locus-tag class description JDM601_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) JDM601_0003 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) JDM601_0004 ENOG4105K7N UPF0232 protein JDM601_0005 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) JDM601_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) JDM601_0021 ENOG4105TV9 FHA Domain-Containing protein JDM601_0028 ENOG4105MKU Transcriptional regulator JDM601_0029 ENOG4105H3G oxidoreductase JDM601_0033 ENOG4105E2A Dehydrogenase JDM601_0036 ENOG4105EUB pirin domain protein JDM601_0047 ENOG4106F1P AAA ATPase, central domain protein JDM601_0067 ENOG41062IE glyoxalase bleomycin resistance protein dioxygenase JDM601_0081 ENOG4107RFB Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) JDM601_0094 ENOG4108UGJ Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) JDM601_0095 ENOG4105C26 Dehydrogenase JDM601_0096 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr JDM601_0099 ENOG4108R86 Transcriptional regulator JDM601_0102 ENOG4105CQB FAD linked oxidase domain protein JDM601_0103 ENOG41060BG Tetr family transcriptional regulator JDM601_0108 ENOG4105C29 acyl-CoA thioesterase JDM601_0111 ENOG410719E cytochrome p450 JDM601_0112 ENOG4105E2A Dehydrogenase JDM601_0113 ENOG4105CNV Aldolase JDM601_0116 ENOG4105F95 Monooxygenase JDM601_0151 ENOG4105E5G Alpha beta hydrolase fold JDM601_0156 ENOG4105C01 Dihydroxy-acid dehydratase JDM601_0158 ENOG4105VPX protein, conserved in bacteria JDM601_0159 ENOG4108XIC integral membrane protein JDM601_0160 ENOG4105S7A ErfK ybiS ycfS ynhG family protein JDM601_0161 ENOG4105C9K Endothelin-converting enzyme 1 JDM601_0168 ENOG4108I9W Membrane JDM601_0171 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) JDM601_0174 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) JDM601_0180 ENOG4105GCF PGAM JDM601_0181 ENOG4105C1G acyl-Coa dehydrogenase JDM601_0183 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_0184 ENOG4105D2B acyl-CoA dehydrogenase JDM601_0188 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_0190 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase JDM601_0191 ENOG4105CSU acyl-Coa dehydrogenase JDM601_0195 ENOG4108M6P methyltransferase JDM601_0197 ENOG4105KIR Thiol-disulfide oxidoreductase dcc JDM601_0211 ENOG4105NTK Transcriptional repressor Mpra JDM601_0213 ENOG4105CS1 NAD(P)H quinone oxidoreductase JDM601_0215 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta JDM601_0218 ENOG41073B4 coagulation factor 5 8 type domain-containing protein JDM601_0220 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) JDM601_0225 ENOG4105CHR reductase JDM601_0226 ENOG4105CHU acetyl-coa acetyltransferase JDM601_0229 ENOG4105CSU acyl-Coa dehydrogenase JDM601_0233 ENOG4108FN7 Aldo keto reductase JDM601_0235 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) JDM601_0239 ENOG4107QZF nitrite reductase NADPH large subunit JDM601_0241 ENOG4105WZK nitrite reductase NADPH small subunit JDM601_0245 ENOG4107QND Nitrite extrusion protein JDM601_0248 ENOG4107R7A Allophanate hydrolase subunit 2 JDM601_0255 ENOG4105CHR reductase JDM601_0256 ENOG4105J5T Amp-dependent synthetase and ligase JDM601_0260 ENOG4105D2B acyl-CoA dehydrogenase JDM601_0261 ENOG4108JQ1 Dehydrogenase JDM601_0264 ENOG4107XDR Lactoylglutathione lyase JDM601_0266 ENOG4105EM7 Selenocysteine-specific translation elongation factor JDM601_0267 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) JDM601_0268 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) JDM601_0272 ENOG4105CQM Urea amidohydrolase subunit alpha JDM601_0273 ENOG4108YZ9 Urea amidohydrolase subunit gamma JDM601_0276 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein JDM601_0278 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) JDM601_0289 ENOG4105IIV Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) JDM601_0299 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin JDM601_0303 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase JDM601_0305 ENOG4105YVM Phosphoesterase, PA-phosphatase related JDM601_0322 ENOG4105DHP deoxycytidine triphosphate deaminase JDM601_0330 ENOG4105DF6 Fe-S oxidoreductase JDM601_0338 ENOG4105CFG Acts as a chaperone (By similarity) JDM601_0339 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ JDM601_0341 ENOG4105KNI merR family transcriptional Regulator JDM601_0346 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit JDM601_0361 ENOG4107XZ0 Peptidase M50 JDM601_0363 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis JDM601_0367 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR JDM601_0368 ENOG4105MGE Rhodanese domain protein JDM601_0370 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr JDM601_0371 ENOG4105CR4 methylisocitrate lyase JDM601_0382 ENOG4105CT1 (ABC) transporter JDM601_0388 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) JDM601_0390 ENOG4105IIU Aminopeptidase JDM601_0391 ENOG4108IG5 Transcriptional regulator JDM601_0392 ENOG4105F95 Monooxygenase JDM601_0394 ENOG4105DWF phosphomethylpyrimidine kinase JDM601_0396 ENOG4105C0R drug resistance transporter emrb qaca subfamily JDM601_0403 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) JDM601_0408 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) JDM601_0409 ENOG41076PI Short-chain dehydrogenase reductase Sdr JDM601_0411 ENOG4106A3M Cytochrome p-450 JDM601_0412 ENOG4105C26 Dehydrogenase JDM601_0415 ENOG41076PI Short-chain dehydrogenase reductase Sdr JDM601_0419 ENOG4105WWF Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) JDM601_0421 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme JDM601_0428 ENOG4105PDP Short chain dehydrogenase JDM601_0433 ENOG4107T8T UPF0173 metal-dependent hydrolase JDM601_0435 ENOG4105CPC Aldo Keto reductase JDM601_0440 ENOG4105C26 Dehydrogenase JDM601_0451 ENOG4108NUI synthase JDM601_0461 ENOG4106BRA Membrane JDM601_0463 ENOG4105V9F hemagglutinin JDM601_0466 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) JDM601_0475 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) JDM601_0476 ENOG4108YZJ Pfam:DUF2596 JDM601_0487 ENOG4105DNP FAD linked oxidase domain protein JDM601_0489 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) JDM601_0492 ENOG41063NU Membrane JDM601_0500 ENOG410900P UPF0336 protein JDM601_0501 ENOG4108RXW HAD-superfamily subfamily IB hydrolase JDM601_0509 ENOG4105DCG PHP domain protein JDM601_0523 ENOG4108RH7 phosphoglycerate mutase JDM601_0525 ENOG4107QIV Cytochrome c biogenesis protein JDM601_0527 ENOG4105CRE cytochrome C JDM601_0533 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) JDM601_0540 ENOG4105PDP Short chain dehydrogenase JDM601_0542 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_0545 ENOG4107TCW O-succinylbenzoate synthase JDM601_0552 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) JDM601_0557 ENOG4105CHH sulfate transporter JDM601_0560 ENOG4105CT3 Monooxygenase JDM601_0561 ENOG4108VPT UPF0234 protein JDM601_0564 ENOG41089UC methyltransferase, type 11 JDM601_0572 ENOG4105CHR reductase JDM601_0583 ENOG4107CD8 JDM601_0591 ENOG4107S1Q Phosphatase JDM601_0592 ENOG4105CNG UPF0061 protein JDM601_0597 ENOG4105C0D helicase JDM601_0600 ENOG4107QRT dEAD DEAH box helicase JDM601_0601 ENOG4105C4R Atp-dependent dna helicase JDM601_0605 ENOG4105C0H protease JDM601_0610 ENOG4107YU2 histidine triad (hIT) protein JDM601_0611 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) JDM601_0624 ENOG4105VT3 DNA binding domain protein, excisionase family JDM601_0631 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving JDM601_0632 ENOG4107S1Q Phosphatase JDM601_0639 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) JDM601_0644 ENOG4105DSY exodeoxyribonuclease V, gamma JDM601_0645 ENOG4105CPQ Dehydrogenase JDM601_0646 ENOG4105CTQ phosphohexokinase JDM601_0656 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) JDM601_0658 ENOG410900P UPF0336 protein JDM601_0659 ENOG4108F01 MaoC domain protein JDM601_0666 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase JDM601_0678 ENOG41082SK Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) JDM601_0682 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) JDM601_0687 ENOG4105CSU acyl-Coa dehydrogenase JDM601_0695 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) JDM601_0696 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) JDM601_0697 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) JDM601_0699 ENOG4108BAS reductase JDM601_0702 ENOG4105CHR reductase JDM601_0707 ENOG4107QX3 carboxylase JDM601_0709 ENOG4106YT9 Enoyl-CoA hydratase JDM601_0710 ENOG4105CY3 ABC transporter, permease JDM601_0712 ENOG4105D5P Methylmalonyl-coA mutase JDM601_0715 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F JDM601_0722 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_0725 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_0726 ENOG4105FDP GntR family transcriptional regulator JDM601_0729 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F JDM601_0730 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_0732 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_0733 ENOG4105D2B acyl-CoA dehydrogenase JDM601_0737 ENOG4105CGU Enoyl-CoA hydratase JDM601_0738 ENOG4105CHU acetyl-coa acetyltransferase JDM601_0739 ENOG4105C1G acyl-Coa dehydrogenase JDM601_0743 ENOG4108VGI doxx family JDM601_0745 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_0746 ENOG4105E39 Enoyl-CoA hydratase JDM601_0753 ENOG4108C33 Resolvase JDM601_0757 ENOG4105C0D helicase JDM601_0764 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) JDM601_0765 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) JDM601_0770 ENOG4105CMM transposase JDM601_0772 ENOG4105C0D helicase JDM601_0784 ENOG4105CHU acetyl-coa acetyltransferase JDM601_0785 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase JDM601_0787 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) JDM601_0789 ENOG4105CFI type iii restriction protein res subunit JDM601_0793 ENOG4105EPU Molybdenum cofactor synthesis domain protein JDM601_0797 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) JDM601_0798 ENOG4105VEQ Cold shock protein JDM601_0800 ENOG4105CHF Glutathione S-transferase JDM601_0807 ENOG4105FCS tRNA rRNA methyltransferase JDM601_0811 ENOG4105URP P-aminobenzoate N-oxygenase AurF JDM601_0814 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) JDM601_0817 ENOG41081K0 peptidylprolyl cis-trans isomerase JDM601_0824 ENOG4105BZ1 (ABC) transporter JDM601_0825 ENOG4105BZ1 (ABC) transporter JDM601_0828 ENOG4108VUG Enoyl-CoA hydratase JDM601_0830 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic JDM601_0833 ENOG4108M8W Monooxygenase JDM601_0840 ENOG4107YPT transcriptional regulator JDM601_0841 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) JDM601_0851 ENOG4105C1G acyl-Coa dehydrogenase JDM601_0852 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_0853 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_0857 ENOG41082SX arsR family transcriptional regulator JDM601_0858 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic JDM601_0866 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) JDM601_0867 ENOG41083YR Protein CrcB homolog JDM601_0868 ENOG4105KJJ Uncharacterized ACR, COG1993 JDM601_0870 ENOG4105C1G acyl-Coa dehydrogenase JDM601_0882 ENOG4106R7G Glycoside hydrolase family 5 JDM601_0884 ENOG4106R7G Glycoside hydrolase family 5 JDM601_0889 ENOG41082T9 Membrane JDM601_0892 ENOG4107QP8 phosphohexose isomerase JDM601_0896 ENOG4105DR5 peptidase JDM601_0897 ENOG4105CMV Succinyl-CoA synthetase subunit beta JDM601_0901 ENOG41078VV 34 kDa antigenic protein JDM601_0905 ENOG4105DC1 bifunctional purine biosynthesis protein purh JDM601_0909 ENOG4105EET magnesium chelatase JDM601_0910 ENOG4107KWJ von Willebrand factor, type A JDM601_0913 ENOG4105WH1 Two component transcriptional regulator luxr family JDM601_0914 ENOG4105D65 subunit l JDM601_0915 ENOG4105MKQ Monovalent cation H antiporter subunit C JDM601_0916 ENOG4108JPZ Monovalent cation H antiporter subunit D JDM601_0918 ENOG410684G monovalent cation H antiporter subunit F JDM601_0925 ENOG4105CGU Enoyl-CoA hydratase JDM601_0928 ENOG4107QX3 carboxylase JDM601_0929 ENOG4105C1G acyl-Coa dehydrogenase JDM601_0931 ENOG41067C8 50S ribosomal protein L32 JDM601_0932 ENOG4105ETX regulatoR JDM601_0933 ENOG41062D9 Histidine kinase JDM601_0935 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) JDM601_0937 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) JDM601_0940 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase JDM601_0941 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase JDM601_0953 ENOG4105D82 Glutamate dehydrogenase JDM601_0954 ENOG410870F Cyclic nucleotide-binding protein JDM601_0958 ENOG4105CRQ synthase (Component I) JDM601_0961 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase JDM601_0964 ENOG4105F8V Hydrolase, tatD family JDM601_0969 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) JDM601_0970 ENOG4107RCI amp-dependent synthetase and ligase JDM601_0971 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) JDM601_0972 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) JDM601_0982 ENOG4108IG5 Transcriptional regulator JDM601_0984 ENOG4105DXN mazG family JDM601_0988 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) JDM601_1006 ENOG41089UC methyltransferase, type 11 JDM601_1009 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_1017 ENOG4105E39 Enoyl-CoA hydratase JDM601_1020 ENOG4105CHU acetyl-coa acetyltransferase JDM601_1024 ENOG4105W8D rdd domain containing protein JDM601_1026 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) JDM601_1028 ENOG4105T1M mycothiol conjugate amidase mca JDM601_1030 ENOG4105C7Z Conserved Protein JDM601_1037 ENOG4105CS9 pantothenic acid kinase JDM601_1039 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) JDM601_1041 ENOG4108IAB Phoh family JDM601_1044 ENOG4107VMI polysaccharide deacetylase JDM601_1045 ENOG4105EUZ Beta-lactamase domain protein JDM601_1058 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) JDM601_1060 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) JDM601_1062 ENOG4105C3G gtp-binding protein JDM601_1076 ENOG4105D74 hydrolase JDM601_1078 ENOG4105CFF transcriptional regulator JDM601_1081 ENOG4105CR4 methylisocitrate lyase JDM601_1082 ENOG4105BZN citrate synthase JDM601_1086 ENOG4108UKI Enoyl-CoA hydratase JDM601_1092 ENOG4108RZE Tetr family transcriptional regulator JDM601_1106 ENOG4106A3M Cytochrome p-450 JDM601_1107 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr JDM601_1114 ENOG4106A3M Cytochrome p-450 JDM601_1115 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr JDM601_1117 ENOG4105CHU acetyl-coa acetyltransferase JDM601_1119 ENOG4108Z0R Transferase JDM601_1121 ENOG4105CGU Enoyl-CoA hydratase JDM601_1122 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F JDM601_1124 ENOG4105EA8 2-Nitropropane dioxygenase JDM601_1127 ENOG41086VY Fic/DOC family JDM601_1132 ENOG41088PD hydrolase JDM601_1140 ENOG410905P Pyridoxamine 5-phosphate JDM601_1146 ENOG410842T Pterin carbinolamine dehydratase JDM601_1147 ENOG4108U8T Mannosyltransferase JDM601_1150 ENOG4108IUE nitrate reductase beta subunit JDM601_1159 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) JDM601_1162 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase JDM601_1169 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) JDM601_1170 ENOG4105BZ9 Cytochrome C oxidase, subunit I JDM601_1172 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_1183 ENOG4105C3Q Glycosyl transferase, family 2 JDM601_1185 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) JDM601_1191 ENOG4105DIM ABC transporter JDM601_1192 ENOG4105CIG ABC transporter JDM601_1193 ENOG4108X07 Tetr family transcriptional regulator JDM601_1194 ENOG4107ZBN O-methyltransferase JDM601_1196 ENOG4106684 JDM601_1197 ENOG4105C0H protease JDM601_1202 ENOG4105CJW magnesium transporter JDM601_1211 ENOG4105D7N magnesium and cobalt transport protein CorA JDM601_1216 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 JDM601_1224 ENOG4105CQB FAD linked oxidase domain protein JDM601_1230 ENOG4105DEN Luciferase family JDM601_1233 ENOG4105C87 Aminotransferase class I and II JDM601_1237 ENOG4105BZ1 (ABC) transporter JDM601_1250 ENOG4107RCI amp-dependent synthetase and ligase JDM601_1252 ENOG4108IG5 Transcriptional regulator JDM601_1279 ENOG4105C11 sulfate adenylyltransferase), subunit 2 JDM601_1288 ENOG4105DYW oxidoreductase JDM601_1291 ENOG4105C75 arginyL-tRNA synthetase JDM601_1292 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) JDM601_1293 ENOG4105D6E homoserine dehydrogenase JDM601_1294 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) JDM601_1295 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) JDM601_1297 ENOG4105VFB Binds the 23S rRNA (By similarity) JDM601_1299 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) JDM601_1303 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) JDM601_1304 ENOG410679R F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) JDM601_1306 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) JDM601_1307 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) JDM601_1313 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) JDM601_1316 ENOG4105CMM transposase JDM601_1319 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) JDM601_1321 ENOG4105CSV Glutaminase JDM601_1323 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) JDM601_1326 ENOG4105CHU acetyl-coa acetyltransferase JDM601_1330 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) JDM601_1336 ENOG4107RKP Nicotinate phosphoribosyltransferase JDM601_1339 ENOG4105KXX peptidase s58 dmpa JDM601_1341 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) JDM601_1343 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) JDM601_1370 ENOG4105CMM transposase JDM601_1382 ENOG4108WKN secreted protein JDM601_1385 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) JDM601_1394 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) JDM601_1395 ENOG4105D7A ATP-binding protein JDM601_1396 ENOG4105EMU Dehydrogenase JDM601_1400 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_1403 ENOG4107QX3 carboxylase JDM601_1405 ENOG4105C1G acyl-Coa dehydrogenase JDM601_1406 ENOG4105DJG MaoC domain protein dehydratase JDM601_1408 ENOG4105CMJ mandelate racemase muconate lactonizing JDM601_1409 ENOG4108KF8 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) JDM601_1416 ENOG4105CEI nitrite reductase JDM601_1417 ENOG4105CSW GntR family transcriptional regulator JDM601_1420 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 JDM601_1424 ENOG4108RXW HAD-superfamily subfamily IB hydrolase JDM601_1427 ENOG4105CSH Transporter JDM601_1432 ENOG4105C7I Dehydrogenase JDM601_1434 ENOG4105CG3 alpha amylase, catalytic region JDM601_1439 ENOG4109057 JDM601_1442 ENOG4105MC2 DSBA oxidoreductase JDM601_1446 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation JDM601_1449 ENOG4107QK5 Homocysteine s-methyltransferase JDM601_1450 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) JDM601_1452 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein JDM601_1453 ENOG4105DQU oxidoreductase, subunit beta JDM601_1457 ENOG4105EG6 Saccharopine dehydrogenase JDM601_1460 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase JDM601_1463 ENOG4105C03 ribonuclease JDM601_1464 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) JDM601_1466 ENOG4105K46 50S ribosomal protein l27 JDM601_1467 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control JDM601_1473 ENOG4107RGD Major Facilitator superfamily JDM601_1478 ENOG4108RVA ribokinase JDM601_1480 ENOG4105D8X mechanosensitive ion channel JDM601_1481 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) JDM601_1487 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) JDM601_1488 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) JDM601_1490 ENOG4108TZC JDM601_1497 ENOG4105C1G acyl-Coa dehydrogenase JDM601_1498 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_1500 ENOG4105KQC Competence protein JDM601_1505 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) JDM601_1508 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) JDM601_1510 ENOG4105BZP glycoside hydrolase 15-related JDM601_1512 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein JDM601_1513 ENOG4108I5D sulfate abc transporter JDM601_1515 ENOG4108IJ6 ABC transporter JDM601_1526 ENOG4105XTG Pfam:DUF156 JDM601_1528 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase JDM601_1529 ENOG4105C0W non-ribosomal peptide synthetase JDM601_1542 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_1547 ENOG4105CMG Carbohydrate kinase JDM601_1549 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) JDM601_1550 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) JDM601_1552 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) JDM601_1555 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) JDM601_1563 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) JDM601_1565 ENOG4108XGZ Methyltransferase domain JDM601_1566 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) JDM601_1570 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) JDM601_1575 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) JDM601_1580 ENOG41064MX Tetr family transcriptional regulator JDM601_1590 ENOG4105DRS transport system, permease JDM601_1591 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component JDM601_1602 ENOG4108SVW integral membrane protein JDM601_1604 ENOG4108KPJ rna polymerase sigma factor JDM601_1609 ENOG4105F95 Monooxygenase JDM601_1616 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) JDM601_1621 ENOG4107GJV short-chain dehydrogenase reductase JDM601_1622 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_1624 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_1632 ENOG4105CFG Acts as a chaperone (By similarity) JDM601_1635 ENOG4105C5X domain protein JDM601_1647 ENOG4105H9W Short-chain dehydrogenase reductase Sdr JDM601_1650 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) JDM601_1651 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) JDM601_1652 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase JDM601_1666 ENOG4105CVJ phosphoglycerate mutase JDM601_1667 ENOG4108IMY Transcriptional regulator JDM601_1668 ENOG4105D7W serine acetyltransferase JDM601_1670 ENOG4105C3M thioredoxin reductase JDM601_1675 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) JDM601_1678 ENOG4105C5F glutamine synthetase JDM601_1682 ENOG4105C5F glutamine synthetase JDM601_1686 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) JDM601_1690 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) JDM601_1693 ENOG4105CM2 brancheD-chain amino acid aminotransferase JDM601_1695 ENOG41080Z7 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) JDM601_1696 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) JDM601_1710 ENOG4105CCU oxidase (Subunit III) JDM601_1716 ENOG4108IQE Amp-dependent synthetase and ligase JDM601_1719 ENOG4105D0U Arsenite-activated ATPase (ArsA) JDM601_1725 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase JDM601_1727 ENOG4105KYH transcriptional regulatory protein JDM601_1728 ENOG41090CE integral membrane protein JDM601_1731 ENOG4105R14 (LipO)protein JDM601_1737 ENOG4105CJN penicillin-binding protein JDM601_1741 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) JDM601_1743 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) JDM601_1744 ENOG4105DFU Cell wall formation (By similarity) JDM601_1754 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) JDM601_1756 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) JDM601_1759 ENOG4107R13 MMPL domain protein JDM601_1762 ENOG4105MSY salicylate hydroxylase JDM601_1767 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) JDM601_1768 ENOG4105CVJ phosphoglycerate mutase JDM601_1772 ENOG4105C8N cysteinyl-tRNA synthetase JDM601_1773 ENOG4108BAS reductase JDM601_1794 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) JDM601_1795 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) JDM601_1796 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) JDM601_1797 ENOG41063C6 UPF0235 protein JDM601_1799 ENOG4105RYD Toxic component of a toxin-antitoxin (TA) module. A JDM601_1800 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) JDM601_1804 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) JDM601_1805 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) JDM601_1813 ENOG4105C5X domain protein JDM601_1821 ENOG41084BS 50S ribosomal protein L35 JDM601_1822 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) JDM601_1827 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) JDM601_1828 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) JDM601_1831 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) JDM601_1833 ENOG4105C8Y Acetylornithine aminotransferase JDM601_1835 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) JDM601_1836 ENOG4105CDH Citrulline--aspartate ligase JDM601_1837 ENOG4105CH7 arginosuccinase JDM601_1840 ENOG4105C5H ABC transporter JDM601_1842 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) JDM601_1843 ENOG4105W49 UPF0434 protein JDM601_1845 ENOG4105CJ1 ABC, transporter JDM601_1846 ENOG4108VX5 3-methyladenine DNA glycosylase JDM601_1847 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) JDM601_1848 ENOG4105DSU hydrolase JDM601_1855 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) JDM601_1862 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) JDM601_1864 ENOG4105CAT Cytidine monophosphate kinase JDM601_1865 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) JDM601_1870 ENOG4105VTR Integrase JDM601_1874 ENOG4105KAV tspo and mbr like protein JDM601_1876 ENOG4107QUV Domain protein JDM601_1878 ENOG4107R1I NAD-dependent malic enzyme JDM601_1879 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) JDM601_1880 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) JDM601_1890 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) JDM601_1893 ENOG4105EC2 ftsk spoIIIe JDM601_1914 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein JDM601_1916 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving JDM601_1921 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) JDM601_1926 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor JDM601_1931 ENOG4107UAX integral membrane protein JDM601_1932 ENOG4105C37 (CBS) domain JDM601_1937 ENOG4105GCF PGAM JDM601_1938 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) JDM601_1943 ENOG4105CEP NADH dehydrogenase JDM601_1962 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) JDM601_1964 ENOG4105C5Q Transcriptional regulator JDM601_1970 ENOG4105MXB limonene-12-epoxide hydrolase JDM601_1978 ENOG4108J5G 6-phosphogluconate dehydrogenase JDM601_1981 ENOG4105C7R Atpase associated with various cellular activities aaa_3 JDM601_1988 ENOG4105CEV competence damage-inducible protein JDM601_1991 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) JDM601_1994 ENOG4107XFJ UPF0246 protein JDM601_1997 ENOG4107R72 Ceramidase JDM601_2000 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase JDM601_2009 ENOG4107RCI amp-dependent synthetase and ligase JDM601_2016 ENOG4105E39 Enoyl-CoA hydratase JDM601_2020 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) JDM601_2022 ENOG4108V1T peptidylprolyl cis-trans isomerase JDM601_2023 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein JDM601_2026 ENOG4108NUI synthase JDM601_2028 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase JDM601_2029 ENOG4107UJ9 cyclopropane-fatty-acyl-phospholipid synthase JDM601_2035 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) JDM601_2047 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr JDM601_2058 ENOG4105VG9 Plasmid stabilization system JDM601_2059 ENOG41067D0 Antitoxin component of a toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of toxin RelE2 JDM601_2071 ENOG4108UVJ appr-1-p processing domain protein JDM601_2075 ENOG4105CQ7 ATP-dependent helicase JDM601_2077 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) JDM601_2081 ENOG4105F2W methyltransferase JDM601_2082 ENOG4107QM5 aconitate hydratase JDM601_2084 ENOG4108IJ9 (ABC) transporter JDM601_2085 ENOG4105DRS transport system, permease JDM601_2089 ENOG4105E2Y ABC, transporter JDM601_2094 ENOG4108RWI nicotinamidase JDM601_2096 ENOG4105EBR Carboxylesterase JDM601_2100 ENOG4105Q70 JDM601_2101 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) JDM601_2103 ENOG4105EFZ amidohydrolase JDM601_2106 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) JDM601_2109 ENOG4108RG3 short-chain dehydrogenase reductase JDM601_2114 ENOG4105CQR helicase JDM601_2120 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) JDM601_2122 ENOG4105KK4 UPF0060 membrane protein JDM601_2133 ENOG4105DK0 Indole-3-glycerol phosphate synthase JDM601_2135 ENOG4105CRQ synthase (Component I) JDM601_2140 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase JDM601_2141 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) JDM601_2142 ENOG4108MWI inositol mono-phosphatase JDM601_2143 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase JDM601_2156 ENOG41066NP positive regulation by symbiont of host immune response JDM601_2157 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) JDM601_2163 ENOG4107QNE Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) JDM601_2165 ENOG4105EXC Acyl-transferase JDM601_2177 ENOG4108Z4X TRANSCRIPTIONal JDM601_2182 ENOG41084UG Pfam:DUF1458 JDM601_2185 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) JDM601_2186 ENOG4105HDK L-asparaginase JDM601_2190 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) JDM601_2195 ENOG4107RN6 Monooxygenase JDM601_2196 ENOG4105URP P-aminobenzoate N-oxygenase AurF JDM601_2199 ENOG4105E1F short-chain dehydrogenase reductase JDM601_2201 ENOG4107FW0 short-chain dehydrogenase reductase JDM601_2209 ENOG4105RTY Catalyzes diesterification of phthiocerol and phthiodiolone with mycocerosic acids, the final step in the phthiocerol and phthiodiolone dimycocerosate esters (PDIM) synthesis JDM601_2216 ENOG4107RCI amp-dependent synthetase and ligase JDM601_2218 ENOG4108VTW Thioesterase JDM601_2225 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) JDM601_2231 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH JDM601_2232 ENOG4105CHR reductase JDM601_2233 ENOG4107QVM von Willebrand factor, type A JDM601_2235 ENOG4105C7R Atpase associated with various cellular activities aaa_3 JDM601_2237 ENOG4105ZXU NLP P60 protein JDM601_2239 ENOG4107QM5 aconitate hydratase JDM601_2240 ENOG4108Q5F Tetr family transcriptional regulator JDM601_2242 ENOG4105C5H ABC transporter JDM601_2244 ENOG41080RH Thioredoxin JDM601_2247 ENOG4105CI2 imidazolone-5-propionate hydrolase JDM601_2247 ENOG4105CI2 imidazolone-5-propionate hydrolase JDM601_2249 ENOG4105VG1 fes assembly suf system protein JDM601_2250 ENOG4108UNV SUF system FeS assembly protein, NifU family JDM601_2252 ENOG4105C3K feS assembly ATPase SufC JDM601_2256 ENOG4107JC6 Membrane JDM601_2261 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein JDM601_2265 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) JDM601_2268 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) JDM601_2274 ENOG4105CP7 Triose-phosphate isomerase JDM601_2275 ENOG4105BZA Phosphoglycerate kinase JDM601_2276 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase JDM601_2279 ENOG4105CIE May be required for sporulation (By similarity) JDM601_2282 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) JDM601_2285 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) JDM601_2287 ENOG41064B9 (LipO)protein JDM601_2301 ENOG4105F95 Monooxygenase JDM601_2302 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP JDM601_2303 ENOG41060BG Tetr family transcriptional regulator JDM601_2304 ENOG4105CVN desaturase JDM601_2310 ENOG4105SKN orotidine 5''-phosphate decarboxylase JDM601_2312 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain JDM601_2315 ENOG4105CXT aspartate transcarbamylase JDM601_2316 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) JDM601_2318 ENOG4108KC1 acyl-Coa dehydrogenase JDM601_2325 ENOG41080U6 GntR family transcriptional regulator JDM601_2328 ENOG410803B Involved in the transcription termination process (By similarity) JDM601_2330 ENOG4105DC7 peptidase M24 JDM601_2333 ENOG4105D49 3-dehydroquinate synthase JDM601_2338 ENOG4105E2X shikimate dehydrogenase JDM601_2339 ENOG4105HHA aminodeoxychorismate lyase JDM601_2340 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) JDM601_2341 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) JDM601_2342 ENOG4107ZED Uncharacterised protein family UPF0047 JDM601_2343 ENOG4105CI0 Citrate lyase JDM601_2344 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F JDM601_2354 ENOG4105KA0 thioesterase Superfamily protein JDM601_2355 ENOG4105C9M aspartyl-trna synthetase JDM601_2362 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) JDM601_2363 ENOG4108S8N class II Aldolase JDM601_2367 ENOG4105CUT histidyl-tRNA synthetase JDM601_2368 ENOG4107VMB Beta-lactamase domain protein JDM601_2370 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) JDM601_2371 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) JDM601_2372 ENOG4108NY6 Extracellular solute-binding protein, family 5 JDM601_2373 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) JDM601_2379 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) JDM601_2380 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) JDM601_2387 ENOG4105C29 acyl-CoA thioesterase JDM601_2393 ENOG4105E2K Glycosyl transferase (Group 1 JDM601_2397 ENOG4105C22 threonyL-tRNA synthetase JDM601_2399 ENOG4105PMW Domain of unknown function (DUF1990) JDM601_2417 ENOG41084X0 Dihydrofolate reductase JDM601_2420 ENOG4105E0X reductase JDM601_2430 ENOG4108J9M Transporter JDM601_2431 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) JDM601_2432 ENOG4105C0X amino acid JDM601_2433 ENOG4107VEG TrkA-N domain protein JDM601_2439 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) JDM601_2443 ENOG4105DFK Polyphosphate glucokinase JDM601_2460 ENOG4105EUJ GTP cyclohydrolase i JDM601_2465 ENOG4105C1G acyl-Coa dehydrogenase JDM601_2466 ENOG4105C1J atp-dependent rna helicase JDM601_2467 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) JDM601_2468 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) JDM601_2469 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) JDM601_2472 ENOG4105C99 atpase involved in dna repair JDM601_2476 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) JDM601_2477 ENOG4105CDA abc transporter atp-binding protein JDM601_2478 ENOG4107UBR Extracellular solute-binding protein family 3 JDM601_2479 ENOG4108Q1T ABC transporter JDM601_2480 ENOG4105DRP amino acid AbC transporter JDM601_2483 ENOG4107KFM Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) JDM601_2488 ENOG4105MXB limonene-12-epoxide hydrolase JDM601_2494 ENOG4105WBV Transcriptional regulator JDM601_2498 ENOG4107S4F acyltransferase, ws dgat mgat JDM601_2499 ENOG4107QZI cell division protein FtsK JDM601_2508 ENOG4105T0Z Conserved Protein JDM601_2510 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) JDM601_2512 ENOG4105CSH Transporter JDM601_2514 ENOG4105CHR reductase JDM601_2515 ENOG4105C1G acyl-Coa dehydrogenase JDM601_2518 ENOG4107QSV RmuC domain protein JDM601_2519 ENOG4108JIK carboxylase JDM601_2526 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) JDM601_2533 ENOG4107QWG 2-Nitropropane dioxygenase JDM601_2534 ENOG4105C1V Peptidase, M16 JDM601_2535 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) JDM601_2537 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) JDM601_2543 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr JDM601_2547 ENOG4108RF4 Tetr family transcriptional regulator JDM601_2549 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) JDM601_2559 ENOG4105E39 Enoyl-CoA hydratase JDM601_2561 ENOG4105SFS phosphoesterase RecJ domain protein JDM601_2562 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) JDM601_2571 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) JDM601_2574 ENOG4105CSU acyl-Coa dehydrogenase JDM601_2576 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) JDM601_2578 ENOG4105H9W Short-chain dehydrogenase reductase Sdr JDM601_2580 ENOG4108Z86 Glutamine amidotransferase JDM601_2582 ENOG4107RCI amp-dependent synthetase and ligase JDM601_2590 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) JDM601_2597 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs JDM601_2600 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) JDM601_2602 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit JDM601_2606 ENOG4108JPZ Monovalent cation H antiporter subunit D JDM601_2607 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) JDM601_2609 ENOG4105DV0 amidase (EC 3.5.1.4 JDM601_2610 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) JDM601_2614 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) JDM601_2615 ENOG4105DMF Dehydrogenase JDM601_2618 ENOG4105C0P Mg chelatase subunit ChlI JDM601_2619 ENOG41080R2 UPF0102 protein JDM601_2624 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) JDM601_2626 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) JDM601_2627 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) JDM601_2629 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) JDM601_2631 ENOG4105K5M 30s ribosomal protein S16 JDM601_2633 ENOG4105DZ1 carboxypeptidase JDM601_2638 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) JDM601_2646 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) JDM601_2655 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) JDM601_2659 ENOG41087HT growth JDM601_2668 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) JDM601_2669 ENOG4106H78 methyltransferase JDM601_2670 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) JDM601_2674 ENOG4105CV8 reductase JDM601_2677 ENOG4105CB5 ATP-dependent DNA helicase recG JDM601_2678 ENOG4105DP4 dak2 domain fusion protein ylov JDM601_2684 ENOG4105CPF Cell wall formation (By similarity) JDM601_2690 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) JDM601_2691 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) JDM601_2694 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) JDM601_2695 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase JDM601_2696 ENOG4105E5T Major Facilitator Superfamily JDM601_2697 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase JDM601_2698 ENOG4108JPW Aminotransferase JDM601_2699 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) JDM601_2700 ENOG4105EV8 ectoine hydroxylase JDM601_2702 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) JDM601_2706 ENOG4105G3Z GntR family transcriptional regulator JDM601_2708 ENOG4105FUY alpha subunit JDM601_2709 ENOG4108SBK dioxygenase, subunit beta JDM601_2711 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase JDM601_2715 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase JDM601_2716 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase JDM601_2717 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) JDM601_2720 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase JDM601_2721 ENOG4108ZP8 Acetolactate synthase small subunit JDM601_2729 ENOG4105ETU transcriptional activator (TenA JDM601_2732 ENOG4105CTQ phosphohexokinase JDM601_2737 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) JDM601_2741 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) JDM601_2745 ENOG4105CHR reductase JDM601_2748 ENOG4105C10 Electron transfer flavoprotein JDM601_2754 ENOG4105EYF MMPL domain protein JDM601_2755 ENOG4108M8W Monooxygenase JDM601_2758 ENOG4105EVB acetyltransferase JDM601_2759 ENOG4108V0V Pyrrolo-quinoline quinone JDM601_2763 ENOG4105GCF PGAM JDM601_2764 ENOG4105GCF PGAM JDM601_2765 ENOG4105GCF PGAM JDM601_2768 ENOG4105DKW ABC transporter JDM601_2774 ENOG4108MES Periplasmic binding protein JDM601_2776 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) JDM601_2777 ENOG4105DQ4 alcohol dehydrogenase JDM601_2780 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) JDM601_2781 ENOG4107RN6 Monooxygenase JDM601_2782 ENOG4105EJ2 Transcriptional regulator JDM601_2790 ENOG4108YYH Nadph-dependent fmn reductase JDM601_2796 ENOG4105C7K acetolactate synthase JDM601_2797 ENOG4105D2B acyl-CoA dehydrogenase JDM601_2799 ENOG4105D22 carbon starvation protein JDM601_2801 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) JDM601_2802 ENOG41069FZ L,D-transpeptidase catalytic domain JDM601_2803 ENOG4106A3M Cytochrome p-450 JDM601_2806 ENOG4105MP9 class II Aldolase JDM601_2808 ENOG4105C5I Dehydrogenase JDM601_2811 ENOG4105MWK D-amino acid dehydrogenase, small subunit JDM601_2819 ENOG4105EC2 ftsk spoIIIe JDM601_2840 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) JDM601_2842 ENOG4105CAK Cell division ATP-binding protein ftsE JDM601_2844 ENOG4105D8X mechanosensitive ion channel JDM601_2848 ENOG4107TK4 histidinol-phosphate phosphatase JDM601_2850 ENOG4105C1G acyl-Coa dehydrogenase JDM601_2853 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F JDM601_2854 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase JDM601_2856 ENOG4105C1G acyl-Coa dehydrogenase JDM601_2860 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) JDM601_2862 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) JDM601_2865 ENOG4108IEH NADH dehydrogenase subunit g JDM601_2867 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) JDM601_2868 ENOG4105DF2 NADH dehydrogenase subunit j JDM601_2869 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) JDM601_2877 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) JDM601_2885 ENOG4107R5W Monooxygenase JDM601_2887 ENOG4105CRW Short chain fatty acid transporter JDM601_2906 ENOG41063PX domain protein JDM601_2911 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) JDM601_2918 ENOG4108YIQ Alpha beta hydrolase JDM601_2926 ENOG4105C1J atp-dependent rna helicase JDM601_2929 ENOG4108ZM9 phosphoglycerate mutase JDM601_2934 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit JDM601_2940 ENOG4108J08 Csbd family JDM601_2942 ENOG4105CHR reductase JDM601_2943 ENOG4105C1G acyl-Coa dehydrogenase JDM601_2944 ENOG4105C1G acyl-Coa dehydrogenase JDM601_2946 ENOG4107Z3H Transcriptional regulator, TetR family JDM601_2949 ENOG4105CHR reductase JDM601_2952 ENOG41062D9 Histidine kinase JDM601_2953 ENOG4108RQS Two component transcriptional regulator (Winged helix family JDM601_2956 ENOG4108RAV Conserved protein JDM601_2958 ENOG4105DEN Luciferase family JDM601_2968 ENOG4105CSR polyphosphate kinase 2 JDM601_2971 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving JDM601_2972 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea JDM601_2982 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) JDM601_2983 ENOG4107S4F acyltransferase, ws dgat mgat JDM601_2984 ENOG4105G3P Lipoprotein lpqB JDM601_2990 ENOG41084UD rubredoxin JDM601_2991 ENOG4105EEF Alkane 1-monooxygenase JDM601_2992 ENOG4105F8J Adenylate Guanylate cyclase JDM601_2995 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) JDM601_2996 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) JDM601_3004 ENOG4105EIP mannose-6-phosphate isomerase JDM601_3006 ENOG4107QKV phosphomannomutase JDM601_3009 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) JDM601_3011 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) JDM601_3018 ENOG4107TB5 TRANSCRIPTIONal JDM601_3026 ENOG410846T CoA-transferase family III JDM601_3027 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) JDM601_3032 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) JDM601_3033 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit JDM601_3036 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase JDM601_3038 ENOG4105DQE DNA ligase JDM601_3039 ENOG4105D8K carboxyl transferase JDM601_3041 ENOG4107WR6 Maf-like protein JDM601_3045 ENOG4108JIK carboxylase JDM601_3047 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone JDM601_3050 ENOG4105CH6 catalase JDM601_3051 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 JDM601_3058 ENOG4108W6C Dehydrogenase JDM601_3068 ENOG4105KNI merR family transcriptional Regulator JDM601_3071 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) JDM601_3073 ENOG4108UN4 phage SPO1 DNA polymerase-related protein JDM601_3079 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) JDM601_3081 ENOG4105CSH Transporter JDM601_3087 ENOG4105CXN decarboxylase JDM601_3089 ENOG4107RKG DJ-1/PfpI family JDM601_3093 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) JDM601_3098 ENOG4105DIA mandelate racemase muconate lactonizing JDM601_3102 ENOG4108UDB Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) JDM601_3110 ENOG4107NHD transcriptional regulator JDM601_3115 ENOG4107QRT dEAD DEAH box helicase JDM601_3125 ENOG4105C6V Glycerol-3-phosphate dehydrogenase JDM601_3129 ENOG4107RM1 amidohydrolase JDM601_3133 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain JDM601_3148 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) JDM601_3149 ENOG4108KPJ rna polymerase sigma factor JDM601_3152 ENOG4105DZ1 carboxypeptidase JDM601_3154 ENOG4107QNK )-transporter JDM601_3155 ENOG4105CE4 GlcNAc 6-P deacetylase JDM601_3166 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase JDM601_3168 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase JDM601_3169 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) JDM601_3170 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) JDM601_3175 ENOG41061CK Antibiotic biosynthesis monooxygenase JDM601_3178 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) JDM601_3180 ENOG4105CTK cobaltochelatase, cobn subunit JDM601_3182 ENOG4105DQ5 transport system permease protein JDM601_3183 ENOG4105E0A ABC, transporter JDM601_3187 ENOG4105E9K Isocitrate dehydrogenase JDM601_3189 ENOG4108IQK o-acetylhomoserine JDM601_3195 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase JDM601_3196 ENOG4105IDI abc transporter atp-binding protein JDM601_3199 ENOG4105GWZ Roadblock lc7 family protein JDM601_3202 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) JDM601_3205 ENOG4105C0B DNA polymerase III (alpha subunit) JDM601_3210 ENOG4105C1G acyl-Coa dehydrogenase JDM601_3213 ENOG4105GCF PGAM JDM601_3214 ENOG4105PDP Short chain dehydrogenase JDM601_3218 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) JDM601_3222 ENOG4107QVP Dehydrogenase JDM601_3225 ENOG4108VT4 JDM601_3227 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) JDM601_3230 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase JDM601_3237 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) JDM601_3238 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) JDM601_3245 ENOG4105CVK Glutamate decarboxylase JDM601_3249 ENOG4105CHR reductase JDM601_3251 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) JDM601_3253 ENOG4107RCI amp-dependent synthetase and ligase JDM601_3259 ENOG4105DYW oxidoreductase JDM601_3262 ENOG4107RCI amp-dependent synthetase and ligase JDM601_3263 ENOG4105RYD Toxic component of a toxin-antitoxin (TA) module. A JDM601_3267 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) JDM601_3268 ENOG4108UJD 30S ribosomal protein S9 JDM601_3269 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) JDM601_3273 ENOG4105EC2 ftsk spoIIIe JDM601_3275 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin JDM601_3278 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) JDM601_3279 ENOG4108ZT0 50S ribosomal protein l17 JDM601_3280 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) JDM601_3281 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) JDM601_3282 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) JDM601_3283 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits JDM601_3287 ENOG4105C1B dTDP-glucose 4-6-dehydratase JDM601_3291 ENOG4105C26 Dehydrogenase JDM601_3292 ENOG4105C1G acyl-Coa dehydrogenase JDM601_3296 ENOG4105WH1 Two component transcriptional regulator luxr family JDM601_3300 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) JDM601_3303 ENOG4106N8J Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) JDM601_3313 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) JDM601_3314 ENOG410849U 50S ribosomal protein L30 JDM601_3315 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) JDM601_3316 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) JDM601_3317 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) JDM601_3318 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) JDM601_3320 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits JDM601_3322 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) JDM601_3323 ENOG4105E6M Sulphatase-modifying factor protein JDM601_3324 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) JDM601_3325 ENOG4106NZI LysR family Transcriptional regulator JDM601_3330 ENOG41082SA 50s ribosomal protein l29 JDM601_3331 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) JDM601_3332 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) JDM601_3333 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) JDM601_3334 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) JDM601_3335 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity JDM601_3336 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) JDM601_3338 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) JDM601_3341 ENOG4105EBR Carboxylesterase JDM601_3343 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) JDM601_3349 ENOG4105XDV JDM601_3356 ENOG4107S2E monooxygenase JDM601_3357 ENOG4108K3M Rieske [2Fe-2S] domain JDM601_3359 ENOG4107RGH Aldehyde dehydrogenase JDM601_3364 ENOG4106A3M Cytochrome p-450 JDM601_3368 ENOG4105C1B dTDP-glucose 4-6-dehydratase JDM601_3370 ENOG4105CHU acetyl-coa acetyltransferase JDM601_3376 ENOG4105D2B acyl-CoA dehydrogenase JDM601_3382 ENOG4106USH transcriptional modulator of maze toxin, mazf JDM601_3386 ENOG4105X7H acyl-CoA dehydrogenase JDM601_3387 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase JDM601_3390 ENOG41080W3 amp-dependent synthetase and ligase JDM601_3392 ENOG4108UKI Enoyl-CoA hydratase JDM601_3394 ENOG4105E39 Enoyl-CoA hydratase JDM601_3396 ENOG4105CHU acetyl-coa acetyltransferase JDM601_3397 ENOG4105E39 Enoyl-CoA hydratase JDM601_3399 ENOG4105CGU Enoyl-CoA hydratase JDM601_3400 ENOG4105E39 Enoyl-CoA hydratase JDM601_3403 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_3404 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_3406 ENOG4108WYP Transcriptional regulator JDM601_3408 ENOG4105C1G acyl-Coa dehydrogenase JDM601_3409 ENOG4105CHU acetyl-coa acetyltransferase JDM601_3411 ENOG4105C1G acyl-Coa dehydrogenase JDM601_3412 ENOG41076PI Short-chain dehydrogenase reductase Sdr JDM601_3414 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_3418 ENOG4105GMT ATPase associated with various cellular activities aaa_5 JDM601_3424 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_3426 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_3428 ENOG4105E39 Enoyl-CoA hydratase JDM601_3431 ENOG41076PI Short-chain dehydrogenase reductase Sdr JDM601_3446 ENOG4108IG5 Transcriptional regulator JDM601_3454 ENOG4108QIU Dehydrogenase JDM601_3456 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein JDM601_3457 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) JDM601_3458 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase JDM601_3459 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) JDM601_3461 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein JDM601_3477 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F JDM601_3480 ENOG4105CHR reductase JDM601_3481 ENOG41076PI Short-chain dehydrogenase reductase Sdr JDM601_3484 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_3485 ENOG4105D2B acyl-CoA dehydrogenase JDM601_3491 ENOG4107EEP NADH dehydrogenase (quinone) (EC 1.6.99.5) JDM601_3496 ENOG4106A3M Cytochrome p-450 JDM601_3503 ENOG4105DVW rieske (2Fe-2S) JDM601_3507 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_3508 ENOG4105D2B acyl-CoA dehydrogenase JDM601_3509 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_3511 ENOG4105C26 Dehydrogenase JDM601_3512 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) JDM601_3515 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_3516 ENOG4105D2B acyl-CoA dehydrogenase JDM601_3517 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_3522 ENOG4107R5W Monooxygenase JDM601_3524 ENOG4105H9W Short-chain dehydrogenase reductase Sdr JDM601_3530 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) JDM601_3532 ENOG4105E2Z phosphate ABC transporter (Permease JDM601_3535 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) JDM601_3541 ENOG4107NHD transcriptional regulator JDM601_3543 ENOG4105K63 Thioredoxin JDM601_3545 ENOG4105KHC sulfurtransferase JDM601_3546 ENOG4105PKJ carbohydrate binding JDM601_3547 ENOG4108SVG May play a role in the intracellular transport of hydrophobic ligands JDM601_3552 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_3553 ENOG4105D2B acyl-CoA dehydrogenase JDM601_3557 ENOG4105CHR reductase JDM601_3558 ENOG4108IG5 Transcriptional regulator JDM601_3560 ENOG4105GMT ATPase associated with various cellular activities aaa_5 JDM601_3562 ENOG4105FAE von Willebrand factor, type A JDM601_3571 ENOG4105EZR dyp-type peroxidase family protein JDM601_3574 ENOG410839H phosphoribosylformylglycinamidine synthase JDM601_3575 ENOG4107T8T UPF0173 metal-dependent hydrolase JDM601_3578 ENOG4105EXU Membrane JDM601_3579 ENOG4108V06 Glutathione peroxidase JDM601_3581 ENOG4105C8V SAICAR synthetase JDM601_3587 ENOG4105C83 adenylosuccinate lyase JDM601_3588 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) JDM601_3589 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) JDM601_3596 ENOG4105E39 Enoyl-CoA hydratase JDM601_3600 ENOG4105C26 Dehydrogenase JDM601_3603 ENOG4107GJV short-chain dehydrogenase reductase JDM601_3604 ENOG41068W2 Cytochrome p-450 JDM601_3609 ENOG4106A3M Cytochrome p-450 JDM601_3613 ENOG4105BZU Histidine kinase JDM601_3614 ENOG4105CK6 Two component transcriptional regulator (Winged helix family JDM601_3617 ENOG4108QIU Dehydrogenase JDM601_3621 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase JDM601_3633 ENOG4105CHR reductase JDM601_3635 ENOG4105X7H acyl-CoA dehydrogenase JDM601_3636 ENOG4108KC2 acyl-Coa dehydrogenase JDM601_3637 ENOG4105HMD JDM601_3642 ENOG4105BZ1 (ABC) transporter JDM601_3646 ENOG4105C26 Dehydrogenase JDM601_3649 ENOG4106YT9 Enoyl-CoA hydratase JDM601_3650 ENOG4105CMR udp-glucose 4-epimerase JDM601_3652 ENOG410719E cytochrome p450 JDM601_3659 ENOG4105DYW oxidoreductase JDM601_3662 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) JDM601_3667 ENOG4108Z0R Transferase JDM601_3668 ENOG4105CIJ rieske 2fe-2S domain-containing protein JDM601_3678 ENOG4105C9U ATP-dependent DNA helicase RecQ JDM601_3679 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) JDM601_3683 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein JDM601_3689 ENOG410900P UPF0336 protein JDM601_3690 ENOG4105X7H acyl-CoA dehydrogenase JDM601_3691 ENOG4108RK3 acyl-Coa dehydrogenase JDM601_3694 ENOG4105F2C Acetyl-CoA acetyltransferase JDM601_3702 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr JDM601_3703 ENOG4105H9W Short-chain dehydrogenase reductase Sdr JDM601_3704 ENOG4105E39 Enoyl-CoA hydratase JDM601_3713 ENOG4105F2C Acetyl-CoA acetyltransferase JDM601_3715 ENOG4105CHR reductase JDM601_3716 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_3717 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_3718 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_3719 ENOG4105C1G acyl-Coa dehydrogenase JDM601_3720 ENOG4105D2B acyl-CoA dehydrogenase JDM601_3730 ENOG4105PDP Short chain dehydrogenase JDM601_3734 ENOG4106A3M Cytochrome p-450 JDM601_3736 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme JDM601_3745 ENOG4105CHU acetyl-coa acetyltransferase JDM601_3750 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr JDM601_3752 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F JDM601_3754 ENOG4105E39 Enoyl-CoA hydratase JDM601_3756 ENOG4105C1G acyl-Coa dehydrogenase JDM601_3758 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) JDM601_3759 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_3761 ENOG4107QX3 carboxylase JDM601_3764 ENOG4105C1G acyl-Coa dehydrogenase JDM601_3767 ENOG4105X7H acyl-CoA dehydrogenase JDM601_3768 ENOG4105FGE Short-chain dehydrogenase reductase Sdr JDM601_3769 ENOG4105CMM transposase JDM601_3777 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_3778 ENOG4105C1G acyl-Coa dehydrogenase JDM601_3804 ENOG4106A3M Cytochrome p-450 JDM601_3810 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_3811 ENOG4105C1G acyl-Coa dehydrogenase JDM601_3812 ENOG4108UKI Enoyl-CoA hydratase JDM601_3813 ENOG4105K6S Short-chain dehydrogenase reductase Sdr JDM601_3815 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) JDM601_3816 ENOG41076PI Short-chain dehydrogenase reductase Sdr JDM601_3824 ENOG41061TZ Short-chain dehydrogenase reductase Sdr JDM601_3829 ENOG4105D2B acyl-CoA dehydrogenase JDM601_3840 ENOG4105CC9 acyl-Coa dehydrogenase JDM601_3842 ENOG4105CHU acetyl-coa acetyltransferase JDM601_3844 ENOG4105X7H acyl-CoA dehydrogenase JDM601_3845 ENOG4106YT9 Enoyl-CoA hydratase JDM601_3863 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) JDM601_3865 ENOG4105D2B acyl-CoA dehydrogenase JDM601_3866 ENOG4108SGK Tetr family transcriptional regulator JDM601_3869 ENOG4107R5R arsenical pump membrane protein JDM601_3870 ENOG4105C2N RNA methyltransferase TrmH family group 3 JDM601_3875 ENOG4108VJ1 Transcriptional regulator (CarD family JDM601_3880 ENOG4108V9Q carbonic anhydrase JDM601_3888 ENOG4105CRK lysyL-tRNA synthetase JDM601_3889 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) JDM601_3890 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) JDM601_3891 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) JDM601_3897 ENOG4105EEI dihydropteroate synthase JDM601_3898 ENOG4105EUJ GTP cyclohydrolase i JDM601_3900 ENOG4105D74 hydrolase JDM601_3902 ENOG4105CPQ Dehydrogenase JDM601_3906 ENOG4108UGV hypoxanthine phosphoribosyltransferase JDM601_3907 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) JDM601_3909 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase JDM601_3927 ENOG4105CK6 Two component transcriptional regulator (Winged helix family JDM601_3928 ENOG4105BZU Histidine kinase JDM601_3929 ENOG4105C6E dna polymerase iii JDM601_3933 ENOG4105VEQ Cold shock protein JDM601_3934 ENOG4108I5C dEAD DEAH box helicase JDM601_3945 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) JDM601_3950 ENOG4105P8F nudix hydrolase JDM601_3951 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen JDM601_3955 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) JDM601_3960 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) JDM601_3961 ENOG4105BZ4 penicillin-binding protein JDM601_3962 ENOG4107RGJ metallophosphoesterase JDM601_3965 ENOG4105BZP glycoside hydrolase 15-related JDM601_3970 ENOG4108WQ6 secreted protein JDM601_3971 ENOG4105C7R Atpase associated with various cellular activities aaa_3 JDM601_3975 ENOG4105NTW Transcriptional regulator JDM601_3977 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) JDM601_3979 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase JDM601_3983 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process JDM601_3984 ENOG4105D1K glutamate--cysteine ligase JDM601_3986 ENOG4108ZHJ Organic hydroperoxide resistance protein JDM601_3987 ENOG4105CH6 catalase JDM601_3989 ENOG4108NJC JDM601_3991 ENOG4105CFH Aspartokinase JDM601_3993 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) JDM601_3994 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) JDM601_3995 ENOG4105DMS mur ligase JDM601_3998 ENOG4105EEF Alkane 1-monooxygenase JDM601_3999 ENOG41084UD rubredoxin JDM601_4000 ENOG4105VCQ rubredoxin JDM601_4003 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) JDM601_4004 ENOG41085QW Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) JDM601_4005 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase JDM601_4007 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase JDM601_4009 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase JDM601_4012 ENOG4105XT2 Transcriptional regulator JDM601_4022 ENOG4105DQE DNA ligase JDM601_4023 ENOG4105GN4 DNA ligase JDM601_4024 ENOG4108J2P Alpha beta hydrolase fold JDM601_4030 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase JDM601_4033 ENOG4108Z6B deaminase JDM601_4036 ENOG4105EVN Prephenate dehydrogenase JDM601_4037 ENOG41060H3 Protein of unknown function (DUF1049) JDM601_4041 ENOG4105BZU Histidine kinase JDM601_4042 ENOG4105CK6 Two component transcriptional regulator (Winged helix family JDM601_4045 ENOG4105CH2 amidohydrolase JDM601_4050 ENOG4105CIH Imidazole acetol-phosphate transaminase JDM601_4061 ENOG4105DND Transcriptional regulator JDM601_4077 ENOG4107RCI amp-dependent synthetase and ligase JDM601_4082 ENOG4108MKI Glycosyl transferase, family 2 JDM601_4085 ENOG410839S Toxic component of a toxin-antitoxin (TA) module (By similarity) JDM601_4086 ENOG4105DIA mandelate racemase muconate lactonizing JDM601_4098 ENOG4105IQ5 FAD linked oxidase domain protein JDM601_4099 ENOG4108RG3 short-chain dehydrogenase reductase JDM601_4105 ENOG4105J1Z Arabinosyltransferase JDM601_4110 ENOG4105CSH Transporter JDM601_4114 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) JDM601_4115 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) JDM601_4116 ENOG4105D8K carboxyl transferase JDM601_4118 ENOG4107RCI amp-dependent synthetase and ligase JDM601_4123 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids JDM601_4124 ENOG4106YN8 Prenyltransferase JDM601_4126 ENOG410602S Transferase JDM601_4134 ENOG4107B57 rieske 2fe-2S domain-containing protein JDM601_4139 ENOG4108IG5 Transcriptional regulator JDM601_4142 ENOG4108XG4 DNA-binding transcriptional regulator JDM601_4143 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) JDM601_4153 ENOG4108KGH TRANSCRIPTIONal JDM601_4158 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) JDM601_4167 ENOG4105DFA alanine racemase domain protein JDM601_4168 ENOG4105CT3 Monooxygenase JDM601_4171 ENOG4105CT3 Monooxygenase JDM601_4172 ENOG41060BG Tetr family transcriptional regulator JDM601_4176 ENOG4105CBC glutamate synthase JDM601_4181 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F JDM601_4189 ENOG4105E4E Thioester reductase domain-containing protein JDM601_4190 ENOG4105EXC Acyl-transferase JDM601_4192 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) JDM601_4201 ENOG4105C26 Dehydrogenase JDM601_4210 ENOG4105CIR epoxide hydrolase JDM601_4212 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit JDM601_4216 ENOG4105YIP Tetr family transcriptional regulator JDM601_4221 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) JDM601_4227 ENOG410900P UPF0336 protein JDM601_4232 ENOG4105EMU Dehydrogenase JDM601_4237 ENOG4108WKN secreted protein JDM601_4239 ENOG4105CHR reductase JDM601_4240 ENOG4105C26 Dehydrogenase JDM601_4242 ENOG4105C29 acyl-CoA thioesterase JDM601_4244 ENOG4108SGK Tetr family transcriptional regulator JDM601_4245 ENOG4108QIU Dehydrogenase JDM601_4247 ENOG4107S2E monooxygenase JDM601_4250 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase JDM601_4254 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase JDM601_4257 ENOG4105CHR reductase JDM601_4259 ENOG4105CEY Amp-dependent synthetase and ligase JDM601_4260 ENOG4105CPQ Dehydrogenase JDM601_4262 ENOG4105E39 Enoyl-CoA hydratase JDM601_4263 ENOG4105D2B acyl-CoA dehydrogenase JDM601_4266 ENOG4105H9W Short-chain dehydrogenase reductase Sdr JDM601_4271 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein JDM601_4274 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein JDM601_4287 ENOG4105CY3 ABC transporter, permease JDM601_4292 ENOG4108WKN secreted protein JDM601_4293 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) JDM601_4300 ENOG4107S1E Beta-lactamase JDM601_4301 ENOG4105CKI cobalamin synthesis protein JDM601_4306 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) JDM601_4307 ENOG4107YH6 single-stranded DNA-binding protein JDM601_4308 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) JDM601_4310 ENOG4105BZ4 penicillin-binding protein JDM601_4311 ENOG4105BZ4 penicillin-binding protein JDM601_4315 ENOG4105CZA synthase JDM601_4316 ENOG4108YIQ Alpha beta hydrolase JDM601_4318 ENOG4105DRP amino acid AbC transporter JDM601_4321 ENOG4108IXY short-chain dehydrogenase reductase JDM601_4324 ENOG41064CH Probable lipoprotein LpqN JDM601_4326 ENOG41081DT UPF0301 protein JDM601_4327 ENOG4108M0D major facilitator superfamily JDM601_4331 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate JDM601_4340 ENOG4108E1C hydrolase JDM601_4342 ENOG4107QJE Chromosome Partitioning Protein JDM601_4344 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins JDM601_tRNA19 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation