv3361c ENOG4107Z6C Pentapeptide repeat-containing protein Rv3364c ENOG4105GWZ Roadblock lc7 family protein Rv3366 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Rv3373 ENOG4105E39 Enoyl-CoA hydratase Rv3377c ENOG4107R2E Inherit from NOG: halimadienyl-diphosphate synthase activity Rv3379c ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Rv3384c ENOG4105YXB Toxic component of a toxin-antitoxin (TA) module. A Rv3390 ENOG4105GCF PGAM Rv3408 ENOG4105YXB Toxic component of a toxin-antitoxin (TA) module. A Rv3420c ENOG41080E2 ribosomal-protein-alanine acetyltransferase Rv3427c ENOG4105F5W AtP-binding protein Rv3428c ENOG4106IJN integrase catalytic domain-containing protein Rv3432c ENOG4105CVK Glutamate decarboxylase Rv3447c ENOG4105EC2 ftsk spoIIIe Rv3449 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin Rv3459c ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Rv3469c ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) Rv3470c ENOG4106WR0 acetolactate synthase (large subunit) Rv3476c ENOG4105CSH Transporter Rv3480c ENOG4105D8T Acyltransferase Rv3484 ENOG4107TB5 TRANSCRIPTIONal Rv3486 ENOG4105NQG DoxX Rv3488 ENOG4105VUN Transcriptional regulator Rv3490 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase Rv3502c ENOG4105CHR reductase Rv3504 ENOG4105X7H acyl-CoA dehydrogenase Rv3505 ENOG4108KC2 acyl-Coa dehydrogenase Rv3516 ENOG4105E39 Enoyl-CoA hydratase Rv3520c ENOG4105DYW oxidoreductase Rv3522 ENOG4105CHU acetyl-coa acetyltransferase Rv3523 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Rv3525c ENOG4108Z0R Transferase Rv3526 ENOG4105CIJ rieske 2fe-2S domain-containing protein Rv3530c ENOG4105CHR reductase Rv3537 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein Rv3542c ENOG410900P UPF0336 protein Rv3543c ENOG4105X7H acyl-CoA dehydrogenase Rv3544c ENOG4108RK3 acyl-Coa dehydrogenase Rv3546 ENOG4105F2C Acetyl-CoA acetyltransferase Rv3548c ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Rv3550 ENOG4105E39 Enoyl-CoA hydratase Rv3553 ENOG4105EA8 2-Nitropropane dioxygenase Rv3554 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Rv3556c ENOG4105F2C Acetyl-CoA acetyltransferase Rv3560c ENOG4105CC9 acyl-Coa dehydrogenase Rv3561 ENOG4105CEY Amp-dependent synthetase and ligase Rv3562 ENOG4105CC9 acyl-Coa dehydrogenase Rv3563 ENOG4105D2B acyl-CoA dehydrogenase Rv3564 ENOG4105D2B acyl-CoA dehydrogenase Rv3565 ENOG4105CHM Aminotransferase Rv3573c ENOG4105D2B acyl-CoA dehydrogenase Rv3574 ENOG4108SGK Tetr family transcriptional regulator Rv3596c ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Rv3617 ENOG4105D74 hydrolase Rv3627c ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase Rv3630 ENOG4108XUD Membrane Rv3641c ENOG4105MZU cell filamentation protein Rv3644c ENOG4107QRG dna polymerase iii Rv3649 ENOG4108I5C dEAD DEAH box helicase Rv3663c ENOG4108JQ6 ABC transporter Rv3664c ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Rv3665c ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Rv3672c ENOG4105P8F nudix hydrolase Rv3677c ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Rv3683 ENOG4105DIN metallophosphoesterase Rv3684 ENOG4105C6T cysteine synthase Rv3691 ENOG4108WQ6 secreted protein Rv3692 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Rv3696c ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Rv3702c ENOG4108V75 Glutamine amidotransferase Rv3703c ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process Rv3707c ENOG4108NJC Rv3712 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Rv3717 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase Rv3720 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Rv3722c ENOG4105XT2 Transcriptional regulator Rv3725 ENOG4105CMR udp-glucose 4-epimerase Rv3726 ENOG4105CPQ Dehydrogenase Rv3729 ENOG4105DVA methyltransferase Rv3730c ENOG4105DQE DNA ligase Rv3742c ENOG4105CT3 Monooxygenase Rv3744 ENOG41066UM arsR family transcriptional regulator Rv3750c ENOG4105VT3 DNA binding domain protein, excisionase family Rv3752c ENOG4108Z6B deaminase Rv3754 ENOG4105EVN Prephenate dehydrogenase Rv3757c ENOG4105E90 ABC transporter Rv3758c ENOG4108IJ8 ABC transporter Rv3760 ENOG41060H3 Protein of unknown function (DUF1049) Rv3762c ENOG4105EUZ Beta-lactamase domain protein Rv3764c ENOG4105BZU Histidine kinase Rv3765c ENOG4105CK6 Two component transcriptional regulator (Winged helix family Rv3772 ENOG4105CIH Imidazole acetol-phosphate transaminase Rv3784 ENOG4105C1B dTDP-glucose 4-6-dehydratase Rv3793 ENOG4105J1Z Arabinosyltransferase Rv3796 ENOG4107XDQ Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Rv3797 ENOG4105C1G acyl-Coa dehydrogenase Rv3799c ENOG4105D8K carboxyl transferase Rv3801c ENOG4107RCI amp-dependent synthetase and ligase Rv3805c ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids Rv3808c ENOG410602S Transferase Rv3813c ENOG4108X4Q Hydrolase Rv3816c ENOG4105E9Q Acyl-transferase Rv3832c ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Rv3840 ENOG4108KGH TRANSCRIPTIONal Rv3856c ENOG4105DCG PHP domain protein Rv3859c ENOG4105CBC glutamate synthase Rv3866 ENOG4106BSN growth Rv3884c ENOG4106F1P AAA ATPase, central domain protein Rv3915 ENOG4108E1C hydrolase Rv3918c ENOG4107QJE Chromosome Partitioning Protein