locus-tag class description BAB76_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BAB76_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BAB76_00015 ENOG4108J5G 6-phosphogluconate dehydrogenase BAB76_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BAB76_00025 ENOG4105K7N UPF0232 protein BAB76_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BAB76_00120 ENOG4106NZI LysR family Transcriptional regulator BAB76_00135 ENOG4107ZXI Rhomboid family BAB76_00140 ENOG4106N8J Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) BAB76_00155 ENOG4105XBB septation inhibitor protein BAB76_00170 ENOG4105D9P serine threonine protein kinase BAB76_00175 ENOG4107TPY serine threonine protein kinase BAB76_00180 ENOG4105CJN penicillin-binding protein BAB76_00195 ENOG4105HZM Fha domain containing protein BAB76_00200 ENOG4105TV9 FHA Domain-Containing protein BAB76_00215 ENOG4106032 Glutathionylspermidine synthase BAB76_00225 ENOG4107MVR Transcriptional regulator BAB76_00245 ENOG4106V5Y EsaT-6 like protein BAB76_00265 ENOG4107Y2X deaminase BAB76_00270 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) BAB76_00275 ENOG4105DND Transcriptional regulator BAB76_00280 ENOG4105CQ7 ATP-dependent helicase BAB76_00285 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BAB76_00325 ENOG4105C1G acyl-Coa dehydrogenase BAB76_00370 ENOG4107S2E monooxygenase BAB76_00380 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase BAB76_00385 ENOG4107258 Transcriptional regulator BAB76_00405 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein BAB76_00435 ENOG4105G6Z alkaline phosphatase BAB76_00455 ENOG4105CBC glutamate synthase BAB76_00485 ENOG4105DCG PHP domain protein BAB76_00495 ENOG4105F95 Monooxygenase BAB76_00505 ENOG4106A3M Cytochrome p-450 BAB76_00520 ENOG4105E39 Enoyl-CoA hydratase BAB76_00535 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BAB76_00540 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) BAB76_00550 ENOG4105FXM Copper resistance protein BAB76_00600 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BAB76_00605 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BAB76_00620 ENOG4105BZU Histidine kinase BAB76_00625 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) BAB76_00630 ENOG4107YEV ferritin BAB76_00635 ENOG4107YEV ferritin BAB76_00640 ENOG4108KGH TRANSCRIPTIONal BAB76_00665 ENOG4105CQC Prephenate dehydratase BAB76_00670 ENOG4105GCF PGAM BAB76_00680 ENOG4105C7K acetolactate synthase BAB76_00710 ENOG4105F95 Monooxygenase BAB76_00720 ENOG4105F95 Monooxygenase BAB76_00740 ENOG4105KT7 mgtC SapB transporter BAB76_00775 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BAB76_00790 ENOG4107B57 rieske 2fe-2S domain-containing protein BAB76_00800 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) BAB76_00805 ENOG4105EA8 2-Nitropropane dioxygenase BAB76_00810 ENOG41090U3 tautomerase BAB76_00830 ENOG4105CHR reductase BAB76_00865 ENOG410602S Transferase BAB76_00875 ENOG4106YN8 Prenyltransferase BAB76_00880 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids BAB76_00905 ENOG4107RCI amp-dependent synthetase and ligase BAB76_00915 ENOG4105D8K carboxyl transferase BAB76_00925 ENOG4105PGM cation diffusion facilitator family transporter BAB76_00935 ENOG4105J1Z Arabinosyltransferase BAB76_00955 ENOG4105J1Z Arabinosyltransferase BAB76_00965 ENOG4108RG3 short-chain dehydrogenase reductase BAB76_00970 ENOG4105IQ5 FAD linked oxidase domain protein BAB76_00985 ENOG4105CMT Dihydroxyacetone kinase BAB76_00995 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BAB76_01000 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BAB76_01015 ENOG4105YVM Phosphoesterase, PA-phosphatase related BAB76_01025 ENOG4108MKI Glycosyl transferase, family 2 BAB76_01035 ENOG4108VC7 Protein of unknown function (DUF2587) BAB76_01100 ENOG4105C9B Cysteine desulfurase BAB76_01115 ENOG4105CIH Imidazole acetol-phosphate transaminase BAB76_01175 ENOG4105C1G acyl-Coa dehydrogenase BAB76_01195 ENOG4105CHR reductase BAB76_01215 ENOG4105E90 ABC transporter BAB76_01220 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component BAB76_01230 ENOG4105EVN Prephenate dehydrogenase BAB76_01240 ENOG4108Z6B deaminase BAB76_01280 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BAB76_01290 ENOG4105DRP amino acid AbC transporter BAB76_01295 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) BAB76_01305 ENOG4105DQE DNA ligase BAB76_01335 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BAB76_01360 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase BAB76_01375 ENOG4105EBR Carboxylesterase BAB76_01385 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BAB76_01405 ENOG4108JGH Tetr family transcriptional regulator BAB76_01410 ENOG4105EBR Carboxylesterase BAB76_01415 ENOG41061H0 Monooxygenase BAB76_01430 ENOG4105XT2 Transcriptional regulator BAB76_01455 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BAB76_01465 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BAB76_01495 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase BAB76_01505 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BAB76_01520 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BAB76_01525 ENOG4105DFU Cell wall formation (By similarity) BAB76_01545 ENOG4105C1G acyl-Coa dehydrogenase BAB76_01560 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BAB76_01565 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BAB76_01570 ENOG4105W0E 50S ribosomal protein L33 BAB76_01585 ENOG4105NRA 50s ribosomal protein l31 type b BAB76_01590 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BAB76_01615 ENOG4105CFH Aspartokinase BAB76_01620 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BAB76_01630 ENOG4108NJC BAB76_01635 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BAB76_01645 ENOG4105F2Z 3-oxoadipate enol-lactonase BAB76_01655 ENOG4105CH6 catalase BAB76_01715 ENOG4105CE4 GlcNAc 6-P deacetylase BAB76_01720 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BAB76_01725 ENOG4105RD7 BadF BadG BcrA BcrD BAB76_01730 ENOG4107QNK )-transporter BAB76_01750 ENOG4105D1K glutamate--cysteine ligase BAB76_01755 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process BAB76_01760 ENOG4108V75 Glutamine amidotransferase BAB76_01765 ENOG41067HS methyltransferase BAB76_01800 ENOG410900P UPF0336 protein BAB76_01805 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr BAB76_01810 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BAB76_01820 ENOG4105NTW Transcriptional regulator BAB76_01850 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BAB76_01855 ENOG4108WQ6 secreted protein BAB76_01895 ENOG4105C7H Helicase, RecD TraA family BAB76_01900 ENOG4107QKA exodeoxyribonuclease V beta BAB76_01905 ENOG4105DSY exodeoxyribonuclease V, gamma BAB76_01950 ENOG4105DIN metallophosphoesterase BAB76_01955 ENOG4108JQC penicillin-binding protein 1A BAB76_01960 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BAB76_01985 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BAB76_02025 ENOG4108XEP Alpha Beta Hydrolase Fold protein BAB76_02040 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BAB76_02045 ENOG4105DEF Extracellular solute-binding protein, family 5 BAB76_02055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BAB76_02125 ENOG41089PS Recombinase BAB76_02130 ENOG4108KU9 integrase family BAB76_02180 ENOG410880H cysteine synthase BAB76_02220 ENOG4107T94 Endo-14-beta-xylanase BAB76_02240 ENOG4107R16 Multicopper oxidase BAB76_02265 ENOG4107B2H carbonic anhydrase BAB76_02275 ENOG4108YIQ Alpha beta hydrolase BAB76_02410 ENOG4105ES4 Nitrilase BAB76_02415 ENOG4108Q5F Tetr family transcriptional regulator BAB76_02425 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BAB76_02430 ENOG4108I5C dEAD DEAH box helicase BAB76_02435 ENOG4105VEQ Cold shock protein BAB76_02445 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BAB76_02455 ENOG4105C6E dna polymerase iii BAB76_02565 ENOG4105C9B Cysteine desulfurase BAB76_02570 ENOG4107RN6 Monooxygenase BAB76_02600 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BAB76_02620 ENOG4108UGV hypoxanthine phosphoribosyltransferase BAB76_02635 ENOG4105CPQ Dehydrogenase BAB76_02645 ENOG4105D74 hydrolase BAB76_02655 ENOG4105MKU Transcriptional regulator BAB76_02675 ENOG4105EUJ GTP cyclohydrolase i BAB76_02710 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BAB76_02715 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BAB76_02720 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BAB76_02725 ENOG4105CRK lysyL-tRNA synthetase BAB76_02735 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BAB76_02745 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BAB76_02750 ENOG4105EHG Permease protein BAB76_02775 ENOG41082A2 Alpha beta hydrolase BAB76_02780 ENOG4105HSS phospholipase C BAB76_02795 ENOG4105CEN a g-specific adenine glycosylase BAB76_02805 ENOG4107TB5 TRANSCRIPTIONal BAB76_02815 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BAB76_02825 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BAB76_02845 ENOG4108VJ1 Transcriptional regulator (CarD family BAB76_02850 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BAB76_02855 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BAB76_02860 ENOG4105C8N cysteinyl-tRNA synthetase BAB76_02865 ENOG4105C2N RNA methyltransferase TrmH family group 3 BAB76_02870 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BAB76_02880 ENOG4105CC5 ABC transporter BAB76_02885 ENOG4105E0A ABC, transporter BAB76_02890 ENOG4107XSR periplasmic solute binding protein BAB76_02900 ENOG4108SGK Tetr family transcriptional regulator BAB76_02905 ENOG4105D2B acyl-CoA dehydrogenase BAB76_02920 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BAB76_02930 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase BAB76_02940 ENOG4107SCA Formamidase (EC 3.5.1.49) BAB76_02950 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BAB76_02970 ENOG4105D2B acyl-CoA dehydrogenase BAB76_02975 ENOG4105D2B acyl-CoA dehydrogenase BAB76_02980 ENOG4105CC9 acyl-Coa dehydrogenase BAB76_02985 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_02990 ENOG4105CC9 acyl-Coa dehydrogenase BAB76_03005 ENOG4105F2C Acetyl-CoA acetyltransferase BAB76_03020 ENOG4105EA8 2-Nitropropane dioxygenase BAB76_03035 ENOG4105E39 Enoyl-CoA hydratase BAB76_03040 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BAB76_03045 ENOG4105CHR reductase BAB76_03065 ENOG4105F2C Acetyl-CoA acetyltransferase BAB76_03075 ENOG4108RK3 acyl-Coa dehydrogenase BAB76_03080 ENOG4105X7H acyl-CoA dehydrogenase BAB76_03085 ENOG410900P UPF0336 protein BAB76_03115 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein BAB76_03130 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) BAB76_03135 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) BAB76_03170 ENOG4108JPZ Monovalent cation H antiporter subunit D BAB76_03180 ENOG4105D65 subunit l BAB76_03195 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme BAB76_03205 ENOG4105D4U had-superfamily hydrolase, subfamily iia BAB76_03230 ENOG4105PDP Short chain dehydrogenase BAB76_03265 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BAB76_03315 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_03330 ENOG4106V5Y EsaT-6 like protein BAB76_03370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAB76_03375 ENOG4105BZU Histidine kinase BAB76_03380 ENOG4107ZUX Histidine triad (HIT) protein BAB76_03385 ENOG4108594 Permease of the drug metabolite transporter BAB76_03395 ENOG4105D74 hydrolase BAB76_03425 ENOG4105CHM Aminotransferase BAB76_03435 ENOG4105C83 adenylosuccinate lyase BAB76_03445 ENOG4105C8V SAICAR synthetase BAB76_03455 ENOG4105CHR reductase BAB76_03475 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein BAB76_03485 ENOG410839H phosphoribosylformylglycinamidine synthase BAB76_03500 ENOG4105EZR dyp-type peroxidase family protein BAB76_03505 ENOG4105DFM M18 family aminopeptidase BAB76_03530 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BAB76_03555 ENOG4107P26 BAB76_03585 ENOG4105C1B dTDP-glucose 4-6-dehydratase BAB76_03595 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BAB76_03600 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BAB76_03605 ENOG4108JQ6 ABC transporter BAB76_03635 ENOG4105CXB phosphoribosylaminoimidazole synthetase BAB76_03645 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) BAB76_03655 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands BAB76_03690 ENOG4105PKJ carbohydrate binding BAB76_03695 ENOG4105KHC sulfurtransferase BAB76_03715 ENOG4107NHD transcriptional regulator BAB76_03720 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BAB76_03725 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) BAB76_03735 ENOG4105E2Z phosphate ABC transporter (Permease BAB76_03740 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BAB76_03745 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BAB76_03825 ENOG4108Q5Y Membrane BAB76_03845 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BAB76_03850 ENOG4105D2S major facilitator superfamily BAB76_03940 ENOG4105VTR Integrase BAB76_03995 ENOG4105CNU cell division protein FtsK BAB76_04195 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BAB76_04410 ENOG410839U amino acid BAB76_04415 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) BAB76_04420 ENOG4105C26 Dehydrogenase BAB76_04435 ENOG4105C7I Dehydrogenase BAB76_04440 ENOG4108JPW Aminotransferase BAB76_04445 ENOG4105C1G acyl-Coa dehydrogenase BAB76_04450 ENOG4105C26 Dehydrogenase BAB76_04455 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BAB76_04470 ENOG4105F6U Short-chain dehydrogenase reductase Sdr BAB76_04480 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BAB76_04510 ENOG4105E39 Enoyl-CoA hydratase BAB76_04555 ENOG410846T CoA-transferase family III BAB76_04580 ENOG4105CHU acetyl-coa acetyltransferase BAB76_04630 ENOG4105CFI type iii restriction protein res subunit BAB76_04670 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BAB76_04685 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BAB76_04690 ENOG4105VEQ Cold shock protein BAB76_04730 ENOG4107SFI Major Facilitator superfamily BAB76_04800 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BAB76_04810 ENOG4107QSN dihydrolipoamide acetyltransferase BAB76_04825 ENOG4105EW9 transcriptional regulator AsnC family BAB76_04835 ENOG4105DXM phenylacetic acid degradation protein BAB76_04840 ENOG4108IG5 Transcriptional regulator BAB76_04845 ENOG4105CHU acetyl-coa acetyltransferase BAB76_04850 ENOG4105E39 Enoyl-CoA hydratase BAB76_04855 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BAB76_04865 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit BAB76_04870 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit BAB76_04875 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit BAB76_04880 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit BAB76_04885 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BAB76_04910 ENOG4105ERH Fumarylacetoacetate hydrolase BAB76_04920 ENOG4106A3M Cytochrome p-450 BAB76_04950 ENOG4108ZHJ Organic hydroperoxide resistance protein BAB76_04955 ENOG4105K56 Transcriptional regulator BAB76_04960 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BAB76_04965 ENOG4105EDW glycosyl transferase, family 39 BAB76_04970 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BAB76_04975 ENOG4105URP P-aminobenzoate N-oxygenase AurF BAB76_04995 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) BAB76_05005 ENOG4107RCI amp-dependent synthetase and ligase BAB76_05030 ENOG4105E8G Major facilitator Superfamily BAB76_05065 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BAB76_05075 ENOG4108JPW Aminotransferase BAB76_05080 ENOG4108IQI permease BAB76_05090 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr BAB76_05095 ENOG4107YCY Transcriptional regulator BAB76_05100 ENOG41081K0 peptidylprolyl cis-trans isomerase BAB76_05120 ENOG4105H3G oxidoreductase BAB76_05140 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BAB76_05190 ENOG4105C26 Dehydrogenase BAB76_05205 ENOG4107XFJ UPF0246 protein BAB76_05215 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BAB76_05250 ENOG41060BG Tetr family transcriptional regulator BAB76_05285 ENOG4105K89 arsenate reductase BAB76_05290 ENOG4108W5M transcriptional regulator BAB76_05330 ENOG4105CHU acetyl-coa acetyltransferase BAB76_05390 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BAB76_05415 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BAB76_05465 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) BAB76_05475 ENOG4105K56 Transcriptional regulator BAB76_05530 ENOG4105CSR polyphosphate kinase 2 BAB76_05545 ENOG4106KE4 Dehydrogenase BAB76_05560 ENOG4105CKI cobalamin synthesis protein BAB76_05565 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BAB76_05570 ENOG4108S8N class II Aldolase BAB76_05580 ENOG4105E0X reductase BAB76_05585 ENOG4107QP8 phosphohexose isomerase BAB76_05610 ENOG4105CMV Succinyl-CoA synthetase subunit beta BAB76_05630 ENOG4105FBW Monooxygenase BAB76_05695 ENOG4107QX3 carboxylase BAB76_05715 ENOG4105ETX regulatoR BAB76_05725 ENOG4105C0H protease BAB76_05730 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BAB76_05760 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase BAB76_05765 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BAB76_05800 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BAB76_05805 ENOG4105C3J Cysteine desulfurase BAB76_05950 ENOG4105CEU Arginine dihydrolase BAB76_05965 ENOG4105CRQ synthase (Component I) BAB76_05990 ENOG4105F8V Hydrolase, tatD family BAB76_05995 ENOG4106839 domain protein BAB76_06000 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BAB76_06010 ENOG4105D9P serine threonine protein kinase BAB76_06050 ENOG410645S MarR family Transcriptional regulator BAB76_06055 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BAB76_06060 ENOG4107RCI amp-dependent synthetase and ligase BAB76_06065 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BAB76_06070 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BAB76_06075 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BAB76_06100 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BAB76_06110 ENOG4108RZE Tetr family transcriptional regulator BAB76_06155 ENOG4105DXN mazG family BAB76_06160 ENOG4105EKT )-iron permease BAB76_06170 ENOG4105DBE peroxidase BAB76_06175 ENOG410650H (LipO)protein BAB76_06190 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BAB76_06210 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BAB76_06245 ENOG4105CYC Transferase BAB76_06295 ENOG4108ZT1 Transcriptional regulator BAB76_06310 ENOG4105E39 Enoyl-CoA hydratase BAB76_06320 ENOG4105C26 Dehydrogenase BAB76_06330 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BAB76_06335 ENOG4105CHU acetyl-coa acetyltransferase BAB76_06355 ENOG4105W8D rdd domain containing protein BAB76_06370 ENOG4105C7B Threonine dehydratase BAB76_06380 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BAB76_06390 ENOG4105T1M mycothiol conjugate amidase mca BAB76_06400 ENOG4105C7Z Conserved Protein BAB76_06420 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BAB76_06425 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr BAB76_06430 ENOG4106A3M Cytochrome p-450 BAB76_06450 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BAB76_06490 ENOG4105EBR Carboxylesterase BAB76_06500 ENOG4105E90 ABC transporter BAB76_06505 ENOG4108IJ8 ABC transporter BAB76_06510 ENOG4105E90 ABC transporter BAB76_06515 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system BAB76_06545 ENOG4105CS9 pantothenic acid kinase BAB76_06555 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BAB76_06565 ENOG4108IAB Phoh family BAB76_06570 ENOG4107VMI polysaccharide deacetylase BAB76_06640 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BAB76_06650 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BAB76_06665 ENOG4105D22 carbon starvation protein BAB76_06690 ENOG4105K78 MarR family Transcriptional regulator BAB76_06695 ENOG4105C3G gtp-binding protein BAB76_06715 ENOG4107R16 Multicopper oxidase BAB76_06725 ENOG410880H cysteine synthase BAB76_06735 ENOG4105C5H ABC transporter BAB76_06795 ENOG4107R13 MMPL domain protein BAB76_06830 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BAB76_06880 ENOG4108U8T Mannosyltransferase BAB76_06895 ENOG410842T Pterin carbinolamine dehydratase BAB76_06915 ENOG4105EUZ Beta-lactamase domain protein BAB76_06920 ENOG4105T16 Transcriptional regulator (AraC family) BAB76_06935 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) BAB76_06980 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BAB76_06990 ENOG4108Z4U Ferredoxin BAB76_07000 ENOG4105EDW glycosyl transferase, family 39 BAB76_07005 ENOG4105C26 Dehydrogenase BAB76_07010 ENOG41062BK proline dehydrogenase BAB76_07015 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_07040 ENOG4105R1U AraC Family Transcriptional Regulator BAB76_07055 ENOG4108URH decarboxylase BAB76_07085 ENOG4105C3Q Glycosyl transferase, family 2 BAB76_07100 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BAB76_07110 ENOG4107QPH glycogen) synthase BAB76_07115 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BAB76_07145 ENOG4105DIM ABC transporter BAB76_07150 ENOG4105CIG ABC transporter BAB76_07155 ENOG4108X07 Tetr family transcriptional regulator BAB76_07160 ENOG4107ZBN O-methyltransferase BAB76_07165 ENOG4105DU6 RNA polymerase BAB76_07170 ENOG4106684 BAB76_07175 ENOG4105C0H protease BAB76_07245 ENOG4105D7N magnesium and cobalt transport protein CorA BAB76_07250 ENOG4107Z3H Transcriptional regulator, TetR family BAB76_07270 ENOG41076UM multiple antibiotic resistance (MarC)-related protein BAB76_07310 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BAB76_07315 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 BAB76_07320 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BAB76_07330 ENOG4105C2C drug resistance transporter, Bcr CflA BAB76_07390 ENOG4105CQB FAD linked oxidase domain protein BAB76_07395 ENOG41076PI Short-chain dehydrogenase reductase Sdr BAB76_07410 ENOG4105D8X mechanosensitive ion channel BAB76_07430 ENOG4105BZ1 (ABC) transporter BAB76_07465 ENOG4107T8P acyl-Coa dehydrogenase BAB76_07475 ENOG4105EJ2 Transcriptional regulator BAB76_07500 ENOG4105F27 Major Facilitator BAB76_07525 ENOG4105C75 arginyL-tRNA synthetase BAB76_07530 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BAB76_07535 ENOG4105D6E homoserine dehydrogenase BAB76_07540 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BAB76_07545 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BAB76_07570 ENOG4105VFB Binds the 23S rRNA (By similarity) BAB76_07575 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BAB76_07580 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BAB76_07590 ENOG4105ESV Glycosyl transferase, family 4 BAB76_07595 ENOG4105YV6 ATP synthase i BAB76_07600 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) BAB76_07605 ENOG410679R F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BAB76_07610 ENOG4105V1A F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BAB76_07615 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BAB76_07620 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BAB76_07625 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BAB76_07630 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BAB76_07650 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BAB76_07675 ENOG4105F8J Adenylate Guanylate cyclase BAB76_07680 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) BAB76_07695 ENOG4105CHU acetyl-coa acetyltransferase BAB76_07700 ENOG4105EYF MMPL domain protein BAB76_07715 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BAB76_07720 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) BAB76_07725 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BAB76_07740 ENOG4108RWI nicotinamidase BAB76_07750 ENOG4107RKP Nicotinate phosphoribosyltransferase BAB76_07765 ENOG4105KXX peptidase s58 dmpa BAB76_07800 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BAB76_07805 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BAB76_07810 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BAB76_07830 ENOG4107RCI amp-dependent synthetase and ligase BAB76_07845 ENOG4105EYH Exonuclease BAB76_07850 ENOG4106YT9 Enoyl-CoA hydratase BAB76_07860 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BAB76_07865 ENOG4107SCK Monooxygenase BAB76_07875 ENOG41080U6 GntR family transcriptional regulator BAB76_07890 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BAB76_07900 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BAB76_07940 ENOG4108YIQ Alpha beta hydrolase BAB76_07945 ENOG4108WKN secreted protein BAB76_07960 ENOG4108Z4K mutator MutT protein BAB76_07980 ENOG4108X07 Tetr family transcriptional regulator BAB76_07995 ENOG4105ENE Histidine kinase BAB76_08000 ENOG4105WH1 Two component transcriptional regulator luxr family BAB76_08010 ENOG4105CJW magnesium transporter BAB76_08020 ENOG4108IXY short-chain dehydrogenase reductase BAB76_08030 ENOG4105CV8 reductase BAB76_08065 ENOG4105D7A ATP-binding protein BAB76_08080 ENOG4105E1F short-chain dehydrogenase reductase BAB76_08095 ENOG4107QJT sodium dicarboxylate symporter BAB76_08105 ENOG4105C0X amino acid BAB76_08130 ENOG41061MV Arylsulfatase BAB76_08165 ENOG410870F Cyclic nucleotide-binding protein BAB76_08200 ENOG4105C7I Dehydrogenase BAB76_08220 ENOG4105CG3 alpha amylase, catalytic region BAB76_08255 ENOG4105MC2 DSBA oxidoreductase BAB76_08275 ENOG4105MKU Transcriptional regulator BAB76_08305 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BAB76_08310 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BAB76_08315 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BAB76_08320 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BAB76_08350 ENOG4105EJ2 Transcriptional regulator BAB76_08365 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BAB76_08375 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BAB76_08380 ENOG4105DQU oxidoreductase, subunit beta BAB76_08420 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BAB76_08425 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BAB76_08435 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BAB76_08440 ENOG4105C03 ribonuclease BAB76_08440 ENOG4105C03 ribonuclease BAB76_08455 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BAB76_08460 ENOG4105K46 50S ribosomal protein l27 BAB76_08465 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BAB76_08470 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BAB76_08490 ENOG4108RVA ribokinase BAB76_08495 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BAB76_08510 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BAB76_08520 ENOG4105CVJ phosphoglycerate mutase BAB76_08525 ENOG4108TZC BAB76_08575 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BAB76_08605 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BAB76_08620 ENOG4105BZP glycoside hydrolase 15-related BAB76_08635 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) BAB76_08665 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BAB76_08670 ENOG4107Z6A sulfate abc transporter permease BAB76_08730 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BAB76_08735 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BAB76_08750 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BAB76_08765 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BAB76_08780 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) BAB76_08785 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BAB76_08815 ENOG4105C1B dTDP-glucose 4-6-dehydratase BAB76_08830 ENOG4105DY8 decarboxylase BAB76_08865 ENOG4107RCI amp-dependent synthetase and ligase BAB76_08915 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BAB76_08920 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BAB76_08925 ENOG4105K6H D-cysteine desulfhydrase BAB76_08945 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BAB76_08995 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component BAB76_09010 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAB76_09015 ENOG4105BZU Histidine kinase BAB76_09030 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BAB76_09140 ENOG4105BZU Histidine kinase BAB76_09180 ENOG4105D4Y metalloprotease BAB76_09200 ENOG4105C1G acyl-Coa dehydrogenase BAB76_09205 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BAB76_09255 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BAB76_09260 ENOG4105C1G acyl-Coa dehydrogenase BAB76_09265 ENOG4105CHU acetyl-coa acetyltransferase BAB76_09280 ENOG4105KDM Diguanylate cyclase with gaf sensor BAB76_09285 ENOG4105CI2 imidazolone-5-propionate hydrolase BAB76_09335 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BAB76_09340 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BAB76_09365 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BAB76_09395 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F BAB76_09435 ENOG4105D9G High-affinity BAB76_09440 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) BAB76_09475 ENOG4105CVJ phosphoglycerate mutase BAB76_09500 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BAB76_09540 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BAB76_09560 ENOG4105C5F glutamine synthetase BAB76_09565 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BAB76_09595 ENOG4108TAG Histidine kinase BAB76_09625 ENOG4105C5F glutamine synthetase BAB76_09665 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BAB76_09670 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) BAB76_09685 ENOG41063C6 UPF0235 protein BAB76_09705 ENOG4105CM2 brancheD-chain amino acid aminotransferase BAB76_09715 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) BAB76_09720 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BAB76_09765 ENOG4108ZRS Part of cytochrome c oxidase, its function is BAB76_09800 ENOG4105CCU oxidase (Subunit III) BAB76_09805 ENOG4108I0Q anthranilate phosphoribosyltransferase BAB76_09840 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BAB76_09865 ENOG4105D0U Arsenite-activated ATPase (ArsA) BAB76_09875 ENOG4105PSQ Acyl-transferase BAB76_09880 ENOG4108VJY integral membrane protein BAB76_09890 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase BAB76_09905 ENOG4105KYH transcriptional regulatory protein BAB76_09910 ENOG41090CE integral membrane protein BAB76_09925 ENOG4105R14 (LipO)protein BAB76_09940 ENOG4108V6E Cell division protein mraZ BAB76_09945 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BAB76_09955 ENOG4105CJN penicillin-binding protein BAB76_09970 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BAB76_09975 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BAB76_09985 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BAB76_09990 ENOG4105DFU Cell wall formation (By similarity) BAB76_09995 ENOG4105ME9 cell division protein FtsQ BAB76_10015 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BAB76_10025 ENOG4105NPE arsR family transcriptional regulator BAB76_10080 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BAB76_10090 ENOG4105DWY Agmatine deiminase BAB76_10100 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BAB76_10110 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BAB76_10120 ENOG4105CHR reductase BAB76_10150 ENOG4105D94 Major Facilitator Superfamily BAB76_10250 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BAB76_10255 ENOG410900P UPF0336 protein BAB76_10275 ENOG4106YT9 Enoyl-CoA hydratase BAB76_10310 ENOG4107QX3 carboxylase BAB76_10340 ENOG4107RN6 Monooxygenase BAB76_10345 ENOG4107RN6 Monooxygenase BAB76_10355 ENOG4105F95 Monooxygenase BAB76_10370 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_10375 ENOG4105C1G acyl-Coa dehydrogenase BAB76_10395 ENOG4105C1G acyl-Coa dehydrogenase BAB76_10435 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BAB76_10445 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) BAB76_10495 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BAB76_10500 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo BAB76_10505 ENOG4105C8N cysteinyl-tRNA synthetase BAB76_10510 ENOG4108BAS reductase BAB76_10520 ENOG4107SQU synthase BAB76_10525 ENOG4107EEY synthase BAB76_10535 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_10545 ENOG4105C0W non-ribosomal peptide synthetase BAB76_10555 ENOG4105DMF Dehydrogenase BAB76_10560 ENOG4105EN6 Membrane BAB76_10575 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 BAB76_10580 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase BAB76_10585 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BAB76_10600 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BAB76_10605 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BAB76_10610 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BAB76_10620 ENOG4107QIZ NADH dehydrogenase BAB76_10625 ENOG4108IEH NADH dehydrogenase subunit g BAB76_10630 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) BAB76_10635 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BAB76_10640 ENOG4105DF2 NADH dehydrogenase subunit j BAB76_10645 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BAB76_10660 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BAB76_10715 ENOG4105C1J atp-dependent rna helicase BAB76_10740 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) BAB76_10755 ENOG4105C7K acetolactate synthase BAB76_10770 ENOG4105CIH Imidazole acetol-phosphate transaminase BAB76_10780 ENOG4105E5F proteasome BAB76_10785 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) BAB76_10790 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) BAB76_10795 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) BAB76_10810 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BAB76_10815 ENOG4106FTQ Taurine ABC transporter, periplasmic BAB76_10820 ENOG4108IY8 ABC, transporter BAB76_10825 ENOG4107S1E Beta-lactamase BAB76_10840 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) BAB76_10855 ENOG4107TMB Transcriptional regulator BAB76_10860 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BAB76_10895 ENOG4108RG3 short-chain dehydrogenase reductase BAB76_10930 ENOG4105CTK cobaltochelatase, cobn subunit BAB76_10950 ENOG4105EFZ amidohydrolase BAB76_10960 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BAB76_10965 ENOG4105CHR reductase BAB76_10970 ENOG4105Q70 BAB76_11010 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BAB76_11020 ENOG4105GVF (ABC) transporter BAB76_11025 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BAB76_11045 ENOG4105KAV tspo and mbr like protein BAB76_11050 ENOG4106VYT conserved transmembrane protein BAB76_11055 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin BAB76_11070 ENOG4106V5Y EsaT-6 like protein BAB76_11100 ENOG4106F1P AAA ATPase, central domain protein BAB76_11115 ENOG41061H0 Monooxygenase BAB76_11120 ENOG4105DND Transcriptional regulator BAB76_11150 ENOG4108IYU L-aspartate oxidase BAB76_11160 ENOG4108Z6Z Transcriptional regulator BAB76_11165 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BAB76_11195 ENOG4105JQZ Methyltransferase BAB76_11205 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_11220 ENOG4105C0W non-ribosomal peptide synthetase BAB76_11245 ENOG4105CSH Transporter BAB76_11250 ENOG4105EV8 ectoine hydroxylase BAB76_11255 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) BAB76_11260 ENOG4108JPW Aminotransferase BAB76_11265 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase BAB76_11285 ENOG4105DBE peroxidase BAB76_11295 ENOG4105JXH GntR family transcriptional regulator BAB76_11300 ENOG4105DJ2 Major Facilitator Superfamily BAB76_11310 ENOG4107R13 MMPL domain protein BAB76_11355 ENOG4107T3I fad-binding protein BAB76_11360 ENOG4107RWR Sodium hydrogen exchanger BAB76_11420 ENOG4108SM1 rRNA (Adenine-N(6)-)-methyltransferase BAB76_11425 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BAB76_11480 ENOG4108Z4X TRANSCRIPTIONal BAB76_11515 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_11530 ENOG4105CRK lysyL-tRNA synthetase BAB76_11545 ENOG41084BS 50S ribosomal protein L35 BAB76_11550 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BAB76_11610 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BAB76_11615 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BAB76_11620 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BAB76_11625 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BAB76_11630 ENOG4105CAS nag kinase BAB76_11635 ENOG4105C8Y Acetylornithine aminotransferase BAB76_11640 ENOG4105DBV ornithine carbamoyltransferase BAB76_11645 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BAB76_11650 ENOG4105CDH Citrulline--aspartate ligase BAB76_11655 ENOG4105CH7 arginosuccinase BAB76_11690 ENOG4105W49 UPF0434 protein BAB76_11700 ENOG4108VX5 3-methyladenine DNA glycosylase BAB76_11725 ENOG4105DSU hydrolase BAB76_11740 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BAB76_11760 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BAB76_11785 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BAB76_11800 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BAB76_11870 ENOG4108R0M Aminoglycoside BAB76_11890 ENOG4107EFR Flavocytochrome c BAB76_11920 ENOG4105C1G acyl-Coa dehydrogenase BAB76_11955 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BAB76_11980 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BAB76_11990 ENOG4107QP3 malate synthase g BAB76_11995 ENOG4107UAX integral membrane protein BAB76_12000 ENOG4105C37 (CBS) domain BAB76_12010 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BAB76_12060 ENOG4108YZ9 Urea amidohydrolase subunit gamma BAB76_12070 ENOG4105CQM Urea amidohydrolase subunit alpha BAB76_12075 ENOG4108ZJ1 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) BAB76_12080 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) BAB76_12090 ENOG4105CEP NADH dehydrogenase BAB76_12100 ENOG4105DYW oxidoreductase BAB76_12135 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BAB76_12145 ENOG41083TI Protein CrcB homolog BAB76_12160 ENOG4105CEV competence damage-inducible protein BAB76_12170 ENOG4105ECQ AraC Family Transcriptional Regulator BAB76_12175 ENOG4105EUB pirin domain protein BAB76_12195 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BAB76_12200 ENOG4108SEA Esterase BAB76_12225 ENOG4105DNP FAD linked oxidase domain protein BAB76_12235 ENOG4105J7D transcriptional regulator BAB76_12250 ENOG4108IJ6 ABC transporter BAB76_12255 ENOG4105I5W Transporter BAB76_12260 ENOG4105DG7 nitrate ABC transporter BAB76_12295 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) BAB76_12315 ENOG4105ZXU NLP P60 protein BAB76_12330 ENOG4107RN6 Monooxygenase BAB76_12350 ENOG4105CSH Transporter BAB76_12370 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BAB76_12375 ENOG4105CBC glutamate synthase BAB76_12405 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BAB76_12420 ENOG4105CC9 acyl-Coa dehydrogenase BAB76_12435 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB BAB76_12440 ENOG4105CPT Alpha beta hydrolase BAB76_12460 ENOG4105CJP fad dependent oxidoreductase BAB76_12470 ENOG4107QRI Phosphoketolase BAB76_12490 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BAB76_12560 ENOG4105CXN decarboxylase BAB76_12590 ENOG4105CH6 catalase BAB76_12610 ENOG4105C85 amino acid BAB76_12625 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_12645 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) BAB76_12650 ENOG4105DWY Agmatine deiminase BAB76_12670 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BAB76_12730 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) BAB76_12745 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) BAB76_12785 ENOG4105C4B ABC transporter, permease BAB76_12805 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_12810 ENOG4105ERH Fumarylacetoacetate hydrolase BAB76_12825 ENOG4108VWS Yaeq family BAB76_12845 ENOG4106F60 Histidine kinase BAB76_12850 ENOG4105ETX regulatoR BAB76_12875 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BAB76_12880 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAB76_12885 ENOG4105BZU Histidine kinase BAB76_12900 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) BAB76_12945 ENOG410905P Pyridoxamine 5-phosphate BAB76_12950 ENOG4105MXB limonene-12-epoxide hydrolase BAB76_12970 ENOG41082SX arsR family transcriptional regulator BAB76_12990 ENOG4108RZE Tetr family transcriptional regulator BAB76_12995 ENOG4105H3G oxidoreductase BAB76_13005 ENOG4105J5T Amp-dependent synthetase and ligase BAB76_13015 ENOG4105TRI Hydrolase BAB76_13030 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) BAB76_13065 ENOG4108IV0 ABC, transporter BAB76_13070 ENOG4105C0Z ABC transporter BAB76_13075 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BAB76_13080 ENOG4105C32 Amino acid ABC transporter (Permease) BAB76_13105 ENOG4105HMD BAB76_13110 ENOG4105C4M (Ubiquinol oxidase) subunit I BAB76_13115 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BAB76_13120 ENOG4108JJ9 ABC, transporter BAB76_13125 ENOG4108JJ8 (ABC) transporter BAB76_13150 ENOG4105C29 acyl-CoA thioesterase BAB76_13170 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BAB76_13175 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BAB76_13185 ENOG4105DK0 Indole-3-glycerol phosphate synthase BAB76_13195 ENOG4105CRQ synthase (Component I) BAB76_13200 ENOG4105GVJ transcriptional regulator BAB76_13230 ENOG4105CT3 Monooxygenase BAB76_13280 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BAB76_13285 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BAB76_13290 ENOG4108MWI inositol mono-phosphatase BAB76_13295 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BAB76_13300 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BAB76_13305 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BAB76_13310 ENOG4105CIH Imidazole acetol-phosphate transaminase BAB76_13335 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BAB76_13350 ENOG4108RZE Tetr family transcriptional regulator BAB76_13370 ENOG4107YNJ LysR family Transcriptional regulator BAB76_13375 ENOG4105DWT malate dehydrogenase (quinone) BAB76_13385 ENOG41066NP positive regulation by symbiont of host immune response BAB76_13390 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BAB76_13400 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BAB76_13405 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BAB76_13415 ENOG4105EXC Acyl-transferase BAB76_13470 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BAB76_13490 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BAB76_13500 ENOG4108M0I Transcriptional regulator BAB76_13545 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BAB76_13550 ENOG4105CJW magnesium transporter BAB76_13575 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BAB76_13580 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BAB76_13590 ENOG4107QVM von Willebrand factor, type A BAB76_13600 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BAB76_13610 ENOG4105ZXU NLP P60 protein BAB76_13620 ENOG4107QM5 aconitate hydratase BAB76_13625 ENOG4108Q5F Tetr family transcriptional regulator BAB76_13650 ENOG4105C5H ABC transporter BAB76_13665 ENOG41080RH Thioredoxin BAB76_13680 ENOG4108XET gCN5-related N-acetyltransferase BAB76_13690 ENOG4105VG1 fes assembly suf system protein BAB76_13695 ENOG4108UNV SUF system FeS assembly protein, NifU family BAB76_13705 ENOG4105C3K feS assembly ATPase SufC BAB76_13725 ENOG4107JC6 Membrane BAB76_13755 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BAB76_13760 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BAB76_13770 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BAB76_13790 ENOG4106NZI LysR family Transcriptional regulator BAB76_13795 ENOG410846T CoA-transferase family III BAB76_13805 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BAB76_13855 ENOG4105CP7 Triose-phosphate isomerase BAB76_13865 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BAB76_13875 ENOG4105CIE May be required for sporulation (By similarity) BAB76_13885 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BAB76_13890 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BAB76_13915 ENOG4107FQ9 ethanolamine ammonia-lyase BAB76_13920 ENOG4105CPD ethanolamine ammonia-lyase BAB76_13925 ENOG4105CUB amino acid BAB76_13935 ENOG4107RR1 TRANSCRIPTIONal BAB76_13945 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BAB76_13950 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BAB76_13980 ENOG4108UMI ABC transporter, permease BAB76_13985 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BAB76_13990 ENOG4105D01 (LipO)protein BAB76_13995 ENOG4106HTN secreted protease BAB76_14000 ENOG41064B9 (LipO)protein BAB76_14005 ENOG4107UWP Major facilitator superfamily MFS_1 BAB76_14025 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BAB76_14045 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BAB76_14055 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) BAB76_14060 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) BAB76_14070 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BAB76_14080 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) BAB76_14100 ENOG4105SKN orotidine 5''-phosphate decarboxylase BAB76_14105 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BAB76_14110 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BAB76_14125 ENOG4105CXT aspartate transcarbamylase BAB76_14130 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BAB76_14150 ENOG410803B Involved in the transcription termination process (By similarity) BAB76_14155 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BAB76_14160 ENOG4105DC7 peptidase M24 BAB76_14170 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BAB76_14175 ENOG4105D49 3-dehydroquinate synthase BAB76_14180 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BAB76_14185 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BAB76_14195 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) BAB76_14205 ENOG4105URP P-aminobenzoate N-oxygenase AurF BAB76_14210 ENOG4105E2X shikimate dehydrogenase BAB76_14220 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BAB76_14225 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BAB76_14275 ENOG4108PJD permease BAB76_14295 ENOG4105C9M aspartyl-trna synthetase BAB76_14300 ENOG4105EBR Carboxylesterase BAB76_14330 ENOG4105CUT histidyl-tRNA synthetase BAB76_14340 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) BAB76_14350 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BAB76_14355 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BAB76_14360 ENOG4108NY6 Extracellular solute-binding protein, family 5 BAB76_14365 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BAB76_14380 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BAB76_14385 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BAB76_14390 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BAB76_14410 ENOG4105CDY transcriptional regulatory protein BAB76_14420 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BAB76_14425 ENOG4105C29 acyl-CoA thioesterase BAB76_14430 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BAB76_14440 ENOG4105E2K Glycosyl transferase (Group 1 BAB76_14450 ENOG4108VTU Cdp-alcohol phosphatidyltransferase BAB76_14460 ENOG4105C22 threonyL-tRNA synthetase BAB76_14465 ENOG4105ECQ AraC Family Transcriptional Regulator BAB76_14480 ENOG4105PMW Domain of unknown function (DUF1990) BAB76_14515 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BAB76_14520 ENOG4105KME endoribonuclease L-psp BAB76_14560 ENOG4108XI2 Domain of unknown function (DUF1963) BAB76_14620 ENOG4105C7W Xanthine dehydrogenase BAB76_14630 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BAB76_14635 ENOG4107QUY Guanine deaminase BAB76_14655 ENOG4105C2W permease BAB76_14675 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BAB76_14725 ENOG4105E5G Alpha beta hydrolase fold BAB76_14730 ENOG4105C1G acyl-Coa dehydrogenase BAB76_14735 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr BAB76_14750 ENOG4105CHU acetyl-coa acetyltransferase BAB76_14765 ENOG4105D0M Protease HtpX homolog BAB76_14780 ENOG4105C57 major facilitator superfamily BAB76_14830 ENOG4105EJ2 Transcriptional regulator BAB76_14845 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BAB76_14880 ENOG4108P2G integral membrane protein BAB76_14885 ENOG4105E0X reductase BAB76_14910 ENOG4107JTW chlorite dismutase BAB76_14915 ENOG4105C1Q protoporphyrinogen oxidase BAB76_14920 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BAB76_14930 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) BAB76_14940 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BAB76_14945 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BAB76_14950 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BAB76_14955 ENOG4105C0X amino acid BAB76_14960 ENOG4107VEG TrkA-N domain protein BAB76_15005 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BAB76_15050 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BAB76_15100 ENOG4105E18 UPF0276 protein BAB76_15170 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BAB76_15180 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BAB76_15185 ENOG4108Z7F N-acetyltransferase BAB76_15190 ENOG4105C1G acyl-Coa dehydrogenase BAB76_15195 ENOG4108J2R molybdopterin oxidoreductase BAB76_15200 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BAB76_15205 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BAB76_15210 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BAB76_15220 ENOG4105C99 atpase involved in dna repair BAB76_15230 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BAB76_15240 ENOG4105CDA abc transporter atp-binding protein BAB76_15245 ENOG4107UBR Extracellular solute-binding protein family 3 BAB76_15250 ENOG4108Q1T ABC transporter BAB76_15255 ENOG4105DRP amino acid AbC transporter BAB76_15285 ENOG4105KC9 Modulates RecA activity (By similarity) BAB76_15290 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BAB76_15305 ENOG4105MXB limonene-12-epoxide hydrolase BAB76_15310 ENOG4105MXB limonene-12-epoxide hydrolase BAB76_15330 ENOG4105WBV Transcriptional regulator BAB76_15340 ENOG4105CHR reductase BAB76_15405 ENOG4105CN5 Metallo-Beta-Lactamase BAB76_15410 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BAB76_15415 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BAB76_15425 ENOG4105T0Z Conserved Protein BAB76_15440 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BAB76_15475 ENOG4105CHH sulfate transporter BAB76_15485 ENOG4105DCF alanine dehydrogenase BAB76_15495 ENOG4107RN6 Monooxygenase BAB76_15510 ENOG4105C1V Peptidase, M16 BAB76_15515 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BAB76_15525 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BAB76_15565 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BAB76_15595 ENOG4105D2B acyl-CoA dehydrogenase BAB76_15600 ENOG4105D2B acyl-CoA dehydrogenase BAB76_15605 ENOG4105E39 Enoyl-CoA hydratase BAB76_15630 ENOG4105SFS phosphoesterase RecJ domain protein BAB76_15635 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BAB76_15640 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BAB76_15655 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BAB76_15660 ENOG41081JD Transcriptional regulator BAB76_15690 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BAB76_15705 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BAB76_15790 ENOG4105DWT malate dehydrogenase (quinone) BAB76_15810 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BAB76_15845 ENOG4105DZP Membrane-associated zinc metalloprotease BAB76_15870 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BAB76_15880 ENOG4105C3M thioredoxin reductase BAB76_15930 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BAB76_15935 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BAB76_15940 ENOG4105EEM helicase BAB76_15945 ENOG4106Z1T Nicotinamide Mononucleotide Transporter BAB76_15960 ENOG410630P Transcriptional regulator BAB76_15970 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BAB76_15975 ENOG4105CE9 30S ribosomal protein S2 BAB76_15990 ENOG4107MVR Transcriptional regulator BAB76_16010 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BAB76_16030 ENOG4105DND Transcriptional regulator BAB76_16055 ENOG4105C0P Mg chelatase subunit ChlI BAB76_16060 ENOG41080R2 UPF0102 protein BAB76_16100 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BAB76_16110 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BAB76_16120 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BAB76_16125 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BAB76_16135 ENOG4105K5M 30s ribosomal protein S16 BAB76_16180 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) BAB76_16200 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BAB76_16250 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) BAB76_16255 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BAB76_16260 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BAB76_16270 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BAB76_16275 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BAB76_16285 ENOG41087HT growth BAB76_16290 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BAB76_16325 ENOG4106H78 methyltransferase BAB76_16330 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BAB76_16350 ENOG4105DYW oxidoreductase BAB76_16370 ENOG41068W2 Cytochrome p-450 BAB76_16385 ENOG4105CB5 ATP-dependent DNA helicase recG BAB76_16390 ENOG4105DP4 dak2 domain fusion protein ylov BAB76_16400 ENOG4105E39 Enoyl-CoA hydratase BAB76_16410 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BAB76_16425 ENOG4105CPF Cell wall formation (By similarity) BAB76_16430 ENOG4105C28 cystathionine BAB76_16435 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BAB76_16440 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) BAB76_16445 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BAB76_16460 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BAB76_16465 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BAB76_16495 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BAB76_16500 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase BAB76_16515 ENOG4105E5T Major Facilitator Superfamily BAB76_16520 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BAB76_16545 ENOG4105EGI Transcriptional regulator BAB76_16555 ENOG4108RCM Nitroreductase BAB76_16570 ENOG4108RZE Tetr family transcriptional regulator BAB76_16585 ENOG4106A3M Cytochrome p-450 BAB76_16610 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BAB76_16615 ENOG4108ZP8 Acetolactate synthase small subunit BAB76_16630 ENOG4105E3Q saccharopine dehydrogenase BAB76_16635 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BAB76_16675 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BAB76_16685 ENOG4105EBR Carboxylesterase BAB76_16700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAB76_16705 ENOG4105EB3 Histidine kinase BAB76_16715 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BAB76_16720 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BAB76_16730 ENOG4105EDW glycosyl transferase, family 39 BAB76_16735 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BAB76_16755 ENOG4106HTN secreted protease BAB76_16760 ENOG4105E39 Enoyl-CoA hydratase BAB76_16765 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase BAB76_16775 ENOG4105C7N Xanthine uracil vitamin C permease BAB76_16790 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BAB76_16815 ENOG4105WH1 Two component transcriptional regulator luxr family BAB76_16820 ENOG4105C10 Electron transfer flavoprotein BAB76_16830 ENOG4108KQJ Type 11 methyltransferase BAB76_16850 ENOG4105EW9 transcriptional regulator AsnC family BAB76_16855 ENOG4108UMN azlc family BAB76_16870 ENOG4108JGH Tetr family transcriptional regulator BAB76_16900 ENOG4105EVB acetyltransferase BAB76_16905 ENOG4108V0V Pyrrolo-quinoline quinone BAB76_16930 ENOG4105DKW ABC transporter BAB76_16940 ENOG4108VW9 Membrane BAB76_16945 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BAB76_17010 ENOG4105DQ4 alcohol dehydrogenase BAB76_17030 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BAB76_17035 ENOG4105CHR reductase BAB76_17055 ENOG4105C5Q Transcriptional regulator BAB76_17085 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BAB76_17095 ENOG4105CSH Transporter BAB76_17110 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BAB76_17115 ENOG4105CHR reductase BAB76_17145 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BAB76_17170 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BAB76_17180 ENOG4107ZR7 Membrane BAB76_17190 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_17200 ENOG4108IG5 Transcriptional regulator BAB76_17215 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr BAB76_17220 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BAB76_17270 ENOG41082VC UPF0145 protein BAB76_17275 ENOG4105EBR Carboxylesterase BAB76_17280 ENOG4105EBR Carboxylesterase BAB76_17290 ENOG4105CHU acetyl-coa acetyltransferase BAB76_17295 ENOG4107YPT transcriptional regulator BAB76_17325 ENOG4108JGH Tetr family transcriptional regulator BAB76_17350 ENOG4105KNI merR family transcriptional Regulator BAB76_17525 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BAB76_17745 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BAB76_17760 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BAB76_17765 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) BAB76_17770 ENOG4105CAK Cell division ATP-binding protein ftsE BAB76_17780 ENOG4105D8X mechanosensitive ion channel BAB76_17785 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BAB76_17820 ENOG4107TK4 histidinol-phosphate phosphatase BAB76_17825 ENOG4105C1G acyl-Coa dehydrogenase BAB76_17830 ENOG4105C1G acyl-Coa dehydrogenase BAB76_17845 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_17855 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BAB76_17895 ENOG4105DJZ UPF0182 protein BAB76_17900 ENOG41063PX domain protein BAB76_17905 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BAB76_17920 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BAB76_17925 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BAB76_17935 ENOG4107FW0 short-chain dehydrogenase reductase BAB76_17945 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BAB76_17975 ENOG4105CKD glutathione-regulated potassium-efflux system protein BAB76_17990 ENOG4108YIQ Alpha beta hydrolase BAB76_18005 ENOG4108KXV response regulator BAB76_18015 ENOG4107QZF nitrite reductase NADPH large subunit BAB76_18020 ENOG4105DQQ Major facilitator superfamily MFS_1 BAB76_18060 ENOG4105C1J atp-dependent rna helicase BAB76_18075 ENOG4108ZM9 phosphoglycerate mutase BAB76_18095 ENOG4107TE5 Lipid kinase BAB76_18110 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BAB76_18120 ENOG4105EMN RNA polymerase sigma factor BAB76_18125 ENOG4108Z66 YbaK ebsC protein BAB76_18130 ENOG4108RAV Conserved protein BAB76_18135 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BAB76_18140 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BAB76_18170 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) BAB76_18175 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BAB76_18255 ENOG4105C7S Dehydrogenase BAB76_18270 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BAB76_18275 ENOG4108JA1 polyketide synthase BAB76_18285 ENOG4105C1G acyl-Coa dehydrogenase BAB76_18295 ENOG4107RCI amp-dependent synthetase and ligase BAB76_18300 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BAB76_18315 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea BAB76_18325 ENOG4108RZE Tetr family transcriptional regulator BAB76_18340 ENOG4108T3R lipoprotein lpqB BAB76_18345 ENOG4105BZU Histidine kinase BAB76_18355 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_18370 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) BAB76_18380 ENOG4105VCQ rubredoxin BAB76_18385 ENOG41084UD rubredoxin BAB76_18390 ENOG4105EEF Alkane 1-monooxygenase BAB76_18395 ENOG4105CUB amino acid BAB76_18405 ENOG4105EIP mannose-6-phosphate isomerase BAB76_18430 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BAB76_18435 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase BAB76_18440 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) BAB76_18470 ENOG4107TB5 TRANSCRIPTIONal BAB76_18490 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BAB76_18500 ENOG4105E2B Taurine dioxygenase BAB76_18505 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BAB76_18525 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BAB76_18535 ENOG4105J5T Amp-dependent synthetase and ligase BAB76_18550 ENOG4105D8K carboxyl transferase BAB76_18560 ENOG4107WR6 Maf-like protein BAB76_18565 ENOG4105C6Z Gluconate BAB76_18570 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family BAB76_18575 ENOG4105C1G acyl-Coa dehydrogenase BAB76_18590 ENOG4105DEN Luciferase family BAB76_18610 ENOG4108JIK carboxylase BAB76_18620 ENOG4107XM5 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BAB76_18640 ENOG4105C26 Dehydrogenase BAB76_18650 ENOG4107QRT dEAD DEAH box helicase BAB76_18665 ENOG4105D3G Pseudouridine synthase BAB76_18685 ENOG4107RM1 amidohydrolase BAB76_18700 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain BAB76_18705 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BAB76_18715 ENOG4105ZXU NLP P60 protein BAB76_18745 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BAB76_18775 ENOG4105E33 succinate dehydrogenase BAB76_18780 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BAB76_18785 ENOG4108KPJ rna polymerase sigma factor BAB76_18800 ENOG4105DZ1 carboxypeptidase BAB76_18815 ENOG4105CGK Exodeoxyribonuclease III BAB76_18825 ENOG4105E9K Isocitrate dehydrogenase BAB76_18855 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BAB76_18865 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BAB76_18875 ENOG4105KVH Transcriptional regulator BAB76_18880 ENOG4108RYK Nad-dependent epimerase dehydratase BAB76_18885 ENOG4105IDI abc transporter atp-binding protein BAB76_18890 ENOG4107Z6C Pentapeptide repeat-containing protein BAB76_18905 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BAB76_18910 ENOG4105C0B DNA polymerase III (alpha subunit) BAB76_18915 ENOG4105ENX hydrolase BAB76_18985 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BAB76_18995 ENOG4107QVP Dehydrogenase BAB76_19005 ENOG4108VT4 BAB76_19025 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BAB76_19050 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BAB76_19055 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BAB76_19065 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BAB76_19070 ENOG41080E2 ribosomal-protein-alanine acetyltransferase BAB76_19095 ENOG4105CVK Glutamate decarboxylase BAB76_19105 ENOG4108JNI Alpha beta hydrolase BAB76_19110 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BAB76_19135 ENOG4105DYW oxidoreductase BAB76_19145 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BAB76_19150 ENOG4108UJD 30S ribosomal protein S9 BAB76_19155 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BAB76_19185 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin BAB76_19215 ENOG4105D74 hydrolase BAB76_19240 ENOG4108ZT0 50S ribosomal protein l17 BAB76_19245 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BAB76_19250 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BAB76_19255 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BAB76_19260 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BAB76_19265 ENOG41067V7 50S ribosomal protein L36 BAB76_19285 ENOG4105DZ6 Band 7 protein BAB76_19295 ENOG4105C1B dTDP-glucose 4-6-dehydratase BAB76_19300 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BAB76_19315 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BAB76_19335 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) BAB76_19360 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BAB76_19365 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BAB76_19370 ENOG410849U 50S ribosomal protein L30 BAB76_19375 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BAB76_19380 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BAB76_19385 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BAB76_19390 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BAB76_19400 ENOG4105D82 Glutamate dehydrogenase BAB76_19415 ENOG4105EBR Carboxylesterase BAB76_19420 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BAB76_19425 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BAB76_19430 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BAB76_19435 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BAB76_19440 ENOG4105CSH Transporter BAB76_19455 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BAB76_19460 ENOG41082SA 50s ribosomal protein l29 BAB76_19465 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BAB76_19470 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BAB76_19475 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BAB76_19480 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BAB76_19485 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BAB76_19490 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BAB76_19495 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BAB76_19500 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BAB76_19685 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BAB76_19830 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BAB76_19850 ENOG4107FQ9 ethanolamine ammonia-lyase BAB76_19855 ENOG4105CPD ethanolamine ammonia-lyase BAB76_19860 ENOG4105CUB amino acid BAB76_19865 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) BAB76_19890 ENOG4105XDV BAB76_19915 ENOG4105CIK Amidinotransferase BAB76_19920 ENOG4105C8Y Acetylornithine aminotransferase BAB76_19925 ENOG4105CUB amino acid BAB76_19955 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BAB76_19960 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BAB76_19965 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BAB76_20000 ENOG4105E39 Enoyl-CoA hydratase BAB76_20015 ENOG4105CSU acyl-Coa dehydrogenase BAB76_20045 ENOG4105C85 amino acid BAB76_20055 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BAB76_20060 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BAB76_20065 ENOG4107QY8 reductase BAB76_20095 ENOG41082SK Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BAB76_20100 ENOG4108VZM 50s ribosomal protein L10 BAB76_20105 ENOG4107UB2 Alpha beta hydrolase fold BAB76_20155 ENOG4105CHP RNA polymerase BAB76_20175 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BAB76_20180 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BAB76_20215 ENOG4105WDJ 50S ribosomal protein L33 BAB76_20230 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction BAB76_20235 ENOG4108Z0Z intracellular protease Pfpi family BAB76_20280 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BAB76_20385 ENOG4108VPT UPF0234 protein BAB76_20390 ENOG410829K Lysine exporter protein (Lyse ygga) BAB76_20425 ENOG4107RN6 Monooxygenase BAB76_20460 ENOG4105D0M Protease HtpX homolog BAB76_20470 ENOG4105P52 geranylgeranyl reductase BAB76_20475 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BAB76_20490 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BAB76_20500 ENOG4107TCW O-succinylbenzoate synthase BAB76_20525 ENOG4105BZU Histidine kinase BAB76_20530 ENOG4105EUB pirin domain protein BAB76_20540 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BAB76_20550 ENOG4107SIQ Naphthoate synthase BAB76_20555 ENOG4108BAS reductase BAB76_20560 ENOG4105PDP Short chain dehydrogenase BAB76_20605 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) BAB76_20695 ENOG4105CRE cytochrome C BAB76_20700 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) BAB76_20705 ENOG4107QIV Cytochrome c biogenesis protein BAB76_20715 ENOG4108RH7 phosphoglycerate mutase BAB76_20720 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BAB76_20735 ENOG4105C9K Endothelin-converting enzyme 1 BAB76_20785 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BAB76_20790 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BAB76_20795 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BAB76_20805 ENOG4108RXW HAD-superfamily subfamily IB hydrolase BAB76_20810 ENOG410900P UPF0336 protein BAB76_20835 ENOG4105EA8 2-Nitropropane dioxygenase BAB76_20855 ENOG4105II7 pyrroline-5-carboxylate reductase BAB76_20865 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta BAB76_20890 ENOG41063NU Membrane BAB76_20890 ENOG41063NU Membrane BAB76_20915 ENOG4107RN6 Monooxygenase BAB76_20950 ENOG4105F95 Monooxygenase BAB76_20965 ENOG41082JN Transcriptional regulator BAB76_21025 ENOG4105F95 Monooxygenase BAB76_21040 ENOG4105F95 Monooxygenase BAB76_21065 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAB76_21070 ENOG4105BZU Histidine kinase BAB76_21080 ENOG4105F95 Monooxygenase BAB76_21095 ENOG4105E0T Short-chain dehydrogenase reductase Sdr BAB76_21105 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_21110 ENOG4108YZJ Pfam:DUF2596 BAB76_21115 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BAB76_21230 ENOG4105TT9 Protein of unknown function (DUF2516) BAB76_21235 ENOG4105V9F hemagglutinin BAB76_21245 ENOG4106BRA Membrane BAB76_21255 ENOG4105CSR polyphosphate kinase 2 BAB76_21260 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BAB76_21295 ENOG4107RPH Isocitrate lyase BAB76_21335 ENOG4108YRB methyltransferase BAB76_21385 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BAB76_21420 ENOG4105CPC Aldo Keto reductase BAB76_21435 ENOG4107T8P acyl-Coa dehydrogenase BAB76_21445 ENOG4105CPU Monooxygenase BAB76_21490 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 BAB76_21495 ENOG4105CSR polyphosphate kinase 2 BAB76_21510 ENOG4106UW1 Major Facilitator superfamily BAB76_21515 ENOG41082BM Transcriptional regulator, arsr family BAB76_21545 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase BAB76_21600 ENOG4105CHR reductase BAB76_21610 ENOG4105X7H acyl-CoA dehydrogenase BAB76_21615 ENOG4108KC2 acyl-Coa dehydrogenase BAB76_21620 ENOG4105J5T Amp-dependent synthetase and ligase BAB76_21640 ENOG4105E39 Enoyl-CoA hydratase BAB76_21650 ENOG4105DYW oxidoreductase BAB76_21680 ENOG4108Z0R Transferase BAB76_21685 ENOG4105CIJ rieske 2fe-2S domain-containing protein BAB76_21695 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BAB76_21725 ENOG4105C11 sulfate adenylyltransferase), subunit 2 BAB76_21735 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) BAB76_21755 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BAB76_21760 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BAB76_21795 ENOG4105C0R drug resistance transporter emrb qaca subfamily BAB76_21800 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BAB76_21825 ENOG4108SGK Tetr family transcriptional regulator BAB76_21835 ENOG4105C26 Dehydrogenase BAB76_21850 ENOG4105D5Q Arginine ornithine antiporter BAB76_21880 ENOG4105IIU Aminopeptidase BAB76_21885 ENOG4105IIU Aminopeptidase BAB76_21895 ENOG4105CJ1 ABC, transporter BAB76_21900 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BAB76_21935 ENOG4105CT1 (ABC) transporter BAB76_21940 ENOG4107Q25 Serine Threonine protein kinase BAB76_21945 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BAB76_21970 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BAB76_21980 ENOG4105CPU Monooxygenase BAB76_21985 ENOG4105DEN Luciferase family BAB76_21990 ENOG4105CPU Monooxygenase BAB76_22000 ENOG4105EAB amino acid AbC transporter BAB76_22005 ENOG4105CDA abc transporter atp-binding protein BAB76_22045 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BAB76_22065 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BAB76_22075 ENOG4107XZ0 Peptidase M50 BAB76_22095 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN BAB76_22125 ENOG4105EMU Dehydrogenase BAB76_22145 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BAB76_22170 ENOG4105KNI merR family transcriptional Regulator BAB76_22175 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BAB76_22180 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BAB76_22185 ENOG4105CFG Acts as a chaperone (By similarity) BAB76_22250 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BAB76_22290 ENOG4105DF6 Fe-S oxidoreductase BAB76_22300 ENOG4105C6Y Udp-glucose 6-dehydrogenase BAB76_22310 ENOG4105DHP deoxycytidine triphosphate deaminase BAB76_22340 ENOG4105EX0 alpha-galactosidase BAB76_22345 ENOG4105E6M Sulphatase-modifying factor protein BAB76_22355 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) BAB76_22435 ENOG4105C26 Dehydrogenase BAB76_22440 ENOG4105D5Q Arginine ornithine antiporter BAB76_22445 ENOG4108XSB acetyltransferase, (GNAT) family BAB76_22465 ENOG4105IIV Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) BAB76_22480 ENOG4107XDR Lactoylglutathione lyase BAB76_22500 ENOG4105CHR reductase BAB76_22505 ENOG4105D2B acyl-CoA dehydrogenase BAB76_22520 ENOG4105EG6 Saccharopine dehydrogenase BAB76_22525 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_22530 ENOG4105DQE DNA ligase BAB76_22535 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BAB76_22545 ENOG4105C7I Dehydrogenase BAB76_22550 ENOG4108JPW Aminotransferase BAB76_22555 ENOG4105C26 Dehydrogenase BAB76_22585 ENOG4108XG4 DNA-binding transcriptional regulator BAB76_22595 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) BAB76_22600 ENOG4105ERH Fumarylacetoacetate hydrolase BAB76_22625 ENOG4105ERH Fumarylacetoacetate hydrolase BAB76_22630 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_22655 ENOG41088PD hydrolase BAB76_22675 ENOG4105FUY alpha subunit BAB76_22685 ENOG4105DP7 Protocatechuate 4,5-dioxygenase BAB76_22690 ENOG4105IKQ hydratase BAB76_22695 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) BAB76_22700 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) BAB76_22705 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BAB76_22710 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_22745 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) BAB76_22750 ENOG4108DMA Nad-dependent epimerase dehydratase BAB76_22775 ENOG4108HUF Transporter BAB76_22790 ENOG4105P4J Allophanate hydrolase, subunit 1 BAB76_22795 ENOG4107R7A Allophanate hydrolase subunit 2 BAB76_22855 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BAB76_22865 ENOG4105C5Q Transcriptional regulator BAB76_22870 ENOG4105CR4 methylisocitrate lyase BAB76_22875 ENOG4105G3Z GntR family transcriptional regulator BAB76_22895 ENOG4105DV0 amidase (EC 3.5.1.4 BAB76_22905 ENOG4108JPW Aminotransferase BAB76_22915 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BAB76_22930 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) BAB76_22950 ENOG4105MHT Transcriptional regulator, ARSR family BAB76_22960 ENOG4105CHR reductase BAB76_23005 ENOG4105CSU acyl-Coa dehydrogenase BAB76_23020 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BAB76_23030 ENOG4105CHU acetyl-coa acetyltransferase BAB76_23035 ENOG4105CHR reductase BAB76_23050 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BAB76_23055 ENOG4105CHH sulfate transporter BAB76_23060 ENOG4107Z3H Transcriptional regulator, TetR family BAB76_23065 ENOG4105EE5 Membrane protein terC BAB76_23105 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) BAB76_23110 ENOG4105CHP RNA polymerase BAB76_23160 ENOG4105CBG Sulfatase BAB76_23175 ENOG41073B4 coagulation factor 5 8 type domain-containing protein BAB76_23190 ENOG4107RN6 Monooxygenase BAB76_23210 ENOG4108I69 Glycosyl transferases group 1 BAB76_23215 ENOG4108M6P methyltransferase BAB76_23255 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BAB76_23300 ENOG4105WH1 Two component transcriptional regulator luxr family BAB76_23305 ENOG4105BZU Histidine kinase BAB76_23310 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BAB76_23325 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) BAB76_23355 ENOG4107R13 MMPL domain protein BAB76_23400 ENOG4105CY3 ABC transporter, permease BAB76_23410 ENOG4105WH1 Two component transcriptional regulator luxr family BAB76_23440 ENOG4108YYC ycei family BAB76_23460 ENOG4107WA4 MmpL domain-containing protein BAB76_23480 ENOG4105K4P CoA-binding domain protein BAB76_23495 ENOG4105C9K Endothelin-converting enzyme 1 BAB76_23500 ENOG4105S7A ErfK ybiS ycfS ynhG family protein BAB76_23505 ENOG4105C1G acyl-Coa dehydrogenase BAB76_23515 ENOG4107QX3 carboxylase BAB76_23525 ENOG4105VPX protein, conserved in bacteria BAB76_23540 ENOG4105C01 Dihydroxy-acid dehydratase BAB76_23550 ENOG4105C26 Dehydrogenase BAB76_23570 ENOG4105E5G Alpha beta hydrolase fold BAB76_23600 ENOG4108V0P LemA family BAB76_23610 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_23665 ENOG4105CGU Enoyl-CoA hydratase BAB76_23670 ENOG4108WYP Transcriptional regulator BAB76_23680 ENOG4105D74 hydrolase BAB76_23685 ENOG4108R86 Transcriptional regulator BAB76_23700 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BAB76_23705 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BAB76_23710 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BAB76_23715 ENOG4105CHF Glutathione S-transferase BAB76_23735 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) BAB76_23740 ENOG4108XZR Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) BAB76_23755 ENOG4106YT9 Enoyl-CoA hydratase BAB76_23765 ENOG4105EAA nucleoside BAB76_23835 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr BAB76_23840 ENOG4105C26 Dehydrogenase BAB76_23845 ENOG4108UGJ Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) BAB76_23850 ENOG4108XB2 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) BAB76_23855 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BAB76_23860 ENOG4105C1G acyl-Coa dehydrogenase BAB76_23880 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BAB76_23895 ENOG4105CFF transcriptional regulator BAB76_23905 ENOG4105CR4 methylisocitrate lyase BAB76_23910 ENOG4105BZN citrate synthase BAB76_23945 ENOG4105CEY Amp-dependent synthetase and ligase BAB76_24005 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BAB76_24015 ENOG4105C01 Dihydroxy-acid dehydratase BAB76_24030 ENOG4105DV0 amidase (EC 3.5.1.4 BAB76_24035 ENOG4105JXH GntR family transcriptional regulator BAB76_24065 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BAB76_24070 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BAB76_24100 ENOG4105CHR reductase BAB76_24140 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BAB76_24155 ENOG4107RCI amp-dependent synthetase and ligase BAB76_24160 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BAB76_24165 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BAB76_24175 ENOG4107QI6 Cysteine desulfurase BAB76_24190 ENOG4107QX3 carboxylase BAB76_24235 ENOG4107Z3H Transcriptional regulator, TetR family BAB76_24290 ENOG4107EMZ glycosyl transferase family BAB76_24400 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) BAB76_24460 ENOG4105DHU Bile acid BAB76_24480 ENOG4108KPJ rna polymerase sigma factor BAB76_24490 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction BAB76_24505 ENOG4105CH2 amidohydrolase BAB76_24530 ENOG4105CEP NADH dehydrogenase BAB76_24550 ENOG4105VPX protein, conserved in bacteria BAB76_24650 ENOG4105F0F Oxalate decarboxylase BAB76_24675 ENOG4108QER Adenylate cyclase BAB76_24695 ENOG41069FZ L,D-transpeptidase catalytic domain BAB76_24705 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) BAB76_24715 ENOG410900P UPF0336 protein BAB76_24720 ENOG4105C5H ABC transporter BAB76_24725 ENOG4108WKN secreted protein BAB76_24790 ENOG4105DND Transcriptional regulator BAB76_24815 ENOG4107QK9 Beta-lactamase BAB76_24820 ENOG4108WKN secreted protein BAB76_25055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BAB76_25060 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BAB76_25075 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) BAB76_25125 ENOG41082BM Transcriptional regulator, arsr family BAB76_25140 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BAB76_25150 ENOG4105DHP deoxycytidine triphosphate deaminase BAB76_25185 ENOG4108KU9 integrase family BAB76_25190 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BAB76_25225 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BAB76_25260 ENOG4105I4A GCN5-related N-acetyltransferase BAB76_25295 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BAB76_25300 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BAB76_25305 ENOG4107YH6 single-stranded DNA-binding protein BAB76_25310 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) BAB76_25320 ENOG4105BZ4 penicillin-binding protein BAB76_25350 ENOG4105CZA synthase BAB76_25360 ENOG4105C85 amino acid BAB76_25375 ENOG4108RZE Tetr family transcriptional regulator BAB76_25380 ENOG4105CHR reductase BAB76_25395 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 BAB76_25400 ENOG4105CPP Dehydrogenase, E1 component BAB76_25420 ENOG4105DHF Membrane BAB76_25430 ENOG4105C8T Leucyl-tRNA synthetase BAB76_25435 ENOG41064CH Probable lipoprotein LpqN BAB76_25455 ENOG41081DT UPF0301 protein BAB76_25460 ENOG4108M0D major facilitator superfamily BAB76_25485 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BAB76_25515 ENOG4105C3M thioredoxin reductase BAB76_25525 ENOG4108E1C hydrolase BAB76_25545 ENOG4107Z3H Transcriptional regulator, TetR family BAB76_25560 ENOG4107QJE Chromosome Partitioning Protein BAB76_25565 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BAB76_25575 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BAB76_25590 ENOG41084CH 50S ribosomal protein l34