locus-tag class description A3N97_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) A3N97_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A3N97_00015 ENOG4108J5G 6-phosphogluconate dehydrogenase A3N97_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) A3N97_00025 ENOG4105K7N UPF0232 protein A3N97_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A3N97_00115 ENOG4105EQ0 Major Facilitator superfamily A3N97_00120 ENOG4106NZI LysR family Transcriptional regulator A3N97_00135 ENOG4107ZXI Rhomboid family A3N97_00140 ENOG4106N8J Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) A3N97_00155 ENOG4105XBB septation inhibitor protein A3N97_00170 ENOG4105D9P serine threonine protein kinase A3N97_00175 ENOG4107TPY serine threonine protein kinase A3N97_00180 ENOG4105CJN penicillin-binding protein A3N97_00195 ENOG4105HZM Fha domain containing protein A3N97_00200 ENOG4105TV9 FHA Domain-Containing protein A3N97_00215 ENOG4106032 Glutathionylspermidine synthase A3N97_00225 ENOG4107MVR Transcriptional regulator A3N97_00245 ENOG4106V5Y EsaT-6 like protein A3N97_00265 ENOG4107Y2X deaminase A3N97_00270 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) A3N97_00275 ENOG4105DND Transcriptional regulator A3N97_00280 ENOG4105CQ7 ATP-dependent helicase A3N97_00285 ENOG41061TZ Short-chain dehydrogenase reductase Sdr A3N97_00315 ENOG4105C1G acyl-Coa dehydrogenase A3N97_00360 ENOG4107S2E monooxygenase A3N97_00370 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase A3N97_00375 ENOG4107258 Transcriptional regulator A3N97_00395 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein A3N97_00425 ENOG4105G6Z alkaline phosphatase A3N97_00445 ENOG4105CBC glutamate synthase A3N97_00475 ENOG4105DCG PHP domain protein A3N97_00485 ENOG4105F95 Monooxygenase A3N97_00495 ENOG4106A3M Cytochrome p-450 A3N97_00520 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A3N97_00525 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) A3N97_00535 ENOG4105FXM Copper resistance protein A3N97_00585 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) A3N97_00590 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) A3N97_00600 ENOG4105BZU Histidine kinase A3N97_00605 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) A3N97_00610 ENOG4107YEV ferritin A3N97_00615 ENOG4107YEV ferritin A3N97_00620 ENOG4108KGH TRANSCRIPTIONal A3N97_00645 ENOG4105CQC Prephenate dehydratase A3N97_00650 ENOG4105GCF PGAM A3N97_00655 ENOG4105C7K acetolactate synthase A3N97_00665 ENOG4105F95 Monooxygenase A3N97_00675 ENOG4105F95 Monooxygenase A3N97_00695 ENOG4105KT7 mgtC SapB transporter A3N97_00730 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) A3N97_00745 ENOG4107B57 rieske 2fe-2S domain-containing protein A3N97_00755 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) A3N97_00760 ENOG4105EA8 2-Nitropropane dioxygenase A3N97_00765 ENOG41090U3 tautomerase A3N97_00785 ENOG4105CHR reductase A3N97_00790 ENOG4105PSQ Acyl-transferase A3N97_00820 ENOG410602S Transferase A3N97_00830 ENOG4106YN8 Prenyltransferase A3N97_00835 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids A3N97_00860 ENOG4107RCI amp-dependent synthetase and ligase A3N97_00870 ENOG4105D8K carboxyl transferase A3N97_00880 ENOG4105PGM cation diffusion facilitator family transporter A3N97_00890 ENOG4105J1Z Arabinosyltransferase A3N97_00910 ENOG4105J1Z Arabinosyltransferase A3N97_00920 ENOG4108RG3 short-chain dehydrogenase reductase A3N97_00925 ENOG4105IQ5 FAD linked oxidase domain protein A3N97_00940 ENOG4105CMT Dihydroxyacetone kinase A3N97_00950 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A3N97_00955 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) A3N97_00970 ENOG4105YVM Phosphoesterase, PA-phosphatase related A3N97_00980 ENOG4108MKI Glycosyl transferase, family 2 A3N97_00990 ENOG4108VC7 Protein of unknown function (DUF2587) A3N97_01075 ENOG4105C9B Cysteine desulfurase A3N97_01090 ENOG4105CIH Imidazole acetol-phosphate transaminase A3N97_01150 ENOG4105C1G acyl-Coa dehydrogenase A3N97_01165 ENOG4105CHR reductase A3N97_01185 ENOG4105E90 ABC transporter A3N97_01190 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component A3N97_01200 ENOG4105EVN Prephenate dehydrogenase A3N97_01210 ENOG4108Z6B deaminase A3N97_01235 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) A3N97_01245 ENOG4105DRP amino acid AbC transporter A3N97_01255 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) A3N97_01265 ENOG4105DQE DNA ligase A3N97_01295 ENOG4105CIS alcohol dehydrogenase A3N97_01320 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase A3N97_01335 ENOG4105EBR Carboxylesterase A3N97_01345 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase A3N97_01375 ENOG4105XT2 Transcriptional regulator A3N97_01400 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase A3N97_01410 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) A3N97_01440 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase A3N97_01450 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) A3N97_01455 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) A3N97_01460 ENOG4105DFU Cell wall formation (By similarity) A3N97_01480 ENOG4105C1G acyl-Coa dehydrogenase A3N97_01495 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) A3N97_01500 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) A3N97_01505 ENOG4105W0E 50S ribosomal protein L33 A3N97_01520 ENOG4105NRA 50s ribosomal protein l31 type b A3N97_01525 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) A3N97_01550 ENOG4105CFH Aspartokinase A3N97_01555 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) A3N97_01565 ENOG4108NJC A3N97_01570 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) A3N97_01580 ENOG4105F2Z 3-oxoadipate enol-lactonase A3N97_01590 ENOG4105CH6 catalase A3N97_01645 ENOG4105CE4 GlcNAc 6-P deacetylase A3N97_01650 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) A3N97_01655 ENOG4105RD7 BadF BadG BcrA BcrD A3N97_01660 ENOG4107QNK )-transporter A3N97_01680 ENOG4105D1K glutamate--cysteine ligase A3N97_01685 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process A3N97_01690 ENOG4108V75 Glutamine amidotransferase A3N97_01695 ENOG41067HS methyltransferase A3N97_01725 ENOG4105CHU acetyl-coa acetyltransferase A3N97_01730 ENOG410900P UPF0336 protein A3N97_01735 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr A3N97_01740 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) A3N97_01750 ENOG4105NTW Transcriptional regulator A3N97_01780 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A3N97_01785 ENOG4108WQ6 secreted protein A3N97_01820 ENOG4105C7H Helicase, RecD TraA family A3N97_01825 ENOG4107QKA exodeoxyribonuclease V beta A3N97_01830 ENOG4105DSY exodeoxyribonuclease V, gamma A3N97_01875 ENOG4105DIN metallophosphoesterase A3N97_01880 ENOG4108JQC penicillin-binding protein 1A A3N97_01885 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) A3N97_01910 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) A3N97_01950 ENOG4108XEP Alpha Beta Hydrolase Fold protein A3N97_01965 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A3N97_01970 ENOG4105DEF Extracellular solute-binding protein, family 5 A3N97_01980 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A3N97_02070 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A3N97_02075 ENOG4108I5C dEAD DEAH box helicase A3N97_02080 ENOG4105VEQ Cold shock protein A3N97_02090 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) A3N97_02170 ENOG4108PBI Polysaccharide metabolism A3N97_02205 ENOG4107RN6 Monooxygenase A3N97_02235 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family A3N97_02250 ENOG4108UGV hypoxanthine phosphoribosyltransferase A3N97_02265 ENOG4105CPQ Dehydrogenase A3N97_02275 ENOG4105D74 hydrolase A3N97_02285 ENOG4105MKU Transcriptional regulator A3N97_02305 ENOG4105EUJ GTP cyclohydrolase i A3N97_02340 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) A3N97_02345 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) A3N97_02350 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) A3N97_02355 ENOG4105CRK lysyL-tRNA synthetase A3N97_02365 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit A3N97_02375 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) A3N97_02380 ENOG4105EHG Permease protein A3N97_02405 ENOG41082A2 Alpha beta hydrolase A3N97_02410 ENOG4105HSS phospholipase C A3N97_02425 ENOG4105CEN a g-specific adenine glycosylase A3N97_02435 ENOG4107TB5 TRANSCRIPTIONal A3N97_02445 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) A3N97_02455 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) A3N97_02475 ENOG4108VJ1 Transcriptional regulator (CarD family A3N97_02480 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) A3N97_02485 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) A3N97_02490 ENOG4105C8N cysteinyl-tRNA synthetase A3N97_02495 ENOG4105C2N RNA methyltransferase TrmH family group 3 A3N97_02500 ENOG4108QXE glycerophosphoryl diester phosphodiesterase A3N97_02510 ENOG4105CC5 ABC transporter A3N97_02515 ENOG4105E0A ABC, transporter A3N97_02520 ENOG4107XSR periplasmic solute binding protein A3N97_02530 ENOG4108SGK Tetr family transcriptional regulator A3N97_02535 ENOG4105D2B acyl-CoA dehydrogenase A3N97_02550 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) A3N97_02560 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase A3N97_02570 ENOG4107SCA Formamidase (EC 3.5.1.49) A3N97_02580 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) A3N97_02600 ENOG4105D2B acyl-CoA dehydrogenase A3N97_02605 ENOG4105D2B acyl-CoA dehydrogenase A3N97_02610 ENOG4105CC9 acyl-Coa dehydrogenase A3N97_02615 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_02620 ENOG4105CC9 acyl-Coa dehydrogenase A3N97_02635 ENOG4105F2C Acetyl-CoA acetyltransferase A3N97_02650 ENOG4105EA8 2-Nitropropane dioxygenase A3N97_02665 ENOG4105E39 Enoyl-CoA hydratase A3N97_02670 ENOG4105K6S Short-chain dehydrogenase reductase Sdr A3N97_02675 ENOG4105CHR reductase A3N97_02695 ENOG4105F2C Acetyl-CoA acetyltransferase A3N97_02705 ENOG4108RK3 acyl-Coa dehydrogenase A3N97_02710 ENOG4105X7H acyl-CoA dehydrogenase A3N97_02715 ENOG410900P UPF0336 protein A3N97_02745 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein A3N97_02760 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) A3N97_02765 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) A3N97_02800 ENOG4108JPZ Monovalent cation H antiporter subunit D A3N97_02810 ENOG4105D65 subunit l A3N97_02825 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme A3N97_02835 ENOG4105D4U had-superfamily hydrolase, subfamily iia A3N97_02870 ENOG4105PDP Short chain dehydrogenase A3N97_02905 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A3N97_02955 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_02970 ENOG4106V5Y EsaT-6 like protein A3N97_03010 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3N97_03015 ENOG4105BZU Histidine kinase A3N97_03020 ENOG4107ZUX Histidine triad (HIT) protein A3N97_03025 ENOG4108594 Permease of the drug metabolite transporter A3N97_03035 ENOG4105D74 hydrolase A3N97_03065 ENOG4105CHM Aminotransferase A3N97_03075 ENOG4105C83 adenylosuccinate lyase A3N97_03085 ENOG4105C8V SAICAR synthetase A3N97_03095 ENOG4108R85 Short chain dehydrogenase A3N97_03115 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein A3N97_03125 ENOG410839H phosphoribosylformylglycinamidine synthase A3N97_03140 ENOG4105EZR dyp-type peroxidase family protein A3N97_03145 ENOG4105DFM M18 family aminopeptidase A3N97_03165 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii A3N97_03190 ENOG4107P26 A3N97_03220 ENOG4105C1B dTDP-glucose 4-6-dehydratase A3N97_03230 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A3N97_03235 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A3N97_03270 ENOG4105CXB phosphoribosylaminoimidazole synthetase A3N97_03280 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) A3N97_03290 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands A3N97_03320 ENOG4105ECQ AraC Family Transcriptional Regulator A3N97_03325 ENOG4105PKJ carbohydrate binding A3N97_03330 ENOG4105KHC sulfurtransferase A3N97_03350 ENOG4107NHD transcriptional regulator A3N97_03355 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) A3N97_03360 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) A3N97_03370 ENOG4105E2Z phosphate ABC transporter (Permease A3N97_03375 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) A3N97_03380 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein A3N97_03460 ENOG4108Q5Y Membrane A3N97_03480 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) A3N97_03485 ENOG4105D2S major facilitator superfamily A3N97_03490 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A3N97_03530 ENOG4105M03 Domain of unknown function (DUF955) A3N97_03645 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A3N97_03845 ENOG4107R08 Integrase A3N97_03865 ENOG4105FDP GntR family transcriptional regulator A3N97_03905 ENOG4105C0D helicase A3N97_03990 ENOG4108JPW Aminotransferase A3N97_03995 ENOG4105C1G acyl-Coa dehydrogenase A3N97_04000 ENOG4105C26 Dehydrogenase A3N97_04005 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F A3N97_04020 ENOG4105F6U Short-chain dehydrogenase reductase Sdr A3N97_04050 ENOG4105E39 Enoyl-CoA hydratase A3N97_04095 ENOG410846T CoA-transferase family III A3N97_04120 ENOG4105CHU acetyl-coa acetyltransferase A3N97_04170 ENOG4105CFI type iii restriction protein res subunit A3N97_04210 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A3N97_04225 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A3N97_04230 ENOG4105VEQ Cold shock protein A3N97_04270 ENOG4107SFI Major Facilitator superfamily A3N97_04345 ENOG4108ZHJ Organic hydroperoxide resistance protein A3N97_04350 ENOG4105K56 Transcriptional regulator A3N97_04355 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) A3N97_04360 ENOG4105EDW glycosyl transferase, family 39 A3N97_04360 ENOG4105EDW glycosyl transferase, family 39 A3N97_04365 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) A3N97_04370 ENOG4105URP P-aminobenzoate N-oxygenase AurF A3N97_04390 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) A3N97_04400 ENOG4107RCI amp-dependent synthetase and ligase A3N97_04425 ENOG4105E8G Major facilitator Superfamily A3N97_04460 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone A3N97_04470 ENOG4108JPW Aminotransferase A3N97_04480 ENOG4105KKJ Aminoglycoside phosphotransferase A3N97_04485 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr A3N97_04490 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A3N97_04495 ENOG41081K0 peptidylprolyl cis-trans isomerase A3N97_04515 ENOG4105H3G oxidoreductase A3N97_04535 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic A3N97_04585 ENOG4105C26 Dehydrogenase A3N97_04600 ENOG4107XFJ UPF0246 protein A3N97_04610 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) A3N97_04645 ENOG41060BG Tetr family transcriptional regulator A3N97_04675 ENOG4105K89 arsenate reductase A3N97_04680 ENOG4108W5M transcriptional regulator A3N97_04720 ENOG4105CHU acetyl-coa acetyltransferase A3N97_04780 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) A3N97_04805 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) A3N97_04890 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 A3N97_04915 ENOG4105CPC Aldo Keto reductase A3N97_04965 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) A3N97_04975 ENOG4105K56 Transcriptional regulator A3N97_05030 ENOG4105CSR polyphosphate kinase 2 A3N97_05045 ENOG4105CKI cobalamin synthesis protein A3N97_05050 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A3N97_05055 ENOG4108S8N class II Aldolase A3N97_05065 ENOG4107QP8 phosphohexose isomerase A3N97_05090 ENOG4105CMV Succinyl-CoA synthetase subunit beta A3N97_05110 ENOG4105FBW Monooxygenase A3N97_05165 ENOG4107QX3 carboxylase A3N97_05185 ENOG4105ETX regulatoR A3N97_05195 ENOG4105C0H protease A3N97_05200 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A3N97_05230 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase A3N97_05235 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase A3N97_05330 ENOG4105CEU Arginine dihydrolase A3N97_05345 ENOG4105CRQ synthase (Component I) A3N97_05370 ENOG4105F8V Hydrolase, tatD family A3N97_05375 ENOG4106839 domain protein A3N97_05380 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) A3N97_05390 ENOG4105D9P serine threonine protein kinase A3N97_05410 ENOG410645S MarR family Transcriptional regulator A3N97_05420 ENOG4107RCI amp-dependent synthetase and ligase A3N97_05425 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) A3N97_05430 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) A3N97_05435 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) A3N97_05460 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) A3N97_05470 ENOG4108RZE Tetr family transcriptional regulator A3N97_05515 ENOG4105DXN mazG family A3N97_05520 ENOG4105EKT )-iron permease A3N97_05530 ENOG4105DBE peroxidase A3N97_05535 ENOG410650H (LipO)protein A3N97_05550 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) A3N97_05570 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) A3N97_05605 ENOG4105CYC Transferase A3N97_05665 ENOG4108ZT1 Transcriptional regulator A3N97_05680 ENOG4105E39 Enoyl-CoA hydratase A3N97_05690 ENOG4105C26 Dehydrogenase A3N97_05700 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR A3N97_05705 ENOG4105CHU acetyl-coa acetyltransferase A3N97_05725 ENOG4105W8D rdd domain containing protein A3N97_05740 ENOG4105C7B Threonine dehydratase A3N97_05750 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) A3N97_05760 ENOG4105T1M mycothiol conjugate amidase mca A3N97_05770 ENOG4105C7Z Conserved Protein A3N97_05790 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) A3N97_05795 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr A3N97_05800 ENOG4106A3M Cytochrome p-450 A3N97_05820 ENOG4105H9W Short-chain dehydrogenase reductase Sdr A3N97_05860 ENOG4105EBR Carboxylesterase A3N97_05870 ENOG4105E90 ABC transporter A3N97_05875 ENOG4108IJ8 ABC transporter A3N97_05880 ENOG4105E90 ABC transporter A3N97_05885 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system A3N97_05915 ENOG4105CS9 pantothenic acid kinase A3N97_05925 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) A3N97_05935 ENOG4108IAB Phoh family A3N97_05940 ENOG4107VMI polysaccharide deacetylase A3N97_06010 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) A3N97_06020 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) A3N97_06035 ENOG4105D22 carbon starvation protein A3N97_06060 ENOG4105K78 MarR family Transcriptional regulator A3N97_06065 ENOG4105C3G gtp-binding protein A3N97_06075 ENOG4107R16 Multicopper oxidase A3N97_06085 ENOG410880H cysteine synthase A3N97_06095 ENOG4105C5H ABC transporter A3N97_06165 ENOG4107R13 MMPL domain protein A3N97_06200 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) A3N97_06250 ENOG4108U8T Mannosyltransferase A3N97_06265 ENOG410842T Pterin carbinolamine dehydratase A3N97_06285 ENOG4105EUZ Beta-lactamase domain protein A3N97_06305 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) A3N97_06345 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A3N97_06355 ENOG4108Z4U Ferredoxin A3N97_06365 ENOG4105EDW glycosyl transferase, family 39 A3N97_06370 ENOG4105C26 Dehydrogenase A3N97_06375 ENOG41062BK proline dehydrogenase A3N97_06380 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_06405 ENOG4105R1U AraC Family Transcriptional Regulator A3N97_06420 ENOG4108URH decarboxylase A3N97_06450 ENOG4105C3Q Glycosyl transferase, family 2 A3N97_06465 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) A3N97_06475 ENOG4107QPH glycogen) synthase A3N97_06480 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) A3N97_06490 ENOG4105DIM ABC transporter A3N97_06495 ENOG4105CIG ABC transporter A3N97_06500 ENOG4108X07 Tetr family transcriptional regulator A3N97_06505 ENOG4107ZBN O-methyltransferase A3N97_06510 ENOG4105DU6 RNA polymerase A3N97_06515 ENOG4106684 A3N97_06520 ENOG4105C0H protease A3N97_06590 ENOG4105D7N magnesium and cobalt transport protein CorA A3N97_06595 ENOG41076UM multiple antibiotic resistance (MarC)-related protein A3N97_06635 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR A3N97_06640 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 A3N97_06645 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 A3N97_06655 ENOG4105C2C drug resistance transporter, Bcr CflA A3N97_06710 ENOG4105CQB FAD linked oxidase domain protein A3N97_06715 ENOG41076PI Short-chain dehydrogenase reductase Sdr A3N97_06730 ENOG4105D8X mechanosensitive ion channel A3N97_06750 ENOG4105BZ1 (ABC) transporter A3N97_06785 ENOG4107T8P acyl-Coa dehydrogenase A3N97_06795 ENOG4105EJ2 Transcriptional regulator A3N97_06820 ENOG4105F27 Major Facilitator A3N97_06845 ENOG4105C75 arginyL-tRNA synthetase A3N97_06850 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) A3N97_06855 ENOG4105D6E homoserine dehydrogenase A3N97_06860 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) A3N97_06865 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) A3N97_06890 ENOG4105VFB Binds the 23S rRNA (By similarity) A3N97_06895 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) A3N97_06900 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) A3N97_06910 ENOG4105ESV Glycosyl transferase, family 4 A3N97_06915 ENOG4105YV6 ATP synthase i A3N97_06920 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) A3N97_06925 ENOG410679R F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) A3N97_06930 ENOG4105V1A F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) A3N97_06935 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) A3N97_06940 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) A3N97_06945 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) A3N97_06950 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) A3N97_06970 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) A3N97_06995 ENOG4105F8J Adenylate Guanylate cyclase A3N97_07000 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) A3N97_07015 ENOG4105CHU acetyl-coa acetyltransferase A3N97_07020 ENOG4105EYF MMPL domain protein A3N97_07035 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) A3N97_07040 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) A3N97_07045 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) A3N97_07060 ENOG4108RWI nicotinamidase A3N97_07070 ENOG4107RKP Nicotinate phosphoribosyltransferase A3N97_07085 ENOG4105KXX peptidase s58 dmpa A3N97_07120 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) A3N97_07125 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) A3N97_07130 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein A3N97_07150 ENOG4107RCI amp-dependent synthetase and ligase A3N97_07165 ENOG4105EYH Exonuclease A3N97_07170 ENOG4106YT9 Enoyl-CoA hydratase A3N97_07180 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) A3N97_07185 ENOG4107SCK Monooxygenase A3N97_07195 ENOG41080U6 GntR family transcriptional regulator A3N97_07210 ENOG4108KAZ Involved in phosphonate degradation (By similarity) A3N97_07220 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3N97_07255 ENOG4108YIQ Alpha beta hydrolase A3N97_07260 ENOG4108WKN secreted protein A3N97_07275 ENOG4108Z4K mutator MutT protein A3N97_07295 ENOG4108X07 Tetr family transcriptional regulator A3N97_07310 ENOG4105ENE Histidine kinase A3N97_07315 ENOG4105WH1 Two component transcriptional regulator luxr family A3N97_07325 ENOG4105CJW magnesium transporter A3N97_07335 ENOG4108IXY short-chain dehydrogenase reductase A3N97_07345 ENOG4105CV8 reductase A3N97_07380 ENOG4105D7A ATP-binding protein A3N97_07395 ENOG4105E1F short-chain dehydrogenase reductase A3N97_07410 ENOG4107QJT sodium dicarboxylate symporter A3N97_07420 ENOG4105C0X amino acid A3N97_07445 ENOG41061MV Arylsulfatase A3N97_07485 ENOG410870F Cyclic nucleotide-binding protein A3N97_07520 ENOG4105C7I Dehydrogenase A3N97_07540 ENOG4105CG3 alpha amylase, catalytic region A3N97_07575 ENOG4105MC2 DSBA oxidoreductase A3N97_07595 ENOG4105MKU Transcriptional regulator A3N97_07625 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation A3N97_07630 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A3N97_07635 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A3N97_07640 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) A3N97_07670 ENOG4105EJ2 Transcriptional regulator A3N97_07690 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) A3N97_07700 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein A3N97_07705 ENOG4105DQU oxidoreductase, subunit beta A3N97_07745 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) A3N97_07750 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase A3N97_07760 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) A3N97_07765 ENOG4105C03 ribonuclease A3N97_07765 ENOG4105C03 ribonuclease A3N97_07770 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) A3N97_07775 ENOG4105K46 50S ribosomal protein l27 A3N97_07780 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control A3N97_07785 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) A3N97_07805 ENOG4108RVA ribokinase A3N97_07810 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) A3N97_07825 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) A3N97_07835 ENOG4105CVJ phosphoglycerate mutase A3N97_07840 ENOG4108TZC A3N97_07890 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) A3N97_07920 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) A3N97_07935 ENOG4105BZP glycoside hydrolase 15-related A3N97_07950 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) A3N97_07980 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein A3N97_07985 ENOG4107Z6A sulfate abc transporter permease A3N97_08040 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) A3N97_08045 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) A3N97_08060 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) A3N97_08075 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) A3N97_08090 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) A3N97_08095 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) A3N97_08140 ENOG4105DY8 decarboxylase A3N97_08175 ENOG4107RCI amp-dependent synthetase and ligase A3N97_08225 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) A3N97_08230 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A3N97_08235 ENOG4105K6H D-cysteine desulfhydrase A3N97_08255 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) A3N97_08315 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component A3N97_08330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3N97_08335 ENOG4105BZU Histidine kinase A3N97_08350 ENOG4105DB4 A3N97_08410 ENOG4105BZU Histidine kinase A3N97_08450 ENOG4105D4Y metalloprotease A3N97_08470 ENOG4105C1G acyl-Coa dehydrogenase A3N97_08475 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) A3N97_08530 ENOG4105C1G acyl-Coa dehydrogenase A3N97_08535 ENOG4105CHU acetyl-coa acetyltransferase A3N97_08545 ENOG4105KDM Diguanylate cyclase with gaf sensor A3N97_08550 ENOG4105CI2 imidazolone-5-propionate hydrolase A3N97_08595 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) A3N97_08600 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase A3N97_08625 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) A3N97_08670 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F A3N97_08715 ENOG4105D9G High-affinity A3N97_08720 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) A3N97_08755 ENOG4105CVJ phosphoglycerate mutase A3N97_08820 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) A3N97_08840 ENOG4105C5F glutamine synthetase A3N97_08845 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) A3N97_08875 ENOG4108TAG Histidine kinase A3N97_08925 ENOG4105C5F glutamine synthetase A3N97_08970 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) A3N97_08975 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) A3N97_08990 ENOG41063C6 UPF0235 protein A3N97_09010 ENOG4105CM2 brancheD-chain amino acid aminotransferase A3N97_09020 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) A3N97_09025 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) A3N97_09070 ENOG4108ZRS Part of cytochrome c oxidase, its function is A3N97_09105 ENOG4105CCU oxidase (Subunit III) A3N97_09110 ENOG4108I0Q anthranilate phosphoribosyltransferase A3N97_09145 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) A3N97_09170 ENOG4105D0U Arsenite-activated ATPase (ArsA) A3N97_09180 ENOG4105PSQ Acyl-transferase A3N97_09185 ENOG4108VJY integral membrane protein A3N97_09195 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase A3N97_09210 ENOG4105KYH transcriptional regulatory protein A3N97_09215 ENOG41090CE integral membrane protein A3N97_09230 ENOG4105R14 (LipO)protein A3N97_09245 ENOG4108V6E Cell division protein mraZ A3N97_09250 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) A3N97_09260 ENOG4105CJN penicillin-binding protein A3N97_09275 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) A3N97_09280 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) A3N97_09290 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) A3N97_09295 ENOG4105DFU Cell wall formation (By similarity) A3N97_09300 ENOG4105ME9 cell division protein FtsQ A3N97_09320 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) A3N97_09330 ENOG4105NPE arsR family transcriptional regulator A3N97_09380 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) A3N97_09390 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) A3N97_09400 ENOG4105CHR reductase A3N97_09430 ENOG4105D94 Major Facilitator Superfamily A3N97_09495 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) A3N97_09505 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone A3N97_09510 ENOG410900P UPF0336 protein A3N97_09530 ENOG4106YT9 Enoyl-CoA hydratase A3N97_09565 ENOG4107QX3 carboxylase A3N97_09595 ENOG4107RN6 Monooxygenase A3N97_09600 ENOG4107RN6 Monooxygenase A3N97_09610 ENOG4105F95 Monooxygenase A3N97_09625 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_09630 ENOG4105C1G acyl-Coa dehydrogenase A3N97_09650 ENOG4105C1G acyl-Coa dehydrogenase A3N97_09740 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) A3N97_09750 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) A3N97_09800 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) A3N97_09805 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo A3N97_09810 ENOG4105C8N cysteinyl-tRNA synthetase A3N97_09815 ENOG4108BAS reductase A3N97_09825 ENOG4107SQU synthase A3N97_09830 ENOG4107EEY synthase A3N97_09840 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_09850 ENOG4105C0W non-ribosomal peptide synthetase A3N97_09860 ENOG4105DMF Dehydrogenase A3N97_09865 ENOG4105EN6 Membrane A3N97_09880 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 A3N97_09885 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase A3N97_09890 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) A3N97_09905 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A3N97_09910 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain A3N97_09915 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A3N97_09925 ENOG4107QIZ NADH dehydrogenase A3N97_09930 ENOG4108IEH NADH dehydrogenase subunit g A3N97_09935 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) A3N97_09940 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A3N97_09945 ENOG4105DF2 NADH dehydrogenase subunit j A3N97_09950 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A3N97_09965 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A3N97_09980 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) A3N97_10030 ENOG4105C1J atp-dependent rna helicase A3N97_10055 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) A3N97_10070 ENOG4105C7K acetolactate synthase A3N97_10085 ENOG4105CIH Imidazole acetol-phosphate transaminase A3N97_10095 ENOG4105E5F proteasome A3N97_10100 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) A3N97_10105 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) A3N97_10110 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) A3N97_10125 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component A3N97_10130 ENOG4106FTQ Taurine ABC transporter, periplasmic A3N97_10135 ENOG4108IY8 ABC, transporter A3N97_10140 ENOG4107S1E Beta-lactamase A3N97_10160 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) A3N97_10175 ENOG4107TMB Transcriptional regulator A3N97_10180 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) A3N97_10215 ENOG4108RG3 short-chain dehydrogenase reductase A3N97_10250 ENOG4105CTK cobaltochelatase, cobn subunit A3N97_10270 ENOG4105EFZ amidohydrolase A3N97_10280 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) A3N97_10290 ENOG4105Q70 A3N97_10330 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component A3N97_10340 ENOG4105GVF (ABC) transporter A3N97_10345 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) A3N97_10365 ENOG4105KAV tspo and mbr like protein A3N97_10370 ENOG4106VYT conserved transmembrane protein A3N97_10375 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin A3N97_10390 ENOG4106V5Y EsaT-6 like protein A3N97_10420 ENOG4106F1P AAA ATPase, central domain protein A3N97_10435 ENOG41061H0 Monooxygenase A3N97_10440 ENOG4105DND Transcriptional regulator A3N97_10470 ENOG4108IYU L-aspartate oxidase A3N97_10480 ENOG4108Z6Z Transcriptional regulator A3N97_10485 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase A3N97_10515 ENOG4105JQZ Methyltransferase A3N97_10535 ENOG4105EV8 ectoine hydroxylase A3N97_10540 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) A3N97_10545 ENOG4108JPW Aminotransferase A3N97_10550 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase A3N97_10570 ENOG4105DBE peroxidase A3N97_10580 ENOG4105JXH GntR family transcriptional regulator A3N97_10585 ENOG4105DJ2 Major Facilitator Superfamily A3N97_10595 ENOG4107R13 MMPL domain protein A3N97_10640 ENOG4107T3I fad-binding protein A3N97_10645 ENOG4107RWR Sodium hydrogen exchanger A3N97_10705 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) A3N97_10760 ENOG4108Z4X TRANSCRIPTIONal A3N97_10795 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_10810 ENOG4105CRK lysyL-tRNA synthetase A3N97_10825 ENOG41084BS 50S ribosomal protein L35 A3N97_10830 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) A3N97_10880 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) A3N97_10885 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) A3N97_10890 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase A3N97_10895 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) A3N97_10900 ENOG4105CAS nag kinase A3N97_10905 ENOG4105C8Y Acetylornithine aminotransferase A3N97_10910 ENOG4105DBV ornithine carbamoyltransferase A3N97_10915 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) A3N97_10920 ENOG4105CDH Citrulline--aspartate ligase A3N97_10925 ENOG4105CH7 arginosuccinase A3N97_10960 ENOG4105W49 UPF0434 protein A3N97_10970 ENOG4108VX5 3-methyladenine DNA glycosylase A3N97_10995 ENOG4105DSU hydrolase A3N97_11010 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) A3N97_11030 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) A3N97_11055 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) A3N97_11070 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) A3N97_11100 ENOG4108R0M Aminoglycoside A3N97_11120 ENOG4107EFR Flavocytochrome c A3N97_11150 ENOG4105C1G acyl-Coa dehydrogenase A3N97_11180 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) A3N97_11205 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor A3N97_11215 ENOG4107QP3 malate synthase g A3N97_11220 ENOG4107UAX integral membrane protein A3N97_11225 ENOG4105C37 (CBS) domain A3N97_11235 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) A3N97_11285 ENOG4108YZ9 Urea amidohydrolase subunit gamma A3N97_11295 ENOG4105CQM Urea amidohydrolase subunit alpha A3N97_11300 ENOG4108ZJ1 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) A3N97_11305 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) A3N97_11315 ENOG4105CEP NADH dehydrogenase A3N97_11325 ENOG4105DYW oxidoreductase A3N97_11360 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) A3N97_11370 ENOG41083TI Protein CrcB homolog A3N97_11385 ENOG4105CEV competence damage-inducible protein A3N97_11395 ENOG4105ECQ AraC Family Transcriptional Regulator A3N97_11400 ENOG4105EUB pirin domain protein A3N97_11420 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) A3N97_11425 ENOG4108SEA Esterase A3N97_11450 ENOG4105DNP FAD linked oxidase domain protein A3N97_11460 ENOG4105J7D transcriptional regulator A3N97_11475 ENOG4108IJ6 ABC transporter A3N97_11480 ENOG4105I5W Transporter A3N97_11520 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) A3N97_11540 ENOG4105ZXU NLP P60 protein A3N97_11555 ENOG4107RN6 Monooxygenase A3N97_11575 ENOG4105CSH Transporter A3N97_11595 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) A3N97_11600 ENOG4105CBC glutamate synthase A3N97_11630 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) A3N97_11645 ENOG4105CC9 acyl-Coa dehydrogenase A3N97_11660 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB A3N97_11665 ENOG4105CPT Alpha beta hydrolase A3N97_11685 ENOG4105CJP fad dependent oxidoreductase A3N97_11695 ENOG4107QRI Phosphoketolase A3N97_11715 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) A3N97_11810 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase A3N97_11815 ENOG4105DKP glycosyl transferase, family 9 A3N97_11820 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) A3N97_11825 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) A3N97_11830 ENOG4106517 Short-chain dehydrogenase reductase Sdr A3N97_11840 ENOG4105C6Y Udp-glucose 6-dehydrogenase A3N97_11845 ENOG4105CXN decarboxylase A3N97_11875 ENOG4105CH6 catalase A3N97_11895 ENOG4105C85 amino acid A3N97_11910 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_11930 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) A3N97_11935 ENOG4105DWY Agmatine deiminase A3N97_11950 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A3N97_12000 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) A3N97_12025 ENOG4108V9Q carbonic anhydrase A3N97_12095 ENOG4107QRI Phosphoketolase A3N97_12195 ENOG4105EYF MMPL domain protein A3N97_12215 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_12240 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) A3N97_12265 ENOG41088PD hydrolase A3N97_12295 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) A3N97_12335 ENOG410905P Pyridoxamine 5-phosphate A3N97_12355 ENOG41082SX arsR family transcriptional regulator A3N97_12375 ENOG4108RZE Tetr family transcriptional regulator A3N97_12380 ENOG4105H3G oxidoreductase A3N97_12390 ENOG4105J5T Amp-dependent synthetase and ligase A3N97_12400 ENOG4105TRI Hydrolase A3N97_12420 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) A3N97_12455 ENOG4108IV0 ABC, transporter A3N97_12460 ENOG4105C0Z ABC transporter A3N97_12465 ENOG4105CF8 branched-chain amino acid ABC transporter, permease A3N97_12470 ENOG4105C32 Amino acid ABC transporter (Permease) A3N97_12495 ENOG4105HMD A3N97_12500 ENOG4105C4M (Ubiquinol oxidase) subunit I A3N97_12505 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii A3N97_12510 ENOG4108JJ9 ABC, transporter A3N97_12515 ENOG4108JJ8 (ABC) transporter A3N97_12540 ENOG4105C29 acyl-CoA thioesterase A3N97_12550 ENOG4105KPY Small multidrug resistance protein A3N97_12560 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) A3N97_12565 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) A3N97_12575 ENOG4105DK0 Indole-3-glycerol phosphate synthase A3N97_12585 ENOG4105CRQ synthase (Component I) A3N97_12590 ENOG4105GVJ transcriptional regulator A3N97_12615 ENOG4105CT3 Monooxygenase A3N97_12670 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) A3N97_12675 ENOG4108MWI inositol mono-phosphatase A3N97_12680 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase A3N97_12685 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) A3N97_12690 ENOG4105ECC imidazole-glycerol-phosphate dehydratase A3N97_12695 ENOG4105CIH Imidazole acetol-phosphate transaminase A3N97_12720 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) A3N97_12735 ENOG4108RZE Tetr family transcriptional regulator A3N97_12755 ENOG4107YNJ LysR family Transcriptional regulator A3N97_12760 ENOG4105DWT malate dehydrogenase (quinone) A3N97_12770 ENOG41066NP positive regulation by symbiont of host immune response A3N97_12775 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) A3N97_12785 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) A3N97_12790 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) A3N97_12800 ENOG4105EXC Acyl-transferase A3N97_12845 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) A3N97_12860 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) A3N97_12865 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) A3N97_12870 ENOG4105D94 Major Facilitator Superfamily A3N97_12875 ENOG4108M0I Transcriptional regulator A3N97_12920 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) A3N97_12925 ENOG4105CJW magnesium transporter A3N97_12950 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) A3N97_12955 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH A3N97_12965 ENOG4107QVM von Willebrand factor, type A A3N97_12975 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A3N97_12985 ENOG4105ZXU NLP P60 protein A3N97_12995 ENOG4107QM5 aconitate hydratase A3N97_13000 ENOG4108Q5F Tetr family transcriptional regulator A3N97_13025 ENOG4105C5H ABC transporter A3N97_13040 ENOG41080RH Thioredoxin A3N97_13055 ENOG4108XET gCN5-related N-acetyltransferase A3N97_13065 ENOG4105VG1 fes assembly suf system protein A3N97_13070 ENOG4108UNV SUF system FeS assembly protein, NifU family A3N97_13080 ENOG4105C3K feS assembly ATPase SufC A3N97_13100 ENOG4107JC6 Membrane A3N97_13125 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) A3N97_13150 ENOG4105CY3 ABC transporter, permease A3N97_13200 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein A3N97_13205 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) A3N97_13215 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) A3N97_13265 ENOG4105CP7 Triose-phosphate isomerase A3N97_13275 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase A3N97_13285 ENOG4105CIE May be required for sporulation (By similarity) A3N97_13295 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) A3N97_13300 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) A3N97_13325 ENOG4107FQ9 ethanolamine ammonia-lyase A3N97_13330 ENOG4105CPD ethanolamine ammonia-lyase A3N97_13335 ENOG4105CUB amino acid A3N97_13345 ENOG4107RR1 TRANSCRIPTIONal A3N97_13355 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) A3N97_13360 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) A3N97_13390 ENOG4108UMI ABC transporter, permease A3N97_13395 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) A3N97_13400 ENOG4105D01 (LipO)protein A3N97_13405 ENOG4106HTN secreted protease A3N97_13410 ENOG41064B9 (LipO)protein A3N97_13415 ENOG4107UWP Major facilitator superfamily MFS_1 A3N97_13435 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) A3N97_13455 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease A3N97_13465 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) A3N97_13470 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) A3N97_13480 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP A3N97_13490 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) A3N97_13510 ENOG4105SKN orotidine 5''-phosphate decarboxylase A3N97_13515 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain A3N97_13520 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain A3N97_13535 ENOG4105CXT aspartate transcarbamylase A3N97_13540 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) A3N97_13560 ENOG410803B Involved in the transcription termination process (By similarity) A3N97_13565 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) A3N97_13570 ENOG4105DC7 peptidase M24 A3N97_13580 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) A3N97_13585 ENOG4105D49 3-dehydroquinate synthase A3N97_13590 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) A3N97_13595 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase A3N97_13605 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) A3N97_13615 ENOG4105URP P-aminobenzoate N-oxygenase AurF A3N97_13620 ENOG4105E2X shikimate dehydrogenase A3N97_13630 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) A3N97_13635 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A3N97_13700 ENOG4108PJD permease A3N97_13720 ENOG4105C9M aspartyl-trna synthetase A3N97_13725 ENOG4105EBR Carboxylesterase A3N97_13755 ENOG4105CUT histidyl-tRNA synthetase A3N97_13765 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) A3N97_13775 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) A3N97_13780 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) A3N97_13785 ENOG4108NY6 Extracellular solute-binding protein, family 5 A3N97_13790 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) A3N97_13805 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) A3N97_13810 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) A3N97_13815 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) A3N97_13835 ENOG4105CDY transcriptional regulatory protein A3N97_13845 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) A3N97_13850 ENOG4105C29 acyl-CoA thioesterase A3N97_13855 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) A3N97_13865 ENOG4105E2K Glycosyl transferase (Group 1 A3N97_13875 ENOG4108VTU Cdp-alcohol phosphatidyltransferase A3N97_13885 ENOG4105C22 threonyL-tRNA synthetase A3N97_13890 ENOG4105ECQ AraC Family Transcriptional Regulator A3N97_13905 ENOG4105PMW Domain of unknown function (DUF1990) A3N97_13940 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) A3N97_13945 ENOG4105KME endoribonuclease L-psp A3N97_13960 ENOG4105BZU Histidine kinase A3N97_14015 ENOG4108KDT Molybdate metabolism regulator A3N97_14020 ENOG4105KKX ATPase associated with various cellular activities aaa_5 A3N97_14025 ENOG4105RD5 A3N97_14030 ENOG4105DEG Vwa containing coxe family protein A3N97_14035 ENOG410903U zinc ion binding A3N97_14085 ENOG4105C7W Xanthine dehydrogenase A3N97_14095 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) A3N97_14100 ENOG4107QUY Guanine deaminase A3N97_14120 ENOG4105C2W permease A3N97_14140 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease A3N97_14170 ENOG4105D74 hydrolase A3N97_14185 ENOG4105D0M Protease HtpX homolog A3N97_14200 ENOG4105C57 major facilitator superfamily A3N97_14215 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) A3N97_14250 ENOG4105EJ2 Transcriptional regulator A3N97_14265 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase A3N97_14300 ENOG4108P2G integral membrane protein A3N97_14305 ENOG4105E0X reductase A3N97_14325 ENOG4107JTW chlorite dismutase A3N97_14330 ENOG4105C1Q protoporphyrinogen oxidase A3N97_14335 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) A3N97_14345 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) A3N97_14355 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) A3N97_14360 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) A3N97_14365 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) A3N97_14370 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A3N97_14375 ENOG4105C0X amino acid A3N97_14380 ENOG4107VEG TrkA-N domain protein A3N97_14425 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) A3N97_14470 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A3N97_14480 ENOG4107QN2 dihydrolipoyl dehydrogenase A3N97_14520 ENOG4105E18 UPF0276 protein A3N97_14590 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) A3N97_14600 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) A3N97_14610 ENOG4105C1G acyl-Coa dehydrogenase A3N97_14615 ENOG4108J2R molybdopterin oxidoreductase A3N97_14620 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) A3N97_14625 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) A3N97_14630 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) A3N97_14640 ENOG4105C99 atpase involved in dna repair A3N97_14650 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A3N97_14660 ENOG4105CDA abc transporter atp-binding protein A3N97_14665 ENOG4107UBR Extracellular solute-binding protein family 3 A3N97_14670 ENOG4108Q1T ABC transporter A3N97_14675 ENOG4105DRP amino acid AbC transporter A3N97_14705 ENOG4105KC9 Modulates RecA activity (By similarity) A3N97_14710 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) A3N97_14725 ENOG4105MXB limonene-12-epoxide hydrolase A3N97_14730 ENOG4105MXB limonene-12-epoxide hydrolase A3N97_14750 ENOG4105WBV Transcriptional regulator A3N97_14760 ENOG4105CHR reductase A3N97_14825 ENOG4105CN5 Metallo-Beta-Lactamase A3N97_14830 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A3N97_14835 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) A3N97_14845 ENOG4105T0Z Conserved Protein A3N97_14860 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) A3N97_14895 ENOG4105CHH sulfate transporter A3N97_14905 ENOG4105DCF alanine dehydrogenase A3N97_14915 ENOG4107RN6 Monooxygenase A3N97_14930 ENOG4105C1V Peptidase, M16 A3N97_14935 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) A3N97_14945 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) A3N97_14965 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) A3N97_14995 ENOG4105D2B acyl-CoA dehydrogenase A3N97_15000 ENOG4105D2B acyl-CoA dehydrogenase A3N97_15005 ENOG4105E39 Enoyl-CoA hydratase A3N97_15030 ENOG4105SFS phosphoesterase RecJ domain protein A3N97_15035 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) A3N97_15040 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) A3N97_15055 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) A3N97_15060 ENOG41081JD Transcriptional regulator A3N97_15090 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) A3N97_15105 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A3N97_15190 ENOG4105DWT malate dehydrogenase (quinone) A3N97_15210 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) A3N97_15245 ENOG4105DZP Membrane-associated zinc metalloprotease A3N97_15270 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs A3N97_15280 ENOG4108JU3 Alkyl hydroperoxide reductase A3N97_15310 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) A3N97_15330 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) A3N97_15335 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) A3N97_15340 ENOG4105EEM helicase A3N97_15345 ENOG4106Z1T Nicotinamide Mononucleotide Transporter A3N97_15360 ENOG410630P Transcriptional regulator A3N97_15370 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) A3N97_15375 ENOG4105CE9 30S ribosomal protein S2 A3N97_15390 ENOG4107MVR Transcriptional regulator A3N97_15410 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A3N97_15430 ENOG4105DND Transcriptional regulator A3N97_15455 ENOG4105C0P Mg chelatase subunit ChlI A3N97_15500 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) A3N97_15510 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) A3N97_15520 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) A3N97_15525 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) A3N97_15535 ENOG4105K5M 30s ribosomal protein S16 A3N97_15580 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) A3N97_15600 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) A3N97_15650 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) A3N97_15655 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) A3N97_15660 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) A3N97_15670 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) A3N97_15675 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) A3N97_15685 ENOG41087HT growth A3N97_15690 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) A3N97_15730 ENOG4106H78 methyltransferase A3N97_15735 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) A3N97_15755 ENOG4105DYW oxidoreductase A3N97_15775 ENOG41068W2 Cytochrome p-450 A3N97_15790 ENOG4105CB5 ATP-dependent DNA helicase recG A3N97_15795 ENOG4105DP4 dak2 domain fusion protein ylov A3N97_15805 ENOG4105E39 Enoyl-CoA hydratase A3N97_15815 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) A3N97_15830 ENOG4105CPF Cell wall formation (By similarity) A3N97_15835 ENOG4105C28 cystathionine A3N97_15840 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase A3N97_15845 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) A3N97_15850 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) A3N97_15865 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A3N97_15870 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A3N97_15900 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) A3N97_15905 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase A3N97_15920 ENOG4105E5T Major Facilitator Superfamily A3N97_15925 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A3N97_15950 ENOG4105EGI Transcriptional regulator A3N97_15960 ENOG4108RCM Nitroreductase A3N97_15975 ENOG4108RZE Tetr family transcriptional regulator A3N97_15990 ENOG4106A3M Cytochrome p-450 A3N97_16015 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase A3N97_16020 ENOG4108ZP8 Acetolactate synthase small subunit A3N97_16035 ENOG4105E3Q saccharopine dehydrogenase A3N97_16040 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A3N97_16080 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) A3N97_16090 ENOG4105EBR Carboxylesterase A3N97_16105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3N97_16110 ENOG4105EB3 Histidine kinase A3N97_16120 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A3N97_16125 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) A3N97_16135 ENOG4105EDW glycosyl transferase, family 39 A3N97_16140 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) A3N97_16150 ENOG4106HTN secreted protease A3N97_16160 ENOG4106HTN secreted protease A3N97_16165 ENOG4105E39 Enoyl-CoA hydratase A3N97_16170 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase A3N97_16180 ENOG4105C7N Xanthine uracil vitamin C permease A3N97_16195 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) A3N97_16220 ENOG4105WH1 Two component transcriptional regulator luxr family A3N97_16225 ENOG4105C10 Electron transfer flavoprotein A3N97_16235 ENOG4108KQJ Type 11 methyltransferase A3N97_16255 ENOG4105EW9 transcriptional regulator AsnC family A3N97_16260 ENOG4108UMN azlc family A3N97_16275 ENOG4108JGH Tetr family transcriptional regulator A3N97_16300 ENOG4105EVB acetyltransferase A3N97_16305 ENOG4108V0V Pyrrolo-quinoline quinone A3N97_16330 ENOG4105DKW ABC transporter A3N97_16340 ENOG4108VW9 Membrane A3N97_16345 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A3N97_16410 ENOG4105DQ4 alcohol dehydrogenase A3N97_16430 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A3N97_16435 ENOG4105CHR reductase A3N97_16455 ENOG4105C5Q Transcriptional regulator A3N97_16500 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) A3N97_16510 ENOG4105CSH Transporter A3N97_16525 ENOG4107RA1 nh(3)-dependent nad( ) synthetase A3N97_16530 ENOG4105CHR reductase A3N97_16560 ENOG4105CYX Short-chain dehydrogenase reductase Sdr A3N97_16585 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) A3N97_16595 ENOG4107ZR7 Membrane A3N97_16605 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_16620 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr A3N97_16625 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) A3N97_16675 ENOG41082VC UPF0145 protein A3N97_16680 ENOG4105EBR Carboxylesterase A3N97_16685 ENOG4105EBR Carboxylesterase A3N97_16695 ENOG4105CHU acetyl-coa acetyltransferase A3N97_16700 ENOG4107YPT transcriptional regulator A3N97_16730 ENOG4108JGH Tetr family transcriptional regulator A3N97_16760 ENOG4105KNI merR family transcriptional Regulator A3N97_16790 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) A3N97_16795 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) A3N97_16800 ENOG4105CAK Cell division ATP-binding protein ftsE A3N97_16810 ENOG4105D8X mechanosensitive ion channel A3N97_16815 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) A3N97_16850 ENOG4107TK4 histidinol-phosphate phosphatase A3N97_16855 ENOG4105C1G acyl-Coa dehydrogenase A3N97_16860 ENOG4105C1G acyl-Coa dehydrogenase A3N97_16875 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_16885 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit A3N97_16925 ENOG4105DJZ UPF0182 protein A3N97_16930 ENOG41063PX domain protein A3N97_16935 ENOG4105KIR Thiol-disulfide oxidoreductase dcc A3N97_16950 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) A3N97_16955 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) A3N97_16965 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) A3N97_16995 ENOG4105CKD glutathione-regulated potassium-efflux system protein A3N97_17010 ENOG4108YIQ Alpha beta hydrolase A3N97_17025 ENOG4108KXV response regulator A3N97_17035 ENOG4107QZF nitrite reductase NADPH large subunit A3N97_17040 ENOG4105DQQ Major facilitator superfamily MFS_1 A3N97_17080 ENOG4105C1J atp-dependent rna helicase A3N97_17095 ENOG4108ZM9 phosphoglycerate mutase A3N97_17115 ENOG4107TE5 Lipid kinase A3N97_17130 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit A3N97_17140 ENOG4105EMN RNA polymerase sigma factor A3N97_17145 ENOG4108Z66 YbaK ebsC protein A3N97_17150 ENOG4108RAV Conserved protein A3N97_17155 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase A3N97_17160 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) A3N97_17195 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) A3N97_17200 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving A3N97_17215 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea A3N97_17225 ENOG4108RZE Tetr family transcriptional regulator A3N97_17240 ENOG4108T3R lipoprotein lpqB A3N97_17245 ENOG4105BZU Histidine kinase A3N97_17255 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_17280 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) A3N97_17290 ENOG4105VCQ rubredoxin A3N97_17295 ENOG41084UD rubredoxin A3N97_17300 ENOG4105EEF Alkane 1-monooxygenase A3N97_17305 ENOG4105CUB amino acid A3N97_17315 ENOG4105EIP mannose-6-phosphate isomerase A3N97_17340 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) A3N97_17345 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase A3N97_17350 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) A3N97_17380 ENOG4107TB5 TRANSCRIPTIONal A3N97_17400 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) A3N97_17410 ENOG4105E2B Taurine dioxygenase A3N97_17415 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein A3N97_17435 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase A3N97_17445 ENOG4105J5T Amp-dependent synthetase and ligase A3N97_17460 ENOG4105D8K carboxyl transferase A3N97_17470 ENOG4107WR6 Maf-like protein A3N97_17485 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A3N97_17490 ENOG4105C6Z Gluconate A3N97_17495 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family A3N97_17515 ENOG4105DEN Luciferase family A3N97_17535 ENOG4108JIK carboxylase A3N97_17570 ENOG4105C26 Dehydrogenase A3N97_17580 ENOG4107QRT dEAD DEAH box helicase A3N97_17595 ENOG4105D3G Pseudouridine synthase A3N97_17615 ENOG4107RM1 amidohydrolase A3N97_17630 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain A3N97_17635 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) A3N97_17645 ENOG4105ZXU NLP P60 protein A3N97_17675 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) A3N97_17705 ENOG4105E33 succinate dehydrogenase A3N97_17710 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) A3N97_17715 ENOG4108KPJ rna polymerase sigma factor A3N97_17725 ENOG4105DZ1 carboxypeptidase A3N97_17740 ENOG4105CGK Exodeoxyribonuclease III A3N97_17750 ENOG4105E9K Isocitrate dehydrogenase A3N97_17780 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) A3N97_17800 ENOG4105KVH Transcriptional regulator A3N97_17805 ENOG4108RYK Nad-dependent epimerase dehydratase A3N97_17810 ENOG4105IDI abc transporter atp-binding protein A3N97_17815 ENOG4107Z6C Pentapeptide repeat-containing protein A3N97_17820 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) A3N97_17825 ENOG4105C0B DNA polymerase III (alpha subunit) A3N97_17830 ENOG4105ENX hydrolase A3N97_17900 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) A3N97_17910 ENOG4107QVP Dehydrogenase A3N97_17920 ENOG4108VT4 A3N97_17940 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) A3N97_17965 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) A3N97_17970 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) A3N97_17980 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A3N97_17985 ENOG41080E2 ribosomal-protein-alanine acetyltransferase A3N97_18010 ENOG4105CVK Glutamate decarboxylase A3N97_18020 ENOG4108JNI Alpha beta hydrolase A3N97_18025 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) A3N97_18050 ENOG4105DYW oxidoreductase A3N97_18060 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) A3N97_18065 ENOG4108UJD 30S ribosomal protein S9 A3N97_18070 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) A3N97_18100 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin A3N97_18130 ENOG4105D74 hydrolase A3N97_18155 ENOG4108ZT0 50S ribosomal protein l17 A3N97_18160 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A3N97_18165 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) A3N97_18170 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) A3N97_18175 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits A3N97_18180 ENOG41067V7 50S ribosomal protein L36 A3N97_18200 ENOG4105DZ6 Band 7 protein A3N97_18210 ENOG4105C1B dTDP-glucose 4-6-dehydratase A3N97_18215 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase A3N97_18230 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) A3N97_18250 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) A3N97_18275 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) A3N97_18280 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) A3N97_18285 ENOG410849U 50S ribosomal protein L30 A3N97_18290 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) A3N97_18295 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) A3N97_18300 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) A3N97_18305 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) A3N97_18315 ENOG4105D82 Glutamate dehydrogenase A3N97_18325 ENOG4105EBR Carboxylesterase A3N97_18330 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) A3N97_18335 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits A3N97_18340 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) A3N97_18345 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) A3N97_18350 ENOG4105CSH Transporter A3N97_18365 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal A3N97_18370 ENOG41082SA 50s ribosomal protein l29 A3N97_18375 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) A3N97_18380 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) A3N97_18385 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) A3N97_18390 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) A3N97_18395 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity A3N97_18400 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) A3N97_18405 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) A3N97_18410 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) A3N97_18420 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) A3N97_18440 ENOG4107FQ9 ethanolamine ammonia-lyase A3N97_18445 ENOG4105CPD ethanolamine ammonia-lyase A3N97_18450 ENOG4105CUB amino acid A3N97_18455 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) A3N97_18480 ENOG4105XDV A3N97_18505 ENOG4105CIK Amidinotransferase A3N97_18510 ENOG4105C8Y Acetylornithine aminotransferase A3N97_18515 ENOG4105CUB amino acid A3N97_18545 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) A3N97_18550 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) A3N97_18555 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) A3N97_18590 ENOG4105E39 Enoyl-CoA hydratase A3N97_18605 ENOG4105CSU acyl-Coa dehydrogenase A3N97_18635 ENOG4105C85 amino acid A3N97_18645 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A3N97_18650 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A3N97_18655 ENOG4107QY8 reductase A3N97_18685 ENOG41082SK Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) A3N97_18690 ENOG4108VZM 50s ribosomal protein L10 A3N97_18695 ENOG4107UB2 Alpha beta hydrolase fold A3N97_18745 ENOG4105CHP RNA polymerase A3N97_18760 ENOG4107EFQ arachidonate 15-lipoxygenase A3N97_18765 ENOG4105BZU Histidine kinase A3N97_18770 ENOG4105EGI Transcriptional regulator A3N97_18830 ENOG4106TD9 Diguanylate cyclase A3N97_18860 ENOG4105CBN LysR family transcriptional regulator A3N97_18895 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) A3N97_18900 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) A3N97_18935 ENOG4105WDJ 50S ribosomal protein L33 A3N97_18955 ENOG4108Z0Z intracellular protease Pfpi family A3N97_18995 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin A3N97_19010 ENOG4108VPT UPF0234 protein A3N97_19015 ENOG410829K Lysine exporter protein (Lyse ygga) A3N97_19050 ENOG4107RN6 Monooxygenase A3N97_19085 ENOG4105D0M Protease HtpX homolog A3N97_19095 ENOG4105P52 geranylgeranyl reductase A3N97_19100 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A3N97_19115 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) A3N97_19125 ENOG4107TCW O-succinylbenzoate synthase A3N97_19145 ENOG4105BZU Histidine kinase A3N97_19150 ENOG4105EUB pirin domain protein A3N97_19160 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) A3N97_19170 ENOG4107SIQ Naphthoate synthase A3N97_19175 ENOG4108BAS reductase A3N97_19180 ENOG4105PDP Short chain dehydrogenase A3N97_19225 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) A3N97_19310 ENOG4105CRE cytochrome C A3N97_19315 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) A3N97_19320 ENOG4107QIV Cytochrome c biogenesis protein A3N97_19330 ENOG4108RH7 phosphoglycerate mutase A3N97_19335 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase A3N97_19345 ENOG4105C9K Endothelin-converting enzyme 1 A3N97_19395 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A3N97_19400 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) A3N97_19405 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) A3N97_19415 ENOG4108RXW HAD-superfamily subfamily IB hydrolase A3N97_19420 ENOG410900P UPF0336 protein A3N97_19445 ENOG4105EA8 2-Nitropropane dioxygenase A3N97_19465 ENOG4105II7 pyrroline-5-carboxylate reductase A3N97_19475 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta A3N97_19500 ENOG41063NU Membrane A3N97_19500 ENOG41063NU Membrane A3N97_19525 ENOG4107RN6 Monooxygenase A3N97_19560 ENOG4105F95 Monooxygenase A3N97_19635 ENOG4105F95 Monooxygenase A3N97_19650 ENOG4105F95 Monooxygenase A3N97_19675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3N97_19680 ENOG4105BZU Histidine kinase A3N97_19690 ENOG4105F95 Monooxygenase A3N97_19705 ENOG4105E0T Short-chain dehydrogenase reductase Sdr A3N97_19715 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_19720 ENOG4108YZJ Pfam:DUF2596 A3N97_19725 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) A3N97_19840 ENOG4105TT9 Protein of unknown function (DUF2516) A3N97_19845 ENOG4105V9F hemagglutinin A3N97_19855 ENOG4106BRA Membrane A3N97_19865 ENOG4105CSR polyphosphate kinase 2 A3N97_19870 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase A3N97_19905 ENOG4107RPH Isocitrate lyase A3N97_19945 ENOG4108YRB methyltransferase A3N97_19995 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) A3N97_20030 ENOG4105CPC Aldo Keto reductase A3N97_20055 ENOG4105CPU Monooxygenase A3N97_20100 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 A3N97_20105 ENOG4105CSR polyphosphate kinase 2 A3N97_20120 ENOG4106UW1 Major Facilitator superfamily A3N97_20125 ENOG41082BM Transcriptional regulator, arsr family A3N97_20155 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase A3N97_20210 ENOG4105CHR reductase A3N97_20220 ENOG4105X7H acyl-CoA dehydrogenase A3N97_20225 ENOG4108KC2 acyl-Coa dehydrogenase A3N97_20250 ENOG4105E39 Enoyl-CoA hydratase A3N97_20255 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) A3N97_20260 ENOG4105DYW oxidoreductase A3N97_20290 ENOG4108Z0R Transferase A3N97_20295 ENOG4105CIJ rieske 2fe-2S domain-containing protein A3N97_20305 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) A3N97_20335 ENOG4105C11 sulfate adenylyltransferase), subunit 2 A3N97_20345 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) A3N97_20365 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A3N97_20370 ENOG4105KEG ribosomal-protein-alanine acetyltransferase A3N97_20405 ENOG4105C0R drug resistance transporter emrb qaca subfamily A3N97_20410 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) A3N97_20415 ENOG4105DWF phosphomethylpyrimidine kinase A3N97_20435 ENOG4108SGK Tetr family transcriptional regulator A3N97_20445 ENOG4105C26 Dehydrogenase A3N97_20460 ENOG4105D5Q Arginine ornithine antiporter A3N97_20490 ENOG4105IIU Aminopeptidase A3N97_20495 ENOG4105IIU Aminopeptidase A3N97_20505 ENOG4105CJ1 ABC, transporter A3N97_20510 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) A3N97_20545 ENOG4105CT1 (ABC) transporter A3N97_20550 ENOG4107Q25 Serine Threonine protein kinase A3N97_20555 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) A3N97_20580 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone A3N97_20590 ENOG4105CPU Monooxygenase A3N97_20595 ENOG4105DEN Luciferase family A3N97_20600 ENOG4105CPU Monooxygenase A3N97_20610 ENOG4105EAB amino acid AbC transporter A3N97_20615 ENOG4105CDA abc transporter atp-binding protein A3N97_20620 ENOG4105E5Q amino acid AbC transporter A3N97_20655 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR A3N97_20675 ENOG4105CVP deoxyribo-dipyrimidine photolyase A3N97_20680 ENOG4105ECP epimerase A3N97_20705 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase A3N97_20715 ENOG4105K6V RNA polymerase A3N97_20720 ENOG4105RSG Anti-sigma-K factor RskA A3N97_20730 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis A3N97_20740 ENOG4107XZ0 Peptidase M50 A3N97_20760 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN A3N97_20790 ENOG4105EMU Dehydrogenase A3N97_20810 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit A3N97_20835 ENOG4105KNI merR family transcriptional Regulator A3N97_20845 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ A3N97_20850 ENOG4105CFG Acts as a chaperone (By similarity) A3N97_20915 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) A3N97_20935 ENOG4105NQG DoxX A3N97_20955 ENOG4105DF6 Fe-S oxidoreductase A3N97_20965 ENOG4105C6Y Udp-glucose 6-dehydrogenase A3N97_20975 ENOG4105DHP deoxycytidine triphosphate deaminase A3N97_21005 ENOG4105EX0 alpha-galactosidase A3N97_21010 ENOG4105E6M Sulphatase-modifying factor protein A3N97_21020 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) A3N97_21030 ENOG4105C0H protease A3N97_21095 ENOG4105C26 Dehydrogenase A3N97_21100 ENOG4105D5Q Arginine ornithine antiporter A3N97_21125 ENOG4105IIV Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) A3N97_21140 ENOG4107XDR Lactoylglutathione lyase A3N97_21160 ENOG4105CHR reductase A3N97_21165 ENOG4105D2B acyl-CoA dehydrogenase A3N97_21180 ENOG4105EG6 Saccharopine dehydrogenase A3N97_21185 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_21190 ENOG4105DQE DNA ligase A3N97_21200 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A3N97_21205 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_21250 ENOG4108HUF Transporter A3N97_21265 ENOG4105P4J Allophanate hydrolase, subunit 1 A3N97_21270 ENOG4107R7A Allophanate hydrolase subunit 2 A3N97_21320 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) A3N97_21330 ENOG4105C5Q Transcriptional regulator A3N97_21335 ENOG4105CR4 methylisocitrate lyase A3N97_21340 ENOG4105G3Z GntR family transcriptional regulator A3N97_21360 ENOG4105DV0 amidase (EC 3.5.1.4 A3N97_21370 ENOG4108JPW Aminotransferase A3N97_21380 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A3N97_21395 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) A3N97_21415 ENOG4105MHT Transcriptional regulator, ARSR family A3N97_21425 ENOG4105CHR reductase A3N97_21470 ENOG4105CSU acyl-Coa dehydrogenase A3N97_21485 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) A3N97_21495 ENOG4105CHU acetyl-coa acetyltransferase A3N97_21500 ENOG4105CHR reductase A3N97_21515 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein A3N97_21520 ENOG4105CHH sulfate transporter A3N97_21525 ENOG4107Z3H Transcriptional regulator, TetR family A3N97_21530 ENOG4105EE5 Membrane protein terC A3N97_21570 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) A3N97_21575 ENOG4105CHP RNA polymerase A3N97_21610 ENOG4105CBG Sulfatase A3N97_21625 ENOG41073B4 coagulation factor 5 8 type domain-containing protein A3N97_21640 ENOG4107RN6 Monooxygenase A3N97_21660 ENOG4108I69 Glycosyl transferases group 1 A3N97_21665 ENOG4108M6P methyltransferase A3N97_21715 ENOG4105WH1 Two component transcriptional regulator luxr family A3N97_21720 ENOG4105BZU Histidine kinase A3N97_21725 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) A3N97_21740 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) A3N97_21770 ENOG4107R13 MMPL domain protein A3N97_21815 ENOG4105CY3 ABC transporter, permease A3N97_21825 ENOG4105WH1 Two component transcriptional regulator luxr family A3N97_21855 ENOG4108YYC ycei family A3N97_21875 ENOG4107WA4 MmpL domain-containing protein A3N97_21895 ENOG4105K4P CoA-binding domain protein A3N97_21910 ENOG4105C9K Endothelin-converting enzyme 1 A3N97_21915 ENOG4105S7A ErfK ybiS ycfS ynhG family protein A3N97_21920 ENOG4105C1G acyl-Coa dehydrogenase A3N97_21930 ENOG4107QX3 carboxylase A3N97_21940 ENOG4105VPX protein, conserved in bacteria A3N97_21955 ENOG4105C01 Dihydroxy-acid dehydratase A3N97_21965 ENOG4105C26 Dehydrogenase A3N97_21985 ENOG4105E5G Alpha beta hydrolase fold A3N97_22000 ENOG4105CD8 aminopeptidase N A3N97_22015 ENOG4108V0P LemA family A3N97_22025 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_22080 ENOG4105CGU Enoyl-CoA hydratase A3N97_22085 ENOG4108WYP Transcriptional regulator A3N97_22095 ENOG4105D74 hydrolase A3N97_22100 ENOG4108R86 Transcriptional regulator A3N97_22115 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) A3N97_22120 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) A3N97_22125 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) A3N97_22130 ENOG4105CHF Glutathione S-transferase A3N97_22150 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) A3N97_22155 ENOG4108XZR Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) A3N97_22170 ENOG4106YT9 Enoyl-CoA hydratase A3N97_22180 ENOG4105EAA nucleoside A3N97_22250 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr A3N97_22255 ENOG4105C26 Dehydrogenase A3N97_22260 ENOG4108UGJ Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) A3N97_22265 ENOG4108XB2 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) A3N97_22270 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) A3N97_22275 ENOG4105C1G acyl-Coa dehydrogenase A3N97_22310 ENOG4105CFF transcriptional regulator A3N97_22320 ENOG4105CR4 methylisocitrate lyase A3N97_22325 ENOG4105BZN citrate synthase A3N97_22360 ENOG4105CEY Amp-dependent synthetase and ligase A3N97_22420 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) A3N97_22430 ENOG4105C01 Dihydroxy-acid dehydratase A3N97_22450 ENOG4105DV0 amidase (EC 3.5.1.4 A3N97_22455 ENOG4105JXH GntR family transcriptional regulator A3N97_22485 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase A3N97_22490 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F A3N97_22520 ENOG4105CHR reductase A3N97_22560 ENOG4105EWI Short-chain dehydrogenase reductase Sdr A3N97_22580 ENOG4107RCI amp-dependent synthetase and ligase A3N97_22585 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) A3N97_22590 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) A3N97_22600 ENOG4107QI6 Cysteine desulfurase A3N97_22615 ENOG4107QX3 carboxylase A3N97_22660 ENOG4107Z3H Transcriptional regulator, TetR family A3N97_22710 ENOG4107EMZ glycosyl transferase family A3N97_22810 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) A3N97_22870 ENOG4105DHU Bile acid A3N97_22890 ENOG4108KPJ rna polymerase sigma factor A3N97_22900 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction A3N97_22915 ENOG4105CH2 amidohydrolase A3N97_22940 ENOG4105CEP NADH dehydrogenase A3N97_22960 ENOG4105VPX protein, conserved in bacteria A3N97_23055 ENOG4105F0F Oxalate decarboxylase A3N97_23080 ENOG4108QER Adenylate cyclase A3N97_23100 ENOG41069FZ L,D-transpeptidase catalytic domain A3N97_23110 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) A3N97_23120 ENOG410900P UPF0336 protein A3N97_23125 ENOG4105C5H ABC transporter A3N97_23130 ENOG4108WKN secreted protein A3N97_23190 ENOG4105DND Transcriptional regulator A3N97_23215 ENOG4107QK9 Beta-lactamase A3N97_23220 ENOG4108WKN secreted protein A3N97_23245 ENOG4106F60 Histidine kinase A3N97_23250 ENOG4105ETX regulatoR A3N97_23270 ENOG4105CHC glucokinase (EC 2.7.1.2) A3N97_23315 ENOG4105CPC Aldo Keto reductase A3N97_23395 ENOG4108V0P LemA family A3N97_23445 ENOG4105K9Q Binds to the 23S rRNA (By similarity) A3N97_23450 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) A3N97_23455 ENOG4107YH6 single-stranded DNA-binding protein A3N97_23460 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) A3N97_23470 ENOG4105BZ4 penicillin-binding protein A3N97_23500 ENOG4105CZA synthase A3N97_23510 ENOG4105C85 amino acid A3N97_23525 ENOG4108RZE Tetr family transcriptional regulator A3N97_23530 ENOG4105CHR reductase A3N97_23545 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 A3N97_23550 ENOG4105CPP Dehydrogenase, E1 component A3N97_23570 ENOG4105DHF Membrane A3N97_23580 ENOG4105C8T Leucyl-tRNA synthetase A3N97_23585 ENOG41064CH Probable lipoprotein LpqN A3N97_23605 ENOG41081DT UPF0301 protein A3N97_23610 ENOG4108M0D major facilitator superfamily A3N97_23635 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate A3N97_23665 ENOG4105C3M thioredoxin reductase A3N97_23675 ENOG4108E1C hydrolase A3N97_23715 ENOG4107QJE Chromosome Partitioning Protein A3N97_23720 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) A3N97_23730 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins A3N97_23745 ENOG41084CH 50S ribosomal protein l34