locus-tag class description MAIC_00050 ENOG4108IG5 Transcriptional regulator MAIC_00220 ENOG4105C6V Glycerol-3-phosphate dehydrogenase MAIC_00230 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) MAIC_00240 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) MAIC_00250 ENOG4108K8U Glycerol operon regulatory protein MAIC_00260 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) MAIC_00290 ENOG4105K56 Transcriptional regulator MAIC_00390 ENOG4105KPY Small multidrug resistance protein MAIC_00510 ENOG4105BZU Histidine kinase MAIC_00530 ENOG4105CUB amino acid MAIC_00540 ENOG4105BZU Histidine kinase MAIC_00550 ENOG4105BZU Histidine kinase MAIC_00560 ENOG4105BZU Histidine kinase MAIC_00570 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) MAIC_00580 ENOG410900P UPF0336 protein MAIC_00610 ENOG4105H9W Short-chain dehydrogenase reductase Sdr MAIC_00620 ENOG4106NZI LysR family Transcriptional regulator MAIC_00640 ENOG4105CHR reductase MAIC_00650 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) MAIC_00690 ENOG4105CB5 ATP-dependent DNA helicase recG MAIC_00710 ENOG4105CSH Transporter MAIC_00770 ENOG4108WKN secreted protein MAIC_00860 ENOG4105D2B acyl-CoA dehydrogenase MAIC_00880 ENOG4108SGK Tetr family transcriptional regulator MAIC_00980 ENOG4105EMN RNA polymerase sigma factor MAIC_00990 ENOG4105CHR reductase MAIC_01020 ENOG41062IE glyoxalase bleomycin resistance protein dioxygenase MAIC_01070 ENOG4108VEQ Superoxide dismutase MAIC_01090 ENOG4108J08 Csbd family MAIC_01180 ENOG4105CE4 GlcNAc 6-P deacetylase MAIC_01190 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) MAIC_01200 ENOG4105C5Y PTS System MAIC_01210 ENOG4105CI1 PTS System MAIC_01250 ENOG4105CHR reductase MAIC_01320 ENOG4105CQ7 ATP-dependent helicase MAIC_01360 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MAIC_01380 ENOG4105D2B acyl-CoA dehydrogenase MAIC_01390 ENOG4105D2B acyl-CoA dehydrogenase MAIC_01550 ENOG4106F1P AAA ATPase, central domain protein MAIC_01570 ENOG4107U53 septum site-determining protein minD MAIC_01580 ENOG4105CBC glutamate synthase MAIC_01620 ENOG4105CHH sulfate transporter MAIC_01640 ENOG4105DCG PHP domain protein MAIC_01650 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) MAIC_01660 ENOG4105BZ4 penicillin-binding protein MAIC_01680 ENOG4105CT3 Monooxygenase MAIC_01690 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) MAIC_01840 ENOG4108KGH TRANSCRIPTIONal MAIC_01870 ENOG4105CQC Prephenate dehydratase MAIC_01990 ENOG4105PSQ Acyl-transferase MAIC_02000 ENOG4105E9Q Acyl-transferase MAIC_02050 ENOG410602S Transferase MAIC_02070 ENOG4106YN8 Prenyltransferase MAIC_02080 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids MAIC_02160 ENOG4105D8K carboxyl transferase MAIC_02170 ENOG4107QY8 reductase MAIC_02180 ENOG4105EX0 alpha-galactosidase MAIC_02260 ENOG4105J1Z Arabinosyltransferase MAIC_02270 ENOG4108NUW Cell wall arabinan synthesis protein MAIC_02280 ENOG4105J1Z Arabinosyltransferase MAIC_02300 ENOG4108RG3 short-chain dehydrogenase reductase MAIC_02310 ENOG4105IQ5 FAD linked oxidase domain protein MAIC_02360 ENOG4108MKI Glycosyl transferase, family 2 MAIC_02380 ENOG4108VC7 Protein of unknown function (DUF2587) MAIC_02410 ENOG4105CPQ Dehydrogenase MAIC_02500 ENOG4105EXC Acyl-transferase MAIC_02520 ENOG4107SCK Monooxygenase MAIC_02570 ENOG4105CHR reductase MAIC_02580 ENOG4105C1G acyl-Coa dehydrogenase MAIC_02630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MAIC_02640 ENOG4105BZU Histidine kinase MAIC_02650 ENOG4105EDW glycosyl transferase, family 39 MAIC_02670 ENOG4105EDW glycosyl transferase, family 39 MAIC_02670 ENOG4105EDW glycosyl transferase, family 39 MAIC_02700 ENOG4105EUZ Beta-lactamase domain protein MAIC_02740 ENOG4105CHR reductase MAIC_02790 ENOG41060H3 Protein of unknown function (DUF1049) MAIC_02810 ENOG4108IJ8 ABC transporter MAIC_02820 ENOG4105E90 ABC transporter MAIC_02830 ENOG4105E90 ABC transporter MAIC_02850 ENOG4105EVN Prephenate dehydrogenase MAIC_02870 ENOG4108Z6B deaminase MAIC_02950 ENOG4108J2P Alpha beta hydrolase fold MAIC_02960 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) MAIC_02970 ENOG4106A3M Cytochrome p-450 MAIC_03000 ENOG4105CDA abc transporter atp-binding protein MAIC_03010 ENOG4105DRP amino acid AbC transporter MAIC_03020 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) MAIC_03050 ENOG4108UQY Iron-storage protein MAIC_03060 ENOG4105XTG Pfam:DUF156 MAIC_03100 ENOG4105D9P serine threonine protein kinase MAIC_03200 ENOG4105XT2 Transcriptional regulator MAIC_03230 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase MAIC_03260 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase MAIC_03270 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) MAIC_03290 ENOG4105BZU Histidine kinase MAIC_03320 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) MAIC_03330 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) MAIC_03340 ENOG4105BZU Histidine kinase MAIC_03400 ENOG4105MWK D-amino acid dehydrogenase, small subunit MAIC_03410 ENOG4105CBC glutamate synthase MAIC_03420 ENOG4105M90 Glutamate synthase alpha subunit domain protein MAIC_03430 ENOG4105EYU Glutamine amido-transferase MAIC_03470 ENOG4105FG0 Nitroreductase MAIC_03480 ENOG4105CFH Aspartokinase MAIC_03500 ENOG4108NJC MAIC_03540 ENOG4105CH6 catalase MAIC_03550 ENOG4108ZHJ Organic hydroperoxide resistance protein MAIC_03570 ENOG4105D1K glutamate--cysteine ligase MAIC_03580 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process MAIC_03590 ENOG4108V75 Glutamine amidotransferase MAIC_03600 ENOG41067HS methyltransferase MAIC_03610 ENOG4105C92 Aminotransferase class V MAIC_03680 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) MAIC_03690 ENOG4105D6F Phosphatase MAIC_03730 ENOG4105CYX Short-chain dehydrogenase reductase Sdr MAIC_03830 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MAIC_03840 ENOG4108WQ6 secreted protein MAIC_03890 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MAIC_03920 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) MAIC_03990 ENOG4105CYX Short-chain dehydrogenase reductase Sdr MAIC_04000 ENOG4108W5M transcriptional regulator MAIC_04020 ENOG4107RGJ metallophosphoesterase MAIC_04030 ENOG4108JQC penicillin-binding protein 1A MAIC_04090 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) MAIC_04120 ENOG4105CSM endonuclease III MAIC_04130 ENOG4105K63 Thioredoxin MAIC_04140 ENOG4105P8F nudix hydrolase MAIC_04160 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) MAIC_04190 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) MAIC_04300 ENOG4108I5C dEAD DEAH box helicase MAIC_04310 ENOG4105VEQ Cold shock protein MAIC_04330 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) MAIC_04350 ENOG4107QRG dna polymerase iii MAIC_04360 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase MAIC_04400 ENOG4108PBI Polysaccharide metabolism MAIC_04540 ENOG4107XI7 Tetr family transcriptional regulator MAIC_04620 ENOG4108UGV hypoxanthine phosphoribosyltransferase MAIC_04630 ENOG4105WH1 Two component transcriptional regulator luxr family MAIC_04680 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein MAIC_04700 ENOG4105D74 hydrolase MAIC_04720 ENOG4105EUJ GTP cyclohydrolase i MAIC_04730 ENOG4105EEI dihydropteroate synthase MAIC_04790 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) MAIC_04800 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) MAIC_04810 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) MAIC_04830 ENOG4105CRK lysyL-tRNA synthetase MAIC_04850 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit MAIC_04860 ENOG41082VC UPF0145 protein MAIC_04950 ENOG4105CEN a g-specific adenine glycosylase MAIC_04980 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) MAIC_04990 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) MAIC_05010 ENOG4108VJ1 Transcriptional regulator (CarD family MAIC_05020 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) MAIC_05030 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) MAIC_05040 ENOG4105C8N cysteinyl-tRNA synthetase MAIC_05050 ENOG4105C2N RNA methyltransferase TrmH family group 3 MAIC_05090 ENOG4105CC5 ABC transporter MAIC_05100 ENOG4105DIK (ABC) transporter MAIC_05140 ENOG4108SGK Tetr family transcriptional regulator MAIC_05150 ENOG4105D2B acyl-CoA dehydrogenase MAIC_05180 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase MAIC_05240 ENOG4105CHM Aminotransferase MAIC_05260 ENOG4105D2B acyl-CoA dehydrogenase MAIC_05270 ENOG4105D2B acyl-CoA dehydrogenase MAIC_05280 ENOG4105CC9 acyl-Coa dehydrogenase MAIC_05290 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_05300 ENOG4105CC9 acyl-Coa dehydrogenase MAIC_05320 ENOG4108RZE Tetr family transcriptional regulator MAIC_05330 ENOG4105F2C Acetyl-CoA acetyltransferase MAIC_05380 ENOG4105EA8 2-Nitropropane dioxygenase MAIC_05410 ENOG4105E39 Enoyl-CoA hydratase MAIC_05430 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr MAIC_05460 ENOG4105ETS cytosine purines uracil thiamine allantoin MAIC_05490 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MAIC_05500 ENOG410839U amino acid MAIC_05510 ENOG4108VW9 Membrane MAIC_05520 ENOG4105C26 Dehydrogenase MAIC_05540 ENOG4105H3G oxidoreductase MAIC_05550 ENOG4105KME endoribonuclease L-psp MAIC_05570 ENOG4107RM1 amidohydrolase MAIC_05580 ENOG4108IJ0 Aspartate ammonia-lyase MAIC_05620 ENOG4105F2C Acetyl-CoA acetyltransferase MAIC_05640 ENOG4108RK3 acyl-Coa dehydrogenase MAIC_05650 ENOG4105X7H acyl-CoA dehydrogenase MAIC_05660 ENOG410900P UPF0336 protein MAIC_05720 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein MAIC_05750 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) MAIC_05760 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) MAIC_05770 ENOG4105C9U ATP-dependent DNA helicase RecQ MAIC_05860 ENOG4105CIJ rieske 2fe-2S domain-containing protein MAIC_05880 ENOG4105X1P Steroid delta-isomerase MAIC_05930 ENOG4105DYW oxidoreductase MAIC_05950 ENOG410719E cytochrome p450 MAIC_05970 ENOG4105E39 Enoyl-CoA hydratase MAIC_06030 ENOG4105J5T Amp-dependent synthetase and ligase MAIC_06040 ENOG4108KC2 acyl-Coa dehydrogenase MAIC_06050 ENOG4105X7H acyl-CoA dehydrogenase MAIC_06070 ENOG4105CHR reductase MAIC_06080 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase MAIC_06140 ENOG4106KE4 Dehydrogenase MAIC_06150 ENOG4107TB5 TRANSCRIPTIONal MAIC_06300 ENOG4105C1G acyl-Coa dehydrogenase MAIC_06330 ENOG4105CHR reductase MAIC_06350 ENOG4105BZU Histidine kinase MAIC_06370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MAIC_06380 ENOG4105BZU Histidine kinase MAIC_06410 ENOG4105EDW glycosyl transferase, family 39 MAIC_06440 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MAIC_06480 ENOG41068W2 Cytochrome p-450 MAIC_06490 ENOG4105EMU Dehydrogenase MAIC_06520 ENOG4105C26 Dehydrogenase MAIC_06600 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) MAIC_06630 ENOG4105CHP RNA polymerase MAIC_06670 ENOG4106A3M Cytochrome p-450 MAIC_06680 ENOG4107QX3 carboxylase MAIC_06730 ENOG4105CHR reductase MAIC_06750 ENOG4105C83 adenylosuccinate lyase MAIC_06920 ENOG4105CHR reductase MAIC_06950 ENOG410839H phosphoribosylformylglycinamidine synthase MAIC_06960 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I MAIC_06980 ENOG4105EZR dyp-type peroxidase family protein MAIC_06990 ENOG4105DFM M18 family aminopeptidase MAIC_07010 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii MAIC_07070 ENOG4105CGD Nad-dependent epimerase dehydratase MAIC_07100 ENOG4105CXB phosphoribosylaminoimidazole synthetase MAIC_07170 ENOG4105PKJ carbohydrate binding MAIC_07180 ENOG4105KHC sulfurtransferase MAIC_07220 ENOG4107NHD transcriptional regulator MAIC_07230 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) MAIC_07270 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) MAIC_07360 ENOG4105D3Q Sugar transferase MAIC_07380 ENOG4105CHR reductase MAIC_07400 ENOG4105H3G oxidoreductase MAIC_07420 ENOG4108BAS reductase MAIC_07430 ENOG4105C1G acyl-Coa dehydrogenase MAIC_07450 ENOG4105CHU acetyl-coa acetyltransferase MAIC_07460 ENOG4105C1G acyl-Coa dehydrogenase MAIC_07490 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_07520 ENOG4106YT9 Enoyl-CoA hydratase MAIC_07530 ENOG4105E39 Enoyl-CoA hydratase MAIC_07540 ENOG4105C6F GntR Family Transcriptional Regulator MAIC_07550 ENOG4105E39 Enoyl-CoA hydratase MAIC_07640 ENOG4105X7H acyl-CoA dehydrogenase MAIC_07660 ENOG4105X7H acyl-CoA dehydrogenase MAIC_07680 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F MAIC_07710 ENOG4105WH1 Two component transcriptional regulator luxr family MAIC_07740 ENOG4105C26 Dehydrogenase MAIC_07750 ENOG4105E2A Dehydrogenase MAIC_07770 ENOG4108J2R molybdopterin oxidoreductase MAIC_07780 ENOG410846T CoA-transferase family III MAIC_07790 ENOG4105C26 Dehydrogenase MAIC_07800 ENOG41076PI Short-chain dehydrogenase reductase Sdr MAIC_07810 ENOG4106A3M Cytochrome p-450 MAIC_07850 ENOG4107S2E monooxygenase MAIC_07870 ENOG4105MKU Transcriptional regulator MAIC_07930 ENOG4105D8K carboxyl transferase MAIC_07960 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MAIC_08050 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F MAIC_08090 ENOG4105CHU acetyl-coa acetyltransferase MAIC_08100 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase MAIC_08110 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_08120 ENOG4108M8W Monooxygenase MAIC_08140 ENOG4105CHU acetyl-coa acetyltransferase MAIC_08160 ENOG4105CFI type iii restriction protein res subunit MAIC_08200 ENOG4108RIR Molybdenum cofactor biosynthesis protein MAIC_08250 ENOG410901E Membrane MAIC_08260 ENOG4105VEQ Cold shock protein MAIC_08270 ENOG4105CHF Glutathione S-transferase MAIC_08310 ENOG4108N0W Major Facilitator superfamily MAIC_08440 ENOG4105CSH Transporter MAIC_08510 ENOG4105C57 major facilitator superfamily MAIC_08520 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) MAIC_08560 ENOG4105KKJ Aminoglycoside phosphotransferase MAIC_08570 ENOG4105CHR reductase MAIC_08580 ENOG4105FDP GntR family transcriptional regulator MAIC_08590 ENOG41081K0 peptidylprolyl cis-trans isomerase MAIC_08640 ENOG4105F9U Dehydrogenase MAIC_08680 ENOG4107Z3H Transcriptional regulator, TetR family MAIC_08700 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr MAIC_08730 ENOG4105BZ1 (ABC) transporter MAIC_08740 ENOG4105BZ1 (ABC) transporter MAIC_08750 ENOG4105D74 hydrolase MAIC_08810 ENOG4107S1E Beta-lactamase MAIC_08820 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic MAIC_08930 ENOG4105C5H ABC transporter MAIC_08960 ENOG4105BZU Histidine kinase MAIC_09050 ENOG4108M8W Monooxygenase MAIC_09060 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) MAIC_09080 ENOG4105K6V RNA polymerase MAIC_09180 ENOG4105FDF Could be involved in DNA repair (By similarity) MAIC_09200 ENOG4105DQE DNA ligase MAIC_09210 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) MAIC_09230 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) MAIC_09290 ENOG4107UWP Major facilitator superfamily MFS_1 MAIC_09310 ENOG41082T9 Membrane MAIC_09380 ENOG4105EXC Acyl-transferase MAIC_09430 ENOG4105CMV Succinyl-CoA synthetase subunit beta MAIC_09470 ENOG4105FBW Monooxygenase MAIC_09480 ENOG41078VV 34 kDa antigenic protein MAIC_09560 ENOG41060WC Enoyl-CoA hydratase MAIC_09590 ENOG4107QX3 carboxylase MAIC_09620 ENOG41067C8 50S ribosomal protein L32 MAIC_09650 ENOG4105C0H protease MAIC_09660 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) MAIC_09740 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase MAIC_09750 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase MAIC_09830 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) MAIC_09900 ENOG4105GCF PGAM MAIC_09930 ENOG4107R13 MMPL domain protein MAIC_09960 ENOG4105P52 geranylgeranyl reductase MAIC_09970 ENOG4105CHR reductase MAIC_09990 ENOG410870F Cyclic nucleotide-binding protein MAIC_10000 ENOG4105F9E Shikimate 5-dehydrogenase MAIC_10050 ENOG4105KAV tspo and mbr like protein MAIC_10100 ENOG4108Z4X TRANSCRIPTIONal MAIC_10110 ENOG4105CEU Arginine dihydrolase MAIC_10130 ENOG4107R5W Monooxygenase MAIC_10140 ENOG4105F95 Monooxygenase MAIC_10150 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F MAIC_10170 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MAIC_10220 ENOG4108KPJ rna polymerase sigma factor MAIC_10250 ENOG4105F8V Hydrolase, tatD family MAIC_10260 ENOG4106839 domain protein MAIC_10280 ENOG4107QPV Serine Threonine protein kinase MAIC_10290 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) MAIC_10300 ENOG4107RCI amp-dependent synthetase and ligase MAIC_10350 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) MAIC_10360 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) MAIC_10390 ENOG4105K89 arsenate reductase MAIC_10440 ENOG4105DXN mazG family MAIC_10450 ENOG4105DBE peroxidase MAIC_10460 ENOG410650H (LipO)protein MAIC_10470 ENOG4105EKT )-iron permease MAIC_10560 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) MAIC_10570 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) MAIC_10580 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) MAIC_10600 ENOG4105C1B dTDP-glucose 4-6-dehydratase MAIC_10640 ENOG4105CUX Signal transduction histidine kinase MAIC_10650 ENOG4108JU3 Alkyl hydroperoxide reductase MAIC_10660 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) MAIC_10670 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits MAIC_10680 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) MAIC_10690 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) MAIC_10700 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) MAIC_10800 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin MAIC_10830 ENOG4105EC2 ftsk spoIIIe MAIC_10870 ENOG4107RR1 TRANSCRIPTIONal MAIC_10880 ENOG4105C26 Dehydrogenase MAIC_10920 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) MAIC_10930 ENOG4108UJD 30S ribosomal protein S9 MAIC_10950 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) MAIC_10980 ENOG4105DYW oxidoreductase MAIC_11000 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) MAIC_11050 ENOG4105CVK Glutamate decarboxylase MAIC_11060 ENOG4107QN2 dihydrolipoyl dehydrogenase MAIC_11090 ENOG4108KN0 Choline kinase MAIC_11130 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 MAIC_11160 ENOG41080E2 ribosomal-protein-alanine acetyltransferase MAIC_11170 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) MAIC_11190 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) MAIC_11330 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) MAIC_11380 ENOG4108VT4 MAIC_11400 ENOG4107QVP Dehydrogenase MAIC_11450 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) MAIC_11550 ENOG4105GCF PGAM MAIC_11610 ENOG4105EEM helicase MAIC_11620 ENOG4105C0B DNA polymerase III (alpha subunit) MAIC_11660 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) MAIC_11690 ENOG4105BZU Histidine kinase MAIC_11700 ENOG4105GWZ Roadblock lc7 family protein MAIC_11730 ENOG4107Z6C Pentapeptide repeat-containing protein MAIC_11800 ENOG4105IDI abc transporter atp-binding protein MAIC_11810 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MAIC_11840 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) MAIC_11860 ENOG4105BZU Histidine kinase MAIC_11870 ENOG4105BZU Histidine kinase MAIC_11900 ENOG4108IQK o-acetylhomoserine MAIC_11910 ENOG4105E9K Isocitrate dehydrogenase MAIC_12010 ENOG4107H3J ribonuclease MAIC_12080 ENOG4105DZ1 carboxypeptidase MAIC_12100 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MAIC_12130 ENOG4105U5Y Transcriptional regulator MAIC_12150 ENOG4105E5Q amino acid AbC transporter MAIC_12170 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) MAIC_12180 ENOG4105XPP Protein of unknown function (DUF1275) MAIC_12200 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) MAIC_12210 ENOG4105X7H acyl-CoA dehydrogenase MAIC_12230 ENOG410900P UPF0336 protein MAIC_12270 ENOG4105J5T Amp-dependent synthetase and ligase MAIC_12280 ENOG4106R7G Glycoside hydrolase family 5 MAIC_12290 ENOG4105E33 succinate dehydrogenase MAIC_12350 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) MAIC_12440 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain MAIC_12460 ENOG4108KK1 membrane protein AbrB duplication MAIC_12490 ENOG4107RM1 amidohydrolase MAIC_12580 ENOG4107QRT dEAD DEAH box helicase MAIC_12600 ENOG4107SM8 Adenylate Guanylate cyclase MAIC_12640 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase MAIC_12660 ENOG4105CIR epoxide hydrolase MAIC_12690 ENOG4105C26 Dehydrogenase MAIC_12770 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) MAIC_12840 ENOG4108JIK carboxylase MAIC_12890 ENOG4105D8K carboxyl transferase MAIC_12920 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit MAIC_12930 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) MAIC_12950 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase MAIC_12980 ENOG4107TB5 TRANSCRIPTIONal MAIC_13050 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) MAIC_13080 ENOG4107QKV phosphomannomutase MAIC_13100 ENOG4105EIP mannose-6-phosphate isomerase MAIC_13130 ENOG4105CUB amino acid MAIC_13140 ENOG4105EEF Alkane 1-monooxygenase MAIC_13150 ENOG41084UD rubredoxin MAIC_13160 ENOG4105VCQ rubredoxin MAIC_13220 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MAIC_13340 ENOG4105D74 hydrolase MAIC_13360 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea MAIC_13370 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving MAIC_13400 ENOG4105CSR polyphosphate kinase 2 MAIC_13440 ENOG4105CV8 reductase MAIC_13450 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) MAIC_13460 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase MAIC_13470 ENOG4108RAV Conserved protein MAIC_13490 ENOG4105BZU Histidine kinase MAIC_13500 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr MAIC_13510 ENOG4108Z66 YbaK ebsC protein MAIC_13520 ENOG4105EMN RNA polymerase sigma factor MAIC_13530 ENOG4105WMN AntiSigma factor MAIC_13540 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit MAIC_13570 ENOG4105CBD Diacylglycerol kinase MAIC_13640 ENOG4108ZM9 phosphoglycerate mutase MAIC_13670 ENOG4105C1J atp-dependent rna helicase MAIC_13760 ENOG4108YIQ Alpha beta hydrolase MAIC_13800 ENOG4107SVH Potassium channel protein MAIC_13880 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) MAIC_13920 ENOG41063PX domain protein MAIC_13940 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) MAIC_13970 ENOG4106F59 XRE family Transcriptional regulator MAIC_13980 ENOG4105XUP Phage derived protein Gp49-like (DUF891) MAIC_13990 ENOG4105VTR Integrase MAIC_14290 ENOG4107RSM transcriptional regulator MAIC_14300 ENOG4105D94 Major Facilitator Superfamily MAIC_14460 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) MAIC_14480 ENOG4107RCI amp-dependent synthetase and ligase MAIC_14490 ENOG4107R13 MMPL domain protein MAIC_14510 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) MAIC_14520 ENOG4105JZI cytochrome P450 MAIC_14530 ENOG4107TXC Transcriptional regulator MAIC_14610 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase MAIC_14700 ENOG4105E39 Enoyl-CoA hydratase MAIC_14710 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MAIC_14740 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MAIC_14750 ENOG4105DF2 NADH dehydrogenase subunit j MAIC_14760 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MAIC_14770 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) MAIC_14780 ENOG4108IEH NADH dehydrogenase subunit g MAIC_14820 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain MAIC_14830 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MAIC_14900 ENOG4105C1G acyl-Coa dehydrogenase MAIC_14920 ENOG4108NUI synthase MAIC_14940 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase MAIC_14950 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F MAIC_15020 ENOG41076PI Short-chain dehydrogenase reductase Sdr MAIC_15040 ENOG4105C26 Dehydrogenase MAIC_15080 ENOG41076PI Short-chain dehydrogenase reductase Sdr MAIC_15110 ENOG4106A3M Cytochrome p-450 MAIC_15120 ENOG4105C26 Dehydrogenase MAIC_15140 ENOG4107QY8 reductase MAIC_15160 ENOG4107S5I aldo keto reductase MAIC_15170 ENOG4105C1G acyl-Coa dehydrogenase MAIC_15180 ENOG4105C1G acyl-Coa dehydrogenase MAIC_15190 ENOG4107TK4 histidinol-phosphate phosphatase MAIC_15270 ENOG4105D8X mechanosensitive ion channel MAIC_15290 ENOG4105CAK Cell division ATP-binding protein ftsE MAIC_15300 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) MAIC_15310 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) MAIC_15380 ENOG4107ZVI PhiRv2 prophage protein MAIC_15550 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) MAIC_15850 ENOG4105BZU Histidine kinase MAIC_16120 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) MAIC_16140 ENOG4105DNP FAD linked oxidase domain protein MAIC_16190 ENOG4105MP9 class II Aldolase MAIC_16200 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_16320 ENOG4105CT3 Monooxygenase MAIC_16330 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) MAIC_16360 ENOG41088PD hydrolase MAIC_16410 ENOG4105ERH Fumarylacetoacetate hydrolase MAIC_16420 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase MAIC_16500 ENOG4105C1G acyl-Coa dehydrogenase MAIC_16510 ENOG4105CC9 acyl-Coa dehydrogenase MAIC_16540 ENOG4105D22 carbon starvation protein MAIC_16600 ENOG4105D2B acyl-CoA dehydrogenase MAIC_16680 ENOG4108KEZ Dehydrogenase MAIC_16720 ENOG4108YYH Nadph-dependent fmn reductase MAIC_16810 ENOG4106NZI LysR family Transcriptional regulator MAIC_16830 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b MAIC_16860 ENOG4105EWI Short-chain dehydrogenase reductase Sdr MAIC_16900 ENOG4105EJ2 Transcriptional regulator MAIC_16910 ENOG4107RN6 Monooxygenase MAIC_16940 ENOG4105D3W isochorismatase MAIC_16950 ENOG4108J2P Alpha beta hydrolase fold MAIC_16990 ENOG4105H9W Short-chain dehydrogenase reductase Sdr MAIC_17060 ENOG4105DQ4 alcohol dehydrogenase MAIC_17110 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MAIC_17130 ENOG4108VW9 Membrane MAIC_17140 ENOG4105DKW ABC transporter MAIC_17200 ENOG4108V0V Pyrrolo-quinoline quinone MAIC_17210 ENOG4105EVB acetyltransferase MAIC_17250 ENOG4108KQJ Type 11 methyltransferase MAIC_17270 ENOG4105C10 Electron transfer flavoprotein MAIC_17310 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) MAIC_17400 ENOG4105V9F hemagglutinin MAIC_17460 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MAIC_17530 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) MAIC_17540 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) MAIC_17560 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) MAIC_17620 ENOG4105E3S small subunit MAIC_17630 ENOG4105DPX Hydrogenase, large subunit MAIC_17720 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) MAIC_17750 ENOG4105CQS hydrogenase expression formation protein HypD MAIC_17830 ENOG4105CMT Dihydroxyacetone kinase MAIC_17840 ENOG4107YVI ribose 5-phosphate isomerase MAIC_17850 ENOG4108RZE Tetr family transcriptional regulator MAIC_17910 ENOG4108ZP8 Acetolactate synthase small subunit MAIC_17950 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) MAIC_17960 ENOG4105E5T Major Facilitator Superfamily MAIC_17970 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase MAIC_17980 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) MAIC_18010 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) MAIC_18050 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) MAIC_18080 ENOG4105C28 cystathionine MAIC_18090 ENOG4105CPF Cell wall formation (By similarity) MAIC_18150 ENOG4105DP4 dak2 domain fusion protein ylov MAIC_18180 ENOG41081JD Transcriptional regulator MAIC_18190 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) MAIC_18200 ENOG4105CV8 reductase MAIC_18250 ENOG4106H78 methyltransferase MAIC_18260 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) MAIC_18300 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) MAIC_18310 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) MAIC_18330 ENOG4108375 Acylphosphatase (EC 3.6.1.7) MAIC_18360 ENOG4107SGM protein serine threonine phosphatase MAIC_18380 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) MAIC_18420 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) MAIC_18430 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY MAIC_18460 ENOG4105DZ1 carboxypeptidase MAIC_18480 ENOG4105DZ1 carboxypeptidase MAIC_18490 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) MAIC_18510 ENOG4105K5M 30s ribosomal protein S16 MAIC_18530 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) MAIC_18540 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) MAIC_18570 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) MAIC_18620 ENOG4105F27 Major Facilitator MAIC_18730 ENOG4105XTG Pfam:DUF156 MAIC_18740 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MAIC_18750 ENOG4105CNG UPF0061 protein MAIC_18770 ENOG4105CE9 30S ribosomal protein S2 MAIC_18790 ENOG4105DV0 amidase (EC 3.5.1.4 MAIC_18820 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) MAIC_18910 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs MAIC_18930 ENOG4105CVP deoxyribo-dipyrimidine photolyase MAIC_18970 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) MAIC_18980 ENOG4105DZP Membrane-associated zinc metalloprotease MAIC_18990 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) MAIC_19030 ENOG4105EA8 2-Nitropropane dioxygenase MAIC_19110 ENOG4105CAQ asparagine synthetase MAIC_19140 ENOG4108Z86 Glutamine amidotransferase MAIC_19160 ENOG4105CHR reductase MAIC_19170 ENOG41073TP transcriptional regulator MAIC_19180 ENOG4105CPQ Dehydrogenase MAIC_19230 ENOG4105EN6 Membrane MAIC_19240 ENOG4105CH2 amidohydrolase MAIC_19330 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) MAIC_19360 ENOG4108JJB ABC transporter MAIC_19390 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) MAIC_19410 ENOG4105E98 transcriptional regulator DeoR family MAIC_19490 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) MAIC_19590 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) MAIC_19620 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) MAIC_19640 ENOG4105SFS phosphoesterase RecJ domain protein MAIC_19660 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) MAIC_19670 ENOG4108NNZ chitinase MAIC_19680 ENOG4105E39 Enoyl-CoA hydratase MAIC_19700 ENOG41067SE Tetr family transcriptional regulator MAIC_19760 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) MAIC_19810 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) MAIC_19840 ENOG4107QWG 2-Nitropropane dioxygenase MAIC_19870 ENOG4105DCF alanine dehydrogenase MAIC_20000 ENOG4105EAH synthase MAIC_20080 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) MAIC_20090 ENOG4105T0Z Conserved Protein MAIC_20100 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_20110 ENOG4105BZU Histidine kinase MAIC_20130 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) MAIC_20170 ENOG4105E3J oxidoreductase MAIC_20250 ENOG4108I62 cina-like protein MAIC_20260 ENOG4105WBV Transcriptional regulator MAIC_20290 ENOG4105MXB limonene-12-epoxide hydrolase MAIC_20330 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) MAIC_20370 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MAIC_20400 ENOG4105DRP amino acid AbC transporter MAIC_20410 ENOG4108Q1T ABC transporter MAIC_20420 ENOG4107UBR Extracellular solute-binding protein family 3 MAIC_20430 ENOG4105CDA abc transporter atp-binding protein MAIC_20440 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) MAIC_20460 ENOG4105C99 atpase involved in dna repair MAIC_20470 ENOG4105PP6 Membrane MAIC_20490 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) MAIC_20500 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) MAIC_20510 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) MAIC_20530 ENOG4108J2R molybdopterin oxidoreductase MAIC_20540 ENOG4105C1G acyl-Coa dehydrogenase MAIC_20560 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) MAIC_20740 ENOG4107QK9 Beta-lactamase MAIC_20810 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) MAIC_20880 ENOG4107VEG TrkA-N domain protein MAIC_20890 ENOG4105C0X amino acid MAIC_20900 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) MAIC_20910 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) MAIC_20930 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) MAIC_20950 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) MAIC_20970 ENOG4107JTW chlorite dismutase MAIC_20980 ENOG4105BZU Histidine kinase MAIC_20990 ENOG4105BZU Histidine kinase MAIC_21000 ENOG4105BZU Histidine kinase MAIC_21010 ENOG4105E0X reductase MAIC_21020 ENOG4108P2G integral membrane protein MAIC_21170 ENOG4105ETX regulatoR MAIC_21180 ENOG4105BZU Histidine kinase MAIC_21220 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MAIC_21240 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic MAIC_21380 ENOG4107SHJ sulfite reductase subunit b MAIC_21410 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) MAIC_21490 ENOG4108IQE Amp-dependent synthetase and ligase MAIC_21510 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) MAIC_21680 ENOG4105WN5 stage II sporulation protein MAIC_21720 ENOG4105CHR reductase MAIC_21770 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) MAIC_21840 ENOG4105PMW Domain of unknown function (DUF1990) MAIC_21870 ENOG4105C22 threonyL-tRNA synthetase MAIC_21900 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase MAIC_21910 ENOG4105E2K Glycosyl transferase (Group 1 MAIC_21940 ENOG4105C29 acyl-CoA thioesterase MAIC_21950 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) MAIC_22000 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase MAIC_22030 ENOG4106A3M Cytochrome p-450 MAIC_22040 ENOG4105C01 Dihydroxy-acid dehydratase MAIC_22080 ENOG4108RFG Tetr family transcriptional regulator MAIC_22130 ENOG4105J4Q Transcriptional regulator MAIC_22220 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) MAIC_22240 ENOG4105BZU Histidine kinase MAIC_22250 ENOG4105E4E Thioester reductase domain-containing protein MAIC_22280 ENOG4105C26 Dehydrogenase MAIC_22290 ENOG4108JPW Aminotransferase MAIC_22330 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) MAIC_22340 ENOG4108NY6 Extracellular solute-binding protein, family 5 MAIC_22350 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) MAIC_22360 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) MAIC_22390 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) MAIC_22420 ENOG4105CUT histidyl-tRNA synthetase MAIC_22460 ENOG4107VGR Catalase MAIC_22470 ENOG4108IV0 ABC, transporter MAIC_22480 ENOG4105C0Z ABC transporter MAIC_22500 ENOG4105C32 Amino acid ABC transporter (Permease) MAIC_22510 ENOG41083Z3 extracellular ligand-binding receptor MAIC_22590 ENOG4105D2B acyl-CoA dehydrogenase MAIC_22650 ENOG4105EBR Carboxylesterase MAIC_22670 ENOG4105C9M aspartyl-trna synthetase MAIC_22710 ENOG4105CHU acetyl-coa acetyltransferase MAIC_22720 ENOG4105KVH Transcriptional regulator MAIC_22830 ENOG4105CMR udp-glucose 4-epimerase MAIC_22890 ENOG4105C1G acyl-Coa dehydrogenase MAIC_22900 ENOG4105CHR reductase MAIC_22920 ENOG4105DYW oxidoreductase MAIC_23010 ENOG4107ZED Uncharacterised protein family UPF0047 MAIC_23020 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) MAIC_23030 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) MAIC_23050 ENOG4105E2X shikimate dehydrogenase MAIC_23070 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) MAIC_23130 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MAIC_23170 ENOG4105D49 3-dehydroquinate synthase MAIC_23190 ENOG4105CY0 Metallo-Beta-Lactamase MAIC_23210 ENOG4105DC7 peptidase M24 MAIC_23220 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) MAIC_23250 ENOG4108KC1 acyl-Coa dehydrogenase MAIC_23260 ENOG4106P19 photosystem i assembly btpa MAIC_23270 ENOG4105E98 transcriptional regulator DeoR family MAIC_23330 ENOG4108IJ9 (ABC) transporter MAIC_23340 ENOG4105ECY inositol monophosphatase MAIC_23390 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) MAIC_23400 ENOG4105CXT aspartate transcarbamylase MAIC_23430 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain MAIC_23450 ENOG4105SKN orotidine 5''-phosphate decarboxylase MAIC_23490 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) MAIC_23530 ENOG4105F6U Short-chain dehydrogenase reductase Sdr MAIC_23600 ENOG4108V0P LemA family MAIC_23610 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) MAIC_23650 ENOG4107R7Y intracellular protease Pfpi family MAIC_23690 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MAIC_23700 ENOG4105C3U ABC transporter MAIC_23720 ENOG4107S4Y M20 DapE family protein YgeY MAIC_23740 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase MAIC_23750 ENOG4105CMG Carbohydrate kinase MAIC_23760 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) MAIC_23770 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) MAIC_23780 ENOG4107UWP Major facilitator superfamily MFS_1 MAIC_23830 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) MAIC_23870 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) MAIC_23880 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) MAIC_23900 ENOG4105CIE May be required for sporulation (By similarity) MAIC_23930 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase MAIC_23940 ENOG4105BZA Phosphoglycerate kinase MAIC_23950 ENOG4105CP7 Triose-phosphate isomerase MAIC_24000 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) MAIC_24070 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) MAIC_24090 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) MAIC_24100 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein MAIC_24150 ENOG4107JC6 Membrane MAIC_24190 ENOG4105C3K feS assembly ATPase SufC MAIC_24210 ENOG4108UNV SUF system FeS assembly protein, NifU family MAIC_24220 ENOG4105VG1 fes assembly suf system protein MAIC_24260 ENOG41080RH Thioredoxin MAIC_24280 ENOG4105C5H ABC transporter MAIC_24310 ENOG4108Q5F Tetr family transcriptional regulator MAIC_24320 ENOG4107QM5 aconitate hydratase MAIC_24340 ENOG4105ZXU NLP P60 protein MAIC_24360 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MAIC_24380 ENOG4107QVM von Willebrand factor, type A MAIC_24390 ENOG4105CHR reductase MAIC_24400 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH MAIC_24410 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) MAIC_24540 ENOG4107S1E Beta-lactamase MAIC_24640 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) MAIC_24660 ENOG4105HDK L-asparaginase MAIC_24670 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) MAIC_24720 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) MAIC_24810 ENOG4105C57 major facilitator superfamily MAIC_24830 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) MAIC_24840 ENOG4105DQQ Major facilitator superfamily MFS_1 MAIC_24850 ENOG4107QZF nitrite reductase NADPH large subunit MAIC_24950 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) MAIC_24990 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) MAIC_25000 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) MAIC_25050 ENOG4107S3R L-aspartate oxidase MAIC_25080 ENOG410829K Lysine exporter protein (Lyse ygga) MAIC_25090 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) MAIC_25100 ENOG4105CIH Imidazole acetol-phosphate transaminase MAIC_25110 ENOG4105ECC imidazole-glycerol-phosphate dehydratase MAIC_25120 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) MAIC_25130 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase MAIC_25140 ENOG4108MWI inositol mono-phosphatase MAIC_25150 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) MAIC_25160 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase MAIC_25170 ENOG4105DNP FAD linked oxidase domain protein MAIC_25180 ENOG4105DKW ABC transporter MAIC_25220 ENOG4105DK0 Indole-3-glycerol phosphate synthase MAIC_25270 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) MAIC_25300 ENOG4108JGH Tetr family transcriptional regulator MAIC_25350 ENOG4105CHR reductase MAIC_25370 ENOG41082JN Transcriptional regulator MAIC_25400 ENOG41082BM Transcriptional regulator, arsr family MAIC_25530 ENOG4105E5F proteasome MAIC_25550 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) MAIC_25560 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) MAIC_25600 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) MAIC_25620 ENOG4107TMB Transcriptional regulator MAIC_25680 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase MAIC_25710 ENOG4108RG3 short-chain dehydrogenase reductase MAIC_25810 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MAIC_25850 ENOG4105CTK cobaltochelatase, cobn subunit MAIC_25890 ENOG4105CPN adenine deaminase MAIC_25910 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) MAIC_25920 ENOG4105Q70 MAIC_25950 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component MAIC_25980 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) MAIC_25990 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein MAIC_26000 ENOG41082SX arsR family transcriptional regulator MAIC_26040 ENOG4105EBR Carboxylesterase MAIC_26100 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family MAIC_26110 ENOG4105C6Z Gluconate MAIC_26190 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) MAIC_26220 ENOG4108RWI nicotinamidase MAIC_26250 ENOG4108SVW integral membrane protein MAIC_26260 ENOG4105DHT Metal Dependent Phosphohydrolase MAIC_26290 ENOG4105D38 putrescine abc transporter MAIC_26300 ENOG4105F38 ABC transporter, permease MAIC_26330 ENOG4105C1G acyl-Coa dehydrogenase MAIC_26360 ENOG4105CY3 ABC transporter, permease MAIC_26450 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein MAIC_26470 ENOG4105DRS transport system, permease MAIC_26480 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component MAIC_26500 ENOG4105F8D glycoside hydrolase family 4 MAIC_26530 ENOG4105E70 isomerase MAIC_26540 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of MAIC_26550 ENOG4105E98 transcriptional regulator DeoR family MAIC_26590 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein MAIC_26690 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_26700 ENOG4105C1G acyl-Coa dehydrogenase MAIC_26720 ENOG4105H9W Short-chain dehydrogenase reductase Sdr MAIC_26740 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MAIC_26790 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase MAIC_26820 ENOG4107S2E monooxygenase MAIC_26840 ENOG41076PI Short-chain dehydrogenase reductase Sdr MAIC_26860 ENOG4105DYW oxidoreductase MAIC_26930 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase MAIC_26950 ENOG4107S2E monooxygenase MAIC_26970 ENOG4105BZU Histidine kinase MAIC_26980 ENOG4105D64 Mechanosensitive ion channel MAIC_26990 ENOG4105D5U fad dependent oxidoreductase MAIC_27040 ENOG4107RCC Major Facilitator Superfamily MAIC_27270 ENOG4105CHR reductase MAIC_27320 ENOG4105D3Q Sugar transferase MAIC_27350 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) MAIC_27390 ENOG4108WKN secreted protein MAIC_27410 ENOG4105CHR reductase MAIC_27420 ENOG4105BZU Histidine kinase MAIC_27430 ENOG4105KIR Thiol-disulfide oxidoreductase dcc MAIC_27450 ENOG4105CHU acetyl-coa acetyltransferase MAIC_27460 ENOG4105BZU Histidine kinase MAIC_27500 ENOG4107R13 MMPL domain protein MAIC_27590 ENOG4105C0H protease MAIC_27610 ENOG4108V1T peptidylprolyl cis-trans isomerase MAIC_27780 ENOG4105F87 Dehydratase MAIC_27820 ENOG4105ZXU NLP P60 protein MAIC_27860 ENOG4105C26 Dehydrogenase MAIC_27870 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MAIC_27920 ENOG4105CPQ Dehydrogenase MAIC_27970 ENOG4107TCW O-succinylbenzoate synthase MAIC_28010 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) MAIC_28080 ENOG4108VCA G U mismatch-specific DNA glycosylase MAIC_28090 ENOG4107S5I aldo keto reductase MAIC_28150 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) MAIC_28160 ENOG4105X1Q TOBE domain protein MAIC_28190 ENOG4105BZU Histidine kinase MAIC_28200 ENOG4107XFJ UPF0246 protein MAIC_28400 ENOG4105CEV competence damage-inducible protein MAIC_28440 ENOG4105PP6 Membrane MAIC_28570 ENOG4105CHR reductase MAIC_28590 ENOG4105Q56 cytochrome P450 MAIC_28670 ENOG4105FF0 ErfK YbiS YcfS YnhG MAIC_28750 ENOG4105WWF Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) MAIC_28770 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MAIC_28830 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) MAIC_28880 ENOG4108MJN Glycosyl Transferase MAIC_28900 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) MAIC_28920 ENOG4105CHR reductase MAIC_28940 ENOG4105MXB limonene-12-epoxide hydrolase MAIC_28990 ENOG4105C5F glutamine synthetase MAIC_29020 ENOG4108UQY Iron-storage protein MAIC_29030 ENOG4108UKI Enoyl-CoA hydratase MAIC_29180 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) MAIC_29200 ENOG4105DYW oxidoreductase MAIC_29250 ENOG4105CHU acetyl-coa acetyltransferase MAIC_29300 ENOG4107QRI Phosphoketolase MAIC_29350 ENOG4105Y3U Transglycosylase-associated protein MAIC_29400 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MAIC_29430 ENOG4108TAG Histidine kinase MAIC_29440 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) MAIC_29450 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) MAIC_29470 ENOG4105CQM Urea amidohydrolase subunit alpha MAIC_29540 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) MAIC_29560 ENOG4105C37 (CBS) domain MAIC_29570 ENOG4107UAX integral membrane protein MAIC_29600 ENOG4107QP3 malate synthase g MAIC_29630 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor MAIC_29680 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) MAIC_29760 ENOG4107EFR Flavocytochrome c MAIC_29810 ENOG4105CJP fad dependent oxidoreductase MAIC_29820 ENOG4105CKD glutathione-regulated potassium-efflux system protein MAIC_29850 ENOG4105EBR Carboxylesterase MAIC_29860 ENOG410814C multidrug resistance protein MAIC_29870 ENOG410814C multidrug resistance protein MAIC_29970 ENOG410633P Hydantoin racemase MAIC_30030 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MAIC_30050 ENOG4108RZE Tetr family transcriptional regulator MAIC_30070 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein MAIC_30150 ENOG410834F Transcriptional regulator MAIC_30200 ENOG4105CQB FAD linked oxidase domain protein MAIC_30210 ENOG4105DIA mandelate racemase muconate lactonizing MAIC_30220 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) MAIC_30260 ENOG4108W6C Dehydrogenase MAIC_30300 ENOG4107VFM Dehydrogenase MAIC_30320 ENOG4105CSH Transporter MAIC_30330 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) MAIC_30350 ENOG4105CFN oxalyl-CoA decarboxylase MAIC_30360 ENOG4105D2B acyl-CoA dehydrogenase MAIC_30370 ENOG4105CC9 acyl-Coa dehydrogenase MAIC_30380 ENOG4105C1G acyl-Coa dehydrogenase MAIC_30390 ENOG4105CC9 acyl-Coa dehydrogenase MAIC_30400 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F MAIC_30410 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr MAIC_30420 ENOG4107R5W Monooxygenase MAIC_30470 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_30490 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_30520 ENOG4105CUB amino acid MAIC_30620 ENOG4105C7N Xanthine uracil vitamin C permease MAIC_30630 ENOG41080U6 GntR family transcriptional regulator MAIC_30670 ENOG4105CY5 solute-binding protein MAIC_30690 ENOG4108MP3 ABC transporter, permease MAIC_30820 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) MAIC_30870 ENOG4105DNP FAD linked oxidase domain protein MAIC_30920 ENOG4105MKU Transcriptional regulator MAIC_30970 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) MAIC_31030 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) MAIC_31040 ENOG4105CAT Cytidine monophosphate kinase MAIC_31060 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) MAIC_31070 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) MAIC_31110 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) MAIC_31190 ENOG4105DSU hydrolase MAIC_31230 ENOG4105CIG ABC transporter MAIC_31260 ENOG4105W49 UPF0434 protein MAIC_31290 ENOG4105C5H ABC transporter MAIC_31340 ENOG4105CH7 arginosuccinase MAIC_31350 ENOG4105CDH Citrulline--aspartate ligase MAIC_31370 ENOG4105DBV ornithine carbamoyltransferase MAIC_31380 ENOG4105C8Y Acetylornithine aminotransferase MAIC_31390 ENOG4105CAS nag kinase MAIC_31400 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) MAIC_31410 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase MAIC_31420 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) MAIC_31430 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) MAIC_31440 ENOG4105CBC glutamate synthase MAIC_31460 ENOG4108Z4U Ferredoxin MAIC_31580 ENOG4105C1G acyl-Coa dehydrogenase MAIC_31600 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding MAIC_31610 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit MAIC_31620 ENOG4105C7W Xanthine dehydrogenase MAIC_31650 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) MAIC_31660 ENOG41084BS 50S ribosomal protein L35 MAIC_31690 ENOG4105CRK lysyL-tRNA synthetase MAIC_31720 ENOG4107GJV short-chain dehydrogenase reductase MAIC_31740 ENOG4105C5X domain protein MAIC_31780 ENOG4105D7N magnesium and cobalt transport protein CorA MAIC_31860 ENOG4105KT7 mgtC SapB transporter MAIC_31930 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) MAIC_31950 ENOG4105EN6 Membrane MAIC_32000 ENOG41063C6 UPF0235 protein MAIC_32040 ENOG4108IV0 ABC, transporter MAIC_32050 ENOG4105C0Z ABC transporter MAIC_32060 ENOG4105CF8 branched-chain amino acid ABC transporter, permease MAIC_32070 ENOG4105C32 Amino acid ABC transporter (Permease) MAIC_32120 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase MAIC_32170 ENOG4106PMH Extracellular solute-binding protein family 3 MAIC_32200 ENOG4105C4M (Ubiquinol oxidase) subunit I MAIC_32210 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii MAIC_32220 ENOG4108JJ9 ABC, transporter MAIC_32230 ENOG4108JJ8 (ABC) transporter MAIC_32260 ENOG4105C29 acyl-CoA thioesterase MAIC_32290 ENOG4105CBC glutamate synthase MAIC_32330 ENOG4107QN2 dihydrolipoyl dehydrogenase MAIC_32350 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) MAIC_32400 ENOG4108J5G 6-phosphogluconate dehydrogenase MAIC_32470 ENOG4105CC9 acyl-Coa dehydrogenase MAIC_32480 ENOG4105C1G acyl-Coa dehydrogenase MAIC_32490 ENOG4105C8N cysteinyl-tRNA synthetase MAIC_32500 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo MAIC_32580 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) MAIC_32620 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) MAIC_32660 ENOG4105CPT Alpha beta hydrolase MAIC_32710 ENOG4105WH9 RNA polymerase MAIC_32770 ENOG4105SHT UspA domain-containing protein MAIC_32800 ENOG4105JN3 extra-cytoplasmic solute receptor family protein MAIC_32810 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism MAIC_32820 ENOG4108V9W transcriptional regulatory protein MAIC_32830 ENOG4107SCA Formamidase (EC 3.5.1.49) MAIC_32840 ENOG4105KME endoribonuclease L-psp MAIC_32870 ENOG41061TZ Short-chain dehydrogenase reductase Sdr MAIC_32880 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) MAIC_32900 ENOG4105CA9 Pyruvate kinase MAIC_32960 ENOG4105DFA alanine racemase domain protein MAIC_33030 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) MAIC_33040 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) MAIC_33070 ENOG4105CJN penicillin-binding protein MAIC_33090 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) MAIC_33130 ENOG4105R14 (LipO)protein MAIC_33150 ENOG41090CE integral membrane protein MAIC_33160 ENOG4105KYH transcriptional regulatory protein MAIC_33180 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase MAIC_33210 ENOG4108VJY integral membrane protein MAIC_33360 ENOG4105CCU oxidase (Subunit III) MAIC_33460 ENOG4107T4Z adenosine kinase MAIC_33520 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) MAIC_33550 ENOG4105CM2 brancheD-chain amino acid aminotransferase MAIC_33680 ENOG4105C5F glutamine synthetase MAIC_33700 ENOG4108V9Q carbonic anhydrase MAIC_33720 ENOG4105EVH UPF0753 protein MAIC_33730 ENOG4108TWJ NADH dehydrogenase subunit 5 MAIC_33770 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) MAIC_33780 ENOG4105C5F glutamine synthetase MAIC_33830 ENOG4108UKI Enoyl-CoA hydratase MAIC_33970 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) MAIC_34050 ENOG4105EA8 2-Nitropropane dioxygenase MAIC_34060 ENOG4105DJ2 Major Facilitator Superfamily MAIC_34070 ENOG4105C6F GntR Family Transcriptional Regulator MAIC_34130 ENOG4105C5X domain protein MAIC_34170 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) MAIC_34190 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase MAIC_34200 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) MAIC_34210 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) MAIC_34240 ENOG4105CF7 AraC family transcriptional regulator MAIC_34250 ENOG4105CPC Aldo Keto reductase MAIC_34260 ENOG4105C85 amino acid MAIC_34490 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) MAIC_34540 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MAIC_34550 ENOG4108JQ6 ABC transporter MAIC_34740 ENOG4107T8P acyl-Coa dehydrogenase MAIC_34750 ENOG4105FBW Monooxygenase MAIC_34770 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component MAIC_34780 ENOG4106FTQ Taurine ABC transporter, periplasmic MAIC_35010 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component MAIC_35020 ENOG4105DRS transport system, permease MAIC_35070 ENOG4105DXB Major Facilitator superfamily MAIC_35080 ENOG4105FFC UPF0187 protein MAIC_35100 ENOG4105C1G acyl-Coa dehydrogenase MAIC_35120 ENOG4105CCU oxidase (Subunit III) MAIC_35160 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) MAIC_35190 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) MAIC_35270 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) MAIC_35290 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) MAIC_35330 ENOG4105WH1 Two component transcriptional regulator luxr family MAIC_35350 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) MAIC_35360 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) MAIC_35380 ENOG4105BZU Histidine kinase MAIC_35390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MAIC_35400 ENOG4105CHH sulfate transporter MAIC_35470 ENOG4105ECW sulfate abc transporter MAIC_35480 ENOG4108I5D sulfate abc transporter MAIC_35490 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein MAIC_35510 ENOG4105BZP glycoside hydrolase 15-related MAIC_35530 ENOG4105C2C drug resistance transporter, Bcr CflA MAIC_35580 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) MAIC_35590 ENOG4105CPC Aldo Keto reductase MAIC_35600 ENOG4108IG5 Transcriptional regulator MAIC_35620 ENOG4105CFQ glutamine synthetase MAIC_35630 ENOG4107XDQ Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) MAIC_35710 ENOG4105KQC Competence protein MAIC_35750 ENOG4108TZC MAIC_35770 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) MAIC_35780 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) MAIC_35810 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit MAIC_35820 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) MAIC_35830 ENOG4108RVA ribokinase MAIC_35840 ENOG4105E39 Enoyl-CoA hydratase MAIC_35920 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) MAIC_35930 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control MAIC_35940 ENOG4105K46 50S ribosomal protein l27 MAIC_35960 ENOG4105C03 ribonuclease MAIC_35970 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) MAIC_35990 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase MAIC_36000 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) MAIC_36020 ENOG4105EG6 Saccharopine dehydrogenase MAIC_36030 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein MAIC_36070 ENOG41080AZ Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) MAIC_36080 ENOG4105DQU oxidoreductase, subunit beta MAIC_36090 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein MAIC_36100 ENOG4108RVA ribokinase MAIC_36110 ENOG4105ETE Transcriptional regulator (LacI family MAIC_36130 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) MAIC_36170 ENOG4105C2J ABC transporter MAIC_36180 ENOG41062B0 ABC transporter, permease MAIC_36260 ENOG4105DH8 myo-inositol catabolism MAIC_36270 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) MAIC_36290 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) MAIC_36300 ENOG4105CHR reductase MAIC_36320 ENOG4108VCT Sulfite exporter TauE/SafE MAIC_36330 ENOG41080RH Thioredoxin MAIC_36350 ENOG4107QPB Beta-lactamase domain protein MAIC_36360 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) MAIC_36440 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) MAIC_36450 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) MAIC_36460 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation MAIC_36590 ENOG4108YZG isomerase MAIC_36610 ENOG4107SET aldo keto reductase MAIC_36650 ENOG4105MC2 DSBA oxidoreductase MAIC_36680 ENOG4109057 MAIC_36720 ENOG4105CG3 alpha amylase, catalytic region MAIC_36760 ENOG4105C7I Dehydrogenase MAIC_36860 ENOG4105DTD Dehydrogenase MAIC_36980 ENOG4108KPJ rna polymerase sigma factor MAIC_37010 ENOG4105C5B carbamate kinase MAIC_37020 ENOG4107REC cytoplasmic protein MAIC_37030 ENOG4107R1Q Membrane protein FdrA MAIC_37040 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) MAIC_37080 ENOG41082BM Transcriptional regulator, arsr family MAIC_37090 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 MAIC_37140 ENOG4105C1G acyl-Coa dehydrogenase MAIC_37160 ENOG4107QX3 carboxylase MAIC_37230 ENOG4105EMU Dehydrogenase MAIC_37240 ENOG4105D7A ATP-binding protein MAIC_37280 ENOG4107UBC ErfK ybiS ycfS ynhG family protein MAIC_37290 ENOG4105D8V Glucose sorbosone dehydrogenase MAIC_37330 ENOG4105C54 Major Facilitator superfamily MAIC_37380 ENOG4105NPE arsR family transcriptional regulator MAIC_37390 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase MAIC_37420 ENOG4108WKN secreted protein MAIC_37430 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MAIC_37440 ENOG4107TYH extracellular solute-binding protein family 1 MAIC_37450 ENOG4105D81 ABC transporter, permease MAIC_37460 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component MAIC_37490 ENOG4105C1G acyl-Coa dehydrogenase MAIC_37560 ENOG4105CHR reductase MAIC_37640 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_37790 ENOG4105F0I Aminotransferase MAIC_37800 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) MAIC_37820 ENOG4106A3M Cytochrome p-450 MAIC_37830 ENOG41076PI Short-chain dehydrogenase reductase Sdr MAIC_37840 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) MAIC_37850 ENOG4108JNI Alpha beta hydrolase MAIC_37900 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein MAIC_37910 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) MAIC_37930 ENOG4108WC5 Alpha Beta Hydrolase Fold protein MAIC_37950 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein MAIC_37970 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_38060 ENOG4105CMR udp-glucose 4-epimerase MAIC_38080 ENOG4105H9W Short-chain dehydrogenase reductase Sdr MAIC_38130 ENOG4105CHU acetyl-coa acetyltransferase MAIC_38290 ENOG4105CY3 ABC transporter, permease MAIC_38320 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F MAIC_38340 ENOG41076PI Short-chain dehydrogenase reductase Sdr MAIC_38380 ENOG4105CC9 acyl-Coa dehydrogenase MAIC_38390 ENOG4105C1G acyl-Coa dehydrogenase MAIC_38450 ENOG4107QIZ NADH dehydrogenase MAIC_38510 ENOG4106A3M Cytochrome p-450 MAIC_38540 ENOG4107Z3H Transcriptional regulator, TetR family MAIC_38550 ENOG4105C1G acyl-Coa dehydrogenase MAIC_38560 ENOG4105CHU acetyl-coa acetyltransferase MAIC_38610 ENOG4105DVW rieske (2Fe-2S) MAIC_38630 ENOG4105CPN adenine deaminase MAIC_38650 ENOG4105CC9 acyl-Coa dehydrogenase MAIC_38660 ENOG4105D2B acyl-CoA dehydrogenase MAIC_38710 ENOG4105CC9 acyl-Coa dehydrogenase MAIC_38720 ENOG4105D2B acyl-CoA dehydrogenase MAIC_38730 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_38750 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F MAIC_38760 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MAIC_38800 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) MAIC_38830 ENOG4105EMU Dehydrogenase MAIC_39000 ENOG4105C6X Major Facilitator MAIC_39020 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) MAIC_39090 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) MAIC_39100 ENOG4107RKP Nicotinate phosphoribosyltransferase MAIC_39150 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) MAIC_39160 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) MAIC_39170 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) MAIC_39200 ENOG4105CHU acetyl-coa acetyltransferase MAIC_39230 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) MAIC_39320 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) MAIC_39330 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) MAIC_39340 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) MAIC_39350 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) MAIC_39360 ENOG4105V1A F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) MAIC_39370 ENOG410679R F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) MAIC_39380 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) MAIC_39400 ENOG4105ESV Glycosyl transferase, family 4 MAIC_39420 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) MAIC_39450 ENOG4105J5T Amp-dependent synthetase and ligase MAIC_39460 ENOG4108RZE Tetr family transcriptional regulator MAIC_39490 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) MAIC_39500 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) MAIC_39510 ENOG4105D6E homoserine dehydrogenase MAIC_39520 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) MAIC_39530 ENOG4105C75 arginyL-tRNA synthetase MAIC_39590 ENOG4107RCI amp-dependent synthetase and ligase MAIC_39690 ENOG4105EXC Acyl-transferase MAIC_39700 ENOG4105EXC Acyl-transferase MAIC_39710 ENOG4105EXC Acyl-transferase MAIC_39780 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) MAIC_39790 ENOG4105C6Y Udp-glucose 6-dehydrogenase MAIC_39860 ENOG4105C0K Gdp-mannose 4,6-dehydratase MAIC_39900 ENOG4105E2K Glycosyl transferase (Group 1 MAIC_40050 ENOG4108JA1 polyketide synthase MAIC_40060 ENOG4107QKG PfaD family MAIC_40100 ENOG4105E5D amino acid MAIC_40150 ENOG4105DMF Dehydrogenase MAIC_40270 ENOG4105C11 sulfate adenylyltransferase), subunit 2 MAIC_40350 ENOG4107T8P acyl-Coa dehydrogenase MAIC_40540 ENOG4105DEN Luciferase family MAIC_40570 ENOG4105CQB FAD linked oxidase domain protein MAIC_40580 ENOG4105CIR epoxide hydrolase MAIC_40600 ENOG4105DVW rieske (2Fe-2S) MAIC_40750 ENOG4105DVW rieske (2Fe-2S) MAIC_40800 ENOG4105CHR reductase MAIC_40810 ENOG41061TZ Short-chain dehydrogenase reductase Sdr MAIC_40860 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) MAIC_41060 ENOG4105CY3 ABC transporter, permease MAIC_41180 ENOG4105C7H Helicase, RecD TraA family MAIC_41190 ENOG4105CQB FAD linked oxidase domain protein MAIC_41230 ENOG4105CNV Aldolase MAIC_41240 ENOG4105CHR reductase MAIC_41250 ENOG4107RN6 Monooxygenase MAIC_41280 ENOG4105CHR reductase MAIC_41300 ENOG4105C2C drug resistance transporter, Bcr CflA MAIC_41320 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 MAIC_41330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MAIC_41340 ENOG4105BZU Histidine kinase MAIC_41420 ENOG4105D7N magnesium and cobalt transport protein CorA MAIC_41510 ENOG4105CI0 Citrate lyase MAIC_41520 ENOG4105CJW magnesium transporter MAIC_41570 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) MAIC_41580 ENOG4105C0H protease MAIC_41590 ENOG4106684 MAIC_41610 ENOG4107ZBN O-methyltransferase MAIC_41630 ENOG4108X07 Tetr family transcriptional regulator MAIC_41640 ENOG4105CIG ABC transporter MAIC_41650 ENOG4105DIM ABC transporter MAIC_41680 ENOG4108IND Tetr family transcriptional regulator MAIC_41720 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) MAIC_41730 ENOG4107QPH glycogen) synthase MAIC_41750 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) MAIC_41770 ENOG4105C3Q Glycosyl transferase, family 2 MAIC_41850 ENOG4107R4C succinyl-diaminopimelate desuccinylase MAIC_41890 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_41940 ENOG41062BK proline dehydrogenase MAIC_41950 ENOG4105C26 Dehydrogenase MAIC_41990 ENOG4108Z4U Ferredoxin MAIC_42030 ENOG4105CPT Alpha beta hydrolase MAIC_42040 ENOG4108J2P Alpha beta hydrolase fold MAIC_42110 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) MAIC_42210 ENOG410719E cytochrome p450 MAIC_42410 ENOG4105C2M dna polymerase I MAIC_42500 ENOG4107VC8 ATP cone domain protein MAIC_42590 ENOG4107TTQ Alpha beta hydrolase fold MAIC_42890 ENOG4105NVB glycoside hydrolase, family 19 MAIC_43140 ENOG4108HRK Histidine kinase MAIC_43150 ENOG4105DY9 regulatoR MAIC_43170 ENOG4107QN1 sodium solute MAIC_43190 ENOG4107QN1 sodium solute MAIC_43220 ENOG410905P Pyridoxamine 5-phosphate MAIC_43290 ENOG4105EA8 2-Nitropropane dioxygenase MAIC_43310 ENOG410846T CoA-transferase family III MAIC_43320 ENOG4108UKI Enoyl-CoA hydratase MAIC_43360 ENOG4105CGD Nad-dependent epimerase dehydratase MAIC_43380 ENOG410906A Beta-Ig-H3 fasciclin MAIC_43400 ENOG4105CHU acetyl-coa acetyltransferase MAIC_43450 ENOG4105DTD Dehydrogenase MAIC_43510 ENOG4105C5I Dehydrogenase MAIC_43520 ENOG4105WH1 Two component transcriptional regulator luxr family MAIC_43600 ENOG4105BZU Histidine kinase MAIC_43620 ENOG4105HS2 Arsenate reductase MAIC_43660 ENOG4105C3G gtp-binding protein MAIC_43700 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) MAIC_43760 ENOG4105ENH Sulfatase MAIC_43780 ENOG4105E6M Sulphatase-modifying factor protein MAIC_43820 ENOG4105CPC Aldo Keto reductase MAIC_43960 ENOG4105EEQ Na H antiporter MAIC_43970 ENOG4107VMI polysaccharide deacetylase MAIC_43980 ENOG4108IAB Phoh family MAIC_44000 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) MAIC_44020 ENOG4105CS9 pantothenic acid kinase MAIC_44070 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) MAIC_44100 ENOG4105C7Z Conserved Protein MAIC_44120 ENOG4105T1M mycothiol conjugate amidase mca MAIC_44180 ENOG4105W8D rdd domain containing protein MAIC_44220 ENOG4105CHU acetyl-coa acetyltransferase MAIC_44320 ENOG4105CIS alcohol dehydrogenase MAIC_44380 ENOG4105DVW rieske (2Fe-2S) MAIC_44390 ENOG4105D38 putrescine abc transporter MAIC_44400 ENOG4105F38 ABC transporter, permease MAIC_44420 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase MAIC_44430 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MAIC_44440 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) MAIC_44480 ENOG4105DDR sarcosine oxidase (Beta subunit) MAIC_44490 ENOG4105C1G acyl-Coa dehydrogenase MAIC_44550 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) MAIC_44560 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) MAIC_44570 ENOG4105W0E 50S ribosomal protein L33 MAIC_44600 ENOG4105NRA 50s ribosomal protein l31 type b MAIC_44740 ENOG4105E5Q amino acid AbC transporter MAIC_44750 ENOG4105CDA abc transporter atp-binding protein MAIC_44760 ENOG4105EV8 ectoine hydroxylase MAIC_44770 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) MAIC_44800 ENOG4108ZHJ Organic hydroperoxide resistance protein MAIC_44870 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) MAIC_44900 ENOG4105D3W isochorismatase MAIC_44920 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr MAIC_44950 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) MAIC_44990 ENOG4105S7A ErfK ybiS ycfS ynhG family protein MAIC_45090 ENOG4105K5B UPF0225 protein MAIC_45140 ENOG4105D8X mechanosensitive ion channel MAIC_45230 ENOG4105EW6 flavin reductase domain protein, FMN-binding MAIC_45310 ENOG4107QJT sodium dicarboxylate symporter MAIC_45320 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism MAIC_45330 ENOG4108V9W transcriptional regulatory protein MAIC_45340 ENOG4105C26 Dehydrogenase MAIC_45350 ENOG4105C1G acyl-Coa dehydrogenase MAIC_45410 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) MAIC_45440 ENOG4106N8J Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) MAIC_45450 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) MAIC_45480 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) MAIC_45500 ENOG410849U 50S ribosomal protein L30 MAIC_45510 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) MAIC_45520 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) MAIC_45560 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits MAIC_45570 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) MAIC_45580 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) MAIC_45590 ENOG4105E6M Sulphatase-modifying factor protein MAIC_45620 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) MAIC_45630 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal MAIC_45640 ENOG41082SA 50s ribosomal protein l29 MAIC_45660 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) MAIC_45680 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) MAIC_45690 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity MAIC_45710 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) MAIC_45720 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) MAIC_45790 ENOG4105EBR Carboxylesterase MAIC_45820 ENOG4105C57 major facilitator superfamily MAIC_45880 ENOG4105XDV MAIC_45930 ENOG4105F7P transcriptional regulator AsnC family MAIC_45940 ENOG4105CIK Amidinotransferase MAIC_45950 ENOG4105C8Y Acetylornithine aminotransferase MAIC_45960 ENOG4105CUB amino acid MAIC_45980 ENOG4108BAS reductase MAIC_45990 ENOG4105CEU Arginine dihydrolase MAIC_46020 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) MAIC_46030 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) MAIC_46080 ENOG4106YT9 Enoyl-CoA hydratase MAIC_46110 ENOG4105CSU acyl-Coa dehydrogenase MAIC_46140 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) MAIC_46160 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) MAIC_46170 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) MAIC_46210 ENOG41082SK Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) MAIC_46220 ENOG4108VZM 50s ribosomal protein L10 MAIC_46280 ENOG4105FP9 thiamine pyrophosphate MAIC_46390 ENOG4108QV3 biosynthesis protein MAIC_46410 ENOG4105C0K Gdp-mannose 4,6-dehydratase MAIC_46420 ENOG4108DMA Nad-dependent epimerase dehydratase MAIC_46470 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase MAIC_46480 ENOG4107SZR mannose-6-phosphate isomerase MAIC_46500 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) MAIC_46520 ENOG4108TJN glycosyl transferase group 1 MAIC_46540 ENOG4105C6Y Udp-glucose 6-dehydrogenase MAIC_46550 ENOG4105D3Q Sugar transferase MAIC_46590 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) MAIC_46640 ENOG4108F01 MaoC domain protein MAIC_46650 ENOG410900P UPF0336 protein MAIC_46660 ENOG4105WDJ 50S ribosomal protein L33 MAIC_46710 ENOG4105E39 Enoyl-CoA hydratase MAIC_46770 ENOG41073TP transcriptional regulator MAIC_46820 ENOG4108IYU L-aspartate oxidase MAIC_46870 ENOG4107UBC ErfK ybiS ycfS ynhG family protein MAIC_46880 ENOG4107UBC ErfK ybiS ycfS ynhG family protein MAIC_46900 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) MAIC_46940 ENOG4105C1J atp-dependent rna helicase MAIC_46950 ENOG4105VEQ Cold shock protein MAIC_47050 ENOG4105CSH Transporter MAIC_47080 ENOG4107QIZ NADH dehydrogenase MAIC_47130 ENOG4107RCI amp-dependent synthetase and ligase MAIC_47190 ENOG4105CY3 ABC transporter, permease MAIC_47280 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) MAIC_47500 ENOG4106H3A restriction MAIC_47540 ENOG4105C0D helicase MAIC_47570 ENOG4105C4R Atp-dependent dna helicase MAIC_47670 ENOG4105C57 major facilitator superfamily MAIC_47740 ENOG4105BZU Histidine kinase MAIC_47750 ENOG4107R6F Alpha Beta Hydrolase Fold protein MAIC_47810 ENOG4105YIP Tetr family transcriptional regulator MAIC_47840 ENOG4108VPT UPF0234 protein MAIC_47850 ENOG4105CT3 Monooxygenase MAIC_47880 ENOG4105D0M Protease HtpX homolog MAIC_47900 ENOG4105P52 geranylgeranyl reductase MAIC_47930 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) MAIC_47940 ENOG4105E1F short-chain dehydrogenase reductase MAIC_47980 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) MAIC_48060 ENOG41082JN Transcriptional regulator MAIC_48070 ENOG4107TCW O-succinylbenzoate synthase MAIC_48110 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_48160 ENOG4105PDP Short chain dehydrogenase MAIC_48300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MAIC_48340 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) MAIC_48350 ENOG4105D3R alkyl hydroperoxide reductase MAIC_48360 ENOG4108IAJ Nad-dependent epimerase dehydratase MAIC_48370 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) MAIC_48440 ENOG4105CRE cytochrome C MAIC_48460 ENOG4107QIV Cytochrome c biogenesis protein MAIC_48480 ENOG4108RH7 phosphoglycerate mutase MAIC_48550 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) MAIC_48730 ENOG410900P UPF0336 protein MAIC_48800 ENOG41063NU Membrane MAIC_48840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MAIC_48850 ENOG4105BZU Histidine kinase MAIC_48870 ENOG4108YZJ Pfam:DUF2596 MAIC_48880 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) MAIC_48930 ENOG4107R4N Cell wall formation (By similarity) MAIC_48990 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) MAIC_49010 ENOG4105TT9 Protein of unknown function (DUF2516) MAIC_49020 ENOG4105V9F hemagglutinin MAIC_49040 ENOG4106BRA Membrane MAIC_49080 ENOG4105CSR polyphosphate kinase 2 MAIC_49090 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase MAIC_49210 ENOG4105C26 Dehydrogenase MAIC_49220 ENOG4107RR1 TRANSCRIPTIONal MAIC_49230 ENOG4105CHR reductase MAIC_49320 ENOG4105CSR polyphosphate kinase 2 MAIC_49420 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) MAIC_49460 ENOG4105JZI cytochrome P450 MAIC_49470 ENOG4107EMZ glycosyl transferase family MAIC_49530 ENOG4107RCI amp-dependent synthetase and ligase MAIC_49570 ENOG4105CHR reductase MAIC_49670 ENOG4105D65 subunit l MAIC_49680 ENOG4105MKQ Monovalent cation H antiporter subunit C MAIC_49690 ENOG4108JPZ Monovalent cation H antiporter subunit D MAIC_49750 ENOG4108KB2 LysR family Transcriptional regulator MAIC_49830 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) MAIC_49860 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein MAIC_49920 ENOG4105DWF phosphomethylpyrimidine kinase MAIC_49940 ENOG4105F95 Monooxygenase MAIC_49970 ENOG4105C2W permease MAIC_49990 ENOG4105IIU Aminopeptidase MAIC_50000 ENOG4108PJD permease MAIC_50030 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) MAIC_50050 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) MAIC_50090 ENOG4105CT1 (ABC) transporter MAIC_50100 ENOG4107Q25 Serine Threonine protein kinase MAIC_50130 ENOG4105MHT Transcriptional regulator, ARSR family MAIC_50160 ENOG4108SEA Esterase MAIC_50170 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) MAIC_50230 ENOG4105DMT epimerase dehydratase MAIC_50280 ENOG4105K64 Glycosyl transferase, family 2 MAIC_50300 ENOG4107Y2G Glycosyl transferase (Group 1 MAIC_50320 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) MAIC_50370 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MAIC_50380 ENOG4105C5X domain protein MAIC_50400 ENOG4105EMU Dehydrogenase MAIC_50450 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR MAIC_50500 ENOG4105EYF MMPL domain protein MAIC_50540 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis MAIC_50560 ENOG4107XZ0 Peptidase M50 MAIC_50590 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_50600 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) MAIC_50610 ENOG4105C1G acyl-Coa dehydrogenase MAIC_50620 ENOG4105CHR reductase MAIC_50660 ENOG4108RF4 Tetr family transcriptional regulator MAIC_50670 ENOG4108RF4 Tetr family transcriptional regulator MAIC_50700 ENOG4105ME7 Membrane MAIC_50740 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN MAIC_50840 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) MAIC_50930 ENOG4108W6C Dehydrogenase MAIC_50960 ENOG4108IG5 Transcriptional regulator MAIC_50970 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit MAIC_51140 ENOG4108JYK Dehydrogenase MAIC_51150 ENOG4105CPP Dehydrogenase, E1 component MAIC_51170 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) MAIC_51190 ENOG4105KNI merR family transcriptional Regulator MAIC_51200 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) MAIC_51210 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ MAIC_51220 ENOG4105CFG Acts as a chaperone (By similarity) MAIC_51380 ENOG4105DEN Luciferase family MAIC_51480 ENOG4105DF6 Fe-S oxidoreductase MAIC_51580 ENOG4105C6Y Udp-glucose 6-dehydrogenase MAIC_51670 ENOG4106MP8 UPF0754 membrane protein MAIC_51790 ENOG4105DEF Extracellular solute-binding protein, family 5 MAIC_51800 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MAIC_51830 ENOG4108JQ7 (ABC) transporter MAIC_51850 ENOG4105C7K acetolactate synthase MAIC_51880 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase MAIC_51930 ENOG4105CS1 NAD(P)H quinone oxidoreductase MAIC_52010 ENOG4105YVM Phosphoesterase, PA-phosphatase related MAIC_52050 ENOG4105EDW glycosyl transferase, family 39 MAIC_52130 ENOG4108JQ1 Dehydrogenase MAIC_52150 ENOG4105D2B acyl-CoA dehydrogenase MAIC_52170 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_52210 ENOG4106VYT conserved transmembrane protein MAIC_52220 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin MAIC_52230 ENOG4106K94 growth MAIC_52350 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_52360 ENOG4105C0W non-ribosomal peptide synthetase MAIC_52370 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase MAIC_52450 ENOG4105C26 Dehydrogenase MAIC_52460 ENOG4105C1G acyl-Coa dehydrogenase MAIC_52470 ENOG4105C26 Dehydrogenase MAIC_52500 ENOG4105CPQ Dehydrogenase MAIC_52510 ENOG4105CTS PTS system mannitol-specific MAIC_52520 ENOG4107FB0 transcriptional regulator DeoR family MAIC_52550 ENOG4105WH1 Two component transcriptional regulator luxr family MAIC_52570 ENOG4108R85 Short chain dehydrogenase MAIC_52580 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) MAIC_52600 ENOG4105F57 Anthranilate dioxygenase reductase MAIC_52630 ENOG4105CC9 acyl-Coa dehydrogenase MAIC_52640 ENOG4105D2B acyl-CoA dehydrogenase MAIC_52650 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_52660 ENOG4105DUX Transporter MAIC_52680 ENOG4107UBC ErfK ybiS ycfS ynhG family protein MAIC_52780 ENOG4105P4J Allophanate hydrolase, subunit 1 MAIC_52790 ENOG4107R7A Allophanate hydrolase subunit 2 MAIC_52810 ENOG4108V8F Transcriptional regulator, MarR family MAIC_52840 ENOG4105CR4 methylisocitrate lyase MAIC_52870 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) MAIC_52900 ENOG4105MXW flavin reductase domain protein, FMN-binding MAIC_52970 ENOG4105CSU acyl-Coa dehydrogenase MAIC_52990 ENOG4105CHU acetyl-coa acetyltransferase MAIC_53000 ENOG4105CHR reductase MAIC_53060 ENOG41073B4 coagulation factor 5 8 type domain-containing protein MAIC_53080 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_53090 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) MAIC_53160 ENOG41090MF Protein of unknown function (DUF3068) MAIC_53200 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit MAIC_53230 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) MAIC_53240 ENOG4108M6P methyltransferase MAIC_53270 ENOG4105CSU acyl-Coa dehydrogenase MAIC_53320 ENOG4105D2B acyl-CoA dehydrogenase MAIC_53330 ENOG4105C1G acyl-Coa dehydrogenase MAIC_53340 ENOG4105E39 Enoyl-CoA hydratase MAIC_53360 ENOG4105CEY Amp-dependent synthetase and ligase MAIC_53410 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) MAIC_53430 ENOG4105E2A Dehydrogenase MAIC_53460 ENOG4105D2B acyl-CoA dehydrogenase MAIC_53470 ENOG4105CC9 acyl-Coa dehydrogenase MAIC_53500 ENOG4105DRR Transcriptional regulator, GntR family MAIC_53510 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) MAIC_53520 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) MAIC_53550 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component MAIC_53620 ENOG4105C1G acyl-Coa dehydrogenase MAIC_53640 ENOG4105E39 Enoyl-CoA hydratase MAIC_53670 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) MAIC_53700 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) MAIC_53720 ENOG4107R13 MMPL domain protein MAIC_53770 ENOG4108TAG Histidine kinase MAIC_53810 ENOG4107WA4 MmpL domain-containing protein MAIC_53830 ENOG4105K4P CoA-binding domain protein MAIC_53860 ENOG4105C9K Endothelin-converting enzyme 1 MAIC_53870 ENOG4108A65 Transcriptional regulator MAIC_53880 ENOG4105C2C drug resistance transporter, Bcr CflA MAIC_53900 ENOG4105S7A ErfK ybiS ycfS ynhG family protein MAIC_53920 ENOG4105VPX protein, conserved in bacteria MAIC_53940 ENOG4105C01 Dihydroxy-acid dehydratase MAIC_53980 ENOG4108FUF Transcriptional regulator, IclR family MAIC_53990 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) MAIC_54100 ENOG4105E5G Alpha beta hydrolase fold MAIC_54120 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) MAIC_54160 ENOG41066UM arsR family transcriptional regulator MAIC_54210 ENOG4105E1F short-chain dehydrogenase reductase MAIC_54220 ENOG4105XPP Protein of unknown function (DUF1275) MAIC_54340 ENOG4105CY3 ABC transporter, permease MAIC_54380 ENOG4108R86 Transcriptional regulator MAIC_54440 ENOG4105VBF alkaline shock protein MAIC_54550 ENOG4105C1G acyl-Coa dehydrogenase MAIC_54590 ENOG4105EIG urea carboxylase-associated protein 1 MAIC_54600 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) MAIC_54610 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) MAIC_54640 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr MAIC_54650 ENOG4108UGJ Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) MAIC_54670 ENOG4105C26 Dehydrogenase MAIC_54700 ENOG4105EUB pirin domain protein MAIC_54710 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) MAIC_54720 ENOG410804X Transcriptional regulator MAIC_54730 ENOG4105DE4 1-phosphofructokinase MAIC_54740 ENOG4105DM4 PTS System MAIC_54750 ENOG4105KRI phosphocarrier protein (HPr MAIC_54760 ENOG4105C5X domain protein MAIC_54800 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) MAIC_54810 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction MAIC_54900 ENOG4107R50 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) MAIC_54980 ENOG410905P Pyridoxamine 5-phosphate MAIC_55000 ENOG4106N8J Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) MAIC_55040 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) MAIC_55050 ENOG4107R16 Multicopper oxidase MAIC_55060 ENOG4105BZU Histidine kinase MAIC_55090 ENOG4105EDW glycosyl transferase, family 39 MAIC_55120 ENOG4105EJ2 Transcriptional regulator MAIC_55130 ENOG4107XGZ Hydrolase MAIC_55210 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) MAIC_55230 ENOG4105C1G acyl-Coa dehydrogenase MAIC_55280 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F MAIC_55330 ENOG4105CJ1 ABC, transporter MAIC_55370 ENOG4105C7H Helicase, RecD TraA family MAIC_55380 ENOG4107QKA exodeoxyribonuclease V beta MAIC_55390 ENOG4105DSY exodeoxyribonuclease V, gamma MAIC_55400 ENOG4106R7G Glycoside hydrolase family 5 MAIC_55410 ENOG4105CBG Sulfatase MAIC_55420 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) MAIC_55430 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein MAIC_55450 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MAIC_55520 ENOG4107QVM von Willebrand factor, type A MAIC_55630 ENOG4105XPP Protein of unknown function (DUF1275) MAIC_55650 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MAIC_55710 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) MAIC_55720 ENOG4108IPT Naphthoate synthase MAIC_55800 ENOG4105CPQ Dehydrogenase MAIC_55820 ENOG4105YIP Tetr family transcriptional regulator MAIC_55840 ENOG4105DFH Transport of potassium into the cell (By similarity) MAIC_55850 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) MAIC_55860 ENOG4107QR9 Iron-sulfur cluster binding protein MAIC_55870 ENOG41080R8 Conserved Protein MAIC_55910 ENOG4108YRB methyltransferase MAIC_55940 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands MAIC_56060 ENOG4105M5P UPF0310 protein MAIC_56070 ENOG4105EUB pirin domain protein MAIC_56100 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) MAIC_56130 ENOG4105CUB amino acid MAIC_56140 ENOG4105EFZ amidohydrolase MAIC_56190 ENOG410620I Diguanylate cyclase MAIC_56200 ENOG4105BZU Histidine kinase MAIC_56230 ENOG4105TV9 FHA Domain-Containing protein MAIC_56240 ENOG4105HZM Fha domain containing protein MAIC_56270 ENOG4105CJN penicillin-binding protein MAIC_56280 ENOG4107TPY serine threonine protein kinase MAIC_56290 ENOG4105D9P serine threonine protein kinase MAIC_56380 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MAIC_56390 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MAIC_56400 ENOG4105K7N UPF0232 protein MAIC_56410 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) MAIC_56420 ENOG4108J5G 6-phosphogluconate dehydrogenase MAIC_56430 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) MAIC_56460 ENOG4108CDF RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) MAIC_56470 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins MAIC_56490 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) MAIC_56500 ENOG4107QJE Chromosome Partitioning Protein MAIC_56530 ENOG4108E1C hydrolase MAIC_56630 ENOG4105BZU Histidine kinase MAIC_56670 ENOG41081DT UPF0301 protein MAIC_56680 ENOG4105DHU Bile acid MAIC_56700 ENOG41064CH Probable lipoprotein LpqN MAIC_56710 ENOG4105C8T Leucyl-tRNA synthetase MAIC_56720 ENOG4108IXY short-chain dehydrogenase reductase MAIC_56750 ENOG4105CDA abc transporter atp-binding protein MAIC_56760 ENOG4105DRP amino acid AbC transporter MAIC_56790 ENOG4105DYW oxidoreductase MAIC_56810 ENOG4105CZA synthase MAIC_56850 ENOG4105BZ4 penicillin-binding protein MAIC_56880 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) MAIC_56910 ENOG4105K9Q Binds to the 23S rRNA (By similarity) MAIC_56960 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) MAIC_57060 ENOG4108IG5 Transcriptional regulator MAIC_57070 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) MAIC_57100 ENOG4108JT6 LycopEne MAIC_57200 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) MAIC_57210 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) MAIC_57220 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)