locus-tag	class	description
I3U39_00015	COG0592	DNA-directed DNA polymerase activity
I3U39_00020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I3U39_00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I3U39_00030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I3U39_00035	COG0187	DNA topoisomerase II activity
I3U39_00215	COG2217	Heavy metal translocating P-type atpase
I3U39_00225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3U39_00315	COG0640	Transcriptional regulator
I3U39_00345	COG2132	Multicopper oxidase
I3U39_00380	COG0596	Alpha beta hydrolase
I3U39_00400	COG0583	DNA-binding transcription factor activity
I3U39_00415	COG0457	Tetratricopeptide repeat
I3U39_00415	COG0705	Rhomboid family
I3U39_00445	COG2815	serine threonine protein kinase
I3U39_00445	COG0515	serine threonine protein kinase
I3U39_00450	COG0515	serine threonine protein kinase
I3U39_00455	COG0768	penicillin binding
I3U39_00470	COG1716	ATPase activity
I3U39_00475	COG1716	ATPase activity
I3U39_00485	COG1309	transcriptional regulator
I3U39_00500	COG0604	alcohol dehydrogenase
I3U39_00500	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_00500	COG3321	synthase
I3U39_00560	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_00570	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_00575	COG2130	NADP-dependent
I3U39_00620	COG1309	transcriptional regulator
I3U39_00640	COG4842	Belongs to the WXG100 family
I3U39_00660	COG0590	tRNA wobble adenosine to inosine editing
I3U39_00670	COG0583	DNA-binding transcription factor activity
I3U39_00675	COG1643	Atp-dependent helicase
I3U39_00680	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_00700	COG4585	Histidine kinase
I3U39_00720	COG1960	acyl-CoA dehydrogenase activity
I3U39_00765	COG2072	flavoprotein involved in K transport
I3U39_00775	COG0346	lactoylglutathione lyase activity
I3U39_00780	COG1414	Transcriptional regulator
I3U39_00800	COG1053	succinate dehydrogenase
I3U39_00830	COG1785	Belongs to the alkaline phosphatase family
I3U39_00850	COG0069	glutamate synthase activity
I3U39_00850	COG0067	glutamate synthase
I3U39_00850	COG0070	glutamate synthase
I3U39_00910	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I3U39_00910	COG1796	DNA polymerase
I3U39_00920	COG2072	flavoprotein involved in K transport
I3U39_00930	COG2124	cytochrome p450
I3U39_00945	COG1024	Enoyl-CoA hydratase
I3U39_00975	COG2372	response to copper ion
I3U39_01025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3U39_01045	COG5001	Diguanylate cyclase
I3U39_01045	COG5002	protein histidine kinase activity
I3U39_01045	COG3447	MASE1 domain protein
I3U39_01055	COG1528	Iron-storage protein
I3U39_01060	COG1528	Iron-storage protein
I3U39_01065	COG1316	TRANSCRIPTIONal
I3U39_01090	COG0406	alpha-ribazole phosphatase activity
I3U39_01100	COG0028	Belongs to the TPP enzyme family
I3U39_01125	COG2072	flavoprotein involved in K transport
I3U39_01135	COG2072	flavoprotein involved in K transport
I3U39_01145	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_01155	COG1285	pathogenesis
I3U39_01205	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3U39_01205	COG2146	nitrite reductase [NAD(P)H] activity
I3U39_01215	COG4133	protoheme IX ABC transporter activity
I3U39_01220	COG2070	2-Nitropropane dioxygenase
I3U39_01225	COG1942	4-Oxalocrotonate Tautomerase
I3U39_01230	COG0583	DNA-binding transcription factor activity
I3U39_01245	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_01260	COG0561	phosphatase activity
I3U39_01280	COG1216	Glycosyl transferase, family 2
I3U39_01285	COG0671	phosphoesterase, PA-phosphatase related
I3U39_01290	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3U39_01295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3U39_01315	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I3U39_01320	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_01325	COG3321	synthase
I3U39_01325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3U39_01325	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I3U39_01330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U39_01380	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_01385	COG0277	FAD linked oxidase domain protein
I3U39_01395	COG2376	Dihydroxyacetone kinase
I3U39_01400	COG2267	carboxylic ester hydrolase activity
I3U39_01405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3U39_01410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3U39_01425	COG0671	phosphoesterase, PA-phosphatase related
I3U39_01435	COG1216	Glycosyl transferase, family 2
I3U39_01630	COG0789	Transcriptional regulator
I3U39_01725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3U39_01730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3U39_01800	COG1960	acyl-CoA dehydrogenase activity
I3U39_01820	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_01840	COG1174	glycine betaine transport
I3U39_01855	COG0287	Prephenate dehydrogenase
I3U39_01865	COG0590	tRNA wobble adenosine to inosine editing
I3U39_01890	COG0343	queuine tRNA-ribosyltransferase activity
I3U39_01900	COG0765	amino acid transport
I3U39_01905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I3U39_01910	COG1793	dna ligase
I3U39_01940	COG2271	Major facilitator Superfamily
I3U39_01945	COG2130	NADP-dependent
I3U39_01970	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3U39_01995	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_02045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3U39_02070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3U39_02080	COG0148	phosphopyruvate hydratase activity
I3U39_02110	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3U39_02135	COG1492	cobalamin metabolic process
I3U39_02160	COG1960	acyl-CoA dehydrogenase activity
I3U39_02175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I3U39_02205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3U39_02225	COG1231	oxidoreductase activity
I3U39_02255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3U39_02265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3U39_02295	COG2070	2-Nitropropane dioxygenase
I3U39_02340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3U39_02345	COG2971	BadF BadG BcrA BcrD
I3U39_02350	COG2814	Major facilitator Superfamily
I3U39_02370	COG3572	ergothioneine biosynthetic process
I3U39_02375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3U39_02380	COG0121	glutamine amidotransferase
I3U39_02385	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I3U39_02390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3U39_02415	COG0183	Belongs to the thiolase family
I3U39_02420	COG2030	dehydratase
I3U39_02425	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_02430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3U39_02440	COG1695	Transcriptional regulator
I3U39_02450	COG0475	glutathione-regulated potassium exporter activity
I3U39_02450	COG0569	domain protein
I3U39_02470	COG0714	Associated with various cellular activities
I3U39_02515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3U39_02520	COG1074	ATP-dependent DNA helicase activity
I3U39_02525	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I3U39_02535	COG2755	lipolytic protein G-D-S-L family
I3U39_02640	COG4974	Belongs to the 'phage' integrase family
I3U39_02650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3U39_02655	COG1408	metallophosphoesterase
I3U39_02660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I3U39_02690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3U39_02730	COG0596	Alpha beta hydrolase
I3U39_02730	COG2945	thiolester hydrolase activity
I3U39_02745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3U39_02750	COG0747	negative chemotaxis
I3U39_02760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3U39_02820	COG2814	Major facilitator Superfamily
I3U39_02825	COG1595	DNA-templated transcription, initiation
I3U39_02835	COG0667	Aldo Keto reductase
I3U39_02845	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I3U39_02855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3U39_02885	COG2188	Transcriptional regulator
I3U39_02890	COG2079	MmgE PrpD family protein
I3U39_02900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I3U39_02905	COG0066	3-isopropylmalate dehydratase activity
I3U39_02980	COG0582	viral genome integration into host DNA
I3U39_02995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3U39_03035	COG1061	Type III restriction enzyme res subunit
I3U39_03050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U39_03070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U39_03085	COG0183	Belongs to the thiolase family
I3U39_03105	COG0657	acetylesterase activity
I3U39_03110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U39_03155	COG1024	Enoyl-CoA hydratase
I3U39_03170	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_03185	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_03190	COG0657	acetylesterase activity
I3U39_03200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U39_03205	COG1012	belongs to the aldehyde dehydrogenase family
I3U39_03210	COG1960	acyl-CoA dehydrogenase activity
I3U39_03215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3U39_03220	COG2902	Dehydrogenase
I3U39_03225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U39_03235	COG1012	belongs to the aldehyde dehydrogenase family
I3U39_03240	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I3U39_03245	COG0531	amino acid
I3U39_03265	COG0436	Aminotransferase
I3U39_03270	COG5651	PPE family
I3U39_03475	COG2814	Major facilitator Superfamily
I3U39_03480	COG0442	prolyl-tRNA aminoacylation
I3U39_03500	COG0697	spore germination
I3U39_03525	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3U39_03580	COG0604	alcohol dehydrogenase
I3U39_03585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3U39_03590	COG0581	inorganic phosphate transmembrane transporter activity
I3U39_03610	COG0745	RESPONSE REGULATOR receiver
I3U39_03630	COG2897	thiosulfate sulfurtransferase activity
I3U39_03690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I3U39_03725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3U39_03730	COG0601	transmembrane transport
I3U39_03740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3U39_03825	COG2837	iron assimilation
I3U39_03840	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3U39_03850	COG3573	Dehydrogenase
I3U39_03860	COG0386	Belongs to the glutathione peroxidase family
I3U39_03865	COG0477	Major facilitator Superfamily
I3U39_03890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3U39_03900	COG0436	Aminotransferase
I3U39_03930	COG0596	Alpha beta hydrolase
I3U39_03940	COG0697	spore germination
I3U39_03945	COG0537	adenosine 5'-monophosphoramidase activity
I3U39_03950	COG5000	phosphorelay sensor kinase activity
I3U39_03950	COG5002	protein histidine kinase activity
I3U39_03955	COG0745	RESPONSE REGULATOR receiver
I3U39_04000	COG4842	Belongs to the WXG100 family
I3U39_04015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U39_04065	COG0714	Associated with various cellular activities
I3U39_04080	COG0459	protein refolding
I3U39_04100	COG4221	oxidoreductase activity
I3U39_04125	COG0647	UMP catabolic process
I3U39_04145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3U39_04160	COG2111	Na H antiporter
I3U39_04160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3U39_04170	COG0651	ATP synthesis coupled electron transport
I3U39_04205	COG1674	ftsk spoiiie
I3U39_04215	COG1404	Belongs to the peptidase S8 family
I3U39_04225	COG0464	growth
I3U39_04355	COG3971	2-oxopent-4-enoate hydratase activity
I3U39_04365	COG1053	succinate dehydrogenase
I3U39_04370	COG2030	dehydratase
I3U39_04395	COG2030	dehydratase
I3U39_04400	COG1960	acyl-CoA dehydrogenase activity
I3U39_04405	COG1960	acyl-CoA dehydrogenase activity
I3U39_04415	COG0183	Belongs to the thiolase family
I3U39_04435	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_04440	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_04445	COG1024	Enoyl-CoA hydratase
I3U39_04475	COG0183	Belongs to the thiolase family
I3U39_04490	COG1960	acyl-CoA dehydrogenase activity
I3U39_04495	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_04500	COG1960	acyl-CoA dehydrogenase activity
I3U39_04505	COG1960	acyl-CoA dehydrogenase activity
I3U39_04510	COG1960	acyl-CoA dehydrogenase activity
I3U39_04550	COG0346	lactoylglutathione lyase activity
I3U39_04560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3U39_04575	COG1960	acyl-CoA dehydrogenase activity
I3U39_04580	COG1309	transcriptional regulator
I3U39_04590	COG0803	Belongs to the bacterial solute-binding protein 9 family
I3U39_04595	COG1120	ATPase activity
I3U39_04600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3U39_04610	COG0584	glycerophosphoryl diester phosphodiesterase
I3U39_04620	COG0215	cysteine-tRNA ligase activity
I3U39_04630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I3U39_04635	COG1329	Transcriptional regulator
I3U39_04655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I3U39_04665	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I3U39_04675	COG1316	TRANSCRIPTIONal
I3U39_04685	COG1194	a g-specific adenine glycosylase
I3U39_04690	COG4977	sequence-specific DNA binding
I3U39_04730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3U39_04735	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I3U39_04755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I3U39_04765	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I3U39_04810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3U39_04825	COG1309	transcriptional regulator
I3U39_04835	COG2267	carboxylic ester hydrolase activity
I3U39_04845	COG1063	alcohol dehydrogenase
I3U39_04880	COG2027	D-alanyl-D-alanine carboxypeptidase
I3U39_04915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3U39_05025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I3U39_05035	COG1754	DNA topoisomerase type I activity
I3U39_05035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3U39_05045	COG1278	Cold shock
I3U39_05050	COG1111	helicase
I3U39_05050	COG1205	dead DEAH box helicase
I3U39_05055	COG1902	pentaerythritol trinitrate reductase activity
I3U39_05060	COG0657	acetylesterase activity
I3U39_05065	COG1309	transcriptional regulator
I3U39_05070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U39_05140	COG0582	viral genome integration into host DNA
I3U39_05215	COG0066	3-isopropylmalate dehydratase activity
I3U39_05220	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I3U39_05230	COG2079	MmgE PrpD family protein
I3U39_05235	COG2188	Transcriptional regulator
I3U39_05265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3U39_05275	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I3U39_05285	COG0667	Aldo Keto reductase
I3U39_05295	COG1595	DNA-templated transcription, initiation
I3U39_05300	COG2814	Major facilitator Superfamily
I3U39_05355	COG1278	Cold shock
I3U39_05395	COG2814	Major facilitator Superfamily
I3U39_05455	COG1764	response to oxidative stress
I3U39_05460	COG1846	Transcriptional regulator
I3U39_05465	COG1216	Glycosyl transferase, family 2
I3U39_05470	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3U39_05470	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3U39_05500	COG0259	pyridoxamine-phosphate oxidase activity
I3U39_05510	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_05515	COG5651	PPE family
I3U39_05545	COG4977	sequence-specific DNA binding
I3U39_05570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_05580	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3U39_05600	COG2186	Transcriptional regulator
I3U39_05605	COG0545	Peptidyl-prolyl cis-trans isomerase
I3U39_05645	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3U39_05650	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I3U39_05695	COG1012	belongs to the aldehyde dehydrogenase family
I3U39_05710	COG3022	response to hydroperoxide
I3U39_05720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3U39_05755	COG1309	transcriptional regulator
I3U39_05845	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I3U39_05870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_05880	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I3U39_05900	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_05940	COG1393	Belongs to the ArsC family
I3U39_05945	COG0583	DNA-binding transcription factor activity
I3U39_05985	COG0183	Belongs to the thiolase family
I3U39_06040	COG0438	transferase activity, transferring glycosyl groups
I3U39_06045	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3U39_06090	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I3U39_06095	COG1846	Transcriptional regulator
I3U39_06145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3U39_06155	COG2326	polyphosphate kinase activity
I3U39_06170	COG2084	Dehydrogenase
I3U39_06185	COG0523	cobalamin synthesis protein
I3U39_06190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3U39_06195	COG0235	Class ii aldolase
I3U39_06200	COG1396	sequence-specific DNA binding
I3U39_06205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3U39_06210	COG0166	Belongs to the GPI family
I3U39_06320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U39_06350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3U39_06355	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3U39_06355	COG0315	cyclic pyranopterin monophosphate synthase activity
I3U39_06395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3U39_06400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3U39_06490	COG2235	arginine
I3U39_06505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3U39_06520	COG1252	NADH dehydrogenase
I3U39_06530	COG0084	hydrolase, TatD family'
I3U39_06535	COG3583	domain protein
I3U39_06550	COG2815	serine threonine protein kinase
I3U39_06550	COG0515	serine threonine protein kinase
I3U39_06570	COG0456	acetyltransferase
I3U39_06570	COG1846	Transcriptional regulator
I3U39_06575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I3U39_06580	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_06620	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I3U39_06630	COG1309	transcriptional regulator
I3U39_06670	COG1309	transcriptional regulator
I3U39_06715	COG3956	TIGRFAM MazG family protein
I3U39_06730	COG2837	iron assimilation
I3U39_06735	COG2822	iron ion transport
I3U39_06770	COG0596	Alpha beta hydrolase
I3U39_06795	COG0427	acetyl-CoA hydrolase
I3U39_06845	COG1846	Transcriptional regulator
I3U39_06860	COG1024	Enoyl-CoA hydratase
I3U39_06885	COG0183	Belongs to the thiolase family
I3U39_06890	COG2755	lipolytic protein G-D-S-L family
I3U39_06895	COG0657	acetylesterase activity
I3U39_06905	COG1714	RDD family
I3U39_06920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3U39_06940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3U39_06950	COG1331	Highly conserved protein containing a thioredoxin domain
I3U39_06955	COG3631	Ketosteroid isomerase-related protein
I3U39_06970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3U39_06975	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_06980	COG2124	cytochrome p450
I3U39_07000	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_07040	COG2272	Belongs to the type-B carboxylesterase lipase family
I3U39_07050	COG1174	glycine betaine transport
I3U39_07060	COG1174	glycine betaine transport
I3U39_07105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3U39_07115	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I3U39_07120	COG0726	polysaccharide deacetylase
I3U39_07190	COG1570	exodeoxyribonuclease VII activity
I3U39_07200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I3U39_07215	COG1966	Carbon starvation protein
I3U39_07240	COG3189	MarR family transcriptional regulator
I3U39_07245	COG0012	GTP binding
I3U39_07270	COG2132	Multicopper oxidase
I3U39_07280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3U39_07290	COG0488	(ABC) transporter
I3U39_07345	COG2409	Drug exporters of the RND superfamily
I3U39_07380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3U39_07400	COG1716	ATPase activity
I3U39_07430	COG1051	belongs to the nudix hydrolase family
I3U39_07455	COG1217	gtp-binding protein TYPA
I3U39_07465	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I3U39_07470	COG1609	Transcriptional regulator
I3U39_07470	COG2207	Transcriptional regulator
I3U39_07530	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3U39_07530	COG1902	pentaerythritol trinitrate reductase activity
I3U39_07540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I3U39_07550	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3U39_07555	COG1012	belongs to the aldehyde dehydrogenase family
I3U39_07560	COG0506	proline dehydrogenase activity
I3U39_07565	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_07590	COG2207	Transcriptional regulator
I3U39_07605	COG1611	Belongs to the LOG family
I3U39_07610	COG1611	Belongs to the LOG family
I3U39_07615	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_07625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3U39_07630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3U39_07635	COG0463	Glycosyl transferase, family 2
I3U39_07650	COG0519	Catalyzes the synthesis of GMP from XMP
I3U39_07660	COG0297	glycogen (starch) synthase activity
I3U39_07685	COG3559	Exporter of polyketide antibiotics
I3U39_07690	COG1131	(ABC) transporter
I3U39_07695	COG1309	transcriptional regulator
I3U39_07705	COG1595	DNA-templated transcription, initiation
I3U39_07710	COG5662	AntiSigma factor
I3U39_07715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3U39_07785	COG0598	Magnesium transport protein CorA
I3U39_07790	COG2095	MarC family integral membrane protein
I3U39_07805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U39_07810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U39_07830	COG3835	regulator
I3U39_07835	COG1073	alpha beta
I3U39_07840	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3U39_07840	COG0567	Dehydrogenase, E1 component
I3U39_07850	COG2814	Major facilitator Superfamily
I3U39_07910	COG0277	FAD linked oxidase domain protein
I3U39_07915	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_07930	COG0668	transmembrane transport
I3U39_08020	COG2814	Major facilitator Superfamily
I3U39_08050	COG0019	diaminopimelate decarboxylase activity
I3U39_08055	COG0460	homoserine dehydrogenase
I3U39_08060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3U39_08095	COG2890	protein-(glutamine-N5) methyltransferase activity
I3U39_08105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3U39_08115	COG0356	it plays a direct role in the translocation of protons across the membrane
I3U39_08120	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3U39_08145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I3U39_08205	COG0346	lactoylglutathione lyase activity
I3U39_08210	COG0183	Belongs to the thiolase family
I3U39_08215	COG2409	Drug exporters of the RND superfamily
I3U39_08230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I3U39_08235	COG0366	Alpha amylase catalytic
I3U39_08240	COG0058	SHG alpha-glucan phosphorylase activity
I3U39_08255	COG1335	isochorismatase
I3U39_08265	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I3U39_08280	COG3191	aminopeptidase activity
I3U39_08325	COG0604	alcohol dehydrogenase
I3U39_08345	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_08360	COG0419	ATPase involved in DNA repair
I3U39_08365	COG1024	Enoyl-CoA hydratase
I3U39_08375	COG0243	molybdopterin cofactor binding
I3U39_08390	COG2188	Transcriptional regulator
I3U39_08445	COG0596	Alpha beta hydrolase
I3U39_08450	COG3757	hydrolase, family 25
I3U39_08465	COG1051	belongs to the nudix hydrolase family
I3U39_08485	COG1309	transcriptional regulator
I3U39_08500	COG4585	Histidine kinase
I3U39_08505	COG2197	response regulator
I3U39_08515	COG2239	Acts as a magnesium transporter
I3U39_08525	COG0300	oxidoreductase activity
I3U39_08535	COG0656	L-ascorbic acid biosynthetic process
I3U39_08550	COG1376	ErfK ybiS ycfS ynhG family protein
I3U39_08565	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I3U39_08570	COG0433	COG0433 Predicted ATPase
I3U39_08585	COG0300	oxidoreductase activity
I3U39_08600	COG1301	dicarboxylic acid transport
I3U39_08610	COG0531	amino acid
I3U39_08630	COG4424	Sulfotransferase
I3U39_08635	COG3119	arylsulfatase activity
I3U39_08670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3U39_08670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3U39_08755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3U39_08850	COG2902	Dehydrogenase
I3U39_08855	COG0824	Thioesterase
I3U39_08870	COG0366	Alpha amylase catalytic
I3U39_08905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I3U39_08925	COG1309	transcriptional regulator
I3U39_08940	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I3U39_08960	COG0740	serine-type endopeptidase activity
I3U39_08965	COG0740	serine-type endopeptidase activity
I3U39_09015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I3U39_09025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3U39_09025	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3U39_09030	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3U39_09040	COG1388	LysM domain
I3U39_09070	COG0525	valine-tRNA ligase activity
I3U39_09075	COG0285	dihydrofolate synthase activity
I3U39_09090	COG1530	ribonuclease E activity
I3U39_09090	COG1530	ribonuclease E activity
I3U39_09120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I3U39_09140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3U39_09145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I3U39_09150	COG0542	response to heat
I3U39_09160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I3U39_09170	COG0406	alpha-ribazole phosphatase activity
I3U39_09175	COG2755	lipolytic protein G-D-S-L family
I3U39_09195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U39_09230	COG2308	Evidence 4 Homologs of previously reported genes of
I3U39_09240	COG1305	Transglutaminase-like
I3U39_09270	COG3387	PFAM Glycoside hydrolase 15-related
I3U39_09285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U39_09320	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I3U39_09325	COG4208	sulfate ABC transporter
I3U39_09385	COG0484	heat shock protein binding
I3U39_09435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3U39_09465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3U39_09480	COG0076	glutamate decarboxylase activity
I3U39_09515	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_09565	COG0423	glycine-tRNA ligase activity
I3U39_09570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3U39_09575	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I3U39_09595	COG0358	DNA primase activity
I3U39_09665	COG0745	RESPONSE REGULATOR receiver
I3U39_09670	COG5002	protein histidine kinase activity
I3U39_09720	COG2199	diguanylate cyclase activity
I3U39_09760	COG0488	(ABC) transporter
I3U39_09785	COG1960	acyl-CoA dehydrogenase activity
I3U39_09790	COG1335	isochorismatase
I3U39_09800	COG0058	SHG alpha-glucan phosphorylase activity
I3U39_09840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U39_09845	COG1960	acyl-CoA dehydrogenase activity
I3U39_09850	COG0183	Belongs to the thiolase family
I3U39_09870	COG1228	amidohydrolase
I3U39_09910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3U39_09940	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3U39_09965	COG0582	viral genome integration into host DNA
I3U39_10050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U39_10095	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I3U39_10100	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I3U39_10160	COG0714	Associated with various cellular activities
I3U39_10185	COG0557	exoribonuclease II activity
I3U39_10195	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_10220	COG0174	glutamine synthetase
I3U39_10225	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I3U39_10255	COG2205	protein histidine kinase activity
I3U39_10285	COG0174	glutamine synthetase
I3U39_10295	COG0477	Major facilitator Superfamily
I3U39_10305	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I3U39_10325	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I3U39_10330	COG0321	lipoyl(octanoyl) transferase activity
I3U39_10345	COG1872	DUF167
I3U39_10365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3U39_10375	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I3U39_10380	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3U39_10410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3U39_10455	COG2010	Cytochrome c
I3U39_10460	COG1845	cytochrome c oxidase, subunit III
I3U39_10465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3U39_10500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3U39_10525	COG0003	Pfam Anion-transporting ATPase
I3U39_10535	COG0204	Acyl-transferase
I3U39_10540	COG5650	phosphatidylinositol metabolic process
I3U39_10550	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I3U39_10575	COG0142	geranyltranstransferase activity
I3U39_10615	COG0768	penicillin binding
I3U39_10635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I3U39_10645	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3U39_10660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I3U39_10685	COG0640	Transcriptional regulator
I3U39_10740	COG0154	amidase activity
I3U39_10750	COG2957	Belongs to the agmatine deiminase family
I3U39_10760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3U39_10770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3U39_10780	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_10810	COG2814	Major facilitator Superfamily
I3U39_10885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_10890	COG2030	dehydratase
I3U39_10910	COG1024	Enoyl-CoA hydratase
I3U39_10925	COG1309	transcriptional regulator
I3U39_10945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U39_10990	COG2072	flavoprotein involved in K transport
I3U39_11005	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_11010	COG1960	acyl-CoA dehydrogenase activity
I3U39_11030	COG1960	acyl-CoA dehydrogenase activity
I3U39_11055	COG3621	Patatin-like phospholipase
I3U39_11125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3U39_11155	COG1968	undecaprenyl-diphosphatase activity
I3U39_11190	COG1218	3'(2'),5'-bisphosphate nucleotidase
I3U39_11200	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_11225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U39_11235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U39_11235	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I3U39_11250	COG2860	membrane
I3U39_11260	COG1410	methionine synthase
I3U39_11260	COG0646	methionine synthase
I3U39_11265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3U39_11275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I3U39_11310	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I3U39_11315	COG1034	ATP synthesis coupled electron transport
I3U39_11320	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3U39_11325	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3U39_11405	COG0513	Belongs to the DEAD box helicase family
I3U39_11440	COG0028	Belongs to the TPP enzyme family
I3U39_11455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3U39_11460	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I3U39_11465	COG4122	O-methyltransferase activity
I3U39_11495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3U39_11500	COG4521	taurine ABC transporter
I3U39_11505	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I3U39_11540	COG2378	regulation of single-species biofilm formation
I3U39_11545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3U39_11580	COG0300	oxidoreductase activity
I3U39_11635	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I3U39_11645	COG0463	Glycosyl transferase, family 2
I3U39_11650	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_11680	COG0604	alcohol dehydrogenase
I3U39_11680	COG3321	synthase
I3U39_11680	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_11700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3U39_11710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I3U39_11715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_11735	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I3U39_11745	COG1404	Belongs to the peptidase S8 family
I3U39_11760	COG4842	Belongs to the WXG100 family
I3U39_11790	COG0464	growth
I3U39_11810	COG0583	DNA-binding transcription factor activity
I3U39_11840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3U39_11845	COG1169	isochorismate synthase
I3U39_11850	COG0789	Transcriptional regulator
I3U39_11855	COG1021	2,3-dihydroxybenzoate-AMP ligase
I3U39_11885	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I3U39_11910	COG3321	synthase
I3U39_11910	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_11910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U39_11910	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_11910	COG0300	oxidoreductase activity
I3U39_11925	COG1132	(ABC) transporter
I3U39_11930	COG2375	cellular response to nickel ion
I3U39_11930	COG1132	(ABC) transporter
I3U39_11935	COG0477	Major facilitator Superfamily
I3U39_11940	COG5285	phytanoyl-CoA dioxygenase
I3U39_11950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3U39_11955	COG0456	acetyltransferase
I3U39_11970	COG2837	iron assimilation
I3U39_11980	COG2186	Transcriptional regulator
I3U39_11985	COG2807	transmembrane transport
I3U39_11995	COG2409	Drug exporters of the RND superfamily
I3U39_12005	COG0789	Transcriptional regulator
I3U39_12050	COG1012	belongs to the aldehyde dehydrogenase family
I3U39_12090	COG0475	glutathione-regulated potassium exporter activity
I3U39_12160	COG0237	dephospho-CoA kinase activity
I3U39_12160	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I3U39_12295	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_12345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I3U39_12350	COG0072	phenylalanine-tRNA ligase activity
I3U39_12350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3U39_12360	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3U39_12365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I3U39_12370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3U39_12375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I3U39_12380	COG1438	arginine binding
I3U39_12385	COG0137	argininosuccinate synthase activity
I3U39_12425	COG2835	tetraacyldisaccharide 4'-kinase activity
I3U39_12430	COG1309	transcriptional regulator
I3U39_12435	COG2094	Belongs to the DNA glycosylase MPG family
I3U39_12450	COG0488	(ABC) transporter
I3U39_12460	COG0647	UMP catabolic process
I3U39_12475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I3U39_12495	COG0504	CTP synthase activity
I3U39_12500	COG0494	nUDIX hydrolase
I3U39_12520	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I3U39_12535	COG1160	GTP binding
I3U39_12545	COG1403	HNH endonuclease
I3U39_12625	COG1053	succinate dehydrogenase
I3U39_12625	COG3976	FMN-binding domain protein
I3U39_12655	COG1960	acyl-CoA dehydrogenase activity
I3U39_12715	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3U39_12715	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3U39_12730	COG1253	flavin adenine dinucleotide binding
I3U39_12735	COG1253	flavin adenine dinucleotide binding
I3U39_12745	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3U39_12800	COG0832	Belongs to the urease beta subunit family
I3U39_12810	COG0830	nickel cation binding
I3U39_12825	COG1252	NADH dehydrogenase
I3U39_12835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_12870	COG0243	molybdopterin cofactor binding
I3U39_12880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3U39_12895	COG1546	Belongs to the CinA family
I3U39_12895	COG1058	Belongs to the CinA family
I3U39_12905	COG4977	sequence-specific DNA binding
I3U39_12910	COG1741	Belongs to the pirin family
I3U39_12930	COG1968	undecaprenyl-diphosphatase activity
I3U39_12935	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I3U39_12960	COG0277	FAD linked oxidase domain protein
I3U39_12970	COG1309	transcriptional regulator
I3U39_12985	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I3U39_12990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I3U39_12995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3U39_13020	COG4290	ribonuclease
I3U39_13050	COG0791	NLP P60 protein
I3U39_13050	COG3883	PFAM NLP P60 protein
I3U39_13065	COG3415	Transposase
I3U39_13065	COG2801	Transposase and inactivated derivatives
I3U39_13090	COG0477	Major facilitator Superfamily
I3U39_13110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I3U39_13115	COG0067	glutamate synthase
I3U39_13115	COG0070	glutamate synthase
I3U39_13115	COG0069	glutamate synthase activity
I3U39_13140	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I3U39_13155	COG1960	acyl-CoA dehydrogenase activity
I3U39_13170	COG0443	Heat shock 70 kDa protein
I3U39_13175	COG0596	Alpha beta hydrolase
I3U39_13180	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_13205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3U39_13215	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I3U39_13240	COG2890	protein-(glutamine-N5) methyltransferase activity
I3U39_13310	COG1982	Orn Lys Arg decarboxylase major
I3U39_13370	COG0028	Belongs to the TPP enzyme family
I3U39_13380	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_13400	COG1309	transcriptional regulator
I3U39_13405	COG2957	Belongs to the agmatine deiminase family
I3U39_13410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U39_13425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3U39_13475	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I3U39_13490	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I3U39_13510	COG0640	Transcriptional regulator
I3U39_13520	COG0798	PFAM Bile acid sodium symporter
I3U39_13525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3U39_13530	COG0390	transport system, permease component
I3U39_13550	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_13645	COG0745	RESPONSE REGULATOR receiver
I3U39_13650	COG2205	protein histidine kinase activity
I3U39_13665	COG0745	RESPONSE REGULATOR receiver
I3U39_13670	COG2205	protein histidine kinase activity
I3U39_13685	COG1917	Cupin 2, conserved barrel domain protein
I3U39_13690	COG3707	response regulator
I3U39_13730	COG3467	pyridoxamine 5'-phosphate
I3U39_13755	COG0640	Transcriptional regulator
I3U39_13775	COG1309	transcriptional regulator
I3U39_13780	COG2072	flavoprotein involved in K transport
I3U39_13790	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_13795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I3U39_13800	COG0561	phosphatase activity
I3U39_13805	COG0673	inositol 2-dehydrogenase activity
I3U39_13810	COG0738	Major facilitator superfamily
I3U39_13895	COG1271	oxidase subunit
I3U39_13900	COG1294	oxidase, subunit
I3U39_13905	COG4988	ABC transporter
I3U39_13910	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I3U39_13935	COG1946	Acyl-CoA thioesterase
I3U39_13980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3U39_13985	COG1846	Transcriptional regulator
I3U39_14020	COG0483	inositol monophosphate 1-phosphatase activity
I3U39_14030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I3U39_14035	COG0131	Imidazoleglycerol-phosphate dehydratase
I3U39_14040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3U39_14065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I3U39_14080	COG1309	transcriptional regulator
I3U39_14095	COG0583	DNA-binding transcription factor activity
I3U39_14100	COG0579	oxidoreductase
I3U39_14140	COG2755	lipolytic protein G-D-S-L family
I3U39_14140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3U39_14195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I3U39_14215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I3U39_14220	COG2814	Major facilitator Superfamily
I3U39_14225	COG0583	DNA-binding transcription factor activity
I3U39_14275	COG2239	Acts as a magnesium transporter
I3U39_14305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3U39_14315	COG2304	oxidoreductase activity
I3U39_14325	COG0714	Associated with various cellular activities
I3U39_14335	COG0791	NLP P60 protein
I3U39_14335	COG3883	PFAM NLP P60 protein
I3U39_14345	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3U39_14350	COG1309	transcriptional regulator
I3U39_14375	COG0488	(ABC) transporter
I3U39_14390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3U39_14405	COG0456	acetyltransferase
I3U39_14415	COG2151	metal-sulfur cluster biosynthetic enzyme
I3U39_14430	COG0396	ATPase activity
I3U39_14455	COG1131	(ABC) transporter
I3U39_14495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3U39_14570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3U39_14630	COG0531	amino acid
I3U39_14685	COG2011	ABC-type metal ion transport system permease component
I3U39_14690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3U39_14710	COG0477	Major facilitator Superfamily
I3U39_14745	COG0657	acetylesterase activity
I3U39_14750	COG1953	Uracil, thiamine, allantoin
I3U39_14760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3U39_14765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U39_14775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I3U39_14785	COG1758	RNA polymerase activity
I3U39_14805	COG0284	orotidine-5'-phosphate decarboxylase activity
I3U39_14810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3U39_14815	COG0505	Belongs to the CarA family
I3U39_14835	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I3U39_14855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I3U39_14865	COG0006	proline dipeptidase activity
I3U39_14880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I3U39_14885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I3U39_14900	COG4106	trans-aconitate 2-methyltransferase activity
I3U39_14915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3U39_14930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I3U39_14980	COG0701	Predicted permease
I3U39_15005	COG2272	Belongs to the type-B carboxylesterase lipase family
I3U39_15045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3U39_15055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3U39_15065	COG0747	negative chemotaxis
I3U39_15070	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3U39_15085	COG2255	four-way junction helicase activity
I3U39_15095	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I3U39_15130	COG1946	Acyl-CoA thioesterase
I3U39_15135	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I3U39_15145	COG0438	transferase activity, transferring glycosyl groups
I3U39_15185	COG4762	Protein conserved in bacteria
I3U39_15240	COG1309	transcriptional regulator
I3U39_15265	COG3878	Protein conserved in bacteria
I3U39_15305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U39_15320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3U39_15320	COG2080	2 iron, 2 sulfur cluster binding
I3U39_15335	COG0402	S-adenosylhomocysteine deaminase activity
I3U39_15355	COG2233	PERMEase
I3U39_15375	COG1953	Uracil, thiamine, allantoin
I3U39_15385	COG1301	dicarboxylic acid transport
I3U39_15395	COG4266	Belongs to the allantoicase family
I3U39_15420	COG0501	Belongs to the peptidase M48B family
I3U39_15435	COG0477	Major facilitator Superfamily
I3U39_15490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U39_15500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3U39_15540	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3U39_15845	COG3883	PFAM NLP P60 protein
I3U39_15845	COG0791	NLP P60 protein
I3U39_15860	COG4974	Belongs to the 'phage' integrase family
I3U39_15875	COG3253	May function as heme-dependent peroxidase
I3U39_15880	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3U39_15885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I3U39_15895	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I3U39_15910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3U39_15915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3U39_15920	COG0531	amino acid
I3U39_15925	COG0569	domain protein
I3U39_15955	COG0702	epimerase
I3U39_15970	COG0756	dUTP diphosphatase activity
I3U39_16015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3U39_16065	COG3220	belongs to the UPF0276 family
I3U39_16135	COG2801	Transposase and inactivated derivatives
I3U39_16135	COG3415	Transposase
I3U39_16145	COG1388	LysM domain
I3U39_16160	COG1960	acyl-CoA dehydrogenase activity
I3U39_16170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3U39_16190	COG1196	nuclear chromosome segregation
I3U39_16210	COG1126	abc transporter atp-binding protein
I3U39_16215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3U39_16220	COG0765	amino acid transport
I3U39_16225	COG0765	amino acid transport
I3U39_16275	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
I3U39_16280	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
I3U39_16295	COG1842	Phage shock protein A
I3U39_16300	COG1396	sequence-specific DNA binding
I3U39_16310	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_16320	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3U39_16375	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I3U39_16380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3U39_16395	COG3214	Protein conserved in bacteria
I3U39_16435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I3U39_16445	COG0659	secondary active sulfate transmembrane transporter activity
I3U39_16455	COG0686	Belongs to the AlaDH PNT family
I3U39_16465	COG2072	flavoprotein involved in K transport
I3U39_16470	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_16540	COG2977	Belongs to the P-Pant transferase superfamily
I3U39_16545	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3U39_16565	COG1960	acyl-CoA dehydrogenase activity
I3U39_16570	COG1960	acyl-CoA dehydrogenase activity
I3U39_16575	COG1024	Enoyl-CoA hydratase
I3U39_16600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I3U39_16625	COG1017	nitric oxide dioxygenase activity
I3U39_16625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3U39_16630	COG1959	2 iron, 2 sulfur cluster binding
I3U39_16675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3U39_16675	COG1648	precorrin-2 dehydrogenase activity
I3U39_16700	COG0604	alcohol dehydrogenase
I3U39_16700	COG3321	synthase
I3U39_16700	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_16760	COG0579	oxidoreductase
I3U39_16780	COG1492	cobalamin metabolic process
I3U39_16790	COG1376	ErfK ybiS ycfS ynhG family protein
I3U39_16815	COG0750	zinc metalloprotease
I3U39_16840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I3U39_16905	COG0528	UMP kinase activity
I3U39_16910	COG3973	AAA domain
I3U39_16925	COG2723	6-phospho-beta-galactosidase activity
I3U39_16960	COG1309	transcriptional regulator
I3U39_17000	COG0583	DNA-binding transcription factor activity
I3U39_17025	COG0792	nuclease activity
I3U39_17085	COG0336	Belongs to the RNA methyltransferase TrmD family
I3U39_17125	COG1686	Belongs to the peptidase S11 family
I3U39_17145	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I3U39_17165	COG1304	FMN binding
I3U39_17190	COG1254	Belongs to the acylphosphatase family
I3U39_17215	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3U39_17220	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3U39_17240	COG0571	ribonuclease III activity
I3U39_17250	COG3599	regulation of cell shape
I3U39_17290	COG0742	ribosomal rna small subunit methyltransferase
I3U39_17295	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I3U39_17310	COG0657	acetylesterase activity
I3U39_17315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_17335	COG2124	cytochrome p450
I3U39_17350	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3U39_17355	COG1461	Dihydroxyacetone kinase
I3U39_17365	COG1024	Enoyl-CoA hydratase
I3U39_17390	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3U39_17395	COG0626	cystathionine gamma-synthase activity
I3U39_17400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3U39_17465	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3U39_17480	COG2271	Major facilitator Superfamily
I3U39_17515	COG0583	DNA-binding transcription factor activity
I3U39_17525	COG0778	Nitroreductase
I3U39_17540	COG0789	Transcriptional regulator
I3U39_17585	COG1309	transcriptional regulator
I3U39_17590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U39_17595	COG2124	cytochrome p450
I3U39_17625	COG0440	acetolactate synthase activity
I3U39_17640	COG1748	Saccharopine dehydrogenase
I3U39_17645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3U39_17665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U39_17685	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3U39_17695	COG2272	Belongs to the type-B carboxylesterase lipase family
I3U39_17710	COG0745	RESPONSE REGULATOR receiver
I3U39_17715	COG2205	protein histidine kinase activity
I3U39_17740	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3U39_17770	COG1024	Enoyl-CoA hydratase
I3U39_17775	COG0778	Nitroreductase
I3U39_17785	COG2252	PERMEase
I3U39_17825	COG2197	response regulator
I3U39_17830	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3U39_17840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3U39_17865	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3U39_17880	COG1309	transcriptional regulator
I3U39_17910	COG0110	maltose O-acetyltransferase activity
I3U39_17915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3U39_17940	COG1119	ATPase activity
I3U39_17950	COG2364	Membrane
I3U39_17955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3U39_17970	COG4607	ABC-type enterochelin transport system periplasmic component
I3U39_18020	COG1064	alcohol dehydrogenase
I3U39_18040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3U39_18045	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_18145	COG3878	Protein conserved in bacteria
I3U39_18200	COG0477	Major facilitator Superfamily
I3U39_18220	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_18250	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_18275	COG1335	isochorismatase
I3U39_18285	COG2855	membrane
I3U39_18295	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_18310	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_18315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3U39_18490	COG1690	Belongs to the RtcB family
I3U39_18715	COG2205	protein histidine kinase activity
I3U39_18720	COG0745	RESPONSE REGULATOR receiver
I3U39_18760	COG0739	heme binding
I3U39_18830	COG2272	Belongs to the type-B carboxylesterase lipase family
I3U39_18845	COG0183	Belongs to the thiolase family
I3U39_18880	COG1309	transcriptional regulator
I3U39_18910	COG0789	Transcriptional regulator
I3U39_18920	COG0028	Belongs to the TPP enzyme family
I3U39_19255	COG0582	viral genome integration into host DNA
I3U39_19275	COG2177	Part of the ABC transporter FtsEX involved in
I3U39_19280	COG2884	Cell division ATP-binding protein ftsE
I3U39_19290	COG0668	transmembrane transport
I3U39_19330	COG0483	inositol monophosphate 1-phosphatase activity
I3U39_19335	COG1960	acyl-CoA dehydrogenase activity
I3U39_19340	COG1960	acyl-CoA dehydrogenase activity
I3U39_19355	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_19365	COG0542	response to heat
I3U39_19410	COG3480	Lon protease (S16) C-terminal proteolytic domain
I3U39_19415	COG3011	Protein conserved in bacteria
I3U39_19430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U39_19435	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U39_19450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U39_19485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3U39_19485	COG0475	glutathione-regulated potassium exporter activity
I3U39_19500	COG0596	Alpha beta hydrolase
I3U39_19515	COG0745	RESPONSE REGULATOR receiver
I3U39_19525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3U39_19525	COG2146	nitrite reductase [NAD(P)H] activity
I3U39_19530	COG2223	nitrite transmembrane transporter activity
I3U39_19570	COG0513	Belongs to the DEAD box helicase family
I3U39_19585	COG0406	alpha-ribazole phosphatase activity
I3U39_19605	COG1597	lipid kinase activity
I3U39_19620	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I3U39_19630	COG1595	DNA-templated transcription, initiation
I3U39_19635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3U39_19640	COG2135	peptidase activity
I3U39_19645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I3U39_19650	COG1162	GTPase activity
I3U39_19685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I3U39_19780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3U39_19785	COG0604	alcohol dehydrogenase
I3U39_19785	COG3321	synthase
I3U39_19790	COG3321	synthase
I3U39_19790	COG0604	alcohol dehydrogenase
I3U39_19795	COG1960	acyl-CoA dehydrogenase activity
I3U39_19805	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_19810	COG0653	protein targeting
I3U39_19820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3U39_19825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3U39_19835	COG1309	transcriptional regulator
I3U39_19850	COG5401	PFAM Sporulation and spore germination
I3U39_19855	COG5002	protein histidine kinase activity
I3U39_19865	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_19870	COG1285	pathogenesis
I3U39_19900	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3U39_19905	COG0531	amino acid
I3U39_19915	COG1482	cell wall glycoprotein biosynthetic process
I3U39_19945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3U39_19950	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I3U39_19950	COG0778	Nitroreductase
I3U39_19965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3U39_19980	COG1316	TRANSCRIPTIONal
I3U39_20000	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I3U39_20010	COG2175	clavaminate synthase activity
I3U39_20035	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I3U39_20035	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I3U39_20045	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_20060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U39_20080	COG3265	gluconokinase activity
I3U39_20085	COG1960	acyl-CoA dehydrogenase activity
I3U39_20100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_20120	COG4770	biotin carboxylase activity
I3U39_20130	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I3U39_20150	COG1012	belongs to the aldehyde dehydrogenase family
I3U39_20155	COG1309	transcriptional regulator
I3U39_20160	COG1201	RNA secondary structure unwinding
I3U39_20195	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I3U39_20195	COG1473	amidohydrolase
I3U39_20210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3U39_20225	COG3883	PFAM NLP P60 protein
I3U39_20225	COG0791	NLP P60 protein
I3U39_20270	COG2009	succinate dehydrogenase
I3U39_20285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3U39_20290	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3U39_20295	COG1595	DNA-templated transcription, initiation
I3U39_20310	COG1686	Belongs to the peptidase S11 family
I3U39_20325	COG0708	Exodeoxyribonuclease III
I3U39_20385	COG1733	regulation of RNA biosynthetic process
I3U39_20390	COG2910	NAD(P)H-binding
I3U39_20395	COG1716	ATPase activity
I3U39_20395	COG0842	Transport permease protein
I3U39_20395	COG1131	(ABC) transporter
I3U39_20400	COG1357	PFAM Pentapeptide repeats (8 copies)
I3U39_20415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I3U39_20420	COG0587	DNA-directed DNA polymerase activity
I3U39_20425	COG1073	alpha beta
I3U39_20430	COG1309	transcriptional regulator
I3U39_20495	COG0519	Catalyzes the synthesis of GMP from XMP
I3U39_20495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I3U39_20505	COG0516	GMP reductase activity
I3U39_20565	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3U39_20580	COG0456	acetyltransferase
I3U39_20605	COG0076	glutamate decarboxylase activity
I3U39_20615	COG2267	carboxylic ester hydrolase activity
I3U39_20620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3U39_20645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_20655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3U39_20660	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I3U39_20695	COG1404	Belongs to the peptidase S8 family
I3U39_20725	COG2267	carboxylic ester hydrolase activity
I3U39_20780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I3U39_20785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U39_20795	COG2268	Band 7 protein
I3U39_20805	COG1088	dTDP-glucose 4,6-dehydratase activity
I3U39_20810	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I3U39_20855	COG0616	signal peptide processing
I3U39_20870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_20890	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I3U39_20900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I3U39_20910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3U39_20925	COG2272	Belongs to the type-B carboxylesterase lipase family
I3U39_20950	COG0477	Major facilitator Superfamily
I3U39_20965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I3U39_21005	COG0088	Forms part of the polypeptide exit tunnel
I3U39_21010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I3U39_21015	COG0051	transcription antitermination factor activity, RNA binding
I3U39_21050	COG0531	amino acid
I3U39_21080	COG0535	radical SAM domain protein
I3U39_21105	COG1834	amidinotransferase
I3U39_21110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3U39_21115	COG0531	amino acid
I3U39_21160	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I3U39_21165	COG1309	transcriptional regulator
I3U39_21190	COG1024	Enoyl-CoA hydratase
I3U39_21205	COG1960	acyl-CoA dehydrogenase activity
I3U39_21235	COG1113	amino acid transport
I3U39_21250	COG0085	RNA polymerase activity
I3U39_21255	COG0243	molybdopterin cofactor binding
I3U39_21310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3U39_21325	COG0277	FAD linked oxidase domain protein
I3U39_21345	COG4941	Belongs to the sigma-70 factor family
I3U39_21380	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3U39_21420	COG0783	Belongs to the Dps family
I3U39_21425	COG0693	protein deglycase activity
I3U39_21470	COG1404	Belongs to the peptidase S8 family
I3U39_21490	COG1280	lysine exporter protein (LysE YggA)
I3U39_21515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3U39_21560	COG0501	Belongs to the peptidase M48B family
I3U39_21565	COG0142	geranyltranstransferase activity
I3U39_21570	COG0644	oxidoreductase
I3U39_21580	COG0438	transferase activity, transferring glycosyl groups
I3U39_21600	COG4948	Mandelate Racemase Muconate Lactonizing
I3U39_21625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3U39_21630	COG0494	nUDIX hydrolase
I3U39_21640	COG4221	oxidoreductase activity
I3U39_21650	COG0300	oxidoreductase activity
I3U39_21660	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_21665	COG1012	belongs to the aldehyde dehydrogenase family
I3U39_21710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U39_21715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U39_21720	COG0183	Belongs to the thiolase family
I3U39_21790	COG3706	GGDEF domain
I3U39_21805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3U39_21815	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I3U39_21820	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_21825	COG4221	oxidoreductase activity
I3U39_21875	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I3U39_21880	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3U39_21920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U39_21950	COG3415	Transposase
I3U39_21950	COG2801	Transposase and inactivated derivatives
I3U39_21970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3U39_21975	COG1333	cytochrome c biogenesis protein
I3U39_21980	COG0785	Cytochrome C biogenesis protein
I3U39_21990	COG0406	alpha-ribazole phosphatase activity
I3U39_22010	COG3590	peptidase
I3U39_22055	COG1587	Uroporphyrinogen-III synthase
I3U39_22055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3U39_22080	COG2030	dehydratase
I3U39_22105	COG2070	2-Nitropropane dioxygenase
I3U39_22130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3U39_22135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U39_22235	COG1309	transcriptional regulator
I3U39_22245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U39_22295	COG2072	flavoprotein involved in K transport
I3U39_22310	COG2072	flavoprotein involved in K transport
I3U39_22315	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_22320	COG0657	acetylesterase activity
I3U39_22325	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U39_22335	COG0745	RESPONSE REGULATOR receiver
I3U39_22340	COG5002	protein histidine kinase activity
I3U39_22365	COG0300	oxidoreductase activity
I3U39_22420	COG2814	Major facilitator Superfamily
I3U39_22425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I3U39_22520	COG2733	membrane
I3U39_22530	COG2326	polyphosphate kinase activity
I3U39_22535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3U39_22570	COG2224	Isocitrate lyase
I3U39_22610	COG2226	methyltransferase
I3U39_22660	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I3U39_22695	COG0667	Aldo Keto reductase
I3U39_22720	COG4552	Acetyltransferase involved in intracellular survival and related
I3U39_22725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_22750	COG1505	serine-type exopeptidase activity
I3U39_22770	COG1073	alpha beta
I3U39_22775	COG2326	polyphosphate kinase activity
I3U39_22790	COG2223	nitrite transmembrane transporter activity
I3U39_22795	COG0640	Transcriptional regulator
I3U39_22825	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I3U39_22845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I3U39_22870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U39_22875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U39_22880	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_22890	COG1960	acyl-CoA dehydrogenase activity
I3U39_22895	COG1960	acyl-CoA dehydrogenase activity
I3U39_22900	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_22910	COG2070	2-Nitropropane dioxygenase
I3U39_22920	COG1024	Enoyl-CoA hydratase
I3U39_22925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3U39_22930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_22965	COG4638	Rieske (2fe-2S)
I3U39_23005	COG0175	sulfate reduction
I3U39_23075	COG2814	Major facilitator Superfamily
I3U39_23085	COG0351	phosphomethylpyrimidine kinase
I3U39_23095	COG1252	NADH dehydrogenase
I3U39_23105	COG1309	transcriptional regulator
I3U39_23115	COG1012	belongs to the aldehyde dehydrogenase family
I3U39_23150	COG0494	nUDIX hydrolase
I3U39_23160	COG2234	aminopeptidase activity
I3U39_23165	COG2234	aminopeptidase activity
I3U39_23175	COG1131	(ABC) transporter
I3U39_23180	COG2022	thiamine diphosphate biosynthetic process
I3U39_23215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3U39_23220	COG0515	serine threonine protein kinase
I3U39_23225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3U39_23255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3U39_23260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_23265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_23270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_23280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3U39_23285	COG1126	abc transporter atp-binding protein
I3U39_23325	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I3U39_23350	COG0415	Belongs to the DNA photolyase family
I3U39_23355	COG1090	epimerase
I3U39_23365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3U39_23380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3U39_23415	COG1994	Peptidase M50
I3U39_23435	COG0586	Pfam SNARE associated Golgi protein
I3U39_23465	COG4221	oxidoreductase activity
I3U39_23485	COG0542	response to heat
I3U39_23510	COG0789	Transcriptional regulator
I3U39_23515	COG0484	heat shock protein binding
I3U39_23520	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I3U39_23590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3U39_23590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3U39_23630	COG0247	lactate metabolic process
I3U39_23630	COG2181	nitrate reductase activity
I3U39_23640	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3U39_23680	COG3345	alpha-galactosidase
I3U39_23685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3U39_23690	COG1305	Transglutaminase-like
I3U39_23705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3U39_23730	COG1002	Type II restriction enzyme, methylase subunits
I3U39_23755	COG1012	belongs to the aldehyde dehydrogenase family
I3U39_23765	COG0454	-acetyltransferase
I3U39_23820	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_23825	COG1960	acyl-CoA dehydrogenase activity
I3U39_23840	COG3268	Saccharopine dehydrogenase
I3U39_23845	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_23850	COG3285	dna ligase
I3U39_23850	COG1793	dna ligase
I3U39_23860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3U39_23865	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_23915	COG2837	iron assimilation
I3U39_23940	COG1309	transcriptional regulator
I3U39_23945	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I3U39_23960	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I3U39_23965	COG1984	allophanate hydrolase subunit 2
I3U39_24030	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I3U39_24035	COG1802	Transcriptional regulator
I3U39_24065	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3U39_24075	COG0473	3-isopropylmalate dehydrogenase activity
I3U39_24090	COG1053	succinate dehydrogenase
I3U39_24110	COG0640	Transcriptional regulator
I3U39_24160	COG2318	DinB family
I3U39_24165	COG1960	acyl-CoA dehydrogenase activity
I3U39_24180	COG1660	Displays ATPase and GTPase activities
I3U39_24190	COG0183	Belongs to the thiolase family
I3U39_24495	COG0791	NLP P60 protein
I3U39_24495	COG3883	PFAM NLP P60 protein
I3U39_24515	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_24520	COG2030	dehydratase
I3U39_24535	COG0659	secondary active sulfate transmembrane transporter activity
I3U39_24540	COG1309	transcriptional regulator
I3U39_24545	COG0861	Integral membrane protein TerC family
I3U39_24570	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_24585	COG1472	Belongs to the glycosyl hydrolase 3 family
I3U39_24590	COG4941	Belongs to the sigma-70 factor family
I3U39_24595	COG3547	Transposase (IS116 IS110 IS902 family)
I3U39_24680	COG4981	capsule polysaccharide biosynthetic process
I3U39_24720	COG0438	transferase activity, transferring glycosyl groups
I3U39_24775	COG2197	response regulator
I3U39_24780	COG3850	Histidine kinase
I3U39_24800	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I3U39_24830	COG2409	Drug exporters of the RND superfamily
I3U39_24875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U39_24885	COG2197	response regulator
I3U39_24915	COG2353	YceI-like domain
I3U39_24930	COG2409	Drug exporters of the RND superfamily
I3U39_24945	COG4552	Acetyltransferase involved in intracellular survival and related
I3U39_24950	COG1832	CoA-binding protein
I3U39_24965	COG3590	peptidase
I3U39_24970	COG1376	ErfK ybiS ycfS ynhG family protein
I3U39_24975	COG1960	acyl-CoA dehydrogenase activity
I3U39_24985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U39_24995	COG1937	Protein conserved in bacteria
I3U39_25020	COG1012	belongs to the aldehyde dehydrogenase family
I3U39_25025	COG4122	O-methyltransferase activity
I3U39_25040	COG2267	carboxylic ester hydrolase activity
I3U39_25070	COG1704	LemA family
I3U39_25080	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_25135	COG1024	Enoyl-CoA hydratase
I3U39_25140	COG1802	Transcriptional regulator
I3U39_25150	COG2267	carboxylic ester hydrolase activity
I3U39_25155	COG1309	transcriptional regulator
I3U39_25185	COG0435	Glutathione S-transferase
I3U39_25225	COG1024	Enoyl-CoA hydratase
I3U39_25235	COG2211	Major facilitator Superfamily
I3U39_25240	COG2365	Tyrosine phosphatase family
I3U39_25305	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_25310	COG1012	belongs to the aldehyde dehydrogenase family
I3U39_25325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3U39_25330	COG1960	acyl-CoA dehydrogenase activity
I3U39_25335	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I3U39_25350	COG2226	methyltransferase
I3U39_25365	COG3800	Transcriptional regulator
I3U39_25365	COG1396	sequence-specific DNA binding
I3U39_25375	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I3U39_25415	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_25475	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I3U39_25485	COG0129	dihydroxy-acid dehydratase activity
I3U39_25505	COG2186	Transcriptional regulator
I3U39_25535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3U39_25540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U39_25550	COG0723	plastoquinol--plastocyanin reductase activity
I3U39_25570	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_25610	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_25625	COG0318	PFAM AMP-dependent synthetase and ligase
I3U39_25630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3U39_25635	COG1136	(ABC) transporter
I3U39_25645	COG1104	cysteine desulfurase activity
I3U39_25705	COG1309	transcriptional regulator
I3U39_25710	COG1819	glycosyl
I3U39_25755	COG1819	glycosyl
I3U39_25870	COG3263	regulation of cellular component size
I3U39_25950	COG1595	DNA-templated transcription, initiation
I3U39_25960	COG0783	Belongs to the Dps family
I3U39_26005	COG1252	NADH dehydrogenase
I3U39_26025	COG1937	Protein conserved in bacteria
I3U39_26050	COG1403	HNH endonuclease
I3U39_26220	COG2140	Oxalate decarboxylase
I3U39_26245	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3U39_26265	COG1376	ErfK ybiS ycfS ynhG family protein
I3U39_26285	COG2030	dehydratase
I3U39_26290	COG0488	(ABC) transporter
I3U39_26295	COG3757	hydrolase, family 25
I3U39_26360	COG0583	DNA-binding transcription factor activity
I3U39_26370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U39_26385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U39_26390	COG3757	hydrolase, family 25
I3U39_26470	COG0629	single-stranded DNA binding
I3U39_26485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3U39_26515	COG1260	myo-inositol-1-phosphate synthase
I3U39_26525	COG1113	amino acid transport
I3U39_26540	COG1309	transcriptional regulator
I3U39_26545	COG1028	Short-chain dehydrogenase reductase Sdr
I3U39_26560	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3U39_26565	COG0022	dehydrogenase e1 component
I3U39_26580	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I3U39_26585	COG2311	Membrane
I3U39_26650	COG0617	tRNA 3'-terminal CCA addition
I3U39_26670	COG1595	DNA-templated transcription, initiation
I3U39_26690	COG3409	Peptidoglycan-binding domain 1 protein
I3U39_26690	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3U39_26700	COG2124	cytochrome p450
I3U39_26710	COG1309	transcriptional regulator
I3U39_26730	COG1192	Involved in chromosome partitioning
I3U39_26735	COG0357	Ribosomal RNA small subunit methyltransferase G
I3U39_26745	COG0706	membrane insertase activity
I3U39_26750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane